SIS3

For research use only.

Catalog No.S3552

2 publications

CAS No. 1009104-85-1

SIS3 is a cell-permeable inhibitor of SMAD3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.

Selleck's SIS3 has been cited by 2 publications

Purity & Quality Control

Biological Activity

Description SIS3 is a cell-permeable inhibitor of SMAD3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.

Protocol

References

Solubility (25°C)

Chemical Information

Molecular Weight
Formula
CAS No. 1009104-85-1
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03884621 Completed Other: EHP Group Stroke The Hong Kong Polytechnic University September 25 2018 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID