Home Microbiology Parasite inhibitor SQ109 For research use only.

SQ109

SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC50 for LLC-MK2 culture-derived trypomastigotes of 50±8 nM, targets MmpL3 (mycobacterial membrane protein large 3) in Mycobacterium tuberculosis.

SQ109 Chemical Structure

SQ109 Chemical Structure

CAS: 502487-67-4

Purity & Quality Control

Batch: S126501 Purity: 99.16%
99.16

SQ109 Related Products

Choose Selective Parasite Inhibitors

Biological Activity

Description SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC50 for LLC-MK2 culture-derived trypomastigotes of 50±8 nM, targets MmpL3 (mycobacterial membrane protein large 3) in Mycobacterium tuberculosis.
Targets
MmpL3 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01252108 Withdrawn
Helicobacter Pylori Infection
Sequella Inc.
 March 2012 Phase 2
NCT01358162 Completed
Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 November 2010 Phase 1
NCT01218217 Completed
Tuberculosis Pulmonary
Michael Hoelscher|Sequella Inc.|European and Developing Countries Clinical Trials Partnership (EDCTP)|German Federal Ministry of Education and Research|Quintiles Inc.|CMed Technologies Inc.|PathCare|Parexel|Ludwig-Maximilians - University of Munich
 November 2010 Phase 2
NCT00866190 Completed
TB Multi-drug Resistant
National Institute of Allergy and Infectious Diseases (NIAID)
 April 2009 Phase 1
NCT01585636 Completed
Tuberculosis
Sequella Inc.|Quintiles Inc.
 September 2006 Phase 1
NCT01874314 Withdrawn
Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 Phase 1

Chemical Information & Solubility

Molecular Weight 330.55 Formula

C22H38N2
CAS No. 502487-67-4 SDF --
Smiles CC(C)=CCC/C(C)=C/CNCCNC1C2CC3CC(C2)CC1C3
Storage (From the date of receipt) 2 years -80 liquid

In vitro
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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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