Sarilumab

Catalog No.A2011 Synonyms: SAR153191, REGN88 Non-humanized mouse model applicable

For research use only. Not for use in humans.

Sarilumab is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.

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Biological Activity

Description Sarilumab is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.
Targets
IL-6R (human) [1]
()
IL-6R (monkey) [1]
()
61.9 pM(Kd) 71.9 pM(Kd)
In vitro

Sarilumab (SAR153191/REGN88) is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity thereby blocking cis and trans IL-6-mediated inflammatory signalling cascade, and with no evidence of complement-dependent or antibody-dependent cell-mediated cytotoxicity[1]. Sarilumab provides partial growth inhibition of a subset of the tumor cell lines tested, e.g., DU145 (prostate), Calu3 (lung) and A549 (lung)[2]. Sarilumab bound with high affinity to recombinant monomeric human and monkey IL-6 receptor with a KD value of 61.9 pM and 71.9 pM, respectively. The binding affinity of sarilumab to the dimeric human IL-6 receptor Fc-fusion is 12.8 pM. sarilumab is specific to human and monkey IL-6 receptor and does not cross-react with mouse IL-6R[3].

In vivo Sarilumab has been shown in preclinical studies to inhibit IL-6 signalling in a dose-dependent manner[1].

Protocol

Product Details

Formulation PBS buffer, pH 7.2
Isotype Human IgG
Source CHO cells
Storage Store at -80°C and avoid freeze-thaw cycles.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID