Salubrinal

Catalog No.S2923

Salubrinal Chemical Structure

Molecular Weight(MW): 479.81

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

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In DMSO USD 280 In stock
USD 147 In stock
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Cited by 7 Publications

3 Customer Reviews

  • AngII (30 minutes)-induced Akt activation was attenuated by the ER stress inhibitors 4-PBA (5 mM, 2 hours), TUDCA (300 µg/ml, 1 hour), and salubrinal (30 µM, 1 hour) (n=5; *P<0.01 versus con, #P<0.05 versus Ang)

    J Am Soc Nephrol, 2015, 26(8):1839-54. . Salubrinal purchased from Selleck.

    PC-3 and HCT-116 p53+/+ cells were treated with 3-AWA and/or salubrinal for the indicated time point. The protein-specific antibodies were used to analyze the expression of the given proteins through immunoblotting.

    Oncogenesis, 2017, 6(5):e341. Salubrinal purchased from Selleck.

  • HEK293 cells were transfected with or without Flag-VP1 for 24 h, then treated with d Salubrinal (Sal, 75 μM) for 8 h followed by immunoblot detection. All data in this figure represent the mean ± SEM of three independent experiments. *p<0.05; ***p<0.01.

    Neurotox Res, 2017, 31(2):204-217. Salubrinal purchased from Selleck.

Purity & Quality Control

Choose Selective PERK Inhibitors

Biological Activity

Description Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Targets
eIF2α [1]
(Cell-free assay)
In vitro

Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ∼ 15 μM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. However, Salubrinal is not a general apoptosis inhibitor. Salubrinal induced rapid and robust eIF2α phosphorylation and its downstream effects in PC12 cells, including down-regulation of cyclin D1 and up-regulation of GADD34 and CHOP, two proteins whose expression is induced by eIF2α phosphorylation. Salubrinal inhibits eIF2α dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ~ 3μM by inhibiting eIF2α dephosphorylation. [1] Salubrinal increased non-rapid eye movement (NREM) sleep. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human LP-1 cell MmDSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIPZPJFKdmirYnn0bY9vKG:oIHj1cYFvKEySLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlM4OTF{IN88US=> NHX1PFRUSU6JRWK=
human 697 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVjCeGZXUW6qaXLpeIlwdiCxZjDoeY1idiB4OUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlk5Pzh6IN88US=> MWTTRW5ITVJ?
human ALL-PO cell Mo\FS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVHJcohq[mm2aX;uJI9nKGi3bXHuJGFNVC2STzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNFg3PTVizszN NGj0PWNUSU6JRWK=
human ML-2 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mk\VTY5pcWKrdHnvckBw\iCqdX3hckBOVC1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND62NVg{OyEQvF2= MWXTRW5ITVJ?
human LB2241-RCC cell MoC1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkXyTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC57OEW3NkDPxE1? MYLTRW5ITVJ?
human Becker cell NW\1ZWF1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoSzTY5pcWKrdHnvckBw\iCqdX3hckBD\WOtZYKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Mlc6PDBzIN88US=> NYC0RW0xW0GQR1XS
human NEC8 cell M3H5Umdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1nHc2lvcGmkaYTpc44hd2ZiaIXtZY4hVkWFODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uNFU{OzFizszN MWfTRW5ITVJ?
human Daudi cell MkfZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWjpV4pkUW6qaXLpeIlwdiCxZjDoeY1idiCGYYXkbUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvOzN4OUmg{txO M2r6SnNCVkeHUh?=
human MHH-PREB-1 cell MmH4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEfJXlJKdmirYnn0bY9vKG:oIHj1cYFvKE2KSD3QVmVDNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Lke4PFE4KM7:TR?= Ml\mV2FPT0WU
human NCI-H510A cell M3vL[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUGwRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvODN3M{Wg{txO M3rKcXNCVkeHUh?=
human NCI-H720 cell NILkTnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWHYNYp1UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFczOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwNUeyOlgh|ryP NF;yUHFUSU6JRWK=
human MRK-nu-1 cell M2jnNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHfaV5hKdmirYnn0bY9vKG:oIHj1cYFvKE2USz3ueU0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py55NUG3NUDPxE1? NHTXeYtUSU6JRWK=
human LB2518-MEL cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2TnV2lvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{NUG4MW1GVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwOUezNlYh|ryP NXTlWlI3W0GQR1XS
human BE-13 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGXhPWlKdmirYnn0bY9vKG:oIHj1cYFvKEKHLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4zPjh2IN88US=> M2HsdXNCVkeHUh?=
human A3-KAW cell NXTFT|lET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFTiWJNKdmirYnn0bY9vKG:oIHj1cYFvKEF|LVvBW{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPDN{OEmg{txO NU\IOIZyW0GQR1XS
human ST486 cell M3nJNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUTJcohq[mm2aX;uJI9nKGi3bXHuJHNVPDh4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD61N|Y5KM7:TR?= NIXwdYRUSU6JRWK=
human ES8 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NU[5XW93UW6qaXLpeIlwdiCxZjDoeY1idiCHU{igZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlY1OzN7IN88US=> M3mwOXNCVkeHUh?=
human HT cell NVPiem44T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYPJcohq[mm2aX;uJI9nKGi3bXHuJGhVKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC57NEG4OUDPxE1? NVP1WZF5W0GQR1XS
human HAL-01 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoThTY5pcWKrdHnvckBw\iCqdX3hckBJSUxvMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlMyPTB3IN88US=> NYTXfGl3W0GQR1XS
human EB-3 cell NVrJOld{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWHaXHVDUW6qaXLpeIlwdiCxZjDoeY1idiCHQj2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU43OjV5MjFOwG0> M2L2WnNCVkeHUh?=
human EW-1 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnvJTY5pcWKrdHnvckBw\iCqdX3hckBGXy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT63NVI1KM7:TR?= MoL1V2FPT0WU
human BL-41 cell MlfYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGrtdm1KdmirYnn0bY9vKG:oIHj1cYFvKEKOLUSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU44QDB2OTFOwG0> NX\6bJBkW0GQR1XS
Ramos-2G6-4C10 cell MoOxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3f5cWlvcGmkaYTpc44hd2ZiaIXtZY4hWmGvb4OtNmc3NTSFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlkxOzF3IN88US=> MWfTRW5ITVJ?
human DOHH-2 cell NIPU[XNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUXadmlNUW6qaXLpeIlwdiCxZjDoeY1idiCGT1jIMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC5{Mk[yJO69VQ>? Mlu4V2FPT0WU
MONO-MAC-6 cell NYq4d3YzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX6wOnZOUW6qaXLpeIlwdiCxZjDoeY1idiCPT17PMW1CSy14IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUCuOVQ5OyEQvF2= NXvQPIl6W0GQR1XS
human NKM-1 cell NULBNlB[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIrwfZlKdmirYnn0bY9vKG:oIHj1cYFvKE6NTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvPjF7NjFOwG0> NG\qV29USU6JRWK=
human HEL cell NVLkb3RCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVH0RZNYUW6qaXLpeIlwdiCxZjDoeY1idiCKRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE43OjV{IN88US=> NHPYT2xUSU6JRWK=
human 8-MG-BA cell NEDIWmNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlriTY5pcWKrdHnvckBw\iCqdX3hckA5NU2JLVLBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvQTl7OTFOwG0> MVPTRW5ITVJ?
human K-562 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M334R2lvcGmkaYTpc44hd2ZiaIXtZY4hUy13NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU4xOTlzIN88US=> M3fXNHNCVkeHUh?=
human LXF-289 cell M3r5TGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUG4T2JmUW6qaXLpeIlwdiCxZjDoeY1idiCOWF[tNlg6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwMUW0O{DPxE1? NUjQUJlCW0GQR1XS
human HC-1 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHfr[JZKdmirYnn0bY9vKG:oIHj1cYFvKEiFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU4yPTR5IN88US=> NW[yUHMzW0GQR1XS
human MC116 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4PsNWlvcGmkaYTpc44hd2ZiaIXtZY4hVUNzMU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU4zODd|IN88US=> M4PtenNCVkeHUh?=
human TE-12 cell Mmn3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUPZc4dHUW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjN|NUeg{txO MnSyV2FPT0WU
human BV-173 cell NYS0U4hQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYjJcohq[mm2aX;uJI9nKGi3bXHuJGJXNTF5MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlUxOjFizszN NIfnZ4tUSU6JRWK=
human NCCIT cell NFnnbnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NELHSZdKdmirYnn0bY9vKG:oIHj1cYFvKE6FQ1nUJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPjB|OTFOwG0> M2nrWXNCVkeHUh?=
human CESS cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mmq0TY5pcWKrdHnvckBw\iCqdX3hckBETVOVIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuOlY3OiEQvF2= M1nmd3NCVkeHUh?=
human HUTU-80 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2\kbWlvcGmkaYTpc44hd2ZiaIXtZY4hUFWWVT24NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjZ5MESg{txO MVzTRW5ITVJ?
human IST-SL2 cell M4j2VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGH5SJhKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3TUFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS55N{C0JO69VQ>? NGDOS2xUSU6JRWK=
human ATN-1 cell NXvISllrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUPJcohq[mm2aX;uJI9nKGi3bXHuJGFVVi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUKuNFIzPiEQvF2= NFTiSIRUSU6JRWK=
human HCC1599 cell NVruPHpZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4DKXmlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUW5PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjFyOUSg{txO NH\M[lZUSU6JRWK=
human NTERA-S-cl-D1 cell NIOyV|dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlrUTY5pcWKrdHnvckBw\iCqdX3hckBPXEWUQT3TMYNtNURzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUKuPFg5QCEQvF2= M3P1V3NCVkeHUh?=
human EVSA-T cell MmjpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3XHZWlvcGmkaYTpc44hd2ZiaIXtZY4hTV[VQT3UJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvQTJyNDFOwG0> M3PObHNCVkeHUh?=
human NALM-6 cell NIXrZ|dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXn4fXl4UW6qaXLpeIlwdiCxZjDoeY1idiCQQVzNMVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS5iSVO1NF0yOy5yOUK5JO69VQ>? MmHJV2FPT0WU
human KMOE-2 cell NEfZXo5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGtOV0VvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlExQTJizszN NVfHRotwW0GQR1XS
human HL-60 cell NF[3VIJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlrKTY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlM{ODhizszN M1rxVHNCVkeHUh?=
human D-542MG cell NFHxW|NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2jzWmlvcGmkaYTpc44hd2ZiaIXtZY4hTC13NELNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjR|ME[g{txO MnjjV2FPT0WU
human L-363 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3rnWmlvcGmkaYTpc44hd2ZiaIXtZY4hVC1|NkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{42PTh|IN88US=> NYrxWmZNW0GQR1XS
human CMK cell NHPZNYpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEPrTIpKdmirYnn0bY9vKG:oIHj1cYFvKEOPSzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlc1OzZizszN NGLpflBUSU6JRWK=
human IMR-5 cell M2DGS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXzYR4lbUW6qaXLpeIlwdiCxZjDoeY1idiCLTWKtOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{Njd6NEmg{txO MVPTRW5ITVJ?
human A101D cell NFLMO|JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NU\y[4l2UW6qaXLpeIlwdiCxZjDoeY1idiCDMUCxSEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{Njh{MEeg{txO MWfTRW5ITVJ?
human MOLT-16 cell M3;wfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHjGXIZKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy57Nk[1JO69VQ>? NFXCZVlUSU6JRWK=
human LU-139 cell MkC2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJGxWNTF|OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG0MlA1PDRizszN M13hdHNCVkeHUh?=
human OVCAR-4 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF\tZ5lKdmirYnn0bY9vKG:oIHj1cYFvKE:YQ1HSMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPC55NkC0JO69VQ>? MVLTRW5ITVJ?
human BC-3 cell NXSzNoJwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGSybZlKdmirYnn0bY9vKG:oIHj1cYFvKEKFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE44QTh{IN88US=> MlXQV2FPT0WU
PC12 cells M1zHWGZ2dmO2aX;uJIF{e2G7 NX\JOHI6S3m2b4Dyc5Rm[3SrdnWgZYN1cX[rdImgc44hemG2IIT1colk[W27Y3nuJJRz\WG2ZXSgdoF1KHCqZX;jbJJwdW:leYTvcYEh[2WubDDsbY5mKFCFMUKg[pJwdSCjcH;weI9{cXNiaX7keYNm\CCkeTDFcoRweGyjc33pZ{Bz\XSrY4XseY0he3S{ZYPzMEBGSzVyPUG1JO69VQ>? MlWyNVYxODJ{OEi=
human D-336MG cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVnJcohq[mm2aX;uJI9nKGi3bXHuJGQuOzN4TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4yOTN2IN88US=> MULTRW5ITVJ?
human BC-1 cell NEexPYpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGnsZmxKdmirYnn0bY9vKG:oIHj1cYFvKEKFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4yQThizszN MWfTRW5ITVJ?
human KE-37 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3LPdGlvcGmkaYTpc44hd2ZiaIXtZY4hU0VvM{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4zQDJ2IN88US=> MXPTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Salubrinal inhibits HSV replication in a mouse cornea infection model. Compared to vehicle control, topical Salubrinal treatment significantly reduced the viral titer recovered from eye swabs of infected animals. [1] I.C.V. administration of Salubrinal significantly modified the homeostatic sleep response. [3]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: PC12
  • Concentrations: 0-100 μM
  • Incubation Time: 48 hours
  • Method: PC12 cells are plated in 384-well plates at 5000 cells per well in 40μL phenol red-freemedium containing 3μg/ml Tm to induce ER stress. 100 nL of the DiverSet E (5 mg/mlin DMSO) or National Cancer Institute’s (NCI) Structural Diversity set and Open Collections (10 mM in DMSO) (NCI) are added to the wells by robotic pin transfer. After 48 hours, cell viability is assessed using a luminescence-based ATP assay. DMSO- and zVAD.fmk-treated wells on each plate served as negative and positive controls for rescue from ER stress-induced ATP loss, respectively.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Eight-week-old male CD-1 outbred mice
  • Formulation: in DMEM
  • Dosages: 75μM
  • Administration: On cornea
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 95 mg/mL (197.99 mM)
Ethanol 2 mg/mL (4.16 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 479.81
Formula

C21H17Cl3N4OS

CAS No. 405060-95-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID