Home Microbiology Anti-infection chemical Sulfaguanidine

research use only

Sulfaguanidine Anti-infection chemical

Cat.No.S4175

Sulfaguanidine is a sulfonamide used as an anti-infective agent. This compound is commonly employed in the treatment of gastrointestinal infections due to its efficacy against certain bacterial strains. It works by inhibiting the growth and reproduction of bacteria, thereby helping to control the spread of infection. The use of this chemical has been well-documented in veterinary medicine as well.
Sulfaguanidine Anti-infection chemical Chemical Structure

Chemical Structure

Molecular Weight: 214.24

Jump to

Quality Control

Batch: S417501 DMSO]43 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.01%
  • Cited in Nature Medicine for its top-tier quality
  • COA
  • NMR
  • HPLC
  • SDS
  • Datasheet
99.01

Solubility

In vitro
Batch:

DMSO : 43 mg/mL (200.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 214.24 Formula

C7 H10N4O2S

 Storage (From the date of receipt)
CAS No. 57-67-0 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C1=CC(=CC=C1N)S(=O)(=O)N=C(N)N

Mechanism of Action

In vitro
Sulfaguanidine is the first sulfonamide designed to treat enteric infections. This compound has been found to be particularly effective in preventing the growth of the gram-negative intestinal bacilli. It is a useful tool for the inhibition of synthesis of nutritional factors by intestinal bacteria.
In vivo
In adult rats, sulfaguanidine's elimination from plasma, after intravenous administration of 2.5 or 25 mg/kg doses, while its plasma concentration after oral administration of 25 mg/kg doses. Neonatal rats displayed a lower elimination of this compound than adult rats. Comparison of the drug's gastrointestinal absorption shows that the maximum plasma concentration after oral administration is significantly higher for neonatal than for adult rats. However, there is no significant difference between the times required to reach maximum plasma concentrations. The absolute bioavailability (57.86%) in neonatal rats is approximately five times that (12.76%) in adult rats. Thus, this chemical is poorly absorbed by adult rats, but is efficiently absorbed by immature gastrointestines of neonatal rats.
References

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.