SR-4370

Catalog No.S2132

For research use only.

SR-4370 is a potent and selective inhibitor of class I HDACs with IC50 of 0.13 µM, 0.58 µM, 0.006 µM, 2.3 µM, 3.7 µM for HDAC 1, HDAC 2, HDAC 3, HDAC 8, HDAC 6, respectively.SR-4370 suppresses AR signaling and in vivo prostate tumor growth.

SR-4370 Chemical Structure

CAS No. 1816294-67-3

Purity & Quality Control

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Biological Activity

Description SR-4370 is a potent and selective inhibitor of class I HDACs with IC50 of 0.13 µM, 0.58 µM, 0.006 µM, 2.3 µM, 3.7 µM for HDAC 1, HDAC 2, HDAC 3, HDAC 8, HDAC 6, respectively.SR-4370 suppresses AR signaling and in vivo prostate tumor growth.
Targets
HDAC3 [1]
(Cell-free assay)
HDAC1 [1]
(Cell-free assay)
HDAC2 [1]
(Cell-free assay)
HDAC8 [1]
(Cell-free assay)
HDAC6 [1]
(Cell-free assay)
0.006 μM 0.13 μM 0.58 μM 2.3 μM 3.7 μM
In vitro

SR-4370 can induce cell death of the aggressive breast cancer MDAMB-231 cells with IC50 of 12.6 μM.[1].

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 304.33
Formula

C17H18F2N2O

 

CAS No. 1816294-67-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCNNC(=O)C1=CC=C(C=C1)C2=C(C(=CC=C2)F)F

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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