Silver Sulfadiazine

Catalog No.S4822

For research use only.

Silver sulfadiazine is a bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast.

Silver Sulfadiazine Chemical Structure

CAS No. 22199-08-2

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Silver sulfadiazine is a bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast.
In vitro

The inhibitory effect of Ag-SD on keratinocyte and fibroblast growth induced the retardation of wound closure rate[1].

In vivo Silver sulfadiazine is considered the gold standard for burn treatment[1].

Protocol (from reference)

Cell Research:


  • Cell lines: HaCaT cells
  • Concentrations: 0.5%-1%
  • Incubation Time: 1 week
  • Method:

    Human HaCaT keratinocytes were incubated in 2-ml Dulbecco's Modified Eagle's Medium (DMEM) supplemented with 10% fetal bovine serum. The cultures were maintained up to 80% confluence in 35-mm petridish before treating with Ag-SD and EGF. Samples of collagen sponge disk (0.2 cm2) were prepared by soaking in different concentrations of Ag-SD and/or EGF solutions and freeze-dried. Before usage, the sponges were sterilized by g-irradiation. The sterile sponges of 30-mm diameter were placed in 6-well tissue culture plate, seeded with 0.8×105 HaCaT cells per sponge and cultured in 5% CO2 and 95% humidity for 1 week. Cell viability was assessed by the MTT method.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 357.14


CAS No. 22199-08-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+]

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00413738 Completed Device: Antiseptic-coated central venous catheters Infection Centre National de Greffe de Moelle Osseuse December 2006 Phase 3

(data from, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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