For research use only. Not for use in humans.

Siltuximab (anti-IL-6)

Synonyms: CNTO 328 Cat.No.A2030 Purity:99.93%

Siltuximab (anti-IL-6) (CNTO 328) is a human-mouse chimeric monoclonal antibody that binds human interleukin-6 (IL-6).

Click to purchase the isotype control of Siltuximab (anti-IL-6)

1 Citation

17 Nobel Prize winners have used Selleck products

Shimon Sakaguchi

Nature Communications 2025,16, Article number:1325

David Baker

Dev Cell 2023, 58(20):2163-2180.e9.

David Julius

Cell 2017, 185-198.e16

Michael Houghton

Cell Chem Biol, 2020, 27(7):780-792.e5

Charles M. Rice

Cell 2018, 172(3):423-438.e25

Quality Control

Batch: Purity: 99.93% Protein concentration: 5.6mg/ml Endotoxin Level: ＜1EU/mg

99.93

Specificity

Name	Citation	IL-6	IL-1	IL-8	IL-12	IL-10	IL-13	IL-2	Others
SKF-86002	0		++
JTE-607 Dihydrochloride	0	+++	+++	+++		+++			TNF-alpha
A-740003	2		++						rat P2X7 receptor,human P2X7 receptor
Apilimod mesylate	3				++++				PIKfyve
MD2-TLR4-IN-1	0	++							TLR4,TNF-α
Danirixin (GSK1325756)	2			++					CXCR2
Resatorvid (TAK-242)	62	++++							TLR4,NO,TNF-α
Apilimod	17				++++				PIKfyve
LMT-28	0	✔
Atractylodin	0	✔							NAAA
Triolein	0	✔							ROS,MMP-1
Ac-YVAD-cmk	4		✔
Diethyl phosphate	0	✔
RCM-1	5						✔		STAT6,FOXM1,β-catenin
Stylopine	0		✔						COX-2,TNF-α,NO
Myrislignan	1	✔							NF-κB,COX-2,iNOS
NE 52-QQ57	1		✔						iNOS,TNF-α,PGE2
PKR-IN-C16	7		✔						PKR
(3R,8S)-Falcarindiol	3	✔							STAT,ERK,JNK
Gardenoside	0		✔						P2X7 Receptor,P2X3 receptor,NF-κB
T-5224	22		✔						c-Jun,c-Fos/AP-1,Adamts-5
IQ 3	1	✔							TNF-α,JNK3,JNK1
Isuzinaxib (APX-115 free base)	0	✔							TNFα,MCP-1/CCL2,NOX2
AUDA	0		✔						p38,Smad3,TGF-β
SAR-20347	1				✔				IFN-α,TYK2,JAK1
SU 5201	0							✔
Madecassic acid	1		✔						TNF-α,COX-2,iNOS
Homoplantaginin	1	✔							NF-κB,IKKβ,TNF-α
2',5'-Dihydroxyacetophenone	1	✔							NF-κB,ERK1/2,iNOS
Forsythoside B	0	✔							NF-κB,TNF-alpha,IκB
Mulberroside A	0		✔						NF-κB,Caspase-1,NALP3
Chelidonic acid	0	✔							glutamate decarboxylase,Caspase-1,NF-κB
4-Methylesculetin	0	✔							MPO
Muscone	4		✔						TNF-α,NLRP3 inflammasome,NF-κB
Ossirene (AS101)	13		✔
Methylthiouracil	0	✔							ERK1/2,NF-κB,TNF-α

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Siltuximab (anti-IL-6) (CNTO 328) is a human-mouse chimeric monoclonal antibody that binds human interleukin-6 (IL-6).
References	[1] https://pubmed.ncbi.nlm.nih.gov/21321981/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	541502-14-1
Molecular Weight	145 kDa
Isotype	Human IgG1, κ
Source	CHO cells
Sterility	0.2 μM filtered
Formulation	PBS Buffer, PH 7.4
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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