Catalog No.S7540

For research use only.

SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.

SB273005 Chemical Structure

CAS No. 205678-31-5

Selleck's SB273005 has been cited by 16 publications

Purity & Quality Control

Choose Selective Integrin Inhibitors

Biological Activity

Description SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
αvβ5 receptor [1]
(Cell-free assay)
αvβ3 receptor [1]
(Cell-free assay)
0.3 nM 1.2 nM
In vitro

In vitro, SB273005 inhibits human osteoclast-mediated bone resorption with IC50 of 11 nM. [1] In blood containing MDA-MB-231 cells, a combination of SB273005 and lamifiban inhibits tumor cell adhesion to vascular extracellular matrix (ECM). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK 293 cells M1XLR2Z2dmO2aX;uJIF{e2G7 Mlz5TY5pcWKrdHnvckBw\iCYaYTyc45m[3SrbjDy[YNmeHSxcjygbY51\We{aX6gZYxxcGGYLXLleIE{KGW6cILld5Nm\CCrbjDISWshOjl|IHPlcIx{NCCLQ{WwQVAvODByMUWg{txO MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjR5N{O0O{c,OTJ2N{ezOFc9N2F-
HEK MnHMSpVv[3Srb36gZZN{[Xl? Mn7VTGVMKGOnbHygZYRp\XOrb36gcYVlcWG2ZXSgZpkh[WyyaHGgekBj\XSjIEOgbY51\We{aX6sJGlEPTBiPTCwMlAxOyEQvF2u M{LZU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyNkOzNFM2Lz5zME[zN|A{PTxxYU6=
In vivo In rat models of bone resorption and osteoporosis, SB273005 (30 mg/kg, p.o.) inhibits the parathyroid hormone-stimulated calcemic response, and inhibits bone loss. [1] In rat with adjuvant-induced arthritis, SB273005 (60 mg/kg, p.o.) significantly reduces the symptoms of adjuvant-induced arthritis. [2] SB273005 (1000 mg/kg/day, p.o.) causes acute, transient necrosis of vascular smooth muscle cell (VSMC) in aorta and renal arteries of mice. [4] In pregnant mice, SB273005 reverses the reduction of Th1 cell-produced IL-2 levels and the increase of Th2 cell-derived IL-10 levels. [5]

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Thyroidectomized−parathyroidectomized (TPTx) rat model of bone resorption, and ovariectomized (Ovx) rat model of osteoporosis
  • Dosages: 30 mg/kg
  • Administration: p.o.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 451.44


CAS No. 205678-31-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CNC1=CC=CC(=N1)CCOC2=CC3=C(CC(C(=O)N(C3)CC(F)(F)F)CC(=O)O)C=C2

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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