SB 200646

Catalog No.S2649 Synonyms: SB 200646A

For research use only.

SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.

SB 200646 Chemical Structure

CAS No. 143797-63-1

Purity & Quality Control

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Biological Activity

Description SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
Targets
5-HT2B (rat) [1]
(Cell-free assay)
5-HT2C (Rat) [1]
(Cell-free assay)
5-HT2A (rat) [1]
(Cell-free assay)
7.5(pKi) 6.9(pKi) 5.2(pKi)

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 53 mg/mL
(199.02 mM)
Ethanol 2 mg/mL
(7.51 mM)
Water ˂1 mg/mL

Chemical Information

Molecular Weight 266.30
Formula

C15H14N4O

CAS No. 143797-63-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1C=CC2=C1C=CC(=C2)NC(=O)NC3=CN=CC=C3

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

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% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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