Sulfanilamide

For research use only. Not for use in humans.

Catalog No.S1685

Sulfanilamide Chemical Structure

Molecular Weight(MW): 172.2

Sulfanilamide (Sulphanilamide) is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.

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10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Biological Activity

Description Sulfanilamide (Sulphanilamide) is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
Targets
dihydropteroate synthetase [1]
320 μM
In vitro

Sulfanilamide containing the sulfonamide functional group displays inhibitory activity for dihydropteroate synthetase partially purified from Escherichia coli which normally uses para-aminobenzoic acid (PABA) for synthesizing the necessary folic acid acting as a coenzyme in the synthesis of purine, pyrimidine and other amino acids, exhibiting an IC 50 of 320 μM for dihydropteroate synthetasea and Km of 2.5 uM for PABA. [1] Sulfanilamide shows IC50 of 286.8 μg/mL for recombinant S. cerevisiae strains with wild-type FOL1 genes, but the single mutation 55Trp to 55Ala or 57Pro to 57Ser within the putative active site of the fungal DHPS confers resistance to Sulfanilamide with IC50 of >800 μg/mL. [2] Sulfanilamide moderately inhibits the growth of bacterial cells harboring plasmodium falciparum pKOS-pfPPPK-DHPS (His) with IC50 of 380 uM. [3]

In vivo Administration of Sulfanilamide with the dosage of 100 mg/kg/day is effective in the prevention of P. carinii infection in the immunosuppressed rat model. When the dosage of sulfaguanidine and Sulfanilamide reduced to 10 mg/kg/day, breakthrough P. carinii infection occurs in the rats. [4]

Protocol

Animal Research:[4]
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  • Animal Models: Male Sprague-Dawley rats
  • Formulation: Thoroughly mixed into the daily ration of pulverized food and compounded into pellets.
  • Dosages: 100 mg/kg
  • Administration: Orally taken every day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 34 mg/mL (197.44 mM)
Ethanol 17 mg/mL (98.72 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 172.2
Formula

C6H8N2O2S

CAS No. 63-74-1
Storage powder
in solvent
Synonyms N/A
Smiles NC1=CC=C(C=C1)[S](N)(=O)=O

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID