For research use only.

Catalog No.S7585

2 publications

SB-334867 Chemical Structure

CAS No. 792173-99-0

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.

Selleck's SB-334867 has been cited by 2 publications

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Biological Activity

Description SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
OX1 receptor [1]
In vitro

In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response. [1]

In vivo In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. [2] SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats. [3] SB-334867 also inhibits the development of morphine analgesic tolerance in rats. [4]


Animal Research:[2]
- Collapse
  • Animal Models: Male and female Sprague–Dawley rats
  • Dosages: 30 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 63 mg/mL (197.29 mM)
Ethanol 3 mg/mL warmed (9.39 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 319.32


CAS No. 792173-99-0
Storage powder
in solvent
Synonyms N/A
Smiles CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4

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Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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% DMSO % % Tween 80 % ddH2O

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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OX Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID