Home Proteases MMP inhibitor - PI3K inhibitor - Akt inhibitor - MicroRNA inhibitor Solasodine

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Solasodine MMP inhibitor

Cat.No.S3309

Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. This compound reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). It downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. This chemical also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21.
Solasodine MMP inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 413.64

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Quality Control

Batch: S330901 DMSO]2 mg/mL]false]]]false]]]false Purity: 98.62%
98.62

Chemical Information, Storage & Stability

Molecular Weight 413.64 Formula

C27H43NO2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 126-17-0 -- Storage of Stock Solutions

Synonyms Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine Smiles CC1CCC2(NC1)OC3CC4C5CC=C6CC(O)CCC6(C)C5CCC4(C)C3C2C

Solubility

In vitro
Batch:

DMSO : 2 mg/mL (4.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Mechanism of Action

Targets/IC50/Ki
MMP-2 [1]
MMP-9 [1]
EMMPRIN [1]
RECK [1]
miR-21 [1]
References

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