Sunitinib

For research use only.

Catalog No.S7781 Synonyms: SU11248

155 publications

CAS No. 557795-19-4

Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.

Selleck's Sunitinib has been cited by 155 publications

Nature, 2011, 12;478(7369):349-55.

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Blood Cancer J, 2021, 11(3):57

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Cancers (Basel), 2021, 13(2)E361

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Drug Metab Dispos, 2021, 49(1):53-61

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Mol Med Rep, 2021, 23(1)40

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Cancers (Basel), 2021, 13(4)653

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Cell Death Dis, 2021, 12(2):220

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Eur J Pharmacol, 2021, 895:173868

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Clin Cancer Res, 2020, 20 pii: clincanres

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Cancer Res, 2020, canres.1992.2020

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Nanoscale, 2020, 12(5):3400-3410

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Cancers (Basel), 2020, 12(9)E2586

PubMed: 32927828 ( click the link to review the publication )

Cancers (Basel), 2020, 12(12)E3816

PubMed: 33348809 ( click the link to review the publication )

Cancers (Basel), 2020, 27;12(5)pii: E1087

PubMed: 32349331 ( click the link to review the publication )

Cancers (Basel), 2020, 13;12(2) pii: E436

PubMed: 32069833 ( click the link to review the publication )

Cancers (Basel), 2020, 17;12(1):232

PubMed: 31963500 ( click the link to review the publication )

Breast Cancer Res, 2020, 22(1):103

PubMed: 32993785 ( click the link to review the publication )

Cell Death Dis, 2020, 7;11(5):337

PubMed: 32382017 ( click the link to review the publication )

Br J Cancer, 2020, 10.1038/s41416-020-0952-1

PubMed: 32572172 ( click the link to review the publication )

Neuroendocrinology, 2020, 3

PubMed: 32241015 ( click the link to review the publication )

Hum Mol Genet, 2020, ddaa268

PubMed: 33326033 ( click the link to review the publication )

Front Oncol, 2020, 12;10:696

PubMed: 32528877 ( click the link to review the publication )

Cancer Cell Int, 2020, 19;20:58

PubMed: 32099531 ( click the link to review the publication )

Skelet Muscle, 2020, 10(1):28

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Int J Parasitol Drugs Drug Resist, 2020, 14:167-182

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PLoS One, 2020, 15(8):e0232917

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DNA Cell Biol, 2020, 39(4):654-660

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Thorac Cancer, 2020, 5

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Hum Cell, 2020, 10.1007/s13577-020-00420-z

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Hum Cell, 2020, 10.1007/s13577-020-00425-8

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Int J Oncol, 2020, 56(1):113-122

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J Immunother, 2020, 43(1):16-28

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Biochem Biophys Res Commun, 2020, 529(3):699-706

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Nat Cell Biol, 2019, 10.1038/s41556-019-0415-1

PubMed: 31740775 ( click the link to review the publication )

Theranostics, 2019, 9(21):6175-6190

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Theranostics, 2019, 9(18):5332-5346

PubMed: 31410218 ( click the link to review the publication )

Theranostics, 2019, 9(3):661-675

PubMed: 30809300 ( click the link to review the publication )

EBioMedicine, 2019, 39:255-264

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J Med Chem, 2019, 10.1021/acs.jmedchem.9b01229

PubMed: 31721578 ( click the link to review the publication )

J Med Chem, 2019, 62(3):1274-1290

PubMed: 30633509 ( click the link to review the publication )

Cancers (Basel), 2019, 11(4)

PubMed: 31013908 ( click the link to review the publication )

Mol Cancer Ther, 2019, 18(11):1985-1996

PubMed: 31308077 ( click the link to review the publication )

Hum Mol Genet, 2019, 10.1093/hmg/ddz152

PubMed: 31518391 ( click the link to review the publication )

Biochem Pharmacol, 2019, 164:94-105

PubMed: 30953637 ( click the link to review the publication )

Sci Rep, 2019, 9(1):14636

PubMed: 31601958 ( click the link to review the publication )

Sci Rep, 2019, 9(1):6004

PubMed: 30979919 ( click the link to review the publication )

Endocrinology, 2019, 160(11):2600-2617

PubMed: 31322702 ( click the link to review the publication )

Front Endocrinol (Lausanne), 2019, 10:682

PubMed: 31636608 ( click the link to review the publication )
Cell Biosci, 2019, 9:88

PubMed: 31673329 ( click the link to review the publication )

Molecules, 2019, 24(3)

PubMed: 30754629 ( click the link to review the publication )

Oncol Rep, 2019, 42(5):1924-1934

PubMed: 31545458 ( click the link to review the publication )

Oncol Rep, 2019, 42(5):2039-2048

PubMed: 31485624 ( click the link to review the publication )

Neuromolecular Med, 2019, 21(4):414-431

PubMed: 30911877 ( click the link to review the publication )

Cancer Chemother Pharmacol, 2019, 10.1007/s00280-019-03985-1

PubMed: 31691077 ( click the link to review the publication )

PLoS One, 2019, 14(4):e0213942

PubMed: 30939138 ( click the link to review the publication )

Leuk Res, 2019, 78:12-20

PubMed: 30660961 ( click the link to review the publication )

Pharm Biol, 2019, 57(1):625-631

PubMed: 31545912 ( click the link to review the publication )

Endocr Connect, 2019, 8(6):680-690

PubMed: 31035254 ( click the link to review the publication )

Oncotarget, 2019, 10(53):5534-5548

PubMed: 31565187 ( click the link to review the publication )

Nat Biomed Eng, 2018, 2(8):578-588

PubMed: 31015631 ( click the link to review the publication )

Nat Commun, 2018, 9(1):4583

PubMed: 30389923 ( click the link to review the publication )

Autophagy, 2018, 14(12):2155-2170

PubMed: 30205729 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(14):3465-3474

PubMed: 29615457 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(1):169-180

PubMed: 29084916 ( click the link to review the publication )

Cancer Res, 2018, 78(16):4704-4715

PubMed: 29895675 ( click the link to review the publication )

EBioMedicine, 2018, 27:225-236

PubMed: 29289530 ( click the link to review the publication )

Cancer Lett, 2018, 420:49-59

PubMed: 29409989 ( click the link to review the publication )

Cancers (Basel), 2018, 10(10)E365

PubMed: 30274248 ( click the link to review the publication )

Pigment Cell Melanoma Res, 2018, 31(2):253-266

PubMed: 28972303 ( click the link to review the publication )

J Cereb Blood Flow Metab, 2018, 38(1):45-57

PubMed: 28741407 ( click the link to review the publication )

Endocr Relat Cancer, 2018, 25(4):471-480

PubMed: 29440231 ( click the link to review the publication )

Nanomedicine, 2018,

PubMed: 29626524 ( click the link to review the publication )
Cancer Sci, 2018, 109(4):1207-1219

PubMed: 29446853 ( click the link to review the publication )

Cancer Sci, 2018, 109(11):3591-3601

PubMed: 30142229 ( click the link to review the publication )

Antiviral Res, 2018, 155:67-75

PubMed: 29753658 ( click the link to review the publication )

Int J Oncol, 2018, 52(4):1350-1362

PubMed: 29532881 ( click the link to review the publication )

J Pharm Biomed Anal, 2018, 150:112-120

PubMed: 29220734 ( click the link to review the publication )

Oncotarget, 2018, 9(4):4661-4674

PubMed: 29435133 ( click the link to review the publication )

Oncotarget, 2018, 9(100):37352-37366

PubMed: 30647837 ( click the link to review the publication )

Oncotarget, 2018,

PubMed: 30038711 ( click the link to review the publication )

Oncotarget, 2018, 9(89):35962-35973

PubMed: 30542510 ( click the link to review the publication )

Sci Transl Med, 2017, 14;9(394):eaah6144

PubMed: 28615362 ( click the link to review the publication )

Nat Commun, 2017, 8;8:15617

PubMed: 28593995 ( click the link to review the publication )

Nat Commun, 2017, 1;8(1):1232

PubMed: 29089541 ( click the link to review the publication )

Cancer Res, 2017, 77(4):1008-1020

PubMed: 28011623 ( click the link to review the publication )

Cancer Res, 2017, 77(9):2512-2521

PubMed: 28202514 ( click the link to review the publication )

J Control Release, 2017, 245:81-94

PubMed: 27863995 ( click the link to review the publication )

Oncogene, 2017, 36(48):6691-6700

PubMed: 28745317 ( click the link to review the publication )

Arch Toxicol, 2017, 91(8):2921-2938

PubMed: 28032146 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(10-:2130-2143

PubMed: 28751539 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2017, 329:282-292

PubMed: 28624441 ( click the link to review the publication )

BMC Cancer, 2017,

PubMed: 28806950 ( click the link to review the publication )

J Appl Toxicol, 2017, 37(3):382-390

PubMed: 27480533 ( click the link to review the publication )

Oncotarget, 2017, 8(23):37250-37262

PubMed: 28422745 ( click the link to review the publication )

J Extracell Vesicles, 2017, 6(1):1359479

PubMed: 28815003 ( click the link to review the publication )

Leuk Res, 2017, 61:44-52

PubMed: 28888102 ( click the link to review the publication )
Oncotarget, 2017, 9(4):5111-5124

PubMed: 29435166 ( click the link to review the publication )

Genome Biol, 2016, 17:80

PubMed: 27139883 ( click the link to review the publication )

Nat Commun, 2016, 7:11363

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J Clin Invest, 2016, 3;126(10):3739-3757

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Clin Cancer Res, 2016, 22(23):5839-5850

PubMed: 27220962 ( click the link to review the publication )

Cancer Res, 2016, 76(5):1181-92

PubMed: 26645560 ( click the link to review the publication )

Elife, 2016, 5e11405

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Mol Oncol, 2016, 10(1):101-12

PubMed: 26471831 ( click the link to review the publication )

Toxicol Sci, 2016, 149(1):4-14

PubMed: 26385865 ( click the link to review the publication )

Int J Endocrinol, 2016, 2016:5286972

PubMed: 27990160 ( click the link to review the publication )

Clin Transl Immunology, 2016, 5(12):e119

PubMed: 28090321 ( click the link to review the publication )

Mol Cells, 2016, 39(12):898-908

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Oncotarget, 2016, 7(30):47465-47478

PubMed: 27329844 ( click the link to review the publication )

Oncotarget, 2016, 7(18-:25983-6002

PubMed: 27036020 ( click the link to review the publication )

Sci Transl Med, 2015, 7(284):284ra57

PubMed: 25904741 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2015, 112(6):1839-44

PubMed: 25605917 ( click the link to review the publication )

Mol Syst Biol, 2015, 11(1):789

PubMed: 25699542 ( click the link to review the publication )

Mol Cancer Ther, 2015, 14(10-:2238-48

PubMed: 26208525 ( click the link to review the publication )

Exp Cell Res, 2015, 332(1):1-10

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Pulm Pharmacol Ther, 2015, 10.1016/j.pupt.2015.03.001

PubMed: 25843005 ( click the link to review the publication )

Oncotarget, 2015, 6(29):27227-38

PubMed: 26317900 ( click the link to review the publication )

Clin Cancer Res, 2014, 20(22):5745-5755

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Clin Cancer Res, 2014, 20(9):2410-23

PubMed: 24573550 ( click the link to review the publication )

Clin Cancer Res, 2014, 20(11):2898-909

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Leukemia, 2014, 28(11):2197-205

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Proc Natl Acad Sci USA, 2014, 111(14):5319-24

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Ann Surg, 2014, 259(4):793-9

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Elife, 2014, 3:e02523

PubMed: 24844246 ( click the link to review the publication )

Oncogene, 2014, 33(19):2531-9

PubMed: 23728343 ( click the link to review the publication )

Br J Pharmacol, 2014, 171(24):5728-42

PubMed: 25091695 ( click the link to review the publication )

Br J Pharmacol, 2014, 171(24):5757-73

PubMed: 25117211 ( click the link to review the publication )

J Clin Endocrinol Metab, 2014, 99(2):498-509

PubMed: 24276455 ( click the link to review the publication )

Cancer Cell Int, 2014, 0.645138888888889

PubMed: ( click the link to review the publication )

Drug Metab Dispos, 2014, 42(11):1851-7

PubMed: 25165131 ( click the link to review the publication )

Transl Oncol, 2014, 19(9):2368-80

PubMed: 23633458 ( click the link to review the publication )

PLoS One, 2014, 9(1):e85759

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Fitoterapia, 2014, 92:34-40

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Korean J Parasitol, 2014, 52(4):439-41

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Cytometry A, 2014, 85(6):537-47

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Oncotarget, 2014, 5(16):6801-15

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Oncotarget, 2014, 5(7):1926-41

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Cancer Lett, 2013, 340(1):43-50

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Pigment Cell Melanoma Res, 2013, 26(4):518-26

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Br J Cancer, 2013, 109(3):686-93

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Apoptosis, 2013, 19(4):682-97

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Mol Cell Endocrinol, 2013, 377(1-2):1-6

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Proteomics, 2013, 13(23-24):3554-62

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Acta Oncol, 2013, 53(5):637-45

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Transl Oncol, 2013, 6(2):187-96

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Am J Nucl Med Mol Imaging, 2013, 3(5):397-407

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SENSOR ACTUAT B-CHEM, 2012, Jin Akagi

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Surgery, 2012, 152(6):1142-9

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Surgery, 2012, 152(6):1045-50

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J Biomol Screen, 2012, 17(6):813-21

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J Biomol Screen, 2012, 18(4):388-99

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Cell Res, 2011, 21(7):1080-7

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Mol Cancer Ther, 2011, 10(10):1897-908

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Blood, 2010, 115(23):4725-33

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Biochem Bioph Res Co, 2010, 398(2):205-11

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Purity & Quality Control

Choose Selective PDGFR Inhibitors

Biological Activity

Description

Targets

FLT3 ^[1] (Cell-free assay)	c-Kit ^[1] (Cell-free assay)	PDGFRβ ^[1] (Cell-free assay)	VEGFR2 ^[1] (Cell-free assay)
		2 nM	80 nM

In vitro

Sunitinib also potently inhibits Kit and FLT-3. ^[1] Sunitinib is a potent ATP-competitive inhibitor of VEGFR2 (Flk1) and PDGFRβ with K_i of 9 nM and 8 nM, respectively, displaying >10-fold higher selectivity for VEGFR2 and PDGFR than FGFR-1, EGFR, Cdk2, Met, IGFR-1, Abl, and src. In serum-starved NIH-3T3 cells expressing VEGFR2 or PDGFRβ, Sunitinib inhibits VEGF-dependent VEGFR2 phosphorylation and PDGF-dependent PDGFRβ phosphorylation with IC50 of 10 nM and 10 nM, respectively. Sunitinib inhibits VEGF-induced proliferation of serum-starved HUVECs with IC50 of 40 nM, and inhibits PDGF-induced proliferation of NIH-3T3 cells overexpressing PDGFRβ or PDGFRα with IC50 of 39 nM and 69 nM, respectively. ^[2] Sunitinib inhibits phosphorylation of wild-type FLT3, FLT3-ITD, and FLT3-Asp835 with IC50 of 250 nM, 50 nM, and 30 nM, respectively. Sunitinib inhibits the proliferation of MV4;11 and OC1-AML5 cells with IC50 of 8 nM and 14 nM, respectively, and induces apoptosis in a dose-dependent manner. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
HUVEC cell	Ml61SpVv[3Srb36gZZN{[Xl?		MWGyOEBp	MX7Jcohq[mm2aX;uJI9nKF[HR1[tRUBqdmS3Y3XkJGhWXkWFIHPlcIwhe3C{b4X0bY5oKGGodHXyJFI1KGi{czDifUBidmerb3flcoV{cXNiYYPzZZktKEmFNUC9NE4yOiEQvF2=	NF:0ZWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUe0NVI1QSd-MkG3OFEzPDl:L3G+
HEK293	NFGxc3VHfW6ldHnvckBie3OjeR?=			NVjV[GdYSmmwZHnu[{Bi\m[rbnn0fUB1dyCITGSzJINifGGueYTpZ{Bld22jaX6g[ZhxemW\|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBkd22yZYTpeIl3\SCkaX7kbY5oKGG\|c3H5MEBM\CB;IECuNFAxPDdizszNMi=>	NFnPfoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe1OFE6QSd-MUm3OVQyQTl:L3G+
MV4-11	M1vlNWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MVy3NkBpenN?	MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IF\MWFMuUVSGIHTldIVv\GWwdDDoeY1idiCPVkStNVEh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCwMlAxOSEQvF2u	NV;2W2FmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
HL60	MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NVPZfHpPPzJiaILz	M2XvTWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNFAyKM7:TT6=	NGLyOY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BAF3	M3;WcmZ2dmO2aX;uJIF{e2G7		M{fn[FczKGi{cx?=	MVzJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJHQ3PzCLIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUCgQUAxNjByMjFOwG0v	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
MV4-11	NVn4[XJ{S3m2b4TvfIlkcXS7IHHzd4F6		NGP0[3k4OiCqcoO=	NITneG1EgXSxdH;4bYNqfHliYXfhbY5{fCCITGSzMYRmeGWwZHXueEBpfW2jbjDNWlQuOTFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODB\|IN88UU4>	NV7WOZhJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OVI2OThpPkKyOFUzPTF6PD;hQi=>
MV411	NXO4[\|BHSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MY[0PEBpenN?	MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2YNEGxJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkCwN{DPxE1w	NVK3UIkzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFQ6PjFpPkK0PVA1QTZzPD;hQi=>
BA/F3	MnXFSpVv[3Srb36gZZN{[Xl?		NXXZcoVjPzJiaILz	MYnJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMEC0JO69VS5?	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
MV4-11	NEK2TZFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NG[yNY84OiCqcoO=	NYG2UGI4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JINmdGxidHn0[ZIu[my3ZTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFAvODB2MzFOwG0v	M{CxdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{W0NVk6Lz5zOUe1OFE6QTxxYU6=
MV4-11	NHjNXYlEgXSxdH;4bYNqfHliYYPzZZk>		NHL1e3c4OiCqcoO=	MmHER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUXY1NTFzIHPlcIx{KGGodHXyJFczKGi{czDifUBk\WyuIITpeIVzNWKudXWgZZN{[XluIFnDOVAhRSByLkCwOFMh\|ryPLh?=	M2jiUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkW0OFA5Lz5zOU[1OFQxQDxxYU6=
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BA/F3	MlXVSpVv[3Srb36gZZN{[Xl?		MnTFO\|IhcHK\|	NIXJdVZKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEGxJIRmdGW2aX;uJEg2PTdidH:gOVU5KHKnc3nkeYV{MSCjbnSgWlY2PEFibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO\|YYmsJGdKPTBiPTCwMlAxPiEQvF2u	NVqw[G4xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
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MDA-MB-468	M1nHN2N6fG:2b4jpZ4l1gSCjc4PhfS=>			M4DMN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJRzcXCuZTDu[YdifGm4ZTDNSGEuVUJvNE[4JINmdGy\|LDDJR\|UxKD1iMD6wNFYyKM7:TT6=	Mn3pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
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MV4-11	NVnKTopWSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MXO3NkBpenN?	M2nmXmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTW[0MVEyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlAxQSEQvF2u	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODV5MEWyOkc,OjB3N{C1NlY9N2F-
MV4-11	NW[5NGtOS3m2b4TvfIlkcXS7IHHzd4F6			M1PZSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1XPC1zMTDj[YxteyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlAxQSEQvF2u	NGfYPVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEizN\|A{QSd-MkC4N\|MxOzl:L3G+
BAF3	M3u4U2Z2dmO2aX;uJIF{e2G7		NFzES2Y4OiCqcoO=	MojJTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBXPTV7RDDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5yMEmg{txONg>?	Mm\QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
endothelial precursor cells	MVrGeY5kfGmxbjDhd5NigQ>?			NWPqRWI6UW6qaXLpeIlwdiCxZjDlcoRwfGinbHnhcEBkd3KmIHHy[YEh\m:{bXH0bY9vKGmwIHXu[I91cGWuaXHsJJBz\WO3coPvdkBk\WyuczDifUBETDNzIHPvdoQh[XKnYTDk[ZRm[3Srb36gZoF{\WRicHjlco91gXCrYzDkdpVoKGSrc3PveoVzgSCkYYPl[EBie3OjeTygTWM2OCB;IECuNFA6PiEQvF2u	NEX5XpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSwPVY3Pid-MkK0NFk3PjZ:L3G+
MDA-MB-435	NFrCRpdEgXSxdH;4bYNqfHliYYPzZZk>			NFixWJZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtOFM2KGOnbHzzMEBKSzVyIE2gNE4xODl5IN88UU4>	NWfnVYV4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PVA3PTJpPkK0PFkxPjV{PD;hQi=>
RS4-11	NXWxRlFCTnWwY4Tpc44h[XO\|YYm=		NUfL[2hMOiCqcoO=	NGn1UVRKdmirYnn0bY9vKG:oIF\MWFMh[XW2b4Doc5NxcG:{eXzheIlwdiCrbjDoeY1idiCUU{StNVEh[2WubIOgZYZ1\XJiMjDodpMh[nliZXzlZ5Rzd2OqZX3pcJVucW6nc3PlcoNmKGG\|c3H5MEBKSzVyIE2gNE4xODl7IN88UU4>	NFO1bGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[1OFQxQCd-MUm2OVQ1ODh:L3G+
MV4-11	M1LXSGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NFLsOoM4OiCqcoO=	MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2YND2xNUBk\WyuczDh[pRmeiB5MjDodpMh[nliQ3XscJRqfGW{LVfsc{BtfW2rbnXzZ4VvfCClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFEh\|ryPLh?=	NIKyUIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUmzOVc4Oid-Mkm5N\|U4PzJ:L3G+
BA/F3	NUDOUnN6TnWwY4Tpc44h[XO\|YYm=		MnjsO\|IhcHK\|	MknyTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiB7IFHZOVAzKHSxIEWwN{BqdnOncoTpc44h[W6mIG[2OVQhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkCxNkDPxE1w	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
Kasumi-1	M3zHVGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MXm3NkBpenN?	NHvCcWFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvhd5VucS1zIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjBzNjFOwG0v	NVP1UoNuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1O\|A2OjZpPkKwOVcxPTJ4PD;hQi=>
RS4-11	NV3B[ndFTnWwY4Tpc44h[XO\|YYm=			M1TGXmlvcGmkaYTpc44hd2ZiRlzUN{BifXSxcHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKFKVND2xNUBk\WyuczDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXNuIFnDOVAhRSByLkCxOkDPxE1w	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh\|M{CzPUc,OjB6M{OwN\|k9N2F-
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U251	MmT1SpVv[3Srb36gZZN{[Xl?		NUjTR\|BCPjBibXnudy=>	NH7VS\|ZKdmirYnn0bY9vKG:oIG\FS2YucW6mdXPl[EBXTUeIUkKgZYN1cX[jdHnvckBqdiCqdX3hckBWOjVzIHPlcIx{KHC{ZYTy[YF1\WRiZn;yJFYxKG2rboOg[o9tdG:5ZXSgZpkhXkWJRjDh[IRqfGmxbjDhcoQhdWWjc4Xy[YQh[W[2ZYKgNVAhdWmwczDifUBGVEmVQTygTWM2OCB;IECuNFE5QSEQvF2u	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7OEi2PUc,OzByOUi4Olk9N2F-
U251	MkTlSpVv[3Srb36gZZN{[Xl?		NG\mR4c3OCCvaX7z	NYLydnh7UW6qaXLpeIlwdiCxZjDWSWdHWi1{IHnuJIh2dWGwIGWyOVEh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIG\FS2YhcW6mdXPl[EBxcG:\|cHjvdplt[XSrb36gdJJmcW6ldXLheIVlKG[xcjC2NEBucW6\|IH\vcIxwf2WmIHL5JHZGT0ZiYXTkbZRqd25ibXXhd5Vz\WRiYX\0[ZIhOTBibXnud{BjgSCHTFnTRUBu\XSqb3SsJGlEPTBiPTCwMlAyQDlizszNMi=>	NGizO3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i5OFU5QSd-Mke4PVQ2QDl:L3G+
U251	NH7o[4tHfW6ldHnvckBie3OjeR?=		MV22NEBucW5?	Mm\RTY5pcWKrdHnvckBw\iCYRVfGVlIhcW5iaIXtZY4hXTJ3MTDj[YxteyClb33wc5Vv\CCycnX0doVifGWmIH\vdkA3OCCvaX6gZoVnd3KnIG\FS2Yhe3SrbYXsZZRqd25iZn;yJFExKG2rboOgZpkheGixc4Doc5R6em:\|aX7lJGVNUVODIHP5eI9jdG:2IH3leIhw\CxiSVO1NEA:KDBwMEG4PUDPxE1w	NHXtVZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4NlUyQSd-MkW4PFI2OTl:L3G+
BAF3	MkC2SpVv[3Srb36gZZN{[Xl?		MYW3NkBpenN?	NEDxVVBKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjT2lVKFZ4NUTBJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCCycn;sbYZmemG2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwN0OFS{igZZN{[XluIFfJOVAhRSByLkCyJO69VS5?	M1[0flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
MDA-MB-231	NUK5UmRyS3m2b4TvfIlkcXS7IHHzd4F6			NEfye\|REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckB1emmybHWgcoVo[XSrdnWgUWRCNU2ELUKzNUBk\WyuczygTWM2OCB;IECuNFIzOyEQvF2u	M4POSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
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MV4-11	MXnDfZRwfG:6aXPpeJkh[XO\|YYm=		MWW0PEBpenN?	MmXrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUXY1NTFzIHPlcIx{KGG\|c3Xzd4VlKGG\|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB{NEOg{txONg>?	M{K5cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEi5PFExLz5{NUC4PVgyODxxYU6=
BA/F3	M1;yemZ2dmO2aX;uJIF{e2G7		Mly3O\|IhcHK\|	NGexe3NKdmirYnn0bY9vKG:oIFvpeEBXPTZyRDDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGmwY4XiZZRm\CCob4KgO\|IhcHK\|IHL5JG1VWyCjc4PhfUwhT0l3MDC9JFAvODJ5IN88UU4>	NVnidohNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
MCF7	M3nEcWN6fG:2b4jpZ4l1gSCjc4PhfS=>			MkXtR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSXIueG:\|aYTpeoUhVUOINzDj[YxteyxiSVO1NEA:KDBwMEK3NUDPxE1w	M2nWZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
MCF7	NWnReYpRS3m2b4TvfIlkcXS7IHHzd4F6			MkXSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6geIF5d2mmLYLld4l{fGGwdDDNR2Y4KGOnbHzzMEBKSzVyIE2gNE4xOjl\|IN88UU4>	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7ME[1Nkc,OjR6OUC2OVI9N2F-
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primary leukemia cells	NYfZZYJZS3m2b4TvfIlkcXS7IHHzd4F6		NIfFN3I4OiCqcoO=	Mom4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdJJqdWG{eTDs[ZVs\W2rYTDj[YxteyCrc3;sZZRm\CCocn;tJIFkfXSnIH35[YxwcWRibHX1b4VucWFicHH0bYVvfCCneIDy[ZN{cW6pIIfpcIQhfHmyZTDGUHQ{KGG\|c3Xzd4VlKGG\|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBtfWOrZnXyZZNmKGG\|c3H5MEBKSzVyIE2gNE4xOyEQvF2u	M4PXcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkKxNlAyLz5{MkKyNVIxOTxxYU6=
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MV4-11	NGfpNGtCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		Mn\yO\|IhcHK\|	MkXLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPVkStNVEh[2WubIOgbIFz[m:{aX7nJGZNXDNiSWTEJI12fGGwdDDh[pRmeiB5MjDodpMh[nliTWTTJIF{e2G7LDDJR\|UxKD1iMD6wN\|g2KM7:TT6=	NXrS[m1QRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN\|g{OjhpPkK4NFM5OzJ6PD;hQi=>
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BAF3	NETq[5JHfW6ldHnvckBie3OjeR?=		NUnkN\|FqPzJiaILz	NWLnb4VzUW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgZ2tKXCCWNkewTU9XPTV7RDDkc5VjdGVibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFAvODV\|IN88UU4>	NFroelQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
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BA/F3	Ml\kSpVv[3Srb36gZZN{[Xl?		MWW3NkBpenN?	NX3NemIzUW6qaXLpeIlwdiCxZjDLbZQhTDhzNm[gcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEeLNUCgQUAxNjZ\|ODFOwG0v	NWLrUFlyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
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BA/F3	NHy3NYJHfW6ldHnvckBie3OjeR?=		NHLNc\|Y4OiCqcoO=	MmLwTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiBzMTDk[YxmfGmxbjCoOVU4KHSxIEW1PEBz\XOrZIXld{kh[W6mIGm4NlNFKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD63PFIh\|ryPLh?=	NXjXPJBxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
NCI-H3122	NWToU\|lWSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M1XPNlczKGi{cx?=	NEHlbWpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOzF{MjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC56MzFOwG0v	MmjGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MES5OlEoRjJ2OUC0PVYyRC:jPh?=
Rec1	NWHQNodHSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NVTMWZVSPzJiaILz	MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFKnY{GgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwN0OFS{igZZN{[XluIFfJOVAhRSByLki3JO69VS5?	M2nqUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
RS4:11	MUHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NHfZTpE4OiCqcoO=	MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFKVNEqxNUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMTFOwG0v	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODV5MEWyOkc,OjB3N{C1NlY9N2F-
K562	Mn7sRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NWC0ZoQ1PzJiaILz	NXnY[lVCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMJIRmeGWwZHXueEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubz;DR2s5KGG\|c3H5MEBIUTVyIE2gNUDPxE1w	Ml\3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
NCI-H526	MoXtRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NXXQRmxlPzJiaILz	M{DoR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg2OjZiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEvODFizszNMi=>	NVjNXFV5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFQ6PjFpPkK0PVA1QTZzPD;hQi=>
primary leukemia cells	MoPsR5l1d3SxeHnjbZR6KGG\|c3H5		NWXDeHFEPzJiaILz	MlrMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdJJqdWG{eTDs[ZVs\W2rYTDj[YxteyCrc3;sZZRm\CCocn;tJIFkfXSnIH35[YxwcWRibHX1b4VucWFicHH0bYVvfCCneIDy[ZN{cW6pIF\MWFMuTDh\|NWmgcZV1[XSrb36gZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IHz1Z4ln\XKjc3WgZZN{[XluIFnDOVAhRSBzLkGg{txONg>?	NUTtWJlkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlEzODFpPkKyNlIyOjBzPD;hQi=>
KU812	NELOcnBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NWPLV\|lqPzJiaILz	NVPhZo1RSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMJIRmeGWwZHXueEBpfW2jbjDLWVgyOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFEvOSEQvF2u	NUfTT2RMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
BA/F3	MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MoHQO\|IhcHK\|	M1fybGdzd3e2aDDpcohq[mm2aX;uJI9nKG2xdYPlJGJCN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnuZ49zeG:{YYTpc44hd2ZiW{PIYZRpgW2rZHnu[UBqdmOxcoDvdoF1cW:wIHHmeIVzKDd{IHjyd{BjgSCuaYH1bYQhe2OrboTpcIxifGmxbjDjc5VvfGmwZzygTWM2OCB;IEGuNkDPxE1w	MkD2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMUewNFQoRjJyMUG3NFA1RC:jPh?=
MEG01	M4ja[mFvfGmycn;sbYZmemG2aY\lJIF{e2G7		Ml34O\|IhcHK\|	MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKFUj3BRmwh\GWyZX7k[Y51KE2HR{CxJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMT6yJO69VS5?	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
Sf9	M3Hr[WZ2dmO2aX;uJIF{e2G7			MV;Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEircz30ZYdo\WRiUlXUJIV5eHKnc4Pl[EBqdiCVZkmgbY5{\WO2IHPlcIx{NCCLQ{WwJF0hOS5\|IN88UU4>	NGO3dFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGxO\|AxPCd-MkCxNVcxODR:L3G+
HT-29	NETYb41EgXSxdH;4bYNqfHliYYPzZZk>		NUfJdnQ5PzJiaILz	MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCxMlMh\|ryPLh?=	MojKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4MkG4PFAoRjJzNkKxPFgxRC:jPh?=
SW620	M37iSmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MlXoOFghcHK\|	NHLDWlRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXOlIxKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO\|YYmsJGdKPTBiPTCxMlMh\|ryPLh?=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
IM9	NEDkUItCdnSrdIXtc5Ih[XO\|YYm=			NXXVNnhqSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTW06KGOnbHzzMEBKSzVyIE2gNU4{PSEQvF2u	M4HN[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEWwOFY{Lz5{MUS1NFQ3OzxxYU6=
BAF3	MkC2SpVv[3Srb36gZZN{[Xl?		M3rGe\|czKGi{cx?=	NVX4OppPUW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgZ2tKXCCGOEG2WkBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMT6zPEDPxE1w	M3LPWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
HT-29	M4i1TmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NXrtR21jPzJiaILz	MkfBRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKVD2yPUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMT60O{DPxE1w	NGDNTHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1OCd-MkO5PVkxPDB:L3G+
HT-29	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NXS4WVc{PDhiaILz	M37aN2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IEGuOkDPxE1w	NEPpNlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
HT-29	Mke5R5l1d3SxeHnjbZR6KGG\|c3H5			MmDQR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMT63JO69VS5?	NXnlNWZiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5NlA5ODBpPkK2PVIxQDByPD;hQi=>
U937	MWPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MmT2O\|IhcHK\|	MoP1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCXOUO3JINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMT63JO69VS5?	M4L2NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
MCF7	MnTIRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MlrSOFghcHK\|	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDJizszNMi=>	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
MDA-MB-435	NFSxR5RCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NHvBS3g1QCCqcoO=	NWLXTYZJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEO1JINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSB{IN88UU4>	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
GIST48B	NEDOeVFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MYC3NkBpenN?	MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeLU2S0PGIh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCyMlAyKM7:TT6=	MnHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
CHO	M3r5VWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NHn1[oc4OiCqcoO=	NEL1OmVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGNJVyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFIvODNizszNMi=>	MkHEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
KB-3-1	MV7DfZRwfG:6aXPpeJkh[XO\|YYm=		NWDxOWVVPzJiaILz	MlnCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVE1oeC2wZXfheIl3\SCNQj2zMVEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuN{DPxE1w	M4C3V\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m3N\|IzLz5zOUO5O\|MzOjxxYU6=
K562	M2jTUWFvfGm2dX3vdkBie3OjeR?=			NWfRfYh2SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{whUUN3MDC9JFIvPDFizszNMi=>	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR3MES2N{c,OjF2NUC0OlM9N2F-
A549	NGS2OGhEgXSxdH;4bYNqfHliYYPzZZk>		NIPFXJY4OiCqcoO=	MonLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOi52NDFOwG0v	NF;5TI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNlQ1OSd-MkO2NFI1PDF:L3G+
T24	M3\nT2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		NXL3WWtoPzJiaILz	NEi5fXhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGSyOEBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMj60OEDPxE1w	NGnsVYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1OCd-MkO5PVkxPDB:L3G+
CHL	MlzjRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NYnpZnRCPzJiaILz	MoPQRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDDTGwh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCyMlQ5KM7:TT6=	NX;1VlEzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
ACHN	M4O3PWN6fG:2b4jpZ4l1gSCjc4PhfS=>		M{jaWFYh\GG7cx?=	NVHTW5RPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSUOKTjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygeoli[mmuaYT5JIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCyMlUh\|ryPLh?=	Mor1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|NkCxNFQoRjJ\|M{[wNVA1RC:jPh?=
Bel7402	NFLVcWZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MmjxO\|IhcHK\|	MkLrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCEZXy3OFAzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCyMlY4KM7:TT6=	M2WydlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
H460	NYXPdmxXS3m2b4TvfIlkcXS7IHHzd4F6		MW[3NkBpenN?	MoL0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTFQ3OCClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCyMlch\|ryPLh?=	MmPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4MkG4PFAoRjJzNkKxPFgxRC:jPh?=
BAF3	M{G2eWFvfGmycn;sbYZmemG2aY\lJIF{e2G7			MUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDRkOgZ4VtdHNuIFfJOVAhRSB{Lke4JO69VS5?	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
HuH7	M3LUW2FvfGmycn;sbYZmemG2aY\lJIF{e2G7			NV3SSXJ3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIeWg4KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNwMEOg{txONg>?	NEfZ[Zg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC1PVgxOyd-M{CwOVk5ODN:L3G+
HuH7	MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NFPuV2Q1QCCqcoO=	NELXcmhIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJfUh5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{NjB\|IN88UU4>	MkK3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7NU[zOFQoRjJ5OUW2N\|Q1RC:jPh?=
OVCAR3	Mo\iRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		Ml\JOFghcHK\|	NVOyPWE3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDPWmNCWjNiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFMvOiEQvF2u	MmDvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3NkC2NlcoRjJ{NU[wOlI4RC:jPh?=
HL60	NGHkSoFCdnSrdIXtc5Ih[XO\|YYm=			NIDvZWdCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzMEBKSzVyIE2gN{42OyEQvF2u	M4XafVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEWwOFY{Lz5{MUS1NFQ3OzxxYU6=
BxPC3	Mlv1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NUTofnZTPzJiaILz	MoC1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCEeGDDN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMz62N{DPxE1w	MkPKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7OUmwOFAoRjJ\|OUm5NFQxRC:jPh?=
MDA-MB-231	NUPKR\|NJS3m2b4TvfIlkcXS7IHHzd4F6		M3TYR\|czKGi{cx?=	MkXoR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB\|Lkeg{txONg>?	MoHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4MkG4PFAoRjJzNkKxPFgxRC:jPh?=
HepG2	NHfwfFhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M4PNfFczKGi{cx?=	M122OWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS\|Ih[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOuPFEh\|ryPLh?=	NFHiOXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEW3NFUzPid-MkC1O\|A2OjZ:L3G+
UACC257	NVK2bI57SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NVzlNHM2PDhiaILz	MnjzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCXQVPDNlU4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO\|YYmsJGdKPTBiPTC0JO69VS5?	NXHDOWFQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OlA3OjdpPkKyOVYxPjJ5PD;hQi=>
RCC4	M3\xUmFvfGmlYX7j[ZIh[XO\|YYm=		Ml\3OFghcHK\|	NECyS2VCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gVmNEPCClZXzsd{Bi\nSncjC0PEBpenNiYomgXHRVKGG\|c3H5MEBKSzVyIE2gOEDPxE1w	NHXDVYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOyOVYxOCd-MkizNlU3ODB:L3G+
KBV1	MWnDfZRwfG:6aXPpeJkh[XO\|YYm=		MlPqO\|IhcHK\|	MlTTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVE1odHmlb4Dyc5RmcW5vZYjwdoV{e2mwZzDLRnYyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTC0MlEh\|ryPLh?=	M1Xhe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m3N\|IzLz5zOUO5O\|MzOjxxYU6=
A498	M1XLe2N6fG:2b4jpZ4l1gSCjc4PhfS=>		M2Hy[\|czKGi{cx?=	MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFk5KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTC0MlMh\|ryPLh?=	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR6OU[yOkc,OjN2OEm2NlY9N2F-
NCI-H460	M2XCUmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		Mm\HO\|IhcHK\|	NUDSUXltSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDR4MDDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPC5\|MTFOwG0v	NYPDd5ZMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFQ6PjFpPkK0PVA1QTZzPD;hQi=>
MDA-MB-231	NX;YTVBYSW62aYT1cY9zKGG\|c3H5			M1;qSGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNuIFnDOVAhRSB2LkWxJO69VS5?	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR3MES2N{c,OjF2NUC0OlM9N2F-
L02	MWfDfZRwfG:6aXPpeJkh[XO\|YYm=		MV:3NkBpenN?	NYfVSXFxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVDB{IHPlcIx{KGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDRwNkKg{txONg>?	MlTiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4NEO2N\|koRjJ5NkSzOlM6RC:jPh?=
HT-29	M2O5eGN6fG:2b4jpZ4l1gSCjc4PhfS=>		MV60PEBpenN?	Mo\HR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR\|UxKD1iND63JO69VS5?	NVLGc5F2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wNFkyPjRpPkK2NFA6OTZ2PD;hQi=>
HuH7	MVrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M4D1SlQ5KGi{cx?=	M1LFeGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSIXIO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iND63NFch\|ryPLh?=	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTB3N{C0Nkc,OjlyNUewOFI9N2F-
HCT116	MYTDfZRwfG:6aXPpeJkh[XO\|YYm=		NVXGUHV[PzJiaILz	M2W2NGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iND63NUDPxE1w	NGH1OJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNlQ1OSd-MkO2NFI1PDF:L3G+
BGC	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MXu3NkBpenN?	MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKJQzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPC55ODFOwG0v	MoHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7OUmwOFAoRjJ\|OUm5NFQxRC:jPh?=
BA/F3	MlvFR5l1d3SxeHnjbZR6KGG\|c3H5		M2jXcFczKGi{cx?=	MV7DfZRwfG:6aXPpeJkhcW5ibX;1d4UheGG{ZX70ZYwhSkFxRkOgZ4VtdHNiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwJF0hPC55OEmg{txONg>?	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
HL60	MmraR5l1d3SxeHnjbZR6KGG\|c3H5		NUflPYRSPzJiaILz	MUHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFQvQTVizszNMi=>	M4HmV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkSzOlM6Lz5{N{[0N\|Y{QTxxYU6=
A375	Ml;jWI95cWOrdImgZYdicW6\|dB?=		MlntO\|IhcHK\|	NVr3Vm9HXG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBN\|c2KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYJtfWViYYPzZZktKEmFNUCgQUA2NjRizszNMi=>	NFG0cIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[1OFQxQCd-MUm2OVQ1ODh:L3G+
HepG2	NXK0N4dZSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NF3YUnY4OiCqcoO=	NE\ac5BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTC1MlYyKM7:TT6=	NXXNSoZlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDBpPkKzPVk6ODRyPD;hQi=>
HCT116	MYXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			M1\RUmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwNkKg{txONg>?	NVrFNmlVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOVk5ODNpPkOwNFU6QDB\|PD;hQi=>
HCT116	MkTKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M1rWPVQ5KGi{cx?=	NHzJVXZIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwNkKg{txONg>?	NHLvfYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m1OlM1PCd-Mke5OVY{PDR:L3G+
ACHN	MorLR5l1d3SxeHnjbZR6KGG\|c3H5		MUO3NkBpenN?	NYqwUJMxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSUOKTjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS55IN88UU4>	NYrPTVFwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PFk3OjZpPkKzOFg6PjJ4PD;hQi=>
HK2	MmTnRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NIWxTIU4OiCqcoO=	MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiNMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS56NTFOwG0v	NG\6e2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwOFk3OSd-MkS5NFQ6PjF:L3G+
GISTT1	MojUR5l1d3SxeHnjbZR6KGG\|c3H5		NHe5fJU4OiCqcoO=	MoryR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gS2lUXFRzIHPlcIx{KGijcnLvdolv\yCNSWSgSFgyPkVibYX0ZY51KGG\|c3Xzd4VlKGG\|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldmdtdyCjc4PhfUwhT0l3MDC9JFUvQDhizszNMi=>	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl7MUS2OUc,Ojh7OUG0OlU9N2F-
MDA-MB-231	MnPTRY51cWOjbnPldkBie3OjeR?=		MWm0PEBpenN?	NIfaZYNCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB2ODDodpMh[nliWGTUJIF{e2G7LDDJR\|UxKD1iNjFOwG0v	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN{NU[wNEc,Ojh\|MkW2NFA9N2F-
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Bel7402	MU\QbI91d2O7dH;0c5hq[2m2eTDhd5NigQ>?		M4LtN\|UhcHK\|	MoX3VIhwfG:leYTveI95cWOrdImgZYdicW6\|dDDoeY1idiCEZXy3OFAzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JJBz\WmwY4XiZZRm\CCob4KgOUBpenNid3n0bEBk\WyuczDmc4xtd3enZDDifUBWXkFvMTDpdpJi\GmjdHnvckBifCB\|LkCgcXcw[21pMjDmc5IhOjBibXnud{Bu\WG\|dYLl[EBi\nSncjC0PEBpenNiYomgR2NMQCCjc4PhfUwhTUN3MDC9JFEyKM7:TT6=	MljuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OESwPFUoRjJ4NUi0NFg2RC:jPh?=
A375	NXzMdIl4S3m2b4TvfIlkcXS7IHHzd4F6		NGPzNHE1QCCqcoO=	NGX6V\|hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCOzd3IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOS53ODFOwG0v	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR6M{[wPEc,OjJ2OEO2NFg9N2F-
SF539	M3u0OWZ2dmO2aX;uJIF{e2G7		MnPnNVAhdWmwcx?=	NVnXPHM6UW6qaXLpeIlwdiCxZjDQSGdHWmKndHGgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIGPGOVM6KGOnbHzzJIFnfGW{IEGwJI1qdnNiYomgSmxKW0FuIFnDOVAhRSBzMj6yJO69VS5?	M33LRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNECzO\|AxLz5{MESwN\|cxODxxYU6=
A431	MWXGeY5kfGmxbjDhd5NigQ>?			MYDJcohq[mm2aX;uJI9nKFCGR1\SZoV1[SCneIDy[ZN{\WRiaX6gbJVu[W5iQUSzNUBk\WyuczygTWM2OCB;IEGyMlIh\|ryPLh?=	NWT5NmJCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1OVgxPzJpPkKwOVU5ODd{PD;hQi=>
SF-539	MmXESpVv[3Srb36gZZN{[Xl?		MX62NEBucW6\|	M2n5dmlvcGmkaYTpc44hd2ZiUFTHSnJj\XSjIIT5do9{cW6nIHvpcoF{\SCjY4Tpeol1gSCrbjDQSGdHNUKELYP0bY12dGG2ZXSgbJVu[W5iU1[tOVM6KGOnbHzzJIFnfGW{IE[wJI1qdnNiYomgSWxKW0FuIFnDOVAhRSBzMj6yJO69VS5?	NELONWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKwOFc1OSd-MkKyNFQ4PDF:L3G+
A549	NFTkfJBEgXSxdH;4bYNqfHliYYPzZZk>		NYLiWnl7PDhiaILz	M4n3WmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEzNjN3IN88UU4>	NVe4OIJzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFM3ODhpPkKyOFg{PjB6PD;hQi=>
PC3	M3S4OmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MoXnOFghcHK\|	MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR\|Mh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMUKuOkDPxE1w	NXrXRpY1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2N\|k{PjlpPkK3OlM6OzZ7PD;hQi=>
LNCAP	NI[4TndEgXSxdH;4bYNqfHliYYPzZZk>		MlTmOFghcHK\|	MmDDR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG5ESVBiY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF{Lk[xJO69VS5?	MlrWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd{MUC0N\|goRjJ5MkGwOFM5RC:jPh?=
PANC1	MUPQbI91d2O7dH;0c5hq[2m2eTDhd5NigQ>?		MUK1JIhzew>?	MnnCVIhwfG:leYTveI95cWOrdImgZYdicW6\|dDDoeY1idiCSQV7DNUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDwdoVqdmO3YnH0[YQh\m:{IEWgbJJ{KHerdHigZ4VtdHNiZn;scI94\WRiYomgWXZCNTFiaYLyZYRq[XSrb36gZZQhOy5yIH3XM4NuLzJiZn;yJFIxKG2rboOgcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IFPDT\|gh[XO\|YYmsJGVEPTBiPTCxN{DPxE1w	M4rZZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUi0NFg2Lz5{NkW4OFA5PTxxYU6=
HepG2	MnL5R5l1d3SxeHnjbZR6KGG\|c3H5		NFS3PZI1QCCqcoO=	NWfHfmFJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF\|LkK0JO69VS5?	NYfNfFlmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFM3ODhpPkKyOFg{PjB6PD;hQi=>
endothelial precursor cells	NUXEXlNLTnWwY4Tpc44h[XO\|YYm=			NIfvVVNKdmirYnn0bY9vKG:oIHPlcIwhdWmpcnH0bY9vKGmwIHXu[I91cGWuaXHsJJBz\WO3coPvdkBk\WyuczDifUBQemm\|IHPlcIwhdWmpcnH0bY9vKGurdDDiZZNm\CCyaHXuc5R6eGmlIHTyeYch\Gm\|Y3;2[ZJ6KGKjc3XkJIF{e2G7LDDJR\|UxKD1iMUOuOkDPxE1w	NIGzXGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSwPVY3Pid-MkK0NFk3PjZ:L3G+
HepG2	NYPYZ4hLSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MorLOFghcHK\|	NXPSXJJzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNVMvPiEQvF2u	NV\wZoNqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwOlQ{PDdpPkK1NFY1OzR5PD;hQi=>
K562	NEnBeo1EgXSxdH;4bYNqfHliYYPzZZk>		NHTHRowzPCCqcoO=	MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCxOEDPxE1w	MlnBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NU[wNlQoRjJ6N{W2NFI1RC:jPh?=
A549	M{X0WmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MWS0PEBpenN?	MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTRwNDFOwG0v	M4PPfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NES4PVE3Lz5{N{S0PFkyPjxxYU6=
A549	MoLRR5l1d3SxeHnjbZR6KGG\|c3H5		NEXEV4E1QCCqcoO=	M4LsUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNVQvPCEQvF2u	M3rHO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkO5N\|Y6Lz5{N{[zPVM3QTxxYU6=
PANC1	M{XXbmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MU[0PEBpenN?	NX3JRXlyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEGQQ{GgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG\|c3H5MEBKSzVyIE2gNVQvQTRizszNMi=>	MlzqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEmxOlQoRjJ4MEC5NVY1RC:jPh?=
HepG2	MlXNR5l1d3SxeHnjbZR6KGG\|c3H5		NFX3VHk1QCCqcoO=	MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNVUvPCEQvF2u	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjBzOUG4PEc,OjJyMUmxPFg9N2F-
HL60	MlvVR5l1d3SxeHnjbZR6KGG\|c3H5		MmntOFghcHK\|	M1vuU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNPjBiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE2NjVizszNMi=>	NWrjUoUzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNVkyQDhpPkKyNFE6OTh6PD;hQi=>
BT549	M1zDWWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NVnxUZVqPDhiaILz	MoGyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRnQ2PDliY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE2NjVizszNMi=>	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF{OEG3N{c,OjdzMkixO\|M9N2F-
BT549	MXTDfZRwfG:6aXPpeJkh[XO\|YYm=		NWDrSmZJPDhiaILz	NEf6OVVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDXDV2OTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPS53IN88UU4>	MmO4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4M{mzOlkoRjJ5NkO5N\|Y6RC:jPh?=
BT549	NEfScZBEgXSxdH;4bYNqfHliYYPzZZk>		NXn3e\|JlPDhiaILz	MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCWFU1QSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3LkW0JO69VS5?	MmP3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2NEi5NVYoRjJ5NES4PVE3RC:jPh?=
CHO K1	NUP5OnBiTnWwY4Tpc44h[XO\|YYm=			MkPpTY5pcWKrdHnvckBw\iCoYYP0JJNw\Gm3bTDjeZJz\W62IDjJUoEqKGmwIFPobY5me2ViSHHtd5RmeiCRdnHyfUApS0iRKTDLNUBk\WyuczD0doFve2[nY4Tl[EB4cXSqIHj1cYFvKE6jdkGuOUBu\WG\|dYLl[EB2e2mwZzDJc45Yd3KtczDReYF1fHKxIHH1eI9u[XSnZDDwZZRkcCClbHHtdEBxdGG2Zn;ycUwhUUN3MDC9JFE2Njh2OEmg{txONg>?	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB6N{e1N{c,OjVyOEe3OVM9N2F-
HepG2	NFTKTYJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NEXKOWE1QCCqcoO=	NUHWZWRmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNVYvODZizszNMi=>	M1zqW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEW3OFI{Lz5{OEC1O\|QzOzxxYU6=
HepG2	NXLZUlVxS3m2b4TvfIlkcXS7IHHzd4F6		NGLQVJU1QCCqcoO=	M2XlcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEG2MlA3KM7:TT6=	NITOboI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwPVE3PCd-Mk[wNFkyPjR:L3G+
DU145	Mo\3R5l1d3SxeHnjbZR6KGG\|c3H5		NULaTZluPDhiaILz	MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCxOk4{KM7:TT6=	NUiwRXI3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2N\|k{PjlpPkK3OlM6OzZ7PD;hQi=>
DU145	NYHhbmtHS3m2b4TvfIlkcXS7IHHzd4F6		NWi4W49kPDhiaILz	MnO2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSHUyPDViY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNj6zPEDPxE1w	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR2OEmxOkc,Ojd2NEi5NVY9N2F-
DU145	Mom4R5l1d3SxeHnjbZR6KGG\|c3H5		MVG0PEBpenN?	NXy1VWN1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF4LkSg{txONg>?	M1fGUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVc{Lz5{N{GyPFE4OzxxYU6=
HCT116	MljTR5l1d3SxeHnjbZR6KGG\|c3H5		M2\PZVQ5KGi{cx?=	NVfleItZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzOD6zOUDPxE1w	NXHXSmNTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFM3ODhpPkKyOFg{PjB6PD;hQi=>
A549	NVH3bFNPS3m2b4TvfIlkcXS7IHHzd4F6		NUfTbFF6PDhiaILz	M{HqcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE5NjVizszNMi=>	Mn;YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMUmxPFgoRjJ{MEG5NVg5RC:jPh?=
U251	M1XYe2Z2dmO2aX;uJIF{e2G7		M3uzSVExKG2rboO=	NI\Se\|JKdmirYnn0bY9vKG:oIG\FS2ZTOiCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hXTJ3MTDj[YxteyCjZoTldkAyOCCvaX7zJIJ6KE[OSWPBMEBKSzVyIE2gNVgvQSEQvF2u	NXXRS5VyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFM4ODBpPkKwOFA{PzByPD;hQi=>
A431	NHnhO4tHfW6ldHnvckBie3OjeR?=			M1rPO2lvcGmkaYTpc44hd2ZiVlXHSnIzKGW6cILld5Nm\CCrbjDoeY1idiCDNEOxJINmdGy\|LDDJR\|UxKD1iMUiuPUDPxE1w	NUHwU\|dHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1OVgxPzJpPkKwOVU5ODd{PD;hQi=>
U251	M1r4TWZ2dmO2aX;uJIF{e2G7		M3vDbVYxKG2rboO=	M1X3ZmlvcGmkaYTpc44hd2ZiVlXHSnIzKHS7cn;zbY5mKGurbnHz[UBi[3Srdnn0fUBqdiCYRVfGMZN1cW23bHH0[YQhcHWvYX6gWVI2OSClZXzsd{Bi\nSncjC2NEBucW6\|IHL5JGVNUVODLDDJR\|UxKD1iMUiuPUDPxE1w	M1e4PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkC0O\|QyLz5{MkKwOFc1OTxxYU6=
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JVM-2	NFLyeI5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NX3lO\|NLUW6qaXLpeIlwdiCxZjDoeY1idiCMVl2tNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOjhwMki5PEDPxE1w	MkfLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
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TE-9	MkK3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NF:2NnVKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFM4NjB2MEGg{txONg>?	NV3DTXdqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
ES3	NGnMS5pIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MmX2TY5pcWKrdHnvckBw\iCqdX3hckBGWzNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEO3MlUxODRizszNMi=>	M2Dp[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NCI-H2141	NEf1OZpIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MWLJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkG0NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOzhwMEi0N{DPxE1w	NXHPenpLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
MPP-89	M1;5UWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			Mmi5TY5pcWKrdHnvckBw\iCqdX3hckBOWFBvOEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQzNjB3OE[g{txONg>?	NEn5TXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
SK-MEL-2	M2jafmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M{HxcWlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTVXMMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDR{Lk[0NFUh\|ryPLh?=	NELsT4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
LC-1F	MkHVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MoL5TY5pcWKrdHnvckBw\iCqdX3hckBNSy1zRjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gOFMvOzZ6MjFOwG0v	MmHvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NH-12	M1r0Tmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NEjHUW1KdmirYnn0bY9vKG:oIHj1cYFvKE6KLUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1Oy57M{W5JO69VS5?	NVTZXHplRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
RKO	MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			Mof2TY5pcWKrdHnvckBw\iCqdX3hckBTU09iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IES0MlEzPTJizszNMi=>	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
KM-H2	MkjNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M3[xeWlvcGmkaYTpc44hd2ZiaIXtZY4hU01vSEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ1Njl3N{eg{txONg>?	NVnBSZdRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
SK-UT-1	MnPjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NXrzWZpEUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3VWE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB2OT64PFI2KM7:TT6=	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-AKT / AKT / p-ERK / ERK ; PubMed: 24759734 PLoS One Effect of 72 h treatment with sunitinib on SH-SY5Y, SK N BE(2), SK-N-AS and IMR-32 NB cell lines analyzed by Western blot with pSer(473)Akt, Akt, pThr202/Thr204 Erk1/2 and Erk1/2 antibodies. β-actin was used as a loading control. p-GSK3β / GSK3β / MYCN ; PubMed: 24759734 PLoS One Effect of sunitinib on GSK3β phosphorylation and on MYCN total protein in MYCN amplified NB cell lines. p-STAT3 / STAT3 / p-Src / Src / p-AKT / AKT / p-ERK / ERK ; PubMed: 19244102 Cancer Res Sunitinib reduced Stat3 and Src activity, with no dramatic reduction of AKT, MAPK and JAK signaling in 786-O cells. Tumor cells were treated with sunitinib at indicated concentrations for 2 h (left panels) or 24 h (right panels). Total cell lysates were prepared and western blots were performed using relevant antibodies to detect total protein levels, with β-actin used as the loading control.	24759734 19244102
Growth inhibition assay	Cell viability; PubMed: 24369536 Biomed Res Int Isolated effects of sunitinib malate on urinary bladder-cancer cell lines viability, assessed by using the MTT assay. The data shown and bars represent the mean values ± SD (SD: standard deviation). *P < 0.05 versus untreated cells.	24369536

In vivo

Consistent with the substantial and selective inhibition of VEGFR2 or PDGFR phosphorylation and signaling in vivo, Sunitinib (20-80 mg/kg/day) exhibits broad and potent dose-dependent anti-tumor activity against a variety of tumor xenograft models including HT-29, A431, Colo205, H-460, SF763T, C6, A375, or MDA-MB-435. Sunitinib dosing at 80 mg/kg/day for 21 days leads to complete tumor regression in six of eight mice, without tumor re-growing during a 110-day observation period after the end of treatment. Second round of treatment with Sunitinib remains efficacious against tumors that are not fully regressed during the first round of treatment. Sunitinib treatment results in significant decrease in tumor MVD, with ~40% reduction in SF763T glioma tumors. SU11248 treatment results in a complete inhibition of additional tumor growth of luciferase-expressing PC-3M xenografts, despite no reduction in tumor size. ^[2] Sunitinib treatment (20 mg/kg/day) dramatically suppresses the growth subcutaneous MV4;11 (FLT3-ITD) xenografts and prolongs survival in the FLT3-ITD bone marrow engraftment model. ^[3]

Protocol

Kinase Assay: ^[1]	- Collapse Biochemical Tyrosine Kinase Assays: IC50 values for Sunitinib against VEGFR2 (Flk-1) and PDGFRβ are determined using glutathione S-transferase fusion proteins containing the complete cytoplasmic domain of the RTK. Biochemical tyrosine kinase assays to quantitate the trans-phosphorylation activity of VEGFR2 (Flk-1) and PDGFRβ are performed in 96-well microtiter plates precoated (20 μg/well in PBS; incubated overnight at 4 °C) with the peptide substrate poly-Glu,Tyr (4:1). Excess protein binding sites are blocked with the addition of 1-5% (w/v) BSA in PBS. Purified GST-fusion proteins are produced in baculovirus-infected insect cells. GST-VEGFR2 and GST-PDGFRβ are then added to the microtiter wells in 2 × concentration kinase dilution buffer consisting of 100 mM HEPES, 50 mM NaCl, 40 μM NaVO₄, and 0.02% (w/v) BSA. The final enzyme concentration for GST-VEGFR2 or GST-PDGFRβ is 50 ng/mL. Twenty-five μL of diluted Sunitinib are subsequently added to each reaction well to produce a range of inhibitor concentrations appropriate for each enzyme. The kinase reaction is initiated by the addition of different concentrations of ATP in a solution of MnCl₂ so that the final ATP concentrations spanned the Km for the enzyme, and the final concentration of MnCl₂ is 10 mM. The plates are incubated for 5-15 minutes at room temperature before stopping the reaction with the addition of EDTA. The plates are then washed three times with TBST. Rabbit polyclonal antiphosphotyrosine antisera are added to the wells at a 1:10,000 dilution in TBST containing 0.5% (w/v) BSA, 0.025% (w/v) nonfat dry milk, and 100 μM NaVO₄ and incubated for 1 hour at 37 °C. The plates are then washed three times with TBST, followed by the addition of goat antirabbit antisera conjugated with horseradish peroxidase (1:10,000 dilution in TBST). The plates are incubated for 1 hour at 37 °C and then washed three times with TBST. The amount of phosphotyrosine in each well is quantitated after the addition of 2,2′-azino-di-[3-ethylbenzthiazoline sulfonate] as substrate.
Cell Research: ^[3]	- Collapse Cell lines: RS4;11, MV4;11, and OC1-AML5 Concentrations: Dissolved in DMSO, final concentrations ~10 μM Incubation Time: 24 and 48 hours Method: Cells are starved overnight in medium containing 0.1% FBS prior to addition of Sunitinib and FL (50 ng/mL; FLT3-WT cells only). Proliferation is measured after 48 hours of culture using the Alamar Blue assay or trypan blue cell viability assays. Apoptosis is measured 24 hours after Sunitinib addition by Western blotting to detect cleavage of poly (ADP-ribose) polymerase (PARP) or levels of caspase-3. (Only for Reference)
Animal Research: ^[2]	- Collapse Animal Models: Female nu/nu mice implanted s.c. with HT-29, A431, Colo205, H-460, SF763T, C6, A375, or MDA-MB-435, and male nu/nu mice bearing luciferase-expressing PC-3M tumors Dosages: ~80 mg/kg Administration: Orally once daily (Only for Reference)

References

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Solubility (25°C)

In vitro	DMSO	25 mg/mL warmed (62.73 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+corn oil For best results, use promptly after mixing.	0.875mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Sunitinib SDF

Molecular Weight	398.47
Formula	C₂₂H₂₇FN₄O₂
CAS No.	557795-19-4
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	SU11248
Smiles	CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C

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Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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The Serial Dilution Calculator Equation

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Computed Result

C1=C0/X	C1:	LOG(C1):
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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04669366	Not yet recruiting	Drug: sunitinib\|Drug: axitinib	Kidney Neoplasms	Pfizer	December 15 2020	--
NCT04633122	Recruiting	Drug: Ripretinib\|Drug: Sunitinib	Gastrointestinal Stromal Tumor(GIST)	Zai Lab (Shanghai) Co. Ltd.	November 25 2020	Phase 2
NCT04115189	Active not recruiting	Drug: Sunitinib	Metastatic Renal Cell Carcinoma ( mRCC)	Pfizer	December 13 2019	--
NCT03916458	Completed	--	Carcinoma Renal Cell	Pfizer	December 17 2019	--
NCT04033991	Active not recruiting	Drug: Sunitinib\|Drug: Axitinib	Carcinoma\|Renal Cell	Pfizer	September 27 2019	--
NCT03900793	Recruiting	Drug: Losartan\|Drug: Sunitinib	Osteosarcoma	University of Colorado Denver\|National Cancer Institute (NCI)	August 22 2019	Phase 1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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