Sodium ascorbate

For research use only.

Catalog No.S4245

2 publications

Sodium ascorbate Chemical Structure

CAS No. 134-03-2

Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.

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Selleck's Sodium ascorbate has been cited by 2 publications

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Biological Activity

Description Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
In vitro

Sodium ascorbate has a growth inhibiting action only at high concentrations in cultured human neoplastic cell lines MCF-7 (breast carcinoma), KB (oral epidermoid carcinoma), and AN3-CA (endometrial adenocarcinoma). Sodium ascorbate combined with vitamin K3 demonstrates a synergistic inhibition of cell growth at 10 to 50 times lower concentrations in cultured human neoplastic cell lines MCF-7, KB, and AN3-CA, at this level separately given vitamins are not toxic. This tumor cell growth inhibitory effect is completely suppressed by the addition of catalase to the culture medium containing vitamins C and K3, suggesting an excessive production of hydrogen peroxide as being implied in mechanisms responsible for the above-mentioned effects. [1] Sodium ascorbate combined with vitamin K3 results in a synergistic effect on growth inhibition in cultured human endometrial adenocarcinoma (AN3CA) cells. [2] Sodium ascorbate results in a rapid increase in the intracellular concentration of Ca2+ ions and subsequent apoptotic cell death in HL-60 cells, characterized by cell shrinkage, nuclear fragmentation and cleavage of internucleosomal DNA to yield fragments that are multiples of 180-200 base pairs, are induced. [3] Sodium ascorbate (100 μM) induces DNA single-strand breaks in human cells, Fibroblasts and Molt-4 cells are significantly more sensitive than lymphocytes. Sodium ascorbate (50 μM) results in significant cell loss in Molt-4 cells, but not in lymphocyte and fibroblast cultures. [4]


Solubility (25°C)

In vitro Water 40 mg/mL (201.9 mM)
DMSO 2 mg/mL (10.09 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 198.11


CAS No. 134-03-2
Storage powder
in solvent
Synonyms N/A
Smiles C(C(C1C(=C(C(=O)O1)O)[O-])O)O.[Na+]

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04634227 Recruiting Drug: Ascorbate Sarcoma|Soft Tissue Sarcoma|Unresectable Soft Tissue Sarcoma|Metastatic Bone Tumor|Bone Sarcoma Varun Monga MD|University of Iowa Adolescent and Young Adult (AYA) Cancer Program|St. Baldrick''s Foundation|University of Iowa November 24 2020 Early Phase 1
NCT03123107 Active not recruiting Drug: Ascorbic Acid Coronary Artery Bypass Graft Surgery Geisinger Clinic|Wilkes University July 6 2017 Phase 1
NCT02342405 Completed Other: 80% oxygen|Other: 30% oxygen Endothelial Dysfunction Zealand University Hospital January 2015 Not Applicable
NCT02106975 Completed Drug: Ascorbic Acid|Drug: Placebo: 5% Dextrose in water Acute Lung Injury|Sepsis Virginia Commonwealth University|National Heart Lung and Blood Institute (NHLBI) April 2014 Phase 2
NCT01714466 Completed Drug: NER1006|Drug: MOVIPREP Colon Cancer Norgine October 2012 Phase 2
NCT01515046 Terminated Drug: Gemcitabine with escalating ascorbic acid Pancreatic Neoplasms|Pancreatic Cancer Joseph J. Cullen|Susan L Bader Foundation of Hope|Holden Comprehensive Cancer Center|National Cancer Institute (NCI)|University of Iowa September 2012 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID