Sunitinib (SU11248) malate

For research use only.

Licensed by Pfizer Catalog No.S1042

115 publications

Sunitinib (SU11248) malate Chemical Structure

CAS No. 341031-54-7

Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 191 In stock
USD 77 In stock
USD 107 In stock
USD 147 In stock
USD 257 In stock
USD 447 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Sunitinib (SU11248) malate has been cited by 115 publications

Purity & Quality Control

Choose Selective PDGFR Inhibitors

Biological Activity

Description Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.
Targets
IRE1α [7]
()
Kit [1]
(Cell-free assay)
FLT3 [1]
(Cell-free assay)
PDGFRβ [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
2 nM 80 nM
In vitro

Sunitinib also potently inhibits Kit and FLT-3. [1] Sunitinib is a potent ATP-competitive inhibitor of VEGFR2 (Flk1) and PDGFRβ with Ki of 9 nM and 8 nM, respectively, displaying >10-fold higher selectivity for VEGFR2 and PDGFR than FGFR-1, EGFR, Cdk2, Met, IGFR-1, Abl, and src. In serum-starved NIH-3T3 cells expressing VEGFR2 or PDGFRβ, Sunitinib inhibits VEGF-dependent VEGFR2 phosphorylation and PDGF-dependent PDGFRβ phosphorylation with IC50 of 10 nM and 10 nM, respectively. Sunitinib inhibits VEGF-induced proliferation of serum-starved HUVECs with IC50 of 40 nM, and inhibits PDGF-induced proliferation of NIH-3T3 cells overexpressing PDGFRβ or PDGFRα with IC50 of 39 nM and 69 nM, respectively. [2] Sunitinib inhibits phosphorylation of wild-type FLT3, FLT3-ITD, and FLT3-Asp835 with IC50 of 250 nM, 50 nM, and 30 nM, respectively. Sunitinib inhibits the proliferation of MV4;11 and OC1-AML5 cells with IC50 of 8 nM and 14 nM, respectively, and induces apoptosis in a dose-dependent manner. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
3T3 NFLhS5lMcW6jc3WgRZN{[Xl? Mn;2TY5pcWKrdHnvckBw\iCSRFfGMYlv\HWlZXSgRpJlXSCrbnPvdpBwemG2aX;uJJdqfGhiSVO1NEBw\iByLkCwO{DPxE1? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ2NkCxPUc,OTJ4NE[wNVk9N2F-
3T3 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;kV4hKdmirYnn0bY9vKG:oIGDsZZRmdGW2LXTldol3\WRiZ4Lve5RpKG[jY4TvdkBqdmS3Y3XkJFNVOyClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODFizszN MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ2NkCxPUc,OTJ4NE[wNVk9N2F-
3T3 MlLySpVv[3Srb36gRZN{[Xl? NF;xPIxKdmirYnn0bY9vKG:oIG\hd4N2dGG{IHXu[I91cGWuaXHsJIdzd3e2aDDmZYN1d3JicnXj[ZB1d3Jid3n0bEBKSzVyIH;mJFAvODVizszN NHvSV3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[0OlAyQSd-MUK2OFYxOTl:L3G+
3T3 M12yV2tqdmG|ZTDBd5NigQ>? Mlm3NlAhdWmw M3P3PWROW09? M3z5XmNmdGy3bHHyJIlvcGmkaYTpc44hd2ZiVlXHSkBqdmS3Y3XkJIh2dWGwIFvEVkBxcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEKyJO69VQ>? NV31SHllRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[xOlIxODhpPkG2NVYzODB6PD;hQi=>
NIH3T3 NIjSfHhMcW6jc3WgRZN{[Xl? M136XVIxKG2rbh?= MVnEUXNQ MX7pcohq[mm2IHj1cYFvKEuGUjDrbY5ie2ViZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAxNjBzODFOwG0> MlH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZzNkKwNFgoRjF4MU[yNFA5RC:jPh?=
A549 MWnGeY5kfGmxbjDBd5NigQ>? MY\EUXNQ NGLhTmVKdmirYnn0bY9vKG:oIHOtUYV1KGSncHXu[IVvfCCKR1[tbY5lfWOnZDDoeY1idiCDNUS5JINmdGxibXnndoF1cW:wIIfpeIghUUN3MDDv[kAzKM7:TR?= MnHSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2M{SxOFUoRjF6NEO0NVQ2RC:jPh?=
DU145 M4LhSmZ2dmO2aX;uJGF{e2G7 MlPNSG1UVw>? M1TQOWlvcGmkaYTpc44hd2ZiYz3N[ZQh\GWyZX7k[Y51KEiJRj3pcoR2[2WmIHj1cYFvKESXMUS1JINmdGxic3PheJRmemmwZzD3bZRpKEmFNUCgc4YhOTBizszN NV[1PHdPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0N|QyPDVpPkG4OFM1OTR3PD;hQi=>
KB3-1 Mo\SR5l1d3SxeHnjJGF{e2G7 MVS3NkBp MXzEUXNQ MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQMYdxNW6nZ3H0bZZmKEuELUOtNUBk\WyuczD3bZRpKEmFNUCgc4YhOi5|IN88US=> MmrIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|OUezNlIoRjF7M{m3N|IzRC:jPh?=
KBV1 NV3qc2RES3m2b4TvfIlkKEG|c3H5 MYG3NkBp NYjWc5Y1TE2VTx?= NI\SeI1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRNWeueXPvdJJwfGWrbj3lfJBz\XO|aX7nJGtDXjFiY3XscJMhf2m2aDDJR|UxKG:oIESuNUDPxE1? M2PCU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m3N|IzLz5zOUO5O|MzOjxxYU6=
A375 MYHDfZRwfG:6aXOgRZN{[Xl? M1T1R|czKGh? MofXSG1UVw>? MkLSTWM2OD13LkSg{txO MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ3NESwPEc,OTl4NUS0NFg9N2F-
RS4-11 NV7DcHdCTnWwY4Tpc44hSXO|YYm= NUf3Tm9sOiCq M2fpT2lvcGmkaYTpc44hd2ZiRlzUN{BifXSxcHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxQTlizszN MorzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4NUS0NFgoRjF7NkW0OFA5RC:jPh?=
RS4-11 MUfGeY5kfGmxbjDBd5NigQ>? MViyJIg> NF;aO41KdmirYnn0bY9vKG:oIF\MWFMhUVSGIH31eIFvfCCjdYTvdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjB|NDFOwG0> NVHrOXVbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm2OVQ1ODhpPkG5OlU1PDB6PD;hQi=>
Sf9 NV\6RWRwU2mwYYPlJGF{e2G7 MUOzNEBucW5? M1uwbWlvcGmkaYTpc44hd2ZiR2PUMZRi\2enZDDWSWdHWiCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFAvOTh3IN88US=> MofYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6NUSwOVEoRjF7OEW0NFUyRC:jPh?=
Ba/F3 NUfaTFV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XzfVczKGh? NF;1b4pKSzVyPUGuNkDPxE1? NXfp[|cxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNVcxODRpPkKwNVE4ODB2PD;hQi=>
BaPTC2 MlTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:5XVczKGh? MlPuTWM2OD1yLkKyJO69VQ>? NXy4R|RZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNVcxODRpPkKwNVE4ODB2PD;hQi=>
Sf9 NFX4NZZHfW6ldHnvckBCe3OjeR?= NGOzS2kyKGh? MkOxSG1UVw>? MWfJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEircz30ZYdo\WRiUlXUJIV5eHKnc4Pl[EB4cXSqIFnDOVAhd2ZiMT6zJO69VQ>? MmXuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMUewNFQoRjJyMUG3NFA1RC:jPh?=
H4 MUjDfZRwfG:6aXOgRZN{[Xl? M2jCVFExKM7:TR?= M3fNTXRwgGmlaYT5JIlvKGi3bXHuJGg1KGOnbHzz NX3BV2dDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA5ODZpPkKwN|UxQDB4PD;hQi=>
SF-539 NV;tXphqU2mwYYPlJGF{e2G7 M3\MSFM{OyEQvF2= NWnmWGxbPjBibXnu MmP6SG1UVw>? NV\zbVNsUW6qaXLpeIlwdiCxZjDQSGdHWmKndHGgdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAyOi5{IN88US=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODRyM{ewNEc,OjB2MEO3NFA9N2F-
U251 NH3t[WxMcW6jc3WgRZN{[Xl? NXzmeohSOzN|IN88US=> NYrnd5RnPjBibXnu MVvEUXNQ MoK3TY5pcWKrdHnvckBw\iCYRVfGVlIheGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iBzOD65JO69VQ>? NEDtO2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MESwN|cxOCd-MkC0NFM4ODB:L3G+
A431 M2rKPWtqdmG|ZTDBd5NigQ>? M2DoU2lvcGmkaYTpc44hd2ZiUFTHSnJj\XSjIHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOTJwMjFOwG0> M2POcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUW4NFczLz5{MEW1PFA4OjxxYU6=
A431 NXzVW2p1U2mwYYPlJGF{e2G7 MVfJcohq[mm2aX;uJI9nKF[HR1\SNkBmgHC{ZYPz[YQhf2m2aDDJR|UxKG:oIEG4Mlkh|ryP MofJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3NUiwO|IoRjJyNUW4NFczRC:jPh?=
HepG2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXPUVVkPzJiaB?= NEG0cYdKSzVyPUOuPFEh|ryP NXu0OVk2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1O|A2OjZpPkKwOVcxPTJ4PD;hQi=>
Kasumi-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PTd|czKGh? MVXJR|UxRTBwMEG2JO69VQ>? M{PPclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUewOVI3Lz5{MEW3NFUzPjxxYU6=
RS4-11 NWDSNoxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVS3NkBp NET3WlRKSzVyPUGg{txO NVXqNZZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1O|A2OjZpPkKwOVcxPTJ4PD;hQi=>
THP1 MoqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrNS|VLPzJiaB?= NYC3cJA5UUN3ME2wMlUh|ryP MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODV5MEWyOkc,OjB3N{C1NlY9N2F-
Kasumi-1 MYLGeY5kfGmxbjDBd5NigQ>? M1PHNmlvcGmkaYTpc44hd2ZiYz3LbZQh[XW2b4Doc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4xOTVizszN NXHzNpFmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4N|MxOzlpPkKwPFM{ODN7PD;hQi=>
A549 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HNb|E3KGh? M{nReGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIO= NYrxfmVuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ|PD;hQi=>
HL60 M4TCbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnyWWcyPiCq NH\EPGlCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzz NWnId|NPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ|PD;hQi=>
HUVEC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvlXIluOTZiaB?= M3XSZmlvcGmkaYTpc44hd2ZiVlXHSk1qdmS3Y3XkJINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiMj63OUDPxE1? NVTOVlhlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ|PD;hQi=>
HUVEC NGfnTYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYSxOkBp NIjTd|VKdmirYnn0bY9vKG:oIHLGS2YucW6mdXPl[EBk\WyuIIDyc4xq\mW{YYTpc44hf2m2aDDJR|UxKG:oIESuNFQh|ryP NVq2NHAyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ|PD;hQi=>
IM9 NIrFcGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4SyNFE3KGh? M2Xu[GFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFnNPUBk\Wyucx?= Mn7lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUC0OlMoRjJzNEWwOFY{RC:jPh?=
K562 NI[3ZVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fXWVE3KGh? NXzFWYN7SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsdy=> NEHmPXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS1NFQ3Oyd-MkG0OVA1PjN:L3G+
MDA-MB-231 NFuyV4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX4WZcyPiCq MkPyRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[Yxtew>? NF;FbYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS1NFQ3Oyd-MkG0OVA1PjN:L3G+
H460 MnzjR5l1d3SxeHnjJGF{e2G7 NX\SR3p6PzJiaB?= M3HsTWlEPTB;Mj63JO69VQ>? M4PCVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkKxPFgxLz5{MU[yNVg5ODxxYU6=
SMMC7721 NITrflFEgXSxdH;4bYMhSXO|YYm= MUS3NkBp M1H3NWlEPTB;Nj60O{DPxE1? NYXRVopoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2NlE5QDBpPkKxOlIyQDhyPD;hQi=>
WI38 M4jxNmN6fG:2b4jpZ{BCe3OjeR?= NEj0enk4OiCq M{D6TWlEPTB;OD61OkDPxE1? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ{MUi4NEc,OjF4MkG4PFA9N2F-
HEK293 Ml:zT4lv[XOnIFHzd4F6 M{HhO|ExOCCwTR?= MnTLNUBp MknM[I9meyCwb4SgbY5pcWKrdDDWSWdHNWmwZIXj[YQh[XW2b4Doc5NxcG:{eXzheIlwdiCxZjD0fZJwe2mwZTCxNVc2KHKnc3nkeYUhd25iVlXHSnIzKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJM> Mli3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6OEWyPFcoRjJzOEi1Nlg4RC:jPh?=
HUVEC MX3GeY5kfGmxbjDBd5NigQ>? NVuxRolJOSEQvF2= Ml7CNlQhcA>? M3O1RWFvfGmjbnfpc4dmdmmlIHHjeIl3cXS7IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKF[HR1[tbY5lfWOnZDDj[YxtKG2rZ4LheIlwdg>? MlPpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkOzNFUoRjJzOU[zN|A2RC:jPh?=
HUVEC NYHydlFJTnWwY4Tpc44hSXO|YYm= MmK4NUDPxE1? NHfLNoEyKGh? MV7Jcohq[mm2aX;uJI9nKEWUSzDwbI9{eGixconsZZRqd25iYYSgWIhzOjB{L2T5dlIxPCCrbjDWSWdHNXO2aX31cIF1\WRiSGXWSWM> NHzldHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2N|MxPSd-MkG5OlM{ODV:L3G+
HUVEC NF;o[lFHfW6ldHnvckBCe3OjeR?= MnfsNUDPxE1? M3jSUlEhcA>? NGjHXmVKdmirYnn0bY9vKG:oIHXOU3MheGixc4Doc5J6dGG2aX;uJIF1KFOncj2xNVczKGmwIG\FS2Yue3SrbYXsZZRm\CCKVW\FRy=> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4M{OwOUc,OjF7NkOzNFU9N2F-
HUVEC MkjFT4lv[XOnIFHzd4F6 NIXZ[28yKM7:TR?= MXuxJIg> M3TRXWlvcGmkaYTpc44hd2ZiVlXHSnIzKHCqb4PwbI9zgWyjdHnvckBifCC2eYKtNVE4PSCrbjDWSWdHNXO2aX31cIF1\WRiSGXWSWM> M4LaTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[zN|A2Lz5{MUm2N|MxPTxxYU6=
HUVEC MkDnSpVv[3Srb36gRZN{[Xl? Mo\MNUDPxE1? MlfwNUBp Ml22[I9meyCwb4SgbY5pcWKrdDDBT3QheGixc4Doc5J6dGG2aX;uJIF1KFOncj20O|MhcW5iVlXHSk1{fGmvdXzheIVlKEiXVlXD NI\ye289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2N|MxPSd-MkG5OlM{ODV:L3G+
HL60 MV;DfZRwfG:6aXOgRZN{[Xl? MXq1NEDPxE1? MlHuOFghcA>? Mme3SG1UVw>? NH;MUYJKSzVyPUG1MlUh|ryP NXHnepNuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNVkyQDhpPkKyNFE6OTh6PD;hQi=>
K562 MUfDfZRwfG:6aXOgRZN{[Xl? MWK1NEDPxE1? NGLCcIY1QCCq NVzR[HAxTE2VTx?= MVvJR|UxRTJzLkmg{txO NWLROnNvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNVkyQDhpPkKyNFE6OTh6PD;hQi=>
PC3 NWHiXo9FS3m2b4TvfIlkKEG|c3H5 MU[1NEDPxE1? MXO0PEBp MYPEUXNQ MmLETWM2OD1{NT6xJO69VQ>? MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjBzOUG4PEc,OjJyMUmxPFg9N2F-
SF-539 NFPWb25McW6jc3WgRZN{[Xl? MYWzN|Mh|ryP NIDEOW83OCCvaX6= MmP5TY5pcWKrdHnvckBw\iCSRFfGVoJmfGFidInyc5NqdmVia3nuZZNmKGGldHn2bZR6KGmwIGDES2YuSkJvc4TpcZVt[XSnZDDoeY1idiCVRj21N|kh[2WubIOge4l1cCCLQ{WwJI9nKDF{LkKg{txO NELweJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKwOFc1OSd-MkKyNFQ4PDF:L3G+
HAEC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLaNVAxKM7:TR?= M{Hne|czKGh? Mmn1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQVXDJINmdGy|IHX4dJJme3OrbnegWmVITlJid3n0bEBKSzVyIH;mJFAvOSEQvF2= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR2NE[3PUc,OjJ2NES2O|k9N2F-
HT-29 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfEe20yODBizszN MlTWO|IhcA>? M1S1eWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOg[ZhxemW|c3nu[{BXTUeIUjD3bZRpKEmFNUCgc4YhOC5|MzFOwG0> M1LhR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NES0Olc6Lz5{MkS0OFY4QTxxYU6=
MV4-11 NFjacWtEgXSxdH;4bYMhSXO|YYm= MVK3NkBp NHnI[5RKSzVyPUCuNFA{KM7:TR?= Ml;OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NUK1NVgoRjJ{NEWyOVE5RC:jPh?=
HepG2 M{PlfGN6fG:2b4jpZ{BCe3OjeR?= M2PQUFQ5KGh? NE\wUFNKSzVyPUGzMlI1KM7:TR?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR6M{[wPEc,OjJ2OEO2NFg9N2F-
PC9 MXTDfZRwfG:6aXOgRZN{[Xl? NFHpV4Y1QCCq NE\iVm5KSzVyPUGwMlk4KM7:TR?= NV3tbYRHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFM3ODhpPkKyOFg{PjB6PD;hQi=>
CAKI-1 NHzCUWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPwNVAxKM7:TR?= Mn7jOFghcA>? NH;4OJRFVVOR NXjX[Gd4T0l3ME2wMlY{KM7:TR?= NXvEe2NqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OlA3OjdpPkKyOVYxPjJ5PD;hQi=>
EKVX M{\mNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXSxNFAh|ryP MmLVOFghcA>? NHTBXGlFVVOR M{X4R2dKPTB;Nz65JO69VQ>? MoPvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3NkC2NlcoRjJ{NU[wOlI4RC:jPh?=
MCF7 MlHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVWxNFAh|ryP NHj6TI01QCCq NUDmW4k6TE2VTx?= MWLHTVUyRTJizszN NU\EOZNLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OlA3OjdpPkKyOVYxPjJ5PD;hQi=>
MDA-MB-435 NHWxWIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HzN|ExOCEQvF2= MmLmOFghcA>? MWPEUXNQ NIrjdVZIUTV{PUKg{txO NHvJelg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
OVCAR3 NFjGT5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYWxNFAh|ryP MYS0PEBp NFPvdoNFVVOR NUTZW29CT0l3M{2zMlIh|ryP MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
SNB19 M4njXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnGR|R7OTByIN88US=> NF7ESII1QCCq M2XX[mROW09? NIjNenRIUTV2PUGwJO69VQ>? M3LMR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NU[wOlI4Lz5{MkW2NFYzPzxxYU6=
SW620 Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4n0OVExOCEQvF2= Mn3LOFghcA>? NV7GT3B{TE2VTx?= MWHHTVU2RTFwMzFOwG0> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
TK10 NGX2UWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\UNVAxKM7:TR?= MXW0PEBp MmXjSG1UVw>? M3jFTmdKPTZ;Nj6zJO69VQ>? NH;SOIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
UACC257 NGT3XohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXKxNFAh|ryP MonGOFghcA>? NYrSc2ZUTE2VTx?= NXnBV3ZvT0l3N{20JO69VQ>? NEXndZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
HAEC NYrRd|ZUS3m2b4TvfIlkKEG|c3H5 M4PWVFExOCEQvF2= MnzmO|IhcA>? MonySG1UVw>? M{\wdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KF[HR1\SJIV5eHKnc4PpcochUEGHQzD3bZRpKEmFNUCgc4YhOC5zIN88US=> MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF|MUW0NUc,OjNzM{G1OFE9N2F-
HT-29 MVjDfZRwfG:6aXOgRZN{[Xl? MkXFNVAxKM7:TR?= NG\TfW04OiCq MlfVSG1UVw>? NEL6NJREgXSxdH;4bYNqfHliYXfhbY5{fCCYRVfGVkBmgHC{ZYPzbY5oKGi3bXHuJGhVNTJ7IHPlcIx{KHerdHigTWM2OCCxZjCwMlM{KM7:TR?= Mn3JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzM{G1OFEoRjJ|MUOxOVQyRC:jPh?=
HCT116 MVHGeY5kfGmxbjDBd5NigQ>? M3j6NFI1KGh? M1nlcWROW09? MWHBcpRqdWmpcnH0c5J6KGGldHn2bZR6KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDtbYdz[XSrb36= MmnMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNUOyNFAoRjJ|MUWzNlAxRC:jPh?=
HUVEC NVj2[VJKTnWwY4Tpc44hSXO|YYm= M2nBbVIh|ryP MVixPEBp NW\rOYI4TE2VTx?= NViwSFJsSW62aXHu[4lw\2WwaXOgZYN1cX[rdImgbY4hUFWYRVPzJJVv\GW{IHj5dI95cWNiY3;u[Il1cW:wIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidIXi[UBnd3KvYYTpc44> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF3M{KwNEc,OjNzNUOyNFA9N2F-
ACHN NF7ze|REgXSxdH;4bYMhSXO|YYm= NGHpUlM3KGR? MmTPTWM2OD1{LkWg{txO NXmyfYF1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzOlAyODRpPkKzN|YxOTB2PD;hQi=>
A498 Mmr2R5l1d3SxeHnjJGF{e2G7 MlLaNVAxKM7:TR?= M4L3Z|czKGh? NGXaNVFFVVOR MUDJR|UxRTRwMzFOwG0> NWDNWmloRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PFk3OjZpPkKzOFg6PjJ4PD;hQi=>
HUVEC M2f6N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzRN{DPxE1? M1ruRlI1KGh? NFntbnNFVVOR NVLENmpjSW62aXHu[4lw\2WwaXOgZYN1cX[rdImgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDWSWdHNWmwZIXj[YQhfHWkZTDmc5Ju[XSrb36ge4l1cCCHQ{WwJI9nKDBwNkS1JO69VQ>? NF;1fJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W4N|kyOSd-MkO1PFM6OTF:L3G+
HUVEC MlPKT4lv[XOnIFHzd4F6 MoLONlAxKM7:TR?= NXP3XotETE2VTx?= MUXJcohq[mm2aX;uJI9nKF[HR1\SNkBxcG:|cHjvdplt[XSrb36gbY4h\3Kxd4ToJIZi[3Sxcj3zeIlufWyjdHXkJGhWXkWF MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV6M{mxNUc,OjN3OEO5NVE9N2F-
HUVEC NH\hNXdMcW6jc3WgRZN{[Xl? Mn;ENlAxKM7:TR?= NV;OS4RxTE2VTx?= MV\Jcohq[mm2aX;uJI9nKF[HR1\SNUBxcG:|cHjvdplt[XSrb36gbY4h\3Kxd4ToJIZi[3Sxcj3zeIlufWyjdHXkJGhWXkWF NFexd4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W4N|kyOSd-MkO1PFM6OTF:L3G+
A549 M2T0d2N6fG:2b4jpZ{BCe3OjeR?= M{PhelczKGh? NIjle4tFVVOR NGLtcoZKSzVyPUKuOFQh|ryP NVHOdFJWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NFI1PDFpPkKzOlAzPDRzPD;hQi=>
HCT116 MljhR5l1d3SxeHnjJGF{e2G7 MY[3NkBp NI\FNHdFVVOR MXfJR|UxRTRwN{Gg{txO MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMkS0NUc,OjN4MEK0OFE9N2F-
MCF7 M4L4PGN6fG:2b4jpZ{BCe3OjeR?= M{\UUlczKGh? NWK5N4tUTE2VTx?= MXTJR|UxRTZwMkmg{txO MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMkS0NUc,OjN4MEK0OFE9N2F-
BGC NVewTmdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3oO|IhcA>? NG\t[VZFVVOR MVPJR|UxRTRwN{ig{txO NHLtUlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1OCd-MkO5PVkxPDB:L3G+
BxPC3 NIHwSlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrGUJpuPzJiaB?= Mn\vSG1UVw>? MYDJR|UxRTNwNkOg{txO MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl7OUC0NEc,OjN7OUmwOFA9N2F-
HT-29 NWTjNWJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYm3NkBp NX7pO|ZVTE2VTx?= M{HTSmlEPTB;MT60O{DPxE1? Ml20QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7OUmwOFAoRjJ|OUm5NFQxRC:jPh?=
T24 M2C2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzZO|IhcA>? NGLkWI1FVVOR NF[w[HBKSzVyPUKuOFQh|ryP MlH3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7OUmwOFAoRjJ|OUm5NFQxRC:jPh?=
4T1 NVLi[IxXS3m2b4TvfIlkKEG|c3H5 MVG3NkBp NH;EUm5FVVOR M2TOT2lEPTB;MD6wNVYh|ryP NFfoRYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MCF7 NUjUemxnS3m2b4TvfIlkKEG|c3H5 NW\CcY5QPzJiaB?= NWmxVWVITE2VTx?= M{\YeGlEPTB;MD6wNlcyKM7:TR?= Mn7lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
MCF7 MXHDfZRwfG:6aXOgRZN{[Xl? NELnemo4OiCq MVXEUXNQ NGXNeZlKSzVyPUCuNFI6OyEQvF2= NIHDZpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MDA-MB-231 MlvYR5l1d3SxeHnjJGF{e2G7 M4HzXVczKGh? MWTEUXNQ MlexTWM2OD1yLkCyNlMh|ryP M4XncVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
MDA-MB-435 NVHSeZhHS3m2b4TvfIlkKEG|c3H5 MXW3NkBp NGDOWINFVVOR NFPnbXZKSzVyPUCuNFA6PyEQvF2= Ml\QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
MDA-MB-468 NEXKb3VEgXSxdH;4bYMhSXO|YYm= MWO3NkBp NFjT[HFFVVOR NWfmRZhGUUN3ME2wMlAxPjFizszN M33Bc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
A431 NWHqTIdRU2mwYYPlJGF{e2G7 NXXtOHp3OTBizszN MVSxJIg> M3rKOmROW09? M2D2WmlvcGmkaYTpc44hd2ZiRVfGVkB4cXSqIFnDOVAhd2ZiMD6xO|IyKM7:TR?= M1PKWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
SH-SY5Y MVTLbY5ie2ViQYPzZZk> NUHMPFdFOTBizszN Mlj2NUBp NFT1VHpFVVOR MmrZTY5pcWKrdHnvckBw\iCSRFfGVoJmfGFid3n0bEBKSzVyIH;mJFAvODh|MTFOwG0> MmXNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
U251 NGXV[JpMcW6jc3WgRZN{[Xl? NEPvdXIyOCEQvF2= MnyyNUBp NF61R2dFVVOR NFHzUnRKdmirYnn0bY9vKG:oIG\FS2ZTOiC5aYToJGlEPTBib3[gNE4xOTh7IN88US=> MkjTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
Bel7402 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLzO|IhcA>? NHn5N4dFVVOR MorSTWM2OD1{Lk[3JO69VQ>? M{jXSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
HK2 MmX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzHXog4OiCq Mlu5SG1UVw>? NFzZT2JKSzVyPUWuPFUh|ryP MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2NUc,OjR7MES5OlE9N2F-
LO2 NXjRUm5NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXryOWE{PzJiaB?= M{O0Z2ROW09? Mn72TWM2OD1zOT65N{DPxE1? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2NUc,OjR7MES5OlE9N2F-
MV4-11 M{fI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnZOFghcA>? NWXBcW44TE2VTx?= NGPrWJhKSzVyPUCuNFA{KM7:TR?= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2NUc,OjR7MES5OlE9N2F-
NCI-H3122 M1z3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFznb5A4OiCq MljtSG1UVw>? NWjMTppnUUN3ME2wMlg{KM7:TR?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2NUc,OjR7MES5OlE9N2F-
NCI-H460 NYfySHZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXq3NkBp Ml;QSG1UVw>? MV\JR|UxRTRwM{Gg{txO M1i1ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
NCI-H526 NGfrV2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlf2O|IhcA>? NGTlRZlFVVOR NXzZfmRCUUN3ME2xMlAyKM7:TR?= M3vOeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
TT NWHMRopET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUS3NkBp M2r6SGROW09? M1[2W2lEPTB;MD6wOEDPxE1? NWXZO|JURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFQ6PjFpPkK0PVA1QTZzPD;hQi=>
3T3 M3f5XGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHryVIE4OiCqcoO= NHvuSINCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIEPUN{Bk\WyuczDlfJBz\XO|aX7nJIh2dWGwIFPTSlFTKGGodHXyJFczKGi{czDifUBE\WyudHn0[ZIh[XO|YYmsJGFkfGm4aYT5JF0hOC5yOTFOwG0v MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ7NE[0NUc,OTh4OUS2OFE9N2F-
MV4-11 NIflOodCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NUDwe2cyPzJiaILz MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2YND2xNUBk\WyuczDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6wNFQ{KM7:TT6= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd3NEG5PUc,OTl5NUSxPVk9N2F-
HEK293 NGjy[3dHfW6ldHnvckBie3OjeR?= NXPpZ3hiSmmwZHnu[{Bi\m[rbnn0fUB1dyCITGSzJINifGGueYTpZ{Bld22jaX6g[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBkd22yZYTpeIl3\SCkaX7kbY5oKGG|c3H5MEBM\CB;IECuNFAxPDdizszNMi=> M3HHS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{W0NVk6Lz5zOUe1OFE6QTxxYU6=
FDC-P1 Mnm0SpVv[3Srb36gZZN{[Xl? MXq0PEBpenN? NF3rU3hKdmirYnn0bY9vKG:oIHj1cYFvKE[PUzDlfJBz\XO|ZXSgbY4h\3Kxd4ToJIZi[3SxcjDk[ZBmdmSnboSgcY92e2ViRlTDMXAyKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gSm1UNW2nZHnheIVlKGOnbHygdJJwdGmoZYLheIlwdiCrbjDwdoV{\W6lZTDoeY1idiCFU1[xJIFnfGW{IES4JIhzeyCkeTDy[ZNignW{aX6g[JlmKHKnZIXjeIlwdiCjc4PhfUwhUUN3MDC9JFAvOTV3IN88UU4> NHPsOGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG1OlY5QSd-MkCxOVY3QDl:L3G+
primary leukemia cells MmXER5l1d3SxeHnjbZR6KGG|c3H5 MYm3NkBpenN? NIPLXZNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBxemmvYYL5JIxmfWunbXnhJINmdGy|IHnzc4xifGWmIH\yc40h[WO3dHWgcZlmdG:rZDDs[ZVs\W2rYTDwZZRq\W62IHX4dJJme3OrbnegSmxVOy2LVFSgcZV1[XSrb36gZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IHz1Z4ln\XKjc3WgZZN{[XluIFnDOVAhRSByLkCzJO69VS5? NIjGSIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
primary leukemia cells NHPpcWpEgXSxdH;4bYNqfHliYYPzZZk> M{W2cFczKGi{cx?= Mm\6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdJJqdWG{eTDs[ZVs\W2rYTDj[YxteyCrc3;sZZRm\CCocn;tJIFkfXSnIH35[YxwcWRibHX1b4VucWFicHH0bYVvfCCneIDy[ZN{cW6pIIfpcIQhfHmyZTDGUHQ{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBtfWOrZnXyZZNmKGG|c3H5MEBKSzVyIE2gNE4xOyEQvF2u M1:zfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkKxNlAyLz5{MkKyNVIxOTxxYU6=
primary leukemia cells NV7hSHZlS3m2b4TvfIlkcXS7IHHzd4F6 MVi3NkBpenN? M4ThOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJBzcW2jcomgcIV2c2WvaXGgZ4VtdHNiaYPvcIF1\WRiZoLvcUBi[3W2ZTDtfYVtd2mmIHzleYtmdWmjIIDheIlmdnRiZYjwdoV{e2mwZzDGUHQ{NUR6M{XZJI12fGG2aX;uJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDseYNq\mW{YYPlJIF{e2G7LDDJR|UxKD1iMT6xJO69VS5? MljXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MkGyNFEoRjJ{MkKxNlAyRC:jPh?=
endothelial precursor cells Mn3nSpVv[3Srb36gZZN{[Xl? MWXJcohq[mm2aX;uJI9nKGWwZH;0bIVtcWGuIHPvdoQh[XKnYTDmc5Ju[XSrb36gbY4h\W6mb4To[Yxq[WxicILlZ5Vze2:{IHPlcIx{KGK7IFPEN|Eh[2:{ZDDhdoViKGSndHXjeIlwdiCkYYPl[EBxcGWwb4T5dIlkKGS{dXeg[Il{[2:4ZYL5JIJie2WmIHHzd4F6NCCLQ{WwJF0hOC5yMEm2JO69VS5? M{fQelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEC5OlY3Lz5{MkSwPVY3PjxxYU6=
endothelial precursor cells NYLTUmhTTnWwY4Tpc44h[XO|YYm= NEDKcVNKdmirYnn0bY9vKG:oIHPlcIwhdWmpcnH0bY9vKGmwIHXu[I91cGWuaXHsJJBz\WO3coPvdkBk\WyuczDifUBQemm|IHPlcIwhdWmpcnH0bY9vKGurdDDiZZNm\CCyaHXuc5R6eGmlIHTyeYch\Gm|Y3;2[ZJ6KGKjc3XkJIF{e2G7LDDJR|UxKD1iMUOuOkDPxE1w MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjRyOU[2Okc,OjJ2MEm2OlY9N2F-
U251 NVH5PVl5TnWwY4Tpc44h[XO|YYm= NVrlOGFTPjBibXnudy=> Mn3oTY5pcWKrdHnvckBw\iCYRVfGVlIhcW5iaIXtZY4hXTJ3MTDj[YxteyCycnX0doVifGWmIH\vdkA3OCCvaX7zJI1m[XO3cnXkJIFnfGW{IEGgbJIh[nliRVzJV2EtKEmFNUCgQUAyQC57IN88UU4> NUL5XJBtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3N|kxQTBpPkKyO|M6ODlyPD;hQi=>
U251 NFXlRVVHfW6ldHnvckBie3OjeR?= NVvoUYYzPjBibXnudy=> MoHhTY5pcWKrdHnvckBw\iCYRVfGMYlv\HWlZXSgWmVITlJ{IIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCXMkWxJINmdGy|IH;2[ZJmgHC{ZYPzbY5oKE[uaz2xJJBz\XS{ZXH0[YQh\m:{IE[wJI1qdnNicILpc5IhfG9iVlXHSkBi\GSrdHnvckBu\WG|dYLl[EBi\nSncjCxNEBucW6|IHL5JJBpd3OyaH;0fZJwe2mwZTDFUGlUSSCleYTvZoxwfCCjbnHsfZNqeyxiSVO1NEA:KDF6Lkmg{txONg>? NGrmZVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O3OVA6OCd-MkOzO|UxQTB:L3G+
U251 NHKzXIVHfW6ldHnvckBie3OjeR?= MlvpOlAhdWmwcx?= NXrVbXhkUW6qaXLpeIlwdiCxZjDWSWdHWjJiaX6gbJVu[W5iVUK1NUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIG\FS2YucW6mdXPl[EB1gXKxc3nu[UBxcG:|cHjvdplt[XSrb36gbY5kfWKjdHXkJIZweiB4MDDtbY5{KHC{aX;yJJRwKF[HR1[tZYN1cX[jdHnvckBu\WG|dYLl[EAyOCCvaX7zJIJ6KEWOSWPBMEBKSzVyIE2gNVgvQSEQvF2u NWjue3ZmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0N|QyOzlpPkKzOFM1OTN7PD;hQi=>
CHO MkWySpVv[3Srb36gZZN{[Xl? MUPJcohq[mm2aX;uJI9nKEOjdkGuNkBkfXK{ZX70JI1m[XO3cnXkJJV{cW6pIGHQZZRkcCCjdYTvcYF1cWNicHH0bEBkdGGvcDDzfZN1\W1iaX6gR2hQKGOnbHzzJIV5eHKnc4PpcochS2G4MT6yMEBj\XSjLUKgZY5lKGGucHjhMVIw\GWudHGtNUB{fWK3bnn0d{whUUN3MDC9JFM{NjRizszNMi=> NH:4Spo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ixNlUxOyd-MkO4NVI2ODN:L3G+
U251 NIrNU3VHfW6ldHnvckBie3OjeR?= NXXqVVV2UW6qaXLpeIlwdiCxZjDWSWdHWjJiaX6gbJVu[W5iVUK1NUBk\WyuczDifUBxcG:|cHjveJlzd3OrbnWgSWxKW0FuIFnDOVAhRSByLkCxPFkh|ryPLh?= NEnXbGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFg3PSd-MkS5NFA5PjV:L3G+
MCF7 NUXaTpJRSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M4PxUVQ5KGi{cx?= MmLORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD61JO69VS5? NHvWUpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC2OFM1Pyd-MkWwOlQ{PDd:L3G+
HepG2 MX\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NHXpZ4I1QCCqcoO= M1O1bmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGzMlYh|ryPLh?= M1XJPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3ME[0N|Q4Lz5{NUC2OFM1PzxxYU6=
CHO NUfVO4tSTnWwY4Tpc44h[XO|YYm= NXLReZBCUW6qaXLpeIlwdiCxZjDyZZBq\CCmZXzhfYVlKGmwd3Hy[EBz\WO2aX\5bY5oKHCxdHHzd4l2dSCldYLy[Y51KCiLS4KpJIlvKEOqaX7ld4UhcGGvc4TldkBwfmG{eTCoR2hQMSClZXzsd{B{fGGkbHWg[ZhxemW|c3nu[{BpTVKJIH3lZZN2emWmIIXzbY5oKEmxbmfvdot{KEKjcoLhZ5Vl[SCjdYTvcYF1\WRicHH0Z4gh[2yjbYCgdIxifG[xcn2sJGlEPTBiPTC3Mlk1OzJ6IN88UU4> MkT5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEe3OVMoRjJ3MEi3O|U{RC:jPh?=
CHO K1 NWTyT|g1TnWwY4Tpc44h[XO|YYm= NGrZRWVKdmirYnn0bY9vKG:oIILhdIllKGSnbHH5[YQhcW65YYLkJJJm[3SrZonpcocheG:2YYPzbZVuKGO3coLlcpQhMEmNcjmgbY4hS2irbnXz[UBp[W2|dHXyJI93[XK7IDjDTG8qKEtzIHPlcIx{KHO2YXLsfUBmgHC{ZYPzbY5oKGiHUlegcYVie3W{ZXSgeZNqdmdiSX;uW49zc3NiUYXheJRzdyCjdYTvcYF1\WRicHH0Z4gh[2yjbYCgdIxifG[xcn2sJGlEPTBiPTCxNEDPxE1w NHvufWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4O|c2Oyd-MkWwPFc4PTN:L3G+
CHO K1 MVjGeY5kfGmxbjDhd5NigQ>? NYnjUJM5UW6qaXLpeIlwdiCxZjDmZZN1KHOxZHn1cUBkfXK{ZX70JEhKVmFrIHnuJGNpcW6nc3WgTIFue3SncjDPeoFzgSBqQ1jPLUBMOSClZXzsd{B1emGwc3\lZ5Rm\CC5aYToJIh2dWGwIF7helEvPSCvZXHzeZJm\CC3c3nu[{BKd26Zb4Lrd{BSfWG2dILvJIF2fG:vYYTl[EBx[XSlaDDjcIFueCCybHH0[o9zdSxiSVO1NEA:KDF3Lki0PFkh|ryPLh?= MmfkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEe3OVMoRjJ3MEi3O|U{RC:jPh?=
HEK293 NH61WG5HfW6ldHnvckBie3OjeR?= NVy3eGs1UW6qaXLpeIlwdiCxZjDmZZN1KHOxZHn1cUBkfXK{ZX70JEhKVmFrIHnuJGhGUzJ7MzDj[YxteyC2cnHud4Zm[3SnZDD3bZRpKGi3bXHuJG5ifjFwNTDt[YF{fXKnZDD1d4lv\yCLb37Xc5JseyCTdXH0eJJwKGG3dH;tZZRm\CCyYYTjbEBkdGGvcDDwcIF1\m:{bTygTWM2OCB;IEO5MlgyODdizszNMi=> NWD4N5ExRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPFc4PTNpPkK1NFg4PzV|PD;hQi=>
MOLM13 M1\CUWN6fG:2b4jpZ4l1gSCjc4PhfS=> M{LRXFQ5KGi{cx?= M4OzbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1QVE1zMzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMUe3JO69VS5? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB6OUixNEc,OjVyOEm4NVA9N2F-
MV4-11 NEDae2dEgXSxdH;4bYNqfHliYYPzZZk> MXi0PEBpenN? MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODJ2MzFOwG0v NGDi[Fc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4PVgyOCd-MkWwPFk5OTB:L3G+
HL60 MnHQR5l1d3SxeHnjbZR6KGG|c3H5 M3LNWlQ5KGi{cx?= MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlA{PjhizszNMi=> NXu0eIxKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPFk5OTBpPkK1NFg6QDFyPD;hQi=>
THP1 MUHDfZRwfG:6aXPpeJkh[XO|YYm= MnzqOFghcHK| NYXLPHpRS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXEiSMTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yNEW3JO69VS5? MkHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEm4NVAoRjJ3MEi5PFExRC:jPh?=
ACHN NEK3cIVEgXSxdH;4bYNqfHliYYPzZZk> Mmf1O|IhcHK| M3LpSGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGFEUE5iY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIh|ryPLh?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTF{NEGxOEc,OjVzMkSxNVQ9N2F-
U251 MUXGeY5kfGmxbjDhd5NigQ>? M{HXUFYxKG2rbh?= NY\Rblk6UW6qaXLpeIlwdiCxZjDWSWdHWjJiaX6gbJVu[W5iVUK1NUBk\WyuczDjc41xd3WwZDDwdoV1emWjdHXkJIZweiB4MDDtbY4h[mWob4LlJHZGT0Zic4TpcZVt[XSrb36g[o9zKDFyIH3pcpMh[nlicHjvd5Bpd3S7cn;zbY5mKEWOSWPBJIN6fG:kbH;0JI1mfGixZDygTWM2OCB;IECuNFE5QSEQvF2u MnXjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6OEK1NVkoRjJ3OEiyOVE6RC:jPh?=
U251 Mn\iSpVv[3Srb36gZZN{[Xl? MnrvOlAhdWmw M{CwUmlvcGmkaYTpc44hd2ZiUFTHSnIu[mW2YTDpckBpfW2jbjDVNlUyKGOnbHzzJINwdXCxdX7kJJBz\XS{ZXH0[YQh\m:{IE[wJI1qdiCkZX\vdoUhWESJRj3CRkB{fGmvdXzheIlwdiCob4KgNVAhdWmwczDifUBxcG:|cHjveJlzd3OrbnWgSWxKW0FiY4n0c4Jtd3RibXX0bI9lNCCLQ{WwJF0hOC5yOEOxJO69VS5? M1HaflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEiyOVE6Lz5{NUi4NlUyQTxxYU6=
A431 NV7PO2twTnWwY4Tpc44h[XO|YYm= NWLRNGtQPjBibXnu MlHPTY5pcWKrdHnvckBw\iCHR1\SJIlvKGi3bXHuJGE1OzFiY3XscJMh[2:vcH;1coQheHKndILlZZRm\CCob4KgOlAhdWmwIHLl[o9z\SCHR1[gd5RqdXWuYYTpc44h\m:{IEGwJI1qdnNiYomgdIhwe3Cqb4T5do9{cW6nIFXMTXNCKGO7dH;icI91KG2ndHjv[EwhUUN3MDC9JFAvOTd{MTFOwG0v Mn\wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6OEK1NVkoRjJ3OEiyOVE6RC:jPh?=
HT-29 MWLDfZRwfG:6aXPpeJkh[XO|YYm= NFXHWnM1QCCqcoO= MlLhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iND63JO69VS5? NVLWbmloRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wNFkyPjRpPkK2NFA6OTZ2PD;hQi=>
A549 Mn7tR5l1d3SxeHnjbZR6KGG|c3H5 NVjzUGh2PDhiaILz NIHETZhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEeuPVMh|ryPLh?= NH\0XVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwPVE3PCd-Mk[wNFkyPjR:L3G+
SKOV3 MXjDfZRwfG:6aXPpeJkh[XO|YYm= M{\Bd|Q5KGi{cx?= NFXtWVlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTC5MlIyKM7:TT6= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByOUG2OEc,OjZyMEmxOlQ9N2F-
PANC1 Mlf6R5l1d3SxeHnjbZR6KGG|c3H5 Mm[3OFghcHK| NXvkXGNUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEGQQ{GgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNVQvQTRizszNMi=> NF7NTpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwPVE3PCd-Mk[wNFkyPjR:L3G+
HepG2 NHL1eHdEgXSxdH;4bYNqfHliYYPzZZk> MXm0PEBpenN? MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSBzNj6wOkDPxE1w MoS2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEmxOlQoRjJ4MEC5NVY1RC:jPh?=
MCF7 MX;DfZRwfG:6aXPpeJkh[XO|YYm= Ml\VOFghcHK| MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDJ3LkSxJO69VS5? NXPwUmkyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wNFkyPjRpPkK2NFA6OTZ2PD;hQi=>
Bel7402 MUnQbI91d2O7dH;0c5hq[2m2eTDhd5NigQ>? MlzUOUBpenN? Mk\UVIhwfG:leYTveI95cWOrdImgZYdicW6|dDDoeY1idiCEZXy3OFAzKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JJBz\WmwY4XiZZRm\CCob4KgOUBpenNid3n0bEBk\WyuczDmc4xtd3enZDDifUBWXkFvMTDpdpJi\GmjdHnvckBifCB|LkCgcXcw[21pMjDmc5IhOjBibXnud{Bu\WG|dYLl[EBi\nSncjC0PEBpenNiYomgR2NMQCCjc4PhfUwhTUN3MDC9JFEyKM7:TT6= NGn2fpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW4OFA5PSd-Mk[1PFQxQDV:L3G+
PANC1 NXzl[4RjWGixdH;jfZRwfG:6aXPpeJkh[XO|YYm= M4fuVVUhcHK| NIHkVWZRcG:2b3P5eI91d3irY3n0fUBi\2GrboP0JIh2dWGwIGDBUmMyKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JJBz\WmwY4XiZZRm\CCob4KgOUBpenNid3n0bEBk\WyuczDmc4xtd3enZDDifUBWXkFvMTDpdpJi\GmjdHnvckBifCB|LkCgcXcw[21pMjDmc5IhOjBibXnud{Bu\WG|dYLl[EBi\nSncjC0PEBpenNiYomgR2NMQCCjc4PhfUwhTUN3MDC9JFE{KM7:TT6= MnHyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OESwPFUoRjJ4NUi0NFg2RC:jPh?=
SVEC4-10 NF7QWlFEgXSxdH;4bYNqfHliYYPzZZk> NGrT[mczPCCqcoO= NUjST3RMS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhW1[HQ{StNVAh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IEig{txONg>? NHfNXJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkmxNlEyOSd-Mk[5NVIyOTF:L3G+
HUVEC NIfIUXhCdnSrYX7nbY9o\W6rYzDhd5NigQ>? MkPFNVAhfU1? MoLsOUBpenN? M363TWFvfGmjbnfpc4dmdmmlIHHjeIl3cXS7IHnuJIh2dWGwIFjVWmVEKGOnbHzzJIF{e2W|c3XkJIF{KGGwZ3nv[4Vv\XOrczDyZZRmKGG2IEGwJJVOKGGodHXyJFUhcHK|IHL5JIVv\G:2aHXsbYFtKHS3YnWg[o9zdWG2aX;uJIF{e2G7IILlcIF1cX[nIITvJINwdnS{b3y= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjlzMkGxNUc,OjZ7MUKxNVE9N2F-
HT-29 NWDReJJES3m2b4TvfIlkcXS7IHHzd4F6 NWLLN3BDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU44KM7:TT6= M1HKV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUKwPFAxLz5{NkmyNFgxODxxYU6=
A549 NHzWTYNEgXSxdH;4bYNqfHliYYPzZZk> M3jjdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOT6xJO69VS5? M4izRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUKwPFAxLz5{NkmyNFgxODxxYU6=
MDA-MB-435 M{DKXGN6fG:2b4jpZ4l1gSCjc4PhfS=> M3LQPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20N|Uh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS5|IN88UU4> NYD3XYVsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5NlA5ODBpPkK2PVIxQDByPD;hQi=>
MV4-11 MofvRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NFnXZZo4OiCqcoO= MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IF\MWFMuUVSGIHTldIVv\GWwdDDoeY1idiCPVkStNVEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCwMlAxOSEQvF2u MmGwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
HL60 NWnqbVZZSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NIf1R444OiCqcoO= M2PifmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNFAyKM7:TT6= MoPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
BAF3 M4ryZWZ2dmO2aX;uJIF{e2G7 MXW3NkBpenN? M3LsWmlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhXDZ5MFmgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8wS0ONODDhd5NigSxiR1m1NEA:KDBwMECyJO69VS5? NIT6NpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
MOLM14 NWjldIlpSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M4S4ZVczKGi{cx?= NUHGTmZmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBHVFR|LVnUSEBl\XCnbnTlcpQhcHWvYX6gUW9NVTF2IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5yMEWg{txONg>? NEfXcoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
BAF3 MkDmSpVv[3Srb36gZZN{[Xl? NUHTUZRsPzJiaILz MYjJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJHY2PTmGL2[2OVRCKGSxdXLs[UBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ|IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFYh|ryPLh?= NF;HVYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
BAF3 NEfwe5NHfW6ldHnvckBie3OjeR?= NHO5XWc4OiCqcoO= M2HIOWlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhXjV3OVSgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8wS0ONODDhd5NigSxiR1m1NEA:KDBwMEC5JO69VS5? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BAF3 M4XwcWZ2dmO2aX;uJIF{e2G7 MlzsO|IhcHK| Mmr3TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBXPjV2QTDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W|ZTDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5yMjFOwG0v NInueHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
BAF3 MmjrSpVv[3Srb36gZZN{[Xl? M2HEZVczKGi{cx?= MnfZTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBNPTZ5UDDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W|ZTDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5yMkOg{txONg>? NYLuR2FTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|c4ODVpPkK3NFc4PzB3PD;hQi=>
GISTT1 MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MUK3NkBpenN? M{m5WmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgZ2tKXCCmZYDlcoRmdnRiaIXtZY4hT0mVVGSxJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6wOFEh|ryPLh?= NF7xNpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
BAF3 NVLIb4c2TnWwY4Tpc44h[XO|YYm= MXO3NkBpenN? Mn3nTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBVPjdyST;WOVU6TCCmb4XicIUhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgO|IhcHK|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNFU{KM7:TT6= M2\YbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
BAF3 M16xTmZ2dmO2aX;uJIF{e2G7 M{XzW|czKGi{cx?= NE\YdldKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjT2lVKCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFAvODd6IN88UU4> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
GIST882 NVPRVXBkSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MYO3NkBpenN? NIXRXpdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JINMUVRiZHXw[Y5l\W62IHj1cYFvKEeLU2S4PFIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCwMlEyKM7:TT6= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BAF3 NY\hNXVwTnWwY4Tpc44h[XO|YYm= NVPZSW5RPzJiaILz NVvNVo11UW6qaXLpeIlwdiCxZjDU[Ywu\nW|ZXSgZ2tKXCCQOEKyT{BufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ|IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD61NUDPxE1w MoTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
Rec1 NHThZlNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWnlR4gzPzJiaILz MonDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCUZXOxJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD64O{DPxE1w NFXzS2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
K562 NFOzRmVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MV63NkBpenN? NFPGb2NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGJEWi2DQlyg[IVx\W6mZX70JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCxJO69VS5? M2Hj[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
KU812 NV2zVXRmSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M2H2dlczKGi{cx?= MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFLDVk1CSkxiZHXw[Y5l\W62IHj1cYFvKEuXOEGyJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMT6xJO69VS5? M2PBd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
BCR-ABL dependent MEG01 MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NGfFOFg4OiCqcoO= M2\JV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQlPSMWFDVCCmZYDlcoRmdnRiTVXHNFEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCxMlIh|ryPLh?= NXLEPVNuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|c4ODVpPkK3NFc4PzB3PD;hQi=>
BAF3 M4e3TWZ2dmO2aX;uJIF{e2G7 NIXrdpQ4OiCqcoO= NXjqNFl2UW6qaXLpeIlwdiCxZjDU[Ywu\nW|ZXSgZ2tKXCCGOEG2WkBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ|IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMT6zPEDPxE1w MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
U937 NH\rcIxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mmn1O|IhcHK| MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV7M{egZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwN0OFS{igZZN{[XluIFfJOVAhRSBzLkeg{txONg>? NXPUNpcyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|c4ODVpPkK3NFc4PzB3PD;hQi=>
GIST48B MXvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MV:3NkBpenN? MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeLU2S0PGIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCyMlAyKM7:TT6= NWDOPXlPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|c4ODVpPkK3NFc4PzB3PD;hQi=>
CHO NIPGZVdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M{XuXFczKGi{cx?= MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFPIU{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IEKuNFMh|ryPLh?= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
CHL M2D2c2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1vwRVczKGi{cx?= NEnLcmRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGNJVCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFIvPDhizszNMi=> M4L3[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
BAF3 MYXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MoLZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEQV[zJINmdGy|LDDHTVUxKD1iMj63PEDPxE1w MmTEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
MDA-MB-231 NWfNSoR{S3m2b4TvfIlkcXS7IHHzd4F6 M3[wV|Q5KGi{cx?= NHfPfJlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC3MlQh|ryPLh?= NU\nSFB4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexNlgyPzNpPkK3NVI5OTd|PD;hQi=>
BT549 NEHvZ4JEgXSxdH;4bYNqfHliYYPzZZk> NH62b441QCCqcoO= NVfJTlFpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSlR3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3LkWg{txONg>? M4DwSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVc{Lz5{N{GyPFE4OzxxYU6=
DU145 MV;DfZRwfG:6aXPpeJkh[XO|YYm= M2PFT|Q5KGi{cx?= MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVYvPCEQvF2u NH7tOHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GyPFE4Oyd-MkexNlgyPzN:L3G+
PC3 MVHDfZRwfG:6aXPpeJkh[XO|YYm= M2XNb|Q5KGi{cx?= MmPCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxPU43KM7:TT6= NG\vSYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GyPFE4Oyd-MkexNlgyPzN:L3G+
RWPE1 NV;NSGJpS3m2b4TvfIlkcXS7IHHzd4F6 NFfJWGs1QCCqcoO= M130N2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJYWEVzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOyEQvF2u M4nFV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUK4NVc{Lz5{N{GyPFE4OzxxYU6=
MCF7 MmHtSpVv[3Srb36gZZN{[Xl? NFLOWnIyKHWP MWWyOEBpenN? NVvQbnRJUW6qaXLpeIlwdiCxZjDWSWdHWjJicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGW6cILld5Nqd25ib3[gdIhwe3Cqb4L5cIF1\WRiRWLLNU8zKGG2IEGgeW0hcW6ldXLheIVlKG[xcjCyOEBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ NVjU[|lbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexO|Y6PDRpPkK3NVc3QTR2PD;hQi=>
MCF7 MYTGeY5kfGmxbjDhd5NigQ>? NXnUUWxYOSC3TR?= NIjrN5YzPCCqcoO= NHvOToFKdmirYnn0bY9vKG:oIG\FS2ZTOiCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h\XiycnXzd4lwdiCxZjDwbI9{eGixconsZZRm\CCUYX[xJIF1KDFidV2gbY5kfWKjdHXkJIZweiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz NHOwPFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G3Olk1PCd-MkexO|Y6PDR:L3G+
PA1 NHPLWmVEgXSxdH;4bYNqfHliYYPzZZk> NVT5OXQyPDhiaILz MlXOR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGEyKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA4Njl5IN88UU4> NVWwZ2VlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyNVA1OzhpPkK3NlExPDN6PD;hQi=>
LNCAP Mmf1R5l1d3SxeHnjbZR6KGG|c3H5 M4nwdlQ5KGi{cx?= MXPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMUmNCWCClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTJwNkGg{txONg>? M4ntb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MkGwOFM5Lz5{N{KxNFQ{QDxxYU6=
RWPE1 NGLpRnNEgXSxdH;4bYNqfHliYYPzZZk> NY\xWnlEPDhiaILz MlHtR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVndRTTFiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ|IN88UU4> NUf3SIpxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyNVA1OzhpPkK3NlExPDN6PD;hQi=>
MCF7 MU\DfZRwfG:6aXPpeJkh[XO|YYm= MXK0PEBpenN? NYrR[YEzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkOuO|Yh|ryPLh?= M{TxdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MkGwOFM5Lz5{N{KxNFQ{QDxxYU6=
MDA-MB-231 NVXSSHZFS3m2b4TvfIlkcXS7IHHzd4F6 MV[0PEBpenN? MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gO{41PCEQvF2u M2P5cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NES4PVE3Lz5{N{S0PFkyPjxxYU6=
A549 NHezeW5EgXSxdH;4bYNqfHliYYPzZZk> M2XS[lQ5KGi{cx?= M3yzWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzND60JO69VS5? Mn\WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2NEi5NVYoRjJ5NES4PVE3RC:jPh?=
BT549 Ml7yR5l1d3SxeHnjbZR6KGG|c3H5 NILa[Zg1QCCqcoO= MYnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCWFU1QSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3LkW0JO69VS5? M4f2PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NES4PVE3Lz5{N{S0PFkyPjxxYU6=
DU145 Mn3BR5l1d3SxeHnjbZR6KGG|c3H5 NIfLUnA1QCCqcoO= MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF4LkO4JO69VS5? NUHlS29bRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke0OFg6OTZpPkK3OFQ5QTF4PD;hQi=>
PC3 NWi0SJVCS3m2b4TvfIlkcXS7IHHzd4F6 MWm0PEBpenN? M{TMPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF7Lk[g{txONg>? NEnTe|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{S0PFkyPid-Mke0OFg6OTZ:L3G+
MCF7 M{WzOGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4HHVFQ5KGi{cx?= MmDlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ|Lkig{txONg>? NX\VblVuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke0OFg6OTZpPkK3OFQ5QTF4PD;hQi=>
MDA-MB-231 NHLI[lJEgXSxdH;4bYNqfHliYYPzZZk> NV\WSHd{PDhiaILz MlXjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5LkSg{txONg>? NF63Rmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[zPVM3QSd-Mke2N|k{Pjl:L3G+
HeLa M1\FZWN6fG:2b4jpZ4l1gSCjc4PhfS=> NGfyWno1QCCqcoO= MoPLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNE41KM7:TT6= NUTvXlVxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2N|k{PjlpPkK3OlM6OzZ7PD;hQi=>
PC3 M3zCVWN6fG:2b4jpZ4l1gSCjc4PhfS=> MVe0PEBpenN? NX3Gcog4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEzNjZizszNMi=> MlzIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4M{mzOlkoRjJ5NkO5N|Y6RC:jPh?=
A549 NHTIXlhEgXSxdH;4bYNqfHliYYPzZZk> M3rQV|Q5KGi{cx?= MkOxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOE41KM7:TT6= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ|OUO2PUc,Ojd4M{mzOlk9N2F-
BT549 MmTUR5l1d3SxeHnjbZR6KGG|c3H5 MXW0PEBpenN? MULDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCWFU1QSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOU42KM7:TT6= M1nHdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkO5N|Y6Lz5{N{[zPVM3QTxxYU6=
DU145 MVrDfZRwfG:6aXPpeJkh[XO|YYm= NEjHRnI1QCCqcoO= NWH0UYptS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTZwMzFOwG0v MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ|OUO2PUc,Ojd4M{mzOlk9N2F-
RWPE1 M1fxZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> MUi0PEBpenN? NFfkeGFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBTX1CHMTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPS5{IN88UU4> NHTYPWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[zPVM3QSd-Mke2N|k{Pjl:L3G+
L02 MVTDfZRwfG:6aXPpeJkh[XO|YYm= M{XnbFczKGi{cx?= M1XofmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGwxOiClZXzsd{Bi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUA1NjZ{IN88UU4> NYPLT3BERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2OFM3OzlpPkK3OlQ{PjN7PD;hQi=>
HL60 MlPpR5l1d3SxeHnjbZR6KGG|c3H5 M1;QWVczKGi{cx?= NYnBfIUyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB2Lkm1JO69VS5? MkPFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4NEO2N|koRjJ5NkSzOlM6RC:jPh?=
U251 NHfITHVHfW6ldHnvckBie3OjeR?= MUW2NEBucW6| MUfJcohq[mm2aX;uJI9nKF[HR1\SMVIhcW5iaIXtZY4hXTJ3MTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hXkWJRjDpcoR2[2WmIIDoc5NxcG:{eXzheIlwdiCycnXpcoN2[mG2ZXSg[o9zKDZyIH3pcpMh\m:ubH;3[YQh[nliVlXHSkBi\GSrdHnvckBu\WG|dYLl[EBi\nSncjCxNEBucW6|IHL5JGVNUVODIH3leIhw\CxiSVO1NEA:KDBwMEG4PUDPxE1w NWTORYN1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4PVQ2QDlpPkK3PFk1PTh7PD;hQi=>
SF539 M3LhTWZ2dmO2aX;uJIF{e2G7 M4nzU|YxKG2rboO= MXHJcohq[mm2aX;uJI9nKFCGR1\SMYJmfGFiaX6gbJVu[W5iU1[1N|kh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIGDES2YuSkJiaX7keYNm\CCyaH;zdIhwenmuYYTpc44heHKnaX7jeYJifGWmIH\vdkA3OCCvaX7zJIZwdGyxd3XkJIJ6KFCGR1[tRmIh[WSmaYTpc44hdWWjc4Xy[YQh[W[2ZYKgNVAhdWmwczDifUBGVEmVQTDt[ZRpd2RuIFnDOVAhRSByLkC4N|Eh|ryPLh?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzh7NEW4PUc,Ojd6OUS1PFk9N2F-
HuH7 MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2LVbFQ5KGi{cx?= NX7uNJUyT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUHWKNzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOy5yMzFOwG0v M2T4elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUW2N|Q1Lz5{N{m1OlM1PDxxYU6=
HCT116 NYHaVlB{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVq0PEBpenN? M1u2[Wdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS54MjFOwG0v MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl3NkO0OEc,Ojd7NU[zOFQ9N2F-
SW620 MnnwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mly1OFghcHK| MV\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTW|YzOCClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOk4zPSEQvF2u NUHCe3NURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OVY{PDRpPkK3PVU3OzR2PD;hQi=>
MV4-11 NITkcmlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVL3V2JKPzJiaILz M1;temFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTW[0MVEyKGOnbHzzJIhiemKxcnnu[{BHVFR|IFnUSEBufXSjboSgZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IECuNFM5PSEQvF2u M1y0fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEO4N|I5Lz5{OECzPFMzQDxxYU6=
CHO NI[1fXNHfW6ldHnvckBie3OjeR?= NXj1[FVDUW6qaXLpeIlwdiCxZjDoeY1idiCHUleg[ZhxemW|c3XkJIlvKEOKTzDj[YxteyCkeTDRdIF1[2hiYYPzZZktKEmFNUCgQUAxNjVizszNMi=> NFXad|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECzPFMzQCd-MkiwN|g{Ojh:L3G+
HepG2 MkHZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NF3CVnY1QCCqcoO= NIfpU|BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOk4xPiEQvF2u NGX0XJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC1O|QzOyd-MkiwOVc1OjN:L3G+
MCF7 NV\qbFZHSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkX0OFghcHK| NEL3[phCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK1MlQyKM7:TT6= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB3N{SyN{c,OjhyNUe0NlM9N2F-
HEK293 NXjwVGlJTnWwY4Tpc44h[XO|YYm= MmXYNkBucW6| M4[z[GlvcGmkaYTpc44hd2ZiaIXtZY4hV0OWMTDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHWydHHr[UBw\iCDU2CrJIFnfGW{IEKgcYlveyCkeTDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTBiPTC2MlEh|ryPLh?= M2PmUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkOwPVg2Lz5{OEKzNFk5PTxxYU6=
RCC4 NG\tVopCdnSrY3HuZ4VzKGG|c3H5 NWPYc2dGPDhiaILz NYC2eWQ2SW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJHJESzRiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHhVXCCjc4PhfUwhUUN3MDC9JFQh|ryPLh?= NWPZNVNiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNlU3ODBpPkK4N|I2PjByPD;hQi=>
MDA-MB-231 NFK5O2FCdnSrY3HuZ4VzKGG|c3H5 NHXZXGs1QCCqcoO= M3Lp[2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XluIFnDOVAhRSB4IN88UU4> MlfVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|MkW2NFAoRjJ6M{K1OlAxRC:jPh?=
COLO205 NF3TfZlEgXSxdH;4bYNqfHliYYPzZZk> M4O2SlI1KGi{cx?= MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDU2xQOjB3IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA5KM7:TT6= MmrSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NU[wNlQoRjJ6N{W2NFI1RC:jPh?=
K562 NYC0bW92S3m2b4TvfIlkcXS7IHHzd4F6 MUeyOEBpenN? NVTnR4NyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTRizszNMi=> MlfnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NU[wNlQoRjJ6N{W2NFI1RC:jPh?=
MDA-MB-231 MWDDfZRwfG:6aXPpeJkh[XO|YYm= M3HyXVI1KGi{cx?= M2PlbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOyJO69VS5? NXG4e3U1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVYxOjRpPkK4O|U3ODJ2PD;hQi=>
MDA-MB-231 NE\xZZNEgXSxdH;4bYNqfHliYYPzZZk> NYi4XHFoOjRiaILz MYHDfZRwfG:6aXPpeJkhcW5iaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPi57ODFOwG0v Mme5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NkCzNVMoRjJ6N{[wN|E{RC:jPh?=
MCF7 NIrqdVVHfW6ldHnvckBie3OjeR?= M{eyXVQhfU1? MXqyOEBpenN? NWHFclJVUW6qaXLpeIlwdiCxZjDWSWdHWjJicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYSgOEB2VSCrbnP1ZoF1\WRiZn;yJFI1KGi{czDifUBY\XO2ZYLuJIJtd3RibXX0bI9l MnrTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NEKxNVMoRjJ6OUSyNVE{RC:jPh?=
GISTT1 M2XFZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYe3NkBpenN? NXXtS21{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hT0mVVGSxJINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmekeubzDhd5NigSxiR1m1NEA:KDBwMESg{txONg>? NVm1VG5QRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5PVE1PjVpPkK4PVkyPDZ3PD;hQi=>
GISTT1 MYrDfZRwfG:6aXPpeJkh[XO|YYm= MljhO|IhcHK| MlznR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gS2lUXFRzIHPlcIx{KGijcnLvdolv\yCNSWSgWFY4OElibYX0ZY51KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldmdtdyCjc4PhfUwhT0l3MDC9JFAvODlizszNMi=> M3rxNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUmxOFY2Lz5{OEm5NVQ3PTxxYU6=
GIST430 NGHJVotEgXSxdH;4bYNqfHliYYPzZZk> NXXsc4o5PzJiaILz NHn0[pBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBIUVOWNEOwJINmdGy|IHjhdoJwemmwZzDLTXQhXjZ3NFGgcZV1[W62IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmekeubzDhd5NigSxiR1m1NEA:KDBwMEm4JO69VS5? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl7MUS2OUc,Ojh7OUG0OlU9N2F-
GISTT1 NIHt[3NEgXSxdH;4bYNqfHliYYPzZZk> MofiO|IhcHK| MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDHTXNVXDFiY3XscJMhcGG{Yn;ybY5oKEuLVDDEPFE3TSCvdYThcpQh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyS4xwKGG|c3H5MEBIUTVyIE2gOU45QCEQvF2u Mm\KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7OUG0OlUoRjJ6OUmxOFY2RC:jPh?=
HuH7 M4G3UmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MXO0PEBpenN? M3LvdmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSIXIO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iND63NFch|ryPLh?= NEi3UG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC1O|A1Oid-MkmwOVcxPDJ:L3G+
A498 M2TRbmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NInvdJM1QCCqcoO= Mnn5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNEm4JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5Lkm4NUDPxE1w NX;adHhJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwOVcxPDJpPkK5NFU4ODR{PD;hQi=>
NCI-H727 M{T2VmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1\wXVQ5KGi{cx?= MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3IO|I4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNE4yOiEQvF2u MlrJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyNUewOFIoRjJ7MEW3NFQzRC:jPh?=
MV4-11 NGHCeFFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFT5PJI4OiCqcoO= NYqxcYh2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNmdGy2aYTldk1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjBzIN88UU4> MnnLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7M{W3O|IoRjJ7OUO1O|czRC:jPh?=
HuH7 NVqwWmw1SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MlnrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKdVi3JINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMvODNizszNMi=> NV36S49JRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOVk5ODNpPkOwNFU6QDB|PD;hQi=>
HCT116 MVLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3j4VWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwNkKg{txONg>? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB3OUiwN{c,OzByNUm4NFM9N2F-
SW620 NGPwbZVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3fuRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2e2NlAh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPi5{NTFOwG0v MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB3OUiwN{c,OzByNUm4NFM9N2F-
HepG2 MkX4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3rMbmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPy55ODFOwG0v MkLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNUm4NFMoRjNyMEW5PFA{RC:jPh?=
U251 MWLGeY5kfGmxbjDhd5NigQ>? NFTFOmw3OCCvaX7z NVfTWGNVUW6qaXLpeIlwdiCxZjDWSWdHNWmwZIXj[YQhXkWJRmKyJIFkfGm4YYTpc44hcW5iaIXtZY4hXTJ3MTDj[YxteyCycnX0doVifGWmIH\vdkA3OCCvaX7zJIZwdGyxd3XkJIJ6KF[HR1[gZYRlcXSrb36gZY5lKG2nYYP1doVlKGGodHXyJFExKG2rboOgZpkhTUyLU1GsJGlEPTBiPTCwMlAyQDlizszNMi=> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7OEi2PUc,OzByOUi4Olk9N2F-
SH-SY5Y MXLGeY5kfGmxbjDhd5NigQ>? M3rTVlYxKG2rboO= MWDJcohq[mm2aX;uJI9nKFCGR1[tRmIucW6mdXPl[EBRTEeIUnLleIEh[WO2aY\heIlwdiCrbjDoeY1idiCVSD3TXVV[KGOnbHzzJJBz\XS{ZXH0[YQh\m:{IE[wJI1qdnNiZn;scI94\WRiYomgVGRITi2EQjDh[IRqfGmxbjDhcoQhdWWjc4Xy[YQh[W[2ZYKgNVAhdWmwczDifUBGVEmVQTygTWM2OCB;IECuNFg{OSEQvF2u NXu2co4yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVg5PjlpPkOwNFk5QDZ7PD;hQi=>
A431 MX\GeY5kfGmxbjDhd5NigQ>? NIS0ZlU3OCCvaX7z MnvjTY5pcWKrdHnvckBw\iCHR1[tbY5lfWOnZDDFS2ZTKGGldHn2ZZRqd25iaX6gbJVu[W5iQUSzNUBk\WyuczDwdoV1emWjdHXkJIZweiB4MDDtbY5{KG[xbHzve4VlKGK7IFXHSkBi\GSrdHnvckBidmRibXXhd5Vz\WRiYX\0[ZIhOTBibXnud{BjgSCHTFnTRUwhUUN3MDC9JFAvOTd{MTFOwG0v MnXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUi4OlkoRjNyMEm4PFY6RC:jPh?=
BA/F3 M4fKR2Z2dmO2aX;uJIF{e2G7 MVu3NkBpenN? MnLnTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiBzMTDk[YxmfGmxbjCoOVU4KHSxIEW1PEBz\XOrZIXld{khdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkCwOEDPxE1w NYmycpczRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3 NUS2Tld6TnWwY4Tpc44h[XO|YYm= MWS3NkBpenN? NGW3dlVKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEGxJIRmdGW2aX;uJEg2PTdidH:gOVU5KHKnc3nkeYV{MSCjbnSgSFgyPkhibYX0ZY51KGGwZDDUOlcxUSCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IECuNFA2KM7:TT6= NVPsfHdVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3 M4rkb2Z2dmO2aX;uJIF{e2G7 NVq1fFNsPzJiaILz NGPib5hKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEGxJIRmdGW2aX;uJEg2PTdidH:gOVU5KHKnc3nkeYV{MSCjbnSgWlY2PEFibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGdKPTBiPTCwMlAxPiEQvF2u NHTLc2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3 MUHGeY5kfGmxbjDhd5NigQ>? NV7n[GJvPzJiaILz MX3Jcohq[mm2aX;uJI9nKEurdDDlfI9vKDliQWm1NFIhfG9iNUCzJIlve2W{dHnvckBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMEC3JO69VS5? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3 M1rxOmZ2dmO2aX;uJIF{e2G7 MWm3NkBpenN? MnLyTY5pcWKrdHnvckBw\iCNaYSgWlU3OERxVk[1OGEhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkCwO{DPxE1w MlfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3 M{L1O2Z2dmO2aX;uJIF{e2G7 MX23NkBpenN? MUjJcohq[mm2aX;uJI9nKEurdDDlfI9vKDliQWm1NFIhfG9iNUCzJIlve2W{dHnvckBidmRiVk[1OEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMEGyJO69VS5? MnLZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3 MYfGeY5kfGmxbjDhd5NigQ>? NVfkeWpXPzJiaILz MXrJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OlAhfG9iNUe4JJJme2mmdXXzLUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMEK0JO69VS5? M1THclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
BA/F3 M4\USGZ2dmO2aX;uJIF{e2G7 MYm3NkBpenN? MYTJcohq[mm2aX;uJI9nKEurdDDWOVYxTCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IECuNFI4KM7:TT6= NHX4cWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3 MX7GeY5kfGmxbjDhd5NigQ>? NVS3O5g3PzJiaILz NUDudYxqUW6qaXLpeIlwdiCxZjDUSWwu\nW|ZXSgVGRITlKjbIDoZUApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD6wN{DPxE1w MnjZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3 MVjGeY5kfGmxbjDhd5NigQ>? Mn\aO|IhcHK| NFW0c5NKdmirYnn0bY9vKG:oIFvEVkApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD6wN|Mh|ryPLh?= NFToRm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3 MWnGeY5kfGmxbjDhd5NigQ>? M2rrV|czKGi{cx?= NIPZU|FKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDQSGdHWmKndHGgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMUG0JO69VS5? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3 MoPTSpVv[3Srb36gZZN{[Xl? M{XrdlczKGi{cx?= MVjJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBidmRiREiyNGEhdXW2YX70JIFv\CCGOEKwRUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMkG0JO69VS5? MkLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3 MnfSSpVv[3Srb36gZZN{[Xl? MWe3NkBpenN? MULJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBidmRiTkiyNmshdXW2YX70JIFv\CC\OEKzSEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMkexJO69VS5? MnPxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3 MULGeY5kfGmxbjDhd5NigQ>? NHjkNVE4OiCqcoO= NWrKbnc3UW6qaXLpeIlwdiCxZjDLbZQh\XixbjCxNUBl\WyndHnvckApPTV5IITvJFU2QCC{ZYPp[JVmeyliYX7kJGQ5OT[KIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCpcn;3eIghcW6ldXLheIVlKG[xcjC3NkBpenNiYomgUXRUKGG|c3H5MEBIUTVyIE2gNE4{QThizszNMi=> NYDCN4hwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3 M1Pj[WZ2dmO2aX;uJIF{e2G7 MV[3NkBpenN? M4HDXmlvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW|aXT1[ZMqKGGwZDDBPFI6WCCvdYThcpQh[W6mIGm4NlNFKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD60N{DPxE1w NXvLSZRJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3 M1v1ZmZ2dmO2aX;uJIF{e2G7 MlTQO|IhcHK| NHn4VI1KdmirYnn0bY9vKG:oIFvpeEBmgG:wIEmgRXk2ODJidH:gOVA{KGmwc3XyeIlwdiCjbnSgSFgyPiCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IECuOVg1KM7:TT6= M{HmblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
BA/F3 NFjUTYxHfW6ldHnvckBie3OjeR?= M2S5UlczKGi{cx?= MYXJcohq[mm2aX;uJI9nKFCGR1\SZYxxcGFiVkW2NWQwTDh2Mm[gcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEeLNUCgQUAxNjZ|MTFOwG0v NETYTFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3 M33kbWZ2dmO2aX;uJIF{e2G7 MYK3NkBpenN? NGnwendKdmirYnn0bY9vKG:oIFvpeEBFQDF4VjDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VWyCjc4PhfUwhT0l3MDC9JFAvPjN6IN88UU4> NF\WUZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3 M1ezUmZ2dmO2aX;uJIF{e2G7 NXP2cXR6PzJiaILz M{\LWGlvcGmkaYTpc44hd2ZiS3n0JHY2PjCGL1S4NVZJKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD62PVYh|ryPLh?= NFTTS5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3 NX7pU5R[TnWwY4Tpc44h[XO|YYm= M3[z[|czKGi{cx?= MnjPTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiBzMTDk[YxmfGmxbjCoOVU4KHSxIEW1PEBz\XOrZIXld{kh[W6mIGm4NlNFKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD63PFIh|ryPLh?= MoLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3 NH\BVHBEgXSxdH;4bYNqfHliYYPzZZk> M4PwZVczKGi{cx?= MWLDfZRwfG:6aXPpeJkhcW5ibX;1d4UheGG{ZX70ZYwhSkFxRkOgZ4VtdHNiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwJF0hPC55OEmg{txONg>? M3LlUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
Sf21 M{XLUmZ2dmO2aX;uJIF{e2G7 M1u5d|YxKG2rboO= MnjWTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCQLYTldo1qdmGuIFjpd|YufGGpZ3XkJGtFWiBqN{mwJJRwKGWwZDDy[ZNq\HWnczmg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIGPmNlEhcW6|ZXP0JINmdGy|IHHmeIVzKDZyIH3pcpMh[nliRVzJV2EtKEmFNUCgQUAxNjByNEeg{txONg>? MlPMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{NEGwNVAoRjNyMkSxNFExRC:jPh?=
EoL-1-cell MmXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEe2RZdKSzVyPUGuOlQheE1? M4S3W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
MV-4-11 Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDqbZpKSzVyPUK3NkBxVQ>? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
NOS-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7obWtKSzVyPUG1MlMhdk1? NWPsc4RwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
CGTH-W-1 NY\IOGZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXlTWM2OD1|MD65OEBvVQ>? MnqxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
MONO-MAC-6 NGTtNlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTN|Lkigcm0> MnTTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
ALL-PO MknYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7ETWM2OD15OT64PUBvVQ>? NXXFfmZMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NKM-1 NYTkSoZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\iOWE1UUN3ME25PE42OiCwTR?= Mln2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
KM12 M{nCTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTQRW5KSzVyPUO1NE4yPCCwTR?= M{Lo[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
TE-15 MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTVyNz62NUBvVQ>? M{DIeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
697 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTZzND6yOUBvVQ>? NG\vPVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
MOLT-16 Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTZ|MT6zNkBvVQ>? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
GB-1 NFzwNIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXnboxKSzVyPUexNE4zOyCwTR?= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
TE-12 NVnP[5pHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXQRpU2UUN3ME24NFQvPTVibl2= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
ES6 NHPKVWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTl6MT6wOkBvVQ>? NFOxeGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
LC-2-ad MnTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HMbWlEPTB;MT6xNVQxPyEQvF2= MmXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
BL-70 Ml\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvZTWM2OD1zLkGxPFQ3KM7:TR?= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
ETK-1 NYnQZ4RmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3[wUWlEPTB;MT6yPFU5KM7:TR?= M1zVTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
A4-Fuk MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fB[WlEPTB;MT6zOFE1OSEQvF2= MmrSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
OCI-AML2 NVrte2xNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTFwM{[4OVEh|ryP M3XQWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SIG-M5 MlnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPWe5R4UUN3ME2xMlM4ODB7IN88US=> NU\TcmRORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-SNU-16 NV\sUVRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvoelhKSzVyPUGuOFY1QDZizszN MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
PSN1 NXfW[pZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHabpN{UUN3ME2xMlUxPjd4IN88US=> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
SR MmLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEj1c2VKSzVyPUGuOVQ2PzJizszN NVK2cIx[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
A3-KAW M1jSdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XyZ2lEPTB;MT62NlU1PiEQvF2= Mk[2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
KS-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTFwNkmyOFch|ryP M4jROFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
CTV-1 NHr1SW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TzVWlEPTB;MT63Nlc2OSEQvF2= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
LB1047-RCC NXW5fnpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV32N5JwUUN3ME2xMlgyPjJ2IN88US=> NFXjNnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
EMG-01 M2jocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;LOWlEPTB;MT64N|U3OyEQvF2= NXmxNHd6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
TE-11 NIjEfo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\CcGo4UUN3ME2xMlg{QTh3IN88US=> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
CMK MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvNTWM2OD1zLkm1OVE4KM7:TR?= NYC4dG1DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NB1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILYUlNKSzVyPUGuPVYyOTdizszN NXfUTmZURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
HAL-01 MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJwMEW5OFYh|ryP MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
DEL NWHt[VB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnwV5ZEUUN3ME2yMlA5PDh{IN88US=> MmrZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
RL95-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrsOY9oUUN3ME2yMlEyOTN5IN88US=> MmfkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
KARPAS-299 M32wdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWj6N4VVUUN3ME2yMlEyOzF|IN88US=> MmDxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
EW-16 NVXrOG16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWK1VmpmUUN3ME2yMlE{PTB6IN88US=> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
RS4-11 NXjQTmUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLjNGxYUUN3ME2yMlE4QTJ2IN88US=> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
BB30-HNC MmPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJwMkKzO|Uh|ryP M{jvVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
DOHH-2 NITDXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\VS2hKSzVyPUKuN|M1OzFizszN M3ywNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
RPMI-8402 MljzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfQcnZyUUN3ME2yMlM{PjF6IN88US=> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
BV-173 NE\DblJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS2TWM2OD1{LkOzOlYh|ryP NGHjc4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
TE-10 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTJwM{SzPFQh|ryP NF;aTXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
TE-8 NHH4SXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rme2lEPTB;Mj6zO|A{QCEQvF2= MkjHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
K052 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTMe2tbUUN3ME2yMlQxOjB{IN88US=> MkWwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
KARPAS-45 M1rLemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HwT2lEPTB;Mj60PVQ1PiEQvF2= NYT3SFVORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
SK-NEP-1 NYX3cnczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPxPI5KSzVyPUKuOlAzOzdizszN NXnyVmpbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
KGN M3vD[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrvTWM2OD1{Lk[wN|M6KM7:TR?= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
ML-2 M2nvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXZXm9KSzVyPUKuOlM2OTJizszN NHLGUFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
LAMA-84 M3m1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13QPWlEPTB;Mj62PVU1PSEQvF2= M1HYfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
LXF-289 M{\LTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFH1N5VKSzVyPUKuO|I6QDlizszN NXjvcIVTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
A101D MlHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH0TWM2OD1{Lke4N|A1KM7:TR?= MofPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
KY821 Ml3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[wWHlKSzVyPUKuO|k4PThizszN NHTtenY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
ES4 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnsb2FsUUN3ME2yMlgxPjJ6IN88US=> MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
SCC-3 M3;vdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LGdmlEPTB;Mj64Nlg6OSEQvF2= MnXSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NALM-6 NEfUS2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXtR5VtUUN3ME2yMlkxPDd|IN88US=> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
BL-41 NF63RZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvpTWM2OD1{LkmxNlIzKM7:TR?= NFTqW|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
OPM-2 NUToS2ppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPWc|lKSzVyPUOuNFU6PTRizszN MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
SF126 NW\oTm46T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zqeWlEPTB;Mz6wOlE6QCEQvF2= MknIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
BE-13 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfZclVRUUN3ME2zMlI{OTFzIN88US=> M3PsNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SF268 NYLIZW8xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXDTWM2OD1|LkOyPFY6KM7:TR?= NYX2VZRyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
MOLT-4 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3QT29KSzVyPUOuN|k5OzhizszN NU\CeplKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
PF-382 MojpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfNbnpKSzVyPUOuOFQ2PyEQvF2= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
HEL MmC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPpelNKSzVyPUOuOFgxODVizszN NFHpdpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
RPMI-6666 NEDnWINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DGdmlEPTB;Mz61OFE4OSEQvF2= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
QIMR-WIL MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonjTWM2OD1|Lk[zN|kyKM7:TR?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
ATN-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLGTWM2OD1|Lk[3NVE1KM7:TR?= NWDEW5VsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
BB49-HNC MlvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLCeZJKSzVyPUOuO|A2ODhizszN NXflbHVsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
HCE-4 MmjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDGeIVKSzVyPUOuO|g3PDJizszN MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
SK-LMS-1 NILlboxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTNwOEOzN|gh|ryP NF:weYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
MS-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPZOVZXUUN3ME2zMlg{Pzd6IN88US=> M4LMUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
JAR NH22cZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml74TWM2OD1|Lkm4PFMzKM7:TR?= NFLTc|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
KE-37 MkPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M125eGlEPTB;ND6wOlE2QCEQvF2= M2TudFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
LB996-RCC MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknQTWM2OD12LkGyNVY5KM7:TR?= M1;ZdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
HH M4HYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnkelZKSzVyPUSuNlA6OTRizszN M1HjdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
HL-60 MlKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vQR2lEPTB;ND6yNVA3PSEQvF2= NH3CeW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
HOP-62 NWPFZnpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\oTWM2OD12LkOzOVIh|ryP NVLIPXJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NOMO-1 MlfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjUTWM2OD12LkOzOlk6KM7:TR?= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
DU-4475 Ml\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULnOJNMUUN3ME20MlM3PzJ7IN88US=> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
LC4-1 M3XwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTRwM{iwO{DPxE1? NXTTPINURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
MC116 NVXaOFZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7pUo9KSzVyPUSuOFMxQDFizszN MknoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
SW982 MlvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTRwNUWzNFch|ryP NF21W5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
SK-N-DZ NWnUOmZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTRwNkewPVkh|ryP MlPHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
EW-1 NFu5[HlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTRwNke5NVEh|ryP M4rkd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SU-DHL-1 NVXkXo5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\ofIpLUUN3ME20MlgxOTd2IN88US=> M3PDXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
L-363 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPsNY9vUUN3ME20MlgxPjJzIN88US=> NUC2N5NoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
OS-RC-2 M1PoeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHf3TJZKSzVyPUSuPFc{OSEQvF2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
HD-MY-Z M2LaWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom1TWM2OD13LkG3N|AyKM7:TR?= Ml;CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
MHH-PREB-1 MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTVwM{KzNVIh|ryP MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
HC-1 NUS0PXlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L6XWlEPTB;NT60N|I6OSEQvF2= NIDGO3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
SK-MM-2 NY[zS5FRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLTTWM2OD13LkS3PFIh|ryP NVfUPVhHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
SH-4 Ml3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3zfJBKSzVyPUWuOFg{PyEQvF2= NWm3[Jo5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
MHH-CALL-2 NGHiRYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjYeWRmUUN3ME21Mlc3PzF7IN88US=> NGPaOpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
KG-1 MlG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUOxZ4N7UUN3ME22MlAzQDd6IN88US=> M3fZeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
J-RT3-T3-5 Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkD6TWM2OD14LkC3PVA6KM7:TR?= NEHLU5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
MMAC-SF NEmxfmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fCbmlEPTB;Nj6xNFk1QSEQvF2= NVrZO5dTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
IST-SL2 NXvsTIhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLITWM2OD14LkGyOVE6KM7:TR?= M2HRVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SW954 MoXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHnNHNKSzVyPU[uNlc2OTdizszN M4Tl[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
HDLM-2 NHnhOY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTDS3dKSzVyPU[uN|IyODlizszN M{H4TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
ST486 NX;USYtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTZwM{S3NUDPxE1? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
DG-75 NXPsboM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXf4XW5QUUN3ME22MlQ{ODZ7IN88US=> M{TMTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
EW-3 MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXsO4NKSzVyPU[uOFMzODdizszN M4PhT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
8-MG-BA M2P4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLTTWM2OD14LkWxOVA4KM7:TR?= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
GT3TKB NIW5VVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH60e4hKSzVyPU[uOlA4PjNizszN M1vSNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
KU812 NWnxTZlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDyTGhKSzVyPU[uOlk1OiEQvF2= NULHOnVnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
CESS M1vmXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HKW2lEPTB;Nz6xNFQ{QCEQvF2= NWrTZZVCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
BC-1 NUf4O4lpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTdwMkS4NVIh|ryP MmrrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
MZ1-PC NVPqZYFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEThZY1KSzVyPUeuN|A{QDlizszN MkG5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NCI-H82 NVG5eHJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fnTmlEPTB;Nz6zO|g2KM7:TR?= MlfyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NCI-H1355 M1fNS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlmwTWM2OD15LkS1PFA1KM7:TR?= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
RPMI-8226 NEe1RnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLmPW9KUUN3ME23MlUxPzN7IN88US=> NUP5UGU1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
ARH-77 NHzIWWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Ppc2lEPTB;Nz61N|U6PyEQvF2= NHrQS2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
MN-60 MkHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fYdGlEPTB;Nz61OFA5QCEQvF2= M1zrdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
IMR-5 NWTTcWJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVWyeFE4UUN3ME23NFU1QDd4IN88US=> M17J[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
KARPAS-422 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTSVFY3UUN3ME23MlU4OjB4IN88US=> NXm1fm9CRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
CA46 MoDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXzcVVKSzVyPUeuOVgxOTJizszN M172clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SJSA-1 M4\PWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;PTWM2OD15Lk[2NFYyKM7:TR?= NGPOVmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
no-11 NUnhSItIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDmfFZKSzVyPUeuO|c2PTdizszN NVPxNFhuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
IST-SL1 NXv6[ZZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1ziV2lEPTB;OD6wNlQyPyEQvF2= NFHHeYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
NCI-H209 Ml\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrLOnRZUUN3ME24MlEyPjV{IN88US=> MojUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
TALL-1 MkOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HhTWlEPTB;OD6xPFM5PCEQvF2= NV3PcnB6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
KMOE-2 Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRThwMUm0NkDPxE1? NUXTUJpwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
HCC1599 MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRThwMUm5PFch|ryP MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
CI-1 NFHXPINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRThwMkC0NVEh|ryP NX71V404RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-H1304 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoP6TWM2OD16LkKwOlYyKM7:TR?= M{PmeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
Daudi MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3uxVWlEPTB;OD6yN|U1PiEQvF2= M{HNWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
CPC-N M4XmXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRThwMkmxPVkh|ryP NFy1V2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
MC-CAR MlKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvSTWM2OD16LkOzOVgh|ryP NGXhSpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
SW872 NY[zcnI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRThwM{S3OVgh|ryP NFv0Uos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
OVCAR-4 NETkdHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRThwNUCzOVEh|ryP MlLiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
OCUB-M MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRThwNU[1NFgh|ryP Ml;IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
SK-PN-DW M1HVWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:5WGFKUUN3ME24MlYxQTh3IN88US=> NYHIenRnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCCIT MlfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HSbGlEPTB;OD63NVc1PSEQvF2= NUCyUZNwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-H1648 NF3CPXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHlW4ZbUUN3ME25MlE{QDN2IN88US=> MnTDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
COR-L279 Mm\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknVTWM2OD17LkO5NFkh|ryP NH2yZ2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
LS-123 NH[weZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYO2N5V7UUN3ME25MlY5OTZzIN88US=> NHLBPGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
LP-1 MkLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF72b4JKSzVyPUmuO|gxQDNizszN NGe4N3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
NB13 M2n1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXxd|BKSzVyPUmuO|k6QTRizszN NVqybotKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
ONS-76 M2HKUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfmeoJKSzVyPUmuPFExOTZizszN NX;PbWFERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
VA-ES-BJ M4LneGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvzOIlKSzVyPUmuPVk6OzNizszN MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
GR-ST MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfKTWM2OD1zMD6yNlA4KM7:TR?= NXXq[Xp2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
ES1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nlemlEPTB;MUCuNlk5PCEQvF2= M{i2RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NB14 MoXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnHTWM2OD1zMD65Nlc4KM7:TR?= MmXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
Ramos-2G6-4C10 MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTFzLkK2OUDPxE1? M1ixR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
RXF393 MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfDTWM2OD1zMT60PFM1KM7:TR?= NV;m[3pYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-H2107 NHTN[WtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LOdWlEPTB;MUGuOVk5PCEQvF2= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
K562 NGLCempIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfpeWNKSzVyPUGxMlg4ODJizszN NH\GNJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
LOUCY NIPaZY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrPTodlUUN3ME2xNU46QDd3IN88US=> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
TGBC1TKB Mn6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUL3SZM5UUN3ME2xNk4xODJizszN NGLFfXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
COLO-320-HSR Mn7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;0N5dsUUN3ME2xNk4yPTZ3IN88US=> NXTOfXVKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
K5 M3zwN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\VTWM2OD1zMj6yPVg2KM7:TR?= NXz3OmxFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
BC-3 Mle2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH0TWM2OD1zMj60OlUyKM7:TR?= MoDaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
REH NUL3eZV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTHOpZzUUN3ME2xNk43PDl6IN88US=> M1PDdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NEC8 NV20e2N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXWfmNKSzVyPUGyMlY5QDdizszN MorlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
IST-MEL1 NU\l[JNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfQ[mZKSzVyPUGyMlg3QTRizszN MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
NCI-H128 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXRepdnUUN3ME2xN{4xPzJ|IN88US=> M2\lRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NCI-H1694 NUDzUmZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\XTWM2OD1zMz6xNVQ1KM7:TR?= NH3tS2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
TGW NIftPYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD4TWM2OD1zMz6zNlc3KM7:TR?= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
NCI-SNU-1 MnPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[4W2hKSzVyPUGzMlM1PSEQvF2= MoTBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
IST-MES1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPUd25oUUN3ME2xN{43PzJ7IN88US=> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
CTB-1 NYX6O2tvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\BblRKSzVyPUGzMlczQTRizszN MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
HUTU-80 NWDlfmt5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDlUHNKSzVyPUGzMlc2PzNizszN NYPHV2twRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
LAN-6 NYnnSG5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnWxTWM2OD1zND6yOFU4KM7:TR?= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
KP-N-YS NEDLdFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{SzUmlEPTB;MUSuNlg6PCEQvF2= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
CCRF-CEM M4qxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfJWnZKSzVyPUG0MlQyPjlizszN MlvzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NCI-H1770 Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIC4SY9KSzVyPUG0MlU{PjlizszN MkXRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
MZ2-MEL NEfPR2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Tv[2lEPTB;MUWuNlI2OSEQvF2= MkDnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
COR-L88 NUO1clRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL5RYVqUUN3ME2xOk4xODF{IN88US=> Ml\OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
LOXIMVI MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmriTWM2OD1zNj6yOVYh|ryP NWXMWlRFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
KALS-1 M{PF[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\Q[HU{UUN3ME2xOk42QTNzIN88US=> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
D-283MED NGjUOY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4S5c2lEPTB;MU[uPFQ5QSEQvF2= M{m5dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NCI-H719 MoH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGL0dW5KSzVyPUG2MlkyPjFizszN MmXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
MLMA NILqOoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTzeIFKSzVyPUG2Mlk6ODdizszN M1;mV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
EVSA-T NWmySGtIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{T1bWlEPTB;MUeuNFQ5PSEQvF2= M3HWeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SK-N-FI NX;LWpd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3uTWM2OD1zNz62PVE{KM7:TR?= NEn2[5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
NTERA-S-cl-D1 NWLNVXNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\3eI1KSzVyPUG3Mlg2PzJizszN NG\Wfoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
NCI-H1882 NWPue21iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkewTWM2OD1zNz65PFM1KM7:TR?= NUf5c5FKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
A704 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmexTWM2OD1zNz65PVA1KM7:TR?= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
L-428 NFzvOJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGWzfYtKSzVyPUG4MlAyPTFizszN NUPaOnpNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
HCC1187 M2K0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{X0c2lEPTB;MUiuNFE5PyEQvF2= NYrFb4VTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-H1581 NFrrSY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWe4OGYxUUN3ME2xPE4xQDZ4IN88US=> M{fmZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
BB65-RCC NXLROodxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjrW|NXUUN3ME2xPE41OTZ{IN88US=> MnfEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
EM-2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTF6LkW2O|Ih|ryP MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
Raji MlywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTF7Lkm1OlUh|ryP NXH6R5hsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
TE-1 M1nPdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTJyLkSxNFQh|ryP MmL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
SW962 NEjidpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\vPXFKSzVyPUKwMlQzQTNizszN MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
MHH-NB-11 MnT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M16xb2lEPTB;MkCuOVUzOSEQvF2= Moj5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
no-10 M17u[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJzLkCyOlQh|ryP NFzHPHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
GDM-1 NGm1eXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLYTWM2OD1{MT65OFE1KM7:TR?= NXjFNZV5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
KMS-12-PE M2fwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJ{LkK3OEDPxE1? NYLnZXBERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-H510A MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3kTWM2OD1{ND6xNlc5KM7:TR?= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
ES5 M{nwdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3u5bmlEPTB;MkSuO|M1QSEQvF2= NF;lWI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
JiyoyeP-2003 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJ4LkK3OFIh|ryP MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
NMC-G1 Mn:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGO5emxKSzVyPUK3MlE5OjJizszN NVrZOFZERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-H446 NG[3b4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2X1eGlEPTB;MkeuOFk1PiEQvF2= MnzYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NB7 NHm4c5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvLXnNKSzVyPUK3MlkzOjlizszN MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
A388 Mk\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrCW4k4UUN3ME2yPE4xODd2IN88US=> NUHyU4M2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
JVM-2 NGPofodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3WTWM2OD1{OD6yPFk5KM7:TR?= M4\vfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
HT-144 NH;PTJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy1WnhKSzVyPUK4MlY6KM7:TR?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
NCI-H747 NHLSOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H1e2lEPTB;MkiuPVE6PSEQvF2= NETYOoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
NCI-H1650 MnTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2[wdWlEPTB;MkmuNFE4PiEQvF2= MnHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
EB-3 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrwTWM2OD1{OT61N|A6KM7:TR?= M3zlbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
KLE M{\QWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz3XGc4UUN3ME2yPU43OTlizszN NEP2do49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
TK10 NFfjUmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLOTWM2OD1|MD6xNlYh|ryP M4\hSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
COLO-668 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTNyLke5NkDPxE1? M2qwfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NCI-H23 NX;5WHZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojXTWM2OD1|MT6xNFY{KM7:TR?= NHzoTHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
GOTO Mo\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PtUmlEPTB;M{GuOlA5PSEQvF2= M37Ie|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
MSTO-211H MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrsTWM2OD1|MT64Olc5KM7:TR?= M3\zVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
LB831-BLC MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT2TWM2OD1|Mj6zPFQ{KM7:TR?= M{POW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SCH MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTN{Lki0PFUh|ryP M2LBZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
EHEB MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTN2LkGxPVMh|ryP M12yfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
U-266 MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIP0eItKSzVyPUO0MlI4QDFizszN MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
EW-11 NFG0XolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzrTWM2OD1|ND60O|I2KM7:TR?= M2jZflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
TE-9 M2LFSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTN5LkC0NFEh|ryP MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
ES3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzXTWM2OD1|Nz61NFA1KM7:TR?= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
NCI-H2141 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIm4Z2tKSzVyPUO4MlA5PDNizszN NYfjWVVuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
MPP-89 M1PSWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;SXWlEPTB;NEKuNFU5PiEQvF2= NGfOT3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
SK-MEL-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUCxTGdDUUN3ME20Nk43PDB3IN88US=> NHvnOoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
LC-1F NUHSelhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mor0TWM2OD12Mz6zOlgzKM7:TR?= Mn:0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NH-12 NVPuPZFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPJZpRXUUN3ME20N{46OzV7IN88US=> NGrod5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
RKO NVz5TJdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NViwOZE4UUN3ME20OE4yOjV{IN88US=> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N|UwLz6VQV7HSXI9N2F-
KM-H2 NVuxdXV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\GTWM2OD12ND65OVc4KM7:TR?= NVHwOHV5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
SK-UT-1 NV[3eHdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjhRpBKSzVyPUS5Mlg5OjVizszN NVrrV3E5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-STAT3 / STAT3 / p-Src / Src / p-AKT / AKT / p-ERK / ERK ; 

PubMed: 19244102     


Sunitinib reduced Stat3 and Src activity, with no dramatic reduction of AKT, MAPK and JAK signaling in 786-O cells. Tumor cells were treated with sunitinib at indicated concentrations for 2 h (left panels) or 24 h (right panels). Total cell lysates were prepared and western blots were performed using relevant antibodies to detect total protein levels, with β-actin used as the loading control.

p-GSK3β / GSK3β / MYCN ; 

PubMed: 24759734     


Effect of sunitinib on GSK3β phosphorylation and on MYCN total protein in MYCN amplified NB cell lines.

p-AKT / AKT / p-ERK / ERK; 

PubMed: 24759734     


Effect of 72 h treatment with sunitinib on SH-SY5Y, SK N BE(2), SK-N-AS and IMR-32 NB cell lines analyzed by Western blot with pSer473Akt, Akt, pThr202/Thr204 Erk1/2 and Erk1/2 antibodies. β-actin was used as a loading control.

19244102 24759734
Growth inhibition assay
Cell viability; 

PubMed: 24369536     


Isolated effects of sunitinib malate on urinary bladder-cancer cell lines viability, assessed by using the MTT assay. The data shown and bars represent the mean values ± SD (SD: standard deviation). *P < 0.05 versus untreated cells.

24369536
In vivo

Consistent with the substantial and selective inhibition of VEGFR2 or PDGFR phosphorylation and signaling in vivo, Sunitinib (20-80 mg/kg/day) exhibits broad and potent dose-dependent anti-tumor activity against a variety of tumor xenograft models including HT-29, A431, Colo205, H-460, SF763T, C6, A375, or MDA-MB-435. Sunitinib dosing at 80 mg/kg/day for 21 days leads to complete tumor regression in six of eight mice, without tumor re-growing during a 110-day observation period after the end of treatment. Second round of treatment with Sunitinib remains efficacious against tumors that are not fully regressed during the first round of treatment. Sunitinib treatment results in significant decrease in tumor MVD, with ~40% reduction in SF763T glioma tumors. SU11248 treatment results in a complete inhibition of additional tumor growth of luciferase-expressing PC-3M xenografts, despite no reduction in tumor size. [2] Sunitinib treatment (20 mg/kg/day) dramatically suppresses the growth subcutaneous MV4;11 (FLT3-ITD) xenografts and prolongs survival in the FLT3-ITD bone marrow engraftment model. [3]

Protocol

Kinase Assay:

[1]

- Collapse

Biochemical Tyrosine Kinase Assays:

IC50 values for Sunitinib against VEGFR2 (Flk-1) and PDGFRβ are determined using glutathione S-transferasefusion proteins containing the complete cytoplasmic domain of the RTK. Biochemical tyrosine kinase assays to quantitate the trans-phosphorylation activity of VEGFR2 (Flk-1) and PDGFRβ are performed in 96-well microtiter plates precoated (20 μg/well in PBS; incubated overnight at 4 °C) with the peptide substrate poly-Glu,Tyr (4:1). Excess protein binding sites are blocked with the addition of 1-5% (w/v) BSA in PBS. Purified GST-fusion proteins are produced in baculovirus-infected insect cells. GST-VEGFR2 and GST-PDGFRβ are then added to the microtiter wells in 2 × concentration kinase dilution buffer consisting of 100 mM HEPES, 50 mM NaCl, 40 μM NaVO4, and 0.02% (w/v) BSA. The final enzyme concentration for GST-VEGFR2 or GST-PDGFRβ is 50 ng/mL. Twenty-five μL of diluted Sunitinib are subsequently added to each reaction well to produce a range of inhibitor concentrations appropriate for each enzyme. The kinase reaction is initiated by the addition of different concentrations of ATP in a solution of MnCl2 so that the final ATP concentrations spanned the Km for the enzyme, and the final concentration of MnCl2 is 10 mM. The plates are incubated for 5-15 minutes at room temperature before stopping the reaction with the addition of EDTA. The plates are then washed three times with TBST. Rabbit polyclonal antiphosphotyrosine antisera are added to the wells at a 1:10,000 dilution in TBST containing 0.5% (w/v) BSA, 0.025% (w/v) nonfat dry milk, and 100 μM NaVO4 and incubated for 1 hour at 37 °C. The plates are then washed three times with TBST, followed by the addition of goat antirabbit antisera conjugated with horseradish peroxidase (1:10,000 dilution in TBST). The plates are incubated for 1 hour at 37 °C and then washed three times with TBST. The amount of phosphotyrosine in each well is quantitated after the addition of 2,2′-azino-di-[3-ethylbenzthiazoline sulfonate] as substrate.
Cell Research:

[3]

- Collapse
  • Cell lines: RS4;11, MV4;11, and OC1-AML5
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 24 and 48 hours
  • Method:

    Cells are starved overnight in medium containing 0.1% FBS prior to addition of Sunitinib and FL (50 ng/mL; FLT3-WT cells only). Proliferation is measured after 48 hours of culture using the Alamar Blue assay or trypan blue cell viability assays. Apoptosis is measured 24 hours after Sunitinib addition by Western blotting to detect cleavage of poly (ADP-ribose) polymerase (PARP) or levels of caspase-3.


    (Only for Reference)
Animal Research:

[2]

- Collapse
  • Animal Models: Female nu/nu mice implanted s.c. with HT-29, A431, Colo205, H-460, SF763T, C6, A375, or MDA-MB-435, and male nu/nu mice bearing luciferase-expressing PC-3M tumors
  • Dosages: ~80 mg/kg
  • Administration: Orally once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 15 mg/mL (28.16 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C22H27FN4O2.C4H6O5

CAS No. 341031-54-7
Storage powder
in solvent
Synonyms N/A
Smiles CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04669366 Recruiting Drug: sunitinib|Drug: axitinib Kidney Neoplasms Pfizer January 20 2021 --
NCT04633122 Recruiting Drug: Ripretinib|Drug: Sunitinib Gastrointestinal Stromal Tumor(GIST) Zai Lab (Shanghai) Co. Ltd. November 25 2020 Phase 2
NCT04115189 Completed Drug: Sunitinib Metastatic Renal Cell Carcinoma ( mRCC) Pfizer December 13 2019 --
NCT04175262 Completed Drug: sunitinib Metastatic Renal Cell Carcinoma (mRCC) Pfizer|IMDC group|Analysis Group October 31 2019 --
NCT04033991 Completed Drug: Sunitinib|Drug: Axitinib Carcinoma|Renal Cell Pfizer September 27 2019 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I was wondering that the compound is in its cis or trans form?

  • Answer:

    S1042 Sunitinib Malate is Z form.

  • Question 2:

    What is the difference between Sunitinib Malate(S1042) and Sunitinib(S7781)?

  • Answer:

    S1042 is the Malate salt form of Sunitinib. The biological activities of these two compounds are the same but the solubility of these two compounds in aqueous solvent are different.

PDGFR Signaling Pathway Map

PDGFR Inhibitors with Unique Features

Related PDGFR Products

Tags: buy Sunitinib (SU11248) malate | Sunitinib (SU11248) malate supplier | purchase Sunitinib (SU11248) malate | Sunitinib (SU11248) malate cost | Sunitinib (SU11248) malate manufacturer | order Sunitinib (SU11248) malate | Sunitinib (SU11248) malate distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID