Salubrinal

Catalog No.S2923

Salubrinal Chemical Structure

Molecular Weight(MW): 479.81

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

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In DMSO USD 280 In stock
USD 147 In stock
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Cited by 7 Publications

3 Customer Reviews

  • AngII (30 minutes)-induced Akt activation was attenuated by the ER stress inhibitors 4-PBA (5 mM, 2 hours), TUDCA (300 µg/ml, 1 hour), and salubrinal (30 µM, 1 hour) (n=5; *P<0.01 versus con, #P<0.05 versus Ang)

    J Am Soc Nephrol, 2015, 26(8):1839-54. . Salubrinal purchased from Selleck.

    PC-3 and HCT-116 p53+/+ cells were treated with 3-AWA and/or salubrinal for the indicated time point. The protein-specific antibodies were used to analyze the expression of the given proteins through immunoblotting.

    Oncogenesis, 2017, 6(5):e341. Salubrinal purchased from Selleck.

  • HEK293 cells were transfected with or without Flag-VP1 for 24 h, then treated with d Salubrinal (Sal, 75 μM) for 8 h followed by immunoblot detection. All data in this figure represent the mean ± SEM of three independent experiments. *p<0.05; ***p<0.01.

    Neurotox Res, 2017, 31(2):204-217. Salubrinal purchased from Selleck.

Purity & Quality Control

Choose Selective PERK Inhibitors

Biological Activity

Description Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Targets
eIF2α [1]
(Cell-free assay)
In vitro

Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ∼ 15 μM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. However, Salubrinal is not a general apoptosis inhibitor. Salubrinal induced rapid and robust eIF2α phosphorylation and its downstream effects in PC12 cells, including down-regulation of cyclin D1 and up-regulation of GADD34 and CHOP, two proteins whose expression is induced by eIF2α phosphorylation. Salubrinal inhibits eIF2α dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ~ 3μM by inhibiting eIF2α dephosphorylation. [1] Salubrinal increased non-rapid eye movement (NREM) sleep. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human LP-1 cell M33hfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3XIUmlvcGmkaYTpc44hd2ZiaIXtZY4hVFBvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuN|cyOTJizszN M2PsXHNCVkeHUh?=
human 697 cell NUToenpWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4rhUGlvcGmkaYTpc44hd2ZiaIXtZY4hPjl5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz65PFc5QCEQvF2= MmLiV2FPT0WU
human ALL-PO cell MkPWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUPJcohq[mm2aX;uJI9nKGi3bXHuJGFNVC2STzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNFg3PTVizszN M1TxbXNCVkeHUh?=
human ML-2 cell NHqzOYpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlnRTY5pcWKrdHnvckBw\iCqdX3hckBOVC1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND62NVg{OyEQvF2= Ml3oV2FPT0WU
human LB2241-RCC cell M2THfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2rP[mlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{MkSxMXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwOUi1O|Ih|ryP MXnTRW5ITVJ?
human Becker cell NELTdI1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEXiUIJKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzl2MEGg{txO NFntVFNUSU6JRWK=
human NEC8 cell NIPmOWdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVnyXW9MUW6qaXLpeIlwdiCxZjDoeY1idiCQRVO4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok4xPTN|MTFOwG0> NHyye4VUSU6JRWK=
human Daudi cell MlLVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlnoTY5pcWKrdHnvckBw\iCqdX3hckBF[XWmaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uN|M3QTlizszN MlfpV2FPT0WU
human MHH-PREB-1 cell NXu5RoVrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYjJcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2SUlXCMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03Njd6OEG3JO69VQ>? Mn7IV2FPT0WU
human NCI-H510A cell MlWxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXj3fpo{UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFUyOEFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15LkCzOVM2KM7:TR?= NGL6eWZUSU6JRWK=
human NCI-H720 cell NV3Cb5lRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYPESWRDUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFczOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwNUeyOlgh|ryP NUfHW5pMW0GQR1XS
human MRK-nu-1 cell Mn7qS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mk\WTY5pcWKrdHnvckBw\iCqdX3hckBOWktvboWtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPzVzN{Gg{txO M{HZT3NCVkeHUh?=
human LB2518-MEL cell NHXoSGdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX:2NJhmUW6qaXLpeIlwdiCxZjDoeY1idiCOQkK1NVguVUWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz65O|MzPiEQvF2= MVPTRW5ITVJ?
human BE-13 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVXJcohq[mm2aX;uJI9nKGi3bXHuJGJGNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD6yOlg1KM7:TR?= NH[xOWFUSU6JRWK=
human A3-KAW cell M1\o[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NY\qb3Z3UW6qaXLpeIlwdiCxZjDoeY1idiCDMz3LRXch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjR|Mki5JO69VQ>? NIr6cHpUSU6JRWK=
human ST486 cell NWf4S4xET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MULJcohq[mm2aX;uJI9nKGi3bXHuJHNVPDh4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD61N|Y5KM7:TR?= NGi5SnFUSU6JRWK=
human ES8 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3SwWmlvcGmkaYTpc44hd2ZiaIXtZY4hTVN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD62OFM{QSEQvF2= MXjTRW5ITVJ?
human HT cell MmPDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mly1TY5pcWKrdHnvckBw\iCqdX3hckBJXCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRThwOUSxPFUh|ryP NXftdWFzW0GQR1XS
human HAL-01 cell NFfMVJZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmDqTY5pcWKrdHnvckBw\iCqdX3hckBJSUxvMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlMyPTB3IN88US=> NHu5[4xUSU6JRWK=
human EB-3 cell NIni[m1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1rvUGlvcGmkaYTpc44hd2ZiaIXtZY4hTUJvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUmuOlI2PzJizszN MXLTRW5ITVJ?
human EW-1 cell M3zvS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX7zeoQ6UW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU44OTJ2IN88US=> MljQV2FPT0WU
human BL-41 cell NHfYcYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWPJcohq[mm2aX;uJI9nKGi3bXHuJGJNNTRzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT63PFA1QSEQvF2= MWfTRW5ITVJ?
Ramos-2G6-4C10 cell NF3OS5FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2fDcGlvcGmkaYTpc44hd2ZiaIXtZY4hWmGvb4OtNmc3NTSFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlkxOzF3IN88US=> NUexdWpzW0GQR1XS
human DOHH-2 cell NULhTYFmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX\jcYM5UW6qaXLpeIlwdiCxZjDoeY1idiCGT1jIMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC5{Mk[yJO69VQ>? MVjTRW5ITVJ?
MONO-MAC-6 cell MkjHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFz5UYpKdmirYnn0bY9vKG:oIHj1cYFvKE2RTl:tUWFENTZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD61OFg{KM7:TR?= NXzCdVB4W0GQR1XS
human NKM-1 cell NYjMemUxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{X6T2lvcGmkaYTpc44hd2ZiaIXtZY4hVkuPLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE43OTl4IN88US=> NGXOSWRUSU6JRWK=
human HEL cell Mlj2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGnFbVNKdmirYnn0bY9vKG:oIHj1cYFvKEiHTDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlYzPTJizszN NXjoPYdFW0GQR1XS
human 8-MG-BA cell NUXXbFVQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXfDN|M6UW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwOUm5PUDPxE1? NXHrdo14W0GQR1XS
human K-562 cell NHmzZmNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXm0[2V6UW6qaXLpeIlwdiCxZjDoeY1idiCNLUW2NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjBzOUGg{txO MXXTRW5ITVJ?
human LXF-289 cell NWrMfHNYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGX4UHdKdmirYnn0bY9vKG:oIHj1cYFvKEy[Rj2yPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS5zNUS3JO69VQ>? MYDTRW5ITVJ?
human HC-1 cell NHfGNJpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmLZTY5pcWKrdHnvckBw\iCqdX3hckBJSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuNVU1PyEQvF2= MoOwV2FPT0WU
human MC116 cell M4HKVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWD3PVVGUW6qaXLpeIlwdiCxZjDoeY1idiCPQ{GxOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjJyN{Og{txO MWLTRW5ITVJ?
human TE-12 cell MoXaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4HwV2lvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU4{OzV5IN88US=> M4nWbXNCVkeHUh?=
human BV-173 cell NHXORlRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnHVTY5pcWKrdHnvckBw\iCqdX3hckBDXi1zN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU42ODJzIN88US=> NUXYPWFMW0GQR1XS
human NCCIT cell M1rDUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGK4dGtKdmirYnn0bY9vKG:oIHj1cYFvKE6FQ1nUJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPjB|OTFOwG0> Mm\2V2FPT0WU
human CESS cell M3W4[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVXkZlBjUW6qaXLpeIlwdiCxZjDoeY1idiCFRWPTJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPjZ4MjFOwG0> M2jpbXNCVkeHUh?=
human HUTU-80 cell M3T1[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWCyRo43UW6qaXLpeIlwdiCxZjDoeY1idiCKVWTVMVgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwNkewOEDPxE1? NWqwV3hCW0GQR1XS
human IST-SL2 cell NHq4SY9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3roVGlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjd5MESg{txO NVzKS|IzW0GQR1XS
human ATN-1 cell NYq2RoY2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4DHTmlvcGmkaYTpc44hd2ZiaIXtZY4hSVSQLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk4xOjJ4IN88US=> MWHTRW5ITVJ?
human HCC1599 cell MnjwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVjHVYU2UW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OxOVk6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwMUC5OEDPxE1? MV3TRW5ITVJ?
human NTERA-S-cl-D1 cell M4PaXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGrTZnJKdmirYnn0bY9vKG:oIHj1cYFvKE6WRWLBMXMu[2xvREGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk45QDh6IN88US=> NIPQNYlUSU6JRWK=
human EVSA-T cell MonjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGVXW0FvVDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGyMlkzODRizszN NFG4No1USU6JRWK=
human NALM-6 cell NVf1NoQyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{LIdmlvcGmkaYTpc44hd2ZiaIXtZY4hVkGOTT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvKEmFNUC9NVMvODl{OTFOwG0> NE\aSHhUSU6JRWK=
human KMOE-2 cell MmLRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4C5TGlvcGmkaYTpc44hd2ZiaIXtZY4hU02RRT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvOTB7MjFOwG0> M3mwWHNCVkeHUh?=
human HL-60 cell M2i0bGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUm3dmYzUW6qaXLpeIlwdiCxZjDoeY1idiCKTD22NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjN|MEig{txO NWnsNIM3W0GQR1XS
human D-542MG cell NEDrVJpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkTKTY5pcWKrdHnvckBw\iCqdX3hckBFNTV2Ml3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvPDNyNjFOwG0> NYX0V2FzW0GQR1XS
human L-363 cell M2G5U2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFrJSFhKdmirYnn0bY9vKG:oIHj1cYFvKExvM{[zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvPTV6MzFOwG0> NUHpSHp5W0GQR1XS
human CMK cell MmnZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXzJcohq[mm2aX;uJI9nKGi3bXHuJGNOUyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF|Lke0N|Yh|ryP Mn3TV2FPT0WU
human IMR-5 cell NFy1RVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{nR[WlvcGmkaYTpc44hd2ZiaIXtZY4hUU2ULUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{44QDR7IN88US=> NXvldVA4W0GQR1XS
human A101D cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2TZXGlvcGmkaYTpc44hd2ZiaIXtZY4hSTFyMVSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{45OjB5IN88US=> NHvPWJpUSU6JRWK=
human MOLT-16 cell M3L0WWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIH2OZhKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy57Nk[1JO69VQ>? M{TDUnNCVkeHUh?=
human LU-139 cell Ml\GS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2naOGlvcGmkaYTpc44hd2ZiaIXtZY4hVFVvMUO5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvODR2NDFOwG0> MoDyV2FPT0WU
human OVCAR-4 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M37EXmlvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKtOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE1Njd4MESg{txO NEnUO45USU6JRWK=
human BC-3 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUHJcohq[mm2aX;uJI9nKGi3bXHuJGJENTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zND63PVgzKM7:TR?= NVO3Oml2W0GQR1XS
PC12 cells MXrGeY5kfGmxbjDhd5NigQ>? MYrDfZRweHKxdHXjeIl3\SCjY4Tpeol1gSCxbjDyZZQhfHWwaXPhcZlkcW5idILlZZRm\CC{YYSgdIhmd2Oqcn;tc4N6fG:vYTDj[YxtKGyrbnWgVGMyOiCocn;tJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEWwZH;wcIF{dWmlIILleIlkfWy3bTDzeJJme3NuIFXDOVA:OTVizszN NXz6emZWOTZyMEKyPFg>
human D-336MG cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUmzS2hsUW6qaXLpeIlwdiCxZjDoeY1idiCGLUOzOm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTVwMUGzOEDPxE1? M1OyPHNCVkeHUh?=
human BC-1 cell NX7RenVGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3TCOWlvcGmkaYTpc44hd2ZiaIXtZY4hSkNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlE6QCEQvF2= M2Hh[3NCVkeHUh?=
human KE-37 cell NHOxOFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXjJcohq[mm2aX;uJI9nKGi3bXHuJGtGNTN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUWuNlgzPCEQvF2= M{TDRnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Salubrinal inhibits HSV replication in a mouse cornea infection model. Compared to vehicle control, topical Salubrinal treatment significantly reduced the viral titer recovered from eye swabs of infected animals. [1] I.C.V. administration of Salubrinal significantly modified the homeostatic sleep response. [3]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: PC12
  • Concentrations: 0-100 μM
  • Incubation Time: 48 hours
  • Method: PC12 cells are plated in 384-well plates at 5000 cells per well in 40μL phenol red-freemedium containing 3μg/ml Tm to induce ER stress. 100 nL of the DiverSet E (5 mg/mlin DMSO) or National Cancer Institute’s (NCI) Structural Diversity set and Open Collections (10 mM in DMSO) (NCI) are added to the wells by robotic pin transfer. After 48 hours, cell viability is assessed using a luminescence-based ATP assay. DMSO- and zVAD.fmk-treated wells on each plate served as negative and positive controls for rescue from ER stress-induced ATP loss, respectively.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Eight-week-old male CD-1 outbred mice
  • Formulation: in DMEM
  • Dosages: 75μM
  • Administration: On cornea
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 95 mg/mL (197.99 mM)
Ethanol 2 mg/mL (4.16 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 479.81
Formula

C21H17Cl3N4OS

CAS No. 405060-95-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID