SB273005

For research use only.

Catalog No.S7540

9 publications

SB273005 Chemical Structure

Molecular Weight(MW): 451.44

SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.

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Selleck's SB273005 has been cited by 9 publications

1 Customer Review

  • Western blot analysis of levels of p-FAK (Tyr397) and total FAK in SK-N-SH cells treated with SB273005 (3 μM) for 6 h and 24 h. One experiment is shown for each cell line. Control cells (treated with diluent, marked as C, were also included). α-tubulin was used as the reference protein.

    Int J Oncol, 2017, 50(5):1899-1914. SB273005 purchased from Selleck.

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Choose Selective Integrin Inhibitors

Biological Activity

Description SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
Targets
αvβ5 receptor [1]
(Cell-free assay)
αvβ3 receptor [1]
(Cell-free assay)
0.3 nM 1.2 nM
In vitro

In vitro, SB273005 inhibits human osteoclast-mediated bone resorption with IC50 of 11 nM. [1] In blood containing MDA-MB-231 cells, a combination of SB273005 and lamifiban inhibits tumor cell adhesion to vascular extracellular matrix (ECM). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK 293 cells NVXYUJlDTnWwY4Tpc44h[XO|YYm= MUHJcohq[mm2aX;uJI9nKF[rdILvcoVkfGmwIILlZ4VxfG:{LDDpcpRm\3KrbjDhcJBp[VZvYnX0ZVMh\XiycnXzd4VlKGmwIFjFT{AzQTNiY3XscJMtKEmFNUC9NE4xODBzNTFOwG0> MVixNlQ4PzN2Nx?=

... Click to View More Cell Line Experimental Data

In vivo In rat models of bone resorption and osteoporosis, SB273005 (30 mg/kg, p.o.) inhibits the parathyroid hormone-stimulated calcemic response, and inhibits bone loss. [1] In rat with adjuvant-induced arthritis, SB273005 (60 mg/kg, p.o.) significantly reduces the symptoms of adjuvant-induced arthritis. [2] SB273005 (1000 mg/kg/day, p.o.) causes acute, transient necrosis of vascular smooth muscle cell (VSMC) in aorta and renal arteries of mice. [4] In pregnant mice, SB273005 reverses the reduction of Th1 cell-produced IL-2 levels and the increase of Th2 cell-derived IL-10 levels. [5]

Protocol

Animal Research:[1]
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  • Animal Models: Thyroidectomized−parathyroidectomized (TPTx) rat model of bone resorption, and ovariectomized (Ovx) rat model of osteoporosis
  • Dosages: 30 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 90 mg/mL warmed (199.36 mM)
Ethanol 16 mg/mL warmed (35.44 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 451.44
Formula

C22H24F3N3O4

CAS No. 205678-31-5
Storage powder
in solvent
Synonyms N/A
Smiles CNC1=CC=CC(=N1)CCOC2=CC=C3CC(CC(O)=O)C(=O)N(CC3=C2)CC(F)(F)F

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Integrin Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID