research use only

Segesterone acetate Estrogen/progestogen Receptor chemical

Name: Segesterone acetate
Brand: Selleck Chemicals
SKU: E0937
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E0937

Segesterone acetate (Nestoron, ST-1435) is a synthetic progestin that binds to the progesterone receptor with EC50 of 50.3 nM.

Chemical Structure

Molecular Weight: 370.48

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: E093701 DMSO]74 mg/mL]false]Ethanol]37 mg/mL]false]Water]Insoluble]false Purity: 99.96%

99.96

Related Targets	Adrenergic Receptor GPR Androgen Receptor Glucocorticoid Receptor ACE RAAS Opioid Receptor THR PGES Aromatase 5-alpha Reductase CCK receptor Mineralocorticoid Receptor GHSR SSTR TSH Receptor GNRH Receptor PGDS
Related Products	Cholesterol Endoxifen HCl G15 Licochalcone A AZD9496 PHTPP Liquiritigenin Brilanestrant (GDC-0810) Pregnenolone Estriol Lasofoxifene Tartrate Equol Genistin (Genistoside) Erteberel (LY500307) Elacestrant (RAD1901) Dihydrochloride GSK5182 Estrogen receptor modulator 1 Estrogen Receptor α Antibody [B10L16] Gypenoside XVII Imlunestrant Dihydroresveratrol (±)-Equol 27-Hydroxycholesterol Menotropin Enclomiphene Citrate Hexestrol Phospho-Estrogen Receptor α (Ser118) Antibody [L4E1] H3B-5942 Zearalenone SLU-PP-332

Chemical Information, Storage & Stability

Molecular Weight	370.48	Formula	C₂₃H₃₀O₄	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	7759-35-5	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Nestoron, ST-1435			Smiles	CC(=O)OC1(C(C)=O)C(=C)CC2C3CCC4=CC(=O)CCC4C3CCC12C

Solubility

In vitro
Batch:

DMSO : 74 mg/mL (199.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 37 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	progesterone receptor ^[1] (In the progestational assay) 50.3 nM(EC50)
References	[1] https://pubmed.ncbi.nlm.nih.gov/11108869/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03452111	Active not recruiting	Healthy\|Men\|Male Contraception	Health Decisions\|Population Council\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	October 25 2018	Phase 2
NCT02994602	Completed	Healthy Men\|Male Contraception\|Healthy Women\|Product Transference	Health Decisions\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)\|Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center\|University of Washington\|Population Council	January 2017	Phase 1
NCT00891228	Completed	Contraception	Health Decisions\|Population Council\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	May 2009	Phase 1

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):