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SIS3

Name: SIS3
Brand: Selleck Chemicals
SKU: S3552
Rating: 5 (7 reviews)

Catalog No.S3552

For research use only.

SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.

CAS No. 1009104-85-1

Selleck's SIS3 has been cited by 7 Publications

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Biological Activity

Description	SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.

Protocol (from reference)

References

[1] Jinnin M, et al. Mol Pharmacol. 2006 Feb;69(2):597-607.

Solubility (25°C)

In vitro	DMSO	91 mg/mL (200.64 mM)
	Ethanol	91 mg/mL (200.64 mM)
	Water	Insoluble

Chemical Information

Molecular Weight	453.53
Formula	C₂₈H₂₇N₃O₃
CAS No.	1009104-85-1
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number	Recruitment	Interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03884621	Completed	Other: EHP Group	Stroke	The Hong Kong Polytechnic University	September 25 2018	Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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