Scopolamine (LSM-4015) HBr

For research use only.

Catalog No.S2508 Synonyms: NSC 61806

4 publications

Scopolamine (LSM-4015) HBr Chemical Structure

CAS No. 114-49-8

Scopolamine HBr (LSM-4015, NSC 61806) is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.

Selleck's Scopolamine (LSM-4015) HBr has been cited by 4 publications

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Biological Activity

Description Scopolamine HBr (LSM-4015, NSC 61806) is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.
Targets
mAChR [1]
55.3 nM

Protocol

Solubility (25°C)

In vitro DMSO 76 mg/mL (197.78 mM)
Water 76 mg/mL (197.78 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 384.26
Formula

C17H21NO4.HBr

CAS No. 114-49-8
Storage powder
in solvent
Synonyms NSC 61806
Smiles CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4.Br

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04999449 Not yet recruiting Drug: Scopolamine|Drug: Placebo Scopolamine|Motion Sickness Dartmouth-Hitchcock Medical Center August 2021 Phase 1
NCT04314713 Recruiting Drug: Scopolamine Hydrobromide Trihydrate Scopolamine Causing Adverse Effects in Therapeutic Use U.S. Army Medical Research and Development Command June 8 2020 Phase 1
NCT03874130 Recruiting Drug: Scopolamine Major Depressive Disorder (MDD) Repurposed Therapeutics Inc. August 1 2018 Phase 1
NCT03131050 Completed Drug: Scopolamine|Drug: Escitalopram|Drug: Saline Major Depressive Disorder Capital Medical University March 15 2017 Phase 4

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AChR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID