SIS3

Name: SIS3
Brand: Selleck Chemicals
SKU: S3552
Rating: 5 (2 reviews)

For research use only.

Catalog No.S3552

2 publications

CAS No. 1009104-85-1

SIS3 is a cell-permeable inhibitor of SMAD3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.

Selleck's SIS3 has been cited by 2 publications

Front Cell Dev Biol, 2021, 9:632372

PubMed: 33816481 ( click the link to review the publication )

Mol Biol Cell, 2018, 29(7):797-808

PubMed: 29467255 ( click the link to review the publication )

Purity & Quality Control

Biological Activity

Description	SIS3 is a cell-permeable inhibitor of SMAD3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.

Protocol

References

Solubility (25°C)

Chemical Information

Molecular Weight
Formula
CAS No.	1009104-85-1
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A

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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03884621	Completed	Other: EHP Group	Stroke	The Hong Kong Polytechnic University	September 25 2018	Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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