Home Microbiology Anti-infection chemical Sulfaguanidine

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Sulfaguanidine Anti-infection chemical

Sulfaguanidine is a sulfonamide used as an anti-infective agent. This compound is commonly employed in the treatment of gastrointestinal infections due to its efficacy against certain bacterial strains. It works by inhibiting the growth and reproduction of bacteria, thereby helping to control the spread of infection. The use of this chemical has been well-documented in veterinary medicine as well.

Sulfaguanidine Anti-infection chemical Chemical Structure

Chemical Structure

Molecular Weight: 214.24

Purity & Quality Control

Batch: S417501 DMSO]43 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.01%
99.01

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Mechanism of Action

In vitro
In vitro Sulfaguanidine is the first sulfonamide designed to treat enteric infections. This compound has been found to be particularly effective in preventing the growth of the gram-negative intestinal bacilli. It is a useful tool for the inhibition of synthesis of nutritional factors by intestinal bacteria. [1]

In Vivo
In vivo In adult rats, sulfaguanidine's elimination from plasma, after intravenous administration of 2.5 or 25 mg/kg doses, while its plasma concentration after oral administration of 25 mg/kg doses. Neonatal rats displayed a lower elimination of this compound than adult rats. Comparison of the drug's gastrointestinal absorption shows that the maximum plasma concentration after oral administration is significantly higher for neonatal than for adult rats. However, there is no significant difference between the times required to reach maximum plasma concentrations. The absolute bioavailability (57.86%) in neonatal rats is approximately five times that (12.76%) in adult rats. Thus, this chemical is poorly absorbed by adult rats, but is efficiently absorbed by immature gastrointestines of neonatal rats. [1]

References
  • https://pubmed.ncbi.nlm.nih.gov/3820055/

Chemical Information

Molecular Weight 214.24 Formula

C7 H10N4O2S
CAS No. 57-67-0 SDF Download SDF
Synonyms N/A
Smiles C1=CC(=CC=C1N)S(=O)(=O)N=C(N)N

Storage and Stability

Storage (From the date of receipt)

In vitro
Batch:

DMSO : 43 mg/mL ( (200.7 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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