Catalog No.S4175

For research use only.

Sulfaguanidine is a sulfonamide used as an anti-infective agent.

Sulfaguanidine Chemical Structure

CAS No. 57-67-0

Purity & Quality Control

Choose Selective Anti-infection Inhibitors

Biological Activity

Description Sulfaguanidine is a sulfonamide used as an anti-infective agent.
In vitro

Sulfaguanidine is the first sulfonamide designed to treat enteric infections. Sulfaguanidine have been found to be particularly effective in preventing the growth of the gram-negative intestinal bacilli. It is a useful tool for the inhibition of synthesis of nutritional factors by intestinal bacteria. [1]

In vivo In adult rats, sulfaguanidine's elimination from plasma, after intravenous administration of 2.5 or 25 mg/kg doses, while its plasma concentration after oral administration of 25 mg/kg doses. Neonatal rats displayed a lower elimination of sulfaguanidine than adult rats. Comparison of the drug's gastrointestinal absorption shows that the maximum plasma concentration after oral administration is significantly higher for neonatal than for adult rats. However, there is no significant difference between the times required to reach maximum plasma concentrations. The absolute bioavailability (57.86%) in neonatal rats is approximately five times that (12.76%) in adult rats. Thus, sulfaguanidine is poorly absorbed by adult rats, but is efficiently absorbed by immature gastrointestines of neonatal rats. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 43 mg/mL
(200.7 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 214.24

C7 H10N4O2S

CAS No. 57-67-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=CC=C1N)S(=O)(=O)N=C(N)N

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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