Silver Sulfadiazine

For research use only.

Catalog No.S4822

Silver Sulfadiazine Chemical Structure

CAS No. 22199-08-2

Silver sulfadiazine is a bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast.

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Silver sulfadiazine is a bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast.
In vitro

The inhibitory effect of Ag-SD on keratinocyte and fibroblast growth induced the retardation of wound closure rate[1].

In vivo Silver sulfadiazine is considered the gold standard for burn treatment[1].

Protocol

Cell Research:

[1]

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  • Cell lines: HaCaT cells
  • Concentrations: 0.5%-1%
  • Incubation Time: 1 week
  • Method:

    Human HaCaT keratinocytes were incubated in 2-ml Dulbecco's Modified Eagle's Medium (DMEM) supplemented with 10% fetal bovine serum. The cultures were maintained up to 80% confluence in 35-mm petridish before treating with Ag-SD and EGF. Samples of collagen sponge disk (0.2 cm2) were prepared by soaking in different concentrations of Ag-SD and/or EGF solutions and freeze-dried. Before usage, the sponges were sterilized by g-irradiation. The sterile sponges of 30-mm diameter were placed in 6-well tissue culture plate, seeded with 0.8×105 HaCaT cells per sponge and cultured in 5% CO2 and 95% humidity for 1 week. Cell viability was assessed by the MTT method.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 0.1 mg/mL (0.28 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 357.14
Formula

C10H9AgN4O2S

CAS No. 22199-08-2
Storage powder
in solvent
Synonyms N/A
Smiles C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+]

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00413738 Completed Device: Antiseptic-coated central venous catheters Infection Centre National de Greffe de Moelle Osseuse December 2006 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID