Sertraline HCl

Catalog No.S4053 Synonyms: CP-51974-1 HCl

Sertraline HCl Chemical Structure

Molecular Weight(MW): 342.69

Sertraline HCl is a 5-HT antagonist with Ki of 13 nM.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 270 In stock
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Biological Activity

Description Sertraline HCl is a 5-HT antagonist with Ki of 13 nM.
5-HT [1]
13 nM(Ki)
In vitro

Sertraline exhibits better selectivity for inhibiting 5-HT uptake relative to NE uptake than fluvoxamine, zimelidine, norzimelidine, fluoxetine or chlorimipramine. However, Sertraline is less selective for blocking 5-HT uptake, relative to DA uptake than these agents. [1]

In vivo Sertraline HCl (32μmol/kg i.p.) inhibits serotonin uptake into striatal synaptosomes from rats by more than 50%. Sertraline HCl is 6 times more potent than chlorimipramine and 60 times more potent than amitriptyline in reversing the 5-HT depletion elicited by PCA. Acute and repeated dosing of sertraline decreased serotonin content of whole blood. Sertraline HCl strongly reduces immobility of mice in the Porsolt swim test for antidepressants. After repeated dosing in rats, sertraline HCl diminishes the cyclic AMP response of limbic forebrain adenylate cyclase to norepinephnne, as well as the binding of [3H]dihydroalprenolol to cortical membranes. [1]


Animal Research:


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  • Animal Models: Rats, Mice
  • Formulation: In water or the mixture (% by volume), 5% ethanol + 5% Emulphor-EL-620 + 90%normal saline.
  • Dosages: --
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 69 mg/mL (201.34 mM)
Ethanol 15 mg/mL (43.77 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 342.69


CAS No. 79559-97-0
Storage powder
in solvent
Synonyms CP-51974-1 HCl

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03852160 Not yet recruiting Depressive Disorder Treatment-Resistant Janssen-Cilag International NV May 15 2019 Phase 3
NCT03841474 Recruiting Coronary Artery Disease|Depression|Cardiovascular Diseases Klinički Bolnički Centar Zagreb March 1 2019 Not Applicable
NCT03779789 Not yet recruiting Major Depressive Disorder Azienda Ospedaliera Universitaria Integrata Verona|University of Catania February 1 2019 Phase 4
NCT03511118 Recruiting Lactating Women on Select DOI|Breastfed Infants of Mothers on Select DOI Kevin Watt|The EMMES Corporation|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Duke University October 4 2018 --
NCT03538691 Recruiting Major Depressive Disorder Otsuka Pharmaceutical Development & Commercialization Inc. July 13 2018 Phase 3
NCT03434041 Recruiting Depressive Disorder Treatment-Resistant Janssen Research & Development LLC May 25 2018 Phase 3

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID