Home Biosimilar Antibodies Immunology & Inflammation IL Receptor Sarilumab (anti-IL-6Rα)
For research use only. Not for use in humans.

Sarilumab (anti-IL-6Rα)

Synonyms: erbB-2， CD340

Sarilumab (anti-IL-6Rα) is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.

Sarilumab (anti-IL-6Rα) Chemical Structure

Click to purchase the isotype control of Sarilumab (anti-IL-6Rα)

6 Citations

The Nobel Prize

17 Nobel Prize winners have used Selleck products

Shimon Sakaguchi

Nature Communications 2025,16, Article number:1325

David Baker

Dev Cell 2023, 58(20):2163-2180.e9.

David Julius

Cell 2017, 185-198.e16

Michael Houghton

Cell Chem Biol, 2020, 27(7):780-792.e5

Charles M. Rice

Cell 2018, 172(3):423-438.e25

Quality Control

Batch: A201101 Purity: 98.05% Protein concentration: 5.0 mg/ml Endotoxin Level: ≤1 EU/mg
98.05

Specificity

Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Sarilumab (anti-IL-6Rα) is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.
Features
Human IgG1
Targets/IC50/Ki
IL-6R (human)
61.9 pM(Kd)
IL-6R (monkey)
71.9 pM(Kd)
In vitro

Sarilumab can reverse IL-6 enhanced colony formation in HCC cells under sorafenib or regorafenib treatment.
Cell Research

Cells were treated with drugs for 36 h. The soluble form of IL-6Rα in cell culture supernatants was measured with a human IL-6Rα ELISA kit according to the manufacturer’s instructions. Plates were measured on a microplate reader at a wavelength of 450 nm.
In vivo

Sarilumab has been shown in preclinical studies to inhibit IL-6 signalling in a dose-dependent manner.
References

Product Details

CAS No. 1189541-98-7
Isotype Human IgG1
Source CHO cells
Sterility 0.2 μM filtered
Formulation PBS buffer, pH 7.2
Storage
(From the date of receipt)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01042379 RECRUITING Drug: Standard Therapy|Drug: AMG 386 with or without Trastuz Breast Neoplasms; Breast Cancer; Breast Tumors; Angiosarcoma; TNBC - Triple-Negative Breast Cancer; HER2-positive Breast Cancer; HER2-negative Breast Cancer; Hormone Receptor Positive Tumor; Hormone Receptor Negative Tumor; Early-stage Breast Cancer; Locally Advanced Breast Cancer QuantumLeap Healthcare Collaborative 2010-03-01 PHASE2
NCT07154290 RECRUITING Drug: Ubamatamab|Drug: Marlotamig|Drug: Sarilumab Non Small Cell Lung Cancer; Advanced Non Small Cell Lung Cancer; Metastatic Non Small Cell Lung Cancer; Carcinoma Non Small Cell Lung Regeneron Pharmaceuticals 2026-03-18 PHASE2
NCT07286214 RECRUITING Drug: Sarilumab|Drug: Sarilumab|Drug: Placebo Polymyalgia Rheumatica Sanofi 2026-05-12 PHASE4
NCT07704580 RECRUITING Drug: Sarilumab, SAR153191 SC|Drug: Sarilumab, SAR153191 IV Rheumatoid Arthritis Sanofi 2026-07-02 PHASE1; PHASE2
NCT06787612 RECRUITING Drug: Ubamatamab|Drug: Bevacizumab|Drug: Cemiplimab|Drug: Fi Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer Regeneron Pharmaceuticals 2025-05-28 PHASE2
NCT07484113 NOT_YET_RECRUITING Drug: Belumosudil|Drug: Sarilumab cGVHD Stanford University 2026-09 PHASE1

(data from https://clinicaltrials.gov, updated on 2026-05-06)

Tech Support

Handling Instructions

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Frequently Asked Questions

Question 1:
How to store the antibody?

Answer:
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.