Home GPCR & G Protein S1P Receptor agonist Sphingosine-1-phosphate

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Sphingosine-1-phosphate S1P Receptor agonist

Cat.No.E1999

Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand toGPR3, GPR6 and GPR12. It enhances GPR3-, GPR6-, and GPR12-mediated intracellular Ca²⁺ mobilization and regulates essential cellular processes such as proliferation, migration, cytoskeletal organization, adherens junction assembly, and morphogenesis.
Sphingosine-1-phosphate S1P Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 379.47

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Quality Control

Batch: Purity: 99.57%
99.57

Solubility

In vitro
Batch:

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 379.47 Formula

C18H38NO5P

 Storage (From the date of receipt)
CAS No. 26993-30-6 Download SDF Storage of Stock Solutions

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Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-01-13)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07335952 COMPLETED
Rheumatoid Arthritis
Peking University People's Hospital
 2024-09-02 PHASE2
NCT06930430 COMPLETED
Sphingosine 1-phosphate; Interleukin 1-beta; Gingival Crevicular Fluid; Non-surgical Periodontal Therapy; Split-mouth Design
Ondokuz Mayıs University
 2023-05-15
NCT04134351 UNKNOWN
Asthma
Guy's and St Thomas' NHS Foundation Trust
 2020-02-04
NCT04007328 UNKNOWN
Pneumonia, Bacterial
Taipei Medical University WanFang Hospital
 2019-06-15 PHASE2; PHASE3

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