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Staurosporine

For research use only.

Catalog No.S1421 Synonyms: CGP 41251

88 publications

Staurosporine Chemical Structure

CAS No. 62996-74-1

Staurosporine (CGP 41251) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.

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Selleck's Staurosporine has been cited by 88 publications

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Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors

Biological Activity

Description Staurosporine (CGP 41251) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.
Targets
PKCα [1]
(Cell-free assay)
c-Fgr [2]
(Cell-free assay)
phosphorylase kinase [2]
(Cell-free assay)
PKCη [1]
(Cell-free assay)
PKCγ [1]
(Cell-free assay)
2 nM 2 nM 3 nM 4 nM 5 nM
In vitro

Staurosporine, a microbial alkaloid, significantly inhibits protein kinase C from rat brain with IC50 of 2.7 nM. Staurosporine displays strong inhibitory effect against HeLa S3 cells with IC50 of 4 nM. [1] Staurosporine also inhibits a variety of other protein kinases, including PKA, PKG, phosphorylase kinase, S6 kinase, Myosin light chain kinase (MLCK), CAM PKII, cdc2, v-Src, Lyn, c-Fgr, and Syk with IC50 of 15 nM, 18 nM, 3 nM, 5 nM, 21 nM, 20 nM, 9 nM, 6 nM, 20 nM, 2 nM, and 16 nM, respectively. [2] Staurosporine (1 μM) induces >90% apoptosis in PC12 cells. Consistently, Staurosporine treatment induces a rapid and prolonged elevation of intracellular free calcium levels [Ca2+]i, accumulation of mitochondrial reactive oxygen species (ROS), and subsequent mitochondrial dysfunction. [3] The apoptosis of MCF7 cells induced by Staurosporine can be enhanced by the expression of functional caspase-3 via caspase-8 activation and Bid cleavage. [4] Staurosporine treatment at 1 μM only partially inhibits IL-3-stimulated Bcl2 phosphorylation but completely blocks PKC-mediated Bcl2 phosphorylation. [5] Staurosporine induces apoptosis of human foreskin fibroblasts AG-1518, depending on the lysosomal cathepsins D mediated cytochrome c release and caspase activation. [6] In addition to activating the classical mitochondrial apoptosis pathway, Staurosporine triggers a novel intrinsic apoptosis pathway, relying on the activation of caspase-9 in the absence of Apaf-1. [7]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human colon carcinoma cell line HCT116 NGTGeYlHfW6ldHnvckBie3OjeR?= Ml3lR49v[2WwdILheIlwdiC{ZYH1bZJm\CCob4Kg[5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gZ49td25iY3HyZ4lvd22jIHPlcIwhdGmwZTDIR3QyOTZuIFnDOVA:PiCwTT6= NE[2bGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWzO|M1PSd-MUW1N|c{PDV:L3G+
human PBMC NEjONlhHfW6ldHnvckBie3OjeR?= M2LnclI1KGh? NFTscXdUfXCycnXzd4lwdiCxZjDJUFIheHKxZIXjeIlwdiCrbjDoeY1idiCSQl3DJIFnfGW{IEK0JIhzeyCkeTDFUGlUSSxiSVO1NF0yPiCwTT6= NH\qOng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW4OVA1Pid-MUi1PFUxPDZ:L3G+
endothelial cells NGHHO2VHfW6ldHnvckBie3OjeR?= MVTF[oZm[3SrdnWg[I9{\SCjZ3HpcpN1KHCuYYPtbY5w\2WwIHHjeIl3[XSxcjDhZ5Rqfmm2eTDzeIlufWyjdHXkJIJ6KHCqb4Lic4wh\XO2ZYKgbY4h\W6mb4To[Yxq[WxiY3XscJMtKEWGNUCgQUA4NjVizszNMi=> M4\NeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh5MEmwPVUoRjh5MEmwPVU9N2F-
Sf9 insect cells MkfnSpVv[3Srb36gZZN{[Xl? NVnoS2dTUW6qaXLpeIlwdiCxZjDwdo91\WmwIHvpcoF{\SCFKEG6NY1qgHS3cnWgc4YhWEuFIHHsdIhiKCZiYnX0ZUkh\XiycnXzd4VlKGmwIGPmPUBqdnOnY4SgZ4VtdHNuIFnDOVAhRSByLkCyJO69VS5? M4\mdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl6N{O2NFUoRjl6N{O2NFU9N2F-
LoVo cells M3;5WmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MUHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKGOxbH;uJINidmOncjDj[YxtKGyrbnWgLGxwXm9iY3XscJMqKHW|aX7nJG1VXCCjc4PhfUwhUUN3MDC9JFAvODBzIN88UU4> MnXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF3OUG1NFUoRjFzNUmxOVA2RC:jPh?=
umbilical vein endothelial cells NIGxTGpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MnXORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiC3bXLpcIlk[WxidnXpckBmdmSxdHjlcIlidCClZXzsd{ApUFWYRVPzLUB2e2mwZzDNWHQh[XO|YYmsJGlEPTBiPTCwMlAxPCEQvF2u NVv0N5A5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG1PVE2ODVpPkGxOVkyPTB3PD;hQi=>
ST-486 cells M1\aWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MmmwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDieZJscXRibIntdIhwdWFiY3XscEBtcW6nIDjTWE01QDZiY3XscJMqKHW|aX7nJG1VXCCjc4PhfUwhUUN3MDC9JFAvODB5IN88UU4> M3fFcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNUmxOVA2Lz5zMUW5NVUxPTxxYU6=
DLD-1 cells NFHlZYpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NYrHXnBMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubDDsbY5mKCiGTFStNUBk\WyuczmgeZNqdmdiTWTUJIF{e2G7LDDJR|UxKD1iMD6wNFkh|ryPLh?= MoG2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF3OUG1NFUoRjFzNUmxOVA2RC:jPh?=
HEK293 cells M1XjVWZ2dmO2aX;uJIF{e2G7 NGrvNldKdmirYnn0bY9vKG:oIGDLR{1j\XSjIFnJJI1m\GmjdHXkJGlNNThicnXs[YF{\SCocn;tJGhGUzJ7MzDj[YxteyCkeTDFUGlUSSxiSVO1NEA:KDBwMEe3JO69VS5? MoXLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ7NEGzN|EoRjF{OUSxN|MyRC:jPh?=
P19 cells M1fhVWZ2dmO2aX;uJIF{e2G7 MmS0TY5pcWKrdHnvckBw\iCSbHH0[YxmfC2mZYLpeoVlKGe{b4f0bEBn[WO2b4KgdoVk\XC2b4KgbY4hWDF7IHPlcIx{NCCLQ{WwJF0hOC5yMEKg{txONg>? M1vJTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{exOFE6Lz5zNUe3NVQyQTxxYU6=
P19 cells NGHvfINHfW6ldHnvckBie3OjeR?= Mn3ETY5pcWKrdHnvckBw\iCSbHH0[YxmfC2mZYLpeoVlKGe{b4f0bEBn[WO2b4KgdoVk\XC2b4KgbY4hWDF7IHPlcIx{NCCLQ{WwJF0hOC5yMEKg{txONg>? NFz5SYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUe3NVQyQSd-MUW3O|E1OTl:L3G+
P19 cells NUH1RoxqTnWwY4Tpc44h[XO|YYm= M3\G[GlvcGmkaYTpc44hd2ZiUILveIVqdiCNaX7hd4UhSSCrbjDQNVkh[2WubIOsJGlEPTBiPTCwMlAxPCEQvF2u NGHhN3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUe3NVQyQSd-MUW3O|E1OTl:L3G+
P19 cells NXGxcWh7TnWwY4Tpc44h[XO|YYm= M1fVSmlvcGmkaYTpc44hd2ZiQ3HsZ4l2dS:lYXztc4R2dGmwLXTldIVv\GWwdDDwdo91\WmwIHvpcoF{\SC2eYDlJGlKKGmwIGCxPUBk\WyuczygTWM2OCB;IECuNFA3KM7:TT6= M{DWRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{exOFE6Lz5zNUe3NVQyQTxxYU6=
P19 cells NWi0V5JiTnWwY4Tpc44h[XO|YYm= NVz1eXhFUW6qaXLpeIlwdiCxZjDDfYNtcW5vZHXw[Y5l\W62IHvpcoF{\SBzIHnuJHAyQSClZXzsd{whUUN3MDC9JFAvODB6IN88UU4> NGHNdGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUe3NVQyQSd-MUW3O|E1OTl:L3G+
P19 cells MXzGeY5kfGmxbjDhd5NigQ>? MVrJcohq[mm2aX;uJI9nKF[jc3P1cIFzKGWwZH;0bIVtcWGuIHfyc5d1cCCoYXP0c5IhemWlZYD0c5IhcW5iUEG5JINmdGy|LDDJR|UxKD1iMD6wNVQh|ryPLh?= NXe3[HdZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3O|E1OTlpPkG1O|cyPDF7PD;hQi=>
HEK293 cells NXvTZVVrTnWwY4Tpc44h[XO|YYm= M1PrOmlvcGmkaYTpc44hd2ZiSVytPEBz\WynYYPlJIJ6KEiHS{K5N{Bk\WyuczDlfJBz\XO|aX7nJHBMSy2kZYThNkwhUUN3MDC9JFAvODd5IN88UU4> M3jKb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{exOFE6Lz5zNUe3NVQyQTxxYU6=
P19 cells M{HoTWZ2dmO2aX;uJIF{e2G7 MVrJcohq[mm2aX;uJI9nKEmwc4XsbY4hemWlZYD0c5Ihc2mwYYPlJIlvKFBzOTDj[YxteyxiSVO1NEA:KDBwMjFOwG0v M{TaclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{exOFE6Lz5zNUe3NVQyQTxxYU6=
P19 cells NWi4ZXBUTnWwY4Tpc44h[XO|YYm= MVLJcohq[mm2aX;uJI9nKEOjc3XpckBscW6jc3WgNUBqdiCSMUmgZ4VtdHNuIFnDOVAhRSBzLkSg{txONg>? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd5MUSxPUc,OTV5N{G0NVk9N2F-
FL5.12-Akt1 cells NFfSWZFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NV\4XZFGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBHVDVwMUKtRYt1OSClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkK5JO69VS5? NXvTdlQ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NFM3OjZpPkG2OFA{PjJ4PD;hQi=>
MiaPaCa-2 cells NULWeVVFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NEfwUHRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JG1q[VCjQ3GtNkBk\WyuczDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjN5IN88UU4> M4ex[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NECzOlI3Lz5zNkSwN|YzPjxxYU6=
FL5.12-Akt1 cells MkHZSpVv[3Srb36gZZN{[Xl? M1;FO2FkfGm4aYT5JIFo[Wmwc4SgS3NMOyCrbjDGUFUvOTJvQXv0NUBk\WyuczygSWM2OCB;IECuOFYh|ryPLh?= Mn7aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MEO2NlYoRjF4NECzOlI3RC:jPh?=
MiaPaCa-2 cells NUT1XY5HSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M1LadGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTXnhVIFE[S1{IHPlcIx{NCCLQ{WwJF0hOC5|NzFOwG0v M2jlS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEGzO|gxLz5zNkSxN|c5ODxxYU6=
FL5.12-Akt1 cells MVLGeY5kfGmxbjDhd5NigQ>? M4XWXGFkfGm4aYT5JIFo[Wmwc4SgS3NMOyCyaH;zdIhwenmuYYTpc44hcW5iRly1MlEzNUGtdEGgZ4VtdHNuIFXDOVAhRSByLkS2JO69VS5? M{\KflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEGzO|gxLz5zNkSxN|c5ODxxYU6=
Sf21 cells M1[3WGZ2dmO2aX;uJIF{e2G7 MlyyTY5pcWKrdHnvckBw\iCMQVuzJIV5eHKnc4Pl[EBqdiCVZkKxJINmdGy|LDDJR|UxKD1iMD6wNFYh|ryPLh?= NEj6T3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C4PFA2QSd-MUewPFgxPTl:L3G+
U937 cells MVnDfZRwfG:6aXPpeJkh[XO|YYm= NEmyZ|dEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQTN5IHPlcIx{NCCLQ{WwJF0hOiEQvF2u MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB6OEC2O{c,OTdyOEiwOlc9N2F-
Sf9 cells MnLZSpVv[3Srb36gZZN{[Xl? MkTjNUBucW5? M17PeGlvcGmkaYTpc44hd2ZiaIXtZY4hTnmwIHX4dJJme3OnZDDpckBU\jliY3XscJMh[W[2ZYKgNUBucW5iYomgSWxKW0FiaX6gdJJme2WwY3Wgc4YhOSC3bX;sM2whSVSSLDDJR|UxKD1iMD6wNFUh|ryPLh?= MmfsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|MUW4OVMoRjF5M{G1PFU{RC:jPh?=
Sf9 cells MlXYSpVv[3Srb36gZZN{[Xl? NETsZpczOCCvaX7z M{T0fGlvcGmkaYTpc44hd2ZiaIXtZY4hTnmwIHX4dJJme3OnZDDpckBU\jliY3XscJMh[W[2ZYKgNlAhdWmwczDifUBGVEmVQTDpckBxemW|ZX7j[UBw\iBzIIXtc4wwVCCDVGCsJGlEPTBiPTCwMlAyPSEQvF2u NEXtVWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{OxOVg2Oyd-MUezNVU5PTN:L3G+
Sf9 cells NVLa[5VNTnWwY4Tpc44h[XO|YYm= NGLJUWcyKG2rbh?= Ml;PTY5pcWKrdHnvckBw\iCqdX3hckBHgW5iZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bi\nSncjCxJI1qdiCkeTDFUGlUSSCrbjDwdoV{\W6lZTDv[kAyOCC3bX;sM2whSVSSLDDJR|UxKD1iMD6wN|Yh|ryPLh?= NVrveJZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezNVU5PTNpPkG3N|E2QDV|PD;hQi=>
Sf9 cells MYjGeY5kfGmxbjDhd5NigQ>? NEXUVIkzOCCvaX7z NV\nV4FKUW6qaXLpeIlwdiCxZjDoeY1idiCIeX6g[ZhxemW|c3XkJIlvKFOoOTDj[YxteyCjZoTldkAzOCCvaX7zJIJ6KEWOSWPBJIlvKHC{ZYPlcoNmKG:oIEGwJJVud2xxTDDBWHAtKEmFNUCgQUAxNjB6MzFOwG0v MkDFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|MUW4OVMoRjF5M{G1PFU{RC:jPh?=
Sf9 cells MoHzSpVv[3Srb36gZZN{[Xl? MU[xJI1qdg>? MlK4TY5pcWKrdHnvckBw\iCqdX3hckBHgW5iZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bi\nSncjCxJI1qdiCkeTDFUGlUSSCrbjDwdoV{\W6lZTDv[kAyODBidX3vcE9NKEGWUDygTWM2OCB;IECuNlch|ryPLh?= MkfYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|MUW4OVMoRjF5M{G1PFU{RC:jPh?=
Sf9 cells MWHGeY5kfGmxbjDhd5NigQ>? NILUe5czOCCvaX7z MXPJcohq[mm2aX;uJI9nKGi3bXHuJGZ6diCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIFnfGW{IEKwJI1qdnNiYomgSWxKW0FiaX6gdJJme2WwY3Wgc4YhOTByIIXtc4wwVCCDVGCsJGlEPTBiPTCwMlUyKM7:TT6= M1WyWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{G1PFU{Lz5zN{OxOVg2OzxxYU6=
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MDA-MB-231 cells MlTNR5l1d3SxeHnjbZR6KGG|c3H5 MVy3NkBp MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKG2ndHjv[EwhT0l3MDC9JFAvODB5MTFOwG0v MmjZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2OES3O|UoRjF6NEi0O|c2RC:jPh?=
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insect Sf21 cells M4j4SWZ2dmO2aX;uJIF{e2G7 M2jrbmlvcGmkaYTpc44hd2ZiSlHLN{BmgHC{ZYPz[YQhcW5iaX7z[YN1KFOoMkGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCkaX;0bY56dGG2ZXSgd5Vje3S{YYTlJJBpd3OyaH;yfYxifGmxbjygTWM2OCB;IECuNFA3KM7:TT6= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR{N{KwN{c,OTl2MkeyNFM9N2F-
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HeLa cells Mlf2R5l1d3SxeHnjbZR6KGG|c3H5 NVLJTXZ2PDhiaB?= MmjCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4xODByMESg{txONg>? MlTJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|OEixPVEoRjJzM{i4NVkyRC:jPh?=
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MCF7 cells NH7iZmZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{i3UFQ5KGh? M1iwWWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMz6wO{DPxE1w NUXSO2xqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1NFM{PjRpPkKyOVA{OzZ2PD;hQi=>
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MCF7 cells MkLOR5l1d3SxeHnjbZR6KGG|c3H5 Ml;rNlQhcA>? NHfhbXJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFI1KGi{czD1d4lv\yCDbn7lfIlvKF[nRlnUR{9xem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMUig{txONg>? NV\CfIUxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OFExPTFpPkKyOVQyODVzPD;hQi=>
BJ cells M2HsbGN6fG:2b4jpZ4l1gSCjc4PhfS=> MknGO|IhcA>? MnzzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRmoh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPhcINmcW5iQV2gZZN{[XluIFnDOVAhRSByLkCwNkDPxE1w NUflWZQ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NlExQDFpPkKyPVIyODhzPD;hQi=>
CEM cells M3H3fmN6fG:2b4jpZ4l1gSCjc4PhfS=> NEDa[Hk4OiCq NIqz[pFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBETU1iY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNidGOnaX6gRW0h[XO|YYmsJGlEPTBiPTCwMlAzOyEQvF2u MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl{MUC4NUc,OjJ7MkGwPFE9N2F-
MCF7 cells NHHIZVZEgXSxdH;4bYNqfHliYYPzZZk> M320e|czKGh? MlzIR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgR4Ft[2WrbjDBUUBie3OjeTygTWM2OCB;IECuNFY1KM7:TT6= M1nRSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUKxNFgyLz5{MkmyNVA5OTxxYU6=
HeLa cells MWTDfZRwfG:6aXPpeJkh[XO|YYm= NVTsW29NPzJiaB?= NY\oO5NYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA4OiCqcoOgZpkhS2GuY3XpckBCVSCjc4PhfUwhUUN3MDC9JFAvOTd3IN88UU4> NETsN449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyNVA5OSd-MkK5NlExQDF:L3G+
HepG2 cells M{PMc2Z2dmO2aX;uJIF{e2G7 MlHINlQhcA>? MlziTY5pcWKrdHnvckBw\iC2ZXzvcYVz[XOnIHnuJIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDUVmFRNVCFUj3FUGlUSSCjc4PhfUwhUUN3MDC9JFQvOTRizszNMi=> NXX0T4hDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVgxQTZpPkKzNFE5ODl4PD;hQi=>
SW1116 cells NGnWZVdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M3;0WVQ5KGh? NUP4eHEySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|EyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCvZYToc4QtKEmFNUCgQUA1Njl3IN88UU4> NXvpNllERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVgxQTZpPkKzNFE5ODl4PD;hQi=>
HepG2 cells M1HkdGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NVvp[5k5PDhiaB?= NEjqW2lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQhdWW2aH;kMEBKSzVyIE2gOk44OyEQvF2u MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzOEC5Okc,OjNyMUiwPVY9N2F-
BGC823 cells NYDRS4p3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NVXKfIVqPDhiaB?= MorhRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCER1O4NlMh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBu\XSqb3SsJGlEPTBiPTC2Mlg{KM7:TT6= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzOEC5Okc,OjNyMUiwPVY9N2F-
HeLa cells MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NF3IR5E1QCCq M{fZS2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXMZUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJI1mfGixZDygTWM2OCB;IEmuNVIh|ryPLh?= NH;6T2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxPFA6Pid-MkOwNVgxQTZ:L3G+
HCT116 cells MX\GeY5kfGmxbjDhd5NigQ>? NEXG[GJKdmirYnn0bY9vKG:oIGTOTWsudWWmaXH0[YQhXEOIND;i[ZRiNWOjc3XpckB1emGwc3PybZB1cW:wIHnuJIh2dWGwIFjDWFEyPiClZXzsd{BjgSCkZYThMYxi[3SjbXHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwJF0hOC5yM{mg{txONg>? M1n0c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkOyNFYxLz5{M{KzNlA3ODxxYU6=
HepG2 cells MXLGeY5kfGmxbjDhd5NigQ>? NU\keJVkPDhiaB?= M1HhdGlvcGmkaYTpc44hd2ZidHXsc41memG|ZTDpckBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgWHJCWC2SQ2KtSWxKW0FuIFnDOVAhRSB6LkOg{txONg>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ5OUi2OEc,OjN{N{m4OlQ9N2F-
SW1116 cells MoLxSpVv[3Srb36gZZN{[Xl? MUmyOEBp NYL6UohkUW6qaXLpeIlwdiCxZjD0[YxwdWW{YYPlJIlvKGi3bXHuJHNYOTFzNjDj[YxteyCjZoTldkAzPCCqcoOgZpkhXFKDUD3QR3IuTUyLU1GgZZN{[XluIFnDOVAhRSB2LkG4JO69VS5? NHj4OZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK4Olc3OSd-MkSyPFY4PjF:L3G+
KE-97 cells MojuR5l1d3SxeHnjbZR6KGG|c3H5 NIm1RoI4OiCq NEC1TI5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMTS17NzDj[YxteyCjZoTldkA4OiCqcoOgZpkhS2WubGTpeJJmNUeubzDseY1qdmW|Y3XueEBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDBwMUOg{txONg>? NHXoW5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOyPFI5Oyd-MkSzNlgzQDN:L3G+
Jurkat cells M4exW2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2nORlczKGh? NUXjfVhCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUnW{a3H0JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1emVvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6xOEDPxE1w MnfqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MkiyPFMoRjJ2M{K4Nlg{RC:jPh?=
HuH7 cells MXXDfZRwfG:6aXPpeJkh[XO|YYm= M1m5UlczKGh? M4PnSmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh2UDdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTy[U1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjJ|IN88UU4> MljSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MkiyPFMoRjJ2M{K4Nlg{RC:jPh?=
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A2780 cells M3zkemN6fG:2b4jpZ4l1gSCjc4PhfS=> NEXUNoU6PiCq MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNE4zKM7:TT6= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4MUWyNUc,OjR|NkG1NlE9N2F-
HT-29 cells MmCyR5l1d3SxeHnjbZR6KGG|c3H5 M33DUFk3KGh? MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNE4zKM7:TT6= Ml\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|NkG1NlEoRjJ2M{[xOVIyRC:jPh?=
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518A2 cells NYD4bWF1S3m2b4TvfIlkcXS7IHHzd4F6 NXL0XnJJQTZiaB?= M3S3TGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFUyQEF{IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAxNjJizszNMi=> M13i[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{[xOVIyLz5{NEO2NVUzOTxxYU6=
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V79 MZ cells NVTZTlBtTnWwY4Tpc44h[XO|YYm= MXLJcohq[mm2aX;uJI9nKGi3bXHuJIFt\G:|dHXyc45mKHO7boToZZNmKGW6cILld5Nm\CCrbjDWO|khVVpiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBidGSxc4Tldo9v\SC|eX70bIV{cXNuIFnDOVAhRSByLkCxNUDPxE1w NEDmOGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NESyNlUyQSd-MkS0NlI2OTl:L3G+
HEK293 cells M3joNmN6fG:2b4jpZ4l1gSCjc4PhfS=> NF[ydFc4OiCq M17XVmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEiHS{K5N{Bk\WyuczDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{R3zvJIF{e2G7LDDJR|UxKD1iMD6wOVYh|ryPLh?= MonBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5NkOyOlIoRjJ2N{[zNlYzRC:jPh?=
HeLa cells MnHLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MojxNlQhfG9iNEigbC=> MlnyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDJ2IITvJFQ5KGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDJwN{Kg{txONg>? MmLjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5OUK4NVEoRjJ2N{myPFEyRC:jPh?=
A549 cells NEHK[JBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NIjFT|gzPCC2bzC0PEBp NHXtdnFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiMkSgeI8hPDhiaILzJIJ6KEOFSz24JIF{e2G7LDDJR|UxKD1iMz6wOUDPxE1w M2\PW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{myPFEyLz5{NEe5NlgyOTxxYU6=
HepG2 cells NYTnXXRDS3m2b4TvfIlkcXS7IHHzd4F6 NX6zdoFqS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNuIFXDOVAhRSB{IN88UU4> M1zFZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{G2N|E4Lz5{NUOxOlMyPzxxYU6=
Raji cells MnnVR5l1d3SxeHnjbZR6KGG|c3H5 NG\hZppEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBT[WqrIHPlcIx{NCCHQ{WwJF0hOiEQvF2u MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTNzNkOxO{c,OjV|MU[zNVc9N2F-
BJ cells MnjKR5l1d3SxeHnjbZR6KGG|c3H5 MljTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRmoh[2WubIOsJGVEPTBiPTCyJO69VS5? NXXWZlNsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNVY{OTdpPkK1N|E3OzF5PD;hQi=>
HEK293 cells MkjDR5l1d3SxeHnjbZR6KGG|c3H5 MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBJTUt{OUOgZ4VtdHNuIFXDOVAhRSB{IN88UU4> NVS1WXRRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNVY{OTdpPkK1N|E3OzF5PD;hQi=>
A549 cells M3ewdGN6fG:2b4jpZ4l1gSCjc4PhfS=> NWroWmRyPDhiaB?= MojJR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4xOiEQvF2u MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh{NUmzOEc,OjV6MkW5N|Q9N2F-
HeLa cells MVLDfZRwfG:6aXPpeJkh[XO|YYm= M1zKTFQ5KGh? NWjmRVN{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMkWg{txONg>? MmPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MkW5N|QoRjJ3OEK1PVM1RC:jPh?=
PC3 cells MlfoR5l1d3SxeHnjbZR6KGG|c3H5 MlrTOFghcA>? MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNFMyKM7:TT6= MkD3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MkW5N|QoRjJ3OEK1PVM1RC:jPh?=
MGC-803 cells MoT1SpVv[3Srb36gZZN{[Xl? MWmyOEBp MYXJcohq[mm2aX;uJI9nKHSnbH;t[ZJie2ViaX6gbJVu[W5iTVfDMVgxOyClZXzsd{Bi\nSncjCyOEBpenNiYomgWHJCWC2SQ2KtSWxKW0FiYYPzZZktKEmFNUCgQUA5Njl5IN88UU4> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjlyME[1Okc,OjZ7MEC2OVY9N2F-
Sf9 insect cells M1KweGZ2dmO2aX;uJIF{e2G7 MlG4NVAhdWmwcx?= MX7Jcohq[mm2aX;uJI9nKE5vdHXycYlv[WxiR2PUJJRi\2enZDDy[YNwdWKrbnHueEBnfWyuLXzlcod1cCCqdX3hckBEUEtzIHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCVZkmgbY5{\WO2IHPlcIx{KGGodHXyJFExKG2rboOgZpkhdHWvaX7ld4NmdnRiQVTQMWdtdyCjc4PhfUwhUUN3MDC9JFAvODBzMjFOwG0v NHLUe3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C4PVIyOSd-MkewPFkzOTF:L3G+
Sf21 cells M1\YRmZ2dmO2aX;uJIF{e2G7 NUHxV|dmPjBibXnudy=> M2\sRmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSlHLNkBmgHC{ZYPz[YQhcW5iU3[yNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iVXzp[4h1NUODR1HHRWlGXESNRWnZWHZMTCCyaH;zdIhwenmuYYTpc44heHKnLXnuZ5Vj[XSnZDDi[YZwemVic4Xid5Rz[XSnIHHk[Il1cW:wIHHu[EBu\WG|dYLl[EBi\nSncjC2NEBucW6|IHL5JGxCVkOHIHTleIVkfGmxbjDt[ZRpd2RuIFnDOVAhRSByLkCwNkDPxE1w MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF|N{O1PUc,OjdzM{ezOVk9N2F-
Neuro2a cells NXqzdGVHS3m2b4TvfIlkcXS7IHHzd4F6 NYrNS|JCPzJiaB?= NHPyPFNEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBP\XW{b{LhJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkCxNVMh|ryPLh?= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF3MkSyO{c,OjhzNUK0Nlc9N2F-
MDA-MB-231 cells MkG0SpVv[3Srb36gZZN{[Xl? NG\2fVMyPiCq MkjSTY5pcWKrdHnvckBw\iC{ZYTpco9jdGG|dH;tZUBxem:2ZXnuJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDF4IHjyd{BjgSCKb3XjbJN1KDN|M{SyJJN1[WmwaX7nJIJie2WmIH\seY9z\XOlZX7j[UBie3OjeTygTWM2OCB;IECuNFY3KM7:TT6= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR|MUO0Nkc,Ojh2M{GzOFI9N2F-
Sf9 insect cells NEHyUmNHfW6ldHnvckBie3OjeR?= Mm\tNlAhdWmwcx?= NFviVGNKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIF6teIVzdWmwYXzsfUBIW1RvdHHn[4VlKEWJRmKgUFg2QFJxVEe5NG0wSzd7N2OgeJJqeGynIH31eIFvfCCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW5iU3[5JIlve2WldDDj[YxteyCycnXpcoN2[mG2ZXSg[o9zKDJyIH3pcpMh\m:ubH;3[YQh[nliYXTkbZRqd25ib3[gX|M{WF1vQWTQJI1m[XO3cnXkJIFnfGW{IEKgbJJ{KGK7IH\pcJRmei2kaX7kbY5oKG2ndHjv[EwhUUN3MDC9JFAvODByMkmg{txONg>? NU\EZ2ljRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0PFIyPTFpPkK4OFgzOTVzPD;hQi=>
HEK293 cells NEPZR4dEgXSxdH;4bYNqfHliYYPzZZk> NWXMTFdVPzJiaB?= MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncjDHcI8hdHWvaX7ld4NmdnRiYYPzZZktKEOFNUCgQUAxNjByM{W0JO69VS5? MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ{NEewNUc,Ojh4MkS3NFE9N2F-
BT549 cells NYPLR2NuS3m2b4TvfIlkcXS7IHHzd4F6 MVOyOEBp MoTiR5l1d3SxeHnjJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQmS1OFkh[2WubIOgbY5kfWKjdHXkJIZweiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6wPEDPxE1w NGTkdpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEewOVQ{Oid-Mki3NFU1OzJ:L3G+
MDA-MB-468 cells Ml\CR5l1d3SxeHnjbZR6KGG|c3H5 NGLIXIUzPCCq NWLUSIJMS3m2b4TvfIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUS2PEBk\WyuczDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkG1JO69VS5? MkjPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MEW0N|IoRjJ6N{C1OFMzRC:jPh?=
MDA-MB-231 cells NXvYOVVUS3m2b4TvfIlkcXS7IHHzd4F6 M2jJWlI1KGh? NY\SeoduS3m2b4TvfIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkK0JO69VS5? NFfX[|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEewOVQ{Oid-Mki3NFU1OzJ:L3G+
Vero cells MVTDfZRwfG:6aXPpeJkh[XO|YYm= Ml;zNkBl[Xm| M13R[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFIh\GG7czDifUBk\WyuLYTpeIVzNWeubzDseY1qdmW|Y3XueEBie3OjeTygWGM2OCB;IECuNFAzPCEQvF2u NY\0TWJWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OlM3PDVpPkK4O|Y{PjR3PD;hQi=>
L929 cells M3XBWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MkK1OUBl[Xm| NVXkNm5uSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDMPVI6KGOnbHzzJIFnfGW{IEWg[IF6eyCkeTDXV3QuOSCjc4PhfUwhUUN3MDC9JFAvOiEQvF2u Ml23QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NU[5NVUoRjJ6OUW2PVE2RC:jPh?=
KB-3-1 cells MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M1;sRlUh\GG7cx?= MljsRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNQj2zMVEh[2WubIOgZYZ1\XJiNTDkZZl{KGK7IGfTWE0yKGG|c3H5MEBKSzVyIE2gNE4zKM7:TT6= NFj2fnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkyPSd-Mki5OVY6OTV:L3G+
MCF7 cells M1TCbWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MoXROUBl[Xm| NHqySXNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNTDkZZl{KGK7IGfTWE0yKGG|c3H5MEBKSzVyIE2gNU45KM7:TT6= NI\rdmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkyPSd-Mki5OVY6OTV:L3G+
FS4-LTM cells NXS5[YxOSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NVvPRW5vOjRiaB?= NVTVT5FOSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDGV|QuVFSPIHPlcIx{KGGodHXyJFI1KGi{czDifUBYW1RvMTDhd5NigSxiSVO1NEA:KDJwODFOwG0v M33HOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUW2PVE2Lz5{OEm1OlkyPTxxYU6=
Vero cells NFfz[YJEgXSxdH;4bYNqfHliYYPzZZk> NX;aWm16OiCmYYnz MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHmeIVzKDJiZHH5d{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6wNFI1KM7:TT6= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl7M{GwOkc,Ojh7OUOxNFY9N2F-
HepG2 cells NULqNnhmS3m2b4TvfIlkcXS7IHHzd4F6 NHrWNJAyODBidV2= MVezJIRigXN? NVLWfXJ[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYSgNVAxKHWPIHHmeIVzKDNiZHH5d{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6wNVgh|ryPLh?= NXX5OFZWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5PVMyODZpPkK4PVk{OTB4PD;hQi=>
NIH/3T3 cells NWLW[YVRS3m2b4TvfIlkcXS7IHHzd4F6 MoXKPVYhcA>? Mnn5R5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgUmlJNzOWMzDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCHQ{WwJF0hOC5yMEig{txONg>? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF7N{ezNEc,OjlzOUe3N|A9N2F-
518A2 cells NG\mTY9EgXSxdH;4bYNqfHliYYPzZZk> NX7BUnNDQTZiaB?= M{DFbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFUyQEF{IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEWFNUCgQUAxNjB|IN88UU4> MlHSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzOUe3N|AoRjJ7MUm3O|MxRC:jPh?=
A549 cells NWjZU|ZpS3m2b4TvfIlkcXS7IHHzd4F6 MWm5OkBp NYrTZnhPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCHQ{WwJF0hOC5yNDFOwG0v M4XZO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUm3O|MxLz5{OUG5O|c{ODxxYU6=
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A2780 cells M4HGfGN6fG:2b4jpZ4l1gSCjc4PhfS=> NFHw[lM6PiCq MkLaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVI4QDBiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhTUN3MDC9JFAvOTJizszNMi=> NYfJ[ldKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxPVc4OzBpPkK5NVk4PzNyPD;hQi=>
HT-29 cells MnjpR5l1d3SxeHnjbZR6KGG|c3H5 MnvQPVYhcA>? NGX1O4xEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCHQ{WwJF0hOC5zNTFOwG0v MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF7N{ezNEc,OjlzOUe3N|A9N2F-
PC3 cells Mn3lR5l1d3SxeHnjbZR6KGG|c3H5 NGnpZmREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3MDC9JFAvODF5IN88UU4> NI\DSXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUO4PVEzOid-MkmzPFkyOjJ:L3G+
HCT116 cells M1vPZWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYLPSZlPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFnDOVAhRSByLkC1OUDPxE1w NEizSoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUO4PVEzOid-MkmzPFkyOjJ:L3G+
insect cells MWPGeY5kfGmxbjDhd5NigQ>? NGrjSnE{OCCvaX7z MV;Jcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKFCGR1\SZoV1[SCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KHW|aX7nJHVtcWeqdD3Qc4x6KEeDVGvFRXkpOTpzOkGpYY4h[XNic4Xid5Rz[XSnIHHmeIVzKDNyIH3pcpMh[nliTFHOR2UhdWW2aH;kMEBKSzVyIE2gNE4xODB5NjFOwG0v Mn3UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NEm4N|YoRjJ7NUS5PFM3RC:jPh?=
Sf9 insect cells NXry[INUTnWwY4Tpc44h[XO|YYm= NV3vSVlNPjBibXnudy=> MX7Jcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKEuGUjDlfJBz\XO|ZXSgbY4hW2Z7IHnud4VkfCClZXzsd{B2e2mwZzDVcIlocHRvQ1HHRWdCUUWWRFvFXXlVXkuGIHHzJJN2[nO2cnH0[UBi\nSncjC2NEBucW6|IHL5JGxCVkOHIH3leIhw\CxiSVO1NEA:KDBwMECyNUDPxE1w NWnmRmVURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
insect cells NX24[5ZQTnWwY4Tpc44h[XO|YYm= MXKxNEBucW6| MmfVTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCVcnOg[ZhxemW|c3XkJIlvKGmwc3XjeEBk\WyuczD1d4lv\yCXbHnnbJQuWG:ueTDHRXRcTUG\KEG6NVoyMV2wIHHzJJN2[nO2cnH0[UBi\nSncjCxNEBucW6|IHL5JGxCVkOHIH3leIhw\CxiSVO1NEA:KDBwMEC1JO69VS5? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2OUizOkc,Ojl3NEm4N|Y9N2F-
insect cells NXnCS2EzTnWwY4Tpc44h[XO|YYm= NVj2W2RMOTVibXnudy=> MUjJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKEOGS{GvR5lkdGmwIFKg[ZhxemW|c3XkJIlvKGmwc3XjeEBk\WyuczD1d4lv\yCXbHnnbJQuS0[IS17JWnRRWlSSUGDTVWdMNWGvaXTlJIF{KHO3YoP0doF1\SCjZoTldkAyPSCvaX7zJIJ6KEyDTlPFJI1mfGixZDygTWM2OCB;IECuNFI2KM7:TT6= NVPsfIk5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
insect cells MoLLSpVv[3Srb36gZZN{[Xl? NWTvTW9vOTVibXnudy=> NVzxPIgzUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDDSGsyN0O7Y3zpckBDKGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMhfXOrbnegWYxq\2i2LVPGSmtPUV[WUGLUVHBRW1GJSz3hcYll\SCjczDzeYJ{fHKjdHWgZYZ1\XJiMUWgcYlveyCkeTDMRW5ETSCvZYToc4QtKEmFNUCgQUAxNjB{NTFOwG0v Mn21QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NEm4N|YoRjJ7NUS5PFM3RC:jPh?=
Sf9 insect cells M2nPUGZ2dmO2aX;uJIF{e2G7 NF\jXngyPSCvaX7z MWTJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKE[udEGg[ZhxemW|c3XkJIlvKFOoOTDpcpNm[3RiY3XscJMhfXOrbnegWYxq\2i2LWTLJJBmeHSrZHWgZZMhe3Wkc4TyZZRmKGGodHXyJFE2KG2rboOgZpkhVEGQQ1WgcYV1cG:mLDDJR|UxKD1iMD6wN|Uh|ryPLh?= MlXQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NEm4N|YoRjJ7NUS5PFM3RC:jPh?=
Sf21 insect cells M1TPfmZ2dmO2aX;uJIF{e2G7 MXexOUBucW6| NFXH[nlKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIFH1do9z[S2DIHX4dJJme3OnZDDpckBU\jJzIHnud4VkfCClZXzsd{B2e2mwZzDVcIlocHRvUmLSV2xNTSCjczDzeYJ{fHKjdHWgZYZ1\XJiMUWgcYlveyCkeTDMRW5ETSCvZYToc4QtKEmFNUCgQUAxNjB|OTFOwG0v NXHzTGlqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
insect cells NELkZpJHfW6ldHnvckBie3OjeR?= NGDNfJY3OCCvaX7z MlXJTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCDS2SxJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgeZNqdmdiQ2LFRpRq\GViYYOgd5Vje3S{YYTlJIFnfGW{IE[wJI1qdnNiYomgUGFPS0VibXX0bI9lNCCLQ{WwJF0hOC5yNU[g{txONg>? NYTHR|lVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
Sf9 insect cells M2SxU2Z2dmO2aX;uJIF{e2G7 MYi2NEBucW6| MWfJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKE[DSzDlfJBz\XO|ZXSgbY4hW2Z7IHnud4VkfCClZXzsd{B2e2mwZzDVcIlocHRvVFugdIVxfGmmZTDhd{B{fWK|dILheIUh[W[2ZYKgOlAhdWmwczDifUBNSU6FRTDt[ZRpd2RuIFnDOVAhRSByLkC2NkDPxE1w M4fjV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS5PFM3Lz5{OUW0PVg{PjxxYU6=
insect cells NEOwZppHfW6ldHnvckBie3OjeR?= NHWycYY3OCCvaX7z NVixeZFKUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDBRmwh\XiycnXzd4VlKGmwIHnud4VkfCClZXzsd{B2e2mwZzDVcIlocHRvVFugdIVxfGmmZTDhd{B{fWK|dILheIUh[W[2ZYKgOlAhdWmwczDifUBNSU6FRTDt[ZRpd2RuIFnDOVAhRSByLkK5JO69VS5? NFHXdno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW0PVg{Pid-Mkm1OFk5OzZ:L3G+
insect cells M37NWGZ2dmO2aX;uJIF{e2G7 MkHBOlAhdWmwcx?= MYXJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKGNvTVXUJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgeZNqdmdiVXzp[4h1NUODR1HHRWlGXESNRWnZWHZMTCCjczDzeYJ{fHKjdHWgZYZ1\XJiNkCgcYlveyCkeTDMRW5ETSCvZYToc4QtKEmFNUCgQUAxNjNzIN88UU4> NWrhWHhSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
PC3 cells NF7MUXlEgXSxdH;4bYNqfHliYYPzZZk> MVm3NkBp M1jENWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNE4xOzlizszNMi=> NFnMOHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW1PFEyQSd-Mkm1OVgyOTl:L3G+
Sf9 cells NEDuVWxHfW6ldHnvckBie3OjeR?= NIHjV|E1PSCvaX7z MnvqTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCFLYTldo1qdmGuIFjpd{11[WepZXSvUk11\XKvaX7hcEBIW1RvdHHn[4VlKEWJRmKgLFY3QCC2bzCxNlExKHKnc3nkeYV{MSCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhW2Z7IHPlcIx{KHW|aX7nJHBwdHlvKFfseUwhXHm{KTDhd{B{fWK|dILheIUhdWWjc4Xy[YQh[W[2ZYKgOFUhdWmwdYTld{BjgSCNaX7hd4UuT2yxIHz1cYlv\XOlZX70JIF{e2G7LDDJR|UxKD1iMD6wOFch|ryPLh?= NW\NcJB5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NFI4OTlpPkK5PVAzPzF7PD;hQi=>
Sf9 cells Mn;DSpVv[3Srb36gZZN{[Xl? NWL3dWliPDVibXnudy=> M{TJVmlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgbJVu[W5iTj30[ZJucW6jbDDHV3QufGGpZ3XkJGhGWjJiKE[3PUB1dyBzMkW1JJJme2mmdXXzLUBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgV4Y6KGOnbHzzJJV{cW6pIGDvcJkuMEeudTygWJlzMSCjczDzeYJ{fHKjdHWgcYVie3W{ZXSgZYZ1\XJiNEWgcYlvfXSnczDifUBMcW6jc3WtS4xwKGy3bXnu[ZNk\W62IHHzd4F6NCCLQ{WwJF0hOC5yNkC4JO69VS5? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTlyMkexPUc,Ojl7MEK3NVk9N2F-
HT-29 cells Mn3hSpVv[3Srb36gZZN{[Xl? NHfsOnc{KGh? NG\hO3ZKdmirYnn0bY9vKG:oIH3peI9kcG:wZILpZYwhdWWvYoLhcoUheG:2ZX70bYFtKGmwIHj1cYFvKEiWLUK5JINmdGy|IHHmeIVzKDNiaILzJIJ6KEqFLUGgd5RicW6rbnegZoF{\WRiZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxKD1iMD6wNkDPxE1w NVnHNol7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOVcyPTVpPkOwNFU4OTV3PD;hQi=>
Sf9 cells Mk\2SpVv[3Srb36gZZN{[Xl? M4Dz[WlvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDGUGFINXSjZ3fl[EBpfW2jbjDmeYxtNWynbnf0bEBETEtzMjCoNUB1dyBzNEmwJJJme2mmdXXzLU9PNXSncn3pcoFtKEircz30ZYdo\WRiQ4njT{ApOSC2bzC1PFAhemW|aXT1[ZMqKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIFHUVE1l\XCnbnTlcpQhXUyrZ3j0MVRGNUKSMTCoWIhzOzdxVHjyOFYqKHO3YoP0doF1\SCyZYD0bYRmKHCqb4PwbI9zgWyjdHnvckBxeixiSVO1NEA:KDBwMEWzJO69VS5? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB4N{O1PEc,OzByNkezOVg9N2F-
Sf9 cells NXm1UlRkTnWwY4Tpc44h[XO|YYm= NX7aTo81UW6qaXLpeIlwdiCxZjDOMZRmem2rbnHsJGZNSUdvdHHn[4VlKGi3bXHuJIZ2dGxvbHXu[5RpKEOGS{GyJEgyKHSxIEG0PVAhemW|aXT1[ZMqN05vdHXycYlv[WxiSHnzMZRi\2enZDDDfYNMKChzIITvJFU5OCC{ZYPp[JVmeyliZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gRXRRNWSncHXu[IVvfCCXTHnnbJQuPEVvQmCxJEhVcHJ|Nz;UbJI1Pilic4Xid5Rz[XSnIIDldJRq\GVicHjvd5Bpd3K7bHH0bY9vKHC{LDDJR|UxKD1iMD6wOVMh|ryPLh?= M4[yTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyME[3N|U5Lz5|MEC2O|M2QDxxYU6=
Sf9 cells NEPwVlRHfW6ldHnvckBie3OjeR?= M1rROmlvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDGUGFINXSjZ3fl[EBpfW2jbjDmeYxtNWynbnf0bEBETEtzMzCoNUB1dyBzNUGyJJJme2mmdXXzLU9PNXSncn3pcoFtKEircz30ZYdo\WRiQ4njT{ApOSC2bzC1PFAhemW|aXT1[ZMqKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIFHUVE1l\XCnbnTlcpQhXUyrZ3j0MVRGNUKSMTCoWIhzOzdxVHjyOFYqKHO3YoP0doF1\SCyZYD0bYRmKHCqb4PwbI9zgWyjdHnvckBxeixiSVO1NEA:KDBwMEW3JO69VS5? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB4N{O1PEc,OzByNkezOVg9N2F-
Sf9 cells MXrGeY5kfGmxbjDhd5NigQ>? NU\5c5h7UW6qaXLpeIlwdiCxZjDOMZRmem2rbnHsJGZNSUdvdHHn[4VlKGi3bXHuJIZ2dGxvbHXu[5RpKEOGS{GzJEgyKHSxIEG1NVIhemW|aXT1[ZMqN05vdHXycYlv[WxiSHnzMZRi\2enZDDDfYNMKChzIITvJFU5OCC{ZYPp[JVmeyliZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gRXRRNWSncHXu[IVvfCCXTHnnbJQuPEVvQmCxJEhVcHJ|Nz;UbJI1Pilic4Xid5Rz[XSnIIDldJRq\GVicHjvd5Bpd3K7bHH0bY9vKHC{LDDJR|UxKD1iMD6wOVch|ryPLh?= NX;LS5NMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOlc{PThpPkOwNFY4OzV6PD;hQi=>
HCT116 cells NVqwe2JNS3m2b4TvfIlkcXS7IHHzd4F6 M2jidlQ5KGh? M2nabWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6wN{DPxE1w M4C4ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUC2NlkyLz5|MEGwOlI6OTxxYU6=
Huh7.5 cells NUPpOm1SS3m2b4TvfIlkcXS7IHHzd4F6 NH\6NI01QCCq MYTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIeYg4NjViY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwNjFOwG0v NYnKTY1oRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxNFYzQTFpPkOwNVA3OjlzPD;hQi=>
K562 cells NEDNZlFEgXSxdH;4bYNqfHliYYPzZZk> NHrvUYM1QCCq NWPmOHNkS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMT63JO69VS5? M17USFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUC2NlkyLz5|MEGwOlI6OTxxYU6=
LO2 cells MX3DfZRwfG:6aXPpeJkh[XO|YYm= NHnsXGU1QCCq M4nHbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxQOiClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS53IN88UU4> NGntPYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEGwOlI6OSd-M{CxNFYzQTF:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-Akt / Akt / PARP /Cleaved PARP; 

PubMed: 24174874     


Western blot analysis for Akt, P-Akt, and cleaved poly(ADP-ribose) polymerase. U87 cells were incubated with 200 nM, 10 nM, and 0.1 nM of staurosporine encapsulated in liposomes and staurosporine for 32 hours.

FAK / RIP; 

PubMed: 15121855     


Western blot (WB) analysis of BT-20 and BT-474 lysates treated with staurosporine (200 nM). Control cells were treated with dimethyl sulfoxide for 18 h.

Ambra1; 

PubMed: 24587252     


SW620 cells treated with various doses of staurosporine for 6 h. Ambra1 levels were measured by Western blot. 

24174874 15121855 24587252
Growth inhibition assay
Cell viability; 

PubMed: 25215174     


Staurosporine reduces cerebellar astrocytes viability. (a) Cerebellar astrocytes were treated with staurosporine 0.1 μM, 0.25 μM, and 0.5 μM for 24 h and the cell viability was measured by MTT transformation. (b) Cerebellar astrocytes were treated with staurosporine 0.5 μM for 6, 12, and 24 h and the cell viability was measured by MTT transformation. Data are presented as mean ± SEM of four independent experiments. ∗ is significantly different from control (P < 0.05).

25215174
Immunofluorescence
Tubulin / Actin; 

PubMed: 25215174     


Morphological changes of astrocytes induced by St are evidenced by the rearrangement of cytoskeletal proteins. Astrocytes were treated with St (0.5 μM) for 12 hours and then were labelled with rhodamine-phalloidin or immunostained for tubulin. Representative images of phase contrast, rhodamine-phalloidin, and tubulin are shown in control and St treated astrocytes. Scale bar represents 50 μm.

Phalloidin / Type II collagen; 

PubMed: 22684244     


Cell were cultured in the absence (a-f) or presence of staurosporine (STSN, 5 × 10-9M) or cytochalasin D (CD, 1 µg/ml) for 1 (upper panel) or 2 (lower panel) days at low density and stained for F-actin (Phalloidin) and type II collagen (Type II). STSN: Staurosporine.

Pyk2; 

PubMed: 19880522     


Pyk2 translocates to the nucleus upon staurosporine addition to ID8 cells. Confocal immunofluorescent analysis of endogenous Pyk2 upon DMSO (control) or 1 μm staurosporine addition for 2 h. The scale bar is 10 μm. 

Annexin; 

PubMed: 15140398     


Induction of apoptosis with staurosporine resulting in activation of the ICE-NIRF probe. Gli36 cells were treated with 50 µM staurosporine for 24 hours (A-C) or with the same percentage of DMSO (0.01%) to which experimental wells were exposed (D-488nm laser, E-633nm laser and F-bright field). To examine the role of caspase-1 in staurosporine-induced apoptosis and probe activation, cells were coincubated in caspase-1 inhibitor (10 µM) and staurosporine (G-I). Staurosporine induces apoptosis, indicated by the positive annexin staining viewed with the 488-nm laser (A), which colocalized with activated probe viewed with the 633-nm laser (B). Coincubation of the caspase-1 inhibitor with staurosporine did not completely block apoptosis, indicated by the relatively higher number of apoptotic cells stained with annexin (G), as those that activated the probe (H). Magnification, x 40; scale bar, 50 µM.

cleaved-caspase 3; 

PubMed: 19840952     


Representative images (×1000 magnification) showing vehicle treated (C) and staurosporine treated (D) cells stained with anti-cleaved caspase 3 antibody and DAPI.

FAK 4.47; 

PubMed: 15121855     


BT-20 or BT-474 cell culture were plated on six-well plates and were treated with staurosporine (200 nM) after 24 h. After 6 h of treatment, cells were immunostained with anti-FAK 4.47 antibody (white arrowheads mark some focal adhesions).

25215174 22684244 19880522 15140398 19840952 15121855
In vivo In the gerbil and rat ischemia models, Staurosporine pretreatment (0.1-10 ng) before ischemia prevents neuronal damage in a dose-dependent manner, suggesting the involvement of PKC in CAl pyramidal cell death after ischemia. [8]

Protocol

Kinase Assay:

[1]

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Enzyme assay and binding assay:

Protein kinase C is assayed in a reaction mixture (0.25 mL) containing 5 μmol of Tris/HCl, pH 7.5, 2.5 μmol of magnesium acetate, 50 μg of histone II S, 20 μg of phosphatidylserine, 0.88 μg of diolein, 125 nmol of CaCl2, 1.25 nmol of [γ-32]ATP (5-10 × 104 cpm/nmol) and 5 μg of partially purified enzyme. The binding of [3H]PDBu to protein kinase C is determined: Reaction mixture (200 μL contained 4 μmo1 of Tris/malate, pH 6.8, 20 μmol of KCl, 30 nmol of CaC12, 20 μg of phosphatidylserine, 5 μg of partially purified protein kinase C, 0.5% (final concentration) of DMSO,10 pmol of [3H]PDBu (l-3 × 104 cpm/pmol) and 10 μL of various amounts of Staurosporine.
Cell Research:

[3]

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  • Cell lines: PC12
  • Concentrations: Dissolved in DMSO, final concentration 1 μM
  • Incubation Time: ~32 hours
  • Method:

    Cells are exposed to Staurosporine for ~32 hours. Cells are fixed in 4% paraformaldehyde and stained with the DNA-binding dye Hoechst 33342. Cells are visualized under epifluorescence illumination, and the percentage of apoptotic cells (cells with condensed and fragmented DNA) is determined.


    (Only for Reference)
Animal Research:

[8]

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  • Animal Models: Male Mongolian gerbils or male Wistar rats subjected to transient ischemia
  • Dosages: ~10 ng
  • Administration: Stereotaxically administered into the bilateral CAl subfield of the hippocampus
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL (8.57 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 466.53
Formula

C28H26N4O3

CAS No. 62996-74-1
Storage powder
in solvent
Synonyms CGP 41251
Smiles CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID