Sunitinib (SU11248) malate

Name: Sunitinib (SU11248) malate
Brand: Selleck Chemicals
SKU: S1042
Rating: 5 (115 reviews)

For research use only.

Licensed by Pfizer Catalog No.S1042

115 publications

Sunitinib (SU11248) malate Chemical Structure

CAS No. 341031-54-7

Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.

Selleck's Sunitinib (SU11248) malate has been cited by 115 publications

Cell, 2019, 36(2):179-193

PubMed: 28162770 ( click the link to review the publication )

Cancer Cell, 2019, 36(2):179-193

PubMed: 31378681 ( click the link to review the publication )

Nature, 2011, 478(7369):349-55

PubMed: 21993628 ( click the link to review the publication )

Adv Sci (Weinh), 2021, 8(2):2001596

PubMed: 33510997 ( click the link to review the publication )

Blood Cancer J, 2021, 11(3):57

PubMed: 33714981 ( click the link to review the publication )

Cancers (Basel), 2021, 13(11)2574

PubMed: 34073906 ( click the link to review the publication )

J Clin Endocrinol Metab, 2021, dgab020

PubMed: 33524147 ( click the link to review the publication )

Front Oncol, 2021, 11:648097

PubMed: 33842362 ( click the link to review the publication )

Toxicol Sci, 2021, kfab033

PubMed: 33749749 ( click the link to review the publication )

ACS Biomater Sci Eng, 2021, 7(6):2569-2579

PubMed: 34061498 ( click the link to review the publication )

Sci Rep, 2021, 11(1):12148

PubMed: 34108527 ( click the link to review the publication )

Sci Rep, 2021, 11(1):10200

PubMed: 33986386 ( click the link to review the publication )

Cancer Gene Ther, 2021, 10.1038/s41417-021-00345-1

PubMed: 34088993 ( click the link to review the publication )

Drug Metab Dispos, 2021, 49(1):53-61

PubMed: 33148688 ( click the link to review the publication )

Int J Oncol, 2021, 59(1)48

PubMed: 34036385 ( click the link to review the publication )

Transl Oncol, 2021, 14(7):101099

PubMed: 33887553 ( click the link to review the publication )

PLoS One, 2021, 16(7):e0253258

PubMed: 34234354 ( click the link to review the publication )

Oncol Lett, 2021, 21(4):294

PubMed: 33732370 ( click the link to review the publication )

Mol Med Rep, 2021, 23(1)40

PubMed: 33179075 ( click the link to review the publication )

Biomedicines, 2021, 9(6)627

PubMed: 34072926 ( click the link to review the publication )

Int J Breast Cancer, 2021, 2021:8818393

PubMed: 33936816 ( click the link to review the publication )

Eur J Pharmacol, 2021, 895:173868

PubMed: 33460613 ( click the link to review the publication )

Cancers (Basel), 2021, 13(4)653

PubMed: 33562152 ( click the link to review the publication )

Nat Protoc, 2020, 15(2):421-449

PubMed: 31932771 ( click the link to review the publication )
Cancer Res, 2020, canres.1992.2020

PubMed: 33203698 ( click the link to review the publication )

J Clin Med, 2020, 9(3)

PubMed: 32131507 ( click the link to review the publication )

Front Oncol, 2020, 10:516552

PubMed: 33072561 ( click the link to review the publication )

J Cell Mol Med, 2020, 24(24):14441-14452

PubMed: 33145941 ( click the link to review the publication )

Cancer Cell Int, 2020, 19;20:58

PubMed: 32099531 ( click the link to review the publication )

Metabolites, 2020, 11(1)E1

PubMed: 33374949 ( click the link to review the publication )

PLoS One, 2020, 15(8):e0232917

PubMed: 32810161 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00420-z

PubMed: 32870449 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00425-8

PubMed: 32886306 ( click the link to review the publication )

Neoplasia, 2020, 22(10):470-483

PubMed: 32818841 ( click the link to review the publication )

Cell Syst, 2019, 8(2):97-108

PubMed: 30797775 ( click the link to review the publication )

FASEB J, 2019, 33(1):1347-1359

PubMed: 30148679 ( click the link to review the publication )

Oncoimmunology, 2019, 8(2):e1543526

PubMed: 30713805 ( click the link to review the publication )

Biomolecules, 2019, 9(11)

PubMed: 31683643 ( click the link to review the publication )

Expert Opin Ther Targets, 2019, 23(9):805-817

PubMed: 31385548 ( click the link to review the publication )

IEEE Trans Biomed Eng, 2019, 66(3):873-880

PubMed: 30059292 ( click the link to review the publication )

Sci Rep, 2019, 9(1):6004

PubMed: 30979919 ( click the link to review the publication )

Sci Rep, 2019, 9(1):1897

PubMed: 30760778 ( click the link to review the publication )

Oncol Rep, 2019, 42(5):2039-2048

PubMed: 31485624 ( click the link to review the publication )

AAPS PharmSciTech, 2019, 20(7):281

PubMed: 31399890 ( click the link to review the publication )

Pharm Biol, 2019, 57(1):625-631

PubMed: 31545912 ( click the link to review the publication )

Theranostics, 2018, 8(1):141-155

PubMed: 29290798 ( click the link to review the publication )

EBioMedicine, 2018, 27:225-236

PubMed: 29289530 ( click the link to review the publication )

Cancers (Basel), 2018, 10(10)E365

PubMed: 30274248 ( click the link to review the publication )
Endocr Relat Cancer, 2018, 25(4):471-480

PubMed: 29440231 ( click the link to review the publication )

J Lipid Res, 2018, 59(11):2188-2201

PubMed: 30173145 ( click the link to review the publication )

Chem Biol Interact, 2018, 294:1-8

PubMed: 30125546 ( click the link to review the publication )

Transl Oncol, 2018, 11(6):1406-1418

PubMed: 30219696 ( click the link to review the publication )

Cancer Chemother Pharmacol, 2018, 82(1):65-75

PubMed: 29721849 ( click the link to review the publication )

Cell Death Dis, 2018, 9(10):1018

PubMed: 30282966 ( click the link to review the publication )

Assay Drug Dev Technol, 2018, 16(7):408-419

PubMed: 29985634 ( click the link to review the publication )

J Clin Invest, 2017, 127(4):1338-1352

PubMed: 28240606 ( click the link to review the publication )

Cancer Res, 2017, 77(4):1008-1020

PubMed: 28011623 ( click the link to review the publication )

Arch Toxicol, 2017, 91(8):2921-2938

PubMed: 28032146 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(11):2502-2515

PubMed: 28729403 ( click the link to review the publication )

Hum Mol Genet, 2017, 26(22):4375-4387

PubMed: 28973155 ( click the link to review the publication )

J Am Heart Assoc, 2017, 6(10)

PubMed: 29051215 ( click the link to review the publication )

J Biol Chem, 2017,

PubMed: 27903634 ( click the link to review the publication )

Oncotarget, 2017, 8(40):68270-68279

PubMed: 28978115 ( click the link to review the publication )

Oncotarget, 2017, 8(13):20881-20894

PubMed: 28152509 ( click the link to review the publication )

Oncotarget, 2017, 9(1):802-811

PubMed: 29416656 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2016, 113(33):9339-44

PubMed: 27482107 ( click the link to review the publication )

Elife, 2016, 5e11405

PubMed: 27841748 ( click the link to review the publication )

Oncogene, 2016, 35(21):2687-97

PubMed: 26364599 ( click the link to review the publication )

Cancer Lett, 2016, 374(2):250-60

PubMed: 26921131 ( click the link to review the publication )

Dis Esophagus, 2016, 29(8):1144-1151

PubMed: 26542732 ( click the link to review the publication )

Oncol Lett, 2016, 12(6):4671-4676

PubMed: 28105174 ( click the link to review the publication )

Oncotarget, 2016, 7(29):45015-45026

PubMed: 27304187 ( click the link to review the publication )
Sci Transl Med, 2015, 7(284):284ra57

PubMed: 25904741 ( click the link to review the publication )

Neurobiol Dis, 2015, 74:114-25

PubMed: 25461258 ( click the link to review the publication )

Exp Cell Res, 2015, 332(1):1-10

PubMed: 25637219 ( click the link to review the publication )

Biochem Biophys Res Commun, 2015, 10.1016/j.bbrc.2015.04.107

PubMed: 25935484 ( click the link to review the publication )

Pulm Pharmacol Ther, 2015, 10.1016/j.pupt.2015.03.001

PubMed: 25843005 ( click the link to review the publication )

Clin Cancer Res, 2014, 20(9):2410-23

PubMed: 24573550 ( click the link to review the publication )

Leukemia, 2014, 28(11):2197-205

PubMed: 24699302 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2014, 111(14):5319-24

PubMed: 24623852 ( click the link to review the publication )

Ann Surg, 2014, 259(4):793-9

PubMed: 24045439 ( click the link to review the publication )

Int J Cancer, 2014, 10.1002/ijc.29414

PubMed: 25556636 ( click the link to review the publication )

Oncogene, 2014, 33(19):2531-9

PubMed: 23728343 ( click the link to review the publication )

Br J Pharmacol, 2014, 171(24):5728-42

PubMed: 25091695 ( click the link to review the publication )

Br J Cancer, 2014, 111(6):1168-7

PubMed: 25093491 ( click the link to review the publication )

Neurobiol Dis, 2014, 10.1016/j.nbd.2014.10.024

PubMed: ( click the link to review the publication )

Cancer Cell Int, 2014, 14(1):89

PubMed: 25253994 ( click the link to review the publication )

Cancer Cell Int, 2014, 14:89

PubMed: ( click the link to review the publication )

Drug Metab Dispos, 2014, 42(11):1851-7

PubMed: 25165131 ( click the link to review the publication )

Cell Cycle, 2014,

PubMed: 25426675 ( click the link to review the publication )

Cell Cycle, 2014, 13(24):3808-17

PubMed: ( click the link to review the publication )

Transl Oncol, 2014, 19(9):2368-80

PubMed: 23633458 ( click the link to review the publication )

PLoS One, 2014, 9(4):e96024

PubMed: 24770423 ( click the link to review the publication )

PLoS One, 2014, 9(1):e85759

PubMed: 24454929 ( click the link to review the publication )

Korean J Parasitol, 2014, 52(4):439-41

PubMed: 25246725 ( click the link to review the publication )

Oncotarget, 2014, 5(16):6801-15

PubMed: 25149535 ( click the link to review the publication )
Cytometry A, 2014, 85(6):537-47

PubMed: 24664821 ( click the link to review the publication )

Cancer Res, 2013, 73(23):6886-99

PubMed: 24145351 ( click the link to review the publication )

Cancer Lett, 2013, 340(1):43-50

PubMed: 23811285 ( click the link to review the publication )

Mol Cancer Ther, 2013, 12(10):2018-30

PubMed: 23920274 ( click the link to review the publication )

Apoptosis, 2013, 19(4):682-97

PubMed: 24337903 ( click the link to review the publication )

Mol Cell Endocrinol, 2013, 377(1-2):1-6

PubMed: 23811235 ( click the link to review the publication )

Acta Oncol, 2013, 53(5):637-45

PubMed: 24041258 ( click the link to review the publication )

Am J Nucl Med Mol Imaging, 2013, 3(5):397-407

PubMed: 24116348 ( click the link to review the publication )

SENSOR ACTUAT B-CHEM, 2012, Jin Akagi

PubMed: ( click the link to review the publication )

Surgery, 2012, 152(6):1045-50

PubMed: 23102636 ( click the link to review the publication )

Surgery, 2012, 152(6):1142-9

PubMed: 23158184 ( click the link to review the publication )

J Biomol Screen, 2012, 17(6):813-21

PubMed: 22453235 ( click the link to review the publication )

J Biomol Screen, 2012, 18(4):388-99

PubMed: 23134735 ( click the link to review the publication )

Cell Res, 2011, 21(7):1080-7

PubMed: 21423276 ( click the link to review the publication )

Cancer Res, 2011, 71(5):1637-46

PubMed: 21343392 ( click the link to review the publication )

Mol Cancer Ther, 2011, 10(10):1897-908

PubMed: 21825009 ( click the link to review the publication )

Blood, 2010, 115(23):4725-33

PubMed: 20185585 ( click the link to review the publication )

Dis Model Mech, 2010, 3(5-6):343-53

PubMed: 20335444 ( click the link to review the publication )

Biochem Bioph Res Co, 2010, 398(2):205-11

PubMed: 20599738 ( click the link to review the publication )

Purity & Quality Control

Choose Selective PDGFR Inhibitors

Biological Activity

Description

Targets

IRE1α ^[7] ()	Kit ^[1] (Cell-free assay)	FLT3 ^[1] (Cell-free assay)	PDGFRβ ^[1] (Cell-free assay)	VEGFR2 ^[1] (Cell-free assay)
			2 nM	80 nM

In vitro

Sunitinib also potently inhibits Kit and FLT-3. ^[1] Sunitinib is a potent ATP-competitive inhibitor of VEGFR2 (Flk1) and PDGFRβ with K_i of 9 nM and 8 nM, respectively, displaying >10-fold higher selectivity for VEGFR2 and PDGFR than FGFR-1, EGFR, Cdk2, Met, IGFR-1, Abl, and src. In serum-starved NIH-3T3 cells expressing VEGFR2 or PDGFRβ, Sunitinib inhibits VEGF-dependent VEGFR2 phosphorylation and PDGF-dependent PDGFRβ phosphorylation with IC50 of 10 nM and 10 nM, respectively. Sunitinib inhibits VEGF-induced proliferation of serum-starved HUVECs with IC50 of 40 nM, and inhibits PDGF-induced proliferation of NIH-3T3 cells overexpressing PDGFRβ or PDGFRα with IC50 of 39 nM and 69 nM, respectively. ^[2] Sunitinib inhibits phosphorylation of wild-type FLT3, FLT3-ITD, and FLT3-Asp835 with IC50 of 250 nM, 50 nM, and 30 nM, respectively. Sunitinib inhibits the proliferation of MV4;11 and OC1-AML5 cells with IC50 of 8 nM and 14 nM, respectively, and induces apoptosis in a dose-dependent manner. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
3T3	NFLhS5lMcW6jc3WgRZN{[Xl?				Mn;2TY5pcWKrdHnvckBw\iCSRFfGMYlv\HWlZXSgRpJlXSCrbnPvdpBwemG2aX;uJJdqfGhiSVO1NEBw\iByLkCwO{DPxE1?	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ2NkCxPUc,OTJ4NE[wNVk9N2F-
3T3	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NF;kV4hKdmirYnn0bY9vKG:oIGDsZZRmdGW2LXTldol3\WRiZ4Lve5RpKG[jY4TvdkBqdmS3Y3XkJFNVOyClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODFizszN	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ2NkCxPUc,OTJ4NE[wNVk9N2F-
3T3	MlLySpVv[3Srb36gRZN{[Xl?				NF;xPIxKdmirYnn0bY9vKG:oIG\hd4N2dGG{IHXu[I91cGWuaXHsJIdzd3e2aDDmZYN1d3JicnXj[ZB1d3Jid3n0bEBKSzVyIH;mJFAvODVizszN	NHvSV3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[0OlAyQSd-MUK2OFYxOTl:L3G+
3T3	M12yV2tqdmG\|ZTDBd5NigQ>?		Mlm3NlAhdWmw	M3P3PWROW09?	M3z5XmNmdGy3bHHyJIlvcGmkaYTpc44hd2ZiVlXHSkBqdmS3Y3XkJIh2dWGwIFvEVkBxcG:\|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEKyJO69VQ>?	NV31SHllRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[xOlIxODhpPkG2NVYzODB6PD;hQi=>
NIH3T3	NIjSfHhMcW6jc3WgRZN{[Xl?		M136XVIxKG2rbh?=	MVnEUXNQ	MX7pcohq[mm2IHj1cYFvKEuGUjDrbY5ie2ViZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAxNjBzODFOwG0>	MlH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZzNkKwNFgoRjF4MU[yNFA5RC:jPh?=
A549	MWnGeY5kfGmxbjDBd5NigQ>?			MY\EUXNQ	NGLhTmVKdmirYnn0bY9vKG:oIHOtUYV1KGSncHXu[IVvfCCKR1[tbY5lfWOnZDDoeY1idiCDNUS5JINmdGxibXnndoF1cW:wIIfpeIghUUN3MDDv[kAzKM7:TR?=	MnHSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2M{SxOFUoRjF6NEO0NVQ2RC:jPh?=
DU145	M4LhSmZ2dmO2aX;uJGF{e2G7			MlPNSG1UVw>?	M1TQOWlvcGmkaYTpc44hd2ZiYz3N[ZQh\GWyZX7k[Y51KEiJRj3pcoR2[2WmIHj1cYFvKESXMUS1JINmdGxic3PheJRmemmwZzD3bZRpKEmFNUCgc4YhOTBizszN	NV[1PHdPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0N\|QyPDVpPkG4OFM1OTR3PD;hQi=>
KB3-1	Mo\SR5l1d3SxeHnjJGF{e2G7		MVS3NkBp	MXzEUXNQ	MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQMYdxNW6nZ3H0bZZmKEuELUOtNUBk\WyuczD3bZRpKEmFNUCgc4YhOi5\|IN88US=>	MmrIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|OUezNlIoRjF7M{m3N\|IzRC:jPh?=
KBV1	NV3qc2RES3m2b4TvfIlkKEG\|c3H5		MYG3NkBp	NYjWc5Y1TE2VTx?=	NI\SeI1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRNWeueXPvdJJwfGWrbj3lfJBz\XO\|aX7nJGtDXjFiY3XscJMhf2m2aDDJR\|UxKG:oIESuNUDPxE1?	M2PCU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m3N\|IzLz5zOUO5O\|MzOjxxYU6=
A375	MYHDfZRwfG:6aXOgRZN{[Xl?		M1T1R\|czKGh?	MofXSG1UVw>?	MkLSTWM2OD13LkSg{txO	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ3NESwPEc,OTl4NUS0NFg9N2F-
RS4-11	NV7DcHdCTnWwY4Tpc44hSXO\|YYm=		NUf3Tm9sOiCq		M2fpT2lvcGmkaYTpc44hd2ZiRlzUN{BifXSxcHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxQTlizszN	MorzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4NUS0NFgoRjF7NkW0OFA5RC:jPh?=
RS4-11	MUfGeY5kfGmxbjDBd5NigQ>?		MViyJIg>		NF;aO41KdmirYnn0bY9vKG:oIF\MWFMhUVSGIH31eIFvfCCjdYTvdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjB\|NDFOwG0>	NVHrOXVbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm2OVQ1ODhpPkG5OlU1PDB6PD;hQi=>
Sf9	NV\6RWRwU2mwYYPlJGF{e2G7		MUOzNEBucW5?		M1uwbWlvcGmkaYTpc44hd2ZiR2PUMZRi\2enZDDWSWdHWiCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFAvOTh3IN88US=>	MofYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6NUSwOVEoRjF7OEW0NFUyRC:jPh?=
Ba/F3	NUfaTFV{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M1XzfVczKGh?		NF;1b4pKSzVyPUGuNkDPxE1?	NXfp[\|cxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNVcxODRpPkKwNVE4ODB2PD;hQi=>
BaPTC2	MlTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M1:5XVczKGh?		MlPuTWM2OD1yLkKyJO69VQ>?	NXy4R\|RZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNVcxODRpPkKwNVE4ODB2PD;hQi=>
Sf9	NFX4NZZHfW6ldHnvckBCe3OjeR?=		NGOzS2kyKGh?	MkOxSG1UVw>?	MWfJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEircz30ZYdo\WRiUlXUJIV5eHKnc4Pl[EB4cXSqIFnDOVAhd2ZiMT6zJO69VQ>?	MmXuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMUewNFQoRjJyMUG3NFA1RC:jPh?=
H4	MUjDfZRwfG:6aXOgRZN{[Xl?	M2jCVFExKM7:TR?=			M3fNTXRwgGmlaYT5JIlvKGi3bXHuJGg1KGOnbHzz	NX3BV2dDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA5ODZpPkKwN\|UxQDB4PD;hQi=>
SF-539	NV;tXphqU2mwYYPlJGF{e2G7	M3\MSFM{OyEQvF2=	NWnmWGxbPjBibXnu	MmP6SG1UVw>?	NV\zbVNsUW6qaXLpeIlwdiCxZjDQSGdHWmKndHGgdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAyOi5{IN88US=>	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODRyM{ewNEc,OjB2MEO3NFA9N2F-
U251	NH3t[WxMcW6jc3WgRZN{[Xl?	NXzmeohSOzN\|IN88US=>	NYrnd5RnPjBibXnu	MVvEUXNQ	MoK3TY5pcWKrdHnvckBw\iCYRVfGVlIheGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iBzOD65JO69VQ>?	NEDtO2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MESwN\|cxOCd-MkC0NFM4ODB:L3G+
A431	M2rKPWtqdmG\|ZTDBd5NigQ>?				M2DoU2lvcGmkaYTpc44hd2ZiUFTHSnJj\XSjIHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOTJwMjFOwG0>	M2POcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUW4NFczLz5{MEW1PFA4OjxxYU6=
A431	NXzVW2p1U2mwYYPlJGF{e2G7				MVfJcohq[mm2aX;uJI9nKF[HR1\SNkBmgHC{ZYPz[YQhf2m2aDDJR\|UxKG:oIEG4Mlkh\|ryP	MofJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3NUiwO\|IoRjJyNUW4NFczRC:jPh?=
HepG2	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NUXPUVVkPzJiaB?=		NEG0cYdKSzVyPUOuPFEh\|ryP	NXu0OVk2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1O\|A2OjZpPkKwOVcxPTJ4PD;hQi=>
Kasumi-1	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M4PTd\|czKGh?		MVXJR\|UxRTBwMEG2JO69VQ>?	M{PPclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUewOVI3Lz5{MEW3NFUzPjxxYU6=
RS4-11	NWDSNoxqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MVS3NkBp		NET3WlRKSzVyPUGg{txO	NVXqNZZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1O\|A2OjZpPkKwOVcxPTJ4PD;hQi=>
THP1	MoqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NWrNS\|VLPzJiaB?=		NYC3cJA5UUN3ME2wMlUh\|ryP	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODV5MEWyOkc,OjB3N{C1NlY9N2F-
Kasumi-1	MYLGeY5kfGmxbjDBd5NigQ>?				M1PHNmlvcGmkaYTpc44hd2ZiYz3LbZQh[XW2b4Doc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4xOTVizszN	NXHzNpFmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4N\|MxOzlpPkKwPFM{ODN7PD;hQi=>
A549	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M3HNb\|E3KGh?		M{nReGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIO=	NYrxfmVuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ\|PD;hQi=>
HL60	M4TCbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NGnyWWcyPiCq		NH\EPGlCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzz	NWnId\|NPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ\|PD;hQi=>
HUVEC	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NVvlXIluOTZiaB?=		M3XSZmlvcGmkaYTpc44hd2ZiVlXHSk1qdmS3Y3XkJINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiMj63OUDPxE1?	NVTOVlhlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ\|PD;hQi=>
HUVEC	NGfnTYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MYSxOkBp		NIjTd\|VKdmirYnn0bY9vKG:oIHLGS2YucW6mdXPl[EBk\WyuIIDyc4xq\mW{YYTpc44hf2m2aDDJR\|UxKG:oIESuNFQh\|ryP	NVq2NHAyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVA1PjNpPkKxOFUxPDZ\|PD;hQi=>
IM9	NIrFcGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M4SyNFE3KGh?		M2Xu[GFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFnNPUBk\Wyucx?=	Mn7lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUC0OlMoRjJzNEWwOFY{RC:jPh?=
K562	NI[3ZVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M1fXWVE3KGh?		NXzFWYN7SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsdy=>	NEHmPXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS1NFQ3Oyd-MkG0OVA1PjN:L3G+
MDA-MB-231	NFuyV4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NIX4WZcyPiCq		MkPyRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ\|MTDj[Yxtew>?	NF;FbYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS1NFQ3Oyd-MkG0OVA1PjN:L3G+
H460	MnzjR5l1d3SxeHnjJGF{e2G7		NX\SR3p6PzJiaB?=		M3HsTWlEPTB;Mj63JO69VQ>?	M4PCVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkKxPFgxLz5{MU[yNVg5ODxxYU6=
SMMC7721	NITrflFEgXSxdH;4bYMhSXO\|YYm=		MUS3NkBp		M1H3NWlEPTB;Nj60O{DPxE1?	NYXRVopoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2NlE5QDBpPkKxOlIyQDhyPD;hQi=>
WI38	M4jxNmN6fG:2b4jpZ{BCe3OjeR?=		NEj0enk4OiCq		M{D6TWlEPTB;OD61OkDPxE1?	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ{MUi4NEc,OjF4MkG4PFA9N2F-
HEK293	Ml:zT4lv[XOnIFHzd4F6	M{HhO\|ExOCCwTR?=	MnTLNUBp		MknM[I9meyCwb4SgbY5pcWKrdDDWSWdHNWmwZIXj[YQh[XW2b4Doc5NxcG:{eXzheIlwdiCxZjD0fZJwe2mwZTCxNVc2KHKnc3nkeYUhd25iVlXHSnIzKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJM>	Mli3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6OEWyPFcoRjJzOEi1Nlg4RC:jPh?=
HUVEC	MX3GeY5kfGmxbjDBd5NigQ>?	NVuxRolJOSEQvF2=	Ml7CNlQhcA>?		M3O1RWFvfGmjbnfpc4dmdmmlIHHjeIl3cXS7IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKF[HR1[tbY5lfWOnZDDj[YxtKG2rZ4LheIlwdg>?	MlPpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkOzNFUoRjJzOU[zN\|A2RC:jPh?=
HUVEC	NYHydlFJTnWwY4Tpc44hSXO\|YYm=	MmK4NUDPxE1?	NHfLNoEyKGh?		MV7Jcohq[mm2aX;uJI9nKEWUSzDwbI9{eGixconsZZRqd25iYYSgWIhzOjB{L2T5dlIxPCCrbjDWSWdHNXO2aX31cIF1\WRiSGXWSWM>	NHzldHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2N\|MxPSd-MkG5OlM{ODV:L3G+
HUVEC	NF;o[lFHfW6ldHnvckBCe3OjeR?=	MnfsNUDPxE1?	M3jSUlEhcA>?		NGjHXmVKdmirYnn0bY9vKG:oIHXOU3MheGixc4Doc5J6dGG2aX;uJIF1KFOncj2xNVczKGmwIG\FS2Yue3SrbYXsZZRm\CCKVW\FRy=>	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4M{OwOUc,OjF7NkOzNFU9N2F-
HUVEC	MkjFT4lv[XOnIFHzd4F6	NIXZ[28yKM7:TR?=	MXuxJIg>		M3TRXWlvcGmkaYTpc44hd2ZiVlXHSnIzKHCqb4PwbI9zgWyjdHnvckBifCC2eYKtNVE4PSCrbjDWSWdHNXO2aX31cIF1\WRiSGXWSWM>	M4LaTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[zN\|A2Lz5{MUm2N\|MxPTxxYU6=
HUVEC	MkDnSpVv[3Srb36gRZN{[Xl?	Mo\MNUDPxE1?	MlfwNUBp		Ml22[I9meyCwb4SgbY5pcWKrdDDBT3QheGixc4Doc5J6dGG2aX;uJIF1KFOncj20O\|MhcW5iVlXHSk1{fGmvdXzheIVlKEiXVlXD	NI\ye289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2N\|MxPSd-MkG5OlM{ODV:L3G+
HL60	MV;DfZRwfG:6aXOgRZN{[Xl?	MXq1NEDPxE1?	MlHuOFghcA>?	Mme3SG1UVw>?	NH;MUYJKSzVyPUG1MlUh\|ryP	NXHnepNuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNVkyQDhpPkKyNFE6OTh6PD;hQi=>
K562	MUfDfZRwfG:6aXOgRZN{[Xl?	MWK1NEDPxE1?	NGLCcIY1QCCq	NVzR[HAxTE2VTx?=	MVvJR\|UxRTJzLkmg{txO	NWLROnNvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNVkyQDhpPkKyNFE6OTh6PD;hQi=>
PC3	NWHiXo9FS3m2b4TvfIlkKEG\|c3H5	MU[1NEDPxE1?	MXO0PEBp	MYPEUXNQ	MmLETWM2OD1{NT6xJO69VQ>?	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjBzOUG4PEc,OjJyMUmxPFg9N2F-
SF-539	NFPWb25McW6jc3WgRZN{[Xl?	MYWzN\|Mh\|ryP	NIDEOW83OCCvaX6=		MmP5TY5pcWKrdHnvckBw\iCSRFfGVoJmfGFidInyc5NqdmVia3nuZZNmKGGldHn2bZR6KGmwIGDES2YuSkJvc4TpcZVt[XSnZDDoeY1idiCVRj21N\|kh[2WubIOge4l1cCCLQ{WwJI9nKDF{LkKg{txO	NELweJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKwOFc1OSd-MkKyNFQ4PDF:L3G+
HAEC	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmLaNVAxKM7:TR?=	M{Hne\|czKGh?		Mmn1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKQVXDJINmdGy\|IHX4dJJme3OrbnegWmVITlJid3n0bEBKSzVyIH;mJFAvOSEQvF2=	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR2NE[3PUc,OjJ2NES2O\|k9N2F-
HT-29	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEfEe20yODBizszN	MlTWO\|IhcA>?		M1S1eWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOg[ZhxemW\|c3nu[{BXTUeIUjD3bZRpKEmFNUCgc4YhOC5\|MzFOwG0>	M1LhR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NES0Olc6Lz5{MkS0OFY4QTxxYU6=
MV4-11	NFjacWtEgXSxdH;4bYMhSXO\|YYm=		MVK3NkBp		NHnI[5RKSzVyPUCuNFA{KM7:TR?=	Ml;OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NUK1NVgoRjJ{NEWyOVE5RC:jPh?=
HepG2	M{PlfGN6fG:2b4jpZ{BCe3OjeR?=		M2PQUFQ5KGh?		NE\wUFNKSzVyPUGzMlI1KM7:TR?=	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR6M{[wPEc,OjJ2OEO2NFg9N2F-
PC9	MXTDfZRwfG:6aXOgRZN{[Xl?		NFHpV4Y1QCCq		NE\iVm5KSzVyPUGwMlk4KM7:TR?=	NV3tbYRHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFM3ODhpPkKyOFg{PjB6PD;hQi=>
CAKI-1	NHzCUWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlPwNVAxKM7:TR?=	Mn7jOFghcA>?	NH;4OJRFVVOR	NXjX[Gd4T0l3ME2wMlY{KM7:TR?=	NXvEe2NqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OlA3OjdpPkKyOVYxPjJ5PD;hQi=>
EKVX	M{\mNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXSxNFAh\|ryP	MmLVOFghcA>?	NHTBXGlFVVOR	M{X4R2dKPTB;Nz65JO69VQ>?	MoPvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3NkC2NlcoRjJ{NU[wOlI4RC:jPh?=
MCF7	MlHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVWxNFAh\|ryP	NHj6TI01QCCq	NUDmW4k6TE2VTx?=	MWLHTVUyRTJizszN	NU\EOZNLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OlA3OjdpPkKyOVYxPjJ5PD;hQi=>
MDA-MB-435	NHWxWIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1HzN\|ExOCEQvF2=	MmLmOFghcA>?	MWPEUXNQ	NIrjdVZIUTV{PUKg{txO	NHvJelg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
OVCAR3	NFjGT5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYWxNFAh\|ryP	MYS0PEBp	NFPvdoNFVVOR	NUTZW29CT0l3M{2zMlIh\|ryP	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
SNB19	M4njXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXnGR\|R7OTByIN88US=>	NF7ESII1QCCq	M2XX[mROW09?	NIjNenRIUTV2PUGwJO69VQ>?	M3LMR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NU[wOlI4Lz5{MkW2NFYzPzxxYU6=
SW620	Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4n0OVExOCEQvF2=	Mn3LOFghcA>?	NV7GT3B{TE2VTx?=	MWHHTVU2RTFwMzFOwG0>	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV4ME[yO{c,OjJ3NkC2Nlc9N2F-
TK10	NGX2UWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mo\UNVAxKM7:TR?=	MXW0PEBp	MmXjSG1UVw>?	M3jFTmdKPTZ;Nj6zJO69VQ>?	NH;SOIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
UACC257	NGT3XohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXKxNFAh\|ryP	MonGOFghcA>?	NYrSc2ZUTE2VTx?=	NXnBV3ZvT0l3N{20JO69VQ>?	NEXndZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW2NFYzPyd-MkK1OlA3Ojd:L3G+
HAEC	NYrRd\|ZUS3m2b4TvfIlkKEG\|c3H5	M4PWVFExOCEQvF2=	MnzmO\|IhcA>?	MonySG1UVw>?	M{\wdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KF[HR1\SJIV5eHKnc4PpcochUEGHQzD3bZRpKEmFNUCgc4YhOC5zIN88US=>	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF\|MUW0NUc,OjNzM{G1OFE9N2F-
HT-29	MVjDfZRwfG:6aXOgRZN{[Xl?	MkXFNVAxKM7:TR?=	NG\TfW04OiCq	MlfVSG1UVw>?	NEL6NJREgXSxdH;4bYNqfHliYXfhbY5{fCCYRVfGVkBmgHC{ZYPzbY5oKGi3bXHuJGhVNTJ7IHPlcIx{KHerdHigTWM2OCCxZjCwMlM{KM7:TR?=	Mn3JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzM{G1OFEoRjJ\|MUOxOVQyRC:jPh?=
HCT116	MVHGeY5kfGmxbjDBd5NigQ>?		M3j6NFI1KGh?	M1nlcWROW09?	MWHBcpRqdWmpcnH0c5J6KGGldHn2bZR6KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDtbYdz[XSrb36=	MmnMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNUOyNFAoRjJ\|MUWzNlAxRC:jPh?=
HUVEC	NVj2[VJKTnWwY4Tpc44hSXO\|YYm=	M2nBbVIh\|ryP	MVixPEBp	NW\rOYI4TE2VTx?=	NViwSFJsSW62aXHu[4lw\2WwaXOgZYN1cX[rdImgbY4hUFWYRVPzJJVv\GW{IHj5dI95cWNiY3;u[Il1cW:wIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidIXi[UBnd3KvYYTpc44>	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF3M{KwNEc,OjNzNUOyNFA9N2F-
ACHN	NF7ze\|REgXSxdH;4bYMhSXO\|YYm=		NGHpUlM3KGR?		MmTPTWM2OD1{LkWg{txO	NXmyfYF1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzOlAyODRpPkKzN\|YxOTB2PD;hQi=>
A498	Mmr2R5l1d3SxeHnjJGF{e2G7	MlLaNVAxKM7:TR?=	M4L3Z\|czKGh?	NGXaNVFFVVOR	MUDJR\|UxRTRwMzFOwG0>	NWDNWmloRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PFk3OjZpPkKzOFg6PjJ4PD;hQi=>
HUVEC	M2f6N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnzRN{DPxE1?	M1ruRlI1KGh?	NFntbnNFVVOR	NVLENmpjSW62aXHu[4lw\2WwaXOgZYN1cX[rdImgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDWSWdHNWmwZIXj[YQhfHWkZTDmc5Ju[XSrb36ge4l1cCCHQ{WwJI9nKDBwNkS1JO69VQ>?	NF;1fJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W4N\|kyOSd-MkO1PFM6OTF:L3G+
HUVEC	MlPKT4lv[XOnIFHzd4F6	MoLONlAxKM7:TR?=		NXP3XotETE2VTx?=	MUXJcohq[mm2aX;uJI9nKF[HR1\SNkBxcG:\|cHjvdplt[XSrb36gbY4h\3Kxd4ToJIZi[3Sxcj3zeIlufWyjdHXkJGhWXkWF	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV6M{mxNUc,OjN3OEO5NVE9N2F-
HUVEC	NH\hNXdMcW6jc3WgRZN{[Xl?	Mn;ENlAxKM7:TR?=		NV;OS4RxTE2VTx?=	MV\Jcohq[mm2aX;uJI9nKF[HR1\SNUBxcG:\|cHjvdplt[XSrb36gbY4h\3Kxd4ToJIZi[3Sxcj3zeIlufWyjdHXkJGhWXkWF	NFexd4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W4N\|kyOSd-MkO1PFM6OTF:L3G+
A549	M2T0d2N6fG:2b4jpZ{BCe3OjeR?=		M{PhelczKGh?	NIjle4tFVVOR	NGLtcoZKSzVyPUKuOFQh\|ryP	NVHOdFJWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NFI1PDFpPkKzOlAzPDRzPD;hQi=>
HCT116	MljhR5l1d3SxeHnjJGF{e2G7		MY[3NkBp	NI\FNHdFVVOR	MXfJR\|UxRTRwN{Gg{txO	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMkS0NUc,OjN4MEK0OFE9N2F-
MCF7	M4L4PGN6fG:2b4jpZ{BCe3OjeR?=		M{\UUlczKGh?	NWK5N4tUTE2VTx?=	MXTJR\|UxRTZwMkmg{txO	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMkS0NUc,OjN4MEK0OFE9N2F-
BGC	NVewTmdlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		Mn3oO\|IhcA>?	NG\t[VZFVVOR	MVPJR\|UxRTRwN{ig{txO	NHLtUlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m5PVA1OCd-MkO5PVkxPDB:L3G+
BxPC3	NIHwSlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NXrGUJpuPzJiaB?=	Mn\vSG1UVw>?	MYDJR\|UxRTNwNkOg{txO	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl7OUC0NEc,OjN7OUmwOFA9N2F-
HT-29	NWTjNWJuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MYm3NkBp	NX7pO\|ZVTE2VTx?=	M{HTSmlEPTB;MT60O{DPxE1?	Ml20QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7OUmwOFAoRjJ\|OUm5NFQxRC:jPh?=
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4T1	NVLi[IxXS3m2b4TvfIlkKEG\|c3H5		MVG3NkBp	NH;EUm5FVVOR	M2TOT2lEPTB;MD6wNVYh\|ryP	NFfoRYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MCF7	NUjUemxnS3m2b4TvfIlkKEG\|c3H5		NW\CcY5QPzJiaB?=	NWmxVWVITE2VTx?=	M{\YeGlEPTB;MD6wNlcyKM7:TR?=	Mn7lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
MCF7	MXHDfZRwfG:6aXOgRZN{[Xl?		NELnemo4OiCq	MVXEUXNQ	NGXNeZlKSzVyPUCuNFI6OyEQvF2=	NIHDZpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MDA-MB-231	MlvYR5l1d3SxeHnjJGF{e2G7		M4HzXVczKGh?	MWTEUXNQ	MlexTWM2OD1yLkCyNlMh\|ryP	M4XncVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
MDA-MB-435	NVHSeZhHS3m2b4TvfIlkKEG\|c3H5		MXW3NkBp	NGDOWINFVVOR	NFPnbXZKSzVyPUCuNFA6PyEQvF2=	Ml\QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
MDA-MB-468	NEXKb3VEgXSxdH;4bYMhSXO\|YYm=		MWO3NkBp	NFjT[HFFVVOR	NWfmRZhGUUN3ME2wMlAxPjFizszN	M33Bc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
A431	NWHqTIdRU2mwYYPlJGF{e2G7	NXXtOHp3OTBizszN	MVSxJIg>	M3rKOmROW09?	M2D2WmlvcGmkaYTpc44hd2ZiRVfGVkB4cXSqIFnDOVAhd2ZiMD6xO\|IyKM7:TR?=	M1PKWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
SH-SY5Y	MVTLbY5ie2ViQYPzZZk>	NUHMPFdFOTBizszN	Mlj2NUBp	NFT1VHpFVVOR	MmrZTY5pcWKrdHnvckBw\iCSRFfGVoJmfGFid3n0bEBKSzVyIH;mJFAvODh\|MTFOwG0>	MmXNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
U251	NGXV[JpMcW6jc3WgRZN{[Xl?	NEPvdXIyOCEQvF2=	MnyyNUBp	NF61R2dFVVOR	NFHzUnRKdmirYnn0bY9vKG:oIG\FS2ZTOiC5aYToJGlEPTBib3[gNE4xOTh7IN88US=>	MkjTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
Bel7402	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MoLzO\|IhcA>?	NHn5N4dFVVOR	MorSTWM2OD1{Lk[3JO69VQ>?	M{jXSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
HK2	MmX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NHzHXog4OiCq	Mlu5SG1UVw>?	NFzZT2JKSzVyPUWuPFUh\|ryP	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2NUc,OjR7MES5OlE9N2F-
LO2	NXjRUm5NT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NXryOWE{PzJiaB?=	M{O0Z2ROW09?	Mn72TWM2OD1zOT65N{DPxE1?	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2NUc,OjR7MES5OlE9N2F-
MV4-11	M{fI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MnnZOFghcA>?	NWXBcW44TE2VTx?=	NGPrWJhKSzVyPUCuNFA{KM7:TR?=	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2NUc,OjR7MES5OlE9N2F-
NCI-H3122	M1z3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NFznb5A4OiCq	MljtSG1UVw>?	NWjMTppnUUN3ME2wMlg{KM7:TR?=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyNEm2NUc,OjR7MES5OlE9N2F-
NCI-H460	NYfySHZNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MXq3NkBp	Ml;QSG1UVw>?	MV\JR\|UxRTRwM{Gg{txO	M1i1ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
NCI-H526	NGfrV2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		Mlf2O\|IhcA>?	NGTlRZlFVVOR	NXzZfmRCUUN3ME2xMlAyKM7:TR?=	M3vOeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUC0PVYyLz5{NEmwOFk3OTxxYU6=
TT	NWHMRopET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MUS3NkBp	M2r6SGROW09?	M1[2W2lEPTB;MD6wOEDPxE1?	NWXZO\|JURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFQ6PjFpPkK0PVA1QTZzPD;hQi=>
3T3	M3f5XGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NHryVIE4OiCqcoO=		NHvuSINCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIEPUN{Bk\WyuczDlfJBz\XO\|aX7nJIh2dWGwIFPTSlFTKGGodHXyJFczKGi{czDifUBE\WyudHn0[ZIh[XO\|YYmsJGFkfGm4aYT5JF0hOC5yOTFOwG0v	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ7NE[0NUc,OTh4OUS2OFE9N2F-
MV4-11	NIflOodCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NUDwe2cyPzJiaILz		MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2YND2xNUBk\WyuczDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMD6wNFQ{KM7:TT6=	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd3NEG5PUc,OTl5NUSxPVk9N2F-
HEK293	NGjy[3dHfW6ldHnvckBie3OjeR?=				NXPpZ3hiSmmwZHnu[{Bi\m[rbnn0fUB1dyCITGSzJINifGGueYTpZ{Bld22jaX6g[ZhxemW\|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBkd22yZYTpeIl3\SCkaX7kbY5oKGG\|c3H5MEBM\CB;IECuNFAxPDdizszNMi=>	M3HHS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{W0NVk6Lz5zOUe1OFE6QTxxYU6=
FDC-P1	Mnm0SpVv[3Srb36gZZN{[Xl?		MXq0PEBpenN?		NF3rU3hKdmirYnn0bY9vKG:oIHj1cYFvKE[PUzDlfJBz\XO\|ZXSgbY4h\3Kxd4ToJIZi[3SxcjDk[ZBmdmSnboSgcY92e2ViRlTDMXAyKGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gSm1UNW2nZHnheIVlKGOnbHygdJJwdGmoZYLheIlwdiCrbjDwdoV{\W6lZTDoeY1idiCFU1[xJIFnfGW{IES4JIhzeyCkeTDy[ZNignW{aX6g[JlmKHKnZIXjeIlwdiCjc4PhfUwhUUN3MDC9JFAvOTV3IN88UU4>	NHPsOGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG1OlY5QSd-MkCxOVY3QDl:L3G+
primary leukemia cells	MmXER5l1d3SxeHnjbZR6KGG\|c3H5		MYm3NkBpenN?		NIPLXZNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBxemmvYYL5JIxmfWunbXnhJINmdGy\|IHnzc4xifGWmIH\yc40h[WO3dHWgcZlmdG:rZDDs[ZVs\W2rYTDwZZRq\W62IHX4dJJme3OrbnegSmxVOy2LVFSgcZV1[XSrb36gZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IHz1Z4ln\XKjc3WgZZN{[XluIFnDOVAhRSByLkCzJO69VS5?	NIjGSIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
primary leukemia cells	NHPpcWpEgXSxdH;4bYNqfHliYYPzZZk>		M{W2cFczKGi{cx?=		Mm\6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdJJqdWG{eTDs[ZVs\W2rYTDj[YxteyCrc3;sZZRm\CCocn;tJIFkfXSnIH35[YxwcWRibHX1b4VucWFicHH0bYVvfCCneIDy[ZN{cW6pIIfpcIQhfHmyZTDGUHQ{KGG\|c3Xzd4VlKGG\|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBtfWOrZnXyZZNmKGG\|c3H5MEBKSzVyIE2gNE4xOyEQvF2u	M1:zfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkKxNlAyLz5{MkKyNVIxOTxxYU6=
primary leukemia cells	NV7hSHZlS3m2b4TvfIlkcXS7IHHzd4F6		MVi3NkBpenN?		M4ThOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJBzcW2jcomgcIV2c2WvaXGgZ4VtdHNiaYPvcIF1\WRiZoLvcUBi[3W2ZTDtfYVtd2mmIHzleYtmdWmjIIDheIlmdnRiZYjwdoV{e2mwZzDGUHQ{NUR6M{XZJI12fGG2aX;uJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDseYNq\mW{YYPlJIF{e2G7LDDJR\|UxKD1iMT6xJO69VS5?	MljXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MkGyNFEoRjJ{MkKxNlAyRC:jPh?=
endothelial precursor cells	Mn3nSpVv[3Srb36gZZN{[Xl?				MWXJcohq[mm2aX;uJI9nKGWwZH;0bIVtcWGuIHPvdoQh[XKnYTDmc5Ju[XSrb36gbY4h\W6mb4To[Yxq[WxicILlZ5Vze2:{IHPlcIx{KGK7IFPEN\|Eh[2:{ZDDhdoViKGSndHXjeIlwdiCkYYPl[EBxcGWwb4T5dIlkKGS{dXeg[Il{[2:4ZYL5JIJie2WmIHHzd4F6NCCLQ{WwJF0hOC5yMEm2JO69VS5?	M{fQelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEC5OlY3Lz5{MkSwPVY3PjxxYU6=
endothelial precursor cells	NYLTUmhTTnWwY4Tpc44h[XO\|YYm=				NEDKcVNKdmirYnn0bY9vKG:oIHPlcIwhdWmpcnH0bY9vKGmwIHXu[I91cGWuaXHsJJBz\WO3coPvdkBk\WyuczDifUBQemm\|IHPlcIwhdWmpcnH0bY9vKGurdDDiZZNm\CCyaHXuc5R6eGmlIHTyeYch\Gm\|Y3;2[ZJ6KGKjc3XkJIF{e2G7LDDJR\|UxKD1iMUOuOkDPxE1w	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjRyOU[2Okc,OjJ2MEm2OlY9N2F-
U251	NVH5PVl5TnWwY4Tpc44h[XO\|YYm=		NVrlOGFTPjBibXnudy=>		Mn3oTY5pcWKrdHnvckBw\iCYRVfGVlIhcW5iaIXtZY4hXTJ3MTDj[YxteyCycnX0doVifGWmIH\vdkA3OCCvaX7zJI1m[XO3cnXkJIFnfGW{IEGgbJIh[nliRVzJV2EtKEmFNUCgQUAyQC57IN88UU4>	NUL5XJBtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3N\|kxQTBpPkKyO\|M6ODlyPD;hQi=>
U251	NFXlRVVHfW6ldHnvckBie3OjeR?=		NVvoUYYzPjBibXnudy=>		MoHhTY5pcWKrdHnvckBw\iCYRVfGMYlv\HWlZXSgWmVITlJ{IIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCXMkWxJINmdGy\|IH;2[ZJmgHC{ZYPzbY5oKE[uaz2xJJBz\XS{ZXH0[YQh\m:{IE[wJI1qdnNicILpc5IhfG9iVlXHSkBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjCxNEBucW6\|IHL5JJBpd3OyaH;0fZJwe2mwZTDFUGlUSSCleYTvZoxwfCCjbnHsfZNqeyxiSVO1NEA:KDF6Lkmg{txONg>?	NGrmZVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O3OVA6OCd-MkOzO\|UxQTB:L3G+
U251	NHKzXIVHfW6ldHnvckBie3OjeR?=		MlvpOlAhdWmwcx?=		NXrVbXhkUW6qaXLpeIlwdiCxZjDWSWdHWjJiaX6gbJVu[W5iVUK1NUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIG\FS2YucW6mdXPl[EB1gXKxc3nu[UBxcG:\|cHjvdplt[XSrb36gbY5kfWKjdHXkJIZweiB4MDDtbY5{KHC{aX;yJJRwKF[HR1[tZYN1cX[jdHnvckBu\WG\|dYLl[EAyOCCvaX7zJIJ6KEWOSWPBMEBKSzVyIE2gNVgvQSEQvF2u	NWjue3ZmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0N\|QyOzlpPkKzOFM1OTN7PD;hQi=>
CHO	MkWySpVv[3Srb36gZZN{[Xl?				MUPJcohq[mm2aX;uJI9nKEOjdkGuNkBkfXK{ZX70JI1m[XO3cnXkJJV{cW6pIGHQZZRkcCCjdYTvcYF1cWNicHH0bEBkdGGvcDDzfZN1\W1iaX6gR2hQKGOnbHzzJIV5eHKnc4PpcochS2G4MT6yMEBj\XSjLUKgZY5lKGGucHjhMVIw\GWudHGtNUB{fWK3bnn0d{whUUN3MDC9JFM{NjRizszNMi=>	NH:4Spo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ixNlUxOyd-MkO4NVI2ODN:L3G+
U251	NIrNU3VHfW6ldHnvckBie3OjeR?=				NXXqVVV2UW6qaXLpeIlwdiCxZjDWSWdHWjJiaX6gbJVu[W5iVUK1NUBk\WyuczDifUBxcG:\|cHjveJlzd3OrbnWgSWxKW0FuIFnDOVAhRSByLkCxPFkh\|ryPLh?=	NEnXbGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFg3PSd-MkS5NFA5PjV:L3G+
MCF7	NUXaTpJRSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M4PxUVQ5KGi{cx?=		MmLORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPQ1[3JINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMD61JO69VS5?	NHvWUpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC2OFM1Pyd-MkWwOlQ{PDd:L3G+
HepG2	MX\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NHXpZ4I1QCCqcoO=		M1O1bmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS\|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGzMlYh\|ryPLh?=	M1XJPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3ME[0N\|Q4Lz5{NUC2OFM1PzxxYU6=
CHO	NUfVO4tSTnWwY4Tpc44h[XO\|YYm=				NXLReZBCUW6qaXLpeIlwdiCxZjDyZZBq\CCmZXzhfYVlKGmwd3Hy[EBz\WO2aX\5bY5oKHCxdHHzd4l2dSCldYLy[Y51KCiLS4KpJIlvKEOqaX7ld4UhcGGvc4TldkBwfmG{eTCoR2hQMSClZXzsd{B{fGGkbHWg[ZhxemW\|c3nu[{BpTVKJIH3lZZN2emWmIIXzbY5oKEmxbmfvdot{KEKjcoLhZ5Vl[SCjdYTvcYF1\WRicHH0Z4gh[2yjbYCgdIxifG[xcn2sJGlEPTBiPTC3Mlk1OzJ6IN88UU4>	MkT5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEe3OVMoRjJ3MEi3O\|U{RC:jPh?=
CHO K1	NWTyT\|g1TnWwY4Tpc44h[XO\|YYm=				NGrZRWVKdmirYnn0bY9vKG:oIILhdIllKGSnbHH5[YQhcW65YYLkJJJm[3SrZonpcocheG:2YYPzbZVuKGO3coLlcpQhMEmNcjmgbY4hS2irbnXz[UBp[W2\|dHXyJI93[XK7IDjDTG8qKEtzIHPlcIx{KHO2YXLsfUBmgHC{ZYPzbY5oKGiHUlegcYVie3W{ZXSgeZNqdmdiSX;uW49zc3NiUYXheJRzdyCjdYTvcYF1\WRicHH0Z4gh[2yjbYCgdIxifG[xcn2sJGlEPTBiPTCxNEDPxE1w	NHvufWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4O\|c2Oyd-MkWwPFc4PTN:L3G+
CHO K1	MVjGeY5kfGmxbjDhd5NigQ>?				NYnjUJM5UW6qaXLpeIlwdiCxZjDmZZN1KHOxZHn1cUBkfXK{ZX70JEhKVmFrIHnuJGNpcW6nc3WgTIFue3SncjDPeoFzgSBqQ1jPLUBMOSClZXzsd{B1emGwc3\lZ5Rm\CC5aYToJIh2dWGwIF7helEvPSCvZXHzeZJm\CC3c3nu[{BKd26Zb4Lrd{BSfWG2dILvJIF2fG:vYYTl[EBx[XSlaDDjcIFueCCybHH0[o9zdSxiSVO1NEA:KDF3Lki0PFkh\|ryPLh?=	MmfkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEe3OVMoRjJ3MEi3O\|U{RC:jPh?=
HEK293	NH61WG5HfW6ldHnvckBie3OjeR?=				NVy3eGs1UW6qaXLpeIlwdiCxZjDmZZN1KHOxZHn1cUBkfXK{ZX70JEhKVmFrIHnuJGhGUzJ7MzDj[YxteyC2cnHud4Zm[3SnZDD3bZRpKGi3bXHuJG5ifjFwNTDt[YF{fXKnZDD1d4lv\yCLb37Xc5JseyCTdXH0eJJwKGG3dH;tZZRm\CCyYYTjbEBkdGGvcDDwcIF1\m:{bTygTWM2OCB;IEO5MlgyODdizszNMi=>	NWD4N5ExRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPFc4PTNpPkK1NFg4PzV\|PD;hQi=>
MOLM13	M1\CUWN6fG:2b4jpZ4l1gSCjc4PhfS=>		M{LRXFQ5KGi{cx?=		M4OzbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1QVE1zMzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMUe3JO69VS5?	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB6OUixNEc,OjVyOEm4NVA9N2F-
MV4-11	NEDae2dEgXSxdH;4bYNqfHliYYPzZZk>		MXi0PEBpenN?		MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODJ2MzFOwG0v	NGDi[Fc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4PVgyOCd-MkWwPFk5OTB:L3G+
HL60	MnHQR5l1d3SxeHnjbZR6KGG\|c3H5		M3LNWlQ5KGi{cx?=		MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlA{PjhizszNMi=>	NXu0eIxKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPFk5OTBpPkK1NFg6QDFyPD;hQi=>
THP1	MUHDfZRwfG:6aXPpeJkh[XO\|YYm=		MnzqOFghcHK\|		NYXLPHpRS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXEiSMTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yNEW3JO69VS5?	MkHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOEm4NVAoRjJ3MEi5PFExRC:jPh?=
ACHN	NEK3cIVEgXSxdH;4bYNqfHliYYPzZZk>		Mmf1O\|IhcHK\|		M3LpSGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGFEUE5iY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIh\|ryPLh?=	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTF{NEGxOEc,OjVzMkSxNVQ9N2F-
U251	MUXGeY5kfGmxbjDhd5NigQ>?		M{HXUFYxKG2rbh?=		NY\Rblk6UW6qaXLpeIlwdiCxZjDWSWdHWjJiaX6gbJVu[W5iVUK1NUBk\WyuczDjc41xd3WwZDDwdoV1emWjdHXkJIZweiB4MDDtbY4h[mWob4LlJHZGT0Zic4TpcZVt[XSrb36g[o9zKDFyIH3pcpMh[nlicHjvd5Bpd3S7cn;zbY5mKEWOSWPBJIN6fG:kbH;0JI1mfGixZDygTWM2OCB;IECuNFE5QSEQvF2u	MnXjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6OEK1NVkoRjJ3OEiyOVE6RC:jPh?=
U251	Mn\iSpVv[3Srb36gZZN{[Xl?		MnrvOlAhdWmw		M{CwUmlvcGmkaYTpc44hd2ZiUFTHSnIu[mW2YTDpckBpfW2jbjDVNlUyKGOnbHzzJINwdXCxdX7kJJBz\XS{ZXH0[YQh\m:{IE[wJI1qdiCkZX\vdoUhWESJRj3CRkB{fGmvdXzheIlwdiCob4KgNVAhdWmwczDifUBxcG:\|cHjveJlzd3OrbnWgSWxKW0FiY4n0c4Jtd3RibXX0bI9lNCCLQ{WwJF0hOC5yOEOxJO69VS5?	M1HaflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEiyOVE6Lz5{NUi4NlUyQTxxYU6=
A431	NV7PO2twTnWwY4Tpc44h[XO\|YYm=		NWLRNGtQPjBibXnu		MlHPTY5pcWKrdHnvckBw\iCHR1\SJIlvKGi3bXHuJGE1OzFiY3XscJMh[2:vcH;1coQheHKndILlZZRm\CCob4KgOlAhdWmwIHLl[o9z\SCHR1[gd5RqdXWuYYTpc44h\m:{IEGwJI1qdnNiYomgdIhwe3Cqb4T5do9{cW6nIFXMTXNCKGO7dH;icI91KG2ndHjv[EwhUUN3MDC9JFAvOTd{MTFOwG0v	Mn\wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6OEK1NVkoRjJ3OEiyOVE6RC:jPh?=
HT-29	MWLDfZRwfG:6aXPpeJkh[XO\|YYm=		NFXHWnM1QCCqcoO=		MlLhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR\|UxKD1iND63JO69VS5?	NVLWbmloRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wNFkyPjRpPkK2NFA6OTZ2PD;hQi=>
A549	Mn7tR5l1d3SxeHnjbZR6KGG\|c3H5		NVjzUGh2PDhiaILz		NIHETZhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEeuPVMh\|ryPLh?=	NH\0XVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwPVE3PCd-Mk[wNFkyPjR:L3G+
SKOV3	MXjDfZRwfG:6aXPpeJkh[XO\|YYm=		M{\Bd\|Q5KGi{cx?=		NFXtWVlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTBiPTC5MlIyKM7:TT6=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjByOUG2OEc,OjZyMEmxOlQ9N2F-
PANC1	Mlf6R5l1d3SxeHnjbZR6KGG\|c3H5		Mm[3OFghcHK\|		NXvkXGNUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEGQQ{GgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG\|c3H5MEBKSzVyIE2gNVQvQTRizszNMi=>	NF7NTpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCwPVE3PCd-Mk[wNFkyPjR:L3G+
HepG2	NHL1eHdEgXSxdH;4bYNqfHliYYPzZZk>		MXm0PEBpenN?		MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSBzNj6wOkDPxE1w	MoS2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEmxOlQoRjJ4MEC5NVY1RC:jPh?=
MCF7	MX;DfZRwfG:6aXPpeJkh[XO\|YYm=		Ml\VOFghcHK\|		MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDJ3LkSxJO69VS5?	NXPwUmkyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wNFkyPjRpPkK2NFA6OTZ2PD;hQi=>
Bel7402	MUnQbI91d2O7dH;0c5hq[2m2eTDhd5NigQ>?		MlzUOUBpenN?		Mk\UVIhwfG:leYTveI95cWOrdImgZYdicW6\|dDDoeY1idiCEZXy3OFAzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JJBz\WmwY4XiZZRm\CCob4KgOUBpenNid3n0bEBk\WyuczDmc4xtd3enZDDifUBWXkFvMTDpdpJi\GmjdHnvckBifCB\|LkCgcXcw[21pMjDmc5IhOjBibXnud{Bu\WG\|dYLl[EBi\nSncjC0PEBpenNiYomgR2NMQCCjc4PhfUwhTUN3MDC9JFEyKM7:TT6=	NGn2fpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW4OFA5PSd-Mk[1PFQxQDV:L3G+
PANC1	NXzl[4RjWGixdH;jfZRwfG:6aXPpeJkh[XO\|YYm=		M4fuVVUhcHK\|		NIHkVWZRcG:2b3P5eI91d3irY3n0fUBi\2GrboP0JIh2dWGwIGDBUmMyKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JJBz\WmwY4XiZZRm\CCob4KgOUBpenNid3n0bEBk\WyuczDmc4xtd3enZDDifUBWXkFvMTDpdpJi\GmjdHnvckBifCB\|LkCgcXcw[21pMjDmc5IhOjBibXnud{Bu\WG\|dYLl[EBi\nSncjC0PEBpenNiYomgR2NMQCCjc4PhfUwhTUN3MDC9JFE{KM7:TT6=	MnHyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OESwPFUoRjJ4NUi0NFg2RC:jPh?=
SVEC4-10	NF7QWlFEgXSxdH;4bYNqfHliYYPzZZk>		NGrT[mczPCCqcoO=		NUjST3RMS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhW1[HQ{StNVAh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IEig{txONg>?	NHfNXJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkmxNlEyOSd-Mk[5NVIyOTF:L3G+
HUVEC	NIfIUXhCdnSrYX7nbY9o\W6rYzDhd5NigQ>?	MkPFNVAhfU1?	MoLsOUBpenN?		M363TWFvfGmjbnfpc4dmdmmlIHHjeIl3cXS7IHnuJIh2dWGwIFjVWmVEKGOnbHzzJIF{e2W\|c3XkJIF{KGGwZ3nv[4Vv\XOrczDyZZRmKGG2IEGwJJVOKGGodHXyJFUhcHK\|IHL5JIVv\G:2aHXsbYFtKHS3YnWg[o9zdWG2aX;uJIF{e2G7IILlcIF1cX[nIITvJINwdnS{b3y=	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjlzMkGxNUc,OjZ7MUKxNVE9N2F-
HT-29	NWDReJJES3m2b4TvfIlkcXS7IHHzd4F6				NWLLN3BDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNU44KM7:TT6=	M1HKV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUKwPFAxLz5{NkmyNFgxODxxYU6=
A549	NHzWTYNEgXSxdH;4bYNqfHliYYPzZZk>				M3jjdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iOT6xJO69VS5?	M4izRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUKwPFAxLz5{NkmyNFgxODxxYU6=
MDA-MB-435	M{DKXGN6fG:2b4jpZ4l1gSCjc4PhfS=>				M3LQPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20N\|Uh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS5\|IN88UU4>	NYD3XYVsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5NlA5ODBpPkK2PVIxQDByPD;hQi=>
MV4-11	MofvRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NFnXZZo4OiCqcoO=		MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IF\MWFMuUVSGIHTldIVv\GWwdDDoeY1idiCPVkStNVEh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCwMlAxOSEQvF2u	MmGwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
HL60	NWnqbVZZSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NIf1R444OiCqcoO=		M2PifmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNFAyKM7:TT6=	MoPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
BAF3	M4ryZWZ2dmO2aX;uJIF{e2G7		MXW3NkBpenN?		M3LsWmlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhXDZ5MFmgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8wS0ONODDhd5NigSxiR1m1NEA:KDBwMECyJO69VS5?	NIT6NpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
MOLM14	NWjldIlpSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M4S4ZVczKGi{cx?=		NUHGTmZmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBHVFR\|LVnUSEBl\XCnbnTlcpQhcHWvYX6gUW9NVTF2IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5yMEWg{txONg>?	NEfXcoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BAF3	MkDmSpVv[3Srb36gZZN{[Xl?		NUHTUZRsPzJiaILz		MYjJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJHY2PTmGL2[2OVRCKGSxdXLs[UBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFYh\|ryPLh?=	NF;HVYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BAF3	NEfwe5NHfW6ldHnvckBie3OjeR?=		NHO5XWc4OiCqcoO=		M2HIOWlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhXjV3OVSgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8wS0ONODDhd5NigSxiR1m1NEA:KDBwMEC5JO69VS5?	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BAF3	M4XwcWZ2dmO2aX;uJIF{e2G7		MlzsO\|IhcHK\|		Mmr3TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBXPjV2QTDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5yMjFOwG0v	NInueHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BAF3	MmjrSpVv[3Srb36gZZN{[Xl?		M2HEZVczKGi{cx?=		MnfZTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBNPTZ5UDDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5yMkOg{txONg>?	NYLuR2FTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
GISTT1	MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MUK3NkBpenN?		M{m5WmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgZ2tKXCCmZYDlcoRmdnRiaIXtZY4hT0mVVGSxJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6wOFEh\|ryPLh?=	NF7xNpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BAF3	NVLIb4c2TnWwY4Tpc44h[XO\|YYm=		MXO3NkBpenN?		Mn3nTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBVPjdyST;WOVU6TCCmb4XicIUhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG\|ZTDpckBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNFU{KM7:TT6=	M2\YbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
BAF3	M16xTmZ2dmO2aX;uJIF{e2G7		M{XzW\|czKGi{cx?=		NE\YdldKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjT2lVKCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFAvODd6IN88UU4>	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
GIST882	NVPRVXBkSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MYO3NkBpenN?		NIXRXpdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JINMUVRiZHXw[Y5l\W62IHj1cYFvKEeLU2S4PFIh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCwMlEyKM7:TT6=	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BAF3	NY\hNXVwTnWwY4Tpc44h[XO\|YYm=		NVPZSW5RPzJiaILz		NVvNVo11UW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgZ2tKXCCQOEKyT{BufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD61NUDPxE1w	MoTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
Rec1	NHThZlNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NWnlR4gzPzJiaILz		MonDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCUZXOxJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD64O{DPxE1w	NFXzS2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
K562	NFOzRmVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MV63NkBpenN?		NFPGb2NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGJEWi2DQlyg[IVx\W6mZX70JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCxJO69VS5?	M2Hj[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
KU812	NV2zVXRmSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M2H2dlczKGi{cx?=		MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFLDVk1CSkxiZHXw[Y5l\W62IHj1cYFvKEuXOEGyJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMT6xJO69VS5?	M2PBd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
BCR-ABL dependent MEG01	MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NGfFOFg4OiCqcoO=		M2\JV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQlPSMWFDVCCmZYDlcoRmdnRiTVXHNFEh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCxMlIh\|ryPLh?=	NXLEPVNuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
BAF3	M4e3TWZ2dmO2aX;uJIF{e2G7		NIXrdpQ4OiCqcoO=		NXjqNFl2UW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgZ2tKXCCGOEG2WkBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMT6zPEDPxE1w	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
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DU145	MVrDfZRwfG:6aXPpeJkh[XO\|YYm=		NEjHRnI1QCCqcoO=		NWH0UYptS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTZwMzFOwG0v	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ\|OUO2PUc,Ojd4M{mzOlk9N2F-
RWPE1	M1fxZ2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MUi0PEBpenN?		NFfkeGFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBTX1CHMTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPS5{IN88UU4>	NHTYPWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[zPVM3QSd-Mke2N\|k{Pjl:L3G+
L02	MVTDfZRwfG:6aXPpeJkh[XO\|YYm=		M{XnbFczKGi{cx?=		M1XofmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGwxOiClZXzsd{Bi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUA1NjZ{IN88UU4>	NYPLT3BERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2OFM3OzlpPkK3OlQ{PjN7PD;hQi=>
HL60	MlPpR5l1d3SxeHnjbZR6KGG\|c3H5		M1;QWVczKGi{cx?=		NYnBfIUyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB2Lkm1JO69VS5?	MkPFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4NEO2N\|koRjJ5NkSzOlM6RC:jPh?=
U251	NHfITHVHfW6ldHnvckBie3OjeR?=		MUW2NEBucW6\|		MUfJcohq[mm2aX;uJI9nKF[HR1\SMVIhcW5iaIXtZY4hXTJ3MTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hXkWJRjDpcoR2[2WmIIDoc5NxcG:{eXzheIlwdiCycnXpcoN2[mG2ZXSg[o9zKDZyIH3pcpMh\m:ubH;3[YQh[nliVlXHSkBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjCxNEBucW6\|IHL5JGVNUVODIH3leIhw\CxiSVO1NEA:KDBwMEG4PUDPxE1w	NWTORYN1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4PVQ2QDlpPkK3PFk1PTh7PD;hQi=>
SF539	M3LhTWZ2dmO2aX;uJIF{e2G7		M4nzU\|YxKG2rboO=		MXHJcohq[mm2aX;uJI9nKFCGR1\SMYJmfGFiaX6gbJVu[W5iU1[1N\|kh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIGDES2YuSkJiaX7keYNm\CCyaH;zdIhwenmuYYTpc44heHKnaX7jeYJifGWmIH\vdkA3OCCvaX7zJIZwdGyxd3XkJIJ6KFCGR1[tRmIh[WSmaYTpc44hdWWjc4Xy[YQh[W[2ZYKgNVAhdWmwczDifUBGVEmVQTDt[ZRpd2RuIFnDOVAhRSByLkC4N\|Eh\|ryPLh?=	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzh7NEW4PUc,Ojd6OUS1PFk9N2F-
HuH7	MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		M2LVbFQ5KGi{cx?=		NX7uNJUyT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUHWKNzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOy5yMzFOwG0v	M2T4elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUW2N\|Q1Lz5{N{m1OlM1PDxxYU6=
HCT116	NYHaVlB{T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MVq0PEBpenN?		M1u2[Wdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS54MjFOwG0v	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl3NkO0OEc,Ojd7NU[zOFQ9N2F-
SW620	MnnwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		Mly1OFghcHK\|		MV\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTW\|YzOCClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gOk4zPSEQvF2u	NUHCe3NURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OVY{PDRpPkK3PVU3OzR2PD;hQi=>
MV4-11	NITkcmlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NVL3V2JKPzJiaILz		M1;temFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTW[0MVEyKGOnbHzzJIhiemKxcnnu[{BHVFR\|IFnUSEBufXSjboSgZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IECuNFM5PSEQvF2u	M1y0fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEO4N\|I5Lz5{OECzPFMzQDxxYU6=
CHO	NI[1fXNHfW6ldHnvckBie3OjeR?=				NXj1[FVDUW6qaXLpeIlwdiCxZjDoeY1idiCHUleg[ZhxemW\|c3XkJIlvKEOKTzDj[YxteyCkeTDRdIF1[2hiYYPzZZktKEmFNUCgQUAxNjVizszNMi=>	NFXad\|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECzPFMzQCd-MkiwN\|g{Ojh:L3G+
HepG2	MkHZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NF3CVnY1QCCqcoO=		NIfpU\|BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCxOk4xPiEQvF2u	NGX0XJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC1O\|QzOyd-MkiwOVc1OjN:L3G+
MCF7	NV\qbFZHSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MkX0OFghcHK\|		NEL3[phCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK1MlQyKM7:TT6=	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB3N{SyN{c,OjhyNUe0NlM9N2F-
HEK293	NXjwVGlJTnWwY4Tpc44h[XO\|YYm=		MmXYNkBucW6\|		M4[z[GlvcGmkaYTpc44hd2ZiaIXtZY4hV0OWMTDlfJBz\XO\|ZXSgbY4hUEWNMkmzJINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHWydHHr[UBw\iCDU2CrJIFnfGW{IEKgcYlveyCkeTDmcJVwemW\|Y3XuZ4Uh[XO\|YYmsJGlEPTBiPTC2MlEh\|ryPLh?=	M2PmUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkOwPVg2Lz5{OEKzNFk5PTxxYU6=
RCC4	NG\tVopCdnSrY3HuZ4VzKGG\|c3H5		NWPYc2dGPDhiaILz		NYC2eWQ2SW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJHJESzRiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JHhVXCCjc4PhfUwhUUN3MDC9JFQh\|ryPLh?=	NWPZNVNiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNlU3ODBpPkK4N\|I2PjByPD;hQi=>
MDA-MB-231	NFK5O2FCdnSrY3HuZ4VzKGG\|c3H5		NHXZXGs1QCCqcoO=		M3Lp[2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XluIFnDOVAhRSB4IN88UU4>	MlfVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|MkW2NFAoRjJ6M{K1OlAxRC:jPh?=
COLO205	NF3TfZlEgXSxdH;4bYNqfHliYYPzZZk>		M4O2SlI1KGi{cx?=		MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDU2xQOjB3IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA5KM7:TT6=	MmrSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NU[wNlQoRjJ6N{W2NFI1RC:jPh?=
K562	NYC0bW92S3m2b4TvfIlkcXS7IHHzd4F6		MUeyOEBpenN?		NVTnR4NyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTRizszNMi=>	MlfnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NU[wNlQoRjJ6N{W2NFI1RC:jPh?=
MDA-MB-231	MWDDfZRwfG:6aXPpeJkh[XO\|YYm=		M3HyXVI1KGi{cx?=		M2PlbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN\|Eh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOyJO69VS5?	NXG4e3U1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OVYxOjRpPkK4O\|U3ODJ2PD;hQi=>
MDA-MB-231	NE\xZZNEgXSxdH;4bYNqfHliYYPzZZk>		NYi4XHFoOjRiaILz		MYHDfZRwfG:6aXPpeJkhcW5iaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPi57ODFOwG0v	Mme5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NkCzNVMoRjJ6N{[wN\|E{RC:jPh?=
MCF7	NIrqdVVHfW6ldHnvckBie3OjeR?=	M{eyXVQhfU1?	MXqyOEBpenN?		NWHFclJVUW6qaXLpeIlwdiCxZjDWSWdHWjJicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYSgOEB2VSCrbnP1ZoF1\WRiZn;yJFI1KGi{czDifUBY\XO2ZYLuJIJtd3RibXX0bI9l	MnrTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NEKxNVMoRjJ6OUSyNVE{RC:jPh?=
GISTT1	M2XFZ2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MYe3NkBpenN?		NXXtS21{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hT0mVVGSxJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmekeubzDhd5NigSxiR1m1NEA:KDBwMESg{txONg>?	NVm1VG5QRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5PVE1PjVpPkK4PVkyPDZ3PD;hQi=>
GISTT1	MYrDfZRwfG:6aXPpeJkh[XO\|YYm=		MljhO\|IhcHK\|		MlznR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gS2lUXFRzIHPlcIx{KGijcnLvdolv\yCNSWSgWFY4OElibYX0ZY51KGG\|c3Xzd4VlKGG\|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldmdtdyCjc4PhfUwhT0l3MDC9JFAvODlizszNMi=>	M3rxNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUmxOFY2Lz5{OEm5NVQ3PTxxYU6=
GIST430	NGHJVotEgXSxdH;4bYNqfHliYYPzZZk>		NXXsc4o5PzJiaILz		NHn0[pBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBIUVOWNEOwJINmdGy\|IHjhdoJwemmwZzDLTXQhXjZ3NFGgcZV1[W62IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmekeubzDhd5NigSxiR1m1NEA:KDBwMEm4JO69VS5?	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl7MUS2OUc,Ojh7OUG0OlU9N2F-
GISTT1	NIHt[3NEgXSxdH;4bYNqfHliYYPzZZk>		MofiO\|IhcHK\|		MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDHTXNVXDFiY3XscJMhcGG{Yn;ybY5oKEuLVDDEPFE3TSCvdYThcpQh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyS4xwKGG\|c3H5MEBIUTVyIE2gOU45QCEQvF2u	Mm\KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7OUG0OlUoRjJ6OUmxOFY2RC:jPh?=
HuH7	M4G3UmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MXO0PEBpenN?		M3LvdmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSIXIO{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iND63NFch\|ryPLh?=	NEi3UG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC1O\|A1Oid-MkmwOVcxPDJ:L3G+
A498	M2TRbmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NInvdJM1QCCqcoO=		Mnn5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDNEm4JINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5Lkm4NUDPxE1w	NX;adHhJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwOVcxPDJpPkK5NFU4ODR{PD;hQi=>
NCI-H727	M{T2VmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M1\wXVQ5KGi{cx?=		MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3IO\|I4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCxNE4yOiEQvF2u	MlrJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyNUewOFIoRjJ7MEW3NFQzRC:jPh?=
MV4-11	NGHCeFFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NFT5PJI4OiCqcoO=		NYqxcYh2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGy2aYTldk1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjBzIN88UU4>	MnnLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7M{W3O\|IoRjJ7OUO1O\|czRC:jPh?=
HuH7	NVqwWmw1SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=				MlnrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKdVi3JINmdGy\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMvODNizszNMi=>	NV36S49JRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOVk5ODNpPkOwNFU6QDB\|PD;hQi=>
HCT116	MVLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?				M3j4VWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwNkKg{txONg>?	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB3OUiwN{c,OzByNUm4NFM9N2F-
SW620	NGPwbZVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=				M3fuRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2e2NlAh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPi5{NTFOwG0v	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB3OUiwN{c,OzByNUm4NFM9N2F-
HepG2	MkX4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?				M3rMbmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS\|Ih[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPy55ODFOwG0v	MkLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNUm4NFMoRjNyMEW5PFA{RC:jPh?=
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no-10	M17u[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWTJR\|UxRTJzLkCyOlQh\|ryP	NFzHPHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
GDM-1	NGm1eXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkLYTWM2OD1{MT65OFE1KM7:TR?=	NXjFNZV5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
KMS-12-PE	M2fwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYTJR\|UxRTJ{LkK3OEDPxE1?	NYLnZXBERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-H510A	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn3kTWM2OD1{ND6xNlc5KM7:TR?=	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
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NMC-G1	Mn:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGO5emxKSzVyPUK3MlE5OjJizszN	NVrZOFZERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
NCI-H446	NG[3b4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2X1eGlEPTB;MkeuOFk1PiEQvF2=	MnzYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NB7	NHm4c5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHvLXnNKSzVyPUK3MlkzOjlizszN	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
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JVM-2	NGPofodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mn3WTWM2OD1{OD6yPFk5KM7:TR?=	M4\vfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
HT-144	NH;PTJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHy1WnhKSzVyPUK4MlY6KM7:TR?=	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
NCI-H747	NHLSOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1H1e2lEPTB;MkiuPVE6PSEQvF2=	NETYOoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
NCI-H1650	MnTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2[wdWlEPTB;MkmuNFE4PiEQvF2=	MnHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
EB-3	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnrwTWM2OD1{OT61N\|A6KM7:TR?=	M3zlbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
KLE	M{\QWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXz3XGc4UUN3ME2yPU43OTlizszN	NEP2do49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
TK10	NFfjUmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmLOTWM2OD1\|MD6xNlYh\|ryP	M4\hSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
COLO-668	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUnJR\|UxRTNyLke5NkDPxE1?	M2qwfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
NCI-H23	NX;5WHZYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MojXTWM2OD1\|MT6xNFY{KM7:TR?=	NHzoTHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
GOTO	Mo\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3PtUmlEPTB;M{GuOlA5PSEQvF2=	M37Ie\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
MSTO-211H	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmrsTWM2OD1\|MT64Olc5KM7:TR?=	M3\zVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
LB831-BLC	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoT2TWM2OD1\|Mj6zPFQ{KM7:TR?=	M{POW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
SCH	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX\JR\|UxRTN{Lki0PFUh\|ryP	M2LBZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
EHEB	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVTJR\|UxRTN2LkGxPVMh\|ryP	M12yfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
U-266	MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIP0eItKSzVyPUO0MlI4QDFizszN	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
EW-11	NFG0XolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlzrTWM2OD1\|ND60O\|I2KM7:TR?=	M2jZflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PS9pPmPBUmdGWjxxYU6=
TE-9	M2LFSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWHJR\|UxRTN5LkC0NFEh\|ryP	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
ES3	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlzXTWM2OD1\|Nz61NFA1KM7:TR?=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
NCI-H2141	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIm4Z2tKSzVyPUO4MlA5PDNizszN	NYfjWVVuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
MPP-89	M1PSWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3;SXWlEPTB;NEKuNFU5PiEQvF2=	NGfOT3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
SK-MEL-2	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUCxTGdDUUN3ME20Nk43PDB3IN88US=>	NHvnOoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
LC-1F	NUHSelhOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mor0TWM2OD12Mz6zOlgzKM7:TR?=	Mn:0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM2Nyd-U1HOS2VTRC:jPh?=
NH-12	NVPuPZFKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXPJZpRXUUN3ME20N{46OzV7IN88US=>	NGrod5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzVxJ{7TRW5ITVJ:L3G+
RKO	NVz5TJdnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NViwOZE4UUN3ME20OE4yOjV{IN88US=>	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1N\|UwLz6VQV7HSXI9N2F-
KM-H2	NVuxdXV5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml\GTWM2OD12ND65OVc4KM7:TR?=	NVHwOHV5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>
SK-UT-1	NV[3eHdJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGjhRpBKSzVyPUS5Mlg5OjVizszN	NVrrV3E5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN3Lze+V2FPT0WUPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-STAT3 / STAT3 / p-Src / Src / p-AKT / AKT / p-ERK / ERK ; PubMed: 19244102 Cancer Res Sunitinib reduced Stat3 and Src activity, with no dramatic reduction of AKT, MAPK and JAK signaling in 786-O cells. Tumor cells were treated with sunitinib at indicated concentrations for 2 h (left panels) or 24 h (right panels). Total cell lysates were prepared and western blots were performed using relevant antibodies to detect total protein levels, with β-actin used as the loading control. p-GSK3β / GSK3β / MYCN ; PubMed: 24759734 PLoS One Effect of sunitinib on GSK3β phosphorylation and on MYCN total protein in MYCN amplified NB cell lines. p-AKT / AKT / p-ERK / ERK; PubMed: 24759734 PLoS One Effect of 72 h treatment with sunitinib on SH-SY5Y, SK N BE(2), SK-N-AS and IMR-32 NB cell lines analyzed by Western blot with pSer473Akt, Akt, pThr202/Thr204 Erk1/2 and Erk1/2 antibodies. β-actin was used as a loading control.	19244102 24759734
Growth inhibition assay	Cell viability; PubMed: 24369536 Biomed Res Int Isolated effects of sunitinib malate on urinary bladder-cancer cell lines viability, assessed by using the MTT assay. The data shown and bars represent the mean values ± SD (SD: standard deviation). *P < 0.05 versus untreated cells.	24369536

In vivo

Consistent with the substantial and selective inhibition of VEGFR2 or PDGFR phosphorylation and signaling in vivo, Sunitinib (20-80 mg/kg/day) exhibits broad and potent dose-dependent anti-tumor activity against a variety of tumor xenograft models including HT-29, A431, Colo205, H-460, SF763T, C6, A375, or MDA-MB-435. Sunitinib dosing at 80 mg/kg/day for 21 days leads to complete tumor regression in six of eight mice, without tumor re-growing during a 110-day observation period after the end of treatment. Second round of treatment with Sunitinib remains efficacious against tumors that are not fully regressed during the first round of treatment. Sunitinib treatment results in significant decrease in tumor MVD, with ~40% reduction in SF763T glioma tumors. SU11248 treatment results in a complete inhibition of additional tumor growth of luciferase-expressing PC-3M xenografts, despite no reduction in tumor size. ^[2] Sunitinib treatment (20 mg/kg/day) dramatically suppresses the growth subcutaneous MV4;11 (FLT3-ITD) xenografts and prolongs survival in the FLT3-ITD bone marrow engraftment model. ^[3]

Protocol

Kinase Assay: ^[1]	- Collapse Biochemical Tyrosine Kinase Assays: IC50 values for Sunitinib against VEGFR2 (Flk-1) and PDGFRβ are determined using glutathione S-transferasefusion proteins containing the complete cytoplasmic domain of the RTK. Biochemical tyrosine kinase assays to quantitate the trans-phosphorylation activity of VEGFR2 (Flk-1) and PDGFRβ are performed in 96-well microtiter plates precoated (20 μg/well in PBS; incubated overnight at 4 °C) with the peptide substrate poly-Glu,Tyr (4:1). Excess protein binding sites are blocked with the addition of 1-5% (w/v) BSA in PBS. Purified GST-fusion proteins are produced in baculovirus-infected insect cells. GST-VEGFR2 and GST-PDGFRβ are then added to the microtiter wells in 2 × concentration kinase dilution buffer consisting of 100 mM HEPES, 50 mM NaCl, 40 μM NaVO₄, and 0.02% (w/v) BSA. The final enzyme concentration for GST-VEGFR2 or GST-PDGFRβ is 50 ng/mL. Twenty-five μL of diluted Sunitinib are subsequently added to each reaction well to produce a range of inhibitor concentrations appropriate for each enzyme. The kinase reaction is initiated by the addition of different concentrations of ATP in a solution of MnCl₂ so that the final ATP concentrations spanned the Km for the enzyme, and the final concentration of MnCl₂ is 10 mM. The plates are incubated for 5-15 minutes at room temperature before stopping the reaction with the addition of EDTA. The plates are then washed three times with TBST. Rabbit polyclonal antiphosphotyrosine antisera are added to the wells at a 1:10,000 dilution in TBST containing 0.5% (w/v) BSA, 0.025% (w/v) nonfat dry milk, and 100 μM NaVO₄ and incubated for 1 hour at 37 °C. The plates are then washed three times with TBST, followed by the addition of goat antirabbit antisera conjugated with horseradish peroxidase (1:10,000 dilution in TBST). The plates are incubated for 1 hour at 37 °C and then washed three times with TBST. The amount of phosphotyrosine in each well is quantitated after the addition of 2,2′-azino-di-[3-ethylbenzthiazoline sulfonate] as substrate.
Cell Research: ^[3]	- Collapse Cell lines: RS4;11, MV4;11, and OC1-AML5 Concentrations: Dissolved in DMSO, final concentrations ~10 μM Incubation Time: 24 and 48 hours Method: Cells are starved overnight in medium containing 0.1% FBS prior to addition of Sunitinib and FL (50 ng/mL; FLT3-WT cells only). Proliferation is measured after 48 hours of culture using the Alamar Blue assay or trypan blue cell viability assays. Apoptosis is measured 24 hours after Sunitinib addition by Western blotting to detect cleavage of poly (ADP-ribose) polymerase (PARP) or levels of caspase-3. (Only for Reference)
Animal Research: ^[2]	- Collapse Animal Models: Female nu/nu mice implanted s.c. with HT-29, A431, Colo205, H-460, SF763T, C6, A375, or MDA-MB-435, and male nu/nu mice bearing luciferase-expressing PC-3M tumors Dosages: ~80 mg/kg Administration: Orally once daily (Only for Reference)

References

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Solubility (25°C)

In vitro	DMSO	15 mg/mL (28.16 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 4% DMSO+30% PEG 300+ddH2O For best results, use promptly after mixing.	2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Sunitinib (SU11248) malate SDF

Molecular Weight	532.56
Formula	C₂₂H₂₇FN₄O₂.C₄H₆O₅
CAS No.	341031-54-7
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO+ % + % Tween 80+ % ddH₂O

Calculate Reset

Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04669366	Recruiting	Drug: sunitinib\|Drug: axitinib	Kidney Neoplasms	Pfizer	January 20 2021	--
NCT04633122	Recruiting	Drug: Ripretinib\|Drug: Sunitinib	Gastrointestinal Stromal Tumor(GIST)	Zai Lab (Shanghai) Co. Ltd.	November 25 2020	Phase 2
NCT04115189	Completed	Drug: Sunitinib	Metastatic Renal Cell Carcinoma ( mRCC)	Pfizer	December 13 2019	--
NCT04175262	Completed	Drug: sunitinib	Metastatic Renal Cell Carcinoma (mRCC)	Pfizer\|IMDC group\|Analysis Group	October 31 2019	--
NCT04033991	Completed	Drug: Sunitinib\|Drug: Axitinib	Carcinoma\|Renal Cell	Pfizer	September 27 2019	--

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
I was wondering that the compound is in its cis or trans form?
Answer:
S1042 Sunitinib Malate is Z form.
Question 2:
What is the difference between Sunitinib Malate(S1042) and Sunitinib(S7781)?
Answer:
S1042 is the Malate salt form of Sunitinib. The biological activities of these two compounds are the same but the solubility of these two compounds in aqueous solvent are different.

PDGFR Signaling Pathway Map

PDGFR Inhibitors with Unique Features

Selective VEGFR Inhibitors

Vandetanib (ZD6474) : VEGFR2-selective, IC50=40 nM.
Most Potent VEGFR Inhibitor

Cabozantinib (XL184, BMS-907351) : VEGFR2, IC50=0.035 nM.
FDA-approved VEGFR Inhibitor

Axitinib : Approved by FDA for Renal Cell Carcinoma.
Classic VEGFR Inhibitor

Nintedanib (BIBF 1120) : Potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. Phase 3.

Related PDGFR Products

Sunitinib (SU11248) ^New

Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.
Erlotinib (OSI-774) ^New

Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.
Bemcentinib (R428) ^New

Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).
CP-673451

CP-673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM in cell-free assays, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity.
Imatinib (STI571)

Imatinib (STI571, CGP057148B, Gleevec) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib (STI571) induces autophagy.
Crenolanib (CP-868596)

Crenolanib (CP-868596, ARO 002) is a potent and selective inhibitor of PDGFRα/β with K_d of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.
Tyrphostin AG 1296

Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. Tyrphostin AG1296 inhibits FGFR and c-Kit with IC50 of 12.3 μM and 1.8 μM in Swiss 3T3 cells. Tyrphostin AG1296 induces dramatic apoptosis in A375R cells.
Sennoside B

Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
Gefitinib (ZD1839)

Gefitinib (ZD-1839, Iressa) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway.

Features:A potent EGFR tyrosine kinase inhibitor.

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Sunitinib (SU11248) malate