Molecular Weight(MW): 451.44
SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
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Western blot analysis of levels of p-FAK (Tyr397) and total FAK in SK-N-SH cells treated with SB273005 (3 μM) for 6 h and 24 h. One experiment is shown for each cell line. Control cells (treated with diluent, marked as C, were also included). α-tubulin was used as the reference protein.
Int J Oncol, 2017, 50(5):1899-1914. SB273005 purchased from Selleck.
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Choose Selective Integrin Inhibitors
|Description||SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.|
In vitro, SB273005 inhibits human osteoclast-mediated bone resorption with IC50 of 11 nM.  In blood containing MDA-MB-231 cells, a combination of SB273005 and lamifiban inhibits tumor cell adhesion to vascular extracellular matrix (ECM). 
|In vivo||In rat models of bone resorption and osteoporosis, SB273005 (30 mg/kg, p.o.) inhibits the parathyroid hormone-stimulated calcemic response, and inhibits bone loss.  In rat with adjuvant-induced arthritis, SB273005 (60 mg/kg, p.o.) significantly reduces the symptoms of adjuvant-induced arthritis.  SB273005 (1000 mg/kg/day, p.o.) causes acute, transient necrosis of vascular smooth muscle cell (VSMC) in aorta and renal arteries of mice.  In pregnant mice, SB273005 reverses the reduction of Th1 cell-produced IL-2 levels and the increase of Th2 cell-derived IL-10 levels. |
-  Miller WH, et al. J Med Chem. 2000, 43(1), 22-26.
-  Badger AM, et al. Arthritis Rheum. 2001, 44(1), 128-137.
-  Gomes N, et al. Clin Exp Metastasis. 2004, 21(6), 553-561.
|In vitro||DMSO||90 mg/mL warmed (199.36 mM)|
|Ethanol||16 mg/mL warmed (35.44 mM)|
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