Staurosporine (AM-2282)

For research use only.

Catalog No.S1421 Synonyms: Antibiotic AM-2282, STS

91 publications

Staurosporine (AM-2282) Chemical Structure

CAS No. 62996-74-1

Staurosporine (AM-2282, Antibiotic AM-2282, STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.

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Selleck's Staurosporine (AM-2282) has been cited by 91 publications

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Biological Activity

Description Staurosporine (AM-2282, Antibiotic AM-2282, STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.
Targets
PKCα [1]
(Cell-free assay)
c-Fgr [2]
(Cell-free assay)
phosphorylase kinase [2]
(Cell-free assay)
PKCη [1]
(Cell-free assay)
PKCγ [1]
(Cell-free assay)
2 nM 2 nM 3 nM 4 nM 5 nM
In vitro

Staurosporine, a microbial alkaloid, significantly inhibits protein kinase C from rat brain with IC50 of 2.7 nM. Staurosporine displays strong inhibitory effect against HeLa S3 cells with IC50 of 4 nM. [1] Staurosporine also inhibits a variety of other protein kinases, including PKA, PKG, phosphorylase kinase, S6 kinase, Myosin light chain kinase (MLCK), CAM PKII, cdc2, v-Src, Lyn, c-Fgr, and Syk with IC50 of 15 nM, 18 nM, 3 nM, 5 nM, 21 nM, 20 nM, 9 nM, 6 nM, 20 nM, 2 nM, and 16 nM, respectively. [2] Staurosporine (1 μM) induces >90% apoptosis in PC12 cells. Consistently, Staurosporine treatment induces a rapid and prolonged elevation of intracellular free calcium levels [Ca2+]i, accumulation of mitochondrial reactive oxygen species (ROS), and subsequent mitochondrial dysfunction. [3] The apoptosis of MCF7 cells induced by Staurosporine can be enhanced by the expression of functional caspase-3 via caspase-8 activation and Bid cleavage. [4] Staurosporine treatment at 1 μM only partially inhibits IL-3-stimulated Bcl2 phosphorylation but completely blocks PKC-mediated Bcl2 phosphorylation. [5] Staurosporine induces apoptosis of human foreskin fibroblasts AG-1518, depending on the lysosomal cathepsins D mediated cytochrome c release and caspase activation. [6] In addition to activating the classical mitochondrial apoptosis pathway, Staurosporine triggers a novel intrinsic apoptosis pathway, relying on the activation of caspase-9 in the absence of Apaf-1. [7]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human colon carcinoma cell line HCT116 NIDEVXBHfW6ldHnvckBie3OjeR?= NYfT[GZqS2:wY3XueJJifGmxbjDy[ZF2cXKnZDDmc5Ih\3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4h[2:ub36gZ4Fz[2mwb33hJINmdGxibHnu[UBJS1RzMU[sJGlEPTB;NjDuUU4> M{O2ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUO3N|Q2Lz5zNUWzO|M1PTxxYU6=
human PBMC Mn70SpVv[3Srb36gZZN{[Xl? NF;TSYMzPCCq NFzSc5hUfXCycnXzd4lwdiCxZjDJUFIheHKxZIXjeIlwdiCrbjDoeY1idiCSQl3DJIFnfGW{IEK0JIhzeyCkeTDFUGlUSSxiSVO1NF0yPiCwTT6= NGnwb249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW4OVA1Pid-MUi1PFUxPDZ:L3G+
endothelial cells NWnMZ3hWTnWwY4Tpc44h[XO|YYm= M17oOmVn\mWldHn2[UBld3OnIHHnZYlve3RicHzhd41qdm:pZX6gZYN1cX[jdH;yJIFkfGm4aYT5JJN1cW23bHH0[YQh[nlicHjvdoJwdCCnc4TldkBqdiCnbnTveIhmdGmjbDDj[YxteyxiRVS1NEA:KDdwNTFOwG0v NUfYdFBURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEewPVA6PSd-OEewPVA6PTxxYU6=
Sf9 insect cells NY[1TVl6TnWwY4Tpc44h[XO|YYm= NGfFPYNKdmirYnn0bY9vKG:oIIDyc5RmcW5ia3nuZZNmKENqMUqxcYl5fHW{ZTDv[kBRU0NiYXzwbIEhLiCkZYThLUBmgHC{ZYPz[YQhcW5iU3[5JIlve2WldDDj[YxteyxiSVO1NEA:KDBwMEKg{txONg>? M2\UTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl6N{O2NFUoRjl6N{O2NFU9N2F-
LoVo cells MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKGOxbH;uJINidmOncjDj[YxtKGyrbnWgLGxwXm9iY3XscJMqKHW|aX7nJG1VXCCjc4PhfUwhUUN3MDC9JFAvODBzIN88UU4> NIW1UFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUW5NVUxPSd-MUG1PVE2ODV:L3G+
umbilical vein endothelial cells M2LxV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M2LZ[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5idX3ibYxq[2GuII\lbY4h\W6mb4To[Yxq[WxiY3XscJMhMEiXVlXDd{khfXOrbnegUXRVKGG|c3H5MEBKSzVyIE2gNE4xODRizszNMi=> MkjpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF3OUG1NFUoRjFzNUmxOVA2RC:jPh?=
ST-486 cells NYnQbWZsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHL1dotqfCCueX3wbI9u[SClZXzsJIxqdmViKGPUMVQ5PiClZXzsd{khfXOrbnegUXRVKGG|c3H5MEBKSzVyIE2gNE4xODdizszNMi=> M{Hoe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNUmxOVA2Lz5zMUW5NVUxPTxxYU6=
DLD-1 cells MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NYTiephVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubDDsbY5mKCiGTFStNUBk\WyuczmgeZNqdmdiTWTUJIF{e2G7LDDJR|UxKD1iMD6wNFkh|ryPLh?= M2LaPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNUmxOVA2Lz5zMUW5NVUxPTxxYU6=
HEK293 cells NUPjbIE4TnWwY4Tpc44h[XO|YYm= MnfLTY5pcWKrdHnvckBw\iCSS1OtZoV1[SCLSTDt[YRq[XSnZDDJUE05KHKnbHXhd4Uh\nKxbTDISWszQTNiY3XscJMh[nliRVzJV2EtKEmFNUCgQUAxNjB5NzFOwG0v MmrXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ7NEGzN|EoRjF{OUSxN|MyRC:jPh?=
P19 cells NWHuPGZETnWwY4Tpc44h[XO|YYm= MUDJcohq[mm2aX;uJI9nKFCuYYTlcIV1NWSncnn2[YQh\3Kxd4ToJIZi[3SxcjDy[YNmeHSxcjDpckBROTliY3XscJMtKEmFNUCgQUAxNjByMjFOwG0v MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd5MUSxPUc,OTV5N{G0NVk9N2F-
P19 cells NXrWU2NrTnWwY4Tpc44h[XO|YYm= MlTVTY5pcWKrdHnvckBw\iCSbHH0[YxmfC2mZYLpeoVlKGe{b4f0bEBn[WO2b4KgdoVk\XC2b4KgbY4hWDF7IHPlcIx{NCCLQ{WwJF0hOC5yMEKg{txONg>? M3[5PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{exOFE6Lz5zNUe3NVQyQTxxYU6=
P19 cells M1LpNGZ2dmO2aX;uJIF{e2G7 MUnJcohq[mm2aX;uJI9nKFC{b4TlbY4hU2mwYYPlJGEhcW5iUEG5JINmdGy|LDDJR|UxKD1iMD6wNFQh|ryPLh?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd5MUSxPUc,OTV5N{G0NVk9N2F-
P19 cells MVLGeY5kfGmxbjDhd5NigQ>? M4PvemlvcGmkaYTpc44hd2ZiQ3HsZ4l2dS:lYXztc4R2dGmwLXTldIVv\GWwdDDwdo91\WmwIHvpcoF{\SC2eYDlJGlKKGmwIGCxPUBk\WyuczygTWM2OCB;IECuNFA3KM7:TT6= NGrYWpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUe3NVQyQSd-MUW3O|E1OTl:L3G+
P19 cells MnHvSpVv[3Srb36gZZN{[Xl? NFSzfHlKdmirYnn0bY9vKG:oIFP5Z4xqdi2mZYDlcoRmdnRia3nuZZNmKDFiaX6gVFE6KGOnbHzzMEBKSzVyIE2gNE4xODhizszNMi=> NVTMOI17RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3O|E1OTlpPkG1O|cyPDF7PD;hQi=>
P19 cells NWG0NlhWTnWwY4Tpc44h[XO|YYm= NGLUUG9KdmirYnn0bY9vKG:oIG\hd4N2dGG{IHXu[I91cGWuaXHsJIdzd3e2aDDmZYN1d3JicnXj[ZB1d3JiaX6gVFE6KGOnbHzzMEBKSzVyIE2gNE4xOTRizszNMi=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd5MUSxPUc,OTV5N{G0NVk9N2F-
HEK293 cells Mm\YSpVv[3Srb36gZZN{[Xl? NX[3bJNIUW6qaXLpeIlwdiCxZjDJUE05KHKnbHXhd4Uh[nliSFXLNlk{KGOnbHzzJIV5eHKnc4PpcochWEuFLXLleIEzNCCLQ{WwJF0hOC5yN{eg{txONg>? NF;UTmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUe3NVQyQSd-MUW3O|E1OTl:L3G+
P19 cells MWfGeY5kfGmxbjDhd5NigQ>? Mk[0TY5pcWKrdHnvckBw\iCLboP1cIlvKHKnY3XweI9zKGurbnHz[UBqdiCSMUmgZ4VtdHNuIFnDOVAhRSByLkKg{txONg>? MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd5MUSxPUc,OTV5N{G0NVk9N2F-
P19 cells Ml7mSpVv[3Srb36gZZN{[Xl? NWrrPYNOUW6qaXLpeIlwdiCxZjDDZZNmcW5ia3nuZZNmKDFiaX6gVFE6KGOnbHzzMEBKSzVyIE2gNU41KM7:TT6= NWq3SZlYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3O|E1OTlpPkG1O|cyPDF7PD;hQi=>
FL5.12-Akt1 cells MkDBRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IF\MOU4yOi2Da4SxJINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOjlizszNMi=> M33X[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NECzOlI3Lz5zNkSwN|YzPjxxYU6=
MiaPaCa-2 cells NWHkOFhXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IF3pZXBiS2FvMjDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlM4KM7:TT6= MnToQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MEO2NlYoRjF4NECzOlI3RC:jPh?=
FL5.12-Akt1 cells NGLyNJNHfW6ldHnvckBie3OjeR?= NG\3VVhC[3Srdnn0fUBi\2GrboP0JGdUUzNiaX6gSmw2NjF{LVHreFEh[2WubIOsJGVEPTBiPTCwMlQ3KM7:TT6= M4HGU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NECzOlI3Lz5zNkSwN|YzPjxxYU6=
MiaPaCa-2 cells MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NEfLfINCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3pZXBiS2FvMjDj[YxteyxiSVO1NEA:KDBwM{eg{txONg>? NFXsZlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxN|c5OCd-MU[0NVM4QDB:L3G+
FL5.12-Akt1 cells NXW3U5JxTnWwY4Tpc44h[XO|YYm= MYLBZ5Rqfmm2eTDh[4FqdnO2IFfTT|MheGixc4Doc5J6dGG2aX;uJIlvKE[ONT6xNk1Cc3RzIHPlcIx{NCCHQ{WwJF0hOC52NjFOwG0v NHizNWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxN|c5OCd-MU[0NVM4QDB:L3G+
Sf21 cells M1\kU2Z2dmO2aX;uJIF{e2G7 M1;RNGlvcGmkaYTpc44hd2ZiSlHLN{BmgHC{ZYPz[YQhcW5iU3[yNUBk\WyuczygTWM2OCB;IECuNFA3KM7:TT6= MkLmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyOEiwOVkoRjF5MEi4NFU6RC:jPh?=
U937 cells NEi3dHREgXSxdH;4bYNqfHliYYPzZZk> M{XP[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU6OzdiY3XscJMtKEmFNUCgQUAzKM7:TT6= NX3UNod2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewPFgxPjdpPkG3NFg5ODZ5PD;hQi=>
Sf9 cells NGG3O3hHfW6ldHnvckBie3OjeR?= M4nwfFEhdWmw NVuwSlhnUW6qaXLpeIlwdiCxZjDoeY1idiCIeX6g[ZhxemW|c3XkJIlvKFOoOTDj[YxteyCjZoTldkAyKG2rbjDifUBGVEmVQTDpckBxemW|ZX7j[UBw\iBzIIXtc4wwVCCDVGCsJGlEPTBiPTCwMlAxPSEQvF2u NE[4[Yg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{OxOVg2Oyd-MUezNVU5PTN:L3G+
Sf9 cells M2XCW2Z2dmO2aX;uJIF{e2G7 MY[yNEBucW6| MkHiTY5pcWKrdHnvckBw\iCqdX3hckBHgW5iZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bi\nSncjCyNEBucW6|IHL5JGVNUVODIHnuJJBz\XOnbnPlJI9nKDFidX3vcE9NKEGWUDygTWM2OCB;IECuNFE2KM7:TT6= NX23SFlvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezNVU5PTNpPkG3N|E2QDV|PD;hQi=>
Sf9 cells NUnTfndVTnWwY4Tpc44h[XO|YYm= M37kNlEhdWmw NHz3dlFKdmirYnn0bY9vKG:oIHj1cYFvKE[7bjDlfJBz\XO|ZXSgbY4hW2Z7IHPlcIx{KGGodHXyJFEhdWmwIHL5JGVNUVODIHnuJJBz\XOnbnPlJI9nKDFyIIXtc4wwVCCDVGCsJGlEPTBiPTCwMlA{PiEQvF2u Mn3YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|MUW4OVMoRjF5M{G1PFU{RC:jPh?=
Sf9 cells M{nSOWZ2dmO2aX;uJIF{e2G7 M4HBdVIxKG2rboO= Mm\GTY5pcWKrdHnvckBw\iCqdX3hckBHgW5iZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bi\nSncjCyNEBucW6|IHL5JGVNUVODIHnuJJBz\XOnbnPlJI9nKDFyIIXtc4wwVCCDVGCsJGlEPTBiPTCwMlA5OyEQvF2u MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzNzNUi1N{c,OTd|MUW4OVM9N2F-
Sf9 cells M12wSGZ2dmO2aX;uJIF{e2G7 MXixJI1qdg>? M4fMXGlvcGmkaYTpc44hd2ZiaIXtZY4hTnmwIHX4dJJme3OnZDDpckBU\jliY3XscJMh[W[2ZYKgNUBucW5iYomgSWxKW0FiaX6gdJJme2WwY3Wgc4YhOTByIIXtc4wwVCCDVGCsJGlEPTBiPTCwMlI4KM7:TT6= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzNzNUi1N{c,OTd|MUW4OVM9N2F-
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A549 cells MXvDfZRwfG:6aXPpeJkh[XO|YYm= Mn:0O|IhcA>? NYPVZmRIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBu\XSqb3SsJGdKPTBiPTCwMlAxOjRizszNMi=> NEfidpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES4OFc4PSd-MUi0PFQ4PzV:L3G+
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HT29 cells MoTjR5l1d3SxeHnjbZR6KGG|c3H5 NHfBb5U4OiCq M3X3NmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVOjliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgcYV1cG:mLDDHTVUxKD1iMD6wNVA6KM7:TT6= M4Hse|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NEi0O|c2Lz5zOES4OFc4PTxxYU6=
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MCF7 cells NHvtcXBHfW6ldHnvckBie3OjeR?= M1r4NWlvcGmkaYTpc44hd2ZiUFvBJIlvKGi3bXHuJG1ETjdiY3XscJMh[nliYYLyZZku[mG|ZXSg[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyIE2gNkDPxE1w NIrTS5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[1OlM3QSd-MUi2OVY{Pjl:L3G+
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Sf9 cells M{GwWmZ2dmO2aX;uJIF{e2G7 MYfJcohq[mm2aX;uJI9nKGi3bXHuJHpCWDdyIHX4dJJme3OnZDDpckBU\jliY3XscJMtKEmFNUCgQUAxNjB3MzFOwG0v MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDh{M{e4OEc,OTh6MkO3PFQ9N2F-
insect cells NUThTGVzTnWwY4Tpc44h[XO|YYm= NUiyNJlOUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQbY0yKGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[nliSGTSSkwhUUN3MDC9JFAvODFizszNMi=> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF5OUC3Okc,OTlzN{mwO|Y9N2F-
HT-29 cells MUnBdI9xfG:|aYOgZZN{[Xl? MWmyJIg> MU\JcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEiWLUK5JINmdGy|IHHzd4V{e2WmIHHzJINp[W6pZTDpckBucXSxY3jvcoRzcWGuIITyZY5{dWWvYoLhcoUheG:2ZX70bYFtKGGodHXyJFIhcHK|IHL5JGpEOSC|dHHpcolv\yCkYYPl[EBndHWxcnXzZ4Vv[2ViYYPzZZktKEWGNUCgQUAxNjByMk[g{txONg>? NYj1NGt2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0NlIzODZpPkG5OFIzOjB4PD;hQi=>
insect Sf21 cells MmO1SpVv[3Srb36gZZN{[Xl? NWfPWINZUW6qaXLpeIlwdiCxZjDKRWs{KGW6cILld5Nm\CCrbjDpcpNm[3RiU3[yNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHLpc5RqdnmuYYTl[EB{fWK|dILheIUheGixc4Doc5J6dGG2aX;uMEBKSzVyIE2gNE4xODZizszNMi=> MlvoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2MkeyNFMoRjF7NEK3NlA{RC:jPh?=
Jurkat cells NFrjSFhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFrBT|Mh\XiycnXzd4lv\yCLTEKtd5RqdXWuYYTl[EBpfW2jbjDKeZJs[XRiY3XscJMtKEmFNUCgQUAxNjB5MTFOwG0v NIrDWnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUSyO|IxOyd-MUm0NlczODN:L3G+
Jurkat cells NYrXS2JNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NW[4VFZSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBLSUt|IHX4dJJme3OrbnegbJVu[W5icnXzeIlv\yCMdYLrZZQh[2WubIOsJGlEPTBiPTCwMlMyOSEQvF2u NInt[|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUSyO|IxOyd-MUm0NlczODN:L3G+
HUE cells M4XGcmZ2dmO2aX;uJIF{e2G7 MnniPVAhdWmwcx?= MVPJcohq[mm2aX;uJI9nKF[HR1\SNkBqdiCKVVWgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCYRVfGMYlv\HWlZXSgZZV1d3Cqb4PwbI9zgWyjdHnvckB1emWjdHXkJIZweiB7MDDtbY5{KGKnZn;y[UBXTUeIIHPoZYxt\W6pZTDifUBGVEmVQTygTWM2OCB;IECuNFch|ryPLh?= NXK5SFl7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxO|AyPjNpPkKwNVcxOTZ|PD;hQi=>
Sf9 cells NXzjdFJ6TnWwY4Tpc44h[XO|YYm= MknROlAhdWmwcx?= M4nlRWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiR2PUMYZ2e2WmIF7JT{BmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHHmeIVzKDZyIH3pcpMh[nlicnHkbY9u\XS{aXOgdJJwfGWrbjDrbY5ie2ViYYPzZZktKEmFNUCgQUAzNjNizszNMi=> M3;DZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUiwOVUzLz5{MEW4NFU2OjxxYU6=
Sf21 cells NYnFXWNMTnWwY4Tpc44h[XO|YYm= M3voOlMxKHWP MYjJcohq[mm2aX;uJI9nKGi3bXHuJGNJUzJia3nuZZNmKGW6cILld5Nm\CCrbjDpcpNm[3RiU3[yNUBk\WyuczD1d4lv\yCyaH;zdIhwNUOURVL0bYRmKGG|IIP1ZpN1emG2ZTDheEA{OCC3TTygTWM2OCB;IECuNFI4KM7:TT6= MkC2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|M{S3PVYoRjJzM{O0O|k3RC:jPh?=
Sf21 cells Mli2SpVv[3Srb36gZZN{[Xl? NFmyb2k{OCC3TR?= M{CwZWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSVvLMYFteGijIHX4dJJme3OnZDDpckBqdnOnY4SgV4YzOSClZXzsd{B2e2mwZzDwbI9{eGixLWXsbYdpfC2La3HwdIFDNWGucHjhJIF{KHO3YoP0doF1\SCjdDCzNEB2VSxiSVO1NEA:KDBwMEO5JO69VS5? NFHsZmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzOFc6Pid-MkGzN|Q4QTZ:L3G+
Sf21 cells NX\BdYV3TnWwY4Tpc44h[XO|YYm= NEDYeHk{OCC3TR?= NFjQcHZKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFnLT{1j\XSjIHX4dJJme3OnZDDpckBqdnOnY4SgV4YzOSClZXzsd{B2e2mwZzDwbI9{eGixLWXsbYdpfC2La3HwdIFDNWGucHjhJIF{KHO3YoP0doF1\SCjdDCzNEB2VSxiSVO1NEA:KDBwNEmg{txONg>? NYnFeVN4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzN|Q4QTZpPkKxN|M1Pzl4PD;hQi=>
HeLa cells MVHDfZRwfG:6aXPpeJkh[XO|YYm= NYfMPYJUPDhiaB?= NGfoepFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjByMECwOEDPxE1w Mnj3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|OEixPVEoRjJzM{i4NVkyRC:jPh?=
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HT-29 cells MmD2SpVv[3Srb36gZZN{[Xl? MWOyJIg> NYPyRmJrTW[oZXP0JI9vKG2rdH;jbI9v\HKrYXygcYVu[nKjbnWgdI91\W62aXHsJIlvKGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFIhcHK|IIXzbY5oKEqFLUGgd5RicW6rbnegZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwJF0hOC5yMEKg{txONg>? NYWxUmYzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0Nlg{PzVpPkKxOFI5Ozd3PD;hQi=>
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MCF7 cells NFjs[HFEgXSxdH;4bYNqfHliYYPzZZk> MVK0PEBp NHXHUIREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB3IN88UU4> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR6OE[1OUc,OjF2OEi2OVU9N2F-
HT-29 cells M4HDOGZ2dmO2aX;uJIF{e2G7 MWrJcohq[mm2aX;uJI9nKG2rdH;jbI9v\HKrYXygcYVu[nKjbnWgdI91\W62aXHsJIlvKGi3bXHuJGhVNTJ7IHPlcIx{KHW|aX7nJGpEOSCmeXWgd5RicW6rbnegZpkh\my3b4Lld4NmdmOnIIDsZZRmKHKnYXTldkBie3OjeTygTWM2OCB;IECuNFAzPSEQvF2u MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTVzM{K5N{c,OjF3MUOyPVM9N2F-
SF268 cells MXrDfZRwfG:6aXPpeJkh[XO|YYm= NWD1eJpWPDhiaB?= MmK4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2YzPjhiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODR2IN88UU4> Ml\JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3MUOyPVQoRjJzNUGzNlk1RC:jPh?=
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H460 cells MV\DfZRwfG:6aXPpeJkh[XO|YYm= M3XTWVQ5KGh? MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIOFYxKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCzMlYh|ryPLh?= NUK3VXc4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1NVMzQTRpPkKxOVE{Ojl2PD;hQi=>
HT-29 cells M3fBNWN6fG:2b4jpZ4l1gSCjc4PhfS=> NGrwTmU1QCCq NEPoeHpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOy54IN88UU4> M2fhblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUGzNlk1Lz5{MUWxN|I6PDxxYU6=
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SW1116 cells M33zfGZ2dmO2aX;uJIF{e2G7 NEnURm8zPCCq NGnLXY5KdmirYnn0bY9vKG:oIITlcI9u\XKjc3WgbY4hcHWvYX6gV3cyOTF4IHPlcIx{KGGodHXyJFI1KGi{czDifUBVWkGSLWDDVk1GVEmVQTDhd5NigSxiSVO1NEA:KDhwM{Kg{txONg>? NUPONFE5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlI2OjNpPkKxPVYzPTJ|PD;hQi=>
HT-29 cells MkPVRZBweHSxc3nzJIF{e2G7 Mln1NkBp NUDzb|VpUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDIWE0zQSClZXzsd{Bie3Onc4Pl[EBz\WS3Y4Tpc44hd2ZibXn0c4Npd26mcnnhcEBu\W2kcnHu[UBxd3SnboTpZYwh[W[2ZYKgNkBpenNiYomgeZNqdmdiSlOxJJN1[WmwaX7nJIJ6KG[udX;y[ZNk\W6lZTDj[YxtNWKjc3XkJIF{e2G7LDDFSFUxKD1iMD6wNFI3KM7:TT6= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl5M{GwNUc,OjF7N{OxNFE9N2F-
LoVo cells NG[x[|BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NX7JfFNGPDhidH:gO|IhcA>? M{j1O2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTH;Wc{Bk\WyuczDh[pRmeiB2ODD0c{A4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMEGg{txONg>? Mmm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzOEK5NlkoRjJ{MUiyPVI6RC:jPh?=
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MCF7 cells NFXtTIhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NXPMS|JDPDhiaB?= NFTLXYtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOuNFch|ryPLh?= MnTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3MEOzOlQoRjJ{NUCzN|Y1RC:jPh?=
A431 cells NV\3ZXRLS3m2b4TvfIlkcXS7IHHzd4F6 M{LmS|I1KGh? NXTqWIhsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR|MTDj[YxteyCjZoTldkAzPCCqcoOgeZNqdmdiQX7u[ZhqdiCYZV\JWGMweHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkC3JO69VS5? M{TuWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUSxNFUyLz5{MkW0NVA2OTxxYU6=
MCF7 cells MWDDfZRwfG:6aXPpeJkh[XO|YYm= MXWyOEBp M{jsfmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgNlQhcHK|IIXzbY5oKEGwbnX4bY4hXmWISWTDM5Bzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnegZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5zODFOwG0v MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV2MUC1NUc,OjJ3NEGwOVE9N2F-
BJ cells NGHDe29EgXSxdH;4bYNqfHliYYPzZZk> MlLQO|IhcA>? MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCTkBk\WyuczDh[pRmeiB5MjDodpMh[nliQ3HsZ4VqdiCDTTDhd5NigSxiSVO1NEA:KDBwMECyJO69VS5? MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl{MUC4NUc,OjJ7MkGwPFE9N2F-
CEM cells MVTDfZRwfG:6aXPpeJkh[XO|YYm= MVS3NkBp MkTnR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2VOKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDZYxk\WmwIFHNJIF{e2G7LDDJR|UxKD1iMD6wNlMh|ryPLh?= MljmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7MkGwPFEoRjJ{OUKxNFgyRC:jPh?=
MCF7 cells MlrUR5l1d3SxeHnjbZR6KGG|c3H5 MYW3NkBp NGC5elVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBE[WylZXnuJGFOKGG|c3H5MEBKSzVyIE2gNE4xPjRizszNMi=> NX3lZ|M6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NlExQDFpPkKyPVIyODhzPD;hQi=>
HeLa cells MmfNR5l1d3SxeHnjbZR6KGG|c3H5 NH2zWJM4OiCq MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDZYxk\WmwIFHNJIF{e2G7LDDJR|UxKD1iMD6xO|Uh|ryPLh?= NUHRenJvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NlExQDFpPkKyPVIyODhzPD;hQi=>
HepG2 cells M4L3WWZ2dmO2aX;uJIF{e2G7 NFvhdYszPCCq MWjJcohq[mm2aX;uJI9nKHSnbH;t[ZJie2ViaX6gbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IGTSRXAuWEOULVXMTXNCKGG|c3H5MEBKSzVyIE2gOE4yPCEQvF2u M3n4VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEG4NFk3Lz5{M{CxPFA6PjxxYU6=
SW1116 cells M3vrT2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NFrVO441QCCq MnHVRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVV{GxNVYh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBu\XSqb3SsJGlEPTBiPTC0Mlk2KM7:TT6= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzOEC5Okc,OjNyMUiwPVY9N2F-
HepG2 cells MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M4HHd|Q5KGh? NEjDUXNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQhdWW2aH;kMEBKSzVyIE2gOk44OyEQvF2u NETadm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxPFA6Pid-MkOwNVgxQTZ:L3G+
BGC823 cells M1zmPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M4SxdFQ5KGh? NHfPfJBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLHR|gzOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKG2ndHjv[EwhUUN3MDC9JFYvQDNizszNMi=> MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzOEC5Okc,OjNyMUiwPVY9N2F-
HeLa cells MoPqRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M2PQUVQ5KGh? MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDt[ZRpd2RuIFnDOVAhRSB7LkGyJO69VS5? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzOEC5Okc,OjNyMUiwPVY9N2F-
HCT116 cells NF\kOGRHfW6ldHnvckBie3OjeR?= NEfYepRKdmirYnn0bY9vKG:oIGTOTWsudWWmaXH0[YQhXEOIND;i[ZRiNWOjc3XpckB1emGwc3PybZB1cW:wIHnuJIh2dWGwIFjDWFEyPiClZXzsd{BjgSCkZYThMYxi[3SjbXHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwJF0hOC5yM{mg{txONg>? NFzWSY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{KzNlA3OCd-MkOyN|IxPjB:L3G+
HepG2 cells M{\KfGZ2dmO2aX;uJIF{e2G7 NEnRV2s1QCCq MkfmTY5pcWKrdHnvckBw\iC2ZXzvcYVz[XOnIHnuJIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDUVmFRNVCFUj3FUGlUSSxiSVO1NEA:KDhwMzFOwG0v M{frfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Mke5PFY1Lz5{M{K3PVg3PDxxYU6=
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KE-97 cells MWDDfZRwfG:6aXPpeJkh[XO|YYm= NH7zeVQ4OiCq M1PVPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtGNTl5IHPlcIx{KGGodHXyJFczKGi{czDifUBE\WyuVHn0doUuT2yxIHz1cYlv\XOlZX70JINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOC5zMzFOwG0v Mlz1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MkiyPFMoRjJ2M{K4Nlg{RC:jPh?=
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HuH7 cells NGXNdnVEgXSxdH;4bYNqfHliYYPzZZk> MkHrO|IhcA>? M1vlWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh2UDdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTy[U1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjJ|IN88UU4> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN{OEK4N{c,OjR|MkiyPFM9N2F-
BGC823 cells Mn;TR5l1d3SxeHnjbZR6KGG|c3H5 MlX3O|IhcA>? NX:w[VJYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSkeFOEKzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1emVvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6zPEDPxE1w NVn5UWdCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNlgzQDNpPkK0N|I5Ojh|PD;hQi=>
MCF7 cells MnrTR5l1d3SxeHnjbZR6KGG|c3H5 MX[3NkBp M13G[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTy[U1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjV{IN88UU4> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN{OEK4N{c,OjR|MkiyPFM9N2F-
NIH/3T3 cells MVnDfZRwfG:6aXPpeJkh[XO|YYm= MV65OkBp M3nBWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJG5KUC9|VEOgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDBwMjFOwG0v M2LjR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{[xOVIyLz5{NEO2NVUzOTxxYU6=
A2780 cells MoG0R5l1d3SxeHnjbZR6KGG|c3H5 MXO5OkBp M1zBUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPzhyIHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAxNjJizszNMi=> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4MUWyNUc,OjR|NkG1NlE9N2F-
HT-29 cells NIf6emZEgXSxdH;4bYNqfHliYYPzZZk> M{fvXFk3KGh? MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNE4zKM7:TT6= NI\SR4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO2NVUzOSd-MkSzOlE2OjF:L3G+
8505C cells MVnDfZRwfG:6aXPpeJkh[XO|YYm= MXu5OkBp NU[4TVZPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hQDVyNVOgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDBwMjFOwG0v MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4MUWyNUc,OjR|NkG1NlE9N2F-
518A2 cells MWXDfZRwfG:6aXPpeJkh[XO|YYm= MXq5OkBp MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjC1NVhCOiClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNE4zKM7:TT6= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4MUWyNUc,OjR|NkG1NlE9N2F-
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A549 cells MoXVR5l1d3SxeHnjbZR6KGG|c3H5 NXnsOJN{QTZiaB?= NILYZ4NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAxNjZizszNMi=> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4MUWyNUc,OjR|NkG1NlE9N2F-
V79 MZ cells M1jlfGZ2dmO2aX;uJIF{e2G7 MkO1TY5pcWKrdHnvckBw\iCqdX3hckBidGSxc4Tldo9v\SC|eX70bIF{\SCneIDy[ZN{\WRiaX6gWlc6KE2cIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[Wymb4P0[ZJwdmVic4nueIhme2m|LDDJR|UxKD1iMD6wNVEh|ryPLh?= M{jRcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEKyOVE6Lz5{NESyNlUyQTxxYU6=
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HeLa cells MmCwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MVSyOEB1dyB2ODDo NYmwRVdZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEK0JJRwKDR6IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IEKuO|Ih|ryPLh?= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd7MkixNUc,OjR5OUK4NVE9N2F-
A549 cells MojYRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M2S5cFI1KHSxIES4JIg> MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhOjRidH:gOFghcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOy5yNTFOwG0v NX\zOopsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3PVI5OTFpPkK0O|kzQDFzPD;hQi=>
HepG2 cells NVrvW5dSS3m2b4TvfIlkcXS7IHHzd4F6 MoXsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMtKEWFNUCgQUAzKM7:TT6= MonpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|MU[zNVcoRjJ3M{G2N|E4RC:jPh?=
Raji cells Mn23R5l1d3SxeHnjbZR6KGG|c3H5 MoPWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVoFrcSClZXzsd{whTUN3MDC9JFIh|ryPLh?= NWC2WnZWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNVY{OTdpPkK1N|E3OzF5PD;hQi=>
BJ cells NGrMZVFEgXSxdH;4bYNqfHliYYPzZZk> NEHSfmZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDUiClZXzsd{whTUN3MDC9JFIh|ryPLh?= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTNzNkOxO{c,OjV|MU[zNVc9N2F-
HEK293 cells NHHtSWJEgXSxdH;4bYNqfHliYYPzZZk> NFLFcYNEgXSxdH;4bYNqfHliYXfhbY5{fCCKRVuyPVMh[2WubIOsJGVEPTBiPTCyJO69VS5? NXOyToIxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNVY{OTdpPkK1N|E3OzF5PD;hQi=>
A549 cells MVfDfZRwfG:6aXPpeJkh[XO|YYm= M3LJfVQ5KGh? M1zXRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODJizszNMi=> MmnBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MkW5N|QoRjJ3OEK1PVM1RC:jPh?=
HeLa cells NGTabIdEgXSxdH;4bYNqfHliYYPzZZk> MmfjOFghcA>? NWHoOnQxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMkWg{txONg>? NWDqOnNrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NlU6OzRpPkK1PFI2QTN2PD;hQi=>
PC3 cells MoC3R5l1d3SxeHnjbZR6KGG|c3H5 M1HQOFQ5KGh? NXKwZo1xS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB|MTFOwG0v M3Twd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK1PVM1Lz5{NUiyOVk{PDxxYU6=
MGC-803 cells NWPISnVYTnWwY4Tpc44h[XO|YYm= NEi2bVgzPCCq NWHnVI86UW6qaXLpeIlwdiCxZjD0[YxwdWW{YYPlJIlvKGi3bXHuJG1ISy16MEOgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KFSUQWCtVGNTNUWOSWPBJIF{e2G7LDDJR|UxKD1iOD65O{DPxE1w NVXyNW01RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5NFA3PTZpPkK2PVAxPjV4PD;hQi=>
Sf9 insect cells Mnj5SpVv[3Srb36gZZN{[Xl? NEHUSYYyOCCvaX7z M4jzVGlvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDHV3QhfGGpZ3XkJJJm[2:vYnnuZY51KG[3bHytcIVv\3SqIHj1cYFvKEOKS{Gg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IGPmPUBqdnOnY4SgZ4VtdHNiYX\0[ZIhOTBibXnud{BjgSCudX3pcoV{[2WwdDDBSHAuT2yxIHHzd4F6NCCLQ{WwJF0hOC5yMEGyJO69VS5? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB6OUKxNUc,OjdyOEmyNVE9N2F-
Sf21 cells MYrGeY5kfGmxbjDhd5NigQ>? MXS2NEBucW6| MWPJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEqDS{Kg[ZhxemW|c3XkJIlvKFOoMkGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKFWuaXfoeE1ESUeDR1HJSXRFU0W\WWTWT2QheGixc4Doc5J6dGG2aX;uJJBz\S2rbnP1ZoF1\WRiYnXmc5JmKHO3YoP0doF1\SCjZHTpeIlwdiCjbnSgcYVie3W{ZXSgZYZ1\XJiNkCgcYlveyCkeTDMRW5ETSCmZYTlZ5Rqd25ibXX0bI9lNCCLQ{WwJF0hOC5yMEKg{txONg>? M{n4R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUO3N|U6Lz5{N{GzO|M2QTxxYU6=
Neuro2a cells NWraNXF4S3m2b4TvfIlkcXS7IHHzd4F6 NUCwdlV[PzJiaB?= M3jUZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJG5mfXKxMnGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMEGxN{DPxE1w M4q1blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUWyOFI4Lz5{OEG1NlQzPzxxYU6=
MDA-MB-231 cells M4nMTmZ2dmO2aX;uJIF{e2G7 M1PVUVE3KGh? M4PENWlvcGmkaYTpc44hd2ZicnX0bY5w[myjc4TvcYEheHKxdHXpckBxcG:|cHjvdplt[XSrb36gbY4hcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiBzNjDodpMh[nliSH;lZ4h{fCB|M{O0NkB{fGGrbnnu[{Bj[XOnZDDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTBiPTCwMlA3PiEQvF2u NWHXOplyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0N|E{PDJpPkK4OFMyOzR{PD;hQi=>
Sf9 insect cells MWHGeY5kfGmxbjDhd5NigQ>? MV6yNEBucW6| MlfJTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCQLYTldo1qdmGubImgS3NVNXSjZ3fl[EBGT0[UIFy4OVhTN1R5OUDNM2M4QTeVIITybZBt\SCvdYThcpQh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlvKFOoOTDpcpNm[3RiY3XscJMheHKnaX7jeYJifGWmIH\vdkAzOCCvaX7zJIZwdGyxd3XkJIJ6KGGmZHn0bY9vKG:oIGuzN3BeNUGWUDDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCoaXz0[ZIu[mmwZHnu[{Bu\XSqb3SsJGlEPTBiPTCwMlAxODJ7IN88UU4> NXjKVY1kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0PFIyPTFpPkK4OFgzOTVzPD;hQi=>
HEK293 cells M1TlZmN6fG:2b4jpZ4l1gSCjc4PhfS=> MlPRO|IhcA>? M1fifmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyJGdtdyCudX3pcoV{[2WwdDDhd5NigSxiQ1O1NEA:KDBwMECzOVQh|ryPLh?= M1fUSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkK0O|AyLz5{OE[yOFcxOTxxYU6=
BT549 cells MmnyR5l1d3SxeHnjbZR6KGG|c3H5 MV:yOEBp M4HhSWN6fG:2b4jpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLUOVQ6KGOnbHzzJIlv[3WkYYTl[EBnd3JiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNFgh|ryPLh?= MmqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MEW0N|IoRjJ6N{C1OFMzRC:jPh?=
MDA-MB-468 cells MmLRR5l1d3SxeHnjbZR6KGG|c3H5 NWHzSpB6OjRiaB?= NGiwfnNEgXSxdH;4bYMh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNE[4JINmdGy|IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMUWg{txONg>? NH3qcWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEewOVQ{Oid-Mki3NFU1OzJ:L3G+
MDA-MB-231 cells MkD2R5l1d3SxeHnjbZR6KGG|c3H5 NFfoNpMzPCCq M4DNfGN6fG:2b4jpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5{NDFOwG0v MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDdyNUSzNkc,Ojh5MEW0N|I9N2F-
Vero cells MmjaR5l1d3SxeHnjbZR6KGG|c3H5 M1Lz[|Ih\GG7cx?= M1LvVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFIh\GG7czDifUBk\WyuLYTpeIVzNWeubzDseY1qdmW|Y3XueEBie3OjeTygWGM2OCB;IECuNFAzPCEQvF2u M2n3[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{[zOlQ2Lz5{OEe2N|Y1PTxxYU6=
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KB-3-1 cells M{TW[mFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NGDDOXI2KGSjeYO= M{\STmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS1KtN{0yKGOnbHzzJIFnfGW{IEWg[IF6eyCkeTDXV3QuOSCjc4PhfUwhUUN3MDC9JFAvOiEQvF2u M4DJdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUW2PVE2Lz5{OEm1OlkyPTxxYU6=
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Sf9 insect cells M{Lke2Z2dmO2aX;uJIF{e2G7 NXjvUWl3PjBibXnudy=> MojoTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCNRGKg[ZhxemW|c3XkJIlvKFOoOTDpcpNm[3RiY3XscJMhfXOrbnegWYxq\2i2LVPBS2FISUmHVFTLSXl[XF[NRDDhd{B{fWK|dILheIUh[W[2ZYKgOlAhdWmwczDifUBNSU6FRTDt[ZRpd2RuIFnDOVAhRSByLkCwNlEh|ryPLh?= MnywQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NEm4N|YoRjJ7NUS5PFM3RC:jPh?=
insect cells MYPGeY5kfGmxbjDhd5NigQ>? NEXYdpAyOCCvaX7z MoCzTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCVcnOg[ZhxemW|c3XkJIlvKGmwc3XjeEBk\WyuczD1d4lv\yCXbHnnbJQuWG:ueTDHRXRcTUG\KEG6NVoyMV2wIHHzJJN2[nO2cnH0[UBi\nSncjCxNEBucW6|IHL5JGxCVkOHIH3leIhw\CxiSVO1NEA:KDBwMEC1JO69VS5? NYP6R5Z4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
insect cells NXHCSYxYTnWwY4Tpc44h[XO|YYm= NHu5XWIyPSCvaX7z Mk\sTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCFRFuxM2N6[2yrbjDCJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgeZNqdmdiVXzp[4h1NUOIRlvOTXZVWFKWUGDQV3FIUy2jbXnk[UBieyC|dXLzeJJifGViYX\0[ZIhOTVibXnud{BjgSCOQV7DSUBu\XSqb3SsJGlEPTBiPTCwMlAzPSEQvF2u MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2OUizOkc,Ojl3NEm4N|Y9N2F-
insect cells MoLoSpVv[3Srb36gZZN{[Xl? NV;NVZlwOTVibXnudy=> M1rpbGlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgbJVu[W5iQ1TLNU9EgWOuaX6gRkBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJJV{cW6pIGXsbYdpfC2FRl\LUmlXXFCUVGDQVHNST0tvYX3p[IUh[XNic4Xid5Rz[XSnIHHmeIVzKDF3IH3pcpMh[nliTFHOR2UhdWW2aH;kMEBKSzVyIE2gNE4xOjVizszNMi=> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2OUizOkc,Ojl3NEm4N|Y9N2F-
Sf9 insect cells NGq0N5dHfW6ldHnvckBie3OjeR?= NH;TcY8yPSCvaX7z NIjqXXhKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIF\seFEh\XiycnXzd4VlKGmwIGPmPUBqdnOnY4SgZ4VtdHNidYPpcochXWyrZ3j0MXRMKHCncITp[IUh[XNic4Xid5Rz[XSnIHHmeIVzKDF3IH3pcpMh[nliTFHOR2UhdWW2aH;kMEBKSzVyIE2gNE4xOzVizszNMi=> NU\G[Yp1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
Sf21 insect cells NU\LTYJ2TnWwY4Tpc44h[XO|YYm= NWnjV21OOTVibXnudy=> NWXq[nJ2UW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDBeZJwemFvQTDlfJBz\XO|ZXSgbY4hW2Z{MTDpcpNm[3RiY3XscJMhfXOrbnegWYxq\2i2LWLSVnNNVEViYYOgd5Vje3S{YYTlJIFnfGW{IEG1JI1qdnNiYomgUGFPS0VibXX0bI9lNCCLQ{WwJF0hOC5yM{mg{txONg>? M4fzblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS5PFM3Lz5{OUW0PVg{PjxxYU6=
insect cells MYXGeY5kfGmxbjDhd5NigQ>? MkjFOlAhdWmwcx?= NXPrclJ7UW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDBT3QyKGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMhfXOrbnegR3JGSnSrZHWgZZMhe3Wkc4TyZZRmKGGodHXyJFYxKG2rboOgZpkhVEGQQ1WgcYV1cG:mLDDJR|UxKD1iMD6wOVYh|ryPLh?= MkC3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NEm4N|YoRjJ7NUS5PFM3RC:jPh?=
Sf9 insect cells NHPO[4JHfW6ldHnvckBie3OjeR?= M2X3fVYxKG2rboO= M4\6e2lvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgbJVu[W5iRlHLJIV5eHKnc4Pl[EBqdiCVZkmgbY5{\WO2IHPlcIx{KHW|aX7nJHVtcWeqdD3UT{Bx\XC2aXTlJIF{KHO3YoP0doF1\SCjZoTldkA3OCCvaX7zJIJ6KEyDTlPFJI1mfGixZDygTWM2OCB;IECuNFYzKM7:TT6= NWfxWGQyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
insect cells MnT4SpVv[3Srb36gZZN{[Xl? NYe0R4gyPjBibXnudy=> MnjPTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCDQlyg[ZhxemW|c3XkJIlvKGmwc3XjeEBk\WyuczD1d4lv\yCXbHnnbJQuXEticHXweIll\SCjczDzeYJ{fHKjdHWgZYZ1\XJiNkCgcYlveyCkeTDMRW5ETSCvZYToc4QtKEmFNUCgQUAxNjJ7IN88UU4> NUTQeXMyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5OzZpPkK5OVQ6QDN4PD;hQi=>
insect cells M3PodWZ2dmO2aX;uJIF{e2G7 MVe2NEBucW6| M1rVUWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgbJVu[W5iYz3NSXQh\XiycnXzd4VlKGmwIHnud4VkfCClZXzsd{B2e2mwZzDVcIlocHRvQ1HHRWdCUUWWRFvFXXlVXkuGIHHzJJN2[nO2cnH0[UBi\nSncjC2NEBucW6|IHL5JGxCVkOHIH3leIhw\CxiSVO1NEA:KDBwM{Gg{txONg>? NFrBXnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW0PVg{Pid-Mkm1OFk5OzZ:L3G+
PC3 cells NH:4NVdEgXSxdH;4bYNqfHliYYPzZZk> NUHMeoZiPzJiaB?= MkTnR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCwMlA{QSEQvF2u MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV3OEGxPUc,Ojl3NUixNVk9N2F-
Sf9 cells Mn7CSpVv[3Srb36gZZN{[Xl? M1z0eFQ2KG2rboO= MWLJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKENvdHXycYlv[WxiSHnzMZRi\2enZD;OMZRmem2rbnHsJGdUXC22YXfn[YQhTUeIUjCoOlY5KHSxIEGyNVAhemW|aXT1[ZMqKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBU\jliY3XscJMhfXOrbnegVI9tgS1qR3z1MEBVgXJrIHHzJJN2[nO2cnH0[UBu\WG|dYLl[EBi\nSncjC0OUBucW63dHXzJIJ6KEurbnHz[U1IdG9ibIXtbY5me2OnboSgZZN{[XluIFnDOVAhRSByLkC0O{DPxE1w NEexRmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUmwNlcyQSd-Mkm5NFI4OTl:L3G+
Sf9 cells NHOxfXhHfW6ldHnvckBie3OjeR?= M{XG[lQ2KG2rboO= MmD2TY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCQLYTldo1qdmGuIFfTWE11[WepZXSgTGVTOiBqNke5JJRwKDF{NUWgdoV{cWS3ZYOpJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDT[lkh[2WubIOgeZNqdmdiUH;sfU0pT2y3LDDUfZIqKGG|IIP1ZpN1emG2ZTDt[YF{fXKnZDDh[pRmeiB2NTDtbY52fGW|IHL5JGtqdmG|ZT3HcI8hdHWvaX7ld4NmdnRiYYPzZZktKEmFNUCgQUAxNjB4MEig{txONg>? NHi2UZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUmwNlcyQSd-Mkm5NFI4OTl:L3G+
HT-29 cells NFnBWlNHfW6ldHnvckBie3OjeR?= M4WyclMhcA>? NXnIRVZXUW6qaXLpeIlwdiCxZjDtbZRw[2ixbnTybYFtKG2nbXLyZY5mKHCxdHXueIlidCCrbjDoeY1idiCKVD2yPUBk\WyuczDh[pRmeiB|IHjyd{BjgSCMQz2xJJN1[WmwaX7nJIJie2WmIH\seY9z\XOlZX7j[UBie3OjeTygTWM2OCB;IECuNFIh|ryPLh?= NGrkW3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC1O|E2PSd-M{CwOVcyPTV:L3G+
Sf9 cells MVHGeY5kfGmxbjDhd5NigQ>? MmPOTY5pcWKrdHnvckBw\iCQLYTldo1qdmGuIF\MRWcufGGpZ3XkJIh2dWGwIH\1cIwudGWwZ4ToJGNFUzF{IDixJJRwKDF2OUCgdoV{cWS3ZYOpM24ufGW{bXnuZYwhUGm|LYTh[4dm\CCFeXPLJEgyKHSxIEW4NEBz\XOrZIXld{kh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iQWTQMYRmeGWwZHXueEBWVGmpaIStOGUuSlBzIDjUbJI{Py:WaIK0Okkhe3Wkc4TyZZRmKHCncITp[IUheGixc4Doc5J6dGG2aX;uJJBzNCCLQ{WwJF0hOC5yNUOg{txONg>? NYjKdGtYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOlc{PThpPkOwNFY4OzV6PD;hQi=>
Sf9 cells NFnDSHZHfW6ldHnvckBie3OjeR?= NEHiSo9KdmirYnn0bY9vKG:oIF6teIVzdWmwYXygSmxCTy22YXfn[YQhcHWvYX6g[pVtdC2uZX7neIghS0SNMUKgLFEhfG9iMUS5NEBz\XOrZIXld{kwVi22ZYLtbY5idCCKaYOteIFo\2WmIFP5Z2shMDFidH:gOVgxKHKnc3nkeYV{MSCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDBWHAu\GWyZX7k[Y51KFWOaXfoeE01TS2EUEGgLHRpejN5L2TodlQ3MSC|dXLzeJJifGVicHXweIll\SCyaH;zdIhwenmuYYTpc44heHJuIFnDOVAhRSByLkC1N{DPxE1w MlzlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNkezOVgoRjNyME[3N|U5RC:jPh?=
Sf9 cells M4jjW2Z2dmO2aX;uJIF{e2G7 M2nIfmlvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDGUGFINXSjZ3fl[EBpfW2jbjDmeYxtNWynbnf0bEBETEtzMzCoNUB1dyBzNUGyJJJme2mmdXXzLU9PNXSncn3pcoFtKEircz30ZYdo\WRiQ4njT{ApOSC2bzC1PFAhemW|aXT1[ZMqKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIFHUVE1l\XCnbnTlcpQhXUyrZ3j0MVRGNUKSMTCoWIhzOzdxVHjyOFYqKHO3YoP0doF1\SCyZYD0bYRmKHCqb4PwbI9zgWyjdHnvckBxeixiSVO1NEA:KDBwMEW3JO69VS5? M3ryUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyME[3N|U5Lz5|MEC2O|M2QDxxYU6=
Sf9 cells NXq4XGtnTnWwY4Tpc44h[XO|YYm= NVvoS3VEUW6qaXLpeIlwdiCxZjDOMZRmem2rbnHsJGZNSUdvdHHn[4VlKGi3bXHuJIZ2dGxvbHXu[5RpKEOGS{GzJEgyKHSxIEG1NVIhemW|aXT1[ZMqN05vdHXycYlv[WxiSHnzMZRi\2enZDDDfYNMKChzIITvJFU5OCC{ZYPp[JVmeyliZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gRXRRNWSncHXu[IVvfCCXTHnnbJQuPEVvQmCxJEhVcHJ|Nz;UbJI1Pilic4Xid5Rz[XSnIIDldJRq\GVicHjvd5Bpd3K7bHH0bY9vKHC{LDDJR|UxKD1iMD6wOVch|ryPLh?= M{f6SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyME[3N|U5Lz5|MEC2O|M2QDxxYU6=
HCT116 cells M1LvSGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2fWVlQ5KGh? Mn20R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkCzJO69VS5? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODFyNkK5NUc,OzBzME[yPVE9N2F-
Huh7.5 cells M1rvOWN6fG:2b4jpZ4l1gSCjc4PhfS=> M33mXVQ5KGh? MUHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIeYg4NjViY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwNjFOwG0v MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODFyNkK5NUc,OzBzME[yPVE9N2F-
K562 cells NHrUeIVEgXSxdH;4bYNqfHliYYPzZZk> NYLMVmltPDhiaB?= M1jwZ2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwNzFOwG0v M4KxUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUC2NlkyLz5|MEGwOlI6OTxxYU6=
LO2 cells Ml:0R5l1d3SxeHnjbZR6KGG|c3H5 M{GxSlQ5KGh? Mo\XR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG8zKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA6NjVizszNMi=> NGPKWlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEGwOlI6OSd-M{CxNFYzQTF:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-Akt / Akt / PARP /Cleaved PARP; 

PubMed: 24174874     


Western blot analysis for Akt, P-Akt, and cleaved poly(ADP-ribose) polymerase. U87 cells were incubated with 200 nM, 10 nM, and 0.1 nM of staurosporine encapsulated in liposomes and staurosporine for 32 hours.

FAK / RIP; 

PubMed: 15121855     


Western blot (WB) analysis of BT-20 and BT-474 lysates treated with staurosporine (200 nM). Control cells were treated with dimethyl sulfoxide for 18 h.

Ambra1; 

PubMed: 24587252     


SW620 cells treated with various doses of staurosporine for 6 h. Ambra1 levels were measured by Western blot. 

24174874 15121855 24587252
Growth inhibition assay
Cell viability; 

PubMed: 25215174     


Staurosporine reduces cerebellar astrocytes viability. (a) Cerebellar astrocytes were treated with staurosporine 0.1 μM, 0.25 μM, and 0.5 μM for 24 h and the cell viability was measured by MTT transformation. (b) Cerebellar astrocytes were treated with staurosporine 0.5 μM for 6, 12, and 24 h and the cell viability was measured by MTT transformation. Data are presented as mean ± SEM of four independent experiments. ∗ is significantly different from control (P < 0.05).

25215174
Immunofluorescence
Tubulin / Actin; 

PubMed: 25215174     


Morphological changes of astrocytes induced by St are evidenced by the rearrangement of cytoskeletal proteins. Astrocytes were treated with St (0.5 μM) for 12 hours and then were labelled with rhodamine-phalloidin or immunostained for tubulin. Representative images of phase contrast, rhodamine-phalloidin, and tubulin are shown in control and St treated astrocytes. Scale bar represents 50 μm.

Phalloidin / Type II collagen; 

PubMed: 22684244     


Cell were cultured in the absence (a-f) or presence of staurosporine (STSN, 5 × 10-9M) or cytochalasin D (CD, 1 µg/ml) for 1 (upper panel) or 2 (lower panel) days at low density and stained for F-actin (Phalloidin) and type II collagen (Type II). STSN: Staurosporine.

Pyk2; 

PubMed: 19880522     


Pyk2 translocates to the nucleus upon staurosporine addition to ID8 cells. Confocal immunofluorescent analysis of endogenous Pyk2 upon DMSO (control) or 1 μm staurosporine addition for 2 h. The scale bar is 10 μm. 

Annexin; 

PubMed: 15140398     


Induction of apoptosis with staurosporine resulting in activation of the ICE-NIRF probe. Gli36 cells were treated with 50 µM staurosporine for 24 hours (A-C) or with the same percentage of DMSO (0.01%) to which experimental wells were exposed (D-488nm laser, E-633nm laser and F-bright field). To examine the role of caspase-1 in staurosporine-induced apoptosis and probe activation, cells were coincubated in caspase-1 inhibitor (10 µM) and staurosporine (G-I). Staurosporine induces apoptosis, indicated by the positive annexin staining viewed with the 488-nm laser (A), which colocalized with activated probe viewed with the 633-nm laser (B). Coincubation of the caspase-1 inhibitor with staurosporine did not completely block apoptosis, indicated by the relatively higher number of apoptotic cells stained with annexin (G), as those that activated the probe (H). Magnification, x 40; scale bar, 50 µM.

cleaved-caspase 3; 

PubMed: 19840952     


Representative images (×1000 magnification) showing vehicle treated (C) and staurosporine treated (D) cells stained with anti-cleaved caspase 3 antibody and DAPI.

FAK 4.47; 

PubMed: 15121855     


BT-20 or BT-474 cell culture were plated on six-well plates and were treated with staurosporine (200 nM) after 24 h. After 6 h of treatment, cells were immunostained with anti-FAK 4.47 antibody (white arrowheads mark some focal adhesions).

25215174 22684244 19880522 15140398 19840952 15121855
In vivo In the gerbil and rat ischemia models, Staurosporine pretreatment (0.1-10 ng) before ischemia prevents neuronal damage in a dose-dependent manner, suggesting the involvement of PKC in CAl pyramidal cell death after ischemia. [8]

Protocol

Kinase Assay:

[1]

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Enzyme assay and binding assay:

Protein kinase C is assayed in a reaction mixture (0.25 mL) containing 5 μmol of Tris/HCl, pH 7.5, 2.5 μmol of magnesium acetate, 50 μg of histone II S, 20 μg of phosphatidylserine, 0.88 μg of diolein, 125 nmol of CaCl2, 1.25 nmol of [γ-32]ATP (5-10 × 104 cpm/nmol) and 5 μg of partially purified enzyme. The binding of [3H]PDBu to protein kinase C is determined: Reaction mixture (200 μL contained 4 μmo1 of Tris/malate, pH 6.8, 20 μmol of KCl, 30 nmol of CaC12, 20 μg of phosphatidylserine, 5 μg of partially purified protein kinase C, 0.5% (final concentration) of DMSO,10 pmol of [3H]PDBu (l-3 × 104 cpm/pmol) and 10 μL of various amounts of Staurosporine.
Cell Research:

[3]

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  • Cell lines: PC12
  • Concentrations: Dissolved in DMSO, final concentration 1 μM
  • Incubation Time: ~32 hours
  • Method:

    Cells are exposed to Staurosporine for ~32 hours. Cells are fixed in 4% paraformaldehyde and stained with the DNA-binding dye Hoechst 33342. Cells are visualized under epifluorescence illumination, and the percentage of apoptotic cells (cells with condensed and fragmented DNA) is determined.


    (Only for Reference)
Animal Research:

[8]

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  • Animal Models: Male Mongolian gerbils or male Wistar rats subjected to transient ischemia
  • Dosages: ~10 ng
  • Administration: Stereotaxically administered into the bilateral CAl subfield of the hippocampus
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL (8.57 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 466.53
Formula

C28H26N4O3

CAS No. 62996-74-1
Storage powder
in solvent
Synonyms Antibiotic AM-2282, STS
Smiles CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID