Salubrinal

Catalog No.S2923

Salubrinal Chemical Structure

Molecular Weight(MW): 479.81

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

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In DMSO USD 280 In stock
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Cited by 7 Publications

3 Customer Reviews

  • AngII (30 minutes)-induced Akt activation was attenuated by the ER stress inhibitors 4-PBA (5 mM, 2 hours), TUDCA (300 µg/ml, 1 hour), and salubrinal (30 µM, 1 hour) (n=5; *P<0.01 versus con, #P<0.05 versus Ang)

    J Am Soc Nephrol, 2015, 26(8):1839-54. . Salubrinal purchased from Selleck.

    PC-3 and HCT-116 p53+/+ cells were treated with 3-AWA and/or salubrinal for the indicated time point. The protein-specific antibodies were used to analyze the expression of the given proteins through immunoblotting.

    Oncogenesis, 2017, 6(5):e341. Salubrinal purchased from Selleck.

  • HEK293 cells were transfected with or without Flag-VP1 for 24 h, then treated with d Salubrinal (Sal, 75 μM) for 8 h followed by immunoblot detection. All data in this figure represent the mean ± SEM of three independent experiments. *p<0.05; ***p<0.01.

    Neurotox Res, 2017, 31(2):204-217. Salubrinal purchased from Selleck.

Purity & Quality Control

Choose Selective PERK Inhibitors

Biological Activity

Description Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Targets
eIF2α [1]
(Cell-free assay)
In vitro

Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ∼ 15 μM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. However, Salubrinal is not a general apoptosis inhibitor. Salubrinal induced rapid and robust eIF2α phosphorylation and its downstream effects in PC12 cells, including down-regulation of cyclin D1 and up-regulation of GADD34 and CHOP, two proteins whose expression is induced by eIF2α phosphorylation. Salubrinal inhibits eIF2α dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ~ 3μM by inhibiting eIF2α dephosphorylation. [1] Salubrinal increased non-rapid eye movement (NREM) sleep. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human LP-1 cell NV\hOFJIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MofGTY5pcWKrdHnvckBw\iCqdX3hckBNWC1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zO|EyOiEQvF2= NI\Zd3lUSU6JRWK=
human 697 cell NXr3TZhxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXvJcohq[mm2aX;uJI9nKGi3bXHuJFY6PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwOUi3PFgh|ryP NGfUN5lUSU6JRWK=
human ALL-PO cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mm\ITY5pcWKrdHnvckBw\iCqdX3hckBCVExvUF:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlA5PjV3IN88US=> NXe5Nm9IW0GQR1XS
human ML-2 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmTrTY5pcWKrdHnvckBw\iCqdX3hckBOVC1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND62NVg{OyEQvF2= NYPKcXNtW0GQR1XS
human LB2241-RCC cell M{HQdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWTJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjJ2MT3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Njl6NUeyJO69VQ>? M3jNcHNCVkeHUh?=
human Becker cell M{XGdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYPMV2c6UW6qaXLpeIlwdiCxZjDoeY1idiCEZXPr[ZIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njd7NECxJO69VQ>? M2W3SXNCVkeHUh?=
human NEC8 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXnLcnRzUW6qaXLpeIlwdiCxZjDoeY1idiCQRVO4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok4xPTN|MTFOwG0> M1vIe3NCVkeHUh?=
human Daudi cell M3vJXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoXDTY5pcWKrdHnvckBw\iCqdX3hckBF[XWmaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uN|M3QTlizszN MXTTRW5ITVJ?
human MHH-PREB-1 cell NH22b4tIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVHJcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2SUlXCMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03Njd6OEG3JO69VQ>? MUnTRW5ITVJ?
human NCI-H510A cell NYO4UIhPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWLJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUGwRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvODN3M{Wg{txO M2K0eXNCVkeHUh?=
human NCI-H720 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{KwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{42PzJ4ODFOwG0> NHHU[pJUSU6JRWK=
human MRK-nu-1 cell Mn3YS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnXCTY5pcWKrdHnvckBw\iCqdX3hckBOWktvboWtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPzVzN{Gg{txO Mo\LV2FPT0WU
human LB2518-MEL cell MknES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV\q[oJ7UW6qaXLpeIlwdiCxZjDoeY1idiCOQkK1NVguVUWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz65O|MzPiEQvF2= NF\tN|hUSU6JRWK=
human BE-13 cell M3mwWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4nDRmlvcGmkaYTpc44hd2ZiaIXtZY4hSkVvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlI3QDRizszN NV3VNYduW0GQR1XS
human A3-KAW cell NEL4fZBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnXTTY5pcWKrdHnvckBw\iCqdX3hckBCOy2NQWegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlQ{Ojh7IN88US=> NXXnSXZ2W0GQR1XS
human ST486 cell MkXMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXrJcohq[mm2aX;uJI9nKGi3bXHuJHNVPDh4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD61N|Y5KM7:TR?= NVnNb|hlW0GQR1XS
human ES8 cell MlLwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEHWOJFKdmirYnn0bY9vKG:oIHj1cYFvKEWVODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuOlQ{OzlizszN NWXyTIltW0GQR1XS
human HT cell Ml\KS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEKxZ|JKdmirYnn0bY9vKG:oIHj1cYFvKEiWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD65OFE5PSEQvF2= M3fFb3NCVkeHUh?=
human HAL-01 cell M{HZVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4DF[GlvcGmkaYTpc44hd2ZiaIXtZY4hUEGOLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4{OTVyNTFOwG0> NX31eGVmW0GQR1XS
human EB-3 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWCxTmFHUW6qaXLpeIlwdiCxZjDoeY1idiCHQj2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU43OjV5MjFOwG0> MV\TRW5ITVJ?
human EW-1 cell M3zH[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX\EZmh7UW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU44OTJ2IN88US=> MmLyV2FPT0WU
human BL-41 cell MlPBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGHzc|FKdmirYnn0bY9vKG:oIHj1cYFvKEKOLUSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU44QDB2OTFOwG0> MVLTRW5ITVJ?
Ramos-2G6-4C10 cell NEXxRo5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3H6[mlvcGmkaYTpc44hd2ZiaIXtZY4hWmGvb4OtNmc3NTSFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlkxOzF3IN88US=> MVzTRW5ITVJ?
human DOHH-2 cell MkXmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX3lTIFZUW6qaXLpeIlwdiCxZjDoeY1idiCGT1jIMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC5{Mk[yJO69VQ>? MVLTRW5ITVJ?
MONO-MAC-6 cell M4nh[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2DM[mlvcGmkaYTpc44hd2ZiaIXtZY4hVU:QTz3NRWMuPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFyLkW0PFMh|ryP MlHkV2FPT0WU
human NKM-1 cell NUjMfWhLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVjGbYdNUW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjZzOU[g{txO NELmUpVUSU6JRWK=
human HEL cell Mm\QS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGhGVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFyLk[yOVIh|ryP Ml\qV2FPT0WU
human 8-MG-BA cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXHJcohq[mm2aX;uJI9nKGi3bXHuJFguVUdvQlGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE46QTl7IN88US=> NUPtPVNZW0GQR1XS
human K-562 cell NIWxSpRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{\neWlvcGmkaYTpc44hd2ZiaIXtZY4hUy13NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU4xOTlzIN88US=> MWDTRW5ITVJ?
human LXF-289 cell M4HkOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF3Vc5ZKdmirYnn0bY9vKG:oIHj1cYFvKEy[Rj2yPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS5zNUS3JO69VQ>? NEXNVm9USU6JRWK=
human HC-1 cell MnXXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUXmeINJUW6qaXLpeIlwdiCxZjDoeY1idiCKQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOTV2NzFOwG0> MUPTRW5ITVJ?
human MC116 cell MkHaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVPJcohq[mm2aX;uJI9nKGi3bXHuJG1EOTF4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuNlA4OyEQvF2= MWPTRW5ITVJ?
human TE-12 cell M2S5UGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUfJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuN|M2PyEQvF2= MWPTRW5ITVJ?
human BV-173 cell NWPhW5pUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXzIUFZuUW6qaXLpeIlwdiCxZjDoeY1idiCEVj2xO|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS53MEKxJO69VQ>? MUPTRW5ITVJ?
human NCCIT cell NXS4Omx{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHO1U29KdmirYnn0bY9vKG:oIHj1cYFvKE6FQ1nUJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPjB|OTFOwG0> MVnTRW5ITVJ?
human CESS cell NHu5SmJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFr3cVNKdmirYnn0bY9vKG:oIHj1cYFvKEOHU2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU43PjZ{IN88US=> MY\TRW5ITVJ?
human HUTU-80 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH;McVhKdmirYnn0bY9vKG:oIHj1cYFvKEiXVGWtPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS54N{C0JO69VQ>? MVTTRW5ITVJ?
human IST-SL2 cell M2OwbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWLmXYY3UW6qaXLpeIlwdiCxZjDoeY1idiCLU2StV2wzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwN{ewOEDPxE1? MkH2V2FPT0WU
human ATN-1 cell MknlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXHEWXQzUW6qaXLpeIlwdiCxZjDoeY1idiCDVF6tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjB{Mk[g{txO NHn5bJhUSU6JRWK=
human HCC1599 cell NE\ORmJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{HPdGlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUW5PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjFyOUSg{txO MYjTRW5ITVJ?
human NTERA-S-cl-D1 cell NUW1bWF5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHXrNYdKdmirYnn0bY9vKG:oIHj1cYFvKE6WRWLBMXMu[2xvREGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk45QDh6IN88US=> MYjTRW5ITVJ?
human EVSA-T cell NEPQUolIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEO0cldKdmirYnn0bY9vKG:oIHj1cYFvKEWYU1GtWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjl{MESg{txO NEPvWJRUSU6JRWK=
human NALM-6 cell M1TKNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NI\tN3dKdmirYnn0bY9vKG:oIHj1cYFvKE6DTF2tOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NiCLQ{WwQVE{NjB7Mkmg{txO NWHMNG9QW0GQR1XS
human KMOE-2 cell NYTKVmFoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEe0em5KdmirYnn0bY9vKG:oIHj1cYFvKEuPT1WtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjFyOUKg{txO NFnSb25USU6JRWK=
human HL-60 cell NX3FT|ZJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mk[0TY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlM{ODhizszN NHLpN5JUSU6JRWK=
human D-542MG cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWn4[3NSUW6qaXLpeIlwdiCxZjDoeY1idiCGLUW0Nm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTNwNEOwOkDPxE1? MlT4V2FPT0WU
human L-363 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{flR2lvcGmkaYTpc44hd2ZiaIXtZY4hVC1|NkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{42PTh|IN88US=> MYfTRW5ITVJ?
human CMK cell NIjocXRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2LzbWlvcGmkaYTpc44hd2ZiaIXtZY4hS02NIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuO|Q{PiEQvF2= NX\kV5ZjW0GQR1XS
human IMR-5 cell NVfDUWZ3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NW\yV5ZKUW6qaXLpeIlwdiCxZjDoeY1idiCLTWKtOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{Njd6NEmg{txO MYjTRW5ITVJ?
human A101D cell NFvoWG1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEi0fG5KdmirYnn0bY9vKG:oIHj1cYFvKEFzMEHEJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvQDJyNzFOwG0> NYqxXVh5W0GQR1XS
human MOLT-16 cell MljGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHvzZYVKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy57Nk[1JO69VQ>? MVnTRW5ITVJ?
human LU-139 cell M1ztdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGxWNTF|OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG0MlA1PDRizszN MoT5V2FPT0WU
human OVCAR-4 cell NYGxR49ZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV7iWlNbUW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk01KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTRwN{[wOEDPxE1? NH34NlVUSU6JRWK=
human BC-3 cell M323cmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkjHTY5pcWKrdHnvckBw\iCqdX3hckBDSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUSuO|k5OiEQvF2= Mo\YV2FPT0WU
PC12 cells M3XENmZ2dmO2aX;uJIF{e2G7 MWjDfZRweHKxdHXjeIl3\SCjY4Tpeol1gSCxbjDyZZQhfHWwaXPhcZlkcW5idILlZZRm\CC{YYSgdIhmd2Oqcn;tc4N6fG:vYTDj[YxtKGyrbnWgVGMyOiCocn;tJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEWwZH;wcIF{dWmlIILleIlkfWy3bTDzeJJme3NuIFXDOVA:OTVizszN NGXJOIIyPjByMkK4PC=>
human D-336MG cell M1LydWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUDJcohq[mm2aX;uJI9nKGi3bXHuJGQuOzN4TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4yOTN2IN88US=> NVuwXoV{W0GQR1XS
human BC-1 cell NYS0cmFQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkTKTY5pcWKrdHnvckBw\iCqdX3hckBDSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUWuNVk5KM7:TR?= NYXrWmRPW0GQR1XS
human KE-37 cell MnvnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlPyTY5pcWKrdHnvckBw\iCqdX3hckBMTS1|NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlI5OjRizszN M3yzR3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Salubrinal inhibits HSV replication in a mouse cornea infection model. Compared to vehicle control, topical Salubrinal treatment significantly reduced the viral titer recovered from eye swabs of infected animals. [1] I.C.V. administration of Salubrinal significantly modified the homeostatic sleep response. [3]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: PC12
  • Concentrations: 0-100 μM
  • Incubation Time: 48 hours
  • Method: PC12 cells are plated in 384-well plates at 5000 cells per well in 40μL phenol red-freemedium containing 3μg/ml Tm to induce ER stress. 100 nL of the DiverSet E (5 mg/mlin DMSO) or National Cancer Institute’s (NCI) Structural Diversity set and Open Collections (10 mM in DMSO) (NCI) are added to the wells by robotic pin transfer. After 48 hours, cell viability is assessed using a luminescence-based ATP assay. DMSO- and zVAD.fmk-treated wells on each plate served as negative and positive controls for rescue from ER stress-induced ATP loss, respectively.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Eight-week-old male CD-1 outbred mice
  • Formulation: in DMEM
  • Dosages: 75μM
  • Administration: On cornea
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 95 mg/mL (197.99 mM)
Ethanol 2 mg/mL (4.16 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 479.81
Formula

C21H17Cl3N4OS

CAS No. 405060-95-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID