Solifenacin succinate

For research use only.

Catalog No.S3048 Synonyms: YM905

Solifenacin succinate Chemical Structure

CAS No. 242478-38-2

Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.

Purity & Quality Control

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Biological Activity

Description Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.
Targets
mAChR [1]
In vitro

Solifenacin succinate is a new muscarinic receptor antagonist developed for the treatment of overactive bladder. The affinity constants (pKi) of solifenacin for recombinant human muscarinic M1, M2 and M3 receptors are 7.6, 6.9 and 8.0, respectively. Hence, the muscarinic M3 receptor subtype selectivity of solifenacin over the muscarinic M2 receptor subtype is readily apparent, but is only marginal over the muscarinic M1 receptor subtype. In the same study, solifenacin and oxybutynin inhibit muscarinic M3 receptor-mediated intracellular Ca2+ mobilization in bladder smooth muscle cells isolated from guinea pigs and in submandibular gland cells isolated from mice.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO-K1 cells Mo[5SpVv[3Srb36gZZN{[Xl? NG\NUmgyKGh? MV7EbZNxdGGlZX3lcpQhd2ZiW{PIYW5OWyCocn;tJIh2dWGwIH31d4NiemmwaXOgUVEhemWlZYD0c5Ih\XiycnXzd4VlKGmwIFPIU{1MOSClZXzsd{Bi\nSncjCxJIhzKGK7IIPjbY51cWyuYYTpc44h[2:3boTpcoctKEmFNUC9NE4xPjN3IN88US=> MVWyNVUzPDV6MR?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro Water 96 mg/mL (199.77 mM)
Ethanol 5 mg/mL (10.4 mM)
DMSO 3 mg/mL (6.24 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 480.55
Formula

C23H26N2O.C4H6O4

CAS No. 242478-38-2
Storage powder
in solvent
Synonyms YM905
Smiles C1CN2CCC1C(C2)OC(=O)N3CCC4=CC=CC=C4C3C5=CC=CC=C5.C(CC(=O)O)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04693897 Not yet recruiting Drug: Mirabegron 50 MG|Drug: Solifenacin Succinate 5 MG Overactive Bladder Syndrome|Detrusor Overactivity Chang Gung Memorial Hospital March 1 2021 --
NCT02940314 Completed Drug: HIP1503|Drug: HGP1103 Overactive Bladder Hanmi Pharmaceutical Company Limited March 2016 Phase 1
NCT02127034 Completed Drug: Mirabegron|Drug: Solifenacin|Drug: Digoxin Healthy Subjects|Pharmacokinetics|Drug-Drug Interaction (DDI) Astellas Pharma Europe B.V.|Astellas Pharma Inc March 2014 Phase 1
NCT01880619 Completed Drug: Tamsulosin|Drug: Solifenacin|Drug: Control Relieve of Ureteral Stent Symptoms Mansoura University January 2013 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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AChR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID