Sunitinib Malate

Name: Sunitinib Malate
Brand: Selleck Chemicals
SKU: S1042
Rating: 5 (99 reviews)

For research use only.

Licensed by Pfizer Catalog No.S1042 Synonyms: SU 11248 Malate

99 publications

CAS No. 341031-54-7

Sunitinib Malate (SU 11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.

Selleck's Sunitinib Malate has been cited by 99 publications

Cancer Cell, 2019, 36(2):179-193

PubMed: 31378681 ( click the link to review the publication )

Cell, 2019, 36(2):179-193

PubMed: 28162770 ( click the link to review the publication )

Nature, 2011, 478(7369):349-55

PubMed: 21993628 ( click the link to review the publication )

Adv Sci (Weinh), 2021, 8(2):2001596

PubMed: 33510997 ( click the link to review the publication )

Drug Metab Dispos, 2021, 49(1):53-61

PubMed: 33148688 ( click the link to review the publication )

Mol Med Rep, 2021, 23(1)40

PubMed: 33179075 ( click the link to review the publication )

Cancers (Basel), 2021, 13(4)653

PubMed: 33562152 ( click the link to review the publication )

Eur J Pharmacol, 2021, 895:173868

PubMed: 33460613 ( click the link to review the publication )

Nat Protoc, 2020, 15(2):421-449

PubMed: 31932771 ( click the link to review the publication )

Cancer Res, 2020, canres.1992.2020

PubMed: 33203698 ( click the link to review the publication )

J Clin Med, 2020, 9(3)

PubMed: 32131507 ( click the link to review the publication )

Front Oncol, 2020, 10:516552

PubMed: 33072561 ( click the link to review the publication )

J Cell Mol Med, 2020, 24(24):14441-14452

PubMed: 33145941 ( click the link to review the publication )

Cancer Cell Int, 2020, 19;20:58

PubMed: 32099531 ( click the link to review the publication )

Metabolites, 2020, 11(1)E1

PubMed: 33374949 ( click the link to review the publication )

PLoS One, 2020, 15(8):e0232917

PubMed: 32810161 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00420-z

PubMed: 32870449 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00425-8

PubMed: 32886306 ( click the link to review the publication )

Neoplasia, 2020, 22(10):470-483

PubMed: 32818841 ( click the link to review the publication )

Cell Syst, 2019, 8(2):97-108

PubMed: 30797775 ( click the link to review the publication )

FASEB J, 2019, 33(1):1347-1359

PubMed: 30148679 ( click the link to review the publication )

Oncoimmunology, 2019, 8(2):e1543526

PubMed: 30713805 ( click the link to review the publication )

Biomolecules, 2019, 9(11)

PubMed: 31683643 ( click the link to review the publication )

Expert Opin Ther Targets, 2019, 23(9):805-817

PubMed: 31385548 ( click the link to review the publication )
IEEE Trans Biomed Eng, 2019, 66(3):873-880

PubMed: 30059292 ( click the link to review the publication )

Sci Rep, 2019, 9(1):1897

PubMed: 30760778 ( click the link to review the publication )

Sci Rep, 2019, 9(1):6004

PubMed: 30979919 ( click the link to review the publication )

Oncol Rep, 2019, 42(5):2039-2048

PubMed: 31485624 ( click the link to review the publication )

AAPS PharmSciTech, 2019, 20(7):281

PubMed: 31399890 ( click the link to review the publication )

Pharm Biol, 2019, 57(1):625-631

PubMed: 31545912 ( click the link to review the publication )

Theranostics, 2018, 8(1):141-155

PubMed: 29290798 ( click the link to review the publication )

EBioMedicine, 2018, 27:225-236

PubMed: 29289530 ( click the link to review the publication )

Cancers (Basel), 2018, 10(10)E365

PubMed: 30274248 ( click the link to review the publication )

Endocr Relat Cancer, 2018, 25(4):471-480

PubMed: 29440231 ( click the link to review the publication )

J Lipid Res, 2018, 59(11):2188-2201

PubMed: 30173145 ( click the link to review the publication )

Chem Biol Interact, 2018, 294:1-8

PubMed: 30125546 ( click the link to review the publication )

Transl Oncol, 2018, 11(6):1406-1418

PubMed: 30219696 ( click the link to review the publication )

Assay Drug Dev Technol, 2018, 16(7):408-419

PubMed: 29985634 ( click the link to review the publication )

Cancer Chemother Pharmacol, 2018, 82(1):65-75

PubMed: 29721849 ( click the link to review the publication )

Cell Death Dis, 2018, 9(10):1018

PubMed: 30282966 ( click the link to review the publication )

J Clin Invest, 2017, 127(4):1338-1352

PubMed: 28240606 ( click the link to review the publication )

Cancer Res, 2017, 77(4):1008-1020

PubMed: 28011623 ( click the link to review the publication )

Arch Toxicol, 2017, 91(8):2921-2938

PubMed: 28032146 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(11):2502-2515

PubMed: 28729403 ( click the link to review the publication )

Hum Mol Genet, 2017, 26(22):4375-4387

PubMed: 28973155 ( click the link to review the publication )

J Am Heart Assoc, 2017, 6(10)

PubMed: 29051215 ( click the link to review the publication )

J Biol Chem, 2017,

PubMed: 27903634 ( click the link to review the publication )

Oncotarget, 2017, 8(40):68270-68279

PubMed: 28978115 ( click the link to review the publication )
Oncotarget, 2017, 9(1):802-811

PubMed: 29416656 ( click the link to review the publication )

Oncotarget, 2017, 8(13):20881-20894

PubMed: 28152509 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2016, 113(33):9339-44

PubMed: 27482107 ( click the link to review the publication )

Elife, 2016, 5e11405

PubMed: 27841748 ( click the link to review the publication )

Oncogene, 2016, 35(21):2687-97

PubMed: 26364599 ( click the link to review the publication )

Dis Esophagus, 2016, 29(8):1144-1151

PubMed: 26542732 ( click the link to review the publication )

Oncol Lett, 2016, 12(6):4671-4676

PubMed: 28105174 ( click the link to review the publication )

Oncotarget, 2016, 7(29):45015-45026

PubMed: 27304187 ( click the link to review the publication )

Sci Transl Med, 2015, 7(284):284ra57

PubMed: 25904741 ( click the link to review the publication )

Neurobiol Dis, 2015, 74:114-25

PubMed: 25461258 ( click the link to review the publication )

Exp Cell Res, 2015, 332(1):1-10

PubMed: 25637219 ( click the link to review the publication )

Biochem Biophys Res Commun, 2015, 10.1016/j.bbrc.2015.04.107

PubMed: 25935484 ( click the link to review the publication )

Pulm Pharmacol Ther, 2015, 10.1016/j.pupt.2015.03.001

PubMed: 25843005 ( click the link to review the publication )

Clin Cancer Res, 2014, 20(9):2410-23

PubMed: 24573550 ( click the link to review the publication )

Leukemia, 2014, 28(11):2197-205

PubMed: 24699302 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2014, 111(14):5319-24

PubMed: 24623852 ( click the link to review the publication )

Ann Surg, 2014, 259(4):793-9

PubMed: 24045439 ( click the link to review the publication )

Int J Cancer, 2014, 10.1002/ijc.29414

PubMed: 25556636 ( click the link to review the publication )

Oncogene, 2014, 33(19):2531-9

PubMed: 23728343 ( click the link to review the publication )

Br J Pharmacol, 2014, 171(24):5728-42

PubMed: 25091695 ( click the link to review the publication )

Br J Cancer, 2014, 111(6):1168-7

PubMed: 25093491 ( click the link to review the publication )

Neurobiol Dis, 2014, 10.1016/j.nbd.2014.10.024

PubMed: ( click the link to review the publication )

Cancer Cell Int, 2014, 14(1):89

PubMed: 25253994 ( click the link to review the publication )

Cancer Cell Int, 2014, 14:89

PubMed: ( click the link to review the publication )
Drug Metab Dispos, 2014, 42(11):1851-7

PubMed: 25165131 ( click the link to review the publication )

Cell Cycle, 2014,

PubMed: 25426675 ( click the link to review the publication )

Cell Cycle, 2014, 13(24):3808-17

PubMed: ( click the link to review the publication )

Transl Oncol, 2014, 19(9):2368-80

PubMed: 23633458 ( click the link to review the publication )

PLoS One, 2014, 9(1):e85759

PubMed: 24454929 ( click the link to review the publication )

PLoS One, 2014, 9(4):e96024

PubMed: 24770423 ( click the link to review the publication )

Korean J Parasitol, 2014, 52(4):439-41

PubMed: 25246725 ( click the link to review the publication )

Oncotarget, 2014, 5(16):6801-15

PubMed: 25149535 ( click the link to review the publication )

Cytometry A, 2014, 85(6):537-47

PubMed: 24664821 ( click the link to review the publication )

Cancer Res, 2013, 73(23):6886-99

PubMed: 24145351 ( click the link to review the publication )

Cancer Lett, 2013, 340(1):43-50

PubMed: 23811285 ( click the link to review the publication )

Mol Cancer Ther, 2013, 12(10):2018-30

PubMed: 23920274 ( click the link to review the publication )

Apoptosis, 2013, 19(4):682-97

PubMed: 24337903 ( click the link to review the publication )

Mol Cell Endocrinol, 2013, 377(1-2):1-6

PubMed: 23811235 ( click the link to review the publication )

Acta Oncol, 2013, 53(5):637-45

PubMed: 24041258 ( click the link to review the publication )

Am J Nucl Med Mol Imaging, 2013, 3(5):397-407

PubMed: 24116348 ( click the link to review the publication )

SENSOR ACTUAT B-CHEM, 2012, Jin Akagi

PubMed: ( click the link to review the publication )

Surgery, 2012, 152(6):1142-9

PubMed: 23158184 ( click the link to review the publication )

Surgery, 2012, 152(6):1045-50

PubMed: 23102636 ( click the link to review the publication )

J Biomol Screen, 2012, 18(4):388-99

PubMed: 23134735 ( click the link to review the publication )

J Biomol Screen, 2012, 17(6):813-21

PubMed: 22453235 ( click the link to review the publication )

Cell Res, 2011, 21(7):1080-7

PubMed: 21423276 ( click the link to review the publication )

Cancer Res, 2011, 71(5):1637-46

PubMed: 21343392 ( click the link to review the publication )

Mol Cancer Ther, 2011, 10(10):1897-908

PubMed: 21825009 ( click the link to review the publication )
Blood, 2010, 115(23):4725-33

PubMed: 20185585 ( click the link to review the publication )

Dis Model Mech, 2010, 3(5-6):343-53

PubMed: 20335444 ( click the link to review the publication )

Biochem Bioph Res Co, 2010, 398(2):205-11

PubMed: 20599738 ( click the link to review the publication )

Purity & Quality Control

Choose Selective PDGFR Inhibitors

Biological Activity

Description

Targets

IRE1α ^[7] ()	Kit ^[1] (Cell-free assay)	FLT3 ^[1] (Cell-free assay)	PDGFRβ ^[1] (Cell-free assay)	VEGFR2 ^[1] (Cell-free assay)
			2 nM	80 nM

In vitro

Sunitinib also potently inhibits Kit and FLT-3. ^[1] Sunitinib is a potent ATP-competitive inhibitor of VEGFR2 (Flk1) and PDGFRβ with K_i of 9 nM and 8 nM, respectively, displaying >10-fold higher selectivity for VEGFR2 and PDGFR than FGFR-1, EGFR, Cdk2, Met, IGFR-1, Abl, and src. In serum-starved NIH-3T3 cells expressing VEGFR2 or PDGFRβ, Sunitinib inhibits VEGF-dependent VEGFR2 phosphorylation and PDGF-dependent PDGFRβ phosphorylation with IC50 of 10 nM and 10 nM, respectively. Sunitinib inhibits VEGF-induced proliferation of serum-starved HUVECs with IC50 of 40 nM, and inhibits PDGF-induced proliferation of NIH-3T3 cells overexpressing PDGFRβ or PDGFRα with IC50 of 39 nM and 69 nM, respectively. ^[2] Sunitinib inhibits phosphorylation of wild-type FLT3, FLT3-ITD, and FLT3-Asp835 with IC50 of 250 nM, 50 nM, and 30 nM, respectively. Sunitinib inhibits the proliferation of MV4;11 and OC1-AML5 cells with IC50 of 8 nM and 14 nM, respectively, and induces apoptosis in a dose-dependent manner. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
3T3	M{DE[WtqdmG\|ZTDBd5NigQ>?				MV3Jcohq[mm2aX;uJI9nKFCGR1[tbY5lfWOnZDDCdoRWKGmwY3;ydI9z[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEC3JO69VQ>?	NYnhfXNORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2OFYxOTlpPkGyOlQ3ODF7PD;hQi=>
3T3	NXq2[mVwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHW1bVJKdmirYnn0bY9vKG:oIGDsZZRmdGW2LXTldol3\WRiZ4Lve5RpKG[jY4TvdkBqdmS3Y3XkJFNVOyClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODFizszN	M2X3dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkS2NFE6Lz5zMk[0OlAyQTxxYU6=
3T3	M2LCcWZ2dmO2aX;uJGF{e2G7				MVLJcohq[mm2aX;uJI9nKF[jc3P1cIFzKGWwZH;0bIVtcWGuIHfyc5d1cCCoYXP0c5IhemWlZYD0c5Ihf2m2aDDJR\|UxKG:oIECuNFUh\|ryP	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ2NkCxPUc,OTJ4NE[wNVk9N2F-
3T3	Mk\nT4lv[XOnIFHzd4F6		NUX0OlFkOjBibXnu	NHzTRYtFVVOR	MV7D[YxtfWyjcjDpcohq[mm2aX;uJI9nKF[HR1[gbY5lfWOnZDDoeY1idiCNRGKgdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjB{MjFOwG0>	NXfhO5loRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[xOlIxODhpPkG2NVYzODB6PD;hQi=>
NIH3T3	NED1cXVMcW6jc3WgRZN{[Xl?		MlvpNlAhdWmw	NWXZeFgzTE2VTx?=	M{\a[olvcGmkaYSgbJVu[W5iS1TSJItqdmG\|ZTDlfJBz\XO\|ZXSge4l1cCCLQ{WwJI9nKDBwMEG4JO69VQ>?	NHv2Zow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkG2NlAxQCd-MU[xOlIxODh:L3G+
A549	MWjGeY5kfGmxbjDBd5NigQ>?			MkXKSG1UVw>?	M1XZOmlvcGmkaYTpc44hd2ZiYz3N[ZQh\GWyZX7k[Y51KEiJRj3pcoR2[2WmIHj1cYFvKEF3NEmgZ4VtdCCvaXfyZZRqd25id3n0bEBKSzVyIH;mJFIh\|ryP	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR\|NEG0OUc,OTh2M{SxOFU9N2F-
DU145	NHrJb3hHfW6ldHnvckBCe3OjeR?=			MnHJSG1UVw>?	MW\Jcohq[mm2aX;uJI9nKGNvTXX0JIRmeGWwZHXueEBJT0ZvaX7keYNm\CCqdX3hckBFXTF2NTDj[YxtKHOlYYT0[ZJqdmdid3n0bEBKSzVyIH;mJFExKM7:TR?=	M33vNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NEO0NVQ2Lz5zOESzOFE1PTxxYU6=
KB3-1	NYHLbnRUS3m2b4TvfIlkKEG\|c3H5		Ml3iO\|IhcA>?	MYrEUXNQ	M{nDe2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHAu\3BvbnXnZZRqfmViS1KtN{0yKGOnbHzzJJdqfGhiSVO1NEBw\iB{LkOg{txO	M2TtSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m3N\|IzLz5zOUO5O\|MzOjxxYU6=
KBV1	NYnBWWxoS3m2b4TvfIlkKEG\|c3H5		NEnVNJI4OiCq	NFu2e2FFVVOR	NX\ud\|V6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWC2pbInjc5Bzd3SnaX6t[ZhxemW\|c3nu[{BMSlZzIHPlcIx{KHerdHigTWM2OCCxZjC0MlEh\|ryP	M{e3dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m3N\|IzLz5zOUO5O\|MzOjxxYU6=
A375	NGfhVnFEgXSxdH;4bYMhSXO\|YYm=		NVz0[XE{PzJiaB?=	NXfhUlVuTE2VTx?=	MnjWTWM2OD13LkSg{txO	NXTUboRMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm2OVQ1ODhpPkG5OlU1PDB6PD;hQi=>
RS4-11	M3vaTGZ2dmO2aX;uJGF{e2G7		MlzwNkBp		MVLJcohq[mm2aX;uJI9nKE[OVEOgZZV1d3Cqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFk6KM7:TR?=	M{nVZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkW0OFA5Lz5zOU[1OFQxQDxxYU6=
RS4-11	NWfLUXZVTnWwY4Tpc44hSXO\|YYm=		MUmyJIg>		NG[xOJFKdmirYnn0bY9vKG:oIF\MWFMhUVSGIH31eIFvfCCjdYTvdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjB\|NDFOwG0>	NX\EbpZzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm2OVQ1ODhpPkG5OlU1PDB6PD;hQi=>
Sf9	NYTHb5I1U2mwYYPlJGF{e2G7		NGi4[Gc{OCCvaX6=		NXnqN4ZiUW6qaXLpeIlwdiCxZjDHV3QufGGpZ3XkJHZGT0[UIHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOC5zOEWg{txO	MojTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6NUSwOVEoRjF7OEW0NFUyRC:jPh?=
Ba/F3	M2TGfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVTuO2plPzJiaB?=		M3XxR2lEPTB;MT6yJO69VQ>?	M3XEbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUG3NFA1Lz5{MEGxO\|AxPDxxYU6=
BaPTC2	NWHEWmoyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NVz5NVlkPzJiaB?=		MUDJR\|UxRTBwMkKg{txO	MknOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMUewNFQoRjJyMUG3NFA1RC:jPh?=
Sf9	MkDCSpVv[3Srb36gRZN{[Xl?		NFL3eYIyKGh?	MXjEUXNQ	M3Pi[mlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSHnzMZRi\2enZDDSSXQh\XiycnXzd4VlKHerdHigTWM2OCCxZjCxMlMh\|ryP	NGPsV249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGxO\|AxPCd-MkCxNVcxODR:L3G+
H4	NWTTbHQzS3m2b4TvfIlkKEG\|c3H5	NUnldItrOTBizszN			NGTET5RVd3irY3n0fUBqdiCqdX3hckBJPCClZXzsdy=>	NFPOcJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFgxPid-MkCzOVA5ODZ:L3G+
SF-539	MnvET4lv[XOnIFHzd4F6	NWjye4p{OzN\|IN88US=>	NIDDRY03OCCvaX6=	M1P2RWROW09?	NFL6d2tKdmirYnn0bY9vKG:oIGDES2ZT[mW2YTDwbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFEzNjJizszN	NYn1epJ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFM4ODBpPkKwOFA{PzByPD;hQi=>
U251	NGPrT\|hMcW6jc3WgRZN{[Xl?	MlP6N\|M{KM7:TR?=	M{n0SlYxKG2rbh?=	NH2zZZdFVVOR	NV:3SYdDUW6qaXLpeIlwdiCxZjDWSWdHWjJicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCxPE46KM7:TR?=	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODRyM{ewNEc,OjB2MEO3NFA9N2F-
A431	NUi2[m1OU2mwYYPlJGF{e2G7				MkntTY5pcWKrdHnvckBw\iCSRFfGVoJmfGFiZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAyOi5{IN88US=>	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODV3OEC3Nkc,OjB3NUiwO\|I9N2F-
A431	NUT0VYdEU2mwYYPlJGF{e2G7				M4DGcGlvcGmkaYTpc44hd2ZiVlXHSnIzKGW6cILld5Nm\CC5aYToJGlEPTBib3[gNVgvQSEQvF2=	MnfpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3NUiwO\|IoRjJyNUW4NFczRC:jPh?=
HepG2	MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M3;0fVczKGh?		M{\6bWlEPTB;Mz64NUDPxE1?	NWPvc\|VkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1O\|A2OjZpPkKwOVcxPTJ4PD;hQi=>
Kasumi-1	NU\0NJNKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NYXtbGNJPzJiaB?=		MUnJR\|UxRTBwMEG2JO69VQ>?	NX\oS5lSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1O\|A2OjZpPkKwOVcxPTJ4PD;hQi=>
RS4-11	NX21[ox[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M4CyRlczKGh?		MV\JR\|UxRTFizszN	M3vFWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUewOVI3Lz5{MEW3NFUzPjxxYU6=
THP1	M3q2Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		Mn7QO\|IhcA>?		NWnRcWRkUUN3ME2wMlUh\|ryP	NYnYO4l6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1O\|A2OjZpPkKwOVcxPTJ4PD;hQi=>
Kasumi-1	MnzQSpVv[3Srb36gRZN{[Xl?				NWDlWG82UW6qaXLpeIlwdiCxZjDjMWtqfCCjdYTvdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjBzNTFOwG0>	NWHrdHVTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4N\|MxOzlpPkKwPFM{ODN7PD;hQi=>
A549	NHTmNXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NELicJIyPiCq		NWXJOIY5SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsdy=>	MnTuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUC0OlMoRjJzNEWwOFY{RC:jPh?=
HL60	NFLGZlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NVzEeXp6OTZiaB?=		MUPBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKTE[wJINmdGy\|	MofuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUC0OlMoRjJzNEWwOFY{RC:jPh?=
HUVEC	NInX[FVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MmDFNVYhcA>?		M2G1cGlvcGmkaYTpc44hd2ZiVlXHSk1qdmS3Y3XkJINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiMj63OUDPxE1?	NFTEWm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS1NFQ3Oyd-MkG0OVA1PjN:L3G+
HUVEC	M3nG[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MYGxOkBp		Mn;wTY5pcWKrdHnvckBw\iCkRlfGMYlv\HWlZXSgZ4VtdCCycn;sbYZmemG2aX;uJJdqfGhiSVO1NEBw\iB2LkC0JO69VQ>?	NX2xWWZGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ\|PD;hQi=>
IM9	MnPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		Mmn0NVYhcA>?		MnHoRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSV25JINmdGy\|	MkX1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUC0OlMoRjJzNEWwOFY{RC:jPh?=
K562	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MofwNVYhcA>?		NGXyelBCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzz	NWnGbXNKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ\|PD;hQi=>
MDA-MB-231	NIWyRWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NEPme3cyPiCq		MofHRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ\|MTDj[Yxtew>?	M2jp[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEWwOFY{Lz5{MUS1NFQ3OzxxYU6=
H460	MUTDfZRwfG:6aXOgRZN{[Xl?		NFXhR2w4OiCq		MYLJR\|UxRTJwNzFOwG0>	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ{MUi4NEc,OjF4MkG4PFA9N2F-
SMMC7721	MkLhR5l1d3SxeHnjJGF{e2G7		MknUO\|IhcA>?		MlTxTWM2OD14LkS3JO69VQ>?	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ{MUi4NEc,OjF4MkG4PFA9N2F-
WI38	M{nlSWN6fG:2b4jpZ{BCe3OjeR?=		M1vkclczKGh?		MkezTWM2OD16LkW2JO69VQ>?	M4DMPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkKxPFgxLz5{MU[yNVg5ODxxYU6=
HEK293	NIXFVFhMcW6jc3WgRZN{[Xl?	M37TfVExOCCwTR?=	MUGxJIg>		MWnkc4V{KG6xdDDpcohq[mm2IG\FS2YucW6mdXPl[EBifXSxcHjvd5Bpd3K7bHH0bY9vKG:oIIT5do9{cW6nIEGxO\|UhemW\|aXT1[UBwdiCYRVfGVlIh\XiycnXzd4VlKGmwIFjFT\|I6OyClZXzsdy=>	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh6NUK4O{c,OjF6OEWyPFc9N2F-
HUVEC	MXXGeY5kfGmxbjDBd5NigQ>?	NV7TTW5mOSEQvF2=	MnjBNlQhcA>?		NWPXXY5SSW62aXHu[4lw\2WwaXOgZYN1cX[rdImgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iVlXHSk1qdmS3Y3XkJINmdGxibXnndoF1cW:w	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4M{OwOUc,OjF7NkOzNFU9N2F-
HUVEC	NYXYb2IzTnWwY4Tpc44hSXO\|YYm=	MWSxJO69VQ>?	M{DUOlEhcA>?		NUD4eI5XUW6qaXLpeIlwdiCxZjDFVmsheGixc4Doc5J6dGG2aX;uJIF1KFSqckKwNk9VgXJ{MESgbY4hXkWJRj3zeIlufWyjdHXkJGhWXkWF	NGixXHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2N\|MxPSd-MkG5OlM{ODV:L3G+
HUVEC	Mn7YSpVv[3Srb36gRZN{[Xl?	M2DrS\|Eh\|ryP	Mnr0NUBp		MmTkTY5pcWKrdHnvckBw\iCnTl;TJJBpd3OyaH;yfYxifGmxbjDheEBU\XJvMUG3NkBqdiCYRVfGMZN1cW23bHH0[YQhUFWYRVO=	Mnv4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkOzNFUoRjJzOU[zN\|A2RC:jPh?=
HUVEC	MmfRT4lv[XOnIFHzd4F6	NH3rWFMyKM7:TR?=	NFfPWoYyKGh?		M4j0bmlvcGmkaYTpc44hd2ZiVlXHSnIzKHCqb4PwbI9zgWyjdHnvckBifCC2eYKtNVE4PSCrbjDWSWdHNXO2aX31cIF1\WRiSGXWSWM>	M3PuWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[zN\|A2Lz5{MUm2N\|MxPTxxYU6=
HUVEC	NHKwN5NHfW6ldHnvckBCe3OjeR?=	MojhNUDPxE1?	NVvlUnlMOSCq		NUPBb3Rp\G:nczDuc5QhcW6qaXLpeEBCU1RicHjvd5Bpd3K7bHH0bY9vKGG2IGPldk01PzNiaX6gWmVITi2\|dHnteYxifGWmIFjVWmVE	MnPvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkOzNFUoRjJzOU[zN\|A2RC:jPh?=
HL60	MY\DfZRwfG:6aXOgRZN{[Xl?	M4fR[lUxKM7:TR?=	MYS0PEBp	Ml70SG1UVw>?	MV3JR\|UxRTF3LkWg{txO	MkPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMUmxPFgoRjJ{MEG5NVg5RC:jPh?=
K562	NF[wN4pEgXSxdH;4bYMhSXO\|YYm=	MXO1NEDPxE1?	M2mzWVQ5KGh?	NHXkTmRFVVOR	MVzJR\|UxRTJzLkmg{txO	NVmwTZF{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNVkyQDhpPkKyNFE6OTh6PD;hQi=>
PC3	MWTDfZRwfG:6aXOgRZN{[Xl?	NV[xe2J5PTBizszN	MUC0PEBp	MmrnSG1UVw>?	MnHKTWM2OD1{NT6xJO69VQ>?	NITVdow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCxPVE5QCd-MkKwNVkyQDh:L3G+
SF-539	NYe1SZZtU2mwYYPlJGF{e2G7	NH;YfWs{OzNizszN	M36zNVYxKG2rbh?=		NUfmSlB2UW6qaXLpeIlwdiCxZjDQSGdHWmKndHGgeJlzd3OrbnWgb4lv[XOnIHHjeIl3cXS7IHnuJHBFT0ZvQlKtd5RqdXWuYYTl[EBpfW2jbjDTSk02OzliY3XscJMhf2m2aDDJR\|UxKG:oIEGyMlIh\|ryP	M37sdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkC0O\|QyLz5{MkKwOFc1OTxxYU6=
HAEC	NI\l[HFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MojMNVAxKM7:TR?=	MUW3NkBp		NIK1OnVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjBSWMh[2WubIOg[ZhxemW\|c3nu[{BXTUeIUjD3bZRpKEmFNUCgc4YhOC5zIN88US=>	NXrFSWNsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OFQ3PzlpPkKyOFQ1Pjd7PD;hQi=>
HT-29	M4HvOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUKxNFAh\|ryP	NVHBNWpwPzJiaB?=		NIDR[FlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIV5eHKnc4PpcochXkWJRmKge4l1cCCLQ{WwJI9nKDBwM{Og{txO	MlPEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NES2O\|koRjJ{NES0Olc6RC:jPh?=
MV4-11	NEHkNGdEgXSxdH;4bYMhSXO\|YYm=		NGrOeWo4OiCq		NEfxRolKSzVyPUCuNFA{KM7:TR?=	M3ftbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEWyOVE5Lz5{MkS1NlUyQDxxYU6=
HepG2	MlOyR5l1d3SxeHnjJGF{e2G7		MoL0OFghcA>?		NWeyZmtCUUN3ME2xN{4zPCEQvF2=	M1fHUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEizOlA5Lz5{MkS4N\|YxQDxxYU6=
PC9	Mo[1R5l1d3SxeHnjJGF{e2G7		NFLsSHM1QCCq		NVq4OYQ4UUN3ME2xNE46PyEQvF2=	NFK3S4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4N\|YxQCd-MkK0PFM3ODh:L3G+
CAKI-1	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1i2T\|ExOCEQvF2=	NF3oVm01QCCq	NYjyNml1TE2VTx?=	NYT4W4I5T0l3ME2wMlY{KM7:TR?=	MlW5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3NkC2NlcoRjJ{NU[wOlI4RC:jPh?=
EKVX	MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGrGNo8yODBizszN	NV\FWZBwPDhiaB?=	MUTEUXNQ	M{TWPWdKPTB;Nz65JO69VQ>?	Mk\kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3NkC2NlcoRjJ{NU[wOlI4RC:jPh?=
MCF7	M2fPSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MU[xNFAh\|ryP	NGH0S2g1QCCq	NYC2UGx2TE2VTx?=	NG[3TVNIUTVzPUKg{txO	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
MDA-MB-435	NFftUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoGzNVAxKM7:TR?=	M2X3NlQ5KGh?	NWq1RmZTTE2VTx?=	MULHTVUzRTJizszN	NX\6bY1[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OlA3OjdpPkKyOVYxPjJ5PD;hQi=>
OVCAR3	M{n5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmrnNVAxKM7:TR?=	NHzwR\|g1QCCq	M4nqTGROW09?	MXXHTVU{RTNwMjFOwG0>	NV3KWGhDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OlA3OjdpPkKyOVYxPjJ5PD;hQi=>
SNB19	NYnPS5Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoK3NVAxKM7:TR?=	MmTZOFghcA>?	MmrZSG1UVw>?	MVfHTVU1RTFyIN88US=>	MoHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3NkC2NlcoRjJ{NU[wOlI4RC:jPh?=
SW620	NHLEdWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGHjXZAyODBizszN	NH;sclE1QCCq	NYDwPVdRTE2VTx?=	M{DQ[mdKPTV;MT6zJO69VQ>?	M4P1TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NU[wOlI4Lz5{MkW2NFYzPzxxYU6=
TK10	M1q4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH7PflQyODBizszN	Mk\DOFghcA>?	MnrDSG1UVw>?	M{LhR2dKPTZ;Nj6zJO69VQ>?	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
UACC257	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MknHNVAxKM7:TR?=	NWfOfnU1PDhiaB?=	NXeyUJdqTE2VTx?=	NYnlelFNT0l3N{20JO69VQ>?	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
HAEC	NH[yepVEgXSxdH;4bYMhSXO\|YYm=	NV3vV5RIOTByIN88US=>	NHjiSIQ4OiCq	MmLjSG1UVw>?	MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBXTUeIUjDlfJBz\XO\|aX7nJGhCTUNid3n0bEBKSzVyIH;mJFAvOSEQvF2=	Mn3YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzM{G1OFEoRjJ\|MUOxOVQyRC:jPh?=
HT-29	Mk\tR5l1d3SxeHnjJGF{e2G7	NFLHUnMyODBizszN	Ml\rO\|IhcA>?	MlKySG1UVw>?	NYPRPIZnS3m2b4TvfIlkcXS7IHHnZYlve3RiVlXHSnIh\XiycnXzd4lv\yCqdX3hckBJXC1{OTDj[YxteyC5aYToJGlEPTBib3[gNE4{OyEQvF2=	MnzFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzM{G1OFEoRjJ\|MUOxOVQyRC:jPh?=
HCT116	MX7GeY5kfGmxbjDBd5NigQ>?		M{LybFI1KGh?	MkLvSG1UVw>?	MVHBcpRqdWmpcnH0c5J6KGGldHn2bZR6KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDtbYdz[XSrb36=	NF7z[XI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G1N\|IxOCd-MkOxOVMzODB:L3G+
HUVEC	MVnGeY5kfGmxbjDBd5NigQ>?	MkXFNkDPxE1?	MnHXNVghcA>?	M2XKNWROW09?	M1TiOWFvfGmjbnfpc4dmdmmlIHHjeIl3cXS7IHnuJGhWXkWFczD1coRmeiCqeYDvfIlkKGOxbnTpeIlwdiCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHS3YnWg[o9zdWG2aX;u	NHPxcVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G1N\|IxOCd-MkOxOVMzODB:L3G+
ACHN	NFLP[ZVEgXSxdH;4bYMhSXO\|YYm=		NWD5WmF6PiCm		NGHjXFRKSzVyPUKuOUDPxE1?	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN4MEGwOEc,OjN\|NkCxNFQ9N2F-
A498	MX3DfZRwfG:6aXOgRZN{[Xl?	M1LCbFExOCEQvF2=	MYW3NkBp	MorJSG1UVw>?	NVPPb3g3UUN3ME20MlMh\|ryP	MmHDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OEm2NlYoRjJ\|NEi5OlI3RC:jPh?=
HUVEC	NX7kc21bT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M13YNFMh\|ryP	NV;iXZNvOjRiaB?=	MX\EUXNQ	NInjVFNCdnSrYX7nbY9o\W6rYzDhZ5Rqfmm2eTDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIG\FS2YucW6mdXPl[EB1fWKnIH\vdo1ifGmxbjD3bZRpKEWFNUCgc4YhOC54NEWg{txO	NF7BTlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W4N\|kyOSd-MkO1PFM6OTF:L3G+
HUVEC	MWnLbY5ie2ViQYPzZZk>	MVSyNFAh\|ryP		MoDQSG1UVw>?	NH;LdGxKdmirYnn0bY9vKG:oIG\FS2ZTOiCyaH;zdIhwenmuYYTpc44hcW5iZ4Lve5RpKG[jY4Tvdk1{fGmvdXzheIVlKEiXVlXD	M2iyS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NUizPVEyLz5{M{W4N\|kyOTxxYU6=
HUVEC	M2PTVWtqdmG\|ZTDBd5NigQ>?	M2LNU\|IxOCEQvF2=		M2i3cGROW09?	MXHJcohq[mm2aX;uJI9nKF[HR1\SNUBxcG:\|cHjvdplt[XSrb36gbY4h\3Kxd4ToJIZi[3Sxcj3zeIlufWyjdHXkJGhWXkWF	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV6M{mxNUc,OjN3OEO5NVE9N2F-
A549	NVrRc3oxS3m2b4TvfIlkKEG\|c3H5		NUTpeldlPzJiaB?=	MmrDSG1UVw>?	MYrJR\|UxRTJwNESg{txO	M1fK[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkCyOFQyLz5{M{[wNlQ1OTxxYU6=
HCT116	NFPDdnlEgXSxdH;4bYMhSXO\|YYm=		NWHEO3U6PzJiaB?=	M2nZTGROW09?	NVO1eWpxUUN3ME20MlcyKM7:TR?=	M1vXXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkCyOFQyLz5{M{[wNlQ1OTxxYU6=
MCF7	MXPDfZRwfG:6aXOgRZN{[Xl?		NV\semxJPzJiaB?=	NHv4ZnFFVVOR	MWrJR\|UxRTZwMkmg{txO	Mlj5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEK0OFEoRjJ\|NkCyOFQyRC:jPh?=
BGC	NHXseoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NGPrZ3Q4OiCq	MkW0SG1UVw>?	NGW5PWFKSzVyPUSuO\|gh\|ryP	M2e1PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OUm5NFQxLz5{M{m5PVA1ODxxYU6=
BxPC3	NWTHW5RuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M3vGXFczKGh?	NYLTXHR{TE2VTx?=	M4P2TmlEPTB;Mz62N{DPxE1?	NXLyV\|I{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5PVkxPDBpPkKzPVk6ODRyPD;hQi=>
HT-29	M4P0cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVzPWpAyPzJiaB?=	NYXX[lZ{TE2VTx?=	NIC5WFFKSzVyPUGuOFch\|ryP	NEXxfGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1OCd-MkO5PVkxPDB:L3G+
T24	NIPLSIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M{HLOVczKGh?	MUfEUXNQ	Mn7uTWM2OD1{LkS0JO69VQ>?	M{PhO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OUm5NFQxLz5{M{m5PVA1ODxxYU6=
4T1	M3\wT2N6fG:2b4jpZ{BCe3OjeR?=		Ml;nO\|IhcA>?	M{XT[GROW09?	NVHBXWoyUUN3ME2wMlAyPiEQvF2=	NW\3d3ptRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PVA3PTJpPkK0PFkxPjV{PD;hQi=>
MCF7	Mo\kR5l1d3SxeHnjJGF{e2G7		M1jQd\|czKGh?	MYjEUXNQ	MVrJR\|UxRTBwMEK3NUDPxE1?	NITiVmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MCF7	Mk\DR5l1d3SxeHnjJGF{e2G7		MVK3NkBp	M1zHXWROW09?	NEPnXlVKSzVyPUCuNFI6OyEQvF2=	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7ME[1Nkc,OjR6OUC2OVI9N2F-
MDA-MB-231	NE\QeXFEgXSxdH;4bYMhSXO\|YYm=		M2H0T\|czKGh?	MXrEUXNQ	MX\JR\|UxRTBwMEKyN{DPxE1?	NHv3UoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MDA-MB-435	MonMR5l1d3SxeHnjJGF{e2G7		NIrKd284OiCq	MkKwSG1UVw>?	NUHMfIc5UUN3ME2wMlAxQTdizszN	NI\SbpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MDA-MB-468	MlzCR5l1d3SxeHnjJGF{e2G7		NHnEZ2I4OiCq	NFzaVVVFVVOR	MVPJR\|UxRTBwMEC2NUDPxE1?	NYjSNXpWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PVA3PTJpPkK0PFkxPjV{PD;hQi=>
A431	NYrmOHRRU2mwYYPlJGF{e2G7	NYfLRpVkOTBizszN	NXTpNoVkOSCq	MYTEUXNQ	M2TRW2lvcGmkaYTpc44hd2ZiRVfGVkB4cXSqIFnDOVAhd2ZiMD6xO\|IyKM7:TR?=	M1jCRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
SH-SY5Y	MnnnT4lv[XOnIFHzd4F6	MXyxNEDPxE1?	MX2xJIg>	NH:5[nJFVVOR	M3;0SmlvcGmkaYTpc44hd2ZiUFTHSnJj\XSjIIfpeIghUUN3MDDv[kAxNjB6M{Gg{txO	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7ME[1Nkc,OjR6OUC2OVI9N2F-
U251	NFHnUplMcW6jc3WgRZN{[Xl?	NXjMW2s5OTBizszN	MUCxJIg>	MoHtSG1UVw>?	MVrJcohq[mm2aX;uJI9nKF[HR1\SNkB4cXSqIFnDOVAhd2ZiMD6wNVg6KM7:TR?=	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7ME[1Nkc,OjR6OUC2OVI9N2F-
Bel7402	MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MoPxO\|IhcA>?	NIDR[YJFVVOR	MULJR\|UxRTJwNkeg{txO	M334VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
HK2	NFPwN2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MVS3NkBp	MVrEUXNQ	MoXoTWM2OD13Lki1JO69VQ>?	M4e1eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
LO2	M1fq[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NF;NUWM4OiCq	M3S5dGROW09?	M2HYTGlEPTB;MUmuPVMh\|ryP	MlzLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MES5OlEoRjJ2OUC0PVYyRC:jPh?=
MV4-11	NVPw[opMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MmG0OFghcA>?	NFnoVmxFVVOR	MmTGTWM2OD1yLkCwN{DPxE1?	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2NUc,OjR7MES5OlE9N2F-
NCI-H3122	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MoT0O\|IhcA>?	NUPGW5FsTE2VTx?=	MoD6TWM2OD1yLkizJO69VQ>?	MnvTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MES5OlEoRjJ2OUC0PVYyRC:jPh?=
NCI-H460	MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NU\uZWRPPzJiaB?=	M33tV2ROW09?	MnvjTWM2OD12LkOxJO69VQ>?	NEO2R409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwOFk3OSd-MkS5NFQ6PjF:L3G+
NCI-H526	NUXNOndrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MXW3NkBp	Mnj1SG1UVw>?	Mon1TWM2OD1zLkCxJO69VQ>?	NFf6V2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwOFk3OSd-MkS5NFQ6PjF:L3G+
TT	MmPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NUGz[IxUPzJiaB?=	MWPEUXNQ	MoToTWM2OD1yLkC0JO69VQ>?	M2XmSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
3T3	NGPj[4xCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M4q1SVczKGi{cx?=		NGj0PGhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIEPUN{Bk\WyuczDlfJBz\XO\|aX7nJIh2dWGwIFPTSlFTKGGodHXyJFczKGi{czDifUBE\WyudHn0[ZIh[XO\|YYmsJGFkfGm4aYT5JF0hOC5yOTFOwG0v	NGDlb2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[5OFY1OSd-MUi2PVQ3PDF:L3G+
MV4-11	NHHlSGtCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M3rmbFczKGi{cx?=		Mni1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPVkStNVEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFA1OyEQvF2u	NFjqTWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe1OFE6QSd-MUm3OVQyQTl:L3G+
HEK293	M{e4OGZ2dmO2aX;uJIF{e2G7				NUjSc41qSmmwZHnu[{Bi\m[rbnn0fUB1dyCITGSzJINifGGueYTpZ{Bld22jaX6g[ZhxemW\|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBkd22yZYTpeIl3\SCkaX7kbY5oKGG\|c3H5MEBM\CB;IECuNFAxPDdizszNMi=>	NX3KWXJlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OVQyQTlpPkG5O\|U1OTl7PD;hQi=>
FDC-P1	M4Tkd2Z2dmO2aX;uJIF{e2G7		M3\NRVQ5KGi{cx?=		MlG0TY5pcWKrdHnvckBw\iCqdX3hckBHVVNiZYjwdoV{e2WmIHnuJIdzd3e2aDDmZYN1d3JiZHXw[Y5l\W62IH3veZNmKE[GQz3QNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIF\NV{1u\WSrYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44hcW5icILld4Vv[2ViaIXtZY4hS1OIMTDh[pRmeiB2ODDodpMh[nlicnXzZZp2emmwIHT5[UBz\WS3Y4Tpc44h[XO\|YYmsJGlEPTBiPTCwMlE2PSEQvF2u	NVX6flFLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOVY3QDlpPkKwNVU3Pjh7PD;hQi=>
primary leukemia cells	MkDDR5l1d3SxeHnjbZR6KGG\|c3H5		M4\pV\|czKGi{cx?=		M2rUXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJBzcW2jcomgcIV2c2WvaXGgZ4VtdHNiaYPvcIF1\WRiZoLvcUBi[3W2ZTDtfYVtd2mmIHzleYtmdWmjIIDheIlmdnRiZYjwdoV{e2mwZzDGUHQ{NUmWRDDteZRifGmxbjDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nlibIXjbYZmemG\|ZTDhd5NigSxiSVO1NEA:KDBwMEOg{txONg>?	NHPmZnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
primary leukemia cells	MWPDfZRwfG:6aXPpeJkh[XO\|YYm=		NGr1Nng4OiCqcoO=		M{fQRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJBzcW2jcomgcIV2c2WvaXGgZ4VtdHNiaYPvcIF1\WRiZoLvcUBi[3W2ZTDtfYVtd2mmIHzleYtmdWmjIIDheIlmdnRiZYjwdoV{e2mwZzD3bYxlKHS7cHWgSmxVOyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhUUN3MDC9JFAvODNizszNMi=>	NFvOSXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
primary leukemia cells	NGrDVY9EgXSxdH;4bYNqfHliYYPzZZk>		NHvENpg4OiCqcoO=		MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwdolu[XK7IHzleYtmdWmjIHPlcIx{KGm\|b3zheIVlKG[{b32gZYN2fGVibYnlcI9q\CCuZYXr[Y1q[SCyYYTp[Y51KGW6cILld5NqdmdiRlzUN{1FQDN3WTDteZRifGmxbjDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nlibIXjbYZmemG\|ZTDhd5NigSxiSVO1NEA:KDFwMTFOwG0v	NHW3UHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
endothelial precursor cells	NH2zO2VHfW6ldHnvckBie3OjeR?=				M1HSSWlvcGmkaYTpc44hd2ZiZX7kc5Rp\WyrYXygZ49z\CCjcnXhJIZwem2jdHnvckBqdiCnbnTveIhmdGmjbDDwdoVkfXK\|b4KgZ4VtdHNiYomgR2Q{OSClb4LkJIFz\WFiZHX0[YN1cW:wIHLhd4VlKHCqZX7veJlxcWNiZIL1[{BlcXOlb4\ldpkh[mG\|ZXSgZZN{[XluIFnDOVAhRSByLkCwPVYh\|ryPLh?=	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjRyOU[2Okc,OjJ2MEm2OlY9N2F-
endothelial precursor cells	MnXaSpVv[3Srb36gZZN{[Xl?				MoDaTY5pcWKrdHnvckBw\iClZXzsJI1q\3KjdHnvckBqdiCnbnTveIhmdGmjbDDwdoVkfXK\|b4KgZ4VtdHNiYomgU5JqeyClZXzsJI1q\3KjdHnvckBscXRiYnHz[YQheGinbn;0fZBq[yCmcoXnJIRqe2OxdnXyfUBj[XOnZDDhd5NigSxiSVO1NEA:KDF\|Lk[g{txONg>?	MmLVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2MEm2OlYoRjJ{NEC5OlY3RC:jPh?=
U251	NVPjblg{TnWwY4Tpc44h[XO\|YYm=		M3O3[FYxKG2rboO=		NEnIZXNKdmirYnn0bY9vKG:oIG\FS2ZTOiCrbjDoeY1idiCXMkWxJINmdGy\|IIDy[ZRz\WG2ZXSg[o9zKDZyIH3pcpMhdWWjc4Xy[YQh[W[2ZYKgNUBpeiCkeTDFUGlUSSxiSVO1NEA:KDF6Lkmg{txONg>?	NGnoc3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkezPVA6OCd-MkK3N\|kxQTB:L3G+
U251	MWjGeY5kfGmxbjDhd5NigQ>?		M2HH[FYxKG2rboO=		NGrXU5BKdmirYnn0bY9vKG:oIG\FS2YucW6mdXPl[EBXTUeIUkKgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIGWyOVEh[2WubIOgc5ZmemW6cILld5NqdmdiRnzrMVEheHKndILlZZRm\CCob4KgOlAhdWmwczDwdolweiC2bzDWSWdHKGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFExKG2rboOgZpkheGixc4Doc5R6em:\|aX7lJGVNUVODIHP5eI9jdG:2IHHuZYx6e2m\|LDDJR\|UxKD1iMUiuPUDPxE1w	M4LMdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{e1NFkxLz5{M{O3OVA6ODxxYU6=
U251	M{CydGZ2dmO2aX;uJIF{e2G7		Ml;POlAhdWmwcx?=		MUfJcohq[mm2aX;uJI9nKF[HR1\SNkBqdiCqdX3hckBWOjVzIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhXkWJRj3pcoR2[2WmIIT5do9{cW6nIIDoc5NxcG:{eXzheIlwdiCrbnP1ZoF1\WRiZn;yJFYxKG2rboOgdJJqd3JidH:gWmVITi2jY4TpeoF1cW:wIH3lZZN2emWmIEGwJI1qdnNiYomgSWxKW0FuIFnDOVAhRSBzOD65JO69VS5?	M1n3blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEO0NVM6Lz5{M{SzOFE{QTxxYU6=
CHO	NIfvbYdHfW6ldHnvckBie3OjeR?=				MmPLTY5pcWKrdHnvckBw\iCFYY[xMlIh[3W{cnXueEBu\WG\|dYLl[EB2e2mwZzDRVIF1[2hiYYX0c41ifGmlIIDheIgh[2yjbYCgd5l{fGWvIHnuJGNJVyClZXzsd{BmgHC{ZYPzbY5oKEOjdkGuNkwh[mW2YT2yJIFv\CCjbIDoZU0zN2SnbIThMVEhe3WkdX7peJMtKEmFNUCgQUA{Oy52IN88UU4>	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzMkWwN{c,OjN6MUK1NFM9N2F-
U251	MkHESpVv[3Srb36gZZN{[Xl?				MXnJcohq[mm2aX;uJI9nKF[HR1\SNkBqdiCqdX3hckBWOjVzIHPlcIx{KGK7IIDoc5NxcG:2eYLvd4lv\SCHTFnTRUwhUUN3MDC9JFAvODF6OTFOwG0v	NHzJNlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFg3PSd-MkS5NFA5PjV:L3G+
MCF7	NX;6eFJSSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NFnUZ\|Q1QCCqcoO=		MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFyLkWg{txONg>?	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB4NEO0O{c,OjVyNkSzOFc9N2F-
HepG2	NW\CPYxvSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M1f1W\|Q5KGi{cx?=		NWXZb4hGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNVMvPiEQvF2u	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB4NEO0O{c,OjVyNkSzOFc9N2F-
CHO	MXrGeY5kfGmxbjDhd5NigQ>?				NIHmZodKdmirYnn0bY9vKG:oIILhdIllKGSnbHH5[YQhcW65YYLkJJJm[3SrZonpcocheG:2YYPzbZVuKGO3coLlcpQhMEmNcjmgbY4hS2irbnXz[UBp[W2\|dHXyJI93[XK7IDjDTG8qKGOnbHzzJJN1[WKuZTDlfJBz\XO\|aX7nJIhGWkdibXXhd5Vz\WRidYPpcochUW:wV3;yb5MhSmG{cnHjeYRiKGG3dH;tZZRm\CCyYYTjbEBkdGGvcDDwcIF1\m:{bTygTWM2OCB;IEeuPVQ{OjhizszNMi=>	Ml7yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEe3OVMoRjJ3MEi3O\|U{RC:jPh?=
CHO K1	NVHFVo1vTnWwY4Tpc44h[XO\|YYm=				M{\LTWlvcGmkaYTpc44hd2ZicnHwbYQh\GWuYYnl[EBqdnejcnSgdoVkfGmoeXnu[{Bxd3Sjc4PpeY0h[3W{cnXueEApUUu{KTDpckBEcGmwZYPlJIhidXO2ZYKgc5ZienliKFPIU{khUzFiY3XscJMhe3SjYnz5JIV5eHKnc4PpcochcEWURzDt[YF{fXKnZDD1d4lv\yCLb37Xc5JseyCTdXH0eJJwKGG3dH;tZZRm\CCyYYTjbEBkdGGvcDDwcIF1\m:{bTygTWM2OCB;IEGwJO69VS5?	MlH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEe3OVMoRjJ3MEi3O\|U{RC:jPh?=
CHO K1	M{Hs[2Z2dmO2aX;uJIF{e2G7				NVLKVW97UW6qaXLpeIlwdiCxZjDmZZN1KHOxZHn1cUBkfXK{ZX70JEhKVmFrIHnuJGNpcW6nc3WgTIFue3SncjDPeoFzgSBqQ1jPLUBMOSClZXzsd{B1emGwc3\lZ5Rm\CC5aYToJIh2dWGwIF7helEvPSCvZXHzeZJm\CC3c3nu[{BKd26Zb4Lrd{BSfWG2dILvJIF2fG:vYYTl[EBx[XSlaDDjcIFueCCybHH0[o9zdSxiSVO1NEA:KDF3Lki0PFkh\|ryPLh?=	NV3WSG9sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPFc4PTNpPkK1NFg4PzV\|PD;hQi=>
HEK293	NUfyS\|BuTnWwY4Tpc44h[XO\|YYm=				MnriTY5pcWKrdHnvckBw\iCoYYP0JJNw\Gm3bTDjeZJz\W62IDjJUoEqKGmwIFjFT\|I6OyClZXzsd{B1emGwc3\lZ5Rm\CC5aYToJIh2dWGwIF7helEvPSCvZXHzeZJm\CC3c3nu[{BKd26Zb4Lrd{BSfWG2dILvJIF2fG:vYYTl[EBx[XSlaDDjcIFueCCybHH0[o9zdSxiSVO1NEA:KDN7LkixNFch\|ryPLh?=	NIjMcpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4O\|c2Oyd-MkWwPFc4PTN:L3G+
MOLM13	MnjHR5l1d3SxeHnjbZR6KGG\|c3H5		NFT3SpE1QCCqcoO=		MUHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNU2xOOTNiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODF5NzFOwG0v	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB6OUixNEc,OjVyOEm4NVA9N2F-
MV4-11	M2LuTGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NYrMUJg4PDhiaILz		NEPQdZVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOXjRvMUGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMEK0N{DPxE1w	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB6OUixNEc,OjVyOEm4NVA9N2F-
HL60	M13wXWN6fG:2b4jpZ4l1gSCjc4PhfS=>		MoLyOFghcHK\|		M1;FcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNPjBiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODN4ODFOwG0v	MnLpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEm4NVAoRjJ3MEi5PFExRC:jPh?=
THP1	MkjXR5l1d3SxeHnjbZR6KGG\|c3H5		M1zEZVQ5KGi{cx?=		NIjBb4REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVUFBzIHPlcIx{KGG\|c3Xzd4VlKGG\|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB2NUeg{txONg>?	NV7Qb3Z6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPFk5OTBpPkK1NFg6QDFyPD;hQi=>
ACHN	NVLVeY43S3m2b4TvfIlkcXS7IHHzd4F6		MUG3NkBpenN?		MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBR2hPKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCyJO69VS5?	MnnmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzMkSxNVQoRjJ3MUK0NVE1RC:jPh?=
U251	MWrGeY5kfGmxbjDhd5NigQ>?		NX71OHRnPjBibXnu		MXjJcohq[mm2aX;uJI9nKF[HR1\SNkBqdiCqdX3hckBWOjVzIHPlcIx{KGOxbYDveY5lKHC{ZYTy[YF1\WRiZn;yJFYxKG2rbjDi[YZwemViVlXHSkB{fGmvdXzheIlwdiCob4KgNVAhdWmwczDifUBxcG:\|cHjveJlzd3OrbnWgSWxKW0FiY4n0c4Jtd3RibXX0bI9lNCCLQ{WwJF0hOC5yMUi5JO69VS5?	NYDH[GY2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFI2OTlpPkK1PFgzPTF7PD;hQi=>
U251	Mmn4SpVv[3Srb36gZZN{[Xl?		NVjzVmhZPjBibXnu		M1Hv[WlvcGmkaYTpc44hd2ZiUFTHSnIu[mW2YTDpckBpfW2jbjDVNlUyKGOnbHzzJINwdXCxdX7kJJBz\XS{ZXH0[YQh\m:{IE[wJI1qdiCkZX\vdoUhWESJRj3CRkB{fGmvdXzheIlwdiCob4KgNVAhdWmwczDifUBxcG:\|cHjveJlzd3OrbnWgSWxKW0FiY4n0c4Jtd3RibXX0bI9lNCCLQ{WwJF0hOC5yOEOxJO69VS5?	MmH0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6OEK1NVkoRjJ3OEiyOVE6RC:jPh?=
A431	MmfzSpVv[3Srb36gZZN{[Xl?		MlLXOlAhdWmw		M{\OS2lvcGmkaYTpc44hd2ZiRVfGVkBqdiCqdX3hckBCPDNzIHPlcIx{KGOxbYDveY5lKHC{ZYTy[YF1\WRiZn;yJFYxKG2rbjDi[YZwemViRVfGJJN1cW23bHH0bY9vKG[xcjCxNEBucW6\|IHL5JJBpd3OyaH;0fZJwe2mwZTDFUGlUSSCleYTvZoxwfCCvZYToc4QtKEmFNUCgQUAxNjF5MkGg{txONg>?	M1y5OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEiyOVE6Lz5{NUi4NlUyQTxxYU6=
HT-29	MnjkR5l1d3SxeHnjbZR6KGG\|c3H5		NVTWS\|Z1PDhiaILz		MYXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSB2Lkeg{txONg>?	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByOUG2OEc,OjZyMEmxOlQ9N2F-
A549	NYe4V3VPS3m2b4TvfIlkcXS7IHHzd4F6		Mn7wOFghcHK\|		MorER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSB5LkmzJO69VS5?	M{TPfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEC5NVY1Lz5{NkCwPVE3PDxxYU6=
SKOV3	M1\yS2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MWq0PEBpenN?		M3TncWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEmuNlEh\|ryPLh?=	NX64PYtKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wNFkyPjRpPkK2NFA6OTZ2PD;hQi=>
PANC1	MV\DfZRwfG:6aXPpeJkh[XO\|YYm=		M1v5bVQ5KGi{cx?=		NUXp[VZPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEGQQ{GgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG\|c3H5MEBKSzVyIE2gNVQvQTRizszNMi=>	NFjxNWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwPVE3PCd-Mk[wNFkyPjR:L3G+
HepG2	MkXPR5l1d3SxeHnjbZR6KGG\|c3H5		MU[0PEBpenN?		MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSBzNj6wOkDPxE1w	MnTMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEmxOlQoRjJ4MEC5NVY1RC:jPh?=
MCF7	MV3DfZRwfG:6aXPpeJkh[XO\|YYm=		NFHvSYw1QCCqcoO=		NVzEUmJIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTBiPTCyOU41OSEQvF2u	M2Hob\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEC5NVY1Lz5{NkCwPVE3PDxxYU6=
Bel7402	MojGVIhwfG:leYTveI95cWOrdImgZZN{[Xl?		Mnu3OUBpenN?		MXnQbI91d2O7dH;0c5hq[2m2eTDh[4FqdnO2IHj1cYFvKEKnbEe0NFIh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgdJJmcW6ldXLheIVlKG[xcjC1JIhzeyC5aYToJINmdGy\|IH\vcIxwf2WmIHL5JHVXSS1zIHnydoFlcWG2aX;uJIF1KDNwMDDtW{9kdSd{IH\vdkAzOCCvaX7zJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDDR2s5KGG\|c3H5MEBGSzVyIE2gNVEh\|ryPLh?=	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV6NEC4OUc,OjZ3OESwPFU9N2F-
PANC1	NVy0PWExWGixdH;jfZRwfG:6aXPpeJkh[XO\|YYm=		MkK1OUBpenN?		MVHQbI91d2O7dH;0c5hq[2m2eTDh[4FqdnO2IHj1cYFvKFCDTlOxJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IIDy[Ylv[3WkYYTl[EBnd3JiNTDodpMhf2m2aDDj[YxteyCob3zsc5dm\CCkeTDVWmEuOSCrcoLh[IlifGmxbjDheEA{NjBibWevZ40oOiCob4KgNlAhdWmwczDt[YF{fXKnZDDh[pRmeiB2ODDodpMh[nliQ1PLPEBie3OjeTygSWM2OCB;IEGzJO69VS5?	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV6NEC4OUc,OjZ3OESwPFU9N2F-
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MDA-MB-435	MWLDfZRwfG:6aXPpeJkh[XO\|YYm=				MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEO1JINmdGy\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFkvOyEQvF2u	M4jnVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUKwPFAxLz5{NkmyNFgxODxxYU6=
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GIST882	MmCxRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NI\tNVE4OiCqcoO=		M4DnSmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgZ2tKXCCmZYDlcoRmdnRiaIXtZY4hT0mVVEi4NkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNVEh\|ryPLh?=	NGfaW489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BAF3	NHvOZmJHfW6ldHnvckBie3OjeR?=		M3LaR\|czKGi{cx?=		M2fYVmlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhVjh{MlugcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8wS0ONODDhd5NigSxiR1m1NEA:KDBwNUGg{txONg>?	MoXFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
Rec1	NYXmU3FDSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NEnTT2Q4OiCqcoO=		NF2zSotCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGLlZ\|Eh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCwMlg4KM7:TT6=	M3q3VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
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KU812	M1G0UmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NHyxSlU4OiCqcoO=		NXLwTmlHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMJIRmeGWwZHXueEBpfW2jbjDLWVgyOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFEvOSEQvF2u	NVH4V201RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
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U251	MmTHSpVv[3Srb36gZZN{[Xl?		MW[2NEBucW6\|		MXHJcohq[mm2aX;uJI9nKF[HR1\SMVIhcW5iaIXtZY4hXTJ3MTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hXkWJRjDpcoR2[2WmIIDoc5NxcG:{eXzheIlwdiCycnXpcoN2[mG2ZXSg[o9zKDZyIH3pcpMh\m:ubH;3[YQh[nliVlXHSkBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjCxNEBucW6\|IHL5JGVNUVODIH3leIhw\CxiSVO1NEA:KDBwMEG4PUDPxE1w	M4PqblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEm0OVg6Lz5{N{i5OFU5QTxxYU6=
SF539	MWDGeY5kfGmxbjDhd5NigQ>?		NEP3OVY3OCCvaX7z		MnrLTY5pcWKrdHnvckBw\iCSRFfGVk1j\XSjIHnuJIh2dWGwIGPGOVM6KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDQSGdHNUKEIHnu[JVk\WRicHjvd5Bpd3K7bHH0bY9vKHC{ZXnuZ5Vj[XSnZDDmc5IhPjBibXnud{Bnd2yub4fl[EBjgSCSRFfGMWJDKGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFExKG2rboOgZpkhTUyLU1GgcYV1cG:mLDDJR\|UxKD1iMD6wPFMyKM7:TT6=	NVS3[nlwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4PVQ2QDlpPkK3PFk1PTh7PD;hQi=>
HuH7	NXLrd3ppT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NVzaTHk4PDhiaILz		NIDMSHZIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJfUh5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{NjB\|IN88UU4>	MlvhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7NU[zOFQoRjJ5OUW2N\|Q1RC:jPh?=
HCT116	MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MYO0PEBpenN?		MofwS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA2NjZ{IN88UU4>	NY\jRoxIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OVY{PDRpPkK3PVU3OzR2PD;hQi=>
SW620	NV33RotwT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M{H6UVQ5KGi{cx?=		NVHUTVBQT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW1d4MkCgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDZwMkWg{txONg>?	NW[yUGJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OVY{PDRpPkK3PVU3OzR2PD;hQi=>
MV4-11	NYH6cnhmSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M{PVZlczKGi{cx?=		M2fIZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTW[0MVEyKGOnbHzzJIhiemKxcnnu[{BHVFR\|IFnUSEBufXSjboSgZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IECuNFM5PSEQvF2u	M2m5SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEO4N\|I5Lz5{OECzPFMzQDxxYU6=
CHO	NXPpUFRzTnWwY4Tpc44h[XO\|YYm=				NX;N[IpGUW6qaXLpeIlwdiCxZjDoeY1idiCHUleg[ZhxemW\|c3XkJIlvKEOKTzDj[YxteyCkeTDRdIF1[2hiYYPzZZktKEmFNUCgQUAxNjVizszNMi=>	Mm\nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlgoRjJ6MEO4N\|I5RC:jPh?=
HepG2	NGHV[5dCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MYG0PEBpenN?		NYqwSGJ1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNVYvODZizszNMi=>	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB3N{SyN{c,OjhyNUe0NlM9N2F-
MCF7	NYjZU\|ZHSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MWi0PEBpenN?		M2O3fmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMkWuOFEh\|ryPLh?=	M2jhdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEW3OFI{Lz5{OEC1O\|QzOzxxYU6=
HEK293	M2DkdWZ2dmO2aX;uJIF{e2G7		MUmyJI1qdnN?		NIG0U2xKdmirYnn0bY9vKG:oIHj1cYFvKE:FVEGg[ZhxemW\|c3XkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiC3cIThb4Uhd2ZiQWPQL{Bi\nSncjCyJI1qdnNiYomg[ox2d3Knc3PlcoNmKGG\|c3H5MEBKSzVyIE2gOk4yKM7:TT6=	M13nOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkOwPVg2Lz5{OEKzNFk5PTxxYU6=
RCC4	NEK0XJJCdnSrY3HuZ4VzKGG\|c3H5		MWG0PEBpenN?		MWDBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUlPDOEBk\WyuczDh[pRmeiB2ODDodpMh[nliWGTUJIF{e2G7LDDJR\|UxKD1iNDFOwG0v	M{HnZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{K1OlAxLz5{OEOyOVYxODxxYU6=
MDA-MB-231	MmnHRY51cWOjbnPldkBie3OjeR?=		NUPsR\|N7PDhiaILz		MXzBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ\|MTDj[YxteyCjZoTldkA1QCCqcoOgZpkhYFSWIHHzd4F6NCCLQ{WwJF0hPiEQvF2u	MkPzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|MkW2NFAoRjJ6M{K1OlAxRC:jPh?=
COLO205	MXfDfZRwfG:6aXPpeJkh[XO\|YYm=		M3nEOFI1KGi{cx?=		NYXCPXNMS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0:OT{KwOUBk\WyuczDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iODFOwG0v	Mn\OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NU[wNlQoRjJ6N{W2NFI1RC:jPh?=
K562	NEexbJFEgXSxdH;4bYNqfHliYYPzZZk>		M3PWXlI1KGi{cx?=		Ml;tR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNVQh\|ryPLh?=	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd3NkCyOEc,Ojh5NU[wNlQ9N2F-
MDA-MB-231	MULDfZRwfG:6aXPpeJkh[XO\|YYm=		NXPXVppCOjRiaILz		NIPPXZlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCzNkDPxE1w	NF2xdpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEe1OlAzPCd-Mki3OVYxOjR:L3G+
MDA-MB-231	NXTDW2NuS3m2b4TvfIlkcXS7IHHzd4F6		NH21ZZUzPCCqcoO=		NEH3WFdEgXSxdH;4bYNqfHliaX6gbJVu[W5iTVTBMW1DNTJ\|MTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgbY5kfWKjdHXkJIZweiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iNj65PEDPxE1w	MlPBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NkCzNVMoRjJ6N{[wN\|E{RC:jPh?=
MCF7	NGD3W2xHfW6ldHnvckBie3OjeR?=	M{ThelQhfU1?	MmjqNlQhcHK\|		M1vSdGlvcGmkaYTpc44hd2ZiVlXHSnIzKHCqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBOS0Z5IHPlcIx{KGG2IESgeW0hcW6ldXLheIVlKG[xcjCyOEBpenNiYomgW4V{fGW{bjDicI91KG2ndHjv[C=>	NIr6T2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm0NlEyOyd-Mki5OFIyOTN:L3G+
GISTT1	MWrDfZRwfG:6aXPpeJkh[XO\|YYm=		MX[3NkBpenN?		NEH5VWVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBIUVOWVEGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzT2yxIHHzd4F6NCCJSUWwJF0hOC5yNDFOwG0v	M4HNXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUmxOFY2Lz5{OEm5NVQ3PTxxYU6=
GISTT1	MmPWR5l1d3SxeHnjbZR6KGG\|c3H5		NUXpZpdFPzJiaILz		NXnteXJDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hT0mVVGSxJINmdGy\|IHjhdoJwemmwZzDLTXQhXDZ5MFmgcZV1[W62IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmekeubzDhd5NigSxiR1m1NEA:KDBwMEmg{txONg>?	M4TSbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUmxOFY2Lz5{OEm5NVQ3PTxxYU6=
GIST430	MX\DfZRwfG:6aXPpeJkh[XO\|YYm=		MVG3NkBpenN?		MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDHTXNVPDNyIHPlcIx{KGijcnLvdolv\yCNSWSgWlY2PEFibYX0ZY51KGG\|c3Xzd4VlKGG\|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldmdtdyCjc4PhfUwhT0l3MDC9JFAvODl6IN88UU4>	NWi3XJBERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5PVE1PjVpPkK4PVkyPDZ3PD;hQi=>
GISTT1	M3PUeWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NFe4fZU4OiCqcoO=		M2LOVmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdKW1SWMTDj[YxteyCqYYLic5JqdmdiS1nUJGQ5OT[HIH31eIFvfCCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZJIdG9iYYPzZZktKEeLNUCgQUA2Njh6IN88UU4>	NXjjSFd3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5PVE1PjVpPkK4PVkyPDZ3PD;hQi=>
HuH7	M{TY[mFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MnjjOFghcHK\|		M4nw[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSIXIO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iND63NFch\|ryPLh?=	M3X0OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEW3NFQzLz5{OUC1O\|A1OjxxYU6=
A498	NGfFU5lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NH\aOoc1QCCqcoO=		M1nDWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUS5PEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iNz65PFEh\|ryPLh?=	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTB3N{C0Nkc,OjlyNUewOFI9N2F-
NCI-H727	M1\2NmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NFnzOYY1QCCqcoO=		NWHzbXNKSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDd{NzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTBwMUKg{txONg>?	NEeyTlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC1O\|A1Oid-MkmwOVcxPDJ:L3G+
MV4-11	NWLnVmZISW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MoX5O\|IhcHK\|		MUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2YND2xNUBk\WyuczDh[pRmeiB5MjDodpMh[nliQ3XscJRqfGW{LVfsc{BtfW2rbnXzZ4VvfCClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFEh\|ryPLh?=	MkTqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7M{W3O\|IoRjJ7OUO1O\|czRC:jPh?=
HuH7	M4[4cGFvfGmycn;sbYZmemG2aY\lJIF{e2G7				NVPuR\|FpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIeWg4KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNwMEOg{txONg>?	M1XMblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEW5PFA{Lz5\|MEC1PVgxOzxxYU6=
HCT116	M{TTNGFvfGmycn;sbYZmemG2aY\lJIF{e2G7				M{\TcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwNkKg{txONg>?	NW\senlYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOVk5ODNpPkOwNFU6QDB\|PD;hQi=>
SW620	MmHoRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?				MoTsRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCVV{[yNEBk\WyuczDifUBOXFRiYYPzZZktKEmFNUCgQUA3NjJ3IN88UU4>	NVrBNo9lRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOVk5ODNpPkOwNFU6QDB\|PD;hQi=>
HepG2	MVfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?				Mkj6RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKZYDHNkBk\WyuczDifUBOXFRiYYPzZZktKEmFNUCgQUA4Njd6IN88UU4>	M2jkblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEW5PFA{Lz5\|MEC1PVgxOzxxYU6=
U251	NVnNT5prTnWwY4Tpc44h[XO\|YYm=		NF;qbFk3OCCvaX7z		NV[1bpl7UW6qaXLpeIlwdiCxZjDWSWdHNWmwZIXj[YQhXkWJRmKyJIFkfGm4YYTpc44hcW5iaIXtZY4hXTJ3MTDj[YxteyCycnX0doVifGWmIH\vdkA3OCCvaX7zJIZwdGyxd3XkJIJ6KF[HR1[gZYRlcXSrb36gZY5lKG2nYYP1doVlKGGodHXyJFExKG2rboOgZpkhTUyLU1GsJGlEPTBiPTCwMlAyQDlizszNMi=>	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7OEi2PUc,OzByOUi4Olk9N2F-
SH-SY5Y	MV;GeY5kfGmxbjDhd5NigQ>?		M13afVYxKG2rboO=		NIDkbJdKdmirYnn0bY9vKG:oIGDES2YuSkJvaX7keYNm\CCSRFfGVoJmfGFiYXP0bZZifGmxbjDpckBpfW2jbjDTTE1UYTW\IHPlcIx{KHC{ZYTy[YF1\WRiZn;yJFYxKG2rboOg[o9tdG:5ZXSgZpkhWESJRj3CRkBi\GSrdHnvckBidmRibXXhd5Vz\WRiYX\0[ZIhOTBibXnud{BjgSCHTFnTRUwhUUN3MDC9JFAvODh\|MTFOwG0v	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7OEi2PUc,OzByOUi4Olk9N2F-
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NMC-G1	NXvBN2xHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXm3SYRDUUN3ME2yO{4yQDJ{IN88US=>	M2jhWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NCI-H446	Mkn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHu3RmRKSzVyPUK3MlQ6PDZizszN	M1TK[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NB7	NYrTbJRYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXnJR\|UxRTJ5LkmyNlkh\|ryP	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
A388	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFTBUY1KSzVyPUK4MlAxPzRizszN	M1mxUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
JVM-2	NXnFb5d{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkTHTWM2OD1{OD6yPFk5KM7:TR?=	NGPRWYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
HT-144	M2DvVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVLsZnFRUUN3ME2yPE43QSEQvF2=	M3zZeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NCI-H747	M1LEOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnLOTWM2OD1{OD65NVk2KM7:TR?=	NV3VUllmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-H1650	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEXhSoNKSzVyPUK5MlAyPzZizszN	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
EB-3	NYnEVZU4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUPJR\|UxRTJ7LkWzNFkh\|ryP	M37WTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
KLE	NYrQNGJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGS2UZFKSzVyPUK5MlYyQSEQvF2=	M1PB[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
TK10	NGf2bWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1rFSGlEPTB;M{CuNVI3KM7:TR?=	NF;3T5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
COLO-668	NGfnV25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1HmUGlEPTB;M{CuO\|kzKM7:TR?=	M{XZcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NCI-H23	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUfJR\|UxRTNzLkGwOlMh\|ryP	MoX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
GOTO	NHnK[JZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXPVNFhNUUN3ME2zNU43ODh3IN88US=>	NGTqRlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
MSTO-211H	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGHVZ3pKSzVyPUOxMlg3PzhizszN	NHPiU2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
LB831-BLC	M4f2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVHJR\|UxRTN{LkO4OFMh\|ryP	NUjtRZVqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
SCH	NIXqeVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkG1TWM2OD1\|Mj64OFg2KM7:TR?=	MkT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
EHEB	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M13H[GlEPTB;M{SuNVE6OyEQvF2=	NXvGOHBbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
U-266	MmjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVzWZ5J6UUN3ME2zOE4zPzhzIN88US=>	NWTkPGdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
EW-11	Mn7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnjsTWM2OD1\|ND60O\|I2KM7:TR?=	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
TE-9	MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlTmTWM2OD1\|Nz6wOFAyKM7:TR?=	NFrqT5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
ES3	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlnkTWM2OD1\|Nz61NFA1KM7:TR?=	M1TzNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NCI-H2141	MlHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHLRbVRKSzVyPUO4MlA5PDNizszN	MlvSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
MPP-89	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3nLb2lEPTB;NEKuNFU5PiEQvF2=	NWTTeJdvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
SK-MEL-2	Ml7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlXrTWM2OD12Mj62OFA2KM7:TR?=	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
LC-1F	M3nsW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHTJTYxKSzVyPUSzMlM3QDJizszN	NHu1XYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
NH-12	Mof1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{\vPGlEPTB;NEOuPVM2QSEQvF2=	M3rDO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
RKO	MkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHuxOnhKSzVyPUS0MlEzPTJizszN	NHHiUXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
KM-H2	M4jXOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUHJR\|UxRTR2Lkm1O\|ch\|ryP	NYXNRWdHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
SK-UT-1	Ml\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYfLNIlnUUN3ME20PU45QDJ3IN88US=>	NUK5W3JqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-AKT / AKT / p-ERK / ERK; PubMed: 24759734 PLoS One Effect of 72 h treatment with sunitinib on SH-SY5Y, SK N BE(2), SK-N-AS and IMR-32 NB cell lines analyzed by Western blot with pSer473Akt, Akt, pThr202/Thr204 Erk1/2 and Erk1/2 antibodies. β-actin was used as a loading control. p-GSK3β / GSK3β / MYCN ; PubMed: 24759734 PLoS One Effect of sunitinib on GSK3β phosphorylation and on MYCN total protein in MYCN amplified NB cell lines. p-STAT3 / STAT3 / p-Src / Src / p-AKT / AKT / p-ERK / ERK ; PubMed: 19244102 Cancer Res Sunitinib reduced Stat3 and Src activity, with no dramatic reduction of AKT, MAPK and JAK signaling in 786-O cells. Tumor cells were treated with sunitinib at indicated concentrations for 2 h (left panels) or 24 h (right panels). Total cell lysates were prepared and western blots were performed using relevant antibodies to detect total protein levels, with β-actin used as the loading control.	24759734 19244102
Growth inhibition assay	Cell viability; PubMed: 24369536 Biomed Res Int Isolated effects of sunitinib malate on urinary bladder-cancer cell lines viability, assessed by using the MTT assay. The data shown and bars represent the mean values ± SD (SD: standard deviation). *P < 0.05 versus untreated cells.	24369536

In vivo

Consistent with the substantial and selective inhibition of VEGFR2 or PDGFR phosphorylation and signaling in vivo, Sunitinib (20-80 mg/kg/day) exhibits broad and potent dose-dependent anti-tumor activity against a variety of tumor xenograft models including HT-29, A431, Colo205, H-460, SF763T, C6, A375, or MDA-MB-435. Sunitinib dosing at 80 mg/kg/day for 21 days leads to complete tumor regression in six of eight mice, without tumor re-growing during a 110-day observation period after the end of treatment. Second round of treatment with Sunitinib remains efficacious against tumors that are not fully regressed during the first round of treatment. Sunitinib treatment results in significant decrease in tumor MVD, with ~40% reduction in SF763T glioma tumors. SU11248 treatment results in a complete inhibition of additional tumor growth of luciferase-expressing PC-3M xenografts, despite no reduction in tumor size. ^[2] Sunitinib treatment (20 mg/kg/day) dramatically suppresses the growth subcutaneous MV4;11 (FLT3-ITD) xenografts and prolongs survival in the FLT3-ITD bone marrow engraftment model. ^[3]

Protocol

Kinase Assay: ^[1]	- Collapse Biochemical Tyrosine Kinase Assays: IC50 values for Sunitinib against VEGFR2 (Flk-1) and PDGFRβ are determined using glutathione S-transferasefusion proteins containing the complete cytoplasmic domain of the RTK. Biochemical tyrosine kinase assays to quantitate the trans-phosphorylation activity of VEGFR2 (Flk-1) and PDGFRβ are performed in 96-well microtiter plates precoated (20 μg/well in PBS; incubated overnight at 4 °C) with the peptide substrate poly-Glu,Tyr (4:1). Excess protein binding sites are blocked with the addition of 1-5% (w/v) BSA in PBS. Purified GST-fusion proteins are produced in baculovirus-infected insect cells. GST-VEGFR2 and GST-PDGFRβ are then added to the microtiter wells in 2 × concentration kinase dilution buffer consisting of 100 mM HEPES, 50 mM NaCl, 40 μM NaVO₄, and 0.02% (w/v) BSA. The final enzyme concentration for GST-VEGFR2 or GST-PDGFRβ is 50 ng/mL. Twenty-five μL of diluted Sunitinib are subsequently added to each reaction well to produce a range of inhibitor concentrations appropriate for each enzyme. The kinase reaction is initiated by the addition of different concentrations of ATP in a solution of MnCl₂ so that the final ATP concentrations spanned the Km for the enzyme, and the final concentration of MnCl₂ is 10 mM. The plates are incubated for 5-15 minutes at room temperature before stopping the reaction with the addition of EDTA. The plates are then washed three times with TBST. Rabbit polyclonal antiphosphotyrosine antisera are added to the wells at a 1:10,000 dilution in TBST containing 0.5% (w/v) BSA, 0.025% (w/v) nonfat dry milk, and 100 μM NaVO₄ and incubated for 1 hour at 37 °C. The plates are then washed three times with TBST, followed by the addition of goat antirabbit antisera conjugated with horseradish peroxidase (1:10,000 dilution in TBST). The plates are incubated for 1 hour at 37 °C and then washed three times with TBST. The amount of phosphotyrosine in each well is quantitated after the addition of 2,2′-azino-di-[3-ethylbenzthiazoline sulfonate] as substrate.
Cell Research: ^[3]	- Collapse Cell lines: RS4;11, MV4;11, and OC1-AML5 Concentrations: Dissolved in DMSO, final concentrations ~10 μM Incubation Time: 24 and 48 hours Method: Cells are starved overnight in medium containing 0.1% FBS prior to addition of Sunitinib and FL (50 ng/mL; FLT3-WT cells only). Proliferation is measured after 48 hours of culture using the Alamar Blue assay or trypan blue cell viability assays. Apoptosis is measured 24 hours after Sunitinib addition by Western blotting to detect cleavage of poly (ADP-ribose) polymerase (PARP) or levels of caspase-3. (Only for Reference)
Animal Research: ^[2]	- Collapse Animal Models: Female nu/nu mice implanted s.c. with HT-29, A431, Colo205, H-460, SF763T, C6, A375, or MDA-MB-435, and male nu/nu mice bearing luciferase-expressing PC-3M tumors Dosages: ~80 mg/kg Administration: Orally once daily (Only for Reference)

References

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Solubility (25°C)

In vitro	DMSO	15 mg/mL (28.16 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 4% DMSO+30% PEG 300+ddH2O For best results, use promptly after mixing.	2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Sunitinib Malate SDF

Molecular Weight	532.56
Formula	C₂₂H₂₇FN₄O₂.C₄H₆O₅
CAS No.	341031-54-7
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	SU 11248 Malate
Smiles	CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O

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Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04669366	Not yet recruiting	Drug: sunitinib\|Drug: axitinib	Kidney Neoplasms	Pfizer	December 15 2020	--
NCT04633122	Recruiting	Drug: Ripretinib\|Drug: Sunitinib	Gastrointestinal Stromal Tumor(GIST)	Zai Lab (Shanghai) Co. Ltd.	November 25 2020	Phase 2
NCT04115189	Active not recruiting	Drug: Sunitinib	Metastatic Renal Cell Carcinoma ( mRCC)	Pfizer	December 13 2019	--
NCT03916458	Completed	--	Carcinoma Renal Cell	Pfizer	December 17 2019	--
NCT04033991	Active not recruiting	Drug: Sunitinib\|Drug: Axitinib	Carcinoma\|Renal Cell	Pfizer	September 27 2019	--
NCT03900793	Recruiting	Drug: Losartan\|Drug: Sunitinib	Osteosarcoma	University of Colorado Denver\|National Cancer Institute (NCI)	August 22 2019	Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
I was wondering that the compound is in its cis or trans form?
Answer:
S1042 Sunitinib Malate is Z form.
Question 2:
What is the difference between Sunitinib Malate(S1042) and Sunitinib(S7781)?
Answer:
S1042 is the Malate salt form of Sunitinib. The biological activities of these two compounds are the same but the solubility of these two compounds in aqueous solvent are different.

PDGFR Signaling Pathway Map

PDGFR Inhibitors with Unique Features

Selective VEGFR Inhibitors

Vandetanib (ZD6474) : VEGFR2-selective, IC50=40 nM.
Most Potent VEGFR Inhibitor

Cabozantinib (XL184, BMS-907351) : VEGFR2, IC50=0.035 nM.
FDA-approved VEGFR Inhibitor

Axitinib : Approved by FDA for Renal Cell Carcinoma.
Classic VEGFR Inhibitor

Nintedanib (BIBF 1120) : Potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. Phase 3.

Related PDGFR Products

AZD2932 ^New

AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively.
Sunitinib ^New

Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.
Erlotinib ^New

Erlotinib (CP358774, NSC 718781, OSI-774) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.
CP-673451

CP-673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM in cell-free assays, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity.
Imatinib (STI571)

Imatinib (STI571, CGP057148B, Gleevec) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib (STI571) induces autophagy.
PP121

PP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM.
Crenolanib (CP-868596)

Crenolanib (CP-868596, ARO 002) is a potent and selective inhibitor of PDGFRα/β with K_d of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.
Tyrphostin AG 1296

Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. Tyrphostin AG1296 inhibits FGFR and c-Kit with IC50 of 12.3 μM and 1.8 μM in Swiss 3T3 cells. Tyrphostin AG1296 induces dramatic apoptosis in A375R cells.
Sennoside B

Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
Gefitinib (ZD1839)

Gefitinib (ZD-1839, Iressa) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway.

Features:A potent EGFR tyrosine kinase inhibitor.

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Sunitinib Malate