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Sevelamer Carbonate

Cat.No.S4134

Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion.
Sevelamer Carbonate Chemical Structure

Chemical Structure

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  • Binding of Phosphate: 4.89mmol/g
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Chemical Information, Storage & Stability

Molecular Weight Formula

(C3H7N.C3H5ClO)x.xCH2O3

 Storage (From the date of receipt)
CAS No. 845273-93-0 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C=CCN.C1C(O1)CCl.C(=O)(O)O

Mechanism of Action

In vitro
Sevelamer carbonate is designed as an alternative to sevelamer hydrochloride with enhanced buffering capacity. The sevelamer moiety consists of a carbon backbone with multiple amine groups, each separated from the backbone by a single carbon atom. In the intestine, Sevelamer carbonate become protonated and subsequently bind to dietary phosphorus molecules via ionic and hydrogen interactions. The result of these interactions is a decrease in phosphorus levels within the gastrointestinal tract, resulting in decreased dietary phosphorus absorption and decreased serum phosphorus levels. In addition to the effect on phosphorus levels, the polymeric amine structure of sevelamer has been shown to bind bile acids to reduces total cholesterol levels.
In vivo
Sevelamer Carbonate is able to reduce renal failure triggered inflammation and induced endotoxemia in experimental model of chronic kidney disease. Sevelamer carbonate also shows beneficial effects on renal dysfunction, secondary hyperparathyroidism and vascular calcification in rats fed with high-phosphorus diet.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01220843 Completed
Chronic Renal Failure
Centre Hospitalier Universitaire Amiens|Genzyme a Sanofi Company
 October 2010 Phase 3
NCT01191762 Completed
Hyperparathyroidism|Chronic Kidney Disease
Kenneth R. Phelps M.D.|Genzyme a Sanofi Company|Phelps Kenneth R. M.D.
 April 2010 Phase 3
NCT01011699 Terminated
Chronic Renal Failure|Hemodialysis
Centre Hospitalier Universitaire Amiens
 January 2010 Phase 3
NCT00853242 Completed
Kidney Failure Chronic
Genzyme a Sanofi Company|Sanofi
 February 2009 Phase 2

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