Staurosporine (AM-2282)

Name: Staurosporine (AM-2282)
Brand: Selleck Chemicals
SKU: S1421
Rating: 5 (102 reviews)

For research use only.

Catalog No.S1421 Synonyms: Antibiotic AM-2282, STS

102 publications

Staurosporine (AM-2282) Chemical Structure

CAS No. 62996-74-1

Staurosporine (AM-2282, Antibiotic AM-2282, STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.

Selleck's Staurosporine (AM-2282) has been cited by 102 publications

Nature, 2021, 10.1038/s41586-021-04009-w

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Cell, 2020, 182(3):685-712.e19

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Cancer Discov, 2019, 10.1158/2159-8290.CD-19-0270

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Gastroenterology, 2017, 153(5):1429-1443

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Nat Commun, 2021, 12(1):3636

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Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00196-X

PubMed: 34562639 ( click the link to review the publication )

Cell Chem Biol, 2021, S2451-9456(21)00475-X

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Cell Chem Biol, 2021, S2451-9456(21)00303-2

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Front Cell Dev Biol, 2021, 9:698679

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Eur J Med Chem, 2021, 211:113003

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Cell Oncol (Dordr), 2021, 10.1007/s13402-021-00632-x

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J Cell Physiol, 2021, 10.1002/jcp.30443

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Mol Cancer Res, 2021, molcanres.0342.2021

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Molecules, 2021, 26(15)4549

PubMed: 34361708 ( click the link to review the publication )

Biochem Biophys Res Commun, 2021, 567:92-98

PubMed: 34146907 ( click the link to review the publication )

STAR Protoc, 2021, 2(2):100391

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Cell Rep, 2021, 34(8):108767

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J Immunother Cancer, 2021, 9(2)e001906

PubMed: 33526609 ( click the link to review the publication )

EMBO J, 2020, 39(5):e102608

PubMed: 31930741 ( click the link to review the publication )

Genes Dev, 2020, 34(7-8):526-543

PubMed: 32079652 ( click the link to review the publication )

Cell Rep, 2020, 10;30(10):3411-3423 e7

PubMed: 32160546 ( click the link to review the publication )

Cell Rep, 2020, 30(11):3864-3874

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EBioMedicine, 2020, 51:102585

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Sci Signal, 2020, 13(623)

PubMed: 32184287 ( click the link to review the publication )
Cancers (Basel), 2020, 12(9)E2668

PubMed: 32962010 ( click the link to review the publication )

Cancers (Basel), 2020, 10;12(6):E1523

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Anal Chem, 2020, 92(1):1363-1371

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Anal Chem, 2020, 10.1021/acs.analchem.0c02756

PubMed: 32933243 ( click the link to review the publication )

FASEB J, 2020, 34(1):1122-1135

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Eur J Med Chem, 2020, 193:112232

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Nephrol Dial Transplant, 2020, gfaa290

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Eur J Immunol, 2020, 10.1002/eji.202048905

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Int J Mol Sci, 2020, 18;21(8):2825

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Sci Rep, 2020, 10(1):18677

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Sci Rep, 2020, 10(1):931

PubMed: 31969633 ( click the link to review the publication )

Molecules, 2020, 25(18)E4318

PubMed: 32967084 ( click the link to review the publication )

Eur J Pharmacol, 2020, 868:172886

PubMed: 31866407 ( click the link to review the publication )

Neoplasia, 2020, 22(10):470-483

PubMed: 32818841 ( click the link to review the publication )

Cell Res, 2020, 1-13

PubMed: 32759968 ( click the link to review the publication )

Cell Rep, 2020, 32(4):107959

PubMed: 32726624 ( click the link to review the publication )

Oncogene, 2020, 10.1038/s41388-020-1382-5

PubMed: 32651460 ( click the link to review the publication )

Mol Cancer Ther, 2020, 19(2):637-649

PubMed: 31784455 ( click the link to review the publication )

Autophagy, 2019, 10.1080/15548627

PubMed: 31251111 ( click the link to review the publication )

Autophagy, 2019, 15(2):295-311

PubMed: 30176161 ( click the link to review the publication )

Br J Pharmacol, 2019, 176(22):4388-4401

PubMed: 30270436 ( click the link to review the publication )

Ther Adv Med Oncol, 2019, 11:1758835919891567

PubMed: 31839810 ( click the link to review the publication )

FASEB J, 2019, 33(8):9062-9074

PubMed: 31180722 ( click the link to review the publication )

Nephrol Dial Transplant, 2019, 34(6):934-941

PubMed: 30189026 ( click the link to review the publication )
Int J Biol Sci, 2019, 15(4):838-846

PubMed: 30906214 ( click the link to review the publication )

Int Immunopharmacol, 2019, 66:146-153

PubMed: 30453148 ( click the link to review the publication )

Methods Mol Biol, 2019, 2054:171-183

PubMed: 31482456 ( click the link to review the publication )

J Org Chem, 2019, 10.1021/acs.joc.9b02414

PubMed: 31858795 ( click the link to review the publication )

Cell Res, 2018, 28(8):833-854

PubMed: 30030520 ( click the link to review the publication )

Nat Commun, 2018, 9(1):4846

PubMed: 30451870 ( click the link to review the publication )

Oncogene, 2018, 37(30):4122-4136

PubMed: 29706657 ( click the link to review the publication )

Oncogene, 2018, 37(11):1485-1502

PubMed: 29321664 ( click the link to review the publication )

Arch Toxicol, 2018, 92(6):2119-2135

PubMed: 29589053 ( click the link to review the publication )

Biochem Pharmacol, 2018, 150:9-23

PubMed: 29338970 ( click the link to review the publication )

Acta Pharmacol Sin, 2018, 39(12):1902-1912

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Analyst, 2018, 143(12):2908-2914

PubMed: 29808847 ( click the link to review the publication )

Mol Carcinog, 2018, 57(7):886-895

PubMed: 29566278 ( click the link to review the publication )

Phytomedicine, 2018, 40:148-157

PubMed: 29496167 ( click the link to review the publication )

Exp Cell Res, 2018, 370(1):103-115

PubMed: 29908160 ( click the link to review the publication )

Virus Res, 2018, 246:55-64

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J Child Adolesc Psychopharmacol, 2018, 28(2):117-123

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Oncotarget, 2018, 9(24):16917-16931

PubMed: 29682194 ( click the link to review the publication )

Oncotarget, 2018, 9(89):35962-35973

PubMed: 30542510 ( click the link to review the publication )

Oncotarget, 2018, 9(32):22254-22268

PubMed: 29854276 ( click the link to review the publication )

Nat Commun, 2017, 1;8(1):1232

PubMed: 29089541 ( click the link to review the publication )

EMBO J, 2017, 36(2):202-212

PubMed: 27852626 ( click the link to review the publication )

Cell Rep, 2017, 20(7):1692-1704

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Anal Chem, 2017, 89(3):1892-1899

PubMed: 28208281 ( click the link to review the publication )
Mol Cancer Ther, 2017, 16(1):57-67

PubMed: 27760835 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(10):2201-2214

PubMed: 28619755 ( click the link to review the publication )

J Virol, 2017, 91(23)

PubMed: 28904196 ( click the link to review the publication )

Acta Pharmacol Sin, 2017, 38(12):1632-1641

PubMed: 28713162 ( click the link to review the publication )

J Agric Food Chem, 2017, 65(31):6625-6637

PubMed: 28697598 ( click the link to review the publication )

Virology, 2017, 505:91-101

PubMed: 28235685 ( click the link to review the publication )

SLAS Discov, 2017, 22(5):507-515

PubMed: 28324660 ( click the link to review the publication )

Oncotarget, 2017, 8(42):71512-71519

PubMed: 29069723 ( click the link to review the publication )

Eur J Med Chem, 2016, 124:583-607

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Mol Pharm, 2016, 13(11):3724-3735

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J Cancer Res Clin Oncol, 2016, 142(11):2263-73

PubMed: 27576506 ( click the link to review the publication )

PLoS One, 2016, 11(5):e0154932

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Biochem Biophys Res Commun, 2016, 471(4):528-32

PubMed: 26879140 ( click the link to review the publication )

Exp Clin Endocrinol Diabetes, 2016, 1427:419-30

PubMed: 26849668 ( click the link to review the publication )

Oncotarget, 2016, 7(46):74987-74999

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Oncotarget, 2016, 7(27):41488-41504

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Methods Mol Biol, 2016, 1427:419-30

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Mol Cancer, 2015, 14:114

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Mol Cancer, 2015, 14:59

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J Exp Clin Cancer Res, 2015, 34:69

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Cancer Cell Int, 2015, 15:97

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PLoS One, 2015, 10(3):e0119715

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PLoS One, 2015, 10(7):e0134306

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Cancer Res, 2014, 74(23):7090-102

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Cell Rep, 2014, 8(4):1037-48

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Cell Commun Signal, 2013, 11:76

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Am J Physiol Cell Physiol, 2013, 304(9):C895-904

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J Biomol Screen, 2013, 18(4):388-99

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PLoS One, 2012, 7(6):e39679

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J Biomol Screen, 2012, 17(6):813-21

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Purity & Quality Control

Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors

Biological Activity

Description

Targets

PKCα ^[1] (Cell-free assay)	c-Fgr ^[2] (Cell-free assay)	phosphorylase kinase ^[2] (Cell-free assay)	PKCη ^[1] (Cell-free assay)	PKCγ ^[1] (Cell-free assay)	View More
2 nM	2 nM	3 nM	4 nM	5 nM	View More

In vitro

Staurosporine, a microbial alkaloid, significantly inhibits protein kinase C from rat brain with IC50 of 2.7 nM. Staurosporine displays strong inhibitory effect against HeLa S3 cells with IC50 of 4 nM. ^[1] Staurosporine also inhibits a variety of other protein kinases, including PKA, PKG, phosphorylase kinase, S6 kinase, Myosin light chain kinase (MLCK), CAM PKII, cdc2, v-Src, Lyn, c-Fgr, and Syk with IC50 of 15 nM, 18 nM, 3 nM, 5 nM, 21 nM, 20 nM, 9 nM, 6 nM, 20 nM, 2 nM, and 16 nM, respectively. ^[2] Staurosporine (1 μM) induces >90% apoptosis in PC12 cells. Consistently, Staurosporine treatment induces a rapid and prolonged elevation of intracellular free calcium levels [Ca²⁺]_i, accumulation of mitochondrial reactive oxygen species (ROS), and subsequent mitochondrial dysfunction. ^[3] The apoptosis of MCF7 cells induced by Staurosporine can be enhanced by the expression of functional caspase-3 via caspase-8 activation and Bid cleavage. ^[4] Staurosporine treatment at 1 μM only partially inhibits IL-3-stimulated Bcl2 phosphorylation but completely blocks PKC-mediated Bcl2 phosphorylation. ^[5] Staurosporine induces apoptosis of human foreskin fibroblasts AG-1518, depending on the lysosomal cathepsins D mediated cytochrome c release and caspase activation. ^[6] In addition to activating the classical mitochondrial apoptosis pathway, Staurosporine triggers a novel intrinsic apoptosis pathway, relying on the activation of caspase-9 in the absence of Apaf-1. ^[7]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
human colon carcinoma cell line HCT116	MkfqSpVv[3Srb36gZZN{[Xl?			MXnDc45k\W62cnH0bY9vKHKncYXpdoVlKG[xcjDndo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDjc4xwdiClYYLjbY5wdWFiY3XscEBtcW6nIFjDWFEyPixiSVO1NF03KG6PLh?=	NV;q[HR1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1N\|c{PDVpPkG1OVM4OzR3PD;hQi=>
human PBMC	NU\2W2ZkTnWwY4Tpc44h[XO\|YYm=		MnLSNlQhcA>?	M{fkWHN2eHC{ZYPzbY9vKG:oIFnMNkBxem:mdXP0bY9vKGmwIHj1cYFvKFCETVOgZYZ1\XJiMkSgbJJ{KGK7IFXMTXNCNCCLQ{WwQVE3KG6PLh?=	Mlv6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3OEWwOFYoRjF6NUi1NFQ3RC:jPh?=
endothelial cells	Mn\4SpVv[3Srb36gZZN{[Xl?			MmnsSYZn\WO2aY\lJIRwe2ViYXfhbY5{fCCybHHzcYlvd2enbjDhZ5RqfmG2b4KgZYN1cX[rdImgd5RqdXWuYYTl[EBjgSCyaH;yZo9tKGW\|dHXyJIlvKGWwZH;0bIVtcWGuIHPlcIx{NCCHREWwJF0hPy53IN88UU4>	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85PzB7MEm1K\|45PzB7MEm1QE9iRg>?
Sf9 insect cells	MmLuSpVv[3Srb36gZZN{[Xl?			NETwT2lKdmirYnn0bY9vKG:oIIDyc5RmcW5ia3nuZZNmKENqMUqxcYl5fHW{ZTDv[kBRU0NiYXzwbIEhLiCkZYThLUBmgHC{ZYPz[YQhcW5iU3[5JIlve2WldDDj[YxteyxiSVO1NEA:KDBwMEKg{txONg>?	NUP2bFJQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUi3N\|YxPSd-OUi3N\|YxPTxxYU6=
LoVo cells	NVuxOVBVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=			NXTHWG8ySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubDDsbY5mKCiOb2\vJINmdGy\|KTD1d4lv\yCPVGSgZZN{[XluIFnDOVAhRSByLkCwNUDPxE1w	NFP1bZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUW5NVUxPSd-MUG1PVE2ODV:L3G+
umbilical vein endothelial cells	MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?			MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKHWvYnnsbYNidCC4ZXnuJIVv\G:2aHXsbYFtKGOnbHzzJEhJXV[HQ4OpJJV{cW6pIF3UWEBie3OjeTygTWM2OCB;IECuNFA1KM7:TT6=	M1XIPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNUmxOVA2Lz5zMUW5NVUxPTxxYU6=
ST-486 cells	MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?			MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHL1dotqfCCueX3wbI9u[SClZXzsJIxqdmViKGPUMVQ5PiClZXzsd{khfXOrbnegUXRVKGG\|c3H5MEBKSzVyIE2gNE4xODdizszNMi=>	M3LrVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNUmxOVA2Lz5zMUW5NVUxPTxxYU6=
DLD-1 cells	MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?			MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKGOxbH;uJINidmOncjDj[YxtKGyrbnWgLGRNTC1zIHPlcIx{MSC3c3nu[{BOXFRiYYPzZZktKEmFNUCgQUAxNjByOTFOwG0v	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTV7MUWwOUc,OTF3OUG1NFU9N2F-
HEK293 cells	MXLGeY5kfGmxbjDhd5NigQ>?			Ml[xTY5pcWKrdHnvckBw\iCSS1OtZoV1[SCLSTDt[YRq[XSnZDDJUE05KHKnbHXhd4Uh\nKxbTDISWszQTNiY3XscJMh[nliRVzJV2EtKEmFNUCgQUAxNjB5NzFOwG0v	NF\LNok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkm0NVM{OSd-MUK5OFE{OzF:L3G+
P19 cells	M{\INGZ2dmO2aX;uJIF{e2G7			MoW2TY5pcWKrdHnvckBw\iCSbHH0[YxmfC2mZYLpeoVlKGe{b4f0bEBn[WO2b4KgdoVk\XC2b4KgbY4hWDF7IHPlcIx{NCCLQ{WwJF0hOC5yMEKg{txONg>?	M2W1ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{exOFE6Lz5zNUe3NVQyQTxxYU6=
P19 cells	Mkj6SpVv[3Srb36gZZN{[Xl?			MkLaTY5pcWKrdHnvckBw\iCSbHH0[YxmfC2mZYLpeoVlKGe{b4f0bEBn[WO2b4KgdoVk\XC2b4KgbY4hWDF7IHPlcIx{NCCLQ{WwJF0hOC5yMEKg{txONg>?	M3TuSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{exOFE6Lz5zNUe3NVQyQTxxYU6=
P19 cells	M4HmPWZ2dmO2aX;uJIF{e2G7			NGDxbVlKdmirYnn0bY9vKG:oIGDyc5RmcW5iS3nuZZNmKEFiaX6gVFE6KGOnbHzzMEBKSzVyIE2gNE4xODRizszNMi=>	NVPpdVdLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3O\|E1OTlpPkG1O\|cyPDF7PD;hQi=>
P19 cells	NHWwVmVHfW6ldHnvckBie3OjeR?=			MmTSTY5pcWKrdHnvckBw\iCFYXzjbZVuN2OjbH3v[JVtcW5vZHXw[Y5l\W62IIDyc5RmcW5ia3nuZZNmKHS7cHWgTWkhcW5iUEG5JINmdGy\|LDDJR\|UxKD1iMD6wNFYh\|ryPLh?=	Mne1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5N{G0NVkoRjF3N{exOFE6RC:jPh?=
P19 cells	MkHmSpVv[3Srb36gZZN{[Xl?			MUDJcohq[mm2aX;uJI9nKEO7Y3zpck1l\XCnbnTlcpQhc2mwYYPlJFEhcW5iUEG5JINmdGy\|LDDJR\|UxKD1iMD6wNFgh\|ryPLh?=	NX;uWXlPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3O\|E1OTlpPkG1O\|cyPDF7PD;hQi=>
P19 cells	MUHGeY5kfGmxbjDhd5NigQ>?			M3\rRmlvcGmkaYTpc44hd2ZiVnHzZ5Vt[XJiZX7kc5Rp\WyrYXyg[5Jwf3SqIH\hZ5RweiC{ZXPldJRweiCrbjDQNVkh[2WubIOsJGlEPTBiPTCwMlAyPCEQvF2u	M1vHZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{exOFE6Lz5zNUe3NVQyQTxxYU6=
HEK293 cells	NH\nN3lHfW6ldHnvckBie3OjeR?=			NYjJblE4UW6qaXLpeIlwdiCxZjDJUE05KHKnbHXhd4Uh[nliSFXLNlk{KGOnbHzzJIV5eHKnc4PpcochWEuFLXLleIEzNCCLQ{WwJF0hOC5yN{eg{txONg>?	M1KyZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{exOFE6Lz5zNUe3NVQyQTxxYU6=
P19 cells	NX:1[\|A6TnWwY4Tpc44h[XO\|YYm=			M33hR2lvcGmkaYTpc44hd2ZiSX7zeYxqdiC{ZXPldJRweiCtaX7hd4UhcW5iUEG5JINmdGy\|LDDJR\|UxKD1iMD6yJO69VS5?	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd5MUSxPUc,OTV5N{G0NVk9N2F-
P19 cells	NVHmemZJTnWwY4Tpc44h[XO\|YYm=			MojmTY5pcWKrdHnvckBw\iCFYYPlbY4hc2mwYYPlJFEhcW5iUEG5JINmdGy\|LDDJR\|UxKD1iMT60JO69VS5?	M4LwflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{exOFE6Lz5zNUe3NVQyQTxxYU6=
FL5.12-Akt1 cells	MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?			MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IF\MOU4yOi2Da4SxJINmdGy\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOjlizszNMi=>	Mk\ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MEO2NlYoRjF4NECzOlI3RC:jPh?=
MiaPaCa-2 cells	MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?			MlTURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDNbYFR[UOjLUKgZ4VtdHNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNE4{PyEQvF2u	NWTiRYd7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NFM3OjZpPkG2OFA{PjJ4PD;hQi=>
FL5.12-Akt1 cells	MUDGeY5kfGmxbjDhd5NigQ>?			Mke4RYN1cX[rdImgZYdicW6\|dDDHV2s{KGmwIF\MOU4yOi2Da4SxJINmdGy\|LDDFR\|UxKD1iMD60OkDPxE1w	NWr4fXdHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NFM3OjZpPkG2OFA{PjJ4PD;hQi=>
MiaPaCa-2 cells	NFjMXYJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=			NXLpenZmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNbYFR[UOjLUKgZ4VtdHNuIFnDOVAhRSByLkO3JO69VS5?	NFPJNpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxN\|c5OCd-MU[0NVM4QDB:L3G+
FL5.12-Akt1 cells	MUHGeY5kfGmxbjDhd5NigQ>?			NXr6WXI{SWO2aY\peJkh[WejaX7zeEBIW0t\|IIDoc5NxcG:{eXzheIlwdiCrbjDGUFUvOTJvQXv0NUBk\WyuczygSWM2OCB;IECuOFYh\|ryPLh?=	M4DhfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEGzO\|gxLz5zNkSxN\|c5ODxxYU6=
Sf21 cells	NHixZoZHfW6ldHnvckBie3OjeR?=			M{n2[GlvcGmkaYTpc44hd2ZiSlHLN{BmgHC{ZYPz[YQhcW5iU3[yNUBk\WyuczygTWM2OCB;IECuNFA3KM7:TT6=	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB6OEC1PUc,OTdyOEiwOVk9N2F-
U937 cells	MkHFR5l1d3SxeHnjbZR6KGG\|c3H5			NHLlVY1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQTN5IHPlcIx{NCCLQ{WwJF0hOiEQvF2u	MoXaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyOEiwOlcoRjF5MEi4NFY4RC:jPh?=
Sf9 cells	MknVSpVv[3Srb36gZZN{[Xl?		MnL1NUBucW5?	NGS4TVZKdmirYnn0bY9vKG:oIHj1cYFvKE[7bjDlfJBz\XO\|ZXSgbY4hW2Z7IHPlcIx{KGGodHXyJFEhdWmwIHL5JGVNUVODIHnuJJBz\XOnbnPlJI9nKDFidX3vcE9NKEGWUDygTWM2OCB;IECuNFA2KM7:TT6=	M2TG[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{G1PFU{Lz5zN{OxOVg2OzxxYU6=
Sf9 cells	M3LEOGZ2dmO2aX;uJIF{e2G7		NFS3OI8zOCCvaX7z	MWfJcohq[mm2aX;uJI9nKGi3bXHuJGZ6diCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIFnfGW{IEKwJI1qdnNiYomgSWxKW0FiaX6gdJJme2WwY3Wgc4YhOSC3bX;sM2whSVSSLDDJR\|UxKD1iMD6wNVUh\|ryPLh?=	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzNzNUi1N{c,OTd\|MUW4OVM9N2F-
Sf9 cells	NF\zTWZHfW6ldHnvckBie3OjeR?=		NHq3VlcyKG2rbh?=	NVLEdoppUW6qaXLpeIlwdiCxZjDoeY1idiCIeX6g[ZhxemW\|c3XkJIlvKFOoOTDj[YxteyCjZoTldkAyKG2rbjDifUBGVEmVQTDpckBxemW\|ZX7j[UBw\iBzMDD1cY9tN0xiQWTQMEBKSzVyIE2gNE4xOzZizszNMi=>	MkPOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd\|MUW4OVMoRjF5M{G1PFU{RC:jPh?=
Sf9 cells	M1r3[2Z2dmO2aX;uJIF{e2G7		MlnYNlAhdWmwcx?=	NETwelBKdmirYnn0bY9vKG:oIHj1cYFvKE[7bjDlfJBz\XO\|ZXSgbY4hW2Z7IHPlcIx{KGGodHXyJFIxKG2rboOgZpkhTUyLU1GgbY4heHKnc3XuZ4Uhd2ZiMUCgeY1wdC:OIFHUVEwhUUN3MDC9JFAvODh\|IN88UU4>	NELNdVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{OxOVg2Oyd-MUezNVU5PTN:L3G+
Sf9 cells	MXXGeY5kfGmxbjDhd5NigQ>?		NIjHfYsyKG2rbh?=	M1rVRWlvcGmkaYTpc44hd2ZiaIXtZY4hTnmwIHX4dJJme3OnZDDpckBU\jliY3XscJMh[W[2ZYKgNUBucW5iYomgSWxKW0FiaX6gdJJme2WwY3Wgc4YhOTByIIXtc4wwVCCDVGCsJGlEPTBiPTCwMlI4KM7:TT6=	Mn7SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd\|MUW4OVMoRjF5M{G1PFU{RC:jPh?=
Sf9 cells	MWjGeY5kfGmxbjDhd5NigQ>?		NHnPfJYzOCCvaX7z	NX3RVYh7UW6qaXLpeIlwdiCxZjDoeY1idiCIeX6g[ZhxemW\|c3XkJIlvKFOoOTDj[YxteyCjZoTldkAzOCCvaX7zJIJ6KEWOSWPBJIlvKHC{ZYPlcoNmKG:oIEGwNEB2dW:uL1ygRXRRNCCLQ{WwJF0hOC53MTFOwG0v	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzNzNUi1N{c,OTd\|MUW4OVM9N2F-
A549 cells	MmLXR5l1d3SxeHnjbZR6KGG\|c3H5		NEDCcGs4OiCq	M3HGcmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JJN2dG[xcnjv[IFucW6nIFKgcYV1cG:mLDDHTVUxKD1iMD6wNFI1KM7:TT6=	NHPaR4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES4OFc4PSd-MUi0PFQ4PzV:L3G+
MDA-MB-231 cells	MYHDfZRwfG:6aXPpeJkh[XO\|YYm=		NUXkTlgyPzJiaB?=	MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSC\|dXzmc5Jpd2SjbXnu[UBDKG2ndHjv[EwhT0l3MDC9JFAvODB5MTFOwG0v	MnHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2OES3O\|UoRjF6NEi0O\|c2RC:jPh?=
HT29 cells	NV:0TXFPS3m2b4TvfIlkcXS7IHHzd4F6		NFLnXJY4OiCq	NUTIOIN5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFR{OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBu\XSqb3SsJGdKPTBiPTCwMlAyODlizszNMi=>	NIP6bms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES4OFc4PSd-MUi0PFQ4PzV:L3G+
MCF7 cells	MUHGeY5kfGmxbjDhd5NigQ>?			MkPHTY5pcWKrdHnvckBw\iCSS1GgbY4hcHWvYX6gUWNHPyClZXzsd{BjgSCjcoLhfU1j[XOnZDDmcJVwemW\|Y3XuZ4Uh[XO\|YYmsJGtqKD1iMD6wNFUh\|ryPLh?=	MmDoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4NU[zOlkoRjF6NkW2N\|Y6RC:jPh?=
MCF7 cells	MlTGSpVv[3Srb36gZZN{[Xl?			MWLJcohq[mm2aX;uJI9nKFCNQTDpckBpfW2jbjDNR2Y4KGOnbHzzJIJ6KGG{cnH5MYJie2WmIH\seY9z\XOlZX7j[UBie3OjeTygTWM2OCB;IEKg{txONg>?	MmPHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4NU[zOlkoRjF6NkW2N\|Y6RC:jPh?=
Sf9 cells	MmPBSpVv[3Srb36gZZN{[Xl?			MkXFTY5pcWKrdHnvckBw\iCqdX3hckBUgWtiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{whUUN3MDC9JFAvODB\|IN88UU4>	NUfuUZJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4NlM4QDRpPkG4PFI{Pzh2PD;hQi=>
Sf9 cells	Ml7iSpVv[3Srb36gZZN{[Xl?			MmHCTY5pcWKrdHnvckBw\iCqdX3hckBbSVB5MDDlfJBz\XO\|ZXSgbY4hW2Z7IHPlcIx{NCCLQ{WwJF0hOC5yNUOg{txONg>?	MnLhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6MkO3PFQoRjF6OEKzO\|g1RC:jPh?=
insect cells	NUK4TFVOTnWwY4Tpc44h[XO\|YYm=			NUX4UlA1UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQbY0yKGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[nliSGTSSkwhUUN3MDC9JFAvODFizszNMi=>	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF5OUC3Okc,OTlzN{mwO\|Y9N2F-
HT-29 cells	NFPzUVhCeG:ydH;zbZMh[XO\|YYm=		NY\pd29VOiCq	NWHrblNmUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDIWE0zQSClZXzsd{Bie3Onc4Pl[EBieyClaHHu[4UhcW5ibXn0c4Npd26mcnnhcEB1emGwc33lcYJz[W6nIIDveIVvfGmjbDDh[pRmeiB{IHjyd{BjgSCMQ{Ggd5RicW6rbnegZoF{\WRiZnz1c5Jme2OnbnPlJIF{e2G7LDDFSFUxKD1iMD6wNFI3KM7:TT6=	NX:1WI1oRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0NlIzODZpPkG5OFIzOjB4PD;hQi=>
insect Sf21 cells	NXLlRoN7TnWwY4Tpc44h[XO\|YYm=			NVyyPXh7UW6qaXLpeIlwdiCxZjDKRWs{KGW6cILld5Nm\CCrbjDpcpNm[3RiU3[yNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHLpc5RqdnmuYYTl[EB{fWK\|dILheIUheGixc4Doc5J6dGG2aX;uMEBKSzVyIE2gNE4xODZizszNMi=>	MnvhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2MkeyNFMoRjF7NEK3NlA{RC:jPh?=
Jurkat cells	M2\ifGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7			NHy0UoVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGpCUzNiZYjwdoV{e2mwZzDJUFIue3SrbYXsZZRm\CCqdX3hckBLfXKtYYSgZ4VtdHNuIFnDOVAhRSByLkC3NUDPxE1w	NGW2Xo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUSyO\|IxOyd-MUm0NlczODN:L3G+
Jurkat cells	MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?			NV\J[IZuSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBLSUt\|IHX4dJJme3OrbnegbJVu[W5icnXzeIlv\yCMdYLrZZQh[2WubIOsJGlEPTBiPTCwMlMyOSEQvF2u	M3HXc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NEK3NlA{Lz5zOUSyO\|IxOzxxYU6=
HUE cells	M{DQOmZ2dmO2aX;uJIF{e2G7		M3npb\|kxKG2rboO=	Mnz2TY5pcWKrdHnvckBw\iCYRVfGVlIhcW5iSGXFJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiVlXHSk1qdmS3Y3XkJIF2fG:yaH;zdIhwenmuYYTpc44hfHKnYYTl[EBnd3JiOUCgcYlveyCkZX\vdoUhXkWJRjDjbIFtdGWwZ3WgZpkhTUyLU1GsJGlEPTBiPTCwMlA4KM7:TT6=	M1riTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUewNVY{Lz5{MEG3NFE3OzxxYU6=
Sf9 cells	MnzISpVv[3Srb36gZZN{[Xl?		M3\ZWVYxKG2rboO=	M3P3b2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiR2PUMYZ2e2WmIF7JT{BmgHC{ZYPz[YQhcW5iU3[5JINmdGy\|IHHmeIVzKDZyIH3pcpMh[nlicnHkbY9u\XS{aXOgdJJwfGWrbjDrbY5ie2ViYYPzZZktKEmFNUCgQUAzNjNizszNMi=>	NX2weVhbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1PFA2PTJpPkKwOVgxPTV{PD;hQi=>
Sf21 cells	NFHiU3hHfW6ldHnvckBie3OjeR?=	M1u1SFMxKHWP		M1Wx[GlvcGmkaYTpc44hd2ZiaIXtZY4hS0iNMjDrbY5ie2ViZYjwdoV{e2WmIHnuJIlve2WldDDT[lIyKGOnbHzzJJV{cW6pIIDoc5NxcG9vQ2LFRpRq\GViYYOgd5Vje3S{YYTlJIF1KDNyIIXNMEBKSzVyIE2gNE4xOjdizszNMi=>	NV;3cmh[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN\|Q4QTZpPkKxN\|M1Pzl4PD;hQi=>
Sf21 cells	NGDTUGpHfW6ldHnvckBie3OjeR?=	MVyzNEB2VQ>?		MmLPTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCLS1utZYxxcGFiZYjwdoV{e2WmIHnuJIlve2WldDDT[lIyKGOnbHzzJJV{cW6pIIDoc5NxcG9vVXzp[4h1NUmtYYDwZWIu[WyyaHGgZZMhe3Wkc4TyZZRmKGG2IEOwJJVONCCLQ{WwJF0hOC5yM{mg{txONg>?	NFXmVmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzOFc6Pid-MkGzN\|Q4QTZ:L3G+
Sf21 cells	M{\2XmZ2dmO2aX;uJIF{e2G7	NUC2UoVSOzBidV2=		M3rVN2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSVvLMYJmfGFiZYjwdoV{e2WmIHnuJIlve2WldDDT[lIyKGOnbHzzJJV{cW6pIIDoc5NxcG9vVXzp[4h1NUmtYYDwZWIu[WyyaHGgZZMhe3Wkc4TyZZRmKGG2IEOwJJVONCCLQ{WwJF0hOC52OTFOwG0v	MnPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF\|M{S3PVYoRjJzM{O0O\|k3RC:jPh?=
HeLa cells	MofnR5l1d3SxeHnjbZR6KGG\|c3H5		M4jHWFQ5KGh?	NFnGOGxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjByMECwOEDPxE1w	M4O4cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{i4NVkyLz5{MUO4PFE6OTxxYU6=
MCF7 cells	M3LMcmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NH\KVGQ1QCCq	NX7VOpR6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yNTFOwG0v	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN6OEG5NUc,OjF\|OEixPVE9N2F-
HT-29 cells	M3z6SWZ2dmO2aX;uJIF{e2G7		NEX6d40zKGh?	M17nWmVn\mWldDDvckBucXSxY3jvcoRzcWGuIH3lcYJz[W6nIIDveIVvfGmjbDDpckBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjCyJIhzeyC3c3nu[{BLSy1zIIP0ZYlvcW6pIHL5JIZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFAvODB{IN88UU4>	M4m4dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEK4N\|c2Lz5{MUSyPFM4PTxxYU6=
HeLa cells	Mn\xR5l1d3SxeHnjbZR6KGG\|c3H5		MnH1OFghcA>?	MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlAxODByNDFOwG0v	MljpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2OEi2OVUoRjJzNEi4OlU2RC:jPh?=
MCF7 cells	MkK2R5l1d3SxeHnjbZR6KGG\|c3H5		M2DQXlQ5KGh?	NWrMSmR6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yNTFOwG0v	NXTPbItQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0PFg3PTVpPkKxOFg5PjV3PD;hQi=>
HT-29 cells	NELGdFdHfW6ldHnvckBie3OjeR?=			NX;jc3FYUW6qaXLpeIlwdiCxZjDtbZRw[2ixbnTybYFtKG2nbXLyZY5mKHCxdHXueIlidCCrbjDoeY1idiCKVD2yPUBk\WyuczD1d4lv\yCMQ{Gg[JlmKHO2YXnubY5oKGK7IH\seY9z\XOlZX7j[UBxdGG2ZTDy[YFl\XJiYYPzZZktKEmFNUCgQUAxNjByMkWg{txONg>?	NV3uT3NYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1NVMzQTNpPkKxOVE{Ojl\|PD;hQi=>
SF268 cells	M2DaXmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NYToT3dZPDhiaB?=	MkixR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2YzPjhiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODR2IN88UU4>	NEnTc2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWxN\|I6PCd-MkG1NVMzQTR:L3G+
CHOK1 cells	NFv2dlFEgXSxdH;4bYNqfHliYYPzZZk>		NWf1e5ZOPDhiaB?=	M{G2OWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNJV0tzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjF\|IN88UU4>	NHK0bIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWxN\|I6PCd-MkG1NVMzQTR:L3G+
H460 cells	NE\rb3lEgXSxdH;4bYNqfHliYYPzZZk>		MnW0OFghcA>?	NFntdHFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJPDZyIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUA{NjZizszNMi=>	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTVzM{K5OEc,OjF3MUOyPVQ9N2F-
HT-29 cells	NHTnSmNEgXSxdH;4bYNqfHliYYPzZZk>		MXe0PEBp	M1XpVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUA{NjZizszNMi=>	M{XrSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUGzNlk1Lz5{MUWxN\|I6PDxxYU6=
MCF7 cells	Mnv3R5l1d3SxeHnjbZR6KGG\|c3H5		MYK0PEBp	MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO\|YYmsJGdKPTBiPTCxNUDPxE1w	MnPkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3MUOyPVQoRjJzNUGzNlk1RC:jPh?=
SW1116 cells	NIfWNohHfW6ldHnvckBie3OjeR?=		MUCyOEBp	NYTNfYhJUW6qaXLpeIlwdiCxZjD0[YxwdWW{YYPlJIlvKGi3bXHuJHNYOTFzNjDj[YxteyCjZoTldkAzPCCqcoOgZpkhXFKDUD3QR3IuTUyLU1GgZZN{[XluIFnDOVAhRSB6LkOyJO69VS5?	NGjwR5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2NlUzOyd-MkG5OlI2OjN:L3G+
HT-29 cells	MlTkRZBweHSxc3nzJIF{e2G7		MnLVNkBp	M3m5W2lv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iSGStNlkh[2WubIOgZZN{\XO\|ZXSgdoVlfWO2aX;uJI9nKG2rdH;jbI9v\HKrYXygcYVu[nKjbnWgdI91\W62aXHsJIFnfGW{IEKgbJJ{KGK7IIXzbY5oKEqFMTDzeIFqdmmwZzDifUBndHWxcnXzZ4Vv[2ViY3XscE1j[XOnZDDhd5NigSxiRVS1NEA:KDBwMECyOkDPxE1w	NXjLOZZbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5O\|MyODFpPkKxPVc{OTBzPD;hQi=>
LoVo cells	Ml\iRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		MojYOFghfG9iN{KgbC=>	M3ToZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTH;Wc{Bk\WyuczDh[pRmeiB2ODD0c{A4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMEGg{txONg>?	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF6MkmyPUc,OjJzOEK5Nlk9N2F-
ST486 cells	MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MXG0PEB1dyB5MjDo	Ml7JRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCVVES4OkBk\WyuczDh[pRmeiB2ODD0c{A4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMEeg{txONg>?	M4PWWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUiyPVI6Lz5{MkG4NlkzQTxxYU6=
DLD1 cells	MVnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		NGHJU4M1QCC2bzC3NkBp	MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESOREGgZ4VtdHNiYX\0[ZIhPDhidH:gO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODB7IN88UU4>	NGXuOG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG4NlkzQSd-MkKxPFI6Ojl:L3G+
B16F10 cells	NIKxO5VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		M{Szb\|Q5KGh?	MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEJzNl[xNEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMj64NkDPxE1w	MoiwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3MEOzOlQoRjJ{NUCzN\|Y1RC:jPh?=
MCF7 cells	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		M{X3PVQ5KGh?	MmThRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPQ1[3JINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB\|LkC3JO69VS5?	NGqwNo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWwN\|M3PCd-MkK1NFM{PjR:L3G+
A431 cells	NGf5W4hEgXSxdH;4bYNqfHliYYPzZZk>		NUXDR\|UzOjRiaB?=	MkK5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{Bi\nSncjCyOEBpenNidYPpcochSW6wZYjpckBX\U[LVFOvdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZzDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB5IN88UU4>	NXriSpB7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OFExPTFpPkKyOVQyODVzPD;hQi=>
MCF7 cells	MnHhR5l1d3SxeHnjbZR6KGG\|c3H5		NH7HeoszPCCq	NGL1R5REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFI1KGi{czD1d4lv\yCDbn7lfIlvKF[nRlnUR{9xem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMUig{txONg>?	MoDHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3NEGwOVEoRjJ{NUSxNFUyRC:jPh?=
BJ cells	NWL1NY4zS3m2b4TvfIlkcXS7IHHzd4F6		NW\qeJRVPzJiaB?=	MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCTkBk\WyuczDh[pRmeiB5MjDodpMh[nliQ3HsZ4VqdiCDTTDhd5NigSxiSVO1NEA:KDBwMECyJO69VS5?	NX[4SoRmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NlExQDFpPkKyPVIyODhzPD;hQi=>
CEM cells	NVj2bpg2S3m2b4TvfIlkcXS7IHHzd4F6		M4LNbVczKGh?	MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDSW0h[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPhcINmcW5iQV2gZZN{[XluIFnDOVAhRSByLkCyN{DPxE1w	NUDE[JFURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NlExQDFpPkKyPVIyODhzPD;hQi=>
MCF7 cells	MX3DfZRwfG:6aXPpeJkh[XO\|YYm=		MWq3NkBp	NEj1OmVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBE[WylZXnuJGFOKGG\|c3H5MEBKSzVyIE2gNE4xPjRizszNMi=>	M165[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUKxNFgyLz5{MkmyNVA5OTxxYU6=
HeLa cells	NHjzdnVEgXSxdH;4bYNqfHliYYPzZZk>		MUW3NkBp	M{\weGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JGNidGOnaX6gRW0h[XO\|YYmsJGlEPTBiPTCwMlE4PSEQvF2u	M2rqOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUKxNFgyLz5{MkmyNVA5OTxxYU6=
HepG2 cells	NVK2[mZiTnWwY4Tpc44h[XO\|YYm=		NWDCRWkzOjRiaB?=	MW\Jcohq[mm2aX;uJI9nKHSnbH;t[ZJie2ViaX6gbJVu[W5iSHXwS\|Ih[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IGTSRXAuWEOULVXMTXNCKGG\|c3H5MEBKSzVyIE2gOE4yPCEQvF2u	NHjSWXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxPFA6Pid-MkOwNVgxQTZ:L3G+
SW1116 cells	NYDDdFJpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		MUe0PEBp	NVy0c\|R4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW\|EyOTZiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCvZYToc4QtKEmFNUCgQUA1Njl3IN88UU4>	NGHhUYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxPFA6Pid-MkOwNVgxQTZ:L3G+
HepG2 cells	NGC5S2FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NYfaT3poPDhiaB?=	MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgcYV1cG:mLDDJR\|UxKD1iNj63N{DPxE1w	M1\M[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEG4NFk3Lz5{M{CxPFA6PjxxYU6=
BGC823 cells	MnLhRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		MWK0PEBp	NHXFUWFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLHR\|gzOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKG2ndHjv[EwhUUN3MDC9JFYvQDNizszNMi=>	NUjG[ZF{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVgxQTZpPkKzNFE5ODl4PD;hQi=>
HeLa cells	Mo\4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		MXq0PEBp	NHvLfFRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBu\XSqb3SsJGlEPTBiPTC5MlEzKM7:TT6=	NEfxRmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxPFA6Pid-MkOwNVgxQTZ:L3G+
HCT116 cells	M3rNZWZ2dmO2aX;uJIF{e2G7			MmLUTY5pcWKrdHnvckBw\iCWTlnLMY1m\GmjdHXkJHRETjRxYnX0ZU1k[XOnaX6geJJidnOlcnnweIlwdiCrbjDoeY1idiCKQ2SxNVYh[2WubIOgZpkh[mW2YT3sZYN1[W2jc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3MDC9JFAvODN7IN88UU4>	NEPmTJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{KzNlA3OCd-MkOyN\|IxPjB:L3G+
HepG2 cells	NHfYXmJHfW6ldHnvckBie3OjeR?=		NW\oN2l6PDhiaB?=	M1vSdWlvcGmkaYTpc44hd2ZidHXsc41memG\|ZTDpckBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgWHJCWC2SQ2KtSWxKW0FuIFnDOVAhRSB6LkOg{txONg>?	NYPUUZhvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyO\|k5PjRpPkKzNlc6QDZ2PD;hQi=>
SW1116 cells	NWLFXVk5TnWwY4Tpc44h[XO\|YYm=		Mm\WNlQhcA>?	NULBd5VGUW6qaXLpeIlwdiCxZjD0[YxwdWW{YYPlJIlvKGi3bXHuJHNYOTFzNjDj[YxteyCjZoTldkAzPCCqcoOgZpkhXFKDUD3QR3IuTUyLU1GgZZN{[XluIFnDOVAhRSB2LkG4JO69VS5?	M3TqclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mki2O\|YyLz5{NEK4Olc3OTxxYU6=
KE-97 cells	M1vsZmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NVHsUFNWPzJiaB?=	MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLSU06PyClZXzsd{Bi\nSncjC3NkBpenNiYomgR4VtdFSrdILlMWdtdyCudX3pcoV{[2WwdDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFAvOTNizszNMi=>	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN{OEK4N{c,OjR\|MkiyPFM9N2F-
Jurkat cells	MkTXR5l1d3SxeHnjbZR6KGG\|c3H5		MmP4O\|IhcA>?	MlvWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTpVzc2G2IHPlcIx{KGGodHXyJFczKGi{czDifUBE\WyuVHn0doUuT2yxIHz1cYlv\XOlZX70JINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOC5zNDFOwG0v	Mnq5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|MkiyPFMoRjJ2M{K4Nlg{RC:jPh?=
HuH7 cells	NH:0d\|lEgXSxdH;4bYNqfHliYYPzZZk>		M2XmSFczKGh?	M4\tUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh2UDdiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTy[U1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjJ\|IN88UU4>	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN{OEK4N{c,OjR\|MkiyPFM9N2F-
BGC823 cells	NWq4fmZtS3m2b4TvfIlkcXS7IHHzd4F6		NVzQWnpkPzJiaB?=	NGr3dYFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDT0N6MkOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRz\S2JbH:gcJVucW6nc3PlcpQh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSByLkO4JO69VS5?	NXzIfJJPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNlgzQDNpPkK0N\|I5Ojh\|PD;hQi=>
MCF7 cells	NXO5PJJ5S3m2b4TvfIlkcXS7IHHzd4F6		MWS3NkBp	M{T0[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTy[U1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjV{IN88UU4>	NVHmTVRjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNlgzQDNpPkK0N\|I5Ojh\|PD;hQi=>
NIH/3T3 cells	NUnkT4E4S3m2b4TvfIlkcXS7IHHzd4F6		NVL0eFZzQTZiaB?=	MnHqR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgUmlJNzOWMzDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOC5{IN88UU4>	NH\XSIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO2NVUzOSd-MkSzOlE2OjF:L3G+
A2780 cells	MkPYR5l1d3SxeHnjbZR6KGG\|c3H5		Mn2xPVYhcA>?	M2DtPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPzhyIHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAxNjJizszNMi=>	Mn3vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|NkG1NlEoRjJ2M{[xOVIyRC:jPh?=
HT-29 cells	MoTXR5l1d3SxeHnjbZR6KGG\|c3H5		M1PJT\|k3KGh?	MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG\|c3H5MEBKSzVyIE2gNE4zKM7:TT6=	NFXqflE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO2NVUzOSd-MkSzOlE2OjF:L3G+
8505C cells	MnrNR5l1d3SxeHnjbZR6KGG\|c3H5		NVXDXVNkQTZiaB?=	NWjBOFF3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hQDVyNVOgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDBwMjFOwG0v	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4MUWyNUc,OjR\|NkG1NlE9N2F-
518A2 cells	NV\I[IUzS3m2b4TvfIlkcXS7IHHzd4F6		M{jXW\|k3KGh?	NXnDO2JOS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hPTF6QUKgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDBwMjFOwG0v	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4MUWyNUc,OjR\|NkG1NlE9N2F-
MCF7 cells	NVG5dXNUS3m2b4TvfIlkcXS7IHHzd4F6		NGPuTZQ6PiCq	MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTBiPTCwMlQh\|ryPLh?=	MmHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|NkG1NlEoRjJ2M{[xOVIyRC:jPh?=
A549 cells	M2rKWWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NITW[GI6PiCq	NUja[XpUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOC54IN88UU4>	MlXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|NkG1NlEoRjJ2M{[xOVIyRC:jPh?=
V79 MZ cells	M2rnT2Z2dmO2aX;uJIF{e2G7			MYrJcohq[mm2aX;uJI9nKGi3bXHuJIFt\G:\|dHXyc45mKHO7boToZZNmKGW6cILld5Nm\CCrbjDWO\|khVVpiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBidGSxc4Tldo9v\SC\|eX70bIV{cXNuIFnDOVAhRSByLkCxNUDPxE1w	NXj1NZdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0NlI2OTlpPkK0OFIzPTF7PD;hQi=>
HEK293 cells	MkL0R5l1d3SxeHnjbZR6KGG\|c3H5		MnXtO\|IhcA>?	MYjDfZRwfG:6aXPpeJkh[WejaX7zeEBJTUt{OUOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmekeubzDhd5NigSxiSVO1NEA:KDBwMEW2JO69VS5?	NUPwZY8zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OlMzPjJpPkK0O\|Y{OjZ{PD;hQi=>
HeLa cells	NVfQSpFpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		M4H6OVI1KHSxIES4JIg>	NGPUPXdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiMkSgeI8hPDhiaILzJIJ6KEOFSz24JIF{e2G7LDDJR\|UxKD1iMj63NkDPxE1w	M{jBeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{myPFEyLz5{NEe5NlgyOTxxYU6=
A549 cells	M3XQNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		NYLDNoJpOjRidH:gOFghcA>?	M1LuTGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB{NDD0c{A1QCCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB\|LkC1JO69VS5?	MknnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5OUK4NVEoRjJ2N{myPFEyRC:jPh?=
HepG2 cells	MX7DfZRwfG:6aXPpeJkh[XO\|YYm=			MnrIR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMtKEWFNUCgQUAzKM7:TT6=	M1nYe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{G2N\|E4Lz5{NUOxOlMyPzxxYU6=
Raji cells	NEjGN2tEgXSxdH;4bYNqfHliYYPzZZk>			NEPFUmVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBT[WqrIHPlcIx{NCCHQ{WwJF0hOiEQvF2u	NV2y[GJORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNVY{OTdpPkK1N\|E3OzF5PD;hQi=>
BJ cells	M{DrW2N6fG:2b4jpZ4l1gSCjc4PhfS=>			MlLUR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRmoh[2WubIOsJGVEPTBiPTCyJO69VS5?	NX7aZ25JRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNVY{OTdpPkK1N\|E3OzF5PD;hQi=>
HEK293 cells	MYDDfZRwfG:6aXPpeJkh[XO\|YYm=			M2S4TmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEiHS{K5N{Bk\WyuczygSWM2OCB;IEKg{txONg>?	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTNzNkOxO{c,OjV\|MU[zNVc9N2F-
A549 cells	MknlR5l1d3SxeHnjbZR6KGG\|c3H5		MmjsOFghcA>?	M2T0dmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODJizszNMi=>	M{\uXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK1PVM1Lz5{NUiyOVk{PDxxYU6=
HeLa cells	NX\wWopCS3m2b4TvfIlkcXS7IHHzd4F6		Mnm1OFghcA>?	NXLFU\|B1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMkWg{txONg>?	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh{NUmzOEc,OjV6MkW5N\|Q9N2F-
PC3 cells	M4\XOWN6fG:2b4jpZ4l1gSCjc4PhfS=>		M3HFNFQ5KGh?	M13C[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNE4xOzFizszNMi=>	M2eySFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK1PVM1Lz5{NUiyOVk{PDxxYU6=
MGC-803 cells	M2mzW2Z2dmO2aX;uJIF{e2G7		MX2yOEBp	MX\Jcohq[mm2aX;uJI9nKHSnbH;t[ZJie2ViaX6gbJVu[W5iTVfDMVgxOyClZXzsd{Bi\nSncjCyOEBpenNiYomgWHJCWC2SQ2KtSWxKW0FiYYPzZZktKEmFNUCgQUA5Njl5IN88UU4>	NFnDZlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkmwNFY2Pid-Mk[5NFA3PTZ:L3G+
Sf9 insect cells	NXTrUnZlTnWwY4Tpc44h[XO\|YYm=		M4LVRVExKG2rboO=	MXPJcohq[mm2aX;uJI9nKE5vdHXycYlv[WxiR2PUJJRi\2enZDDy[YNwdWKrbnHueEBnfWyuLXzlcod1cCCqdX3hckBEUEtzIHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCVZkmgbY5{\WO2IHPlcIx{KGGodHXyJFExKG2rboOgZpkhdHWvaX7ld4NmdnRiQVTQMWdtdyCjc4PhfUwhUUN3MDC9JFAvODBzMjFOwG0v	M4npUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEi5NlEyLz5{N{C4PVIyOTxxYU6=
Sf21 cells	MYDGeY5kfGmxbjDhd5NigQ>?		Ml3BOlAhdWmwcx?=	M{i4eGlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSlHLNkBmgHC{ZYPz[YQhcW5iU3[yNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iVXzp[4h1NUODR1HHRWlGXESNRWnZWHZMTCCyaH;zdIhwenmuYYTpc44heHKnLXnuZ5Vj[XSnZDDi[YZwemVic4Xid5Rz[XSnIHHk[Il1cW:wIHHu[EBu\WG\|dYLl[EBi\nSncjC2NEBucW6\|IHL5JGxCVkOHIHTleIVkfGmxbjDt[ZRpd2RuIFnDOVAhRSByLkCwNkDPxE1w	M3HVTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUO3N\|U6Lz5{N{GzO\|M2QTxxYU6=
Neuro2a cells	MVfDfZRwfG:6aXPpeJkh[XO\|YYm=		Mmj3O\|IhcA>?	NXvMXpBTS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhVmW3cn:yZUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD6wNVE{KM7:TT6=	M3HlU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUWyOFI4Lz5{OEG1NlQzPzxxYU6=
MDA-MB-231 cells	M4PO[GZ2dmO2aX;uJIF{e2G7		NYHN[oliOTZiaB?=	M1PieWlvcGmkaYTpc44hd2ZicnX0bY5w[myjc4TvcYEheHKxdHXpckBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiBzNjDodpMh[nliSH;lZ4h{fCB\|M{O0NkB{fGGrbnnu[{Bj[XOnZDDmcJVwemW\|Y3XuZ4Uh[XO\|YYmsJGlEPTBiPTCwMlA3PiEQvF2u	M2fqe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEOxN\|QzLz5{OESzNVM1OjxxYU6=
Sf9 insect cells	MljDSpVv[3Srb36gZZN{[Xl?		NF65UlgzOCCvaX7z	MlXTTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCQLYTldo1qdmGubImgS3NVNXSjZ3fl[EBGT0[UIFy4OVhTN1R5OUDNM2M4QTeVIITybZBt\SCvdYThcpQh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlvKFOoOTDpcpNm[3RiY3XscJMheHKnaX7jeYJifGWmIH\vdkAzOCCvaX7zJIZwdGyxd3XkJIJ6KGGmZHn0bY9vKG:oIGuzN3BeNUGWUDDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCoaXz0[ZIu[mmwZHnu[{Bu\XSqb3SsJGlEPTBiPTCwMlAxODJ7IN88UU4>	NXfqflJHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0PFIyPTFpPkK4OFgzOTVzPD;hQi=>
HEK293 cells	MX7DfZRwfG:6aXPpeJkh[XO\|YYm=		NFrPR5c4OiCq	MlrvR5l1d3SxeHnjbZR6KGGpYXnud5QhUEWNMkmzJINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKgS4xwKGy3bXnu[ZNk\W62IHHzd4F6NCCFQ{WwJF0hOC5yMEO1OEDPxE1w	M1q4WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkK0O\|AyLz5{OE[yOFcxOTxxYU6=
BT549 cells	M4m0[2N6fG:2b4jpZ4l1gSCjc4PhfS=>		NW\yWpJwOjRiaB?=	NEHQdpVEgXSxdH;4bYMh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWFU1QSClZXzsd{BqdmO3YnH0[YQh\m:{IEK0JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlA5KM7:TT6=	MoPMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MEW0N\|IoRjJ6N{C1OFMzRC:jPh?=
MDA-MB-468 cells	M4XMSWN6fG:2b4jpZ4l1gSCjc4PhfS=>		MVWyOEBp	MXnDfZRwfG:6aXOgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPRFGtUWIuPDZ6IHPlcIx{KGmwY4XiZZRm\CCob4KgNlQhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOTVizszNMi=>	MnPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MEW0N\|IoRjJ6N{C1OFMzRC:jPh?=
MDA-MB-231 cells	M1jpTGN6fG:2b4jpZ4l1gSCjc4PhfS=>		MkHrNlQhcA>?	NUfSN4MzS3m2b4TvfIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkK0JO69VS5?	M{HqeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{C1OFMzLz5{OEewOVQ{OjxxYU6=
Vero cells	MYfDfZRwfG:6aXPpeJkh[XO\|YYm=		M4XPNVIh\GG7cx?=	NX;KN41XS3m2b4TvfIlkcXS7IHHnZYlve3RiQX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOiCmYYnzJIJ6KGOnbHyteIl1\XJvZ3zvJIx2dWmwZYPj[Y51KGG\|c3H5MEBVSzVyIE2gNE4xODJ2IN88UU4>	NHy3V3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEe2N\|Y1PSd-Mki3OlM3PDV:L3G+
L929 cells	MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		M4mwWFUh\GG7cx?=	MkHVRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCOOUK5JINmdGy\|IHHmeIVzKDViZHH5d{BjgSCZU2StNUBie3OjeTygTWM2OCB;IECuNkDPxE1w	MkPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NU[5NVUoRjJ6OUW2PVE2RC:jPh?=
KB-3-1 cells	NG\PdJlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NGrLfHY2KGSjeYO=	NGHoR4JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvCMVMuOSClZXzsd{Bi\nSncjC1JIRigXNiYomgW3NVNTFiYYPzZZktKEmFNUCgQUAxNjJizszNMi=>	NXrvNFlIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OTVpPkK4PVU3QTF3PD;hQi=>
MCF7 cells	MoPMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		MmXPOUBl[Xm\|	MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPSCmYYnzJIJ6KFeVVD2xJIF{e2G7LDDJR\|UxKD1iMT64JO69VS5?	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmxOUc,Ojh7NU[5NVU9N2F-
FS4-LTM cells	NVG1NnZqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		NV3uWmt7OjRiaB?=	NXnCfXZ5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDGV\|QuVFSPIHPlcIx{KGGodHXyJFI1KGi{czDifUBYW1RvMTDhd5NigSxiSVO1NEA:KDJwODFOwG0v	MoXPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NU[5NVUoRjJ6OUW2PVE2RC:jPh?=
Vero cells	M3ThfGN6fG:2b4jpZ4l1gSCjc4PhfS=>		M3jw[lIh\GG7cx?=	NYnYT\|VpS3m2b4TvfIlkcXS7IHHnZYlve3RiQX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bi\nSncjCyJIRigXNiYomgR4VtdFSrdHXyMWdtdyCudX3pcoV{[2WwdDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFAvODB{NDFOwG0v	Mn;OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7OUOxNFYoRjJ6OUmzNVA3RC:jPh?=
HepG2 cells	NUfZdlZ7S3m2b4TvfIlkcXS7IHHzd4F6	MXmxNFAhfU1?	MX:zJIRigXN?	M1LhbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG2IEGwNEB2VSCjZoTldkA{KGSjeYOgZpkhS2WubGTpeIVzNUeubzDseY1qdmW\|Y3XueEBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDBwMEG4JO69VS5?	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl7M{GwOkc,Ojh7OUOxNFY9N2F-
NIH/3T3 cells	M{T3[2N6fG:2b4jpZ4l1gSCjc4PhfS=>		NWX5dXpZQTZiaB?=	NH2wO3dEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBPUUhxM2SzJINmdGy\|IHHmeIVzKDl4IHjyd{BjgSCVUlKgZZN{[XluIFXDOVAhRSByLkCwPEDPxE1w	NFTOOZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUG5O\|c{OCd-MkmxPVc4OzB:L3G+
518A2 cells	NHjIUFJEgXSxdH;4bYNqfHliYYPzZZk>		MlO2PVYhcA>?	NWezSZJmS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hPTF6QUKgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiRVO1NEA:KDBwMEOg{txONg>?	M3\nfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUm3O\|MxLz5{OUG5O\|c{ODxxYU6=
A549 cells	MXTDfZRwfG:6aXPpeJkh[XO\|YYm=		MUi5OkBp	M{LNVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgPVYhcHK\|IHL5JHNTSiCjc4PhfUwhTUN3MDC9JFAvODRizszNMi=>	MmrsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzOUe3N\|AoRjJ7MUm3O\|MxRC:jPh?=
MCF7 cells	MX\DfZRwfG:6aXPpeJkh[XO\|YYm=		Ml;0PVYhcA>?	Ml7aR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG\|c3H5MEBGSzVyIE2gNE4yKM7:TT6=	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF7N{ezNEc,OjlzOUe3N\|A9N2F-
A2780 cells	M2faTmN6fG:2b4jpZ4l1gSCjc4PhfS=>		Mm\1PVYhcA>?	NGGzeZlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCOjd6MDDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCHQ{WwJF0hOC5zMjFOwG0v	M{DyfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUm3O\|MxLz5{OUG5O\|c{ODxxYU6=
HT-29 cells	NEi3OnZEgXSxdH;4bYNqfHliYYPzZZk>		MV[5OkBp	Mm\nR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgPVYhcHK\|IHL5JHNTSiCjc4PhfUwhTUN3MDC9JFAvOTVizszNMi=>	M2D0UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUm3O\|MxLz5{OUG5O\|c{ODxxYU6=
PC3 cells	M4TLZWN6fG:2b4jpZ4l1gSCjc4PhfS=>			NVzI[3lZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN\|IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEmFNUCgQUAxNjBzNzFOwG0v	Mlr2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl\|OEmxNlIoRjJ7M{i5NVIzRC:jPh?=
HCT116 cells	MVrDfZRwfG:6aXPpeJkh[XO\|YYm=			MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3MDC9JFAvODV3IN88UU4>	M3jrTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{i5NVIzLz5{OUO4PVEzOjxxYU6=
insect cells	NITVUVlHfW6ldHnvckBie3OjeR?=		M1rzTVMxKG2rboO=	MoL1TY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCSRFfGVoJmfGFiZYjwdoV{e2WmIHnuJIlve2WldDDj[YxteyC3c3nu[{BWdGmpaIStVI9tgSCJQWTbSWF[MDF8MUqxLX1vKGG\|IIP1ZpN1emG2ZTDh[pRmeiB\|MDDtbY5{KGK7IFzBUmNGKG2ndHjv[EwhUUN3MDC9JFAvODByN{[g{txONg>?	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2OUizOkc,Ojl3NEm4N\|Y9N2F-
Sf9 insect cells	MU\GeY5kfGmxbjDhd5NigQ>?		NES0dHU3OCCvaX7z	NHuyN25KdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIFvEVkBmgHC{ZYPz[YQhcW5iU3[5JIlve2WldDDj[YxteyC3c3nu[{BWdGmpaIStR2FISUeDSVXUSGtGYVmWVlvEJIF{KHO3YoP0doF1\SCjZoTldkA3OCCvaX7zJIJ6KEyDTlPFJI1mfGixZDygTWM2OCB;IECuNFAzOSEQvF2u	NUTuZWNrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
insect cells	NIi4eVFHfW6ldHnvckBie3OjeR?=		NVzRSZpQOTBibXnudy=>	NFHiVZZKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIGPyZ{BmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJJV{cW6pIGXsbYdpfC2Sb3z5JGdCXFuHQWmoNVoyQjFrXX6gZZMhe3Wkc4TyZZRmKGGodHXyJFExKG2rboOgZpkhVEGQQ1WgcYV1cG:mLDDJR\|UxKD1iMD6wNFUh\|ryPLh?=	NWjXNIc{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
insect cells	M2Pm[WZ2dmO2aX;uJIF{e2G7		NEfheJAyPSCvaX7z	NYXkW2ZmUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDDSGsyN0O7Y3zpckBDKGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMhfXOrbnegWYxq\2i2LVPGSmtPUV[WUGLUVHBRW1GJSz3hcYll\SCjczDzeYJ{fHKjdHWgZYZ1\XJiMUWgcYlveyCkeTDMRW5ETSCvZYToc4QtKEmFNUCgQUAxNjB{NTFOwG0v	MlPQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NEm4N\|YoRjJ7NUS5PFM3RC:jPh?=
insect cells	MV\GeY5kfGmxbjDhd5NigQ>?		MX[xOUBucW6\|	NWDNflVZUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDDSGsyN0O7Y3zpckBDKGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMhfXOrbnegWYxq\2i2LVPGSmtPUV[WUGLUVHBRW1GJSz3hcYll\SCjczDzeYJ{fHKjdHWgZYZ1\XJiMUWgcYlveyCkeTDMRW5ETSCvZYToc4QtKEmFNUCgQUAxNjB{NTFOwG0v	NX;CWHpDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
Sf9 insect cells	NWDQUHZsTnWwY4Tpc44h[XO\|YYm=		MVGxOUBucW6\|	MXfJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKE[udEGg[ZhxemW\|c3XkJIlvKFOoOTDpcpNm[3RiY3XscJMhfXOrbnegWYxq\2i2LWTLJJBmeHSrZHWgZZMhe3Wkc4TyZZRmKGGodHXyJFE2KG2rboOgZpkhVEGQQ1WgcYV1cG:mLDDJR\|UxKD1iMD6wN\|Uh\|ryPLh?=	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2OUizOkc,Ojl3NEm4N\|Y9N2F-
Sf21 insect cells	MV;GeY5kfGmxbjDhd5NigQ>?		Mk\0NVUhdWmwcx?=	NEDwd2xKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIFH1do9z[S2DIHX4dJJme3OnZDDpckBU\jJzIHnud4VkfCClZXzsd{B2e2mwZzDVcIlocHRvUmLSV2xNTSCjczDzeYJ{fHKjdHWgZYZ1\XJiMUWgcYlveyCkeTDMRW5ETSCvZYToc4QtKEmFNUCgQUAxNjB\|OTFOwG0v	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2OUizOkc,Ojl3NEm4N\|Y9N2F-
insect cells	NXLOWGdXTnWwY4Tpc44h[XO\|YYm=		NXTjRYlSPjBibXnudy=>	NWXSO4RPUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDBT3QyKGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMhfXOrbnegR3JGSnSrZHWgZZMhe3Wkc4TyZZRmKGGodHXyJFYxKG2rboOgZpkhVEGQQ1WgcYV1cG:mLDDJR\|UxKD1iMD6wOVYh\|ryPLh?=	Ml7wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NEm4N\|YoRjJ7NUS5PFM3RC:jPh?=
Sf9 insect cells	MlztSpVv[3Srb36gZZN{[Xl?		NEexNHg3OCCvaX7z	MlnLTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCIQVug[ZhxemW\|c3XkJIlvKFOoOTDpcpNm[3RiY3XscJMhfXOrbnegWYxq\2i2LWTLJJBmeHSrZHWgZZMhe3Wkc4TyZZRmKGGodHXyJFYxKG2rboOgZpkhVEGQQ1WgcYV1cG:mLDDJR\|UxKD1iMD6wOlIh\|ryPLh?=	NXnLZolORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
insect cells	M2nxbmZ2dmO2aX;uJIF{e2G7		Ml;IOlAhdWmwcx?=	NGXaWphKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIFHCUEBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJJV{cW6pIGXsbYdpfC2WSzDw[ZB1cWSnIHHzJJN2[nO2cnH0[UBi\nSncjC2NEBucW6\|IHL5JGxCVkOHIH3leIhw\CxiSVO1NEA:KDBwMkmg{txONg>?	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2OUizOkc,Ojl3NEm4N\|Y9N2F-
insect cells	NGPrS3pHfW6ldHnvckBie3OjeR?=		NV:zbGlUPjBibXnudy=>	NWDSZYVTUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDjMW1GXCCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KHW\|aX7nJHVtcWeqdD3DRWdCT0GLRWTET2V[YVSYS1SgZZMhe3Wkc4TyZZRmKGGodHXyJFYxKG2rboOgZpkhVEGQQ1WgcYV1cG:mLDDJR\|UxKD1iMD6zNUDPxE1w	NUTkb2Y1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
PC3 cells	M3vITWN6fG:2b4jpZ4l1gSCjc4PhfS=>		M{DmW\|czKGh?	MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR\|Mh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IECuNFM6KM7:TT6=	M1zMdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUW4NVE6Lz5{OUW1PFEyQTxxYU6=
Sf9 cells	M1GzcWZ2dmO2aX;uJIF{e2G7		MYW0OUBucW6\|	NYLEWVg2UW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDDMZRmem2rbnHsJGhqey22YXfn[YQwVi22ZYLtbY5idCCJU2SteIFo\2WmIFXHSnIhMDZ4ODD0c{AyOjFyIILld4llfWW\|KTDlfJBz\XO\|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiU3[5JINmdGy\|IIXzbY5oKFCxbImtLGdtfSxiVInyLUBieyC\|dXLzeJJifGVibXXhd5Vz\WRiYX\0[ZIhPDVibXnueZRmeyCkeTDLbY5ie2VvR3zvJIx2dWmwZYPj[Y51KGG\|c3H5MEBKSzVyIE2gNE4xPDdizszNMi=>	MlPuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7MEK3NVkoRjJ7OUCyO\|E6RC:jPh?=
Sf9 cells	MYDGeY5kfGmxbjDhd5NigQ>?		NX\ETlJGPDVibXnudy=>	MoHYTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCQLYTldo1qdmGuIFfTWE11[WepZXSgTGVTOiBqNke5JJRwKDF{NUWgdoV{cWS3ZYOpJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDT[lkh[2WubIOgeZNqdmdiUH;sfU0pT2y3LDDUfZIqKGG\|IIP1ZpN1emG2ZTDt[YF{fXKnZDDh[pRmeiB2NTDtbY52fGW\|IHL5JGtqdmG\|ZT3HcI8hdHWvaX7ld4NmdnRiYYPzZZktKEmFNUCgQUAxNjB4MEig{txONg>?	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTlyMkexPUc,Ojl7MEK3NVk9N2F-
HT-29 cells	M4TIZ2Z2dmO2aX;uJIF{e2G7		NH;LNmU{KGh?	NVvWfHN[UW6qaXLpeIlwdiCxZjDtbZRw[2ixbnTybYFtKG2nbXLyZY5mKHCxdHXueIlidCCrbjDoeY1idiCKVD2yPUBk\WyuczDh[pRmeiB\|IHjyd{BjgSCMQz2xJJN1[WmwaX7nJIJie2WmIH\seY9z\XOlZX7j[UBie3OjeTygTWM2OCB;IECuNFIh\|ryPLh?=	NGC3UVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC1O\|E2PSd-M{CwOVcyPTV:L3G+
Sf9 cells	MmK5SpVv[3Srb36gZZN{[Xl?			NHKzXlRKdmirYnn0bY9vKG:oIF6teIVzdWmwYXygSmxCTy22YXfn[YQhcHWvYX6g[pVtdC2uZX7neIghS0SNMUKgLFEhfG9iMUS5NEBz\XOrZIXld{kwVi22ZYLtbY5idCCKaYOteIFo\2WmIFP5Z2shMDFidH:gOVgxKHKnc3nkeYV{MSCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDBWHAu\GWyZX7k[Y51KFWOaXfoeE01TS2EUEGgLHRpejN5L2TodlQ3MSC\|dXLzeJJifGVicHXweIll\SCyaH;zdIhwenmuYYTpc44heHJuIFnDOVAhRSByLkC1N{DPxE1w	NHPzTGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC2O\|M2QCd-M{CwOlc{PTh:L3G+
Sf9 cells	NVXyfWtvTnWwY4Tpc44h[XO\|YYm=			NELmbIpKdmirYnn0bY9vKG:oIF6teIVzdWmwYXygSmxCTy22YXfn[YQhcHWvYX6g[pVtdC2uZX7neIghS0SNMUKgLFEhfG9iMUS5NEBz\XOrZIXld{kwVi22ZYLtbY5idCCKaYOteIFo\2WmIFP5Z2shMDFidH:gOVgxKHKnc3nkeYV{MSCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDBWHAu\GWyZX7k[Y51KFWOaXfoeE01TS2EUEGgLHRpejN5L2TodlQ3MSC\|dXLzeJJifGVicHXweIll\SCyaH;zdIhwenmuYYTpc44heHJuIFnDOVAhRSByLkC1N{DPxE1w	MoLjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNkezOVgoRjNyME[3N\|U5RC:jPh?=
Sf9 cells	NGm1SGZHfW6ldHnvckBie3OjeR?=			M3uw[mlvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDGUGFINXSjZ3fl[EBpfW2jbjDmeYxtNWynbnf0bEBETEtzMzCoNUB1dyBzNUGyJJJme2mmdXXzLU9PNXSncn3pcoFtKEircz30ZYdo\WRiQ4njT{ApOSC2bzC1PFAhemW\|aXT1[ZMqKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIFHUVE1l\XCnbnTlcpQhXUyrZ3j0MVRGNUKSMTCoWIhzOzdxVHjyOFYqKHO3YoP0doF1\SCyZYD0bYRmKHCqb4PwbI9zgWyjdHnvckBxeixiSVO1NEA:KDBwMEW3JO69VS5?	NGfy[Zk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC2O\|M2QCd-M{CwOlc{PTh:L3G+
Sf9 cells	M1X6eWZ2dmO2aX;uJIF{e2G7			NX;TS\|UxUW6qaXLpeIlwdiCxZjDOMZRmem2rbnHsJGZNSUdvdHHn[4VlKGi3bXHuJIZ2dGxvbHXu[5RpKEOGS{GzJEgyKHSxIEG1NVIhemW\|aXT1[ZMqN05vdHXycYlv[WxiSHnzMZRi\2enZDDDfYNMKChzIITvJFU5OCC{ZYPp[JVmeyliZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gRXRRNWSncHXu[IVvfCCXTHnnbJQuPEVvQmCxJEhVcHJ\|Nz;UbJI1Pilic4Xid5Rz[XSnIIDldJRq\GVicHjvd5Bpd3K7bHH0bY9vKHC{LDDJR\|UxKD1iMD6wOVch\|ryPLh?=	Mm\BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNkezOVgoRjNyME[3N\|U5RC:jPh?=
HCT116 cells	NUPXVWQ4S3m2b4TvfIlkcXS7IHHzd4F6		M3P0e\|Q5KGh?	NVv1PHFVS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlA{KM7:TT6=	NUTCVWo{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxNFYzQTFpPkOwNVA3OjlzPD;hQi=>
Huh7.5 cells	MkPvR5l1d3SxeHnjbZR6KGG\|c3H5		MkfTOFghcA>?	M3Xt[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh2cDdwNTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG\|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD62JO69VS5?	NV;LSXEyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxNFYzQTFpPkOwNVA3OjlzPD;hQi=>
K562 cells	M1nNXWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NUDXZoRiPDhiaB?=	M{LkOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwNzFOwG0v	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODFyNkK5NUc,OzBzME[yPVE9N2F-
LO2 cells	NVP0RWRtS3m2b4TvfIlkcXS7IHHzd4F6		NVPOd4lKPDhiaB?=	NEnrUHdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNVzJiY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDlwNTFOwG0v	M4ruTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUC2NlkyLz5\|MEGwOlI6OTxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	FAK / RIP; PubMed: 15121855 Mol Cell Biol Western blot (WB) analysis of BT-20 and BT-474 lysates treated with staurosporine (200 nM). Control cells were treated with dimethyl sulfoxide for 18 h. p-Akt / Akt / PARP /Cleaved PARP; PubMed: 24174874 Int J Nanomedicine Western blot analysis for Akt, P-Akt, and cleaved poly(ADP-ribose) polymerase. U87 cells were incubated with 200 nM, 10 nM, and 0.1 nM of staurosporine encapsulated in liposomes and staurosporine for 32 hours. Ambra1; PubMed: 24587252 PLoS One SW620 cells treated with various doses of staurosporine for 6 h. Ambra1 levels were measured by Western blot.	15121855 24174874 24587252
Growth inhibition assay	Cell viability; PubMed: 25215174 Oxid Med Cell Longev Staurosporine reduces cerebellar astrocytes viability. (a) Cerebellar astrocytes were treated with staurosporine 0.1 μM, 0.25 μM, and 0.5 μM for 24 h and the cell viability was measured by MTT transformation. (b) Cerebellar astrocytes were treated with staurosporine 0.5 μM for 6, 12, and 24 h and the cell viability was measured by MTT transformation. Data are presented as mean ± SEM of four independent experiments. ∗ is significantly different from control (P < 0.05).	25215174
Immunofluorescence	Phalloidin / Type II collagen; PubMed: 22684244 Exp Mol Med Cell were cultured in the absence (a-f) or presence of staurosporine (STSN, 5 × 10-9M) or cytochalasin D (CD, 1 µg/ml) for 1 (upper panel) or 2 (lower panel) days at low density and stained for F-actin (Phalloidin) and type II collagen (Type II). STSN: Staurosporine. Tubulin / Actin; PubMed: 25215174 Oxid Med Cell Longev Morphological changes of astrocytes induced by St are evidenced by the rearrangement of cytoskeletal proteins. Astrocytes were treated with St (0.5 μM) for 12 hours and then were labelled with rhodamine-phalloidin or immunostained for tubulin. Representative images of phase contrast, rhodamine-phalloidin, and tubulin are shown in control and St treated astrocytes. Scale bar represents 50 μm. FAK 4.47; PubMed: 15121855 Mol Cell Biol BT-20 or BT-474 cell culture were plated on six-well plates and were treated with staurosporine (200 nM) after 24 h. After 6 h of treatment, cells were immunostained with anti-FAK 4.47 antibody (white arrowheads mark some focal adhesions). cleaved-caspase 3; PubMed: 19840952 Cardiovasc Res Representative images (×1000 magnification) showing vehicle treated (C) and staurosporine treated (D) cells stained with anti-cleaved caspase 3 antibody and DAPI. Annexin; PubMed: 15140398 Neoplasia Induction of apoptosis with staurosporine resulting in activation of the ICE-NIRF probe. Gli36 cells were treated with 50 µM staurosporine for 24 hours (A-C) or with the same percentage of DMSO (0.01%) to which experimental wells were exposed (D-488nm laser, E-633nm laser and F-bright field). To examine the role of caspase-1 in staurosporine-induced apoptosis and probe activation, cells were coincubated in caspase-1 inhibitor (10 µM) and staurosporine (G-I). Staurosporine induces apoptosis, indicated by the positive annexin staining viewed with the 488-nm laser (A), which colocalized with activated probe viewed with the 633-nm laser (B). Coincubation of the caspase-1 inhibitor with staurosporine did not completely block apoptosis, indicated by the relatively higher number of apoptotic cells stained with annexin (G), as those that activated the probe (H). Magnification, x 40; scale bar, 50 µM. Pyk2; PubMed: 19880522 J Biol Chem Pyk2 translocates to the nucleus upon staurosporine addition to ID8 cells. Confocal immunofluorescent analysis of endogenous Pyk2 upon DMSO (control) or 1 μm staurosporine addition for 2 h. The scale bar is 10 μm.	22684244 25215174 15121855 19840952 15140398 19880522

In vivo

In the gerbil and rat ischemia models, Staurosporine pretreatment (0.1-10 ng) before ischemia prevents neuronal damage in a dose-dependent manner, suggesting the involvement of PKC in CAl pyramidal cell death after ischemia. ^[8]

Protocol

Kinase Assay: ^[1]	- Collapse Enzyme assay and binding assay: Protein kinase C is assayed in a reaction mixture (0.25 mL) containing 5 μmol of Tris/HCl, pH 7.5, 2.5 μmol of magnesium acetate, 50 μg of histone II S, 20 μg of phosphatidylserine, 0.88 μg of diolein, 125 nmol of CaCl₂, 1.25 nmol of [γ-³²]ATP (5-10 × 10⁴ cpm/nmol) and 5 μg of partially purified enzyme. The binding of [³H]PDBu to protein kinase C is determined: Reaction mixture (200 μL contained 4 μmo1 of Tris/malate, pH 6.8, 20 μmol of KCl, 30 nmol of CaC1₂, 20 μg of phosphatidylserine, 5 μg of partially purified protein kinase C, 0.5% (final concentration) of DMSO,10 pmol of [³H]PDBu (l-3 × 10⁴ cpm/pmol) and 10 μL of various amounts of Staurosporine.
Cell Research: ^[3]	- Collapse Cell lines: PC12 Concentrations: Dissolved in DMSO, final concentration 1 μM Incubation Time: ~32 hours Method: Cells are exposed to Staurosporine for ~32 hours. Cells are fixed in 4% paraformaldehyde and stained with the DNA-binding dye Hoechst 33342. Cells are visualized under epifluorescence illumination, and the percentage of apoptotic cells (cells with condensed and fragmented DNA) is determined. (Only for Reference)
Animal Research: ^[8]	- Collapse Animal Models: Male Mongolian gerbils or male Wistar rats subjected to transient ischemia Dosages: ~10 ng Administration: Stereotaxically administered into the bilateral CAl subfield of the hippocampus (Only for Reference)

References

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Solubility (25°C)

In vitro	DMSO	4 mg/mL (8.57 mM)
	Water	Insoluble
	Ethanol	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Staurosporine (AM-2282) SDF

Molecular Weight	466.53
Formula	C₂₈H₂₆N₄O₃
CAS No.	62996-74-1
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	Antibiotic AM-2282, STS
Smiles	CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

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Staurosporine (AM-2282)