SKF38393 HCl

Catalog No.S7993

For research use only.

SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.

SKF38393 HCl Chemical Structure

CAS No. 62717-42-4

Purity & Quality Control

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Biological Activity

Description SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
Targets
dopamine D1 receptor [1] D5 receptor [1]
In vitro

SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4]

In vivo SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5]

Protocol (from reference)

Animal Research:[3]
  • Animal Models: Male Wistar rats
  • Dosages: 6 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 291.77
Formula

C16H17NO2 . HCl

CAS No. 62717-42-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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