Sivelestat sodium tetrahydrate

For research use only.

Catalog No.S4666 Synonyms: Sivelestat sodium, ONO5046-Na, Sodium sivelestat, EI546 sodium, LY544349 sodium

1 publication

Sivelestat sodium tetrahydrate Chemical Structure

Molecular Weight(MW): 528.51

Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.

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Selleck's Sivelestat sodium tetrahydrate has been cited by 1 publication

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Biological Activity

Description Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.
Targets
neutrophil elastase [1]
In vitro

Sivelestat suppresses both adhesion and transmigration of neutrophils to the endothelium[2].

In vivo Intraoperative administration of sivelestat effectively reduced neutrophil induction and activation in the lung and improved oxygenation after cardiopulmonary bypass in a piglet model[1].By inhibiting neutrophil elastase, sivelestat has a direct action to the accumulated and activated leucocytes, offering efficient protection against the production of oxygen radicals and cytokines[3].

Protocol

Cell Research:

[2]

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  • Cell lines: human umbilical vein endothelial cell (HUVEC)
  • Concentrations: 1, 10, and 50 μg/mL
  • Incubation Time: 1 h
  • Method:

    HUVEC are grown to confluence on fibronectin (25 μg/mL) coated Falcon cell culture inserts. Neutrophils stimulated by PAF (0.1 mM) are added to the HUVEC monolayers (upper chamber). The upper chamber is exposed to 2 mL of HUMEDIA and rehydrated at 37 ℃ for 1 h in the absence or the presence (50 μg/mL) of sivelestat. Subsequently, the upper chamber is removed and the fluid in the lower chamber is collected.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Neonatal piglets
  • Dosages: 2 mg/kg/h
  • Administration: Intraoperative administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (189.21 mM)
Ethanol 100 mg/mL (189.21 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 528.51
Formula

C20H21N2O7S.4H2O.Na

CAS No. 201677-61-4
Storage powder
in solvent
Synonyms Sivelestat sodium, ONO5046-Na, Sodium sivelestat, EI546 sodium, LY544349 sodium
Smiles O.O.O.O.[Na+].CC(C)(C)C(=O)OC1=CC=C(C=C1)[S](=O)(=O)NC2=CC=CC=C2C(=O)NCC([O-])=O

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID