Catalog No.S4053 Synonyms: CP-51974-1 HCl
Molecular Weight(MW): 342.69
Sertraline HCl is a 5-HT antagonist with Ki of 13 nM.
Purity & Quality Control
Choose Selective 5-HT Receptor Inhibitors
|Description||Sertraline HCl is a 5-HT antagonist with Ki of 13 nM.|
Sertraline exhibits better selectivity for inhibiting 5-HT uptake relative to NE uptake than fluvoxamine, zimelidine, norzimelidine, fluoxetine or chlorimipramine. However, Sertraline is less selective for blocking 5-HT uptake, relative to DA uptake than these agents. 
|In vivo||Sertraline HCl (32μmol/kg i.p.) inhibits serotonin uptake into striatal synaptosomes from rats by more than 50%. Sertraline HCl is 6 times more potent than chlorimipramine and 60 times more potent than amitriptyline in reversing the 5-HT depletion elicited by PCA. Acute and repeated dosing of sertraline decreased serotonin content of whole blood. Sertraline HCl strongly reduces immobility of mice in the Porsolt swim test for antidepressants. After repeated dosing in rats, sertraline HCl diminishes the cyclic AMP response of limbic forebrain adenylate cyclase to norepinephnne, as well as the binding of [3H]dihydroalprenolol to cortical membranes. |
|In vitro||DMSO||69 mg/mL (201.34 mM)|
|Ethanol||15 mg/mL (43.77 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03711708||Completed||Drug: Zoloft Oral Solution|Drug: Zoloft tablets||Healthy||Pfizer||November 6 2018||Phase 4|
|NCT02641652||Unknown status||Drug: Sertraline|Drug: Placebo||Hypertension||University Hospital Olomouc|Brno University Hospital|St. Anne|University Hospital Ostrava|Tomas Bata Hospital Czech Republic|Prerov Hospital|Valasske Mezirici Hospital|Thomayerova Teaching Hospital|Vsetin Hospital||November 2017||Phase 4|
|NCT03342963||Completed||Drug: ASC-01|Drug: Aripiprazole and sertraline||Healthy Male Adults||Otsuka Pharmaceutical Co. Ltd.||November 21 2017||Phase 1|
|NCT03978286||Completed||Drug: Vortioxetine|Drug: Sertraline||Depression|Type 2 Diabetes Mellitus||Universidad Juárez Autónoma de Tabasco||June 30 2016||Phase 4|
|NCT02651623||Completed||Drug: Sertraline|Drug: Moxifloxacin|Drug: Drug - Placebo||Healthy||Pfizer||January 2016||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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