Sulfabenzamide

For research use only.

Catalog No.S4576 Synonyms: Sultrin, N-Sulfanilylbenzamide

Sulfabenzamide Chemical Structure

CAS No. 127-71-9

Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.

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Biological Activity

Description Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.
In vitro

Sulfabenzamide inhibits the proliferation and increases Caspase-3 activity in T-47D cells. It dose not induce apoptosis but a minimal shift from G1 to S and G2/M phases of the cell cycle[1].

Protocol

Cell Research:[1]
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  • Cell lines: T-47D breast cancer cells
  • Concentrations: 0-20 mM
  • Incubation Time: 24, 48 and 72 h
  • Method: The MTT assay is used to evaluate the viability of T-47D cells incubated with different concentrations of sulfabenzamide (0.0-20 mM) or doxorubicin (0.0-0.6 μM) after 24, 48 and 72 h.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 55 mg/mL (199.05 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 276.31
Formula

C13H12N2O3S

CAS No. 127-71-9
Storage powder
in solvent
Synonyms Sultrin, N-Sulfanilylbenzamide
Smiles C1=CC=C(C=C1)C(=O)NS(=O)(=O)C2=CC=C(C=C2)N

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID