SKF38393 HCl

For research use only.

Catalog No.S7993

SKF38393 HCl Chemical Structure

CAS No. 62717-42-4

SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.

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Biological Activity

Description SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
dopamine D1 receptor [1] D5 receptor [1]
In vitro

SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4]

In vivo SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5]


Animal Research:[3]
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  • Animal Models: Male Wistar rats
  • Dosages: 6 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 58 mg/mL (198.78 mM)
Ethanol 6 mg/mL warmed (20.56 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 291.77

C16H17NO2 . HCl

CAS No. 62717-42-4
Storage powder
in solvent
Synonyms N/A
Smiles C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Dopamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID