Catalog No.S1915

For research use only.

Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM.

Sulfamethoxazole Chemical Structure

CAS No. 723-46-6

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 51 mg/mL
(201.35 mM)
Water Insoluble
Ethanol '23 mg/mL

Chemical Information

Molecular Weight 253.28


CAS No. 723-46-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02475876 Completed Drug: Clindamycin|Drug: trimethoprim-sulfamethoxazole Bacterial Infections Michael Cohen-Wolkowiez|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Duke University November 2015 Phase 1
NCT01167452 Completed Drug: Sulfamethoxazole/trimethoprim Obesity|Pharmacokinetics|MRSA|Tuberculosis|PCP Texas Tech University Health Sciences Center|National Center for Research Resources (NCRR)|University of Texas Southwestern Medical Center July 2010 Phase 4
NCT01272999 Completed Other: No intervention Acute Otitis Media|Mastoiditis Pfizer May 21 2010 --

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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