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Serotonin 5-HT Receptor agonist

Name: Serotonin
Brand: Selleck Chemicals
SKU: S6351
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S6351

Serotonin is a monoamine neurotransmitter in the Central Nervous System (CNS) and an endogenous 5-HT receptor agonist. This compound is also a catechol O-methyltransferase (COMT) inhibitor.

Serotonin 5-HT Receptor agonist Chemical Structure

Quality Control

Batch: Purity: 99.78%

99.78

Related Targets	Adrenergic Receptor AChR COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other 5-HT Receptor Inhibitors	Serotonin Hydrochloride (5-HT HCl) WAY-100635 Maleate Puerarin SB269970 HCl Ketanserin BRL-15572 Dihydrochloride Nuciferine RS-127445 Flopropione Azacyclonol

Solubility

In vitro
Batch:

DMSO : 43 mg/mL (244.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	176.22	Formula	C₁₀H₁₂N₂O	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	50-67-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-07-21)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07716982	NOT_YET_RECRUITING	Depression Disorder	Hôpital le Vinatier	2026-09
NCT07189299	NOT_YET_RECRUITING	PMS; PMDD	Friederike Holze	2025-10-01
NCT06704594	RECRUITING	Premenstrual Dysphoric Disorder (PMDD)	Johns Hopkins University	2025-05-14	PHASE4
NCT07390981	NOT_YET_RECRUITING	Major Depressive Disorder	First People's Hospital of Hangzhou	2026-03-01
NCT07651293	NOT_YET_RECRUITING	Depression - Major Depressive Disorder	Imperial College Healthcare NHS Trust	2026-07-01
NCT06592833	RECRUITING	Major Depressive Disorder	Icahn School of Medicine at Mount Sinai	2025-02-25	PHASE2

Tech Support

Handling Instructions

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