Home Metabolism Vitamin chemical Sodium ascorbate

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Sodium ascorbate Vitamin chemical

Cat.No.S4245

Sodium Ascorbate (Sodium Vitamin C) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
Sodium ascorbate Vitamin chemical Chemical Structure

Chemical Structure

Molecular Weight: 198.11

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Quality Control

Batch: S424501 Water]40 mg/mL]false]DMSO]2 mg/mL]false]Ethanol]Insoluble]false Purity: 99.81%
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  • COA
  • NMR
  • HPLC
  • SDS
  • Datasheet
99.81

Solubility

In vitro
Batch:

Water : 40 mg/mL

DMSO : 2 mg/mL (10.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 198.11 Formula

C6H7NaO6

 Storage (From the date of receipt)
CAS No. 134-03-2 Download SDF Storage of Stock Solutions

Synonyms Sodium Vitamin C Smiles C(C(C1C(=C(C(=O)O1)O)[O-])O)O.[Na+]

Mechanism of Action

In vitro
Sodium ascorbate has a growth inhibiting action only at high concentrations in cultured human neoplastic cell lines MCF-7 (breast carcinoma), KB (oral epidermoid carcinoma), and AN3-CA (endometrial adenocarcinoma). This compound combined with vitamin K3 demonstrates a synergistic inhibition of cell growth at 10 to 50 times lower concentrations in cultured human neoplastic cell lines MCF-7, KB, and AN3-CA, at this level separately given vitamins are not toxic. This tumor cell growth inhibitory effect is completely suppressed by the addition of catalase to the culture medium containing vitamins C and K3, suggesting an excessive production of hydrogen peroxide as being implied in mechanisms responsible for the above-mentioned effects. This chemical combined with vitamin K3 results in a synergistic effect on growth inhibition in cultured human endometrial adenocarcinoma (AN3CA) cells. It results in a rapid increase in the intracellular concentration of Ca2+ ions and subsequent apoptotic cell death in HL-60 cells, characterized by cell shrinkage, nuclear fragmentation and cleavage of internucleosomal DNA to yield fragments that are multiples of 180-200 base pairs, are induced. This compound (100 μM) induces DNA single-strand breaks in human cells, Fibroblasts and Molt-4 cells are significantly more sensitive than lymphocytes. It (50 μM) results in significant cell loss in Molt-4 cells, but not in lymphocyte and fibroblast cultures.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/9202729/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05842382 Not yet recruiting
Pneumonia
Clinical Research Centre Malaysia|Ain Medicare Sdn Bhd
 December 2023 Phase 2
NCT04634227 Recruiting
Sarcoma|Soft Tissue Sarcoma|Unresectable Soft Tissue Sarcoma|Metastatic Bone Tumor|Bone Sarcoma
Mohammed Milhem MBBS|University of Iowa
 November 24 2020 Early Phase 1
NCT03508726 Active not recruiting
Soft Tissue Sarcoma
Mohammed Milhem|University of Iowa
 June 27 2019 Phase 1|Phase 2
NCT02107976 Recruiting
Diabetes Type 2
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC)
 June 14 2019 Phase 1
NCT03123107 Completed
Coronary Artery Bypass Graft Surgery
Geisinger Clinic|Wilkes University
 July 6 2017 Phase 1
NCT02460783 Completed
Alzheimer''s Disease|Obesity|Diabetes Mellitus
National Institute on Aging (NIA)|National Institutes of Health Clinical Center (CC)
 June 22 2015 Not Applicable

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