For research use only.

Catalog No.S7540

14 publications

SB273005 Chemical Structure

CAS No. 205678-31-5

SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.

Selleck's SB273005 has been cited by 14 publications

1 Customer Review

  • Western blot analysis of levels of p-FAK (Tyr397) and total FAK in SK-N-SH cells treated with SB273005 (3 μM) for 6 h and 24 h. One experiment is shown for each cell line. Control cells (treated with diluent, marked as C, were also included). α-tubulin was used as the reference protein.

    Int J Oncol, 2017, 50(5):1899-1914. SB273005 purchased from Selleck.

Purity & Quality Control

Choose Selective Integrin Inhibitors

Biological Activity

Description SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
αvβ5 receptor [1]
(Cell-free assay)
αvβ3 receptor [1]
(Cell-free assay)
0.3 nM 1.2 nM
In vitro

In vitro, SB273005 inhibits human osteoclast-mediated bone resorption with IC50 of 11 nM. [1] In blood containing MDA-MB-231 cells, a combination of SB273005 and lamifiban inhibits tumor cell adhesion to vascular extracellular matrix (ECM). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK 293 cells NXzBdo5sTnWwY4Tpc44h[XO|YYm= NEDXUmNKdmirYnn0bY9vKG:oIG\peJJwdmWldHnuJJJm[2WydH;yMEBqdnSnZ4LpckBidHCqYW[tZoV1[TNiZYjwdoV{e2WmIHnuJGhGUyB{OUOgZ4VtdHNuIFnDOVA:OC5yMECxOUDPxE1? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjR5N{O0O{c,OTJ2N{ezOFc9N2F-
HEK MmfXSpVv[3Srb36gZZN{[Xl? NUf2bJlWUEWNIHPlcIwh[WSqZYPpc44hdWWmaXH0[YQh[nliYXzwbIEhfiCkZYThJFMhcW62ZXfybY4tKEmFNUCgQUAxNjByMzFOwG0v MkjpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB4M{OwN|UoRjFyNkOzNFM2RC:jPh?=

... Click to View More Cell Line Experimental Data

In vivo In rat models of bone resorption and osteoporosis, SB273005 (30 mg/kg, p.o.) inhibits the parathyroid hormone-stimulated calcemic response, and inhibits bone loss. [1] In rat with adjuvant-induced arthritis, SB273005 (60 mg/kg, p.o.) significantly reduces the symptoms of adjuvant-induced arthritis. [2] SB273005 (1000 mg/kg/day, p.o.) causes acute, transient necrosis of vascular smooth muscle cell (VSMC) in aorta and renal arteries of mice. [4] In pregnant mice, SB273005 reverses the reduction of Th1 cell-produced IL-2 levels and the increase of Th2 cell-derived IL-10 levels. [5]


Animal Research:[1]
- Collapse
  • Animal Models: Thyroidectomized−parathyroidectomized (TPTx) rat model of bone resorption, and ovariectomized (Ovx) rat model of osteoporosis
  • Dosages: 30 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 90 mg/mL warmed (199.36 mM)
Ethanol 16 mg/mL warmed (35.44 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 451.44


CAS No. 205678-31-5
Storage powder
in solvent
Synonyms N/A
Smiles CNC1=CC=CC(=N1)CCOC2=CC3=C(CC(C(=O)N(C3)CC(F)(F)F)CC(=O)O)C=C2

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Integrin Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID