For research use only.

Catalog No.S4175

Sulfaguanidine Chemical Structure

CAS No. 57-67-0

Sulfaguanidine is a sulfonamide used as an anti-infective agent.

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Biological Activity

Description Sulfaguanidine is a sulfonamide used as an anti-infective agent.
In vitro

Sulfaguanidine is the first sulfonamide designed to treat enteric infections. Sulfaguanidine have been found to be particularly effective in preventing the growth of the gram-negative intestinal bacilli. It is a useful tool for the inhibition of synthesis of nutritional factors by intestinal bacteria. [1]

In vivo In adult rats, sulfaguanidine's elimination from plasma, after intravenous administration of 2.5 or 25 mg/kg doses, while its plasma concentration after oral administration of 25 mg/kg doses. Neonatal rats displayed a lower elimination of sulfaguanidine than adult rats. Comparison of the drug's gastrointestinal absorption shows that the maximum plasma concentration after oral administration is significantly higher for neonatal than for adult rats. However, there is no significant difference between the times required to reach maximum plasma concentrations. The absolute bioavailability (57.86%) in neonatal rats is approximately five times that (12.76%) in adult rats. Thus, sulfaguanidine is poorly absorbed by adult rats, but is efficiently absorbed by immature gastrointestines of neonatal rats. [1]


Solubility (25°C)

In vitro DMSO 43 mg/mL (200.7 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 214.24

C7 H10N4O2S

CAS No. 57-67-0
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC(=CC=C1N)S(=O)(=O)N=C(N)N

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID