Sertraline HCl

Catalog No.S4053 Synonyms: CP-51974-1 HCl

For research use only.

Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM.

Sertraline HCl Chemical Structure

CAS No. 79559-97-0

Selleck's Sertraline HCl has been cited by 3 Publications

Purity & Quality Control

Choose Selective Serotonin Transporter Inhibitors

Biological Activity

Description Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM.
Targets
5-HT [1]
13 nM(Ki)
In vitro

Sertraline exhibits better selectivity for inhibiting 5-HT uptake relative to NE uptake than fluvoxamine, zimelidine, norzimelidine, fluoxetine or chlorimipramine. However, Sertraline is less selective for blocking 5-HT uptake, relative to DA uptake than these agents. [1]

In vivo Sertraline HCl (32μmol/kg i.p.) inhibits serotonin uptake into striatal synaptosomes from rats by more than 50%. Sertraline HCl is 6 times more potent than chlorimipramine and 60 times more potent than amitriptyline in reversing the 5-HT depletion elicited by PCA. Acute and repeated dosing of sertraline decreased serotonin content of whole blood. Sertraline HCl strongly reduces immobility of mice in the Porsolt swim test for antidepressants. After repeated dosing in rats, sertraline HCl diminishes the cyclic AMP response of limbic forebrain adenylate cyclase to norepinephnne, as well as the binding of [3H]dihydroalprenolol to cortical membranes. [1]

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: Rats, Mice
  • Dosages: --
  • Administration: i.p.

Solubility (25°C)

In vitro

DMSO 69 mg/mL
(201.34 mM)
Water Insoluble
Ethanol '15 mg/mL

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.

5 mg/mL

Chemical Information

Molecular Weight 342.69
Formula

C17H17Cl2N.HCl

CAS No. 79559-97-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05189977 Recruiting Drug: Propranolol / Prazosin Post-traumatic Stress Disorder (PTSD) Otsuka Pharmaceutical Development & Commercialization Inc.|Iqvia Pty Ltd January 24 2022 Phase 1
NCT04147000 Recruiting -- Overweight|Depression|Anxiety Disorders Linkoeping University|Örebro University Sweden January 1 2020 --
NCT03711708 Completed Drug: Zoloft Oral Solution|Drug: Zoloft tablets Healthy Pfizer''s Upjohn has merged with Mylan to form Viatris Inc.|Pfizer November 6 2018 Phase 4
NCT02641652 Unknown status Drug: Sertraline|Drug: Placebo Hypertension University Hospital Olomouc|Brno University Hospital|St. Anne|University Hospital Ostrava|Tomas Bata Hospital Czech Republic|Prerov Hospital|Valasske Mezirici Hospital|Thomayer University Hospital|Vsetin Hospital November 2017 Phase 4
NCT03342963 Completed Drug: ASC-01|Drug: Aripiprazole and sertraline Healthy Male Adults Otsuka Pharmaceutical Co. Ltd. November 21 2017 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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