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Sucralfate

Name: Sucralfate
SKU: S4670
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Cat.No.S4670

Sucralfate(Sucrose octasulfate-aluminum complex) is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus.

Chemical Structure

Molecular Weight: 2086.74

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Quality Control

Content of Al: 20.5%; Content of S: 10.5%
Cited in Nature Medicine for its top-tier quality
COA
Datasheet
SDS

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Chemical Information, Storage & Stability

Molecular Weight	2086.74	Formula	C₁₂H₅₄Al₁₆O₇₅S₈	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	54182-58-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Sucrose octasulfate-aluminum complex			Smiles	C(C1C(C(C(C(O1)OC2(C(C(C(O2)COS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])COS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al].O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.[Al].[Al].[Al].[Al].[Al].[Al].[Al].[Al]

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In vivo
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Mechanism of Action

In vitro	Sucralfate may inhibit intestinal epithelial motility by sterically interfering with adhesion to collagen I^[3]. It protects RGMl cells from acid- and pepsin-induced damage^[4].
In vivo	The protective effects of sucralfate against ARC(acute radiation colitis) may be partially due to the supression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region^[2].
References	[1] https://pubmed.ncbi.nlm.nih.gov/15561829/ [2] https://pubmed.ncbi.nlm.nih.gov/16571913/ [3] https://pubmed.ncbi.nlm.nih.gov/9018008/ [4] https://pubmed.ncbi.nlm.nih.gov/9195380/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04918758	Recruiting	Radiation Proctopathy	Manchester University NHS Foundation Trust\|National Institute for Health Research United Kingdom	July 22 2021	Not Applicable
NCT04327869	Completed	Capsule Endoscopy	Changhai Hospital	November 3 2018	--

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