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Solifenacin succinate

Name: Solifenacin succinate
Brand: Selleck Chemicals
SKU: S3048
Rating: 5 (1 reviews)

Synonyms: YM905

Catalog No.S3048 Purity: 99.97%

Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.

Solifenacin succinate Chemical Structure

CAS: 242478-38-2

Purity & Quality Control

Batch: S304801 Water] 96 mg/mL] false] Ethanol] 5 mg/mL] false] DMSO] 3 mg/mL] false Purity: 99.97%

99.97

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Signaling Pathway

AChR Signaling Pathway

Choose Selective AChR Inhibitors

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
CHO-K1 cells	Function assay		1 h		Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting, IC50=0.0635 μM	21524581
Click to View More Cell Line Experimental Data

Biological Activity

Description

Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.

Targets

mAChR ^[1]

In vitro
In vitro	Solifenacin succinate is a new muscarinic receptor antagonist developed for the treatment of overactive bladder. The affinity constants (pKi) of solifenacin for recombinant human muscarinic M1, M2 and M3 receptors are 7.6, 6.9 and 8.0, respectively. Hence, the muscarinic M3 receptor subtype selectivity of solifenacin over the muscarinic M2 receptor subtype is readily apparent, but is only marginal over the muscarinic M1 receptor subtype. In the same study, solifenacin and oxybutynin inhibit muscarinic M3 receptor-mediated intracellular Ca2+ mobilization in bladder smooth muscle cells isolated from guinea pigs and in submandibular gland cells isolated from mice.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05391425	Recruiting	Urge Incontinence\|Urgency-frequency Syndrome	Istanbul University\|Arnavutkoy State Hospital	June 3 2021	--
NCT05040984	Recruiting	Overactive Bladder Syndrome	Far Eastern Memorial Hospital	April 30 2021	--
NCT04693897	Unknown status	Overactive Bladder Syndrome\|Detrusor Overactivity	Chang Gung Memorial Hospital	March 1 2021	--
NCT02940314	Completed	Overactive Bladder	Hanmi Pharmaceutical Company Limited	March 2016	Phase 1

References

Chemical Information & Solubility

Molecular Weight	480.55	Formula	C₂₃H₂₆N₂O.C₄H₆O₄
CAS No.	242478-38-2	SDF	Download Solifenacin succinate SDF
Smiles	C1CN2CCC1C(C2)OC(=O)N3CCC4=CC=CC=C4C3C5=CC=CC=C5.C(CC(=O)O)C(=O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 96 mg/mL

Ethanol : 5 mg/mL

DMSO : 3 mg/mL ( (6.24 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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