Salubrinal

Catalog No.S2923

Salubrinal Chemical Structure

Molecular Weight(MW): 479.81

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

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In DMSO USD 280 In stock
USD 147 In stock
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  • AngII (30 minutes)-induced Akt activation was attenuated by the ER stress inhibitors 4-PBA (5 mM, 2 hours), TUDCA (300 µg/ml, 1 hour), and salubrinal (30 µM, 1 hour) (n=5; *P<0.01 versus con, #P<0.05 versus Ang)

    J Am Soc Nephrol, 2015, 26(8):1839-54. . Salubrinal purchased from Selleck.

    PC-3 and HCT-116 p53+/+ cells were treated with 3-AWA and/or salubrinal for the indicated time point. The protein-specific antibodies were used to analyze the expression of the given proteins through immunoblotting.

    Oncogenesis, 2017, 6(5):e341. Salubrinal purchased from Selleck.

  • HEK293 cells were transfected with or without Flag-VP1 for 24 h, then treated with d Salubrinal (Sal, 75 μM) for 8 h followed by immunoblot detection. All data in this figure represent the mean ± SEM of three independent experiments. *p<0.05; ***p<0.01.

    Neurotox Res, 2017, 31(2):204-217. Salubrinal purchased from Selleck.

Purity & Quality Control

Choose Selective PERK Inhibitors

Biological Activity

Description Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Targets
eIF2α [1]
(Cell-free assay)
In vitro

Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ∼ 15 μM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. However, Salubrinal is not a general apoptosis inhibitor. Salubrinal induced rapid and robust eIF2α phosphorylation and its downstream effects in PC12 cells, including down-regulation of cyclin D1 and up-regulation of GADD34 and CHOP, two proteins whose expression is induced by eIF2α phosphorylation. Salubrinal inhibits eIF2α dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ~ 3μM by inhibiting eIF2α dephosphorylation. [1] Salubrinal increased non-rapid eye movement (NREM) sleep. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human LP-1 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXHJcohq[mm2aX;uJI9nKGi3bXHuJGxRNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkO3NVEzKM7:TR?= M4CyT3NCVkeHUh?=
human 697 cell NUPaN|FUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXrJcohq[mm2aX;uJI9nKGi3bXHuJFY6PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwOUi3PFgh|ryP NYDCcWR4W0GQR1XS
human ALL-PO cell NXvq[YxDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4DoW2lvcGmkaYTpc44hd2ZiaIXtZY4hSUyOLWDPJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4xQDZ3NTFOwG0> NIHwWHRUSU6JRWK=
human ML-2 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVvCcmo4UW6qaXLpeIlwdiCxZjDoeY1idiCPTD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE43OTh|MzFOwG0> MknsV2FPT0WU
human LB2241-RCC cell MnfjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVXJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjJ2MT3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Njl6NUeyJO69VQ>? MVHTRW5ITVJ?
human Becker cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEnRR3pKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzl2MEGg{txO NUfjTItLW0GQR1XS
human NEC8 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWHVXW8zUW6qaXLpeIlwdiCxZjDoeY1idiCQRVO4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok4xPTN|MTFOwG0> MmfvV2FPT0WU
human Daudi cell MkHOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXHoUpNQUW6qaXLpeIlwdiCxZjDoeY1idiCGYYXkbUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvOzN4OUmg{txO M1rDR3NCVkeHUh?=
human MHH-PREB-1 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXv6PWRnUW6qaXLpeIlwdiCxZjDoeY1idiCPSFitVHJGSi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj63PFgyPyEQvF2= Mm\EV2FPT0WU
human NCI-H510A cell M{PUSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4P0eGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NVBCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py5yM{WzOUDPxE1? MknMV2FPT0WU
human NCI-H720 cell M1vhUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnvmTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEeyNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPTd{Nkig{txO MXLTRW5ITVJ?
human MRK-nu-1 cell Mom3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWfJcohq[mm2aX;uJI9nKGi3bXHuJG1TUy2wdT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{44PTF5MTFOwG0> MlzMV2FPT0WU
human LB2518-MEL cell Mlr1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{TnTmlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{NUG4MW1GVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwOUezNlYh|ryP MVXTRW5ITVJ?
human BE-13 cell Mm\1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFTNfXdKdmirYnn0bY9vKG:oIHj1cYFvKEKHLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4zPjh2IN88US=> MXPTRW5ITVJ?
human A3-KAW cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYjJcohq[mm2aX;uJI9nKGi3bXHuJGE{NUuDVzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuOFMzQDlizszN NYjScJo4W0GQR1XS
human ST486 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlfqTY5pcWKrdHnvckBw\iCqdX3hckBUXDR6NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuOVM3QCEQvF2= NIS3VVRUSU6JRWK=
human ES8 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnXQTY5pcWKrdHnvckBw\iCqdX3hckBGWzhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16Lk[0N|M6KM7:TR?= NWfsbYk3W0GQR1XS
human HT cell MnvWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXLKe|ZKUW6qaXLpeIlwdiCxZjDoeY1idiCKVDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuPVQyQDVizszN M3fUfnNCVkeHUh?=
human HAL-01 cell MoTiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYPJcohq[mm2aX;uJI9nKGi3bXHuJGhCVC1yMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUmuN|E2ODVizszN MW\TRW5ITVJ?
human EB-3 cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXvJcohq[mm2aX;uJI9nKGi3bXHuJGVDNTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17Lk[yOVczKM7:TR?= Mm\DV2FPT0WU
human EW-1 cell NX3t[pBuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYnJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17LkexNlQh|ryP NGHH[olUSU6JRWK=
human BL-41 cell MnrCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVvJcohq[mm2aX;uJI9nKGi3bXHuJGJNNTRzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT63PFA1QSEQvF2= MVHTRW5ITVJ?
Ramos-2G6-4C10 cell NFTIOXdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVrJcohq[mm2aX;uJI9nKGi3bXHuJHJidW:|LULHOk01SzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT65NFMyPSEQvF2= MUnTRW5ITVJ?
human DOHH-2 cell NWfpO3JzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUHJOmtUUW6qaXLpeIlwdiCxZjDoeY1idiCGT1jIMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC5{Mk[yJO69VQ>? MknEV2FPT0WU
MONO-MAC-6 cell NWLrR|JXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NU\n[Yh4UW6qaXLpeIlwdiCxZjDoeY1idiCPT17PMW1CSy14IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUCuOVQ5OyEQvF2= MnXkV2FPT0WU
human NKM-1 cell M2j5VGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlmxTY5pcWKrdHnvckBw\iCqdX3hckBPU01vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlYyQTZizszN MmO3V2FPT0WU
human HEL cell NGTsZ5JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUXkR|E2UW6qaXLpeIlwdiCxZjDoeY1idiCKRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE43OjV{IN88US=> M4rNWnNCVkeHUh?=
human 8-MG-BA cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYHCO21[UW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwOUm5PUDPxE1? MnPXV2FPT0WU
human K-562 cell NIjxNVBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWTNNFhUUW6qaXLpeIlwdiCxZjDoeY1idiCNLUW2NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjBzOUGg{txO M3\4[nNCVkeHUh?=
human LXF-289 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVrwOm96UW6qaXLpeIlwdiCxZjDoeY1idiCOWF[tNlg6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwMUW0O{DPxE1? MkLDV2FPT0WU
human HC-1 cell Ml7CS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFy2WGlKdmirYnn0bY9vKG:oIHj1cYFvKEiFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU4yPTR5IN88US=> NWfB[3RQW0GQR1XS
human MC116 cell NX\hPGpDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH7lSo5KdmirYnn0bY9vKG:oIHj1cYFvKE2FMUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOjB5MzFOwG0> MUPTRW5ITVJ?
human TE-12 cell MkDBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkHsTY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlM{PTdizszN NVvicXh1W0GQR1XS
human BV-173 cell Ml\TS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2rXdmlvcGmkaYTpc44hd2ZiaIXtZY4hSlZvMUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPTB{MTFOwG0> MnHhV2FPT0WU
human NCCIT cell NU[3WmhZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1LOcmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOFSWSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU43ODN7IN88US=> MVjTRW5ITVJ?
human CESS cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1XTU2lvcGmkaYTpc44hd2ZiaIXtZY4hS0WVUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlY3PjJizszN MmrWV2FPT0WU
human HUTU-80 cell NYjrS4U2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF;WRVZKdmirYnn0bY9vKG:oIHj1cYFvKEiXVGWtPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS54N{C0JO69VQ>? M3XYT3NCVkeHUh?=
human IST-SL2 cell MnnPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXrsUHJNUW6qaXLpeIlwdiCxZjDoeY1idiCLU2StV2wzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwN{ewOEDPxE1? MXXTRW5ITVJ?
human ATN-1 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVXJcohq[mm2aX;uJI9nKGi3bXHuJGFVVi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUKuNFIzPiEQvF2= MXnTRW5ITVJ?
human HCC1599 cell NW\x[npTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVXJcohq[mm2aX;uJI9nKGi3bXHuJGhESzF3OUmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk4yODl2IN88US=> NFK3bllUSU6JRWK=
human NTERA-S-cl-D1 cell NETEcYtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml3lTY5pcWKrdHnvckBw\iCqdX3hckBPXEWUQT3TMYNtNURzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUKuPFg5QCEQvF2= MXfTRW5ITVJ?
human EVSA-T cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHT5SVZKdmirYnn0bY9vKG:oIHj1cYFvKEWYU1GtWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjl{MESg{txO NUXKWmxSW0GQR1XS
human NALM-6 cell MlrTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYfJcohq[mm2aX;uJI9nKGi3bXHuJG5CVE1vNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MkBKSzVyPUGzMlA6OjlizszN MnjKV2FPT0WU
human KMOE-2 cell NEDpc3FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NInKR49KdmirYnn0bY9vKG:oIHj1cYFvKEuPT1WtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjFyOUKg{txO MmjhV2FPT0WU
human HL-60 cell MmLuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXHJcohq[mm2aX;uJI9nKGi3bXHuJGhNNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuN|MxQCEQvF2= MV3TRW5ITVJ?
human D-542MG cell MlTQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUnvT41bUW6qaXLpeIlwdiCxZjDoeY1idiCGLUW0Nm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTNwNEOwOkDPxE1? NF\qTlBUSU6JRWK=
human L-363 cell MofES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnnpTY5pcWKrdHnvckBw\iCqdX3hckBNNTN4MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlU2QDNizszN MYnTRW5ITVJ?
human CMK cell NULLcYh7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWizU4NtUW6qaXLpeIlwdiCxZjDoeY1idiCFTVugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{44PDN4IN88US=> MXPTRW5ITVJ?
human IMR-5 cell NGf1O2dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NY\BWZN{UW6qaXLpeIlwdiCxZjDoeY1idiCLTWKtOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{Njd6NEmg{txO MnnrV2FPT0WU
human A101D cell NVS3R3VqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVXJcohq[mm2aX;uJI9nKGi3bXHuJGEyODGGIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuPFIxPyEQvF2= NYrHTJk4W0GQR1XS
human MOLT-16 cell MonrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEiwS2ZKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy57Nk[1JO69VQ>? M3zBVnNCVkeHUh?=
human LU-139 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2DWZmlvcGmkaYTpc44hd2ZiaIXtZY4hVFVvMUO5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvODR2NDFOwG0> NYH2U3R4W0GQR1XS
human OVCAR-4 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFnPO|ZKdmirYnn0bY9vKG:oIHj1cYFvKE:YQ1HSMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPC55NkC0JO69VQ>? NEi0NotUSU6JRWK=
human BC-3 cell NY\GeGV2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mnm0TY5pcWKrdHnvckBw\iCqdX3hckBDSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUSuO|k5OiEQvF2= NF;aR4dUSU6JRWK=
PC12 cells M2DuW2Z2dmO2aX;uJIF{e2G7 NUfOd4htS3m2b4Dyc5Rm[3SrdnWgZYN1cX[rdImgc44hemG2IIT1colk[W27Y3nuJJRz\WG2ZXSgdoF1KHCqZX;jbJJwdW:leYTvcYEh[2WubDDsbY5mKFCFMUKg[pJwdSCjcH;weI9{cXNiaX7keYNm\CCkeTDFcoRweGyjc33pZ{Bz\XSrY4XseY0he3S{ZYPzMEBGSzVyPUG1JO69VQ>? M4DOOVE3ODB{Mki4
human D-336MG cell MojUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXrJcohq[mm2aX;uJI9nKGi3bXHuJGQuOzN4TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4yOTN2IN88US=> NXvnfIUzW0GQR1XS
human BC-1 cell M1TjUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2\6cGlvcGmkaYTpc44hd2ZiaIXtZY4hSkNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlE6QCEQvF2= NWLsfHpxW0GQR1XS
human KE-37 cell MmW0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4G4TGlvcGmkaYTpc44hd2ZiaIXtZY4hU0VvM{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4zQDJ2IN88US=> NV\yflNrW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Salubrinal inhibits HSV replication in a mouse cornea infection model. Compared to vehicle control, topical Salubrinal treatment significantly reduced the viral titer recovered from eye swabs of infected animals. [1] I.C.V. administration of Salubrinal significantly modified the homeostatic sleep response. [3]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: PC12
  • Concentrations: 0-100 μM
  • Incubation Time: 48 hours
  • Method: PC12 cells are plated in 384-well plates at 5000 cells per well in 40μL phenol red-freemedium containing 3μg/ml Tm to induce ER stress. 100 nL of the DiverSet E (5 mg/mlin DMSO) or National Cancer Institute’s (NCI) Structural Diversity set and Open Collections (10 mM in DMSO) (NCI) are added to the wells by robotic pin transfer. After 48 hours, cell viability is assessed using a luminescence-based ATP assay. DMSO- and zVAD.fmk-treated wells on each plate served as negative and positive controls for rescue from ER stress-induced ATP loss, respectively.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Eight-week-old male CD-1 outbred mice
  • Formulation: in DMEM
  • Dosages: 75μM
  • Administration: On cornea
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 95 mg/mL (197.99 mM)
Ethanol 2 mg/mL (4.16 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 479.81
Formula

C21H17Cl3N4OS

CAS No. 405060-95-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID