Sertraline HCl

Catalog No.S4053 Synonyms: CP-51974-1 HCl

Sertraline HCl Chemical Structure

Molecular Weight(MW): 342.69

Sertraline HCl is a 5-HT antagonist with Ki of 13 nM.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 270 In stock
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Biological Activity

Description Sertraline HCl is a 5-HT antagonist with Ki of 13 nM.
Targets
5-HT [1]
13 nM(Ki)
In vitro

Sertraline exhibits better selectivity for inhibiting 5-HT uptake relative to NE uptake than fluvoxamine, zimelidine, norzimelidine, fluoxetine or chlorimipramine. However, Sertraline is less selective for blocking 5-HT uptake, relative to DA uptake than these agents. [1]

In vivo Sertraline HCl (32μmol/kg i.p.) inhibits serotonin uptake into striatal synaptosomes from rats by more than 50%. Sertraline HCl is 6 times more potent than chlorimipramine and 60 times more potent than amitriptyline in reversing the 5-HT depletion elicited by PCA. Acute and repeated dosing of sertraline decreased serotonin content of whole blood. Sertraline HCl strongly reduces immobility of mice in the Porsolt swim test for antidepressants. After repeated dosing in rats, sertraline HCl diminishes the cyclic AMP response of limbic forebrain adenylate cyclase to norepinephnne, as well as the binding of [3H]dihydroalprenolol to cortical membranes. [1]

Protocol

Animal Research:

[1]

+ Expand
  • Animal Models: Rats, Mice
  • Formulation: In water or the mixture (% by volume), 5% ethanol + 5% Emulphor-EL-620 + 90%normal saline.
  • Dosages: --
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 69 mg/mL (201.34 mM)
Ethanol 15 mg/mL (43.77 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 342.69
Formula

C17H17Cl2N.HCl

CAS No. 79559-97-0
Storage powder
in solvent
Synonyms CP-51974-1 HCl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03711708 Completed Drug: Zoloft Oral Solution|Drug: Zoloft tablets Healthy Pfizer November 6 2018 Phase 4
NCT02641652 Unknown status Drug: Sertraline|Drug: Placebo Hypertension University Hospital Olomouc|Brno University Hospital|St. Anne|University Hospital Ostrava|Tomas Bata Hospital Czech Republic|Prerov Hospital|Valasske Mezirici Hospital|Thomayerova Teaching Hospital|Vsetin Hospital November 2017 Phase 4
NCT03342963 Completed Drug: ASC-01|Drug: Aripiprazole and sertraline Healthy Male Adults Otsuka Pharmaceutical Co. Ltd. November 21 2017 Phase 1
NCT03978286 Completed Drug: Vortioxetine|Drug: Sertraline Depression|Type 2 Diabetes Mellitus Universidad Juárez Autónoma de Tabasco June 30 2016 Phase 4
NCT02651623 Completed Drug: Sertraline|Drug: Moxifloxacin|Drug: Drug - Placebo Healthy Pfizer January 2016 Phase 1

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID