Home GPCR & G Protein Glucagon Receptor agonist Semaglutide

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Semaglutide GLP-1 Receptor agonist

Cat.No.S9697

Semaglutide is an oral agonist of glucagon-like peptide-1 receptor (GLP1R), used for treating type 2 diabetes and obesity by enhancing insulin secretion, reducing glucagon levels, and promoting weight loss. It is available in subcutaneous and oral formulations.
Semaglutide Glucagon Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 4113.58

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Quality Control

Batch: Purity: 99.95%
99.95

Solubility

In vitro
Batch:

4-Methylpyridine<1 : 4 mg/mL

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 4113.58 Formula Storage (From the date of receipt) 3 years -20°C powder
CAS No. 910463-68-2 -- Storage of Stock Solutions

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC50/Ki
GLP-1 receptor
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-19)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07772960 NOT_YET_RECRUITING
Alcohol Use Disorder (AUD); Obesity (BMI Equal to or >30)
Yale University
 2026-10-01 PHASE1
NCT06977438 NOT_YET_RECRUITING
Obesity, Childhood
University of Minnesota
 2026-10-01 PHASE4
NCT07731256 NOT_YET_RECRUITING
Lower Back Pain; Obesity (BMI>30); Chronic Lower Back Pain; glp1 Agonist
Washington University School of Medicine
 2027-02-01 PHASE2
NCT06934655 RECRUITING
Pediatric Obesity; Metabolic and Bariatric Surgery; Semaglutide
Children's Hospital Los Angeles
 2026-09-01 PHASE3
NCT07135245 NOT_YET_RECRUITING
Alzheimer Disease (AD)
Rune Skovgaard Rasmussen
 2026-01-01 PHASE2
NCT07090343 NOT_YET_RECRUITING
Aortic Stenosis; Heart Failure
Leiden University Medical Center
 2026-04-01 PHASE3

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