SB273005

Catalog No.S7540

For research use only.

SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.

SB273005 Chemical Structure

CAS No. 205678-31-5

Selleck's SB273005 has been cited by 15 publications

Purity & Quality Control

Choose Selective Integrin Inhibitors

Biological Activity

Description SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
Targets
αvβ5 receptor [1]
(Cell-free assay)
αvβ3 receptor [1]
(Cell-free assay)
0.3 nM 1.2 nM
In vitro

In vitro, SB273005 inhibits human osteoclast-mediated bone resorption with IC50 of 11 nM. [1] In blood containing MDA-MB-231 cells, a combination of SB273005 and lamifiban inhibits tumor cell adhesion to vascular extracellular matrix (ECM). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK 293 cells NX3FWmNJTnWwY4Tpc44h[XO|YYm= MUPJcohq[mm2aX;uJI9nKF[rdILvcoVkfGmwIILlZ4VxfG:{LDDpcpRm\3KrbjDhcJBp[VZvYnX0ZVMh\XiycnXzd4VlKGmwIFjFT{AzQTNiY3XscJMtKEmFNUC9NE4xODBzNTFOwG0> NHTLOFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkS3O|M1Pyd-MUK0O|c{PDd:L3G+
HEK M1rEOWZ2dmO2aX;uJIF{e2G7 NUjiSHZjUEWNIHPlcIwh[WSqZYPpc44hdWWmaXH0[YQh[nliYXzwbIEhfiCkZYThJFMhcW62ZXfybY4tKEmFNUCgQUAxNjByMzFOwG0v MoLhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB4M{OwN|UoRjFyNkOzNFM2RC:jPh?=
In vivo In rat models of bone resorption and osteoporosis, SB273005 (30 mg/kg, p.o.) inhibits the parathyroid hormone-stimulated calcemic response, and inhibits bone loss. [1] In rat with adjuvant-induced arthritis, SB273005 (60 mg/kg, p.o.) significantly reduces the symptoms of adjuvant-induced arthritis. [2] SB273005 (1000 mg/kg/day, p.o.) causes acute, transient necrosis of vascular smooth muscle cell (VSMC) in aorta and renal arteries of mice. [4] In pregnant mice, SB273005 reverses the reduction of Th1 cell-produced IL-2 levels and the increase of Th2 cell-derived IL-10 levels. [5]

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Thyroidectomized−parathyroidectomized (TPTx) rat model of bone resorption, and ovariectomized (Ovx) rat model of osteoporosis
  • Dosages: 30 mg/kg
  • Administration: p.o.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 90 mg/mL warmed
(199.36 mM)
Ethanol 16 mg/mL warmed
(35.44 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 451.44
Formula

C22H24F3N3O4

CAS No. 205678-31-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CNC1=CC=CC(=N1)CCOC2=CC3=C(CC(C(=O)N(C3)CC(F)(F)F)CC(=O)O)C=C2

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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