Home Apoptosis Ferroptosis inhibitor SRS11-92 For research use only.

SRS11-92

Synonyms: AA9

SRS11-92 (AA9), a Ferrostatin-1 (Fer-1) analogue, is a potent inhibitor of ferroptosis. SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM.

SRS11-92 Chemical Structure

SRS11-92 Chemical Structure

CAS: 1467047-25-1

Selleck's SRS11-92 has been cited by 1 publication

Purity & Quality Control

Batch: S983901 DMSO] 70 mg/mL] false] Ethanol] 70 mg/mL] false] Water] Insoluble] false Purity: 99.19%
99.19

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Biological Activity

Description SRS11-92 (AA9), a Ferrostatin-1 (Fer-1) analogue, is a potent inhibitor of ferroptosis. SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM.
Targets
HT-1080 ferroptotic cell death [1]
(Cell-based assay)
6 nM(EC50)
In vitro
In vitro

SRS11-92 is efficacious in protecting human and mouse cellular models of FRDA treated with ferric ammonium citrate (FAC) and an inhibitor of glutathione synthesis (BSO). SRS11-92 decreases the cell death associated with frataxin knockdown in healthy human fibroblasts.[2]
Cell Research Cell lines murine I154F FRDA fibroblasts
Concentrations 50 μM to 500 nM
Incubation Time 48 h
Method

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Chemical Information & Solubility

Molecular Weight 352.47 Formula

C22H28N2O2
CAS No. 1467047-25-1 SDF --
Smiles CCOC(=O)C1=CC=C(NC2CCCCC2)C(=C1)NCC3=CC=CC=C3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 70 mg/mL ( (198.59 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 70 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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