research use only

SN 52

Cat.No.P1238

SN52, a cell-permeable peptide containing the p50 NLS, is a selective inhibitor of NF-κB pathway. It selectively and completely blocks the ionizing radiation (IR)-induced nuclear import of p52 and RelB. It also enhances the radiosensitivity of prostate cancer cells.

Amino-acid Sequence

SN 52 Amino-acid Sequence

CAS No. 1071173-56-2

Quality Control

Batch: P123801 Water] 100 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.01%

99.01

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Biological Activity

Description	SN52, a cell-permeable peptide containing the p50 NLS, is a selective inhibitor of NF-κB pathway. It selectively and completely blocks the ionizing radiation (IR)-induced nuclear import of p52 and RelB. It also enhances the radiosensitivity of prostate cancer cells.
Targets/IC₅₀/Ki	NF-κB

References

https://pubmed.ncbi.nlm.nih.gov/18723484/

Product Information

Molecular Formula	C₁₂₈H₂₃₀N₃₈O₂₈
Molecular Weight	2749.44
CAS No.	1071173-56-2
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)