For research use only.
CAS No. 134-03-2
Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
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|Description||Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.|
Sodium ascorbate has a growth inhibiting action only at high concentrations in cultured human neoplastic cell lines MCF-7 (breast carcinoma), KB (oral epidermoid carcinoma), and AN3-CA (endometrial adenocarcinoma). Sodium ascorbate combined with vitamin K3 demonstrates a synergistic inhibition of cell growth at 10 to 50 times lower concentrations in cultured human neoplastic cell lines MCF-7, KB, and AN3-CA, at this level separately given vitamins are not toxic. This tumor cell growth inhibitory effect is completely suppressed by the addition of catalase to the culture medium containing vitamins C and K3, suggesting an excessive production of hydrogen peroxide as being implied in mechanisms responsible for the above-mentioned effects.  Sodium ascorbate combined with vitamin K3 results in a synergistic effect on growth inhibition in cultured human endometrial adenocarcinoma (AN3CA) cells.  Sodium ascorbate results in a rapid increase in the intracellular concentration of Ca2+ ions and subsequent apoptotic cell death in HL-60 cells, characterized by cell shrinkage, nuclear fragmentation and cleavage of internucleosomal DNA to yield fragments that are multiples of 180-200 base pairs, are induced.  Sodium ascorbate (100 μM) induces DNA single-strand breaks in human cells, Fibroblasts and Molt-4 cells are significantly more sensitive than lymphocytes. Sodium ascorbate (50 μM) results in significant cell loss in Molt-4 cells, but not in lymphocyte and fibroblast cultures. 
|In vitro||Water||40 mg/mL (201.9 mM)|
|DMSO||2 mg/mL (10.09 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04634227||Recruiting||Drug: Ascorbate||Sarcoma|Soft Tissue Sarcoma|Unresectable Soft Tissue Sarcoma|Metastatic Bone Tumor|Bone Sarcoma||Varun Monga MD|University of Iowa Adolescent and Young Adult (AYA) Cancer Program|St. Baldrick''s Foundation|University of Iowa||November 24 2020||Early Phase 1|
|NCT03123107||Active not recruiting||Drug: Ascorbic Acid||Coronary Artery Bypass Graft Surgery||Geisinger Clinic|Wilkes University||July 6 2017||Phase 1|
|NCT02342405||Completed||Other: 80% oxygen|Other: 30% oxygen||Endothelial Dysfunction||Zealand University Hospital||January 2015||Not Applicable|
|NCT02106975||Completed||Drug: Ascorbic Acid|Drug: Placebo: 5% Dextrose in water||Acute Lung Injury|Sepsis||Virginia Commonwealth University|National Heart Lung and Blood Institute (NHLBI)||April 2014||Phase 2|
|NCT01714466||Completed||Drug: NER1006|Drug: MOVIPREP||Colon Cancer||Norgine||October 2012||Phase 2|
|NCT01515046||Terminated||Drug: Gemcitabine with escalating ascorbic acid||Pancreatic Neoplasms|Pancreatic Cancer||Joseph J. Cullen|Susan L Bader Foundation of Hope|Holden Comprehensive Cancer Center|National Cancer Institute (NCI)|University of Iowa||September 2012||Phase 2|
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