Sunitinib (SU11248) malate

Name: Sunitinib (SU11248) malate
Brand: Selleck Chemicals
SKU: S1042
Rating: 5 (119 reviews)

For research use only.

Licensed by Pfizer Catalog No.S1042

119 publications

Sunitinib (SU11248) malate Chemical Structure

CAS No. 341031-54-7

Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.

Selleck's Sunitinib (SU11248) malate has been cited by 119 publications

Cell, 2019, 36(2):179-193

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Cancer Cell, 2019, 36(2):179-193

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Nature, 2011, 478(7369):349-55

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Adv Sci (Weinh), 2021, 8(2):2001596

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Blood Cancer J, 2021, 11(3):57

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Autophagy, 2021, 1-22

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Cancers (Basel), 2021, 13(11)2574

PubMed: 34073906 ( click the link to review the publication )

Cancers (Basel), 2021, 13(14)3586

PubMed: 34298802 ( click the link to review the publication )

J Clin Endocrinol Metab, 2021, dgab020

PubMed: 33524147 ( click the link to review the publication )

Front Oncol, 2021, 11:648097

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Toxicol Sci, 2021, kfab033

PubMed: 33749749 ( click the link to review the publication )

ACS Biomater Sci Eng, 2021, 7(6):2569-2579

PubMed: 34061498 ( click the link to review the publication )

Sci Rep, 2021, 11(1):12148

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Sci Rep, 2021, 11(1):10200

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Cancer Gene Ther, 2021, 10.1038/s41417-021-00345-1

PubMed: 34088993 ( click the link to review the publication )

Drug Metab Dispos, 2021, 49(1):53-61

PubMed: 33148688 ( click the link to review the publication )

Int J Oncol, 2021, 59(1)48

PubMed: 34036385 ( click the link to review the publication )

Transl Oncol, 2021, 14(7):101099

PubMed: 33887553 ( click the link to review the publication )

PLoS One, 2021, 16(7):e0253258

PubMed: 34234354 ( click the link to review the publication )

Oncol Lett, 2021, 21(4):294

PubMed: 33732370 ( click the link to review the publication )

Hum Cell, 2021, 10.1007/s13577-021-00579-z

PubMed: 34304386 ( click the link to review the publication )

Mol Med Rep, 2021, 23(1)40

PubMed: 33179075 ( click the link to review the publication )

NAT CANCER, 2021, 2, 201–217

PubMed: None ( click the link to review the publication )

Biomedicines, 2021, 9(6)627

PubMed: 34072926 ( click the link to review the publication )
Int J Breast Cancer, 2021, 2021:8818393

PubMed: 33936816 ( click the link to review the publication )

Eur J Pharmacol, 2021, 895:173868

PubMed: 33460613 ( click the link to review the publication )

Cancers (Basel), 2021, 13(4)653

PubMed: 33562152 ( click the link to review the publication )

Nat Protoc, 2020, 15(2):421-449

PubMed: 31932771 ( click the link to review the publication )

Cancer Res, 2020, canres.1992.2020

PubMed: 33203698 ( click the link to review the publication )

J Clin Med, 2020, 9(3)

PubMed: 32131507 ( click the link to review the publication )

Front Oncol, 2020, 10:516552

PubMed: 33072561 ( click the link to review the publication )

J Cell Mol Med, 2020, 24(24):14441-14452

PubMed: 33145941 ( click the link to review the publication )

Cancer Cell Int, 2020, 19;20:58

PubMed: 32099531 ( click the link to review the publication )

Metabolites, 2020, 11(1)E1

PubMed: 33374949 ( click the link to review the publication )

PLoS One, 2020, 15(8):e0232917

PubMed: 32810161 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00420-z

PubMed: 32870449 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00425-8

PubMed: 32886306 ( click the link to review the publication )

Neoplasia, 2020, 22(10):470-483

PubMed: 32818841 ( click the link to review the publication )

Cell Syst, 2019, 8(2):97-108

PubMed: 30797775 ( click the link to review the publication )

FASEB J, 2019, 33(1):1347-1359

PubMed: 30148679 ( click the link to review the publication )

Oncoimmunology, 2019, 8(2):e1543526

PubMed: 30713805 ( click the link to review the publication )

Biomolecules, 2019, 9(11)

PubMed: 31683643 ( click the link to review the publication )

Expert Opin Ther Targets, 2019, 23(9):805-817

PubMed: 31385548 ( click the link to review the publication )

IEEE Trans Biomed Eng, 2019, 66(3):873-880

PubMed: 30059292 ( click the link to review the publication )

Sci Rep, 2019, 9(1):6004

PubMed: 30979919 ( click the link to review the publication )

Sci Rep, 2019, 9(1):1897

PubMed: 30760778 ( click the link to review the publication )

Oncol Rep, 2019, 42(5):2039-2048

PubMed: 31485624 ( click the link to review the publication )

AAPS PharmSciTech, 2019, 20(7):281

PubMed: 31399890 ( click the link to review the publication )
Pharm Biol, 2019, 57(1):625-631

PubMed: 31545912 ( click the link to review the publication )

Theranostics, 2018, 8(1):141-155

PubMed: 29290798 ( click the link to review the publication )

EBioMedicine, 2018, 27:225-236

PubMed: 29289530 ( click the link to review the publication )

Cancers (Basel), 2018, 10(10)E365

PubMed: 30274248 ( click the link to review the publication )

Endocr Relat Cancer, 2018, 25(4):471-480

PubMed: 29440231 ( click the link to review the publication )

J Lipid Res, 2018, 59(11):2188-2201

PubMed: 30173145 ( click the link to review the publication )

Chem Biol Interact, 2018, 294:1-8

PubMed: 30125546 ( click the link to review the publication )

Transl Oncol, 2018, 11(6):1406-1418

PubMed: 30219696 ( click the link to review the publication )

Cancer Chemother Pharmacol, 2018, 82(1):65-75

PubMed: 29721849 ( click the link to review the publication )

Cell Death Dis, 2018, 9(10):1018

PubMed: 30282966 ( click the link to review the publication )

Assay Drug Dev Technol, 2018, 16(7):408-419

PubMed: 29985634 ( click the link to review the publication )

J Clin Invest, 2017, 127(4):1338-1352

PubMed: 28240606 ( click the link to review the publication )

Cancer Res, 2017, 77(4):1008-1020

PubMed: 28011623 ( click the link to review the publication )

Arch Toxicol, 2017, 91(8):2921-2938

PubMed: 28032146 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(11):2502-2515

PubMed: 28729403 ( click the link to review the publication )

Hum Mol Genet, 2017, 26(22):4375-4387

PubMed: 28973155 ( click the link to review the publication )

J Am Heart Assoc, 2017, 6(10)

PubMed: 29051215 ( click the link to review the publication )

J Biol Chem, 2017,

PubMed: 27903634 ( click the link to review the publication )

Oncotarget, 2017, 8(40):68270-68279

PubMed: 28978115 ( click the link to review the publication )

Oncotarget, 2017, 8(13):20881-20894

PubMed: 28152509 ( click the link to review the publication )

Oncotarget, 2017, 9(1):802-811

PubMed: 29416656 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2016, 113(33):9339-44

PubMed: 27482107 ( click the link to review the publication )

Elife, 2016, 5e11405

PubMed: 27841748 ( click the link to review the publication )

Oncogene, 2016, 35(21):2687-97

PubMed: 26364599 ( click the link to review the publication )
Cancer Lett, 2016, 374(2):250-60

PubMed: 26921131 ( click the link to review the publication )

Dis Esophagus, 2016, 29(8):1144-1151

PubMed: 26542732 ( click the link to review the publication )

Oncol Lett, 2016, 12(6):4671-4676

PubMed: 28105174 ( click the link to review the publication )

Oncotarget, 2016, 7(29):45015-45026

PubMed: 27304187 ( click the link to review the publication )

Sci Transl Med, 2015, 7(284):284ra57

PubMed: 25904741 ( click the link to review the publication )

Neurobiol Dis, 2015, 74:114-25

PubMed: 25461258 ( click the link to review the publication )

Exp Cell Res, 2015, 332(1):1-10

PubMed: 25637219 ( click the link to review the publication )

Biochem Biophys Res Commun, 2015, 10.1016/j.bbrc.2015.04.107

PubMed: 25935484 ( click the link to review the publication )

Pulm Pharmacol Ther, 2015, 10.1016/j.pupt.2015.03.001

PubMed: 25843005 ( click the link to review the publication )

Clin Cancer Res, 2014, 20(9):2410-23

PubMed: 24573550 ( click the link to review the publication )

Leukemia, 2014, 28(11):2197-205

PubMed: 24699302 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2014, 111(14):5319-24

PubMed: 24623852 ( click the link to review the publication )

Ann Surg, 2014, 259(4):793-9

PubMed: 24045439 ( click the link to review the publication )

Int J Cancer, 2014, 10.1002/ijc.29414

PubMed: 25556636 ( click the link to review the publication )

Oncogene, 2014, 33(19):2531-9

PubMed: 23728343 ( click the link to review the publication )

Br J Pharmacol, 2014, 171(24):5728-42

PubMed: 25091695 ( click the link to review the publication )

Br J Cancer, 2014, 111(6):1168-7

PubMed: 25093491 ( click the link to review the publication )

Neurobiol Dis, 2014, 10.1016/j.nbd.2014.10.024

PubMed: ( click the link to review the publication )

Cancer Cell Int, 2014, 14(1):89

PubMed: 25253994 ( click the link to review the publication )

Cancer Cell Int, 2014, 14:89

PubMed: ( click the link to review the publication )

Drug Metab Dispos, 2014, 42(11):1851-7

PubMed: 25165131 ( click the link to review the publication )

Cell Cycle, 2014,

PubMed: 25426675 ( click the link to review the publication )

Cell Cycle, 2014, 13(24):3808-17

PubMed: ( click the link to review the publication )

Transl Oncol, 2014, 19(9):2368-80

PubMed: 23633458 ( click the link to review the publication )
PLoS One, 2014, 9(4):e96024

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PLoS One, 2014, 9(1):e85759

PubMed: 24454929 ( click the link to review the publication )

Korean J Parasitol, 2014, 52(4):439-41

PubMed: 25246725 ( click the link to review the publication )

Oncotarget, 2014, 5(16):6801-15

PubMed: 25149535 ( click the link to review the publication )

Cytometry A, 2014, 85(6):537-47

PubMed: 24664821 ( click the link to review the publication )

Cancer Res, 2013, 73(23):6886-99

PubMed: 24145351 ( click the link to review the publication )

Cancer Lett, 2013, 340(1):43-50

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Mol Cancer Ther, 2013, 12(10):2018-30

PubMed: 23920274 ( click the link to review the publication )

Apoptosis, 2013, 19(4):682-97

PubMed: 24337903 ( click the link to review the publication )

Mol Cell Endocrinol, 2013, 377(1-2):1-6

PubMed: 23811235 ( click the link to review the publication )

Acta Oncol, 2013, 53(5):637-45

PubMed: 24041258 ( click the link to review the publication )

Am J Nucl Med Mol Imaging, 2013, 3(5):397-407

PubMed: 24116348 ( click the link to review the publication )

SENSOR ACTUAT B-CHEM, 2012, Jin Akagi

PubMed: ( click the link to review the publication )

Surgery, 2012, 152(6):1045-50

PubMed: 23102636 ( click the link to review the publication )

Surgery, 2012, 152(6):1142-9

PubMed: 23158184 ( click the link to review the publication )

J Biomol Screen, 2012, 17(6):813-21

PubMed: 22453235 ( click the link to review the publication )

J Biomol Screen, 2012, 18(4):388-99

PubMed: 23134735 ( click the link to review the publication )

Cell Res, 2011, 21(7):1080-7

PubMed: 21423276 ( click the link to review the publication )

Cancer Res, 2011, 71(5):1637-46

PubMed: 21343392 ( click the link to review the publication )

Mol Cancer Ther, 2011, 10(10):1897-908

PubMed: 21825009 ( click the link to review the publication )

Blood, 2010, 115(23):4725-33

PubMed: 20185585 ( click the link to review the publication )

Dis Model Mech, 2010, 3(5-6):343-53

PubMed: 20335444 ( click the link to review the publication )

Biochem Bioph Res Co, 2010, 398(2):205-11

PubMed: 20599738 ( click the link to review the publication )

Purity & Quality Control

Choose Selective PDGFR Inhibitors

Biological Activity

Description

Targets

IRE1α ^[7] ()	Kit ^[1] (Cell-free assay)	FLT3 ^[1] (Cell-free assay)	PDGFRβ ^[1] (Cell-free assay)	VEGFR2 ^[1] (Cell-free assay)
			2 nM	80 nM

In vitro

Sunitinib also potently inhibits Kit and FLT-3. ^[1] Sunitinib is a potent ATP-competitive inhibitor of VEGFR2 (Flk1) and PDGFRβ with K_i of 9 nM and 8 nM, respectively, displaying >10-fold higher selectivity for VEGFR2 and PDGFR than FGFR-1, EGFR, Cdk2, Met, IGFR-1, Abl, and src. In serum-starved NIH-3T3 cells expressing VEGFR2 or PDGFRβ, Sunitinib inhibits VEGF-dependent VEGFR2 phosphorylation and PDGF-dependent PDGFRβ phosphorylation with IC50 of 10 nM and 10 nM, respectively. Sunitinib inhibits VEGF-induced proliferation of serum-starved HUVECs with IC50 of 40 nM, and inhibits PDGF-induced proliferation of NIH-3T3 cells overexpressing PDGFRβ or PDGFRα with IC50 of 39 nM and 69 nM, respectively. ^[2] Sunitinib inhibits phosphorylation of wild-type FLT3, FLT3-ITD, and FLT3-Asp835 with IC50 of 250 nM, 50 nM, and 30 nM, respectively. Sunitinib inhibits the proliferation of MV4;11 and OC1-AML5 cells with IC50 of 8 nM and 14 nM, respectively, and induces apoptosis in a dose-dependent manner. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
3T3	MkHQT4lv[XOnIFHzd4F6				MXHJcohq[mm2aX;uJI9nKFCGR1[tbY5lfWOnZDDCdoRWKGmwY3;ydI9z[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEC3JO69VQ>?	M1XLclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkS2NFE6Lz5zMk[0OlAyQTxxYU6=
3T3	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWHUWpBLUW6qaXLpeIlwdiCxZjDQcIF1\WyndD3k[ZJqfmWmIHfyc5d1cCCoYXP0c5IhcW6mdXPl[EA{XDNiY3XscEBxem:uaX\ldoF1cW:wIIfpeIghUUN3MDDv[kAxNjBzIN88US=>	NHLOXHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[0OlAyQSd-MUK2OFYxOTl:L3G+
3T3	MoD5SpVv[3Srb36gRZN{[Xl?				NHf3WGZKdmirYnn0bY9vKG:oIG\hd4N2dGG{IHXu[I91cGWuaXHsJIdzd3e2aDDmZYN1d3JicnXj[ZB1d3Jid3n0bEBKSzVyIH;mJFAvODVizszN	NFPvWYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[0OlAyQSd-MUK2OFYxOTl:L3G+
3T3	NF3O[XVMcW6jc3WgRZN{[Xl?		M12zNVIxKG2rbh?=	NFTTNFJFVVOR	MlXwR4VtdHWuYYKgbY5pcWKrdHnvckBw\iCYRVfGJIlv\HWlZXSgbJVu[W5iS1TSJJBpd3OyaH;yfYxifGmxbjD3bZRpKEmFNUCgc4YhOC5yMkKg{txO	NV\Lc5lVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[xOlIxODhpPkG2NVYzODB6PD;hQi=>
NIH3T3	M2rLRmtqdmG\|ZTDBd5NigQ>?		M{faTVIxKG2rbh?=	NVyzcGw5TE2VTx?=	NXOxT\|hjcW6qaXLpeEBpfW2jbjDLSHIhc2mwYYPlJIV5eHKnc4Pl[EB4cXSqIFnDOVAhd2ZiMD6wNVgh\|ryP	NH71bWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkG2NlAxQCd-MU[xOlIxODh:L3G+
A549	MXvGeY5kfGmxbjDBd5NigQ>?			MnXSSG1UVw>?	NWW3eHRiUW6qaXLpeIlwdiCxZjDjMW1mfCCmZYDlcoRmdnRiSFfGMYlv\HWlZXSgbJVu[W5iQUW0PUBk\WyuIH3p[5JifGmxbjD3bZRpKEmFNUCgc4YhOiEQvF2=	NH7zNm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOESzOFE1PSd-MUi0N\|QyPDV:L3G+
DU145	NV\lfWJDTnWwY4Tpc44hSXO\|YYm=			NVjSUI9xTE2VTx?=	NYftZ3V[UW6qaXLpeIlwdiCxZjDjMW1mfCCmZYDlcoRmdnRiSFfGMYlv\HWlZXSgbJVu[W5iRGWxOFUh[2WubDDzZ4F1fGW{aX7nJJdqfGhiSVO1NEBw\iBzMDFOwG0>	MnjiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2M{SxOFUoRjF6NEO0NVQ2RC:jPh?=
KB3-1	NU\DeFJpS3m2b4TvfIlkKEG\|c3H5		NGTGOXk4OiCq	Mli0SG1UVw>?	MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQMYdxNW6nZ3H0bZZmKEuELUOtNUBk\WyuczD3bZRpKEmFNUCgc4YhOi5\|IN88US=>	MoH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|OUezNlIoRjF7M{m3N\|IzRC:jPh?=
KBV1	NWWxVnpsS3m2b4TvfIlkKEG\|c3H5		M4Hre\|czKGh?	NFXuUHJFVVOR	NHTofXJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRNWeueXPvdJJwfGWrbj3lfJBz\XO\|aX7nJGtDXjFiY3XscJMhf2m2aDDJR\|UxKG:oIESuNUDPxE1?	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7N{OyNkc,OTl\|OUezNlI9N2F-
A375	MkXOR5l1d3SxeHnjJGF{e2G7		MofCO\|IhcA>?	NHnQNXJFVVOR	NITlfY5KSzVyPUWuOEDPxE1?	NEDGXpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[1OFQxQCd-MUm2OVQ1ODh:L3G+
RS4-11	MWTGeY5kfGmxbjDBd5NigQ>?		MW[yJIg>		MkXzTY5pcWKrdHnvckBw\iCITGSzJIF2fG:yaH;zdIhwenmuYYTpc44hf2m2aDDJR\|UxKG:oIECuNFA6QSEQvF2=	Mn3jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4NUS0NFgoRjF7NkW0OFA5RC:jPh?=
RS4-11	M{jyemZ2dmO2aX;uJGF{e2G7		MlTYNkBp		NIPzXYdKdmirYnn0bY9vKG:oIF\MWFMhUVSGIH31eIFvfCCjdYTvdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjB\|NDFOwG0>	MmH0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4NUS0NFgoRjF7NkW0OFA5RC:jPh?=
Sf9	NXPOUIxDU2mwYYPlJGF{e2G7		Mn76N\|AhdWmw		NEHTZmVKdmirYnn0bY9vKG:oIFfTWE11[WepZXSgWmVITlJiZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAxNjF6NTFOwG0>	MlywQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6NUSwOVEoRjF7OEW0NFUyRC:jPh?=
Ba/F3	M{HCeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NYTQcZVLPzJiaB?=		NWO2cINZUUN3ME2xMlIh\|ryP	Mn7BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMUewNFQoRjJyMUG3NFA1RC:jPh?=
BaPTC2	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NVyye5k1PzJiaB?=		MVHJR\|UxRTBwMkKg{txO	M3TJ[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUG3NFA1Lz5{MEGxO\|AxPDxxYU6=
Sf9	NF7vd25HfW6ldHnvckBCe3OjeR?=		NF;BNnYyKGh?	MmjoSG1UVw>?	NVz3NZJVUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDIbZMufGGpZ3XkJHJGXCCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFEvOyEQvF2=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODFzN{CwOEc,OjBzMUewNFQ9N2F-
H4	MXvDfZRwfG:6aXOgRZN{[Xl?	NHfjU2UyOCEQvF2=			M{TSe3RwgGmlaYT5JIlvKGi3bXHuJGg1KGOnbHzz	M2f5bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPFA3Lz5{MEO1NFgxPjxxYU6=
SF-539	MYTLbY5ie2ViQYPzZZk>	M4f0O\|M{OyEQvF2=	MkfPOlAhdWmw	NXmyUXNSTE2VTx?=	M2HOcGlvcGmkaYTpc44hd2ZiUFTHSnJj\XSjIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNVIvOiEQvF2=	MkC0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2MEO3NFAoRjJyNECzO\|AxRC:jPh?=
U251	M{\xcWtqdmG\|ZTDBd5NigQ>?	MonDN\|M{KM7:TR?=	MXy2NEBucW5?	M3XrW2ROW09?	MVPJcohq[mm2aX;uJI9nKF[HR1\SNkBxcG:\|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDF6Lkmg{txO	Moe3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2MEO3NFAoRjJyNECzO\|AxRC:jPh?=
A431	M1f2TGtqdmG\|ZTDBd5NigQ>?				NYPEfWZRUW6qaXLpeIlwdiCxZjDQSGdHWmKndHGg[ZhxemW\|c3XkJJdqfGhiSVO1NEBw\iBzMj6yJO69VQ>?	M33BfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUW4NFczLz5{MEW1PFA4OjxxYU6=
A431	M3G2cmtqdmG\|ZTDBd5NigQ>?				MkjnTY5pcWKrdHnvckBw\iCYRVfGVlIh\XiycnXzd4VlKHerdHigTWM2OCCxZjCxPE46KM7:TR?=	NHrjdWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEW1PFA4Oid-MkC1OVgxPzJ:L3G+
HepG2	NHzDWVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MoDiO\|IhcA>?		NFz0cHZKSzVyPUOuPFEh\|ryP	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODV5MEWyOkc,OjB3N{C1NlY9N2F-
Kasumi-1	NXHMSphLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M3GyZlczKGh?		M{jHTGlEPTB;MD6wNVYh\|ryP	Ml\HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3N{C1NlYoRjJyNUewOVI3RC:jPh?=
RS4-11	MlXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NEHL[\|Y4OiCq		NG\QXJZKSzVyPUGg{txO	NFLiSIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEW3NFUzPid-MkC1O\|A2OjZ:L3G+
THP1	MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NVTQTXNZPzJiaB?=		NVfqc5JLUUN3ME2wMlUh\|ryP	MlPEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3N{C1NlYoRjJyNUewOVI3RC:jPh?=
Kasumi-1	NEHBXpdHfW6ldHnvckBCe3OjeR?=				NYPlSG1QUW6qaXLpeIlwdiCxZjDjMWtqfCCjdYTvdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjBzNTFOwG0>	M{nwW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEOzNFM6Lz5{MEizN\|A{QTxxYU6=
A549	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M{GyUlE3KGh?		NGTie2VCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzz	NYeweGg4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ\|PD;hQi=>
HL60	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MVixOkBp		MX7BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKTE[wJINmdGy\|	Mm\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUC0OlMoRjJzNEWwOFY{RC:jPh?=
HUVEC	NWj4cWFiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NYTjO5dOOTZiaB?=		M4XSbGlvcGmkaYTpc44hd2ZiVlXHSk1qdmS3Y3XkJINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiMj63OUDPxE1?	MoX0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUC0OlMoRjJzNEWwOFY{RC:jPh?=
HUVEC	NYXEeYlXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NWraVYNGOTZiaB?=		M2j3NGlvcGmkaYTpc44hd2ZiYl\HSk1qdmS3Y3XkJINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiND6wOEDPxE1?	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR3MES2N{c,OjF2NUC0OlM9N2F-
IM9	MnLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NWPOOpRIOTZiaB?=		NUnZUYw3SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTW06KGOnbHzz	NXHEdpRPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ\|PD;hQi=>
K562	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MX6xOkBp		NEK3XmZCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzz	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR3MES2N{c,OjF2NUC0OlM9N2F-
MDA-MB-231	NGOwRYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NU\Qc45FOTZiaB?=		MU\BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{	M{HNRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEWwOFY{Lz5{MUS1NFQ3OzxxYU6=
H460	MmHLR5l1d3SxeHnjJGF{e2G7		M4HtUlczKGh?		NYPlNI04UUN3ME2yMlch\|ryP	M3L0cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkKxPFgxLz5{MU[yNVg5ODxxYU6=
SMMC7721	NGTKfWtEgXSxdH;4bYMhSXO\|YYm=		MmnvO\|IhcA>?		NIrZWpJKSzVyPU[uOFch\|ryP	MmXuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4MkG4PFAoRjJzNkKxPFgxRC:jPh?=
WI38	MVXDfZRwfG:6aXOgRZN{[Xl?		M{\wbFczKGh?		M3PzSGlEPTB;OD61OkDPxE1?	NYLPXGlQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2NlE5QDBpPkKxOlIyQDhyPD;hQi=>
HEK293	MoniT4lv[XOnIFHzd4F6	NVm3PI9YOTByIH7N	NYXwe4NtOSCq		MmO2[I9meyCwb4SgbY5pcWKrdDDWSWdHNWmwZIXj[YQh[XW2b4Doc5NxcG:{eXzheIlwdiCxZjD0fZJwe2mwZTCxNVc2KHKnc3nkeYUhd25iVlXHSnIzKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJM>	M2L4bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEi1Nlg4Lz5{MUi4OVI5PzxxYU6=
HUVEC	MYTGeY5kfGmxbjDBd5NigQ>?	MVmxJO69VQ>?	NYrkSGxrOjRiaB?=		MoOyRY51cWGwZ3nv[4VvcWNiYXP0bZZqfHliYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hXkWJRj3pcoR2[2WmIHPlcIwhdWmpcnH0bY9v	M{nJR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[zN\|A2Lz5{MUm2N\|MxPTxxYU6=
HUVEC	MnTySpVv[3Srb36gRZN{[Xl?	NXLFSG1vOSEQvF2=	M{LhT\|EhcA>?		MnW2TY5pcWKrdHnvckBw\iCHUlugdIhwe3Cqb4L5cIF1cW:wIHH0JHRpejJyMj;UfZIzODRiaX6gWmVITi2\|dHnteYxifGWmIFjVWmVE	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4M{OwOUc,OjF7NkOzNFU9N2F-
HUVEC	MYPGeY5kfGmxbjDBd5NigQ>?	M2nMWVEh\|ryP	M{DVcVEhcA>?		MnnUTY5pcWKrdHnvckBw\iCnTl;TJJBpd3OyaH;yfYxifGmxbjDheEBU\XJvMUG3NkBqdiCYRVfGMZN1cW23bHH0[YQhUFWYRVO=	MoPkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkOzNFUoRjJzOU[zN\|A2RC:jPh?=
HUVEC	NUPqVYdQU2mwYYPlJGF{e2G7	M4TP[lEh\|ryP	M{XnWlEhcA>?		Mmm3TY5pcWKrdHnvckBw\iCYRVfGVlIheGixc4Doc5J6dGG2aX;uJIF1KHS7cj2xNVc2KGmwIG\FS2Yue3SrbYXsZZRm\CCKVW\FRy=>	NWrFVGJ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlM{ODVpPkKxPVY{OzB3PD;hQi=>
HUVEC	MoC0SpVv[3Srb36gRZN{[Xl?	MnHTNUDPxE1?	NUDhdGVOOSCq		M{LLdoRw\XNibn;0JIlvcGmkaYSgRWtVKHCqb4PwbI9zgWyjdHnvckBifCCVZYKtOFc{KGmwIG\FS2Yue3SrbYXsZZRm\CCKVW\FRy=>	M1nZS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[zN\|A2Lz5{MUm2N\|MxPTxxYU6=
HL60	MUPDfZRwfG:6aXOgRZN{[Xl?	M2XkclUxKM7:TR?=	MXy0PEBp	MVvEUXNQ	M3HBO2lEPTB;MUWuOUDPxE1?	MlfiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMUmxPFgoRjJ{MEG5NVg5RC:jPh?=
K562	NWDYelZMS3m2b4TvfIlkKEG\|c3H5	MYq1NEDPxE1?	NIfCcGk1QCCq	MnP6SG1UVw>?	NWS1[mRuUUN3ME2yNU46KM7:TR?=	M2C2W\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEG5NVg5Lz5{MkCxPVE5QDxxYU6=
PC3	MnTSR5l1d3SxeHnjJGF{e2G7	MYK1NEDPxE1?	NWj4Z5duPDhiaB?=	NVrrVIhYTE2VTx?=	MmPSTWM2OD1{NT6xJO69VQ>?	NHzONVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCxPVE5QCd-MkKwNVkyQDh:L3G+
SF-539	MlLJT4lv[XOnIFHzd4F6	M13yVlM{OyEQvF2=	NIHsTJM3OCCvaX6=		MWfJcohq[mm2aX;uJI9nKFCGR1\SZoV1[SC2eYLvd4lv\SCtaX7hd4Uh[WO2aY\peJkhcW5iUFTHSk1DSi2\|dHnteYxifGWmIHj1cYFvKFOILUWzPUBk\WyuczD3bZRpKEmFNUCgc4YhOTJwMjFOwG0>	NFu2OHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKwOFc1OSd-MkKyNFQ4PDF:L3G+
HAEC	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4DweVExOCEQvF2=	NVe4e\|k4PzJiaB?=		NYPQVWJ5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIRWVEKGOnbHzzJIV5eHKnc4PpcochXkWJRmKge4l1cCCLQ{WwJI9nKDBwMTFOwG0>	MnPxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NES2O\|koRjJ{NES0Olc6RC:jPh?=
HT-29	MnWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX;GTHlrOTByIN88US=>	NEPNSGM4OiCq		M1i5NmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOg[ZhxemW\|c3nu[{BXTUeIUjD3bZRpKEmFNUCgc4YhOC5\|MzFOwG0>	NFvkcmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS0OFY4QSd-MkK0OFQ3Pzl:L3G+
MV4-11	NIDJ[WJEgXSxdH;4bYMhSXO\|YYm=		MojtO\|IhcA>?		NXnWWWxzUUN3ME2wMlAxOyEQvF2=	M2C4UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEWyOVE5Lz5{MkS1NlUyQDxxYU6=
HepG2	MVzDfZRwfG:6aXOgRZN{[Xl?		NFK1bYk1QCCq		NHT1c3RKSzVyPUGzMlI1KM7:TR?=	NX\ycWdQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFM3ODhpPkKyOFg{PjB6PD;hQi=>
PC9	MmfnR5l1d3SxeHnjJGF{e2G7		MX:0PEBp		MnKxTWM2OD1zMD65O{DPxE1?	NWLPenRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFM3ODhpPkKyOFg{PjB6PD;hQi=>
CAKI-1	M2GwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NY[wcZhLOTByIN88US=>	M17ucFQ5KGh?	MmrMSG1UVw>?	MkXYS2k2OD1yLk[zJO69VQ>?	NXjaOllzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OlA3OjdpPkKyOVYxPjJ5PD;hQi=>
EKVX	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEHYc\|UyODBizszN	MoXoOFghcA>?	MX\EUXNQ	MX7HTVUxRTdwOTFOwG0>	NHWxW2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
MCF7	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH7pfmcyODBizszN	MXu0PEBp	NH2z[W5FVVOR	MnLNS2k2OT1{IN88US=>	NI\wTlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
MDA-MB-435	M4jhUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mo[2NVAxKM7:TR?=	MnH4OFghcA>?	M{PmUGROW09?	MV7HTVUzRTJizszN	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
OVCAR3	NVy2TZhDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGDBbIIyODBizszN	NEjlNm01QCCq	M2XUPWROW09?	Mn7YS2k2Oz1\|LkKg{txO	M3zxU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NU[wOlI4Lz5{MkW2NFYzPzxxYU6=
SNB19	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWmxNFAh\|ryP	M{DrVFQ5KGh?	NGm5blRFVVOR	NIfF[JVIUTV2PUGwJO69VQ>?	NG\GZ3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
SW620	MnjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWf4OIZROTByIN88US=>	MUK0PEBp	Ml7TSG1UVw>?	NG\Od4NIUTV3PUGuN{DPxE1?	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
TK10	M3;TUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVuxNFAh\|ryP	NH[xfXM1QCCq	Ml;MSG1UVw>?	MmHUS2k2Pj14LkOg{txO	NELwUJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
UACC257	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYCxNFAh\|ryP	M3zMVlQ5KGh?	NVjxNIdkTE2VTx?=	MlLjS2k2Pz12IN88US=>	NXPlRVlCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OlA3OjdpPkKyOVYxPjJ5PD;hQi=>
HAEC	NXv5NVVDS3m2b4TvfIlkKEG\|c3H5	MUexNFAh\|ryP	MVO3NkBp	NVWzc4dtTE2VTx?=	M3nFTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KF[HR1\SJIV5eHKnc4PpcochUEGHQzD3bZRpKEmFNUCgc4YhOC5zIN88US=>	M4j2NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUOxOVQyLz5{M{GzNVU1OTxxYU6=
HT-29	MnvnR5l1d3SxeHnjJGF{e2G7	NXe3N2lbOTByIN88US=>	MXi3NkBp	NV[3Zo1DTE2VTx?=	NFr6SIZEgXSxdH;4bYNqfHliYXfhbY5{fCCYRVfGVkBmgHC{ZYPzbY5oKGi3bXHuJGhVNTJ7IHPlcIx{KHerdHigTWM2OCCxZjCwMlM{KM7:TR?=	NUjrcZpkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxN\|E2PDFpPkKzNVMyPTRzPD;hQi=>
HCT116	Mle5SpVv[3Srb36gRZN{[Xl?		NGnCfmEzPCCq	Moi2SG1UVw>?	MmrDRY51cW2rZ4LheI9zgSCjY4Tpeol1gSCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygcYloemG2aX;u	NG[0S4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G1N\|IxOCd-MkOxOVMzODB:L3G+
HUVEC	NH3FS3ZHfW6ldHnvckBCe3OjeR?=	NEDHXHozKM7:TR?=	NUjLT\|RVOThiaB?=	NYjy[GFTTE2VTx?=	M{[0fmFvfGmjbnfpc4dmdmmlIHHjeIl3cXS7IHnuJGhWXkWFczD1coRmeiCqeYDvfIlkKGOxbnTpeIlwdiCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHS3YnWg[o9zdWG2aX;u	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF3M{KwNEc,OjNzNUOyNFA9N2F-
ACHN	NEf6eWpEgXSxdH;4bYMhSXO\|YYm=		MXe2JIQ>		MU\JR\|UxRTJwNTFOwG0>	NWnYT3h5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzOlAyODRpPkKzN\|YxOTB2PD;hQi=>
A498	M4n2TmN6fG:2b4jpZ{BCe3OjeR?=	MVOxNFAh\|ryP	MWq3NkBp	MUPEUXNQ	M2rJPGlEPTB;ND6zJO69VQ>?	NY[wTVBLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PFk3OjZpPkKzOFg6PjJ4PD;hQi=>
HUVEC	M1vhd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnfnN{DPxE1?	MWSyOEBp	MkH3SG1UVw>?	MUDBcpRq[W6paX;n[Y5q[yCjY4Tpeol1gSCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKF[HR1[tbY5lfWOnZDD0eYJmKG[xcn3heIlwdiC5aYToJGVEPTBib3[gNE43PDVizszN	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV6M{mxNUc,OjN3OEO5NVE9N2F-
HUVEC	NWnOVllDU2mwYYPlJGF{e2G7	MoL4NlAxKM7:TR?=		NGfOZoRFVVOR	M1nOUWlvcGmkaYTpc44hd2ZiVlXHSnIzKHCqb4PwbI9zgWyjdHnvckBqdiCpcn;3eIgh\mGldH;yMZN1cW23bHH0[YQhUFWYRVO=	Mm[5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3OEO5NVEoRjJ\|NUizPVEyRC:jPh?=
HUVEC	NHm4W4tMcW6jc3WgRZN{[Xl?	NWnYcVlDOjByIN88US=>		MoXGSG1UVw>?	MYTJcohq[mm2aX;uJI9nKF[HR1\SNUBxcG:\|cHjvdplt[XSrb36gbY4h\3Kxd4ToJIZi[3Sxcj3zeIlufWyjdHXkJGhWXkWF	MnfJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3OEO5NVEoRjJ\|NUizPVEyRC:jPh?=
A549	NEPjb2NEgXSxdH;4bYMhSXO\|YYm=		NYfoPGprPzJiaB?=	NYTYNHBOTE2VTx?=	NGjq[3hKSzVyPUKuOFQh\|ryP	NV\JdnNvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NFI1PDFpPkKzOlAzPDRzPD;hQi=>
HCT116	NIrI[mREgXSxdH;4bYMhSXO\|YYm=		NXLUNWFyPzJiaB?=	NGj2TolFVVOR	NUnBb\|ZMUUN3ME20MlcyKM7:TR?=	NInxUXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNlQ1OSd-MkO2NFI1PDF:L3G+
MCF7	MmHFR5l1d3SxeHnjJGF{e2G7		M1KyflczKGh?	NHTmXJdFVVOR	MWDJR\|UxRTZwMkmg{txO	M321[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkCyOFQyLz5{M{[wNlQ1OTxxYU6=
BGC	MkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NFHh[Fg4OiCq	NF[0dY9FVVOR	NVzy[3RZUUN3ME20Mlc5KM7:TR?=	NGHJe\|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1OCd-MkO5PVkxPDB:L3G+
BxPC3	NYTWUoI3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NYXlc4o3PzJiaB?=	MV;EUXNQ	NG\Xd5RKSzVyPUOuOlMh\|ryP	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl7OUC0NEc,OjN7OUmwOFA9N2F-
HT-29	NFH5bHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MXK3NkBp	MV;EUXNQ	M1f1eGlEPTB;MT60O{DPxE1?	NFztTY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1OCd-MkO5PVkxPDB:L3G+
T24	NX;aZldKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MUm3NkBp	NHv3VZZFVVOR	MWHJR\|UxRTJwNESg{txO	NYn3SWNSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDBpPkKzPVk6ODRyPD;hQi=>
4T1	MmPzR5l1d3SxeHnjJGF{e2G7		MWm3NkBp	MVfEUXNQ	NI\LVHdKSzVyPUCuNFE3KM7:TR?=	NIrBU3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MCF7	MlK3R5l1d3SxeHnjJGF{e2G7		M3fYN\|czKGh?	M3Px[2ROW09?	MlTiTWM2OD1yLkCyO\|Eh\|ryP	NFnhfZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MCF7	NHTrWotEgXSxdH;4bYMhSXO\|YYm=		MWG3NkBp	MYHEUXNQ	M37TZ2lEPTB;MD6wNlk{KM7:TR?=	MkD6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
MDA-MB-231	MULDfZRwfG:6aXOgRZN{[Xl?		NH3je5k4OiCq	NU[4ZnB6TE2VTx?=	MVfJR\|UxRTBwMEKyN{DPxE1?	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7ME[1Nkc,OjR6OUC2OVI9N2F-
MDA-MB-435	NYPaWXlqS3m2b4TvfIlkKEG\|c3H5		MoHwO\|IhcA>?	M{L5RmROW09?	NXiwVZNpUUN3ME2wMlAxQTdizszN	NU\JZnBDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PVA3PTJpPkK0PFkxPjV{PD;hQi=>
MDA-MB-468	NY\Nbno1S3m2b4TvfIlkKEG\|c3H5		Ml\2O\|IhcA>?	NIXleoNFVVOR	NFrM[mxKSzVyPUCuNFA3OSEQvF2=	NFLTW4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
A431	NIPj[JBMcW6jc3WgRZN{[Xl?	MVWxNEDPxE1?	MmLzNUBp	MljxSG1UVw>?	NV3TOmxMUW6qaXLpeIlwdiCxZjDFS2ZTKHerdHigTWM2OCCxZjCwMlE4OjFizszN	NIW3Zlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
SH-SY5Y	NXLjUYN2U2mwYYPlJGF{e2G7	NXG5UpQ{OTBizszN	NXTwc45nOSCq	M4jpe2ROW09?	M3\rO2lvcGmkaYTpc44hd2ZiUFTHSnJj\XSjIIfpeIghUUN3MDDv[kAxNjB6M{Gg{txO	NU\6W5BFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PVA3PTJpPkK0PFkxPjV{PD;hQi=>
U251	MlTPT4lv[XOnIFHzd4F6	NHKzbWkyOCEQvF2=	M3q3d\|EhcA>?	MmHYSG1UVw>?	MVjJcohq[mm2aX;uJI9nKF[HR1\SNkB4cXSqIFnDOVAhd2ZiMD6wNVg6KM7:TR?=	M1LTSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
Bel7402	MoHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NHXQOVI4OiCq	MYHEUXNQ	NHnxU5VKSzVyPUKuOlch\|ryP	MkTzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MES5OlEoRjJ2OUC0PVYyRC:jPh?=
HK2	NWe4c5VxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M33vcFczKGh?	MYHEUXNQ	NVK1WWpiUUN3ME21Mlg2KM7:TR?=	M3zIWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
LO2	M3XoXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M{C2VVczKGh?	M{m1OmROW09?	MYLJR\|UxRTF7LkmzJO69VQ>?	Mn3rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MES5OlEoRjJ2OUC0PVYyRC:jPh?=
MV4-11	NUmwT\|lvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MofTOFghcA>?	NV3Vc4VkTE2VTx?=	M3S1XWlEPTB;MD6wNFMh\|ryP	NXLWUG5pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFQ6PjFpPkK0PVA1QTZzPD;hQi=>
NCI-H3122	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MkC3O\|IhcA>?	MXfEUXNQ	NWTIOWk3UUN3ME2wMlg{KM7:TR?=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2NUc,OjR7MES5OlE9N2F-
NCI-H460	NWDkXXBUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NYfINI86PzJiaB?=	MY\EUXNQ	NGPrN4lKSzVyPUSuN\|Eh\|ryP	M3TYbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
NCI-H526	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MoDMO\|IhcA>?	NVrQVFZDTE2VTx?=	M1jqVGlEPTB;MT6wNUDPxE1?	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2NUc,OjR7MES5OlE9N2F-
TT	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NXz0XXlPPzJiaB?=	MoHISG1UVw>?	MlHUTWM2OD1yLkC0JO69VQ>?	NXLxcIVpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFQ6PjFpPkK0PVA1QTZzPD;hQi=>
3T3	NIrKS2NCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MmjzO\|IhcHK\|		NU\lNnFrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTCzWFMh[2WubIOg[ZhxemW\|c3nu[{BpfW2jbjDDV2YyWiCjZoTldkA4OiCqcoOgZpkhS2WubITpeIVzKGG\|c3H5MEBC[3Srdnn0fUA:KDBwMEmg{txONg>?	NVfORpo2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2PVQ3PDFpPkG4Olk1PjRzPD;hQi=>
MV4-11	NG\U[VBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MlPHO\|IhcHK\|		MnPWRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPVkStNVEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFA1OyEQvF2u	NVrDU5YxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OVQyQTlpPkG5O\|U1OTl7PD;hQi=>
HEK293	NUj3Vo1NTnWwY4Tpc44h[XO\|YYm=				MV\CbY5lcW6pIHHm[olvcXS7IITvJGZNXDNiY3H0ZYx6fGmlIHTvcYFqdiCneIDy[ZN{\WRiaX6gTGVMOjl\|IHPlcIx{KGK7IHPvcZBmfGm2aY\lJIJqdmSrbnegZZN{[XluIFvkJF0hOC5yMEC0O{DPxE1w	MnS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5NUSxPVkoRjF7N{W0NVk6RC:jPh?=
FDC-P1	Mo\pSpVv[3Srb36gZZN{[Xl?		NFfvZlY1QCCqcoO=		MWPJcohq[mm2aX;uJI9nKGi3bXHuJGZOWyCneIDy[ZN{\WRiaX6g[5Jwf3SqIH\hZ5RweiCmZYDlcoRmdnRibX;1d4UhTkSFLWCxJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiRl3TMY1m\GmjdHXkJINmdGxicILvcIln\XKjdHnvckBqdiCycnXz[Y5k\SCqdX3hckBEW0ZzIHHmeIVzKDR6IHjyd{BjgSC{ZYPhfpVzcW5iZInlJJJm\HWldHnvckBie3OjeTygTWM2OCB;IECuNVU2KM7:TT6=	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF3Nk[4PUc,OjBzNU[2PFk9N2F-
primary leukemia cells	MXXDfZRwfG:6aXPpeJkh[XO\|YYm=		Ml32O\|IhcHK\|		NV\jfXF2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4heHKrbXHyfUBt\XWtZX3pZUBk\WyuczDpd49t[XSnZDDmdo9uKGGldYTlJI16\WyxaXSgcIV2c2WvaXGgdIF1cWWwdDDlfJBz\XO\|aX7nJGZNXDNvSWTEJI12fGG2aX;uJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDseYNq\mW{YYPlJIF{e2G7LDDJR\|UxKD1iMD6wN{DPxE1w	NWXTOI96RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlEzODFpPkKyNlIyOjBzPD;hQi=>
primary leukemia cells	M{fIUmN6fG:2b4jpZ4l1gSCjc4PhfS=>		M4j1RlczKGi{cx?=		M2nJVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJBzcW2jcomgcIV2c2WvaXGgZ4VtdHNiaYPvcIF1\WRiZoLvcUBi[3W2ZTDtfYVtd2mmIHzleYtmdWmjIIDheIlmdnRiZYjwdoV{e2mwZzD3bYxlKHS7cHWgSmxVOyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhUUN3MDC9JFAvODNizszNMi=>	M2W4fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkKxNlAyLz5{MkKyNVIxOTxxYU6=
primary leukemia cells	Mm\PR5l1d3SxeHnjbZR6KGG\|c3H5		M1PKXlczKGi{cx?=		MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwdolu[XK7IHzleYtmdWmjIHPlcIx{KGm\|b3zheIVlKG[{b32gZYN2fGVibYnlcI9q\CCuZYXr[Y1q[SCyYYTp[Y51KGW6cILld5NqdmdiRlzUN{1FQDN3WTDteZRifGmxbjDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nlibIXjbYZmemG\|ZTDhd5NigSxiSVO1NEA:KDFwMTFOwG0v	M{Gyb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkKxNlAyLz5{MkKyNVIxOTxxYU6=
endothelial precursor cells	NFr5eYFHfW6ldHnvckBie3OjeR?=				MkX3TY5pcWKrdHnvckBw\iCnbnTveIhmdGmjbDDjc5JlKGG{ZXGg[o9zdWG2aX;uJIlvKGWwZH;0bIVtcWGuIIDy[YN2enOxcjDj[YxteyCkeTDDSFMyKGOxcnSgZZJm[SCmZYTlZ5Rqd25iYnHz[YQheGinbn;0fZBq[yCmcoXnJIRqe2OxdnXyfUBj[XOnZDDhd5NigSxiSVO1NEA:KDBwMEC5OkDPxE1w	NVn0eJJ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0NFk3PjZpPkKyOFA6PjZ4PD;hQi=>
endothelial precursor cells	MnzHSpVv[3Srb36gZZN{[Xl?				MVvJcohq[mm2aX;uJI9nKGOnbHygcYloemG2aX;uJIlvKGWwZH;0bIVtcWGuIIDy[YN2enOxcjDj[YxteyCkeTDPdol{KGOnbHygcYloemG2aX;uJItqfCCkYYPl[EBxcGWwb4T5dIlkKGS{dXeg[Il{[2:4ZYL5JIJie2WmIHHzd4F6NCCLQ{WwJF0hOTNwNjFOwG0v	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjRyOU[2Okc,OjJ2MEm2OlY9N2F-
U251	NUTwW2ZSTnWwY4Tpc44h[XO\|YYm=		NWr3ZXJYPjBibXnudy=>		NV3HclFzUW6qaXLpeIlwdiCxZjDWSWdHWjJiaX6gbJVu[W5iVUK1NUBk\WyuczDwdoV1emWjdHXkJIZweiB4MDDtbY5{KG2nYYP1doVlKGGodHXyJFEhcHJiYomgSWxKW0FuIFnDOVAhRSBzOD65JO69VS5?	M3robVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{O5NFkxLz5{MkezPVA6ODxxYU6=
U251	M1rpVGZ2dmO2aX;uJIF{e2G7		M2DxNFYxKG2rboO=		MnTrTY5pcWKrdHnvckBw\iCYRVfGMYlv\HWlZXSgWmVITlJ{IIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCXMkWxJINmdGy\|IH;2[ZJmgHC{ZYPzbY5oKE[uaz2xJJBz\XS{ZXH0[YQh\m:{IE[wJI1qdnNicILpc5IhfG9iVlXHSkBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjCxNEBucW6\|IHL5JJBpd3OyaH;0fZJwe2mwZTDFUGlUSSCleYTvZoxwfCCjbnHsfZNqeyxiSVO1NEA:KDF6Lkmg{txONg>?	M2PWNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{e1NFkxLz5{M{O3OVA6ODxxYU6=
U251	NX;XbGZyTnWwY4Tpc44h[XO\|YYm=		Mlr0OlAhdWmwcx?=		M3PrW2lvcGmkaYTpc44hd2ZiVlXHSnIzKGmwIHj1cYFvKFV{NUGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCYRVfGMYlv\HWlZXSgeJlzd3OrbnWgdIhwe3Cqb4L5cIF1cW:wIHnuZ5Vj[XSnZDDmc5IhPjBibXnud{BxemmxcjD0c{BXTUeILXHjeIl3[XSrb36gcYVie3W{ZXSgNVAhdWmwczDifUBGVEmVQTygTWM2OCB;IEG4Mlkh\|ryPLh?=	M13i[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEO0NVM6Lz5{M{SzOFE{QTxxYU6=
CHO	NWru[ZVFTnWwY4Tpc44h[XO\|YYm=				NXfWdGhkUW6qaXLpeIlwdiCxZjDDZZYyNjJiY4XydoVvfCCvZXHzeZJm\CC3c3nu[{BSWGG2Y3igZZV1d22jdHnjJJBifGhiY3zhcZAhe3m\|dHXtJIlvKEOKTzDj[YxteyCneIDy[ZN{cW6pIFPhelEvOixiYnX0ZU0zKGGwZDDhcJBp[S1{L3TlcJRiNTFic4XieY5qfHNuIFnDOVAhRSB\|Mz60JO69VS5?	NUTocYZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVI2ODNpPkKzPFEzPTB\|PD;hQi=>
U251	NVL4WYVmTnWwY4Tpc44h[XO\|YYm=				NGq2To5KdmirYnn0bY9vKG:oIG\FS2ZTOiCrbjDoeY1idiCXMkWxJINmdGy\|IHL5JJBpd3OyaH;0fZJwe2mwZTDFUGlUSSxiSVO1NEA:KDBwMEG4PUDPxE1w	NXjEOWtlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA5PjVpPkK0PVAxQDZ3PD;hQi=>
MCF7	NU\ObGxkSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NEf3Zog1QCCqcoO=		MkjlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPQ1[3JINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD61JO69VS5?	MkLyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyNkSzOFcoRjJ3ME[0N\|Q4RC:jPh?=
HepG2	M1jmOmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MXu0PEBpenN?		NHfOOVFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCxN{43KM7:TT6=	NUfPXYhERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwOlQ{PDdpPkK1NFY1OzR5PD;hQi=>
CHO	NEjST4VHfW6ldHnvckBie3OjeR?=				Mo\YTY5pcWKrdHnvckBw\iC{YYDp[EBl\WyjeXXkJIlvf2G{ZDDy[YN1cW[7aX7nJJBwfGG\|c3n1cUBkfXK{ZX70JEhKU3JrIHnuJGNpcW6nc3WgbIFue3SncjDveoFzgSBqQ1jPLUBk\WyuczDzeIFjdGViZYjwdoV{e2mwZzDoSXJIKG2nYYP1doVlKHW\|aX7nJGlwdlexcnvzJGJienKjY4XkZUBifXSxbXH0[YQheGG2Y3igZ4xidXBicHzheIZwem1uIFnDOVAhRSB5Lkm0N\|I5KM7:TT6=	NYDreWZNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPFc4PTNpPkK1NFg4PzV\|PD;hQi=>
CHO K1	MXvGeY5kfGmxbjDhd5NigQ>?				NWnpUZdbUW6qaXLpeIlwdiCxZjDyZZBq\CCmZXzhfYVlKGmwd3Hy[EBz\WO2aX\5bY5oKHCxdHHzd4l2dSCldYLy[Y51KCiLS4KpJIlvKEOqaX7ld4UhcGGvc4TldkBwfmG{eTCoR2hQMSCNMTDj[YxteyC\|dHHicJkh\XiycnXzd4lv\yCqRWLHJI1m[XO3cnXkJJV{cW6pIFnvcndwemu\|IGH1ZZR1em9iYYX0c41ifGWmIIDheINpKGOuYX3wJJBt[XSob4LtMEBKSzVyIE2gNVAh\|ryPLh?=	NHruRnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4O\|c2Oyd-MkWwPFc4PTN:L3G+
CHO K1	MmnmSpVv[3Srb36gZZN{[Xl?				NUm1TFlOUW6qaXLpeIlwdiCxZjDmZZN1KHOxZHn1cUBkfXK{ZX70JEhKVmFrIHnuJGNpcW6nc3WgTIFue3SncjDPeoFzgSBqQ1jPLUBMOSClZXzsd{B1emGwc3\lZ5Rm\CC5aYToJIh2dWGwIF7helEvPSCvZXHzeZJm\CC3c3nu[{BKd26Zb4Lrd{BSfWG2dILvJIF2fG:vYYTl[EBx[XSlaDDjcIFueCCybHH0[o9zdSxiSVO1NEA:KDF3Lki0PFkh\|ryPLh?=	M4Pvc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEi3O\|U{Lz5{NUC4O\|c2OzxxYU6=
HEK293	Ml3tSpVv[3Srb36gZZN{[Xl?				NWHXR29ZUW6qaXLpeIlwdiCxZjDmZZN1KHOxZHn1cUBkfXK{ZX70JEhKVmFrIHnuJGhGUzJ7MzDj[YxteyC2cnHud4Zm[3SnZDD3bZRpKGi3bXHuJG5ifjFwNTDt[YF{fXKnZDD1d4lv\yCLb37Xc5JseyCTdXH0eJJwKGG3dH;tZZRm\CCyYYTjbEBkdGGvcDDwcIF1\m:{bTygTWM2OCB;IEO5MlgyODdizszNMi=>	MnPhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEe3OVMoRjJ3MEi3O\|U{RC:jPh?=
MOLM13	MoPlR5l1d3SxeHnjbZR6KGG\|c3H5		NYPk[YVPPDhiaILz		NGPzU3NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOV0yPMUOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMEG3O{DPxE1w	MmX2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEm4NVAoRjJ3MEi5PFExRC:jPh?=
MV4-11	MonSR5l1d3SxeHnjbZR6KGG\|c3H5		Mn;FOFghcHK\|		MnXrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUXY1NTFzIHPlcIx{KGG\|c3Xzd4VlKGG\|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB{NEOg{txONg>?	NIjEPIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4PVgyOCd-MkWwPFk5OTB:L3G+
HL60	MYXDfZRwfG:6aXPpeJkh[XO\|YYm=		M3LGb\|Q5KGi{cx?=		M4Xab2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNPjBiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODN4ODFOwG0v	M1[3W\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEi5PFExLz5{NUC4PVgyODxxYU6=
THP1	M1vGSGN6fG:2b4jpZ4l1gSCjc4PhfS=>		MnXkOFghcHK\|		NUnTcI1lS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXEiSMTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yNEW3JO69VS5?	NGX1b\|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4PVgyOCd-MkWwPFk5OTB:L3G+
ACHN	NIL6WJVEgXSxdH;4bYNqfHliYYPzZZk>		MnexO\|IhcHK\|		NGD1[JJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCS0iQIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzKM7:TT6=	NH3jbFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUGyOFEyPCd-MkWxNlQyOTR:L3G+
U251	M1XUbGZ2dmO2aX;uJIF{e2G7		MnKzOlAhdWmw		NG\yTndKdmirYnn0bY9vKG:oIG\FS2ZTOiCrbjDoeY1idiCXMkWxJINmdGy\|IHPvcZBwfW6mIIDy[ZRz\WG2ZXSg[o9zKDZyIH3pckBj\W[xcnWgWmVITiC\|dHnteYxifGmxbjDmc5IhOTBibXnud{BjgSCyaH;zdIhwfHm{b4PpcoUhTUyLU1GgZ5l1d2Kub4SgcYV1cG:mLDDJR\|UxKD1iMD6wNVg6KM7:TT6=	NFrqb\|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4NlUyQSd-MkW4PFI2OTl:L3G+
U251	M{e5WWZ2dmO2aX;uJIF{e2G7		NIDvO4I3OCCvaX6=		MY\Jcohq[mm2aX;uJI9nKFCGR1\SMYJmfGFiaX6gbJVu[W5iVUK1NUBk\WyuczDjc41xd3WwZDDwdoV1emWjdHXkJIZweiB4MDDtbY4h[mWob4LlJHBFT0ZvQlKgd5RqdXWuYYTpc44h\m:{IEGwJI1qdnNiYomgdIhwe3Cqb4T5do9{cW6nIFXMTXNCKGO7dH;icI91KG2ndHjv[EwhUUN3MDC9JFAvODh\|MTFOwG0v	NIPPb5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4NlUyQSd-MkW4PFI2OTl:L3G+
A431	M3XCTWZ2dmO2aX;uJIF{e2G7		NXPteFFuPjBibXnu		Mn7XTY5pcWKrdHnvckBw\iCHR1\SJIlvKGi3bXHuJGE1OzFiY3XscJMh[2:vcH;1coQheHKndILlZZRm\CCob4KgOlAhdWmwIHLl[o9z\SCHR1[gd5RqdXWuYYTpc44h\m:{IEGwJI1qdnNiYomgdIhwe3Cqb4T5do9{cW6nIFXMTXNCKGO7dH;icI91KG2ndHjv[EwhUUN3MDC9JFAvOTd{MTFOwG0v	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh6MkWxPUc,OjV6OEK1NVk9N2F-
HT-29	NH\zRmxEgXSxdH;4bYNqfHliYYPzZZk>		NITO[lQ1QCCqcoO=		NWrNfWxjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG\|c3H5MEBKSzVyIE2gOE44KM7:TT6=	NGLiVY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwPVE3PCd-Mk[wNFkyPjR:L3G+
A549	MUDDfZRwfG:6aXPpeJkh[XO\|YYm=		MYm0PEBpenN?		M4TTO2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR\|UxKD1iNz65N{DPxE1w	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByOUG2OEc,OjZyMEmxOlQ9N2F-
SKOV3	NHHEOXhEgXSxdH;4bYNqfHliYYPzZZk>		M3zCS\|Q5KGi{cx?=		NULIVmlsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG\|c3H5MEBKSzVyIE2gPU4zOSEQvF2u	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByOUG2OEc,OjZyMEmxOlQ9N2F-
PANC1	MUTDfZRwfG:6aXPpeJkh[XO\|YYm=		MWW0PEBpenN?		Mn7RR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGFPSzFiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR\|UxKD1iMUSuPVQh\|ryPLh?=	NG\NUYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwPVE3PCd-Mk[wNFkyPjR:L3G+
HepG2	NYXWd4JPS3m2b4TvfIlkcXS7IHHzd4F6		NXTPb3NHPDhiaILz		MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSBzNj6wOkDPxE1w	Mn30QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEmxOlQoRjJ4MEC5NVY1RC:jPh?=
MCF7	MYHDfZRwfG:6aXPpeJkh[XO\|YYm=		M37NeFQ5KGi{cx?=		MljnR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSB{NT60NUDPxE1w	Mn\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEmxOlQoRjJ4MEC5NVY1RC:jPh?=
Bel7402	M2rCTnBpd3SxY4n0c5RwgGmlaYT5JIF{e2G7		NFnQN442KGi{cx?=		NIHqXm9RcG:2b3P5eI91d3irY3n0fUBi\2GrboP0JIh2dWGwIFLlcFc1ODJiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkheHKnaX7jeYJifGWmIH\vdkA2KGi{czD3bZRpKGOnbHzzJIZwdGyxd3XkJIJ6KFWYQT2xJIlzemGmaXH0bY9vKGG2IEOuNEBuXy:lbTeyJIZweiB{MDDtbY5{KG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBES0t6IHHzd4F6NCCHQ{WwJF0hOTFizszNMi=>	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV6NEC4OUc,OjZ3OESwPFU9N2F-
PANC1	M17FTHBpd3SxY4n0c5RwgGmlaYT5JIF{e2G7		NVnE[WhEPSCqcoO=		M4Xt[3Bpd3SxY4n0c5RwgGmlaYT5JIFo[Wmwc4SgbJVu[W5iUFHOR\|Eh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgdJJmcW6ldXLheIVlKG[xcjC1JIhzeyC5aYToJINmdGy\|IH\vcIxwf2WmIHL5JHVXSS1zIHnydoFlcWG2aX;uJIF1KDNwMDDtW{9kdSd{IH\vdkAzOCCvaX7zJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDDR2s5KGG\|c3H5MEBGSzVyIE2gNVMh\|ryPLh?=	M2iySFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUi0NFg2Lz5{NkW4OFA5PTxxYU6=
SVEC4-10	MYTDfZRwfG:6aXPpeJkh[XO\|YYm=		M1;ve\|I1KGi{cx?=		NVi0NY46S3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhW1[HQ{StNVAh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IEig{txONg>?	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjlzMkGxNUc,OjZ7MUKxNVE9N2F-
HUVEC	M1PpUGFvfGmjbnfpc4dmdmmlIHHzd4F6	MmP5NVAhfU1?	NU\qcWZiPSCqcoO=		NX7pfmtVSW62aXHu[4lw\2WwaXOgZYN1cX[rdImgbY4hcHWvYX6gTHVXTUNiY3XscJMh[XO\|ZYPz[YQh[XNiYX7nbY9o\W6nc3nzJJJifGViYYSgNVAhfU1iYX\0[ZIhPSCqcoOgZpkh\W6mb4To[Yxq[WxidIXi[UBnd3KvYYTpc44h[XO\|YYmgdoVt[XSrdnWgeI8h[2:wdILvcC=>	NYDFfXBKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5NVIyOTFpPkK2PVEzOTFzPD;hQi=>
HT-29	MVnDfZRwfG:6aXPpeJkh[XO\|YYm=				MmPqR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMT63JO69VS5?	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{MEiwNEc,OjZ7MkC4NFA9N2F-
A549	MnrIR5l1d3SxeHnjbZR6KGG\|c3H5				M17rN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iOT6xJO69VS5?	Ml\BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7MkC4NFAoRjJ4OUKwPFAxRC:jPh?=
MDA-MB-435	MkjlR5l1d3SxeHnjbZR6KGG\|c3H5				Mne4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUSzOUBk\WyuczDifUBOXFRiYYPzZZktKEmFNUCgQUA6NjNizszNMi=>	MoDuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7MkC4NFAoRjJ4OUKwPFAxRC:jPh?=
MV4-11	MWXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MorpO\|IhcHK\|		NIPTTpFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGZNXDNvSWTEJIRmeGWwZHXueEBpfW2jbjDNWlQuOTFiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUCgQUAxNjByMTFOwG0v	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
HL60	M13VTWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MlizO\|IhcHK\|		NW[xeVJFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubz;DR2s5KGG\|c3H5MEBIUTVyIE2gNE4xODFizszNMi=>	MmnzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
BAF3	M2LNRWZ2dmO2aX;uJIF{e2G7		MkP1O\|IhcHK\|		NHfwfVZKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjT2lVKFR4N{DJJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCCycn;sbYZmemG2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwN0OFS{igZZN{[XluIFfJOVAhRSByLkCwNkDPxE1w	Ml\FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
MOLM14	M1u5NGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NVPLfVNyPzJiaILz		M4f1OWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgSmxVOy2LVFSg[IVx\W6mZX70JIh2dWGwIF3PUG0yPCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFAvODB3IN88UU4>	M3vU[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
BAF3	MoLBSpVv[3Srb36gZZN{[Xl?		MoTQO\|IhcHK\|		M1[zV2lvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhXjV3OVSvWlY2PEFiZH;1ZoxmKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCwMlAxPiEQvF2u	NETGXlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BAF3	NVvxNIU{TnWwY4Tpc44h[XO\|YYm=		NHfhTYo4OiCqcoO=		Mk\2TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBXPTV7RDDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5yMEmg{txONg>?	NX\xS3RvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
BAF3	M{K5R2Z2dmO2aX;uJIF{e2G7		M{nFdFczKGi{cx?=		MnPlTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBXPjV2QTDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5yMjFOwG0v	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BAF3	NIWwXo9HfW6ldHnvckBie3OjeR?=		NXW2dlEzPzJiaILz		NU\ncWRKUW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgZ2tKXCCONU[3VEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNlMh\|ryPLh?=	NIrtUXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
GISTT1	NFnET\|VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NF;VOI44OiCqcoO=		MnTHRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDjT2lVKGSncHXu[IVvfCCqdX3hckBIUVOWVEGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwN0OFS{igZZN{[XluIFfJOVAhRSByLkC0NUDPxE1w	NIfwVFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BAF3	M1zHcmZ2dmO2aX;uJIF{e2G7		NHzXZXI4OiCqcoO=		NXn3PVBRUW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgZ2tKXCCWNkewTU9XPTV7RDDkc5VjdGVibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFAvODV\|IN88UU4>	MnjpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
BAF3	MkDySpVv[3Srb36gZZN{[Xl?		MojlO\|IhcHK\|		MnH0TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCwMlA4QCEQvF2u	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
GIST882	NYTRTmtuSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M4L0d\|czKGi{cx?=		M1jMWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgZ2tKXCCmZYDlcoRmdnRiaIXtZY4hT0mVVEi4NkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNVEh\|ryPLh?=	NXXrOGRQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
BAF3	M{LyXmZ2dmO2aX;uJIF{e2G7		NIDw[FM4OiCqcoO=		M4XVNmlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhVjh{MlugcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8wS0ONODDhd5NigSxiR1m1NEA:KDBwNUGg{txONg>?	NY\qVXZxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
Rec1	MX;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MlfSO\|IhcHK\|		MkLoRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCUZXOxJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD64O{DPxE1w	NXPhTFVmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
K562	NIL2VnRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MkX6O\|IhcHK\|		NXexfGhkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMJIRmeGWwZHXueEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubz;DR2s5KGG\|c3H5MEBIUTVyIE2gNUDPxE1w	NFr1W5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
KU812	NWrB[lFoSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MlixO\|IhcHK\|		NWjvXolDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMJIRmeGWwZHXueEBpfW2jbjDLWVgyOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFEvOSEQvF2u	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BCR-ABL dependent MEG01	NX;USG82SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NYTWcnNUPzJiaILz		MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKFUj3BRmwh\GWyZX7k[Y51KE2HR{CxJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMT6yJO69VS5?	MmHuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
BAF3	MX\GeY5kfGmxbjDhd5NigQ>?		M2LHclczKGi{cx?=		MV3Jcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJGQ5OT[YIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUCgQUAyNjN6IN88UU4>	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
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RWPE1	NX3wdlF[S3m2b4TvfIlkcXS7IHHzd4F6		M3;xTVQ5KGi{cx?=		Mli4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVndRTTFiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI{KM7:TT6=	M3ra[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVc{Lz5{N{GyPFE4OzxxYU6=
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MDA-MB-231	Ml7vR5l1d3SxeHnjbZR6KGG\|c3H5		NFP1SHM1QCCqcoO=		NEHUXWZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPy52NDFOwG0v	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR2OEmxOkc,Ojd2NEi5NVY9N2F-
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BT549	NWX5O4FPS3m2b4TvfIlkcXS7IHHzd4F6		MmHtOFghcHK\|		M4G4OWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJVPTR7IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMUWuOVQh\|ryPLh?=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR2OEmxOkc,Ojd2NEi5NVY9N2F-
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DU145	MnLNR5l1d3SxeHnjbZR6KGG\|c3H5		NVThVnVjPDhiaILz		NUDxUmRCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTZwMzFOwG0v	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ\|OUO2PUc,Ojd4M{mzOlk9N2F-
RWPE1	M3TidWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NWrvbZRnPDhiaILz		NWnkSpZ1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWleSRUGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjVwMjFOwG0v	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ\|OUO2PUc,Ojd4M{mzOlk9N2F-
L02	MUTDfZRwfG:6aXPpeJkh[XO\|YYm=		M3HsRlczKGi{cx?=		MoS2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUFAzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFQvPjJizszNMi=>	NI\VNnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[0N\|Y{QSd-Mke2OFM3Ozl:L3G+
HL60	M3fMcmN6fG:2b4jpZ4l1gSCjc4PhfS=>		M{DvNFczKGi{cx?=		MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFQvQTVizszNMi=>	NEToNGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[0N\|Y{QSd-Mke2OFM3Ozl:L3G+
U251	M{DYOmZ2dmO2aX;uJIF{e2G7		Ml7YOlAhdWmwcx?=		NXXBR21HUW6qaXLpeIlwdiCxZjDWSWdHWi1{IHnuJIh2dWGwIGWyOVEh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIG\FS2YhcW6mdXPl[EBxcG:\|cHjvdplt[XSrb36gdJJmcW6ldXLheIVlKG[xcjC2NEBucW6\|IH\vcIxwf2WmIHL5JHZGT0ZiYXTkbZRqd25ibXXhd5Vz\WRiYX\0[ZIhOTBibXnud{BjgSCHTFnTRUBu\XSqb3SsJGlEPTBiPTCwMlAyQDlizszNMi=>	NHvTcFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i5OFU5QSd-Mke4PVQ2QDl:L3G+
SF539	MWTGeY5kfGmxbjDhd5NigQ>?		NHPQWnM3OCCvaX7z		MVjJcohq[mm2aX;uJI9nKFCGR1\SMYJmfGFiaX6gbJVu[W5iU1[1N\|kh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIGDES2YuSkJiaX7keYNm\CCyaH;zdIhwenmuYYTpc44heHKnaX7jeYJifGWmIH\vdkA3OCCvaX7zJIZwdGyxd3XkJIJ6KFCGR1[tRmIh[WSmaYTpc44hdWWjc4Xy[YQh[W[2ZYKgNVAhdWmwczDifUBGVEmVQTDt[ZRpd2RuIFnDOVAhRSByLkC4N\|Eh\|ryPLh?=	NVzkN3NGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4PVQ2QDlpPkK3PFk1PTh7PD;hQi=>
HuH7	NUPUWIR7T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NVyybmF4PDhiaILz		NUnVfmZXT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUHWKNzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOy5yMzFOwG0v	NHK3fpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m1OlM1PCd-Mke5OVY{PDR:L3G+
HCT116	NEfqe5RIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MoXTOFghcHK\|		M1KyR2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS54MjFOwG0v	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl3NkO0OEc,Ojd7NU[zOFQ9N2F-
SW620	NHLGRVFIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MmHLOFghcHK\|		MmnKS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gV3c3OjBiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFYvOjVizszNMi=>	MlfiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7NU[zOFQoRjJ5OUW2N\|Q1RC:jPh?=
MV4-11	MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NUjVOpVQPzJiaILz		MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2YND2xNUBk\WyuczDoZZJjd3KrbnegSmxVOyCLVFSgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSByLkCzPFUh\|ryPLh?=	Ml3wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlgoRjJ6MEO4N\|I5RC:jPh?=
CHO	M4SzbGZ2dmO2aX;uJIF{e2G7				M133UGlvcGmkaYTpc44hd2ZiaIXtZY4hTVKJIHX4dJJme3OnZDDpckBEUE9iY3XscJMh[nliUYDheINpKGG\|c3H5MEBKSzVyIE2gNE42KM7:TT6=	NF65Xo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECzPFMzQCd-MkiwN\|g{Ojh:L3G+
HepG2	NGn5dHpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NWDwW2JTPDhiaILz		NX\Ob3o6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNVYvODZizszNMi=>	Mlm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyNUe0NlMoRjJ6MEW3OFI{RC:jPh?=
MCF7	NGPHR41CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NYG0XpZsPDhiaILz		NVT5U2prSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCyOU41OSEQvF2u	NH64WYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC1O\|QzOyd-MkiwOVc1OjN:L3G+
HEK293	NFjq[45HfW6ldHnvckBie3OjeR?=		M17OTlIhdWmwcx?=		M2qxRWlvcGmkaYTpc44hd2ZiaIXtZY4hV0OWMTDlfJBz\XO\|ZXSgbY4hUEWNMkmzJINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHWydHHr[UBw\iCDU2CrJIFnfGW{IEKgcYlveyCkeTDmcJVwemW\|Y3XuZ4Uh[XO\|YYmsJGlEPTBiPTC2MlEh\|ryPLh?=	M2fCVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkOwPVg2Lz5{OEKzNFk5PTxxYU6=
RCC4	NVjmSJEzSW62aXPhcoNmeiCjc4PhfS=>		NX3RenJkPDhiaILz		NX7w[ppMSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJHJESzRiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JHhVXCCjc4PhfUwhUUN3MDC9JFQh\|ryPLh?=	MlrwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|MkW2NFAoRjJ6M{K1OlAxRC:jPh?=
MDA-MB-231	NUT4UJNMSW62aXPhcoNmeiCjc4PhfS=>		M4XOcFQ5KGi{cx?=		NI\OZ\|hCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB2ODDodpMh[nliWGTUJIF{e2G7LDDJR\|UxKD1iNjFOwG0v	M2X6c\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{K1OlAxLz5{OEOyOVYxODxxYU6=
COLO205	MYfDfZRwfG:6aXPpeJkh[XO\|YYm=		MXKyOEBpenN?		MoPoR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR29NVzJyNTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQCEQvF2u	NV3HeJRNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVYxOjRpPkK4O\|U3ODJ2PD;hQi=>
K562	M135b2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MUGyOEBpenN?		NWTWcIFPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTRizszNMi=>	MnXsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NU[wNlQoRjJ6N{W2NFI1RC:jPh?=
MDA-MB-231	MUXDfZRwfG:6aXPpeJkh[XO\|YYm=		NX[2RYh2OjRiaILz		MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy\|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB\|MjFOwG0v	NY\oWnlNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVYxOjRpPkK4O\|U3ODJ2PD;hQi=>
MDA-MB-231	M1fZPWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NG\sSnQzPCCqcoO=		MoLTR5l1d3SxeHnjbZR6KGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDZwOUig{txONg>?	NUezcJI{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OlA{OTNpPkK4O\|YxOzF\|PD;hQi=>
MCF7	NWnLXWFiTnWwY4Tpc44h[XO\|YYm=	Ml3YOEB2VQ>?	M36xZVI1KGi{cx?=		NHHwPGFKdmirYnn0bY9vKG:oIG\FS2ZTOiCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hVUOINzDj[YxteyCjdDC0JJVOKGmwY4XiZZRm\CCob4KgNlQhcHK\|IHL5JHdme3Sncn6gZoxwfCCvZYToc4Q>	MlWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NEKxNVMoRjJ6OUSyNVE{RC:jPh?=
GISTT1	MlPzR5l1d3SxeHnjbZR6KGG\|c3H5		MYC3NkBpenN?		M2Szd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdKW1SWMTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZJIdG9iYYPzZZktKEeLNUCgQUAxNjB2IN88UU4>	NFL4SXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm5NVQ3PSd-Mki5PVE1PjV:L3G+
GISTT1	MYrDfZRwfG:6aXPpeJkh[XO\|YYm=		Mn3JO\|IhcHK\|		M4LCfGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdKW1SWMTDj[YxteyCqYYLic5JqdmdiS1nUJHQ3PzCLIH31eIFvfCCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZJIdG9iYYPzZZktKEeLNUCgQUAxNjB7IN88UU4>	M3jxWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUmxOFY2Lz5{OEm5NVQ3PTxxYU6=
GIST430	M2TZNGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NYi0clJ7PzJiaILz		M4LIOmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdKW1R2M{CgZ4VtdHNiaHHyZo9zcW6pIFvJWEBXPjV2QTDteZRidnRiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzT2yxIHHzd4F6NCCJSUWwJF0hOC5yOUig{txONg>?	M4jyOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUmxOFY2Lz5{OEm5NVQ3PTxxYU6=
GISTT1	MYnDfZRwfG:6aXPpeJkh[XO\|YYm=		Ml\sO\|IhcHK\|		NWDPXotZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hT0mVVGSxJINmdGy\|IHjhdoJwemmwZzDLTXQhTDhzNlWgcZV1[W62IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmekeubzDhd5NigSxiR1m1NEA:KDVwOEig{txONg>?	Ml;JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7OUG0OlUoRjJ6OUmxOFY2RC:jPh?=
HuH7	NILGRZRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MX60PEBpenN?		M2jHdmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSIXIO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iND63NFch\|ryPLh?=	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTB3N{C0Nkc,OjlyNUewOFI9N2F-
A498	NWrQbJRDSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M3vQNFQ5KGi{cx?=		MmXFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDNEm4JINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5Lkm4NUDPxE1w	MlvwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyNUewOFIoRjJ7MEW3NFQzRC:jPh?=
NCI-H727	M{LIUWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NYXZZ\|JIPDhiaILz		NXL0RY8ySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDd{NzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTBwMUKg{txONg>?	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTB3N{C0Nkc,OjlyNUewOFI9N2F-
MV4-11	MWXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		Mm\BO\|IhcHK\|		NYridJo4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGy2aYTldk1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjBzIN88UU4>	MnnYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7M{W3O\|IoRjJ7OUO1O\|czRC:jPh?=
HuH7	NWOxbWp4SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=				MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEi3SEegZ4VtdHNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gN{4xOyEQvF2u	MkPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNUm4NFMoRjNyMEW5PFA{RC:jPh?=
HCT116	MlfwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?				MoXDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKQ2SxNVYh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS54MjFOwG0v	MnXWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNUm4NFMoRjNyMEW5PFA{RC:jPh?=
SW620	M{TqWGFvfGmycn;sbYZmemG2aY\lJIF{e2G7				MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOZNkKwJINmdGy\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFYvOjVizszNMi=>	NEXQOJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC1PVgxOyd-M{CwOVk5ODN:L3G+
HepG2	M4q0OWFvfGmycn;sbYZmemG2aY\lJIF{e2G7				MnG4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKZYDHNkBk\WyuczDifUBOXFRiYYPzZZktKEmFNUCgQUA4Njd6IN88UU4>	Mn20QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNUm4NFMoRjNyMEW5PFA{RC:jPh?=
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EoL-1-cell	MojFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlrCTWM2OD1zLk[0JJBO	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
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EMG-01	Mlq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWnJR\|UxRTFwOEO1OlMh\|ryP	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
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RPMI-8402	M2XEcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1TSTGlEPTB;Mj6zN\|YyQCEQvF2=	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
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KM-H2	NWD4[nZKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXqwSpdwUUN3ME20OE46PTd5IN88US=>	M3HtOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SK-UT-1	M2frN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHLiV4dKSzVyPUS5Mlg5OjVizszN	Mn7VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-STAT3 / STAT3 / p-Src / Src / p-AKT / AKT / p-ERK / ERK ; PubMed: 19244102 Cancer Res Sunitinib reduced Stat3 and Src activity, with no dramatic reduction of AKT, MAPK and JAK signaling in 786-O cells. Tumor cells were treated with sunitinib at indicated concentrations for 2 h (left panels) or 24 h (right panels). Total cell lysates were prepared and western blots were performed using relevant antibodies to detect total protein levels, with β-actin used as the loading control. p-GSK3β / GSK3β / MYCN ; PubMed: 24759734 PLoS One Effect of sunitinib on GSK3β phosphorylation and on MYCN total protein in MYCN amplified NB cell lines. p-AKT / AKT / p-ERK / ERK; PubMed: 24759734 PLoS One Effect of 72 h treatment with sunitinib on SH-SY5Y, SK N BE(2), SK-N-AS and IMR-32 NB cell lines analyzed by Western blot with pSer473Akt, Akt, pThr202/Thr204 Erk1/2 and Erk1/2 antibodies. β-actin was used as a loading control.	19244102 24759734
Growth inhibition assay	Cell viability; PubMed: 24369536 Biomed Res Int Isolated effects of sunitinib malate on urinary bladder-cancer cell lines viability, assessed by using the MTT assay. The data shown and bars represent the mean values ± SD (SD: standard deviation). *P < 0.05 versus untreated cells.	24369536

In vivo

Consistent with the substantial and selective inhibition of VEGFR2 or PDGFR phosphorylation and signaling in vivo, Sunitinib (20-80 mg/kg/day) exhibits broad and potent dose-dependent anti-tumor activity against a variety of tumor xenograft models including HT-29, A431, Colo205, H-460, SF763T, C6, A375, or MDA-MB-435. Sunitinib dosing at 80 mg/kg/day for 21 days leads to complete tumor regression in six of eight mice, without tumor re-growing during a 110-day observation period after the end of treatment. Second round of treatment with Sunitinib remains efficacious against tumors that are not fully regressed during the first round of treatment. Sunitinib treatment results in significant decrease in tumor MVD, with ~40% reduction in SF763T glioma tumors. SU11248 treatment results in a complete inhibition of additional tumor growth of luciferase-expressing PC-3M xenografts, despite no reduction in tumor size. ^[2] Sunitinib treatment (20 mg/kg/day) dramatically suppresses the growth subcutaneous MV4;11 (FLT3-ITD) xenografts and prolongs survival in the FLT3-ITD bone marrow engraftment model. ^[3]

Protocol

Kinase Assay: ^[1]	- Collapse Biochemical Tyrosine Kinase Assays: IC50 values for Sunitinib against VEGFR2 (Flk-1) and PDGFRβ are determined using glutathione S-transferasefusion proteins containing the complete cytoplasmic domain of the RTK. Biochemical tyrosine kinase assays to quantitate the trans-phosphorylation activity of VEGFR2 (Flk-1) and PDGFRβ are performed in 96-well microtiter plates precoated (20 μg/well in PBS; incubated overnight at 4 °C) with the peptide substrate poly-Glu,Tyr (4:1). Excess protein binding sites are blocked with the addition of 1-5% (w/v) BSA in PBS. Purified GST-fusion proteins are produced in baculovirus-infected insect cells. GST-VEGFR2 and GST-PDGFRβ are then added to the microtiter wells in 2 × concentration kinase dilution buffer consisting of 100 mM HEPES, 50 mM NaCl, 40 μM NaVO₄, and 0.02% (w/v) BSA. The final enzyme concentration for GST-VEGFR2 or GST-PDGFRβ is 50 ng/mL. Twenty-five μL of diluted Sunitinib are subsequently added to each reaction well to produce a range of inhibitor concentrations appropriate for each enzyme. The kinase reaction is initiated by the addition of different concentrations of ATP in a solution of MnCl₂ so that the final ATP concentrations spanned the Km for the enzyme, and the final concentration of MnCl₂ is 10 mM. The plates are incubated for 5-15 minutes at room temperature before stopping the reaction with the addition of EDTA. The plates are then washed three times with TBST. Rabbit polyclonal antiphosphotyrosine antisera are added to the wells at a 1:10,000 dilution in TBST containing 0.5% (w/v) BSA, 0.025% (w/v) nonfat dry milk, and 100 μM NaVO₄ and incubated for 1 hour at 37 °C. The plates are then washed three times with TBST, followed by the addition of goat antirabbit antisera conjugated with horseradish peroxidase (1:10,000 dilution in TBST). The plates are incubated for 1 hour at 37 °C and then washed three times with TBST. The amount of phosphotyrosine in each well is quantitated after the addition of 2,2′-azino-di-[3-ethylbenzthiazoline sulfonate] as substrate.
Cell Research: ^[3]	- Collapse Cell lines: RS4;11, MV4;11, and OC1-AML5 Concentrations: Dissolved in DMSO, final concentrations ~10 μM Incubation Time: 24 and 48 hours Method: Cells are starved overnight in medium containing 0.1% FBS prior to addition of Sunitinib and FL (50 ng/mL; FLT3-WT cells only). Proliferation is measured after 48 hours of culture using the Alamar Blue assay or trypan blue cell viability assays. Apoptosis is measured 24 hours after Sunitinib addition by Western blotting to detect cleavage of poly (ADP-ribose) polymerase (PARP) or levels of caspase-3. (Only for Reference)
Animal Research: ^[2]	- Collapse Animal Models: Female nu/nu mice implanted s.c. with HT-29, A431, Colo205, H-460, SF763T, C6, A375, or MDA-MB-435, and male nu/nu mice bearing luciferase-expressing PC-3M tumors Dosages: ~80 mg/kg Administration: Orally once daily (Only for Reference)

References

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Solubility (25°C)

In vitro	DMSO	15 mg/mL (28.16 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 4% DMSO+30% PEG 300+ddH2O For best results, use promptly after mixing.	2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Sunitinib (SU11248) malate SDF

Molecular Weight	532.56
Formula	C₂₂H₂₇FN₄O₂.C₄H₆O₅
CAS No.	341031-54-7
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO+ % + % Tween 80+ % ddH₂O

Calculate Reset

Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04669366	Recruiting	Drug: sunitinib\|Drug: axitinib	Kidney Neoplasms	Pfizer	January 20 2021	--
NCT04633122	Recruiting	Drug: Ripretinib\|Drug: Sunitinib	Gastrointestinal Stromal Tumor(GIST)	Zai Lab (Shanghai) Co. Ltd.	November 25 2020	Phase 2
NCT04115189	Completed	Drug: Sunitinib	Metastatic Renal Cell Carcinoma ( mRCC)	Pfizer	December 13 2019	--
NCT03916458	Completed	--	Carcinoma Renal Cell	Pfizer	December 17 2019	--
NCT04175262	Completed	Drug: sunitinib	Metastatic Renal Cell Carcinoma (mRCC)	Pfizer\|IMDC group\|Analysis Group	October 31 2019	--
NCT04033991	Completed	Drug: Sunitinib\|Drug: Axitinib	Carcinoma\|Renal Cell	Pfizer	September 27 2019	--

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
I was wondering that the compound is in its cis or trans form?
Answer:
S1042 Sunitinib Malate is Z form.
Question 2:
What is the difference between Sunitinib Malate(S1042) and Sunitinib(S7781)?
Answer:
S1042 is the Malate salt form of Sunitinib. The biological activities of these two compounds are the same but the solubility of these two compounds in aqueous solvent are different.

PDGFR Signaling Pathway Map

PDGFR Inhibitors with Unique Features

Selective VEGFR Inhibitors

Vandetanib (ZD6474) : VEGFR2-selective, IC50=40 nM.
Most Potent VEGFR Inhibitor

Cabozantinib (XL184, BMS-907351) : VEGFR2, IC50=0.035 nM.
FDA-approved VEGFR Inhibitor

Axitinib : Approved by FDA for Renal Cell Carcinoma.
Classic VEGFR Inhibitor

Nintedanib (BIBF 1120) : Potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. Phase 3.

Related PDGFR Products

Sunitinib (SU11248) ^New

Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.
Erlotinib (OSI-774) ^New

Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.
Bemcentinib (R428) ^New

Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).
CP-673451

CP-673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM in cell-free assays, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity.
Imatinib (STI571)

Imatinib (STI571, CGP057148B, Gleevec) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib (STI571) induces autophagy.
Crenolanib (CP-868596)

Crenolanib (CP-868596, ARO 002) is a potent and selective inhibitor of PDGFRα/β with K_d of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.
Tyrphostin AG 1296

Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. Tyrphostin AG1296 inhibits FGFR and c-Kit with IC50 of 12.3 μM and 1.8 μM in Swiss 3T3 cells. Tyrphostin AG1296 induces dramatic apoptosis in A375R cells.
Sennoside B

Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
Gefitinib (ZD1839)

Gefitinib (ZD-1839, Iressa) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway.

Features:A potent EGFR tyrosine kinase inhibitor.

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Sunitinib (SU11248) malate