Sodium oxamate

Catalog No.S6871 Synonyms: SO, oxamate sodium, Aminooxoacetic acid sodium salt, Oxamic acid sodium salt

For research use only.

Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.

Sodium oxamate Chemical Structure

CAS No. 565-73-1

Selleck's Sodium oxamate has been cited by 2 Publications

Purity & Quality Control

Choose Selective LDH Inhibitors

Biological Activity

Description Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.
Targets
LDHA [1] ROS [2] CDK1 [2]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
insect cells NVTHbVFqTnWwY4Tpc44h[XO|YYm= M2fEfFExKG2rboO= MXPJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KGOjcnLvfJkufGW{bXnuZYwhcGm|LYTh[4dm\CCORFjCJEgyKHSxIEOzN{kh\XiycnXzd4VlKGmwIHnud4VkfCClZXzsd{B2e2mwZzDwfZJ2fmG2ZTDhd{B{fWK|dILheIUh[W[2ZYKgNVAhdWmwczDifUBWXiCnbnTwc4lvfCCjbnHsfZNqeyxiSVO1NF0{Oy56zszN M1jQTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkK4N|M{Lz5{M{[yPFM{OzxxYU6=

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 111.03
Formula

C2H2NNaO3

CAS No. 565-73-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(=O)(C(=O)[O-])N.[Na+]

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03883360 Withdrawn Drug: Cannabidiol (CBD)|Drug: Placebo Schizophrenia Spectrum Disorders|Cannabis Use University of Maryland Baltimore|Sheppard Pratt Health System|University of California Los Angeles January 2050 Phase 2
NCT03643367 Not yet recruiting Drug: Sevoflurane|Drug: Control Group Shock Septic University of Zurich|Kantonsspital Münsterlingen|Triemli Hospital|Waid City Hospital Zurich January 2025 Phase 2
NCT04571502 Not yet recruiting Other: CareHeroes Neurocognitive Disorders|Alzheimer Disease|Caregiver Florida International University|National Institute on Aging (NIA)|University of Alabama Tuscaloosa September 2023 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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