SIS17

Catalog No.S6687

For research use only.

SIS17 is a mammalian histone deacetylase 11 (HDAC 11)-specific inhibitor with IC50 of 0.83 μM. SIS17 inhibits the demyristoylation of HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.

SIS17 Chemical Structure

CAS No. 2374313-54-7

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Biological Activity

Description SIS17 is a mammalian histone deacetylase 11 (HDAC 11)-specific inhibitor with IC50 of 0.83 μM. SIS17 inhibits the demyristoylation of HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
Targets
HDAC11 [1]
(Cell-free assay)
0.83 μM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 366.60
Formula

C21H38N2OS

 

CAS No. 2374313-54-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCCCCCCCCCCCCCNNC(=O)C1=CC=CS1

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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