SKF38393 HCl

Catalog No.S7993

For research use only.

SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.

SKF38393 HCl Chemical Structure

CAS No. 62717-42-4

Purity & Quality Control

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Biological Activity

Description SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
dopamine D1 receptor [1] D5 receptor [1]
In vitro

SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4]

In vivo SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5]

Protocol (from reference)

Animal Research:[3]
  • Animal Models: Male Wistar rats
  • Dosages: 6 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 291.77

C16H17NO2 . HCl

CAS No. 62717-42-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl

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