Sunitinib (SU11248) malate

For research use only.

Licensed by Pfizer Catalog No.S1042

119 publications

Sunitinib (SU11248) malate Chemical Structure

CAS No. 341031-54-7

Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.

Selleck's Sunitinib (SU11248) malate has been cited by 119 publications

Purity & Quality Control

Choose Selective PDGFR Inhibitors

Biological Activity

Description Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.
Targets
IRE1α [7]
()
Kit [1]
(Cell-free assay)
FLT3 [1]
(Cell-free assay)
PDGFRβ [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
2 nM 80 nM
In vitro

Sunitinib also potently inhibits Kit and FLT-3. [1] Sunitinib is a potent ATP-competitive inhibitor of VEGFR2 (Flk1) and PDGFRβ with Ki of 9 nM and 8 nM, respectively, displaying >10-fold higher selectivity for VEGFR2 and PDGFR than FGFR-1, EGFR, Cdk2, Met, IGFR-1, Abl, and src. In serum-starved NIH-3T3 cells expressing VEGFR2 or PDGFRβ, Sunitinib inhibits VEGF-dependent VEGFR2 phosphorylation and PDGF-dependent PDGFRβ phosphorylation with IC50 of 10 nM and 10 nM, respectively. Sunitinib inhibits VEGF-induced proliferation of serum-starved HUVECs with IC50 of 40 nM, and inhibits PDGF-induced proliferation of NIH-3T3 cells overexpressing PDGFRβ or PDGFRα with IC50 of 39 nM and 69 nM, respectively. [2] Sunitinib inhibits phosphorylation of wild-type FLT3, FLT3-ITD, and FLT3-Asp835 with IC50 of 250 nM, 50 nM, and 30 nM, respectively. Sunitinib inhibits the proliferation of MV4;11 and OC1-AML5 cells with IC50 of 8 nM and 14 nM, respectively, and induces apoptosis in a dose-dependent manner. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
3T3 MkHQT4lv[XOnIFHzd4F6 MXHJcohq[mm2aX;uJI9nKFCGR1[tbY5lfWOnZDDCdoRWKGmwY3;ydI9z[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEC3JO69VQ>? M1XLclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkS2NFE6Lz5zMk[0OlAyQTxxYU6=
3T3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHUWpBLUW6qaXLpeIlwdiCxZjDQcIF1\WyndD3k[ZJqfmWmIHfyc5d1cCCoYXP0c5IhcW6mdXPl[EA{XDNiY3XscEBxem:uaX\ldoF1cW:wIIfpeIghUUN3MDDv[kAxNjBzIN88US=> NHLOXHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[0OlAyQSd-MUK2OFYxOTl:L3G+
3T3 MoD5SpVv[3Srb36gRZN{[Xl? NHf3WGZKdmirYnn0bY9vKG:oIG\hd4N2dGG{IHXu[I91cGWuaXHsJIdzd3e2aDDmZYN1d3JicnXj[ZB1d3Jid3n0bEBKSzVyIH;mJFAvODVizszN NFPvWYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[0OlAyQSd-MUK2OFYxOTl:L3G+
3T3 NF3O[XVMcW6jc3WgRZN{[Xl? M12zNVIxKG2rbh?= NFTTNFJFVVOR MlXwR4VtdHWuYYKgbY5pcWKrdHnvckBw\iCYRVfGJIlv\HWlZXSgbJVu[W5iS1TSJJBpd3OyaH;yfYxifGmxbjD3bZRpKEmFNUCgc4YhOC5yMkKg{txO NV\Lc5lVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[xOlIxODhpPkG2NVYzODB6PD;hQi=>
NIH3T3 M2rLRmtqdmG|ZTDBd5NigQ>? M{faTVIxKG2rbh?= NVyzcGw5TE2VTx?= NXOxT|hjcW6qaXLpeEBpfW2jbjDLSHIhc2mwYYPlJIV5eHKnc4Pl[EB4cXSqIFnDOVAhd2ZiMD6wNVgh|ryP NH71bWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkG2NlAxQCd-MU[xOlIxODh:L3G+
A549 MXvGeY5kfGmxbjDBd5NigQ>? MnXSSG1UVw>? NWW3eHRiUW6qaXLpeIlwdiCxZjDjMW1mfCCmZYDlcoRmdnRiSFfGMYlv\HWlZXSgbJVu[W5iQUW0PUBk\WyuIH3p[5JifGmxbjD3bZRpKEmFNUCgc4YhOiEQvF2= NH7zNm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOESzOFE1PSd-MUi0N|QyPDV:L3G+
DU145 NV\lfWJDTnWwY4Tpc44hSXO|YYm= NVjSUI9xTE2VTx?= NYftZ3V[UW6qaXLpeIlwdiCxZjDjMW1mfCCmZYDlcoRmdnRiSFfGMYlv\HWlZXSgbJVu[W5iRGWxOFUh[2WubDDzZ4F1fGW{aX7nJJdqfGhiSVO1NEBw\iBzMDFOwG0> MnjiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2M{SxOFUoRjF6NEO0NVQ2RC:jPh?=
KB3-1 NU\DeFJpS3m2b4TvfIlkKEG|c3H5 NGTGOXk4OiCq Mli0SG1UVw>? MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQMYdxNW6nZ3H0bZZmKEuELUOtNUBk\WyuczD3bZRpKEmFNUCgc4YhOi5|IN88US=> MoH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|OUezNlIoRjF7M{m3N|IzRC:jPh?=
KBV1 NWWxVnpsS3m2b4TvfIlkKEG|c3H5 M4Hre|czKGh? NFXuUHJFVVOR NHTofXJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRNWeueXPvdJJwfGWrbj3lfJBz\XO|aX7nJGtDXjFiY3XscJMhf2m2aDDJR|UxKG:oIESuNUDPxE1? MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7N{OyNkc,OTl|OUezNlI9N2F-
A375 MkXOR5l1d3SxeHnjJGF{e2G7 MofCO|IhcA>? NHnQNXJFVVOR NITlfY5KSzVyPUWuOEDPxE1? NEDGXpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[1OFQxQCd-MUm2OVQ1ODh:L3G+
RS4-11 MWTGeY5kfGmxbjDBd5NigQ>? MW[yJIg> MkXzTY5pcWKrdHnvckBw\iCITGSzJIF2fG:yaH;zdIhwenmuYYTpc44hf2m2aDDJR|UxKG:oIECuNFA6QSEQvF2= Mn3jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4NUS0NFgoRjF7NkW0OFA5RC:jPh?=
RS4-11 M{jyemZ2dmO2aX;uJGF{e2G7 MlTYNkBp NIPzXYdKdmirYnn0bY9vKG:oIF\MWFMhUVSGIH31eIFvfCCjdYTvdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjB|NDFOwG0> MmH0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4NUS0NFgoRjF7NkW0OFA5RC:jPh?=
Sf9 NXPOUIxDU2mwYYPlJGF{e2G7 Mn76N|AhdWmw NEHTZmVKdmirYnn0bY9vKG:oIFfTWE11[WepZXSgWmVITlJiZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAxNjF6NTFOwG0> MlywQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6NUSwOVEoRjF7OEW0NFUyRC:jPh?=
Ba/F3 M{HCeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTQcZVLPzJiaB?= NWO2cINZUUN3ME2xMlIh|ryP Mn7BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMUewNFQoRjJyMUG3NFA1RC:jPh?=
BaPTC2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVyye5k1PzJiaB?= MVHJR|UxRTBwMkKg{txO M3TJ[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUG3NFA1Lz5{MEGxO|AxPDxxYU6=
Sf9 NF7vd25HfW6ldHnvckBCe3OjeR?= NF;BNnYyKGh? MmjoSG1UVw>? NVz3NZJVUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDIbZMufGGpZ3XkJHJGXCCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFEvOyEQvF2= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODFzN{CwOEc,OjBzMUewNFQ9N2F-
H4 MXvDfZRwfG:6aXOgRZN{[Xl? NHfjU2UyOCEQvF2= M{TSe3RwgGmlaYT5JIlvKGi3bXHuJGg1KGOnbHzz M2f5bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPFA3Lz5{MEO1NFgxPjxxYU6=
SF-539 MYTLbY5ie2ViQYPzZZk> M4f0O|M{OyEQvF2= MkfPOlAhdWmw NXmyUXNSTE2VTx?= M2HOcGlvcGmkaYTpc44hd2ZiUFTHSnJj\XSjIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNVIvOiEQvF2= MkC0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2MEO3NFAoRjJyNECzO|AxRC:jPh?=
U251 M{\xcWtqdmG|ZTDBd5NigQ>? MonDN|M{KM7:TR?= MXy2NEBucW5? M3XrW2ROW09? MVPJcohq[mm2aX;uJI9nKF[HR1\SNkBxcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDF6Lkmg{txO Moe3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2MEO3NFAoRjJyNECzO|AxRC:jPh?=
A431 M1f2TGtqdmG|ZTDBd5NigQ>? NYPEfWZRUW6qaXLpeIlwdiCxZjDQSGdHWmKndHGg[ZhxemW|c3XkJJdqfGhiSVO1NEBw\iBzMj6yJO69VQ>? M33BfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUW4NFczLz5{MEW1PFA4OjxxYU6=
A431 M3G2cmtqdmG|ZTDBd5NigQ>? MkjnTY5pcWKrdHnvckBw\iCYRVfGVlIh\XiycnXzd4VlKHerdHigTWM2OCCxZjCxPE46KM7:TR?= NHrjdWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEW1PFA4Oid-MkC1OVgxPzJ:L3G+
HepG2 NHzDWVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDiO|IhcA>? NFz0cHZKSzVyPUOuPFEh|ryP MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODV5MEWyOkc,OjB3N{C1NlY9N2F-
Kasumi-1 NXHMSphLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3GyZlczKGh? M{jHTGlEPTB;MD6wNVYh|ryP Ml\HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3N{C1NlYoRjJyNUewOVI3RC:jPh?=
RS4-11 MlXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHL[|Y4OiCq NG\QXJZKSzVyPUGg{txO NFLiSIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEW3NFUzPid-MkC1O|A2OjZ:L3G+
THP1 MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTQTXNZPzJiaB?= NVfqc5JLUUN3ME2wMlUh|ryP MlPEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3N{C1NlYoRjJyNUewOVI3RC:jPh?=
Kasumi-1 NEHBXpdHfW6ldHnvckBCe3OjeR?= NYPlSG1QUW6qaXLpeIlwdiCxZjDjMWtqfCCjdYTvdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjBzNTFOwG0> M{nwW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEOzNFM6Lz5{MEizN|A{QTxxYU6=
A549 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{GyUlE3KGh? NGTie2VCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzz NYeweGg4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ|PD;hQi=>
HL60 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVixOkBp MX7BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTE[wJINmdGy| Mm\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUC0OlMoRjJzNEWwOFY{RC:jPh?=
HUVEC NWj4cWFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTjO5dOOTZiaB?= M4XSbGlvcGmkaYTpc44hd2ZiVlXHSk1qdmS3Y3XkJINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiMj63OUDPxE1? MoX0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUC0OlMoRjJzNEWwOFY{RC:jPh?=
HUVEC NYXEeYlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWraVYNGOTZiaB?= M2j3NGlvcGmkaYTpc44hd2ZiYl\HSk1qdmS3Y3XkJINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiND6wOEDPxE1? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR3MES2N{c,OjF2NUC0OlM9N2F-
IM9 MnLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPOOpRIOTZiaB?= NUnZUYw3SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTW06KGOnbHzz NXHEdpRPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ|PD;hQi=>
K562 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX6xOkBp NEK3XmZCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzz MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR3MES2N{c,OjF2NUC0OlM9N2F-
MDA-MB-231 NGOwRYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\Qc45FOTZiaB?= MU\BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{ M{HNRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEWwOFY{Lz5{MUS1NFQ3OzxxYU6=
H460 MmHLR5l1d3SxeHnjJGF{e2G7 M4HtUlczKGh? NYPlNI04UUN3ME2yMlch|ryP M3L0cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkKxPFgxLz5{MU[yNVg5ODxxYU6=
SMMC7721 NGTKfWtEgXSxdH;4bYMhSXO|YYm= MmnvO|IhcA>? NIrZWpJKSzVyPU[uOFch|ryP MmXuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4MkG4PFAoRjJzNkKxPFgxRC:jPh?=
WI38 MVXDfZRwfG:6aXOgRZN{[Xl? M{\wbFczKGh? M3PzSGlEPTB;OD61OkDPxE1? NYLPXGlQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2NlE5QDBpPkKxOlIyQDhyPD;hQi=>
HEK293 MoniT4lv[XOnIFHzd4F6 NVm3PI9YOTByIH7N NYXwe4NtOSCq MmO2[I9meyCwb4SgbY5pcWKrdDDWSWdHNWmwZIXj[YQh[XW2b4Doc5NxcG:{eXzheIlwdiCxZjD0fZJwe2mwZTCxNVc2KHKnc3nkeYUhd25iVlXHSnIzKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJM> M2L4bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEi1Nlg4Lz5{MUi4OVI5PzxxYU6=
HUVEC MYTGeY5kfGmxbjDBd5NigQ>? MVmxJO69VQ>? NYrkSGxrOjRiaB?= MoOyRY51cWGwZ3nv[4VvcWNiYXP0bZZqfHliYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hXkWJRj3pcoR2[2WmIHPlcIwhdWmpcnH0bY9v M{nJR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[zN|A2Lz5{MUm2N|MxPTxxYU6=
HUVEC MnTySpVv[3Srb36gRZN{[Xl? NXLFSG1vOSEQvF2= M{LhT|EhcA>? MnW2TY5pcWKrdHnvckBw\iCHUlugdIhwe3Cqb4L5cIF1cW:wIHH0JHRpejJyMj;UfZIzODRiaX6gWmVITi2|dHnteYxifGWmIFjVWmVE MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4M{OwOUc,OjF7NkOzNFU9N2F-
HUVEC MYPGeY5kfGmxbjDBd5NigQ>? M2nMWVEh|ryP M{DVcVEhcA>? MnnUTY5pcWKrdHnvckBw\iCnTl;TJJBpd3OyaH;yfYxifGmxbjDheEBU\XJvMUG3NkBqdiCYRVfGMZN1cW23bHH0[YQhUFWYRVO= MoPkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkOzNFUoRjJzOU[zN|A2RC:jPh?=
HUVEC NUPqVYdQU2mwYYPlJGF{e2G7 M4TP[lEh|ryP M{XnWlEhcA>? Mmm3TY5pcWKrdHnvckBw\iCYRVfGVlIheGixc4Doc5J6dGG2aX;uJIF1KHS7cj2xNVc2KGmwIG\FS2Yue3SrbYXsZZRm\CCKVW\FRy=> NWrFVGJ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlM{ODVpPkKxPVY{OzB3PD;hQi=>
HUVEC MoC0SpVv[3Srb36gRZN{[Xl? MnHTNUDPxE1? NUDhdGVOOSCq M{LLdoRw\XNibn;0JIlvcGmkaYSgRWtVKHCqb4PwbI9zgWyjdHnvckBifCCVZYKtOFc{KGmwIG\FS2Yue3SrbYXsZZRm\CCKVW\FRy=> M1nZS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[zN|A2Lz5{MUm2N|MxPTxxYU6=
HL60 MUPDfZRwfG:6aXOgRZN{[Xl? M2XkclUxKM7:TR?= MXy0PEBp MVvEUXNQ M3HBO2lEPTB;MUWuOUDPxE1? MlfiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMUmxPFgoRjJ{MEG5NVg5RC:jPh?=
K562 NWDYelZMS3m2b4TvfIlkKEG|c3H5 MYq1NEDPxE1? NIfCcGk1QCCq MnP6SG1UVw>? NWS1[mRuUUN3ME2yNU46KM7:TR?= M2C2W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEG5NVg5Lz5{MkCxPVE5QDxxYU6=
PC3 MnTSR5l1d3SxeHnjJGF{e2G7 MYK1NEDPxE1? NWj4Z5duPDhiaB?= NVrrVIhYTE2VTx?= MmPSTWM2OD1{NT6xJO69VQ>? NHzONVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCxPVE5QCd-MkKwNVkyQDh:L3G+
SF-539 MlLJT4lv[XOnIFHzd4F6 M13yVlM{OyEQvF2= NIHsTJM3OCCvaX6= MWfJcohq[mm2aX;uJI9nKFCGR1\SZoV1[SC2eYLvd4lv\SCtaX7hd4Uh[WO2aY\peJkhcW5iUFTHSk1DSi2|dHnteYxifGWmIHj1cYFvKFOILUWzPUBk\WyuczD3bZRpKEmFNUCgc4YhOTJwMjFOwG0> NFu2OHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKwOFc1OSd-MkKyNFQ4PDF:L3G+
HAEC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DweVExOCEQvF2= NVe4e|k4PzJiaB?= NYPQVWJ5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIRWVEKGOnbHzzJIV5eHKnc4PpcochXkWJRmKge4l1cCCLQ{WwJI9nKDBwMTFOwG0> MnPxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NES2O|koRjJ{NES0Olc6RC:jPh?=
HT-29 MnWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;GTHlrOTByIN88US=> NEPNSGM4OiCq M1i5NmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOg[ZhxemW|c3nu[{BXTUeIUjD3bZRpKEmFNUCgc4YhOC5|MzFOwG0> NFvkcmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS0OFY4QSd-MkK0OFQ3Pzl:L3G+
MV4-11 NIDJ[WJEgXSxdH;4bYMhSXO|YYm= MojtO|IhcA>? NXnWWWxzUUN3ME2wMlAxOyEQvF2= M2C4UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEWyOVE5Lz5{MkS1NlUyQDxxYU6=
HepG2 MVzDfZRwfG:6aXOgRZN{[Xl? NFK1bYk1QCCq NHT1c3RKSzVyPUGzMlI1KM7:TR?= NX\ycWdQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFM3ODhpPkKyOFg{PjB6PD;hQi=>
PC9 MmfnR5l1d3SxeHnjJGF{e2G7 MX:0PEBp MnKxTWM2OD1zMD65O{DPxE1? NWLPenRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFM3ODhpPkKyOFg{PjB6PD;hQi=>
CAKI-1 M2GwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[wcZhLOTByIN88US=> M17ucFQ5KGh? MmrMSG1UVw>? MkXYS2k2OD1yLk[zJO69VQ>? NXjaOllzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OlA3OjdpPkKyOVYxPjJ5PD;hQi=>
EKVX MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHYc|UyODBizszN MoXoOFghcA>? MX\EUXNQ MX7HTVUxRTdwOTFOwG0> NHWxW2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
MCF7 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7pfmcyODBizszN MXu0PEBp NH2z[W5FVVOR MnLNS2k2OT1{IN88US=> NI\wTlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
MDA-MB-435 M4jhUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[2NVAxKM7:TR?= MnH4OFghcA>? M{PmUGROW09? MV7HTVUzRTJizszN MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
OVCAR3 NVy2TZhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDBbIIyODBizszN NEjlNm01QCCq M2XUPWROW09? Mn7YS2k2Oz1|LkKg{txO M3zxU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NU[wOlI4Lz5{MkW2NFYzPzxxYU6=
SNB19 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWmxNFAh|ryP M{DrVFQ5KGh? NGm5blRFVVOR NIfF[JVIUTV2PUGwJO69VQ>? NG\GZ3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
SW620 MnjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf4OIZROTByIN88US=> MUK0PEBp Ml7TSG1UVw>? NG\Od4NIUTV3PUGuN{DPxE1? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
TK10 M3;TUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVuxNFAh|ryP NH[xfXM1QCCq Ml;MSG1UVw>? MmHUS2k2Pj14LkOg{txO NELwUJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
UACC257 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYCxNFAh|ryP M3zMVlQ5KGh? NVjxNIdkTE2VTx?= MlLjS2k2Pz12IN88US=> NXPlRVlCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OlA3OjdpPkKyOVYxPjJ5PD;hQi=>
HAEC NXv5NVVDS3m2b4TvfIlkKEG|c3H5 MUexNFAh|ryP MVO3NkBp NVWzc4dtTE2VTx?= M3nFTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KF[HR1\SJIV5eHKnc4PpcochUEGHQzD3bZRpKEmFNUCgc4YhOC5zIN88US=> M4j2NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUOxOVQyLz5{M{GzNVU1OTxxYU6=
HT-29 MnvnR5l1d3SxeHnjJGF{e2G7 NXe3N2lbOTByIN88US=> MXi3NkBp NV[3Zo1DTE2VTx?= NFr6SIZEgXSxdH;4bYNqfHliYXfhbY5{fCCYRVfGVkBmgHC{ZYPzbY5oKGi3bXHuJGhVNTJ7IHPlcIx{KHerdHigTWM2OCCxZjCwMlM{KM7:TR?= NUjrcZpkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxN|E2PDFpPkKzNVMyPTRzPD;hQi=>
HCT116 Mle5SpVv[3Srb36gRZN{[Xl? NGnCfmEzPCCq Moi2SG1UVw>? MmrDRY51cW2rZ4LheI9zgSCjY4Tpeol1gSCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygcYloemG2aX;u NG[0S4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G1N|IxOCd-MkOxOVMzODB:L3G+
HUVEC NH3FS3ZHfW6ldHnvckBCe3OjeR?= NEDHXHozKM7:TR?= NUjLT|RVOThiaB?= NYjy[GFTTE2VTx?= M{[0fmFvfGmjbnfpc4dmdmmlIHHjeIl3cXS7IHnuJGhWXkWFczD1coRmeiCqeYDvfIlkKGOxbnTpeIlwdiCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHS3YnWg[o9zdWG2aX;u MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF3M{KwNEc,OjNzNUOyNFA9N2F-
ACHN NEf6eWpEgXSxdH;4bYMhSXO|YYm= MXe2JIQ> MU\JR|UxRTJwNTFOwG0> NWnYT3h5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzOlAyODRpPkKzN|YxOTB2PD;hQi=>
A498 M4n2TmN6fG:2b4jpZ{BCe3OjeR?= MVOxNFAh|ryP MWq3NkBp MUPEUXNQ M2rJPGlEPTB;ND6zJO69VQ>? NY[wTVBLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PFk3OjZpPkKzOFg6PjJ4PD;hQi=>
HUVEC M1vhd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfnN{DPxE1? MWSyOEBp MkH3SG1UVw>? MUDBcpRq[W6paX;n[Y5q[yCjY4Tpeol1gSCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKF[HR1[tbY5lfWOnZDD0eYJmKG[xcn3heIlwdiC5aYToJGVEPTBib3[gNE43PDVizszN MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV6M{mxNUc,OjN3OEO5NVE9N2F-
HUVEC NWnOVllDU2mwYYPlJGF{e2G7 MoL4NlAxKM7:TR?= NGfOZoRFVVOR M1nOUWlvcGmkaYTpc44hd2ZiVlXHSnIzKHCqb4PwbI9zgWyjdHnvckBqdiCpcn;3eIgh\mGldH;yMZN1cW23bHH0[YQhUFWYRVO= Mm[5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3OEO5NVEoRjJ|NUizPVEyRC:jPh?=
HUVEC NHm4W4tMcW6jc3WgRZN{[Xl? NWnYcVlDOjByIN88US=> MoXGSG1UVw>? MYTJcohq[mm2aX;uJI9nKF[HR1\SNUBxcG:|cHjvdplt[XSrb36gbY4h\3Kxd4ToJIZi[3Sxcj3zeIlufWyjdHXkJGhWXkWF MnfJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3OEO5NVEoRjJ|NUizPVEyRC:jPh?=
A549 NEPjb2NEgXSxdH;4bYMhSXO|YYm= NYfoPGprPzJiaB?= NYTYNHBOTE2VTx?= NGjq[3hKSzVyPUKuOFQh|ryP NV\JdnNvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NFI1PDFpPkKzOlAzPDRzPD;hQi=>
HCT116 NIrI[mREgXSxdH;4bYMhSXO|YYm= NXLUNWFyPzJiaB?= NGj2TolFVVOR NUnBb|ZMUUN3ME20MlcyKM7:TR?= NInxUXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNlQ1OSd-MkO2NFI1PDF:L3G+
MCF7 MmHFR5l1d3SxeHnjJGF{e2G7 M1KyflczKGh? NHTmXJdFVVOR MWDJR|UxRTZwMkmg{txO M321[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkCyOFQyLz5{M{[wNlQ1OTxxYU6=
BGC MkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHh[Fg4OiCq NF[0dY9FVVOR NVzy[3RZUUN3ME20Mlc5KM7:TR?= NGHJe|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1OCd-MkO5PVkxPDB:L3G+
BxPC3 NYTWUoI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXlc4o3PzJiaB?= MV;EUXNQ NG\Xd5RKSzVyPUOuOlMh|ryP MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl7OUC0NEc,OjN7OUmwOFA9N2F-
HT-29 NFH5bHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXK3NkBp MV;EUXNQ M1f1eGlEPTB;MT60O{DPxE1? NFztTY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1OCd-MkO5PVkxPDB:L3G+
T24 NX;aZldKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUm3NkBp NHv3VZZFVVOR MWHJR|UxRTJwNESg{txO NYn3SWNSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDBpPkKzPVk6ODRyPD;hQi=>
4T1 MmPzR5l1d3SxeHnjJGF{e2G7 MWm3NkBp MVfEUXNQ NI\LVHdKSzVyPUCuNFE3KM7:TR?= NIrBU3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MCF7 MlK3R5l1d3SxeHnjJGF{e2G7 M3fYN|czKGh? M3Px[2ROW09? MlTiTWM2OD1yLkCyO|Eh|ryP NFnhfZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MCF7 NHTrWotEgXSxdH;4bYMhSXO|YYm= MWG3NkBp MYHEUXNQ M37TZ2lEPTB;MD6wNlk{KM7:TR?= MkD6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
MDA-MB-231 MULDfZRwfG:6aXOgRZN{[Xl? NH3je5k4OiCq NU[4ZnB6TE2VTx?= MVfJR|UxRTBwMEKyN{DPxE1? MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7ME[1Nkc,OjR6OUC2OVI9N2F-
MDA-MB-435 NYPaWXlqS3m2b4TvfIlkKEG|c3H5 MoHwO|IhcA>? M{L5RmROW09? NXiwVZNpUUN3ME2wMlAxQTdizszN NU\JZnBDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PVA3PTJpPkK0PFkxPjV{PD;hQi=>
MDA-MB-468 NY\Nbno1S3m2b4TvfIlkKEG|c3H5 Ml\2O|IhcA>? NIXleoNFVVOR NFrM[mxKSzVyPUCuNFA3OSEQvF2= NFLTW4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
A431 NIPj[JBMcW6jc3WgRZN{[Xl? MVWxNEDPxE1? MmLzNUBp MljxSG1UVw>? NV3TOmxMUW6qaXLpeIlwdiCxZjDFS2ZTKHerdHigTWM2OCCxZjCwMlE4OjFizszN NIW3Zlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
SH-SY5Y NXLjUYN2U2mwYYPlJGF{e2G7 NXG5UpQ{OTBizszN NXTwc45nOSCq M4jpe2ROW09? M3\rO2lvcGmkaYTpc44hd2ZiUFTHSnJj\XSjIIfpeIghUUN3MDDv[kAxNjB6M{Gg{txO NU\6W5BFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PVA3PTJpPkK0PFkxPjV{PD;hQi=>
U251 MlTPT4lv[XOnIFHzd4F6 NHKzbWkyOCEQvF2= M3q3d|EhcA>? MmHYSG1UVw>? MVjJcohq[mm2aX;uJI9nKF[HR1\SNkB4cXSqIFnDOVAhd2ZiMD6wNVg6KM7:TR?= M1LTSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
Bel7402 MoHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXQOVI4OiCq MYHEUXNQ NHnxU5VKSzVyPUKuOlch|ryP MkTzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MES5OlEoRjJ2OUC0PVYyRC:jPh?=
HK2 NWe4c5VxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33vcFczKGh? MYHEUXNQ NVK1WWpiUUN3ME21Mlg2KM7:TR?= M3zIWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
LO2 M3XoXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{C2VVczKGh? M{m1OmROW09? MYLJR|UxRTF7LkmzJO69VQ>? Mn3rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MES5OlEoRjJ2OUC0PVYyRC:jPh?=
MV4-11 NUmwT|lvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofTOFghcA>? NV3Vc4VkTE2VTx?= M3S1XWlEPTB;MD6wNFMh|ryP NXLWUG5pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFQ6PjFpPkK0PVA1QTZzPD;hQi=>
NCI-H3122 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkC3O|IhcA>? MXfEUXNQ NWTIOWk3UUN3ME2wMlg{KM7:TR?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2NUc,OjR7MES5OlE9N2F-
NCI-H460 NWDkXXBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfINI86PzJiaB?= MY\EUXNQ NGPrN4lKSzVyPUSuN|Eh|ryP M3TYbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
NCI-H526 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDMO|IhcA>? NVrQVFZDTE2VTx?= M1jqVGlEPTB;MT6wNUDPxE1? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2NUc,OjR7MES5OlE9N2F-
TT MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXz0XXlPPzJiaB?= MoHISG1UVw>? MlHUTWM2OD1yLkC0JO69VQ>? NXLxcIVpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFQ6PjFpPkK0PVA1QTZzPD;hQi=>
3T3 NIrKS2NCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmjzO|IhcHK| NU\lNnFrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTCzWFMh[2WubIOg[ZhxemW|c3nu[{BpfW2jbjDDV2YyWiCjZoTldkA4OiCqcoOgZpkhS2WubITpeIVzKGG|c3H5MEBC[3Srdnn0fUA:KDBwMEmg{txONg>? NVfORpo2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2PVQ3PDFpPkG4Olk1PjRzPD;hQi=>
MV4-11 NG\U[VBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MlPHO|IhcHK| MnPWRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPVkStNVEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFA1OyEQvF2u NVrDU5YxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OVQyQTlpPkG5O|U1OTl7PD;hQi=>
HEK293 NUj3Vo1NTnWwY4Tpc44h[XO|YYm= MV\CbY5lcW6pIHHm[olvcXS7IITvJGZNXDNiY3H0ZYx6fGmlIHTvcYFqdiCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGK7IHPvcZBmfGm2aY\lJIJqdmSrbnegZZN{[XluIFvkJF0hOC5yMEC0O{DPxE1w MnS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5NUSxPVkoRjF7N{W0NVk6RC:jPh?=
FDC-P1 Mo\pSpVv[3Srb36gZZN{[Xl? NFfvZlY1QCCqcoO= MWPJcohq[mm2aX;uJI9nKGi3bXHuJGZOWyCneIDy[ZN{\WRiaX6g[5Jwf3SqIH\hZ5RweiCmZYDlcoRmdnRibX;1d4UhTkSFLWCxJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiRl3TMY1m\GmjdHXkJINmdGxicILvcIln\XKjdHnvckBqdiCycnXz[Y5k\SCqdX3hckBEW0ZzIHHmeIVzKDR6IHjyd{BjgSC{ZYPhfpVzcW5iZInlJJJm\HWldHnvckBie3OjeTygTWM2OCB;IECuNVU2KM7:TT6= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF3Nk[4PUc,OjBzNU[2PFk9N2F-
primary leukemia cells MXXDfZRwfG:6aXPpeJkh[XO|YYm= Ml32O|IhcHK| NV\jfXF2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4heHKrbXHyfUBt\XWtZX3pZUBk\WyuczDpd49t[XSnZDDmdo9uKGGldYTlJI16\WyxaXSgcIV2c2WvaXGgdIF1cWWwdDDlfJBz\XO|aX7nJGZNXDNvSWTEJI12fGG2aX;uJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDseYNq\mW{YYPlJIF{e2G7LDDJR|UxKD1iMD6wN{DPxE1w NWXTOI96RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlEzODFpPkKyNlIyOjBzPD;hQi=>
primary leukemia cells M{fIUmN6fG:2b4jpZ4l1gSCjc4PhfS=> M4j1RlczKGi{cx?= M2nJVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJBzcW2jcomgcIV2c2WvaXGgZ4VtdHNiaYPvcIF1\WRiZoLvcUBi[3W2ZTDtfYVtd2mmIHzleYtmdWmjIIDheIlmdnRiZYjwdoV{e2mwZzD3bYxlKHS7cHWgSmxVOyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhUUN3MDC9JFAvODNizszNMi=> M2W4fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkKxNlAyLz5{MkKyNVIxOTxxYU6=
primary leukemia cells Mm\PR5l1d3SxeHnjbZR6KGG|c3H5 M1PKXlczKGi{cx?= MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwdolu[XK7IHzleYtmdWmjIHPlcIx{KGm|b3zheIVlKG[{b32gZYN2fGVibYnlcI9q\CCuZYXr[Y1q[SCyYYTp[Y51KGW6cILld5NqdmdiRlzUN{1FQDN3WTDteZRifGmxbjDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nlibIXjbYZmemG|ZTDhd5NigSxiSVO1NEA:KDFwMTFOwG0v M{Gyb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkKxNlAyLz5{MkKyNVIxOTxxYU6=
endothelial precursor cells NFr5eYFHfW6ldHnvckBie3OjeR?= MkX3TY5pcWKrdHnvckBw\iCnbnTveIhmdGmjbDDjc5JlKGG{ZXGg[o9zdWG2aX;uJIlvKGWwZH;0bIVtcWGuIIDy[YN2enOxcjDj[YxteyCkeTDDSFMyKGOxcnSgZZJm[SCmZYTlZ5Rqd25iYnHz[YQheGinbn;0fZBq[yCmcoXnJIRqe2OxdnXyfUBj[XOnZDDhd5NigSxiSVO1NEA:KDBwMEC5OkDPxE1w NVn0eJJ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0NFk3PjZpPkKyOFA6PjZ4PD;hQi=>
endothelial precursor cells MnzHSpVv[3Srb36gZZN{[Xl? MVvJcohq[mm2aX;uJI9nKGOnbHygcYloemG2aX;uJIlvKGWwZH;0bIVtcWGuIIDy[YN2enOxcjDj[YxteyCkeTDPdol{KGOnbHygcYloemG2aX;uJItqfCCkYYPl[EBxcGWwb4T5dIlkKGS{dXeg[Il{[2:4ZYL5JIJie2WmIHHzd4F6NCCLQ{WwJF0hOTNwNjFOwG0v MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjRyOU[2Okc,OjJ2MEm2OlY9N2F-
U251 NUTwW2ZSTnWwY4Tpc44h[XO|YYm= NWr3ZXJYPjBibXnudy=> NV3HclFzUW6qaXLpeIlwdiCxZjDWSWdHWjJiaX6gbJVu[W5iVUK1NUBk\WyuczDwdoV1emWjdHXkJIZweiB4MDDtbY5{KG2nYYP1doVlKGGodHXyJFEhcHJiYomgSWxKW0FuIFnDOVAhRSBzOD65JO69VS5? M3robVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{O5NFkxLz5{MkezPVA6ODxxYU6=
U251 M1rpVGZ2dmO2aX;uJIF{e2G7 M2DxNFYxKG2rboO= MnTrTY5pcWKrdHnvckBw\iCYRVfGMYlv\HWlZXSgWmVITlJ{IIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCXMkWxJINmdGy|IH;2[ZJmgHC{ZYPzbY5oKE[uaz2xJJBz\XS{ZXH0[YQh\m:{IE[wJI1qdnNicILpc5IhfG9iVlXHSkBi\GSrdHnvckBu\WG|dYLl[EBi\nSncjCxNEBucW6|IHL5JJBpd3OyaH;0fZJwe2mwZTDFUGlUSSCleYTvZoxwfCCjbnHsfZNqeyxiSVO1NEA:KDF6Lkmg{txONg>? M2PWNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{e1NFkxLz5{M{O3OVA6ODxxYU6=
U251 NX;XbGZyTnWwY4Tpc44h[XO|YYm= Mlr0OlAhdWmwcx?= M3PrW2lvcGmkaYTpc44hd2ZiVlXHSnIzKGmwIHj1cYFvKFV{NUGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCYRVfGMYlv\HWlZXSgeJlzd3OrbnWgdIhwe3Cqb4L5cIF1cW:wIHnuZ5Vj[XSnZDDmc5IhPjBibXnud{BxemmxcjD0c{BXTUeILXHjeIl3[XSrb36gcYVie3W{ZXSgNVAhdWmwczDifUBGVEmVQTygTWM2OCB;IEG4Mlkh|ryPLh?= M13i[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEO0NVM6Lz5{M{SzOFE{QTxxYU6=
CHO NWru[ZVFTnWwY4Tpc44h[XO|YYm= NXfWdGhkUW6qaXLpeIlwdiCxZjDDZZYyNjJiY4XydoVvfCCvZXHzeZJm\CC3c3nu[{BSWGG2Y3igZZV1d22jdHnjJJBifGhiY3zhcZAhe3m|dHXtJIlvKEOKTzDj[YxteyCneIDy[ZN{cW6pIFPhelEvOixiYnX0ZU0zKGGwZDDhcJBp[S1{L3TlcJRiNTFic4XieY5qfHNuIFnDOVAhRSB|Mz60JO69VS5? NUTocYZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVI2ODNpPkKzPFEzPTB|PD;hQi=>
U251 NVL4WYVmTnWwY4Tpc44h[XO|YYm= NGq2To5KdmirYnn0bY9vKG:oIG\FS2ZTOiCrbjDoeY1idiCXMkWxJINmdGy|IHL5JJBpd3OyaH;0fZJwe2mwZTDFUGlUSSxiSVO1NEA:KDBwMEG4PUDPxE1w NXjEOWtlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA5PjVpPkK0PVAxQDZ3PD;hQi=>
MCF7 NU\ObGxkSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NEf3Zog1QCCqcoO= MkjlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD61JO69VS5? MkLyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyNkSzOFcoRjJ3ME[0N|Q4RC:jPh?=
HepG2 M1jmOmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MXu0PEBpenN? NHfOOVFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxN{43KM7:TT6= NUfPXYhERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwOlQ{PDdpPkK1NFY1OzR5PD;hQi=>
CHO NEjST4VHfW6ldHnvckBie3OjeR?= Mo\YTY5pcWKrdHnvckBw\iC{YYDp[EBl\WyjeXXkJIlvf2G{ZDDy[YN1cW[7aX7nJJBwfGG|c3n1cUBkfXK{ZX70JEhKU3JrIHnuJGNpcW6nc3WgbIFue3SncjDveoFzgSBqQ1jPLUBk\WyuczDzeIFjdGViZYjwdoV{e2mwZzDoSXJIKG2nYYP1doVlKHW|aX7nJGlwdlexcnvzJGJienKjY4XkZUBifXSxbXH0[YQheGG2Y3igZ4xidXBicHzheIZwem1uIFnDOVAhRSB5Lkm0N|I5KM7:TT6= NYDreWZNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPFc4PTNpPkK1NFg4PzV|PD;hQi=>
CHO K1 MXvGeY5kfGmxbjDhd5NigQ>? NWnpUZdbUW6qaXLpeIlwdiCxZjDyZZBq\CCmZXzhfYVlKGmwd3Hy[EBz\WO2aX\5bY5oKHCxdHHzd4l2dSCldYLy[Y51KCiLS4KpJIlvKEOqaX7ld4UhcGGvc4TldkBwfmG{eTCoR2hQMSCNMTDj[YxteyC|dHHicJkh\XiycnXzd4lv\yCqRWLHJI1m[XO3cnXkJJV{cW6pIFnvcndwemu|IGH1ZZR1em9iYYX0c41ifGWmIIDheINpKGOuYX3wJJBt[XSob4LtMEBKSzVyIE2gNVAh|ryPLh?= NHruRnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4O|c2Oyd-MkWwPFc4PTN:L3G+
CHO K1 MmnmSpVv[3Srb36gZZN{[Xl? NUm1TFlOUW6qaXLpeIlwdiCxZjDmZZN1KHOxZHn1cUBkfXK{ZX70JEhKVmFrIHnuJGNpcW6nc3WgTIFue3SncjDPeoFzgSBqQ1jPLUBMOSClZXzsd{B1emGwc3\lZ5Rm\CC5aYToJIh2dWGwIF7helEvPSCvZXHzeZJm\CC3c3nu[{BKd26Zb4Lrd{BSfWG2dILvJIF2fG:vYYTl[EBx[XSlaDDjcIFueCCybHH0[o9zdSxiSVO1NEA:KDF3Lki0PFkh|ryPLh?= M4Pvc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEi3O|U{Lz5{NUC4O|c2OzxxYU6=
HEK293 Ml3tSpVv[3Srb36gZZN{[Xl? NWHXR29ZUW6qaXLpeIlwdiCxZjDmZZN1KHOxZHn1cUBkfXK{ZX70JEhKVmFrIHnuJGhGUzJ7MzDj[YxteyC2cnHud4Zm[3SnZDD3bZRpKGi3bXHuJG5ifjFwNTDt[YF{fXKnZDD1d4lv\yCLb37Xc5JseyCTdXH0eJJwKGG3dH;tZZRm\CCyYYTjbEBkdGGvcDDwcIF1\m:{bTygTWM2OCB;IEO5MlgyODdizszNMi=> MnPhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEe3OVMoRjJ3MEi3O|U{RC:jPh?=
MOLM13 MoPlR5l1d3SxeHnjbZR6KGG|c3H5 NYPk[YVPPDhiaILz NGPzU3NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOV0yPMUOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMEG3O{DPxE1w MmX2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEm4NVAoRjJ3MEi5PFExRC:jPh?=
MV4-11 MonSR5l1d3SxeHnjbZR6KGG|c3H5 Mn;FOFghcHK| MnXrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUXY1NTFzIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB{NEOg{txONg>? NIjEPIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4PVgyOCd-MkWwPFk5OTB:L3G+
HL60 MYXDfZRwfG:6aXPpeJkh[XO|YYm= M3LGb|Q5KGi{cx?= M4Xab2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNPjBiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODN4ODFOwG0v M1[3W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEi5PFExLz5{NUC4PVgyODxxYU6=
THP1 M1vGSGN6fG:2b4jpZ4l1gSCjc4PhfS=> MnXkOFghcHK| NUnTcI1lS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXEiSMTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yNEW3JO69VS5? NGX1b|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4PVgyOCd-MkWwPFk5OTB:L3G+
ACHN NIL6WJVEgXSxdH;4bYNqfHliYYPzZZk> MnexO|IhcHK| NGD1[JJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCS0iQIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzKM7:TT6= NH3jbFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUGyOFEyPCd-MkWxNlQyOTR:L3G+
U251 M1XUbGZ2dmO2aX;uJIF{e2G7 MnKzOlAhdWmw NG\yTndKdmirYnn0bY9vKG:oIG\FS2ZTOiCrbjDoeY1idiCXMkWxJINmdGy|IHPvcZBwfW6mIIDy[ZRz\WG2ZXSg[o9zKDZyIH3pckBj\W[xcnWgWmVITiC|dHnteYxifGmxbjDmc5IhOTBibXnud{BjgSCyaH;zdIhwfHm{b4PpcoUhTUyLU1GgZ5l1d2Kub4SgcYV1cG:mLDDJR|UxKD1iMD6wNVg6KM7:TT6= NFrqb|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4NlUyQSd-MkW4PFI2OTl:L3G+
U251 M{e5WWZ2dmO2aX;uJIF{e2G7 NIDvO4I3OCCvaX6= MY\Jcohq[mm2aX;uJI9nKFCGR1\SMYJmfGFiaX6gbJVu[W5iVUK1NUBk\WyuczDjc41xd3WwZDDwdoV1emWjdHXkJIZweiB4MDDtbY4h[mWob4LlJHBFT0ZvQlKgd5RqdXWuYYTpc44h\m:{IEGwJI1qdnNiYomgdIhwe3Cqb4T5do9{cW6nIFXMTXNCKGO7dH;icI91KG2ndHjv[EwhUUN3MDC9JFAvODh|MTFOwG0v NIPPb5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4NlUyQSd-MkW4PFI2OTl:L3G+
A431 M3XCTWZ2dmO2aX;uJIF{e2G7 NXPteFFuPjBibXnu Mn7XTY5pcWKrdHnvckBw\iCHR1\SJIlvKGi3bXHuJGE1OzFiY3XscJMh[2:vcH;1coQheHKndILlZZRm\CCob4KgOlAhdWmwIHLl[o9z\SCHR1[gd5RqdXWuYYTpc44h\m:{IEGwJI1qdnNiYomgdIhwe3Cqb4T5do9{cW6nIFXMTXNCKGO7dH;icI91KG2ndHjv[EwhUUN3MDC9JFAvOTd{MTFOwG0v MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh6MkWxPUc,OjV6OEK1NVk9N2F-
HT-29 NH\zRmxEgXSxdH;4bYNqfHliYYPzZZk> NITO[lQ1QCCqcoO= NWrNfWxjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gOE44KM7:TT6= NGLiVY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwPVE3PCd-Mk[wNFkyPjR:L3G+
A549 MUDDfZRwfG:6aXPpeJkh[XO|YYm= MYm0PEBpenN? M4TTO2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iNz65N{DPxE1w MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByOUG2OEc,OjZyMEmxOlQ9N2F-
SKOV3 NHHEOXhEgXSxdH;4bYNqfHliYYPzZZk> M3zCS|Q5KGi{cx?= NULIVmlsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gPU4zOSEQvF2u MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByOUG2OEc,OjZyMEmxOlQ9N2F-
PANC1 MUTDfZRwfG:6aXPpeJkh[XO|YYm= MWW0PEBpenN? Mn7RR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGFPSzFiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iMUSuPVQh|ryPLh?= NG\NUYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwPVE3PCd-Mk[wNFkyPjR:L3G+
HepG2 NYXWd4JPS3m2b4TvfIlkcXS7IHHzd4F6 NXTPb3NHPDhiaILz MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSBzNj6wOkDPxE1w Mn30QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEmxOlQoRjJ4MEC5NVY1RC:jPh?=
MCF7 MYHDfZRwfG:6aXPpeJkh[XO|YYm= M37NeFQ5KGi{cx?= MljnR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSB{NT60NUDPxE1w Mn\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEmxOlQoRjJ4MEC5NVY1RC:jPh?=
Bel7402 M2rCTnBpd3SxY4n0c5RwgGmlaYT5JIF{e2G7 NFnQN442KGi{cx?= NIHqXm9RcG:2b3P5eI91d3irY3n0fUBi\2GrboP0JIh2dWGwIFLlcFc1ODJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkheHKnaX7jeYJifGWmIH\vdkA2KGi{czD3bZRpKGOnbHzzJIZwdGyxd3XkJIJ6KFWYQT2xJIlzemGmaXH0bY9vKGG2IEOuNEBuXy:lbTeyJIZweiB{MDDtbY5{KG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBES0t6IHHzd4F6NCCHQ{WwJF0hOTFizszNMi=> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV6NEC4OUc,OjZ3OESwPFU9N2F-
PANC1 M17FTHBpd3SxY4n0c5RwgGmlaYT5JIF{e2G7 NVnE[WhEPSCqcoO= M4Xt[3Bpd3SxY4n0c5RwgGmlaYT5JIFo[Wmwc4SgbJVu[W5iUFHOR|Eh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgdJJmcW6ldXLheIVlKG[xcjC1JIhzeyC5aYToJINmdGy|IH\vcIxwf2WmIHL5JHVXSS1zIHnydoFlcWG2aX;uJIF1KDNwMDDtW{9kdSd{IH\vdkAzOCCvaX7zJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDDR2s5KGG|c3H5MEBGSzVyIE2gNVMh|ryPLh?= M2iySFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUi0NFg2Lz5{NkW4OFA5PTxxYU6=
SVEC4-10 MYTDfZRwfG:6aXPpeJkh[XO|YYm= M1;ve|I1KGi{cx?= NVi0NY46S3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhW1[HQ{StNVAh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IEig{txONg>? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjlzMkGxNUc,OjZ7MUKxNVE9N2F-
HUVEC M1PpUGFvfGmjbnfpc4dmdmmlIHHzd4F6 MmP5NVAhfU1? NU\qcWZiPSCqcoO= NX7pfmtVSW62aXHu[4lw\2WwaXOgZYN1cX[rdImgbY4hcHWvYX6gTHVXTUNiY3XscJMh[XO|ZYPz[YQh[XNiYX7nbY9o\W6nc3nzJJJifGViYYSgNVAhfU1iYX\0[ZIhPSCqcoOgZpkh\W6mb4To[Yxq[WxidIXi[UBnd3KvYYTpc44h[XO|YYmgdoVt[XSrdnWgeI8h[2:wdILvcC=> NYDFfXBKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5NVIyOTFpPkK2PVEzOTFzPD;hQi=>
HT-29 MVnDfZRwfG:6aXPpeJkh[XO|YYm= MmPqR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMT63JO69VS5? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{MEiwNEc,OjZ7MkC4NFA9N2F-
A549 MnrIR5l1d3SxeHnjbZR6KGG|c3H5 M17rN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOT6xJO69VS5? Ml\BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7MkC4NFAoRjJ4OUKwPFAxRC:jPh?=
MDA-MB-435 MkjlR5l1d3SxeHnjbZR6KGG|c3H5 Mne4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUSzOUBk\WyuczDifUBOXFRiYYPzZZktKEmFNUCgQUA6NjNizszNMi=> MoDuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7MkC4NFAoRjJ4OUKwPFAxRC:jPh?=
MV4-11 MWXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MorpO|IhcHK| NIPTTpFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGZNXDNvSWTEJIRmeGWwZHXueEBpfW2jbjDNWlQuOTFiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUCgQUAxNjByMTFOwG0v MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
HL60 M13VTWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlizO|IhcHK| NW[xeVJFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubz;DR2s5KGG|c3H5MEBIUTVyIE2gNE4xODFizszNMi=> MmnzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
BAF3 M2LNRWZ2dmO2aX;uJIF{e2G7 MkP1O|IhcHK| NHfwfVZKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjT2lVKFR4N{DJJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCTjNiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCCycn;sbYZmemG2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwN0OFS{igZZN{[XluIFfJOVAhRSByLkCwNkDPxE1w Ml\FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
MOLM14 M1u5NGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NVPLfVNyPzJiaILz M4f1OWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgSmxVOy2LVFSg[IVx\W6mZX70JIh2dWGwIF3PUG0yPCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFAvODB3IN88UU4> M3vU[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
BAF3 MoLBSpVv[3Srb36gZZN{[Xl? MoTQO|IhcHK| M1[zV2lvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhXjV3OVSvWlY2PEFiZH;1ZoxmKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCwMlAxPiEQvF2u NETGXlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
BAF3 NVvxNIU{TnWwY4Tpc44h[XO|YYm= NHfhTYo4OiCqcoO= Mk\2TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBXPTV7RDDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W|ZTDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5yMEmg{txONg>? NX\xS3RvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|c4ODVpPkK3NFc4PzB3PD;hQi=>
BAF3 M{K5R2Z2dmO2aX;uJIF{e2G7 M{nFdFczKGi{cx?= MnPlTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBXPjV2QTDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W|ZTDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5yMjFOwG0v MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BAF3 NIWwXo9HfW6ldHnvckBie3OjeR?= NXW2dlEzPzJiaILz NU\ncWRKUW6qaXLpeIlwdiCxZjDU[Ywu\nW|ZXSgZ2tKXCCONU[3VEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ|IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNlMh|ryPLh?= NIrtUXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
GISTT1 NFnET|VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NF;VOI44OiCqcoO= MnTHRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDjT2lVKGSncHXu[IVvfCCqdX3hckBIUVOWVEGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwN0OFS{igZZN{[XluIFfJOVAhRSByLkC0NUDPxE1w NIfwVFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
BAF3 M1zHcmZ2dmO2aX;uJIF{e2G7 NHzXZXI4OiCqcoO= NXn3PVBRUW6qaXLpeIlwdiCxZjDU[Ywu\nW|ZXSgZ2tKXCCWNkewTU9XPTV7RDDkc5VjdGVibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFAvODV|IN88UU4> MnjpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
BAF3 MkDySpVv[3Srb36gZZN{[Xl? MojlO|IhcHK| MnH0TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCwMlA4QCEQvF2u MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
GIST882 NYTRTmtuSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M4L0d|czKGi{cx?= M1jMWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgZ2tKXCCmZYDlcoRmdnRiaIXtZY4hT0mVVEi4NkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNVEh|ryPLh?= NXXrOGRQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|c4ODVpPkK3NFc4PzB3PD;hQi=>
BAF3 M{LyXmZ2dmO2aX;uJIF{e2G7 NIDw[FM4OiCqcoO= M4XVNmlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhVjh{MlugcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8wS0ONODDhd5NigSxiR1m1NEA:KDBwNUGg{txONg>? NY\qVXZxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|c4ODVpPkK3NFc4PzB3PD;hQi=>
Rec1 MX;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlfSO|IhcHK| MkLoRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCUZXOxJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD64O{DPxE1w NXPhTFVmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|c4ODVpPkK3NFc4PzB3PD;hQi=>
K562 NIL2VnRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MkX6O|IhcHK| NXexfGhkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMJIRmeGWwZHXueEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubz;DR2s5KGG|c3H5MEBIUTVyIE2gNUDPxE1w NFr1W5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
KU812 NWrB[lFoSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MlixO|IhcHK| NWjvXolDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMJIRmeGWwZHXueEBpfW2jbjDLWVgyOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFEvOSEQvF2u MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BCR-ABL dependent MEG01 NX;USG82SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYTWcnNUPzJiaILz MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKFUj3BRmwh\GWyZX7k[Y51KE2HR{CxJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMT6yJO69VS5? MmHuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
BAF3 MX\GeY5kfGmxbjDhd5NigQ>? M2LHclczKGi{cx?= MV3Jcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJGQ5OT[YIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUCgQUAyNjN6IN88UU4> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
U937 M4LiVWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mn;0O|IhcHK| M4HDc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVUmzO{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IEGuO{DPxE1w MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
GIST48B NFfyPVBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NYTpXGZqPzJiaILz MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeLU2S0PGIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCyMlAyKM7:TT6= M1\UWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
CHO NI\qNJBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NGXLd3o4OiCqcoO= M2T4OGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgR2hQKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubz;DR2s5KGG|c3H5MEBIUTVyIE2gNk4xOyEQvF2u NIP5NYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
CHL M2fSdmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MoO3O|IhcHK| NHXGe3JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGNJVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFIvPDhizszNMi=> NVrEN5RKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|c4ODVpPkK3NFc4PzB3PD;hQi=>
BAF3 NUHGOHo2SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3Sx[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlHGN{Bk\WyuczygS2k2OCB;IEKuO|gh|ryPLh?= Ml\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
MDA-MB-231 NHHTO3FEgXSxdH;4bYNqfHliYYPzZZk> NWLITWZkPDhiaILz NYj2O3ZRS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gO{41KM7:TT6= Mo\RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMkixO|MoRjJ5MUK4NVc{RC:jPh?=
BT549 M1nNeWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3jRflQ5KGi{cx?= NVHybpppS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSlR3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3LkWg{txONg>? NYLpbXloRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNlgyPzNpPkK3NVI5OTd|PD;hQi=>
DU145 NULS[G1SS3m2b4TvfIlkcXS7IHHzd4F6 NY\1eJlkPDhiaILz NVe1WpVNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF4LkSg{txONg>? MnPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMkixO|MoRjJ5MUK4NVc{RC:jPh?=
PC3 MYXDfZRwfG:6aXPpeJkh[XO|YYm= NHP6VlI1QCCqcoO= NGTaelNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE6NjZizszNMi=> NFi5TIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GyPFE4Oyd-MkexNlgyPzN:L3G+
RWPE1 NX3wdlF[S3m2b4TvfIlkcXS7IHHzd4F6 M3;xTVQ5KGi{cx?= Mli4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVndRTTFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI{KM7:TT6= M3ra[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVc{Lz5{N{GyPFE4OzxxYU6=
MCF7 MkP4SpVv[3Srb36gZZN{[Xl? NIXhbZgyKHWP NH\hPIszPCCqcoO= MoLRTY5pcWKrdHnvckBw\iCYRVfGVlIheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJIV5eHKnc4Ppc44hd2ZicHjvd5Bpd3K7bHH0[YQhTVKNMT:yJIF1KDFidV2gbY5kfWKjdHXkJIZweiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz NW\sTYFERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexO|Y6PDRpPkK3NVc3QTR2PD;hQi=>
MCF7 Ml;hSpVv[3Srb36gZZN{[Xl? M3fs[lEhfU1? MmLWNlQhcHK| NWD2S3BqUW6qaXLpeIlwdiCxZjDWSWdHWjJicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGW6cILld5Nqd25ib3[gdIhwe3Cqb4L5cIF1\WRiUnHmNUBifCBzIIXNJIlv[3WkYYTl[EBnd3JiMkSgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> M4DZ[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUe2PVQ1Lz5{N{G3Olk1PDxxYU6=
PA1 M2nrc2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3jtWFQ5KGi{cx?= M{T0WmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBCOSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPy57NzFOwG0v NWnNTXdtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyNVA1OzhpPkK3NlExPDN6PD;hQi=>
LNCAP Mn3jR5l1d3SxeHnjbZR6KGG|c3H5 NYXUeHo6PDhiaILz NGLGSI9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNVkODUDDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUKuOlEh|ryPLh?= NVTGeWpkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyNVA1OzhpPkK3NlExPDN6PD;hQi=>
RWPE1 NUX3XohzS3m2b4TvfIlkcXS7IHHzd4F6 NXfDbJdvPDhiaILz M2jCOmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJYWEVzIHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{MzFOwG0v NUHYT3l{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyNVA1OzhpPkK3NlExPDN6PD;hQi=>
MCF7 MYHDfZRwfG:6aXPpeJkh[XO|YYm= NEjKR2E1QCCqcoO= MULDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOy55NjFOwG0v MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzJzMESzPEc,Ojd{MUC0N|g9N2F-
MDA-MB-231 Ml7vR5l1d3SxeHnjbZR6KGG|c3H5 NFP1SHM1QCCqcoO= NEHUXWZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPy52NDFOwG0v MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR2OEmxOkc,Ojd2NEi5NVY9N2F-
A549 MljqR5l1d3SxeHnjbZR6KGG|c3H5 MX20PEBpenN? MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTRwNDFOwG0v MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR2OEmxOkc,Ojd2NEi5NVY9N2F-
BT549 NWX5O4FPS3m2b4TvfIlkcXS7IHHzd4F6 MmHtOFghcHK| M4G4OWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJVPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUWuOVQh|ryPLh?= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR2OEmxOkc,Ojd2NEi5NVY9N2F-
DU145 MYrDfZRwfG:6aXPpeJkh[XO|YYm= MWK0PEBpenN? NWrCOXY5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOk4{QCEQvF2u MlvWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2NEi5NVYoRjJ5NES4PVE3RC:jPh?=
PC3 MVXDfZRwfG:6aXPpeJkh[XO|YYm= NWfQOXVMPDhiaILz M2rtXGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF7Lk[g{txONg>? NVvsUXd1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke0OFg6OTZpPkK3OFQ5QTF4PD;hQi=>
MCF7 MXLDfZRwfG:6aXPpeJkh[XO|YYm= NH\Tc|k1QCCqcoO= NHXJPHFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkOuPEDPxE1w M3;IOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NES4PVE3Lz5{N{S0PFkyPjxxYU6=
MDA-MB-231 M1jGW2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYO0PEBpenN? M3TkSmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNz60JO69VS5? Mm\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4M{mzOlkoRjJ5NkO5N|Y6RC:jPh?=
HeLa MoTSR5l1d3SxeHnjbZR6KGG|c3H5 NIiwO2g1QCCqcoO= MkC2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNE41KM7:TT6= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ|OUO2PUc,Ojd4M{mzOlk9N2F-
PC3 NVzo[o9TS3m2b4TvfIlkcXS7IHHzd4F6 NInjb5M1QCCqcoO= MojOR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGyMlYh|ryPLh?= NXvVNYVRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2N|k{PjlpPkK3OlM6OzZ7PD;hQi=>
A549 NFTPSIVEgXSxdH;4bYNqfHliYYPzZZk> NVT6WJVKPDhiaILz Mkm3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOE41KM7:TT6= NX7CUZRURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2N|k{PjlpPkK3OlM6OzZ7PD;hQi=>
BT549 MnHTR5l1d3SxeHnjbZR6KGG|c3H5 NXO4fo92PDhiaILz MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCWFU1QSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOU42KM7:TT6= MkPXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4M{mzOlkoRjJ5NkO5N|Y6RC:jPh?=
DU145 MnLNR5l1d3SxeHnjbZR6KGG|c3H5 NVThVnVjPDhiaILz NUDxUmRCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTZwMzFOwG0v MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ|OUO2PUc,Ojd4M{mzOlk9N2F-
RWPE1 M3TidWN6fG:2b4jpZ4l1gSCjc4PhfS=> NWrvbZRnPDhiaILz NWnkSpZ1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWleSRUGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjVwMjFOwG0v MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ|OUO2PUc,Ojd4M{mzOlk9N2F-
L02 MUTDfZRwfG:6aXPpeJkh[XO|YYm= M3HsRlczKGi{cx?= MoS2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUFAzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFQvPjJizszNMi=> NI\VNnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[0N|Y{QSd-Mke2OFM3Ozl:L3G+
HL60 M3fMcmN6fG:2b4jpZ4l1gSCjc4PhfS=> M{DvNFczKGi{cx?= MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFQvQTVizszNMi=> NEToNGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[0N|Y{QSd-Mke2OFM3Ozl:L3G+
U251 M{DYOmZ2dmO2aX;uJIF{e2G7 Ml7YOlAhdWmwcx?= NXXBR21HUW6qaXLpeIlwdiCxZjDWSWdHWi1{IHnuJIh2dWGwIGWyOVEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIG\FS2YhcW6mdXPl[EBxcG:|cHjvdplt[XSrb36gdJJmcW6ldXLheIVlKG[xcjC2NEBucW6|IH\vcIxwf2WmIHL5JHZGT0ZiYXTkbZRqd25ibXXhd5Vz\WRiYX\0[ZIhOTBibXnud{BjgSCHTFnTRUBu\XSqb3SsJGlEPTBiPTCwMlAyQDlizszNMi=> NHvTcFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i5OFU5QSd-Mke4PVQ2QDl:L3G+
SF539 MWTGeY5kfGmxbjDhd5NigQ>? NHPQWnM3OCCvaX7z MVjJcohq[mm2aX;uJI9nKFCGR1\SMYJmfGFiaX6gbJVu[W5iU1[1N|kh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIGDES2YuSkJiaX7keYNm\CCyaH;zdIhwenmuYYTpc44heHKnaX7jeYJifGWmIH\vdkA3OCCvaX7zJIZwdGyxd3XkJIJ6KFCGR1[tRmIh[WSmaYTpc44hdWWjc4Xy[YQh[W[2ZYKgNVAhdWmwczDifUBGVEmVQTDt[ZRpd2RuIFnDOVAhRSByLkC4N|Eh|ryPLh?= NVzkN3NGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4PVQ2QDlpPkK3PFk1PTh7PD;hQi=>
HuH7 NUPUWIR7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVyybmF4PDhiaILz NUnVfmZXT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUHWKNzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOy5yMzFOwG0v NHK3fpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m1OlM1PCd-Mke5OVY{PDR:L3G+
HCT116 NEfqe5RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoXTOFghcHK| M1KyR2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS54MjFOwG0v MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl3NkO0OEc,Ojd7NU[zOFQ9N2F-
SW620 NHLGRVFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmHLOFghcHK| MmnKS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gV3c3OjBiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFYvOjVizszNMi=> MlfiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7NU[zOFQoRjJ5OUW2N|Q1RC:jPh?=
MV4-11 MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NUjVOpVQPzJiaILz MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2YND2xNUBk\WyuczDoZZJjd3KrbnegSmxVOyCLVFSgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSByLkCzPFUh|ryPLh?= Ml3wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlgoRjJ6MEO4N|I5RC:jPh?=
CHO M4SzbGZ2dmO2aX;uJIF{e2G7 M133UGlvcGmkaYTpc44hd2ZiaIXtZY4hTVKJIHX4dJJme3OnZDDpckBEUE9iY3XscJMh[nliUYDheINpKGG|c3H5MEBKSzVyIE2gNE42KM7:TT6= NF65Xo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECzPFMzQCd-MkiwN|g{Ojh:L3G+
HepG2 NGn5dHpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWDwW2JTPDhiaILz NX\Ob3o6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVYvODZizszNMi=> Mlm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyNUe0NlMoRjJ6MEW3OFI{RC:jPh?=
MCF7 NGPHR41CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NYG0XpZsPDhiaILz NVT5U2prSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOU41OSEQvF2u NH64WYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC1O|QzOyd-MkiwOVc1OjN:L3G+
HEK293 NFjq[45HfW6ldHnvckBie3OjeR?= M17OTlIhdWmwcx?= M2qxRWlvcGmkaYTpc44hd2ZiaIXtZY4hV0OWMTDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHWydHHr[UBw\iCDU2CrJIFnfGW{IEKgcYlveyCkeTDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTBiPTC2MlEh|ryPLh?= M2fCVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkOwPVg2Lz5{OEKzNFk5PTxxYU6=
RCC4 NVjmSJEzSW62aXPhcoNmeiCjc4PhfS=> NX3RenJkPDhiaILz NX7w[ppMSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJHJESzRiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHhVXCCjc4PhfUwhUUN3MDC9JFQh|ryPLh?= MlrwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|MkW2NFAoRjJ6M{K1OlAxRC:jPh?=
MDA-MB-231 NUT4UJNMSW62aXPhcoNmeiCjc4PhfS=> M4XOcFQ5KGi{cx?= NI\OZ|hCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB2ODDodpMh[nliWGTUJIF{e2G7LDDJR|UxKD1iNjFOwG0v M2X6c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{K1OlAxLz5{OEOyOVYxODxxYU6=
COLO205 MYfDfZRwfG:6aXPpeJkh[XO|YYm= MXKyOEBpenN? MoPoR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR29NVzJyNTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQCEQvF2u NV3HeJRNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVYxOjRpPkK4O|U3ODJ2PD;hQi=>
K562 M135b2N6fG:2b4jpZ4l1gSCjc4PhfS=> MUGyOEBpenN? NWTWcIFPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTRizszNMi=> MnXsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NU[wNlQoRjJ6N{W2NFI1RC:jPh?=
MDA-MB-231 MUXDfZRwfG:6aXPpeJkh[XO|YYm= NX[2RYh2OjRiaILz MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|MjFOwG0v NY\oWnlNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVYxOjRpPkK4O|U3ODJ2PD;hQi=>
MDA-MB-231 M1fZPWN6fG:2b4jpZ4l1gSCjc4PhfS=> NG\sSnQzPCCqcoO= MoLTR5l1d3SxeHnjbZR6KGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDZwOUig{txONg>? NUezcJI{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OlA{OTNpPkK4O|YxOzF|PD;hQi=>
MCF7 NWnLXWFiTnWwY4Tpc44h[XO|YYm= Ml3YOEB2VQ>? M36xZVI1KGi{cx?= NHHwPGFKdmirYnn0bY9vKG:oIG\FS2ZTOiCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hVUOINzDj[YxteyCjdDC0JJVOKGmwY4XiZZRm\CCob4KgNlQhcHK|IHL5JHdme3Sncn6gZoxwfCCvZYToc4Q> MlWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NEKxNVMoRjJ6OUSyNVE{RC:jPh?=
GISTT1 MlPzR5l1d3SxeHnjbZR6KGG|c3H5 MYC3NkBpenN? M2Szd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdKW1SWMTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZJIdG9iYYPzZZktKEeLNUCgQUAxNjB2IN88UU4> NFL4SXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm5NVQ3PSd-Mki5PVE1PjV:L3G+
GISTT1 MYrDfZRwfG:6aXPpeJkh[XO|YYm= Mn3JO|IhcHK| M4LCfGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdKW1SWMTDj[YxteyCqYYLic5JqdmdiS1nUJHQ3PzCLIH31eIFvfCCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZJIdG9iYYPzZZktKEeLNUCgQUAxNjB7IN88UU4> M3jxWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUmxOFY2Lz5{OEm5NVQ3PTxxYU6=
GIST430 M2TZNGN6fG:2b4jpZ4l1gSCjc4PhfS=> NYi0clJ7PzJiaILz M4LIOmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdKW1R2M{CgZ4VtdHNiaHHyZo9zcW6pIFvJWEBXPjV2QTDteZRidnRiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzT2yxIHHzd4F6NCCJSUWwJF0hOC5yOUig{txONg>? M4jyOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUmxOFY2Lz5{OEm5NVQ3PTxxYU6=
GISTT1 MYnDfZRwfG:6aXPpeJkh[XO|YYm= Ml\sO|IhcHK| NWDPXotZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hT0mVVGSxJINmdGy|IHjhdoJwemmwZzDLTXQhTDhzNlWgcZV1[W62IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmekeubzDhd5NigSxiR1m1NEA:KDVwOEig{txONg>? Ml;JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7OUG0OlUoRjJ6OUmxOFY2RC:jPh?=
HuH7 NILGRZRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MX60PEBpenN? M2jHdmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSIXIO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iND63NFch|ryPLh?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTB3N{C0Nkc,OjlyNUewOFI9N2F-
A498 NWrQbJRDSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3vQNFQ5KGi{cx?= MmXFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNEm4JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5Lkm4NUDPxE1w MlvwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyNUewOFIoRjJ7MEW3NFQzRC:jPh?=
NCI-H727 M{LIUWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NYXZZ|JIPDhiaILz NXL0RY8ySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDd{NzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTBwMUKg{txONg>? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTB3N{C0Nkc,OjlyNUewOFI9N2F-
MV4-11 MWXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mm\BO|IhcHK| NYridJo4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNmdGy2aYTldk1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjBzIN88UU4> MnnYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7M{W3O|IoRjJ7OUO1O|czRC:jPh?=
HuH7 NWOxbWp4SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEi3SEegZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN{4xOyEQvF2u MkPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNUm4NFMoRjNyMEW5PFA{RC:jPh?=
HCT116 MlfwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MoXDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS54MjFOwG0v MnXWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNUm4NFMoRjNyMEW5PFA{RC:jPh?=
SW620 M{TqWGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOZNkKwJINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFYvOjVizszNMi=> NEXQOJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC1PVgxOyd-M{CwOVk5ODN:L3G+
HepG2 M4q0OWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnG4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDifUBOXFRiYYPzZZktKEmFNUCgQUA4Njd6IN88UU4> Mn20QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNUm4NFMoRjNyMEW5PFA{RC:jPh?=
U251 M3L0d2Z2dmO2aX;uJIF{e2G7 Mnq4OlAhdWmwcx?= NGfWcWlKdmirYnn0bY9vKG:oIG\FS2YucW6mdXPl[EBXTUeIUkKgZYN1cX[jdHnvckBqdiCqdX3hckBWOjVzIHPlcIx{KHC{ZYTy[YF1\WRiZn;yJFYxKG2rboOg[o9tdG:5ZXSgZpkhXkWJRjDh[IRqfGmxbjDhcoQhdWWjc4Xy[YQh[W[2ZYKgNVAhdWmwczDifUBGVEmVQTygTWM2OCB;IECuNFE5QSEQvF2u NF\QV3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFg3QSd-M{CwPVg5Pjl:L3G+
SH-SY5Y M4jBe2Z2dmO2aX;uJIF{e2G7 NH63VJc3OCCvaX7z MYnJcohq[mm2aX;uJI9nKFCGR1[tRmIucW6mdXPl[EBRTEeIUnLleIEh[WO2aY\heIlwdiCrbjDoeY1idiCVSD3TXVV[KGOnbHzzJJBz\XS{ZXH0[YQh\m:{IE[wJI1qdnNiZn;scI94\WRiYomgVGRITi2EQjDh[IRqfGmxbjDhcoQhdWWjc4Xy[YQh[W[2ZYKgNVAhdWmwczDifUBGVEmVQTygTWM2OCB;IECuNFg{OSEQvF2u NEHTNpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFg3QSd-M{CwPVg5Pjl:L3G+
A431 NXnMfXR2TnWwY4Tpc44h[XO|YYm= MX62NEBucW6| NUe1NJptUW6qaXLpeIlwdiCxZjDFS2YucW6mdXPl[EBGT0[UIHHjeIl3[XSrb36gbY4hcHWvYX6gRVQ{OSClZXzsd{BxemW2cnXheIVlKG[xcjC2NEBucW6|IH\vcIxwf2WmIHL5JGVITiCjZHTpeIlwdiCjbnSgcYVie3W{ZXSgZYZ1\XJiMUCgcYlveyCkeTDFUGlUSSxiSVO1NEA:KDBwMUeyNUDPxE1w NIHKR5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5PFg3QSd-M{CwPVg5Pjl:L3G+
BA/F3 NYH0O|AyTnWwY4Tpc44h[XO|YYm= NV[1V5dYPzJiaILz MVTJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMEC0JO69VS5? NVSybZBvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3 M2nMXWZ2dmO2aX;uJIF{e2G7 M4\leFczKGi{cx?= NXH3bW44UW6qaXLpeIlwdiCxZjDLbZQh\XixbjCxNUBl\WyndHnvckApPTV5IITvJFU2QCC{ZYPp[JVmeyliYX7kJGQ5OT[KIH31eIFvfCCjbnSgWFY4OElibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGdKPTBiPTCwMlAxPSEQvF2u NGDIcVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3 MYnGeY5kfGmxbjDhd5NigQ>? M2OxOFczKGi{cx?= M3HtV2lvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW|aXT1[ZMqKGGwZDDWOlU1SSCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IECuNFA3KM7:TT6= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3 M2Lt[GZ2dmO2aX;uJIF{e2G7 NFHQSpA4OiCqcoO= MnnCTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiB7IFHZOVAzKHSxIEWwN{BqdnOncoTpc44hdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkCwO{DPxE1w NF3XUmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3 MUnGeY5kfGmxbjDhd5NigQ>? NIXTPGo4OiCqcoO= MX3Jcohq[mm2aX;uJI9nKEurdDDWOVYxTC:YNkW0RUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMEC3JO69VS5? NGS1UY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3 M3zXUGZ2dmO2aX;uJIF{e2G7 MUm3NkBpenN? NUDxcHZbUW6qaXLpeIlwdiCxZjDLbZQh\XixbjC5JGF[PTB{IITvJFUxOyCrboPldpRqd25iYX7kJHY3PTRibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGdKPTBiPTCwMlAyOiEQvF2u M4PQblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
BA/F3 MXjGeY5kfGmxbjDhd5NigQ>? MmTIO|IhcHK| MV7Jcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OlAhfG9iNUe4JJJme2mmdXXzLUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMEK0JO69VS5? M3zTVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
BA/F3 M2r5TWZ2dmO2aX;uJIF{e2G7 NVPjcGR7PzJiaILz NI\6[2JKdmirYnn0bY9vKG:oIFvpeEBXPTZyRDDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VWyCjc4PhfUwhT0l3MDC9JFAvODJ5IN88UU4> M4HBdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
BA/F3 M2fKTGZ2dmO2aX;uJIF{e2G7 MXu3NkBpenN? MWPJcohq[mm2aX;uJI9nKFSHTD3meZNm\CCSRFfGVoFteGijIDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEeLNUCgQUAxNjB|IN88UU4> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3 M3PnfWZ2dmO2aX;uJIF{e2G7 NGXYW3U4OiCqcoO= MXrJcohq[mm2aX;uJI9nKEuGUjCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCN0Z|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDndo94fGhiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwJF0hOC5yM{Og{txONg>? MljKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3 MVrGeY5kfGmxbjDhd5NigQ>? Mn:3O|IhcHK| MkPMTY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiUFTHSnJj\XSjIDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEeLNUCgQUAxNjFzNDFOwG0v NELiOYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3 M3HtVWZ2dmO2aX;uJIF{e2G7 M4LaV|czKGi{cx?= NU\KXohKUW6qaXLpeIlwdiCxZjDLbZQh\XixbjCxNUBl\WyndHnvckApPTV5IITvJFU2QCC{ZYPp[JVmeyliYX7kJGQ5OjCDIH31eIFvfCCjbnSgSFgzOEFibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGdKPTBiPTCwMlIyPCEQvF2u NF7DSZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3 NIOyWm9HfW6ldHnvckBie3OjeR?= NUjxTVJtPzJiaILz M1K0cWlvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW|aXT1[ZMqKGGwZDDOPFIzUyCvdYThcpQh[W6mIGm4NlNFKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD6yO|Eh|ryPLh?= M3;y[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
BA/F3 MoflSpVv[3Srb36gZZN{[Xl? MVq3NkBpenN? M3fkTGlvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW|aXT1[ZMqKGGwZDDEPFE3UCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IECuN|k5KM7:TT6= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3 M3\D[WZ2dmO2aX;uJIF{e2G7 NIL4S4U4OiCqcoO= M1;zc2lvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW|aXT1[ZMqKGGwZDDBPFI6WCCvdYThcpQh[W6mIGm4NlNFKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD60N{DPxE1w MojHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3 NX;6S5huTnWwY4Tpc44h[XO|YYm= NHzoVXY4OiCqcoO= MmrDTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiB7IFHZOVAzKHSxIEWwN{BqdnOncoTpc44h[W6mIFS4NVYhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkW4OEDPxE1w NXrle|J3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3 MVXGeY5kfGmxbjDhd5NigQ>? M{\wUFczKGi{cx?= Mmr3TY5pcWKrdHnvckBw\iCSRFfGVoFteGijIG[1OlFFN0R6NELWJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCN0Z|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDndo94fGhiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwJF0hOC54M{Gg{txONg>? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3 MnfISpVv[3Srb36gZZN{[Xl? M1LkfVczKGi{cx?= M2nsOGlvcGmkaYTpc44hd2ZiS3n0JGQ5OT[YIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCpcn;3eIghcW6ldXLheIVlKG[xcjC3NkBpenNiYomgUXRUKGG|c3H5MEBIUTVyIE2gNE43OzhizszNMi=> MnXOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3 NVK2VYpETnWwY4Tpc44h[XO|YYm= NVzuPVh4PzJiaILz MXvJcohq[mm2aX;uJI9nKEurdDDWOVYxTC:GOEG2TEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwNkm2JO69VS5? M17nbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
BA/F3 M4TOcGZ2dmO2aX;uJIF{e2G7 NUHZSHp2PzJiaILz NI\sXG1KdmirYnn0bY9vKG:oIFvpeEBmgG:wIEGxJIRmdGW2aX;uJEg2PTdidH:gOVU5KHKnc3nkeYV{MSCjbnSgXVgzO0RibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGdKPTBiPTCwMlc5OiEQvF2u NIPqW489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3 NF\aXXJEgXSxdH;4bYNqfHliYYPzZZk> M1TFS|czKGi{cx?= MoGxR5l1d3SxeHnjbZR6KGmwIH3veZNmKHCjcnXueIFtKEKDL1[zJINmdGy|IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDRwN{i5JO69VS5? Mn:5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
Sf21 MmTGSpVv[3Srb36gZZN{[Xl? NX3nfZEyPjBibXnudy=> MlL4TY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCQLYTldo1qdmGuIFjpd|YufGGpZ3XkJGtFWiBqN{mwJJRwKGWwZDDy[ZNq\HWnczmg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIGPmNlEhcW6|ZXP0JINmdGy|IHHmeIVzKDZyIH3pcpMh[nliRVzJV2EtKEmFNUCgQUAxNjByNEeg{txONg>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ2MUCxNEc,OzB{NEGwNVA9N2F-
EoL-1-cell MojFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrCTWM2OD1zLk[0JJBO MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
MV-4-11 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv2[olKSzVyPUK3NkBxVQ>? NYjDRYhkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NOS-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\GTWM2OD1zNT6zJI5O MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
CGTH-W-1 M4XVNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGWwTHNKSzVyPUOwMlk1KG6P MoK5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
MONO-MAC-6 NHjTcHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTUO3VzUUN3ME2zN{45KG6P NWKyfHpORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
ALL-PO NWDOfphlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTd7Lki5JI5O M3qyeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NKM-1 MkHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;QTWM2OD17OD61NkBvVQ>? NUP6cG85RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
KM12 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M16yXGlEPTB;M{WwMlE1KG6P Mmq2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
TE-15 M4q0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTVyNz62NUBvVQ>? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
697 M3LW[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXzTWM2OD14MUSuNlUhdk1? NYXpOHNqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
MOLT-16 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHGTWM2OD14M{GuN|Ihdk1? NIC2PGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
GB-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHXTWM2OD15MUCuNlMhdk1? NETuc289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
TE-12 NYG2NGtkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLMUo9KSzVyPUiwOE42PSCwTR?= NXL2UWZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
ES6 MlrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDJWXNKSzVyPUm4NU4xPiCwTR?= MkjvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
LC-2-ad M2XYSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPqdW9bUUN3ME2xMlEyPDB5IN88US=> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
BL-70 NWTob5ZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHocXJlUUN3ME2xMlEyQDR4IN88US=> NEPQWoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
ETK-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PGZ2lEPTB;MT6yPFU5KM7:TR?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
A4-Fuk NIr3VXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvUbnhKSzVyPUGuN|QyPDFizszN NFXDZZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
OCI-AML2 M2XXfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3n6VmlEPTB;MT6zOlg2OSEQvF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
SIG-M5 Mn;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\RUJRkUUN3ME2xMlM4ODB7IN88US=> NYG4dmRHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-SNU-16 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTFwNE[0PFYh|ryP NFzsOXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
PSN1 M2L2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq5WZdKSzVyPUGuOVA3PzZizszN MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
SR NVnHPVhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLXc5BKSzVyPUGuOVQ2PzJizszN M4PzeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
A3-KAW NVzBS4l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnWTFF7UUN3ME2xMlYzPTR4IN88US=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
KS-1 NH:0cHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTFwNkmyOFch|ryP NETENmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
CTV-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVO2UlZ6UUN3ME2xMlczPzVzIN88US=> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
LB1047-RCC NYixVGx5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XtTWlEPTB;MT64NVYzPCEQvF2= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
EMG-01 Mlq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTFwOEO1OlMh|ryP MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
TE-11 MnrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\xTWM2OD1zLkizPVg2KM7:TR?= Mnq2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
CMK M2P0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLUZYtKSzVyPUGuPVU2OTdizszN M1nBSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NB1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTFwOU[xNVch|ryP NWi1epFVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
HAL-01 M3;jdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTJwMEW5OFYh|ryP NVP0WpgzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
DEL MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonMTWM2OD1{LkC4OFgzKM7:TR?= NEiyVZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
RL95-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETI[oJKSzVyPUKuNVEyOzdizszN NH3CZo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
KARPAS-299 NYjZW25HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnqyTWM2OD1{LkGxN|E{KM7:TR?= NULYVIZ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
EW-16 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zt[GlEPTB;Mj6xN|UxQCEQvF2= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
RS4-11 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlX5TWM2OD1{LkG3PVI1KM7:TR?= NIXoW3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
BB30-HNC Mo\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7DTWM2OD1{LkKyN|c2KM7:TR?= M1PrZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
DOHH-2 M3vITGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ztOmlEPTB;Mj6zN|Q{OSEQvF2= M2\EOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
RPMI-8402 M2XEcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TSTGlEPTB;Mj6zN|YyQCEQvF2= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
BV-173 M3;6PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\kWllFUUN3ME2yMlM{PjZizszN NGLsW4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
TE-10 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzQTWM2OD1{LkO0N|g1KM7:TR?= NWqyPYtrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
TE-8 NIC3N4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4S5SWlEPTB;Mj6zO|A{QCEQvF2= M{DxZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
K052 MnPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XTOGlEPTB;Mj60NFIxOiEQvF2= M33w[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
KARPAS-45 NF\NdWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvUNoxKSzVyPUKuOFk1PDZizszN NWfpOoNpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
SK-NEP-1 NHnncWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzpephZUUN3ME2yMlYxOjN5IN88US=> NUTYUVRTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
KGN Mn3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\QTWM2OD1{Lk[wN|M6KM7:TR?= M3LOTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
ML-2 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTsVFRKSzVyPUKuOlM2OTJizszN MlLTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
LAMA-84 Ml7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLVTWM2OD1{Lk[5OVQ2KM7:TR?= NYLpVoNVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
LXF-289 NXrjZmx2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL1ToZKSzVyPUKuO|I6QDlizszN M{HJd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
A101D MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PSNGlEPTB;Mj63PFMxPCEQvF2= NX;HcYt{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
KY821 MnTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTJwN{m3OVgh|ryP NIHJV4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
ES4 NHn5U3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTJwOEC2Nlgh|ryP M3m0NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SCC-3 MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\QTGlEPTB;Mj64Nlg6OSEQvF2= M1fMWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NALM-6 Mme2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33yNWlEPTB;Mj65NFQ4OyEQvF2= NWfmdW55RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
BL-41 MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;JcotnUUN3ME2yMlkyOjJ{IN88US=> NHj2dXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
OPM-2 MkPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7ob4dPUUN3ME2zMlA2QTV2IN88US=> Mo[zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
SF126 M3u2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fSXGlEPTB;Mz6wOlE6QCEQvF2= NXXsdmQ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
BE-13 NXGxPFFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVu1TphYUUN3ME2zMlI{OTFzIN88US=> MoTnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
SF268 M{n0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LrVmlEPTB;Mz6zNlg3QSEQvF2= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
MOLT-4 Moe0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTNwM{m4N|gh|ryP NIHMS409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
PF-382 MnvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrTPFd6UUN3ME2zMlQ1PTdizszN NUCzTXE2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
HEL NH3td41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX4cmtGUUN3ME2zMlQ5ODB3IN88US=> M1f6NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
RPMI-6666 M3\wOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rCdmlEPTB;Mz61OFE4OSEQvF2= NXq1fY1[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
QIMR-WIL M2r6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInWTWtKSzVyPUOuOlM{QTFizszN NXLxUm9sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
ATN-1 NV\jOIpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmWzTWM2OD1|Lk[3NVE1KM7:TR?= M1nmXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
BB49-HNC M{PTWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjKOppKSzVyPUOuO|A2ODhizszN M1XLS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
HCE-4 NFXrUFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTNwN{i2OFIh|ryP NH2xbGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
SK-LMS-1 M1jFemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrmTWM2OD1|LkizN|M5KM7:TR?= NHTMOIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
MS-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn2Z2ZKSzVyPUOuPFM4PzhizszN NFrrfVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
JAR M4LRTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIL5bIJKSzVyPUOuPVg5OzJizszN M4i4fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
KE-37 NWLzT4x3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTRwME[xOVgh|ryP NHjoW4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
LB996-RCC M3LCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK5TWM2OD12LkGyNVY5KM7:TR?= NFXL[Yo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
HH MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnic49KSzVyPUSuNlA6OTRizszN NHrNWWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
HL-60 MoLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\rWWlEPTB;ND6yNVA3PSEQvF2= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
HOP-62 M1i1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[yTWM2OD12LkOzOVIh|ryP NHvi[Gw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
NOMO-1 NVjOdIRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnkTHpRUUN3ME20MlM{Pjl7IN88US=> MlHuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
DU-4475 M2f0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHiTWM2OD12LkO2O|I6KM7:TR?= NVvwfGJGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
LC4-1 MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnr5TWM2OD12LkO4NFch|ryP NFrGTmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
MC116 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDLTWM2OD12LkSzNFgyKM7:TR?= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
SW982 NYHsVXVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\4NWlEPTB;ND61OVMxPyEQvF2= M{jyflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SK-N-DZ NWPSSW43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzyUIhKSzVyPUSuOlcxQTlizszN MkHaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
EW-1 NEXTN2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXTfHE5UUN3ME20MlY4QTFzIN88US=> MlX6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
SU-DHL-1 Ml3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTRwOECxO|Qh|ryP MmTmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
L-363 M2nodmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYSxUGdPUUN3ME20MlgxPjJzIN88US=> NH30[4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
OS-RC-2 M3r0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLPVlBKSzVyPUSuPFc{OSEQvF2= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
HD-MY-Z NX\1XFNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3ETWM2OD13LkG3N|AyKM7:TR?= NGrjVGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
MHH-PREB-1 M2m2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHP2d5RKSzVyPUWuN|I{OTJizszN MkfBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
HC-1 Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTRTWM2OD13LkSzNlkyKM7:TR?= M2LMS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SK-MM-2 NILMO|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTVwNEe4NkDPxE1? NUXVPGpKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
SH-4 NWHkW3ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfNN4Q4UUN3ME21MlQ5OzdizszN MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
MHH-CALL-2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonTTWM2OD13Lke2O|E6KM7:TR?= NFvDdWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
KG-1 NV;HO2xiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3ZTWM2OD14LkCyPFc5KM7:TR?= NFG4S3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
J-RT3-T3-5 NWT1bIx4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDJTWM2OD14LkC3PVA6KM7:TR?= NXTRNm9oRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
MMAC-SF M4\XOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nMNGlEPTB;Nj6xNFk1QSEQvF2= MmS3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
IST-SL2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn3XZAxUUN3ME22MlEzPTF7IN88US=> NFzLSpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
SW954 M1rTPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTZwMke1NVch|ryP NIP2NJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
HDLM-2 NID2U4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXGd3FKSzVyPU[uN|IyODlizszN MnvjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
ST486 NUTvO|dzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LEbWlEPTB;Nj6zOFcyKM7:TR?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
DG-75 NXvRS3N5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL4e5BuUUN3ME22MlQ{ODZ7IN88US=> NYH4XJozRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
EW-3 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rhe2lEPTB;Nj60N|IxPyEQvF2= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
8-MG-BA NWDlOG9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XEXWlEPTB;Nj61NVUxPyEQvF2= NHfvWXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
GT3TKB M1qyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTZwNkC3OlMh|ryP MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
KU812 M2TnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ezeGlEPTB;Nj62PVQzKM7:TR?= NWLydHNrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
CESS MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTdwMUC0N|gh|ryP NG[zVlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
BC-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i4OGlEPTB;Nz6yOFgyOiEQvF2= NFO4PII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
MZ1-PC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTdwM{CzPFkh|ryP MorLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NCI-H82 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHm1SIpKSzVyPUeuN|c5PSEQvF2= Mlv1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NCI-H1355 M37XTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTdwNEW4NFQh|ryP Mn\BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
RPMI-8226 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXHTWM2OD15LkWwO|M6KM7:TR?= MnnYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
ARH-77 NVjyVmtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;HfVFUUUN3ME23MlU{PTl5IN88US=> NEi2TZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
MN-60 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjRS4Q1UUN3ME23MlU1ODh6IN88US=> Mo\2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
IMR-5 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X4T2lEPTB;N{C1OFg4PiEQvF2= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
KARPAS-422 M1\aNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nNWGlEPTB;Nz61O|IxPiEQvF2= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
CA46 NXGydm05T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknhTWM2OD15LkW4NFEzKM7:TR?= Ml\kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
SJSA-1 Mor4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD6clljUUN3ME23MlY3ODZzIN88US=> MkjXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
no-11 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fOb2lEPTB;Nz63O|U2PyEQvF2= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
IST-SL1 NVPrbnhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{O5UmlEPTB;OD6wNlQyPyEQvF2= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
NCI-H209 MlnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRThwMUG2OVIh|ryP MmjOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
TALL-1 M2fL[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRThwMUizPFQh|ryP M3y0b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
KMOE-2 M2TJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3pTZNqUUN3ME24MlE6PDJizszN MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
HCC1599 NHHwOmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoX0TWM2OD16LkG5PVg4KM7:TR?= MnvRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
CI-1 M2DHUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\mbWlEPTB;OD6yNFQyOSEQvF2= NHnjfJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
NCI-H1304 NG[4cGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\n[mlEPTB;OD6yNFY3OSEQvF2= M{LPU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
Daudi NFnaSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PTUmlEPTB;OD6yN|U1PiEQvF2= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
CPC-N NIrhOm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO0NY1DUUN3ME24MlI6OTl7IN88US=> NEGwNHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
MC-CAR MoLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf1SpJPUUN3ME24MlM{PThizszN NYjXNnpjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
SW872 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLBTWM2OD16LkO0O|U5KM7:TR?= M1m0XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
OVCAR-4 M3LtW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moj2TWM2OD16LkWwN|UyKM7:TR?= MljsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
OCUB-M MnfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHZ[4lKSzVyPUiuOVY2ODhizszN NXHve45yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
SK-PN-DW M3TvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnWTZZKSzVyPUiuOlA6QDVizszN MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
NCCIT MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRThwN{G3OFUh|ryP M17EZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NCI-H1648 M3y2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ezSmlEPTB;OT6xN|g{PCEQvF2= NGXQ[Hg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
COR-L279 NXr5UIlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTlwM{mwPUDPxE1? MmG3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
LS-123 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nL[2lEPTB;OT62PFE3OSEQvF2= NGrPfG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
LP-1 NIX3cmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTlwN{iwPFMh|ryP NXXwV5F2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NB13 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjXTWM2OD17Lke5PVk1KM7:TR?= Ml3kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
ONS-76 NUfNTIt3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoT1TWM2OD17LkixNFE3KM7:TR?= MonRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
VA-ES-BJ MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LzTGlEPTB;OT65PVk{OyEQvF2= NUnEcYJnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
GR-ST MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HJW2lEPTB;MUCuNlIxPyEQvF2= M{e0eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
ES1 Mn\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrONlJKSzVyPUGwMlI6QDRizszN M3Gyd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NB14 M2izR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jQfGlEPTB;MUCuPVI4PyEQvF2= NUjqOIpMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
Ramos-2G6-4C10 MnLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTFzLkK2OUDPxE1? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
RXF393 NI\xOXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDydJM4UUN3ME2xNU41QDN2IN88US=> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
NCI-H2107 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2KzS2lEPTB;MUGuOVk5PCEQvF2= MoK3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
K562 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUK4U202UUN3ME2xNU45PzB{IN88US=> M4mxVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
LOUCY NWDhcnFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3u0WWlEPTB;MUGuPVg4PSEQvF2= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
TGBC1TKB NGj4Ro1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;TTWM2OD1zMj6wNFIh|ryP M2fuXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
COLO-320-HSR NV7vZWl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTF{LkG1OlUh|ryP MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
K5 M1r4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPpTWM2OD1zMj6yPVg2KM7:TR?= NFzF[5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
BC-3 NGDh[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTF{LkS2OVEh|ryP NUHIPJdZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
REH NFjVOYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLKT5JjUUN3ME2xNk43PDl6IN88US=> MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
NEC8 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\VXmc{UUN3ME2xNk43QDh5IN88US=> M1rnRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
IST-MEL1 Mo\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTF{Lki2PVQh|ryP M4jRWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NCI-H128 M3j1fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTF|LkC3NlMh|ryP MnvCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NCI-H1694 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTF|LkGxOFQh|ryP NHjMSZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
TGW NVridpZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTF|LkOyO|Yh|ryP MnPkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NCI-SNU-1 NGnOfGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;admlEPTB;MUOuN|Q2KM7:TR?= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
IST-MES1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LifmlEPTB;MUOuOlczQSEQvF2= M37PdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
CTB-1 NIXrOmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLifog6UUN3ME2xN{44Ojl2IN88US=> M1\xNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
HUTU-80 NUL6NZhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrsTWM2OD1zMz63OVc{KM7:TR?= M{jqW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
LAN-6 NIi3N4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HVSGlEPTB;MUSuNlQ2PyEQvF2= NIPrSJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
KP-N-YS M{\SS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTF2LkK4PVQh|ryP MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
CCRF-CEM NXzWepdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17lSmlEPTB;MUSuOFE3QSEQvF2= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
NCI-H1770 MknvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4e0fmlEPTB;MUSuOVM3QSEQvF2= MoftQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
MZ2-MEL NXS3dWRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTF3LkKyOVEh|ryP NXX3ToVMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
COR-L88 MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzUTWM2OD1zNj6wNFEzKM7:TR?= MoTmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
LOXIMVI Mk[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm5TWM2OD1zNj6yOVYh|ryP NUnOSllLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
KALS-1 M1XVNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTF4LkW5N|Eh|ryP NIHvXI89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
D-283MED MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NICyc3FKSzVyPUG2Mlg1QDlizszN M4jKcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NCI-H719 NUTSN4lrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\5XYVvUUN3ME2xOk46OTZzIN88US=> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
MLMA NWD5R4ZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGj0eJlKSzVyPUG2Mlk6ODdizszN MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
EVSA-T MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjxTWM2OD1zNz6wOFg2KM7:TR?= M{\jRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SK-N-FI NXjwfnM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LN[WlEPTB;MUeuOlkyOyEQvF2= MkK1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NTERA-S-cl-D1 MmD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\IO5dKSzVyPUG3Mlg2PzJizszN MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
NCI-H1882 M1fWRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTF5Lkm4N|Qh|ryP NVj6flZURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
A704 Mn61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnntTWM2OD1zNz65PVA1KM7:TR?= MlSyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
L-428 NV\EcJVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTF6LkCxOVEh|ryP NES0eII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
HCC1187 Mn61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz3TWM2OD1zOD6wNVg4KM7:TR?= NXTV[Wp6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-H1581 MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PpS2lEPTB;MUiuNFg3PiEQvF2= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
BB65-RCC MnPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzTbnp1UUN3ME2xPE41OTZ{IN88US=> M{DVSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
EM-2 NUP6OlJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;HV5hqUUN3ME2xPE42Pjd{IN88US=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
Raji NGDjbo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7w[4l2UUN3ME2xPU46PTZ3IN88US=> M3[5ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
TE-1 NWXsfollT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkGwTWM2OD1{MD60NVA1KM7:TR?= MmX2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
SW962 NIXkboZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTQSZdyUUN3ME2yNE41Ojl|IN88US=> NVHa[mU2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
MHH-NB-11 M3XZT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofOTWM2OD1{MD61OVIyKM7:TR?= NHnSWnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
no-10 M{XIOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETBNW5KSzVyPUKxMlAzPjRizszN MoDZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
GDM-1 NVrTbnVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJzLkm0NVQh|ryP NHj6fXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
KMS-12-PE NGLpN5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmixTWM2OD1{Mj6yO|Qh|ryP MoTBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NCI-H510A MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LmN2lEPTB;MkSuNVI4QCEQvF2= M3zaVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
ES5 MmrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPvTWM2OD1{ND63N|Q6KM7:TR?= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
JiyoyeP-2003 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvMXXpjUUN3ME2yOk4zPzR{IN88US=> M4frb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NMC-G1 M{XGW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYH0eZVLUUN3ME2yO{4yQDJ{IN88US=> NUHy[ZRLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-H446 M{npfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7FfpBKSzVyPUK3MlQ6PDZizszN NIW2XJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
NB7 NEDUTFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;3emlEPTB;MkeuPVIzQSEQvF2= MkPLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
A388 MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4ewb2lEPTB;MkiuNFA4PCEQvF2= NFPSN4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
JVM-2 MkLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEH1RmFKSzVyPUK4MlI5QThizszN NYC1V2M4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
HT-144 MlnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnNTWM2OD1{OD62PUDPxE1? MnHsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NCI-H747 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrObZpwUUN3ME2yPE46OTl3IN88US=> NX60bI5{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-H1650 NUKwXWdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2r5OGlEPTB;MkmuNFE4PiEQvF2= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
EB-3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJ7LkWzNFkh|ryP M4PwcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
KLE NGfv[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILIUmhKSzVyPUK5MlYyQSEQvF2= NXP0[mVoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
TK10 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzaVIJnUUN3ME2zNE4yOjZizszN MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
COLO-668 NIfEdXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DjR2lEPTB;M{CuO|kzKM7:TR?= MlTmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NCI-H23 NV3xRnp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml2wTWM2OD1|MT6xNFY{KM7:TR?= NYPtSXlNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
GOTO MkXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnkR4tTUUN3ME2zNU43ODh3IN88US=> M2n0O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
MSTO-211H NWO3VGRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTNzLki2O|gh|ryP MlK1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
LB831-BLC MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTGTWM2OD1|Mj6zPFQ{KM7:TR?= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
SCH NIPYNZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\RWHFvUUN3ME2zNk45PDh3IN88US=> NVPMb2JFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
EHEB MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTN2LkGxPVMh|ryP M3fsNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
U-266 MoXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTN2LkK3PFEh|ryP NX3qS2VMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
EW-11 NEno[nBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTN2LkS3NlUh|ryP MkDyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
TE-9 MonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfofYJKSzVyPUO3MlA1ODFizszN NH3WcXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
ES3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDEUW5KSzVyPUO3MlUxODRizszN NULVcY5URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-H2141 MmXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPKVHRGUUN3ME2zPE4xQDR|IN88US=> MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
MPP-89 M4W5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHIdHVKSzVyPUSyMlA2QDZizszN M2rKUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SK-MEL-2 M1ixdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPxTWM2OD12Mj62OFA2KM7:TR?= NIrPZ4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
LC-1F MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3HbJBKSzVyPUSzMlM3QDJizszN M3TlflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NH-12 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTR|LkmzOVkh|ryP MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
RKO NVPoeWcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XSOmlEPTB;NESuNVI2OiEQvF2= NV60THlbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
KM-H2 NWD4[nZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXqwSpdwUUN3ME20OE46PTd5IN88US=> M3HtOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SK-UT-1 M2frN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLiV4dKSzVyPUS5Mlg5OjVizszN Mn7VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-STAT3 / STAT3 / p-Src / Src / p-AKT / AKT / p-ERK / ERK ; 

PubMed: 19244102     


Sunitinib reduced Stat3 and Src activity, with no dramatic reduction of AKT, MAPK and JAK signaling in 786-O cells. Tumor cells were treated with sunitinib at indicated concentrations for 2 h (left panels) or 24 h (right panels). Total cell lysates were prepared and western blots were performed using relevant antibodies to detect total protein levels, with β-actin used as the loading control.

p-GSK3β / GSK3β / MYCN ; 

PubMed: 24759734     


Effect of sunitinib on GSK3β phosphorylation and on MYCN total protein in MYCN amplified NB cell lines.

p-AKT / AKT / p-ERK / ERK; 

PubMed: 24759734     


Effect of 72 h treatment with sunitinib on SH-SY5Y, SK N BE(2), SK-N-AS and IMR-32 NB cell lines analyzed by Western blot with pSer473Akt, Akt, pThr202/Thr204 Erk1/2 and Erk1/2 antibodies. β-actin was used as a loading control.

19244102 24759734
Growth inhibition assay
Cell viability; 

PubMed: 24369536     


Isolated effects of sunitinib malate on urinary bladder-cancer cell lines viability, assessed by using the MTT assay. The data shown and bars represent the mean values ± SD (SD: standard deviation). *P < 0.05 versus untreated cells.

24369536
In vivo

Consistent with the substantial and selective inhibition of VEGFR2 or PDGFR phosphorylation and signaling in vivo, Sunitinib (20-80 mg/kg/day) exhibits broad and potent dose-dependent anti-tumor activity against a variety of tumor xenograft models including HT-29, A431, Colo205, H-460, SF763T, C6, A375, or MDA-MB-435. Sunitinib dosing at 80 mg/kg/day for 21 days leads to complete tumor regression in six of eight mice, without tumor re-growing during a 110-day observation period after the end of treatment. Second round of treatment with Sunitinib remains efficacious against tumors that are not fully regressed during the first round of treatment. Sunitinib treatment results in significant decrease in tumor MVD, with ~40% reduction in SF763T glioma tumors. SU11248 treatment results in a complete inhibition of additional tumor growth of luciferase-expressing PC-3M xenografts, despite no reduction in tumor size. [2] Sunitinib treatment (20 mg/kg/day) dramatically suppresses the growth subcutaneous MV4;11 (FLT3-ITD) xenografts and prolongs survival in the FLT3-ITD bone marrow engraftment model. [3]

Protocol

Kinase Assay:

[1]

- Collapse

Biochemical Tyrosine Kinase Assays:

IC50 values for Sunitinib against VEGFR2 (Flk-1) and PDGFRβ are determined using glutathione S-transferasefusion proteins containing the complete cytoplasmic domain of the RTK. Biochemical tyrosine kinase assays to quantitate the trans-phosphorylation activity of VEGFR2 (Flk-1) and PDGFRβ are performed in 96-well microtiter plates precoated (20 μg/well in PBS; incubated overnight at 4 °C) with the peptide substrate poly-Glu,Tyr (4:1). Excess protein binding sites are blocked with the addition of 1-5% (w/v) BSA in PBS. Purified GST-fusion proteins are produced in baculovirus-infected insect cells. GST-VEGFR2 and GST-PDGFRβ are then added to the microtiter wells in 2 × concentration kinase dilution buffer consisting of 100 mM HEPES, 50 mM NaCl, 40 μM NaVO4, and 0.02% (w/v) BSA. The final enzyme concentration for GST-VEGFR2 or GST-PDGFRβ is 50 ng/mL. Twenty-five μL of diluted Sunitinib are subsequently added to each reaction well to produce a range of inhibitor concentrations appropriate for each enzyme. The kinase reaction is initiated by the addition of different concentrations of ATP in a solution of MnCl2 so that the final ATP concentrations spanned the Km for the enzyme, and the final concentration of MnCl2 is 10 mM. The plates are incubated for 5-15 minutes at room temperature before stopping the reaction with the addition of EDTA. The plates are then washed three times with TBST. Rabbit polyclonal antiphosphotyrosine antisera are added to the wells at a 1:10,000 dilution in TBST containing 0.5% (w/v) BSA, 0.025% (w/v) nonfat dry milk, and 100 μM NaVO4 and incubated for 1 hour at 37 °C. The plates are then washed three times with TBST, followed by the addition of goat antirabbit antisera conjugated with horseradish peroxidase (1:10,000 dilution in TBST). The plates are incubated for 1 hour at 37 °C and then washed three times with TBST. The amount of phosphotyrosine in each well is quantitated after the addition of 2,2′-azino-di-[3-ethylbenzthiazoline sulfonate] as substrate.
Cell Research:

[3]

- Collapse
  • Cell lines: RS4;11, MV4;11, and OC1-AML5
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 24 and 48 hours
  • Method:

    Cells are starved overnight in medium containing 0.1% FBS prior to addition of Sunitinib and FL (50 ng/mL; FLT3-WT cells only). Proliferation is measured after 48 hours of culture using the Alamar Blue assay or trypan blue cell viability assays. Apoptosis is measured 24 hours after Sunitinib addition by Western blotting to detect cleavage of poly (ADP-ribose) polymerase (PARP) or levels of caspase-3.


    (Only for Reference)
Animal Research:

[2]

- Collapse
  • Animal Models: Female nu/nu mice implanted s.c. with HT-29, A431, Colo205, H-460, SF763T, C6, A375, or MDA-MB-435, and male nu/nu mice bearing luciferase-expressing PC-3M tumors
  • Dosages: ~80 mg/kg
  • Administration: Orally once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 15 mg/mL (28.16 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C22H27FN4O2.C4H6O5

CAS No. 341031-54-7
Storage powder
in solvent
Synonyms N/A
Smiles CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04669366 Recruiting Drug: sunitinib|Drug: axitinib Kidney Neoplasms Pfizer January 20 2021 --
NCT04633122 Recruiting Drug: Ripretinib|Drug: Sunitinib Gastrointestinal Stromal Tumor(GIST) Zai Lab (Shanghai) Co. Ltd. November 25 2020 Phase 2
NCT04115189 Completed Drug: Sunitinib Metastatic Renal Cell Carcinoma ( mRCC) Pfizer December 13 2019 --
NCT03916458 Completed -- Carcinoma Renal Cell Pfizer December 17 2019 --
NCT04175262 Completed Drug: sunitinib Metastatic Renal Cell Carcinoma (mRCC) Pfizer|IMDC group|Analysis Group October 31 2019 --
NCT04033991 Completed Drug: Sunitinib|Drug: Axitinib Carcinoma|Renal Cell Pfizer September 27 2019 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I was wondering that the compound is in its cis or trans form?

  • Answer:

    S1042 Sunitinib Malate is Z form.

  • Question 2:

    What is the difference between Sunitinib Malate(S1042) and Sunitinib(S7781)?

  • Answer:

    S1042 is the Malate salt form of Sunitinib. The biological activities of these two compounds are the same but the solubility of these two compounds in aqueous solvent are different.

PDGFR Signaling Pathway Map

PDGFR Inhibitors with Unique Features

Related PDGFR Products

Tags: buy Sunitinib (SU11248) malate | Sunitinib (SU11248) malate supplier | purchase Sunitinib (SU11248) malate | Sunitinib (SU11248) malate cost | Sunitinib (SU11248) malate manufacturer | order Sunitinib (SU11248) malate | Sunitinib (SU11248) malate distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID