Home Metabolism LDH inhibitor Sodium oxamate

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Sodium oxamate LDH inhibitor

Cat.No.S6871

Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. This compound induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.
Sodium oxamate LDH inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 111.03

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Quality Control

Batch: Purity: 98.03%
98.03

Cell Culture, Treatment & Working Concentration

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
insect cells Function assay 10 mins Inhibition of human recombinant carboxy-terminal his-tagged LDHB (1 to 333) expressed in insect cells using pyruvate as substrate after 10 mins by UV endpoint analysis, IC50=33.8μM 23628333
Click to View More Cell Line Experimental Data

Solubility

In vitro
Batch:

Water : 22 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 111.03 Formula

C2H2NNaO3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 565-73-1 -- Storage of Stock Solutions

Synonyms SO, oxamate sodium, Aminooxoacetic acid sodium salt, Oxamic acid sodium salt Smiles C(=O)(C(=O)[O-])N.[Na+]

Mechanism of Action

Targets/IC50/Ki
LDHA
ROS
CDK1
In vitro

Sodium oxamate, a specific inhibitor of LDH-A, enhances the suppressive effects of PARP inhibitors on ovarian cancer without BRCA mutations, remarkably promoting the inhibitory effects of PARP inhibitors on wild-type BRCA ovarian cancer cells.
In vivo

Sodium oxamate reduces the growth of colorectal cancer in CRC mice, by restoring the down-regulated MMR functional proteins.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/34345205/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03883360 Withdrawn
Schizophrenia Spectrum Disorders|Cannabis Use
University of Maryland Baltimore|Sheppard Pratt Health System|University of California Los Angeles
 January 2050 Phase 2
NCT03643367 Not yet recruiting
Shock Septic
University of Zurich|Kantonsspital Münsterlingen|Triemli Hospital|Waid City Hospital Zurich
 January 2025 Phase 2
NCT05657925 Not yet recruiting
Sleep Syncope
University of Calgary
 December 1 2024 Phase 3
NCT05771922 Recruiting
Ultrasound Therapy; Complications Anomaly Central Nervous System Diseases
Woman''s Health University Hospital Egypt
 November 30 2024 --
NCT05854212 Not yet recruiting
Food Insecurity|Dietary Quality|Behavioral Economics|Implementation Science
Massachusetts General Hospital
 November 2024 Not Applicable

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