Solasodine

Catalog No.S3309 Synonyms: Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine

For research use only.

Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). Solasodine downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21.

Solasodine Chemical Structure

CAS No. 126-17-0

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Biological Activity

Description Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). Solasodine downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21.
Targets
MMP-2 [1] MMP-9 [1] EMMPRIN [1] RECK [1] miR-21 [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 413.64
Formula

C27H43NO2

CAS No. 126-17-0
Storage 3 years -20°C powder
2 years -80°C in solvent

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