Sodium ascorbate

For research use only.

Catalog No.S4245

2 publications

Sodium ascorbate Chemical Structure

Molecular Weight(MW): 198.11

Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.

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Biological Activity

Description Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
In vitro

Sodium ascorbate has a growth inhibiting action only at high concentrations in cultured human neoplastic cell lines MCF-7 (breast carcinoma), KB (oral epidermoid carcinoma), and AN3-CA (endometrial adenocarcinoma). Sodium ascorbate combined with vitamin K3 demonstrates a synergistic inhibition of cell growth at 10 to 50 times lower concentrations in cultured human neoplastic cell lines MCF-7, KB, and AN3-CA, at this level separately given vitamins are not toxic. This tumor cell growth inhibitory effect is completely suppressed by the addition of catalase to the culture medium containing vitamins C and K3, suggesting an excessive production of hydrogen peroxide as being implied in mechanisms responsible for the above-mentioned effects. [1] Sodium ascorbate combined with vitamin K3 results in a synergistic effect on growth inhibition in cultured human endometrial adenocarcinoma (AN3CA) cells. [2] Sodium ascorbate results in a rapid increase in the intracellular concentration of Ca2+ ions and subsequent apoptotic cell death in HL-60 cells, characterized by cell shrinkage, nuclear fragmentation and cleavage of internucleosomal DNA to yield fragments that are multiples of 180-200 base pairs, are induced. [3] Sodium ascorbate (100 μM) induces DNA single-strand breaks in human cells, Fibroblasts and Molt-4 cells are significantly more sensitive than lymphocytes. Sodium ascorbate (50 μM) results in significant cell loss in Molt-4 cells, but not in lymphocyte and fibroblast cultures. [4]

Protocol

Solubility (25°C)

In vitro Water 40 mg/mL (201.9 mM)
DMSO 2 mg/mL (10.09 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 198.11
Formula

C6H7NaO6

CAS No. 134-03-2
Storage powder
in solvent
Synonyms N/A
Smiles [NaH].OCC(O)C1OC(=O)C(O)C1O

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03123107 Active not recruiting Drug: Ascorbic Acid Coronary Artery Bypass Graft Surgery Geisinger Clinic|Wilkes University July 6 2017 Phase 1
NCT02342405 Completed Other: 80% oxygen|Other: 30% oxygen Endothelial Dysfunction Zealand University Hospital January 2015 Not Applicable
NCT02106975 Completed Drug: Ascorbic Acid|Drug: Placebo: 5% Dextrose in water Acute Lung Injury|Sepsis Virginia Commonwealth University|National Heart Lung and Blood Institute (NHLBI) April 2014 Phase 2
NCT01714466 Completed Drug: NER1006|Drug: MOVIPREP Colon Cancer Norgine October 2012 Phase 2
NCT01515046 Terminated Drug: Gemcitabine with escalating ascorbic acid Pancreatic Neoplasms|Pancreatic Cancer Joseph J. Cullen|Susan L Bader Foundation of Hope|Holden Comprehensive Cancer Center|National Cancer Institute (NCI)|University of Iowa September 2012 Phase 2
NCT01364805 Completed Drug: Intravenous Vitamin C|Drug: Gemcitabine Pancreatic Cancer Jeanne Drisko MD CNS FACN|Lotte & John Hecht Memorial Foundation|University of Kansas Medical Center April 2011 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID