Sorafenib (BAY 43-9006)

For research use only.

Catalog No.S7397 Synonyms: NSC-724772

355 publications

Sorafenib (BAY 43-9006) Chemical Structure

CAS No. 284461-73-0

Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.

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Selleck's Sorafenib (BAY 43-9006) has been cited by 355 publications

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
Targets
Raf-1 [1]
(Cell-free assay)
mVEGFR2(Flk1) [1]
(Cell-free assay)
mVEGFR3 [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
B-Raf (V599E) [1]
(Cell-free assay)
6 nM 15 nM 20 nM 22 nM 38 nM
In vitro

Sorafenib inhibits both wild-type and V599E mutant B-Raf activity with IC50 of 22 nM and 38 nM, respectively. Sorafenib also potently inhibits mVEGFR2 (Flk-1), mVEGFR3, mPDGFRβ, Flt3, and c-Kit with IC50 of 15 nM, 20 nM, 57 nM, 58 nM, and 68 nM, respectively. Sorafenib weakly inhibits FGFR-1 with IC50 of 580 nM. Sorafenib tosylate is not active against ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-Met, PKB, PKA, cdk1/cyclinB, PKCα, PKCγ, and pim-1. Sorafenib markedly inhibits VEGFR2 phosphorylation in NIH 3T3 cells with IC50 of 30 nM, and Flt-3 phosphorylation in HEK-293 cells with IC50 of 20 nM. Sorafenib potently blocks MEK 1/2 and ERK 1/2 phosphorylation in most cell lines but not in A549 or H460 cells, while having no effect on inhibition of the PKB pathway. Sorafenib inhibits the proliferation of HAoSMC and MDA-MB-231 cells with IC50 of 0.28 μM and 2.6 μM, respectively. [1] In addition to inhibition of the RAF/MEK/ERK signaling pathway, Sorafenib significantly inhibits the phosphorylation of eIF4E and down-regulates Mcl-1 levels in hepatocellular carcinoma (HCC) cells in a MEK/ERK-independent manner. Sorafenib inhibits the proliferation of PLC/PRF/5 and HepG2 cells with IC50 of 6.3 μM and 4.5 μM, respectively, and leads to the significant induction of apoptosis. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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F-6-8 NU\XWVR[S3m2b4TvfIlkcXS7IHHzd4F6 NVXh[mhGUUN3MDC9JFEvOyEQvF2= NEP5U4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOxPFk6QCd-Mk[zNVg6QTh:L3G+
A549 MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M4i5RWlEPTBiPTCxMlQ2KM7:TR?= NVXOS3h1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zOFIyOzRpPkK2N|QzOTN2PD;hQi=>
rhabdomyosarcoma M3nHdWFvfGm4aYLhcEBi[3Srdnn0fUBie3OjeR?= NX\KclZETUN3MDC9JFEvPSEQvF2= NUL5Z5Q3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyPFgyQDZpPkK3Nlg5OTh4PD;hQi=>
HL-60(TB) Mke4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUDHTVUxKD1iMT61PEDPxE1? NHrXRYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
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HCT116 NWjlXnpST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1HUUGdKPTBiPTCxMlU5KM7:TR?= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
HOP92 MlG4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlzvS2k2OCB;IEGuOVgh|ryP M{DL[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
SF539 M1\lUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnmzS2k2OCB;IEGuOVgh|ryP MnzFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
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T47D NV3Jb3RMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHzkUIdIUTVyIE2gNU42QCEQvF2= NI[0RlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
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HL-60(TB) NHLONGlEgXSxdH;4bYNqfHliYYPzZZk> MYnHTVUxKD1iMT61PEDPxE1? NITVWGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
KM12 M4LNOGN6fG:2b4jpZ4l1gSCjc4PhfS=> NGLnNphIUTVyIE2gNU42QCEQvF2= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
HCT116 NV34T|k4S3m2b4TvfIlkcXS7IHHzd4F6 NHfiTYtIUTVyIE2gNU42QCEQvF2= Mof4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
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SF539 M1\UW2N6fG:2b4jpZ4l1gSCjc4PhfS=> MWDHTVUxKD1iMT61PEDPxE1? NHHpNpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
SK-MEL-2 MV\DfZRwfG:6aXPpeJkh[XO|YYm= NInzTItIUTVyIE2gNU42QCEQvF2= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
MDA-MB-435 MYLDfZRwfG:6aXPpeJkh[XO|YYm= NHS3bIlIUTVyIE2gNU42QCEQvF2= MmrsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
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LOXIMVI M3PjemN6fG:2b4jpZ4l1gSCjc4PhfS=> M3\ybWdKPTBiPTCxMlU5KM7:TR?= NV7aOW5MRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
T47D NYL0TGk5S3m2b4TvfIlkcXS7IHHzd4F6 M33jb2dKPTBiPTCxMlU5KM7:TR?= M4nTdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
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MDA-MB-435 M1HWXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M3e3OGdKPTBiPTCxMlU5KM7:TR?= NVrn[5YzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SF539 MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MY\HTVUxKD1iMT61PEDPxE1? NH;1eFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SF295 Mo\4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MXXHTVUxKD1iMT61PEDPxE1? NVzySJo2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
HCT116 M3HtcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MUHHTVUxKD1iMT61PEDPxE1? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
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RPMI8226 NV;GN414SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Mn7IS2k2OCB;IEGuOVgh|ryP NUTpeFNKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
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A549 M1LvbGN6fG:2b4jpZ4l1gSCjc4PhfS=> NWfub3pjUUN3MDC9JFEvQTJizszN NYq4R45ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NlY5OTVpPkK0PFI3QDF3PD;hQi=>
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U937 M4jldWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NVXCU|h{T0l3MDC9JFIvPzRizszN NV;aRYZTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zNVgxPjdpPkK2N|E5ODZ5PD;hQi=>
U937 NYTRU5lQS3m2b4TvfIlkcXS7IHHzd4F6 M{fmc2dKPTBiPTCyMlc1KM7:TR?= NGfCT4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi3PFE6Oyd-MkS4O|gyQTN:L3G+
MCF7 MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlvYTWM2OCB;IEKuO|gh|ryP NWf0cphyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxNFIyPzVpPkK5NVAzOTd3PD;hQi=>
MDA-MB-231 MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MoXVTWM2OCB;IEKuPEDPxE1? MnqzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{MEK0NFMoRjJ7MkCyOFA{RC:jPh?=
HepG2 MoPtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NVXVeYtuUUN3MDC9JFIvQDRizszN NWfVZ5htRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyOFI2PTNpPkK4NlQzPTV|PD;hQi=>
U937 NXK3TYNXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXrHTVUxKD1iMj64OUDPxE1? MnnCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMUS3OVUoRjJ{MEG0O|U2RC:jPh?=
A549 NH3x[nNEgXSxdH;4bYNqfHliYYPzZZk> MlLVTWM2OCB;IEKuPVIh|ryP NGrzXpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyO|gxOSd-Mki5Nlc5ODF:L3G+
A549 NF3FOnJEgXSxdH;4bYNqfHliYYPzZZk> NFXuUodKSzVyIE2gNk46OiEQvF2= MojkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5N{ewNFkoRjJ5N{e3NFA6RC:jPh?=
ZR75-30 NEX4RZBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFy1bo9KSzVyIE2gNk46PiEQvF2= M2DpSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUCyNVc2Lz5{OUGwNlE4PTxxYU6=
PC3 NYXGUlgxS3m2b4TvfIlkcXS7IHHzd4F6 NVHHTGhxUUN3MDC9JFMvODNizszN Mn\3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|NEC5NVMoRjJ6M{SwPVE{RC:jPh?=
MDA-MB-231 NFjWcJBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MUPJR|UxKD1iMz6wPEDPxE1? MmTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7OUG5N|goRjJ4OUmxPVM5RC:jPh?=
A549 MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGHJNIdKSzVyIE2gN{4yKM7:TR?= Mny0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzMEKxO|UoRjJ7MUCyNVc2RC:jPh?=
K562 NX2wUnRFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVqxVW41T0l3MDC9JFMvOTZizszN NVPsfnpvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
MOLT4 NFTmWXNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnH3S2k2OCB;IEOuNVYh|ryP NUXZNZJZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
A549/ATCC NHzaSI9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYnHTVUxKD1iMz6xOkDPxE1? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
RPMI8226 MnuwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmHuWGdKKD1iMz6xOkDPxE1? MnTnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
SR MnXJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn;sS2k2OCB;IEOuNVYh|ryP Mki0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
HOP62 NGTvOlJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHXMe21VT0liPTCzMlE3KM7:TR?= M1HFSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
NCI-H226 M{LHdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoDQWGdKKD1iMz6xOkDPxE1? M2nLXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
U251 MlL2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnzQWGdKKD1iMz6xOkDPxE1? M4HmcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
COLO205 NYfoR2U6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1HwVHRIUSB;IEOuNVYh|ryP MoruQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
M14 NVjqUGloT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVnUS2khRSB|LkG2JO69VQ>? NEPSPWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
HCC2998 M3W2cGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYXHTVUxKD1iMz6xOkDPxE1? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
SNB75 MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnLuS2k2OCB;IEOuNVYh|ryP MkDQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
786-0 MoXMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYnHTVUxKD1iMz6xOkDPxE1? NYjFOWpmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
A498 MmrPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmjWWGdKKD1iMz6xOkDPxE1? NGHCd4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
HCT15 NGT0dZNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1HXOHRIUSB;IEOuNVYh|ryP MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
OVCAR3 MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWLHTVUxKD1iMz6xOkDPxE1? MknjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
OVCAR4 NV\GR|hXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWHHTVUxKD1iMz6xOkDPxE1? NVHLO|Z2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
Caki1 MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2mzZ2dKPTBiPTCzMlE3KM7:TR?= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
SNB19 NGLXdWdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX3HTVUxKD1iMz6xOkDPxE1? M2rDNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
OVCAR5 MnHmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV\HTVUxKD1iMz6xOkDPxE1? MnHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
DU145 Mn7ZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHrpOFlIUTVyIE2gN{4yPiEQvF2= M1fVelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
OVCAR8 MoW0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHHofGNIUTVyIE2gN{4yPiEQvF2= NVjJT2NFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
SN12C MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MonZWGdKKD1iMz6xOkDPxE1? NV[wc2VnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
MDA-MB-231 NFjpeIJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYnqW5JSXEeLIE2gN{4yPiEQvF2= MkHyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
RXF393 M2TqRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXfR[WlGT0l3MDC9JFMvOTZizszN NVLjSVNJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
BT549 NIK1PGVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1X5OmdKPTBiPTCzMlE3KM7:TR?= M2fVcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
K562 NYHqO204S3m2b4TvfIlkcXS7IHHzd4F6 Ml;0S2k2OCB;IEOuNVYh|ryP NYfZepFtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
MOLT4 M2\JbWN6fG:2b4jpZ4l1gSCjc4PhfS=> M1vQdmdKPTBiPTCzMlE3KM7:TR?= MkiyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
SNB19 M2rlR2N6fG:2b4jpZ4l1gSCjc4PhfS=> MWfHTVUxKD1iMz6xOkDPxE1? M4THXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
SR MWPDfZRwfG:6aXPpeJkh[XO|YYm= M2T4UWdKPTBiPTCzMlE3KM7:TR?= M{nGW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
A549 MlTTR5l1d3SxeHnjbZR6KGG|c3H5 MVvHTVUxKD1iMz6xOkDPxE1? M{TXdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
OVCAR3 M3\PcGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2\1[GdKPTBiPTCzMlE3KM7:TR?= MoW4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
OVCAR4 MmXyR5l1d3SxeHnjbZR6KGG|c3H5 NX2wUXF6T0l3MDC9JFMvOTZizszN MnHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
SNB75 M4jiXGN6fG:2b4jpZ4l1gSCjc4PhfS=> MX;HTVUxKD1iMz6xOkDPxE1? M4G3XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
OVCAR5 MXHDfZRwfG:6aXPpeJkh[XO|YYm= NE\QeGlIUTVyIE2gN{4yPiEQvF2= NFzCNXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
DU145 NHG4NlVEgXSxdH;4bYNqfHliYYPzZZk> NEDBZWZIUTVyIE2gN{4yPiEQvF2= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
786-0 M13qXmN6fG:2b4jpZ4l1gSCjc4PhfS=> M4DjU2dKPTBiPTCzMlE3KM7:TR?= M{LZT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
BT549 Mo\sR5l1d3SxeHnjbZR6KGG|c3H5 NYTGbYdmT0l3MDC9JFMvOTZizszN NG[wfJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
ACHN MlPMR5l1d3SxeHnjbZR6KGG|c3H5 NI\Nc|JIUTVyIE2gN{4yPiEQvF2= MnvPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
Caki1 M{[yUmN6fG:2b4jpZ4l1gSCjc4PhfS=> MkLYS2k2OCB;IEOuNVYh|ryP MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
786-0 NHzlUo1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{LwXmdKPTBiPTCzMlE3KM7:TR?= NEK5ZYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
LOXIMVI MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NYjoUpc1XEeLIE2gN{4yPiEQvF2= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
Caki1 NVrjRYJISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M{Xk[2dKPTBiPTCzMlE3KM7:TR?= MlPJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
OVCAR5 MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M323SWdKPTBiPTCzMlE3KM7:TR?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
RXF393 Mor0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MnjLS2k2OCB;IEOuNVYh|ryP MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
SNB75 NGXVdWFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NHvI[oRIUTVyIE2gN{4yPiEQvF2= MoC5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
OVCAR3 Ml7KRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MULHTVUxKD1iMz6xOkDPxE1? MnWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SNB19 MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NXLGOYFyT0l3MDC9JFMvOTZizszN NUDlTHNQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SK-MEL-5 MoPLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M1nkSXRIUSB;IEOuNVYh|ryP NV6zeYg3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
OVCAR4 M1vhW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M{C5O2dKPTBiPTCzMlE3KM7:TR?= NVrnTnl1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SK-MEL-2 Ml7LRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NFX3c4ZVT0liPTCzMlE3KM7:TR?= NYHDUW5JRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
BT549 MnnqRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MnSyS2k2OCB;IEOuNVYh|ryP NVixWphQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
MOLT4 NWS0U4pISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MkjpS2k2OCB;IEOuNVYh|ryP MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
K562 NH25XlRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NYOxeJFIT0l3MDC9JFMvOTZizszN NGOzPHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
HCC2998 M4LwPGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NWq0SZZbT0l3MDC9JFMvOTZizszN MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
HCC2998 NF7HU4pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MV;US2khRSB|LkG2JO69VQ>? Mo\DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
A549/ATCC MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NX7BcWlkT0l3MDC9JFMvOTZizszN M3W2W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
DU145 MkLtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M{XDUWdKPTBiPTCzMlE3KM7:TR?= NEiy[m49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SR MoT3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NELUcIRIUTVyIE2gN{4yPiEQvF2= M{LUPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
MCF7 NGHpOFhEgXSxdH;4bYNqfHliYYPzZZk> NXnyO|UyUUN3MDC9JFMvOThizszN NX3Y[5lGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5Nlc5ODFpPkK4PVI4QDBzPD;hQi=>
PC3 M4X1dGN6fG:2b4jpZ4l1gSCjc4PhfS=> M13ZbGlEPTBiPTCzMlE5KM7:TR?= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{N{iwNUc,Ojh7Mke4NFE9N2F-
MCF7 MWDDfZRwfG:6aXPpeJkh[XO|YYm= M1TDdWlEPTBiPTCzMlE5KM7:TR?= M4HIUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{e3NFA6Lz5{N{e3O|AxQTxxYU6=
A549 M4\MUWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NWPQT41wUUN3MDC9JFMvOTlizszN MnPKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5N{i5PVUoRjJ3N{e4PVk2RC:jPh?=
PC3 NFzrSGtEgXSxdH;4bYNqfHliYYPzZZk> NWXx[ZhHUUN3MDC9JFMvOjRizszN M4D0UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{e3NFA6Lz5{N{e3O|AxQTxxYU6=
HeLa M{\jR2Z2dmO2aX;uJIF{e2G7 MmPyTWM2OCB;IEOuN{DPxE1? NIrOe|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUKyOVcxPid-MUWyNlU4ODZ:L3G+
HeLa M{DIbGZ2dmO2aX;uJIF{e2G7 NWKxWXk2UUN3MDC9JFMvOyEQvF2= NYjVVppwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWyNlU4ODZpPkG1NlI2PzB4PD;hQi=>
LoVo MmXNR5l1d3SxeHnjbZR6KGG|c3H5 M3uzSWlEPTBiPTCzMlMh|ryP NXLrfnFJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OVQxOTdpPkKzOFU1ODF5PD;hQi=>
A375 NUPES5ZSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NXXCcokyUUN3MDC9JFMvOzZizszN NGjCZ3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[wNlY4PCd-Mkm2NFI3PzR:L3G+
HT-29 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M1rGSmlEPTBiPTCzMlM4KM7:TR?= NVrB[mx5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5PVE6OzhpPkK2PVkyQTN6PD;hQi=>
FLT3 gene-deficient U937 M2\F[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M4m0SGdKPTBiPTCzMlQh|ryP MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdyOES2PEc,OjF5MEi0Olg9N2F-
FLT3 negative U937 MljDR5l1d3SxeHnjbZR6KGG|c3H5 NEHmO|RIUTVyIE2gN{41KM7:TR?= NUXSdGFnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVg4ODlpPkKzOlE5PzB7PD;hQi=>
U937 MVXDfZRwfG:6aXPpeJkh[XO|YYm= MWPHTVUxKD1iMz60JO69VQ>? NGD5UW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC4NVAzOyd-Mk[wPFExOjN:L3G+
A375P Mnj6RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M3y4U2dKPTBiPTCzMlQh|ryP NXS1VYlsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0OVkyPDRpPkK5OFU6OTR2PD;hQi=>
ACHN MUnDfZRwfG:6aXPpeJkh[XO|YYm= Mki2TWM2OCB;IEOuOEDPxE1? NV\IUJhNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1NVc6ODhpPkK5OVE4QTB6PD;hQi=>
ACHN MVXDfZRwfG:6aXPpeJkh[XO|YYm= MXPJR|UxKD1iMz60JO69VQ>? NWPTN21sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyPVc3QDhpPkK5Nlk4Pjh6PD;hQi=>
HepG2 NUHFU|d7TnWwY4Tpc44h[XO|YYm= NUfzeG1kUUN3MDC9JFMvPCEQvF2= MoDIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyN{G4OlEoRjJ4MEexPFYyRC:jPh?=
A375P NFP6NG1EgXSxdH;4bYNqfHliYYPzZZk> NHXP[o1IUTVyIE2gN{41KM7:TR?= NILVblg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi3PFE6Oyd-MkS4O|gyQTN:L3G+
HepG2 MmXPR5l1d3SxeHnjbZR6KGG|c3H5 NVe0XFlEUUN3MDC9JFMvPDRizszN M2rIXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUK3PFAyLz5{OEmyO|gxOTxxYU6=
HepG2 MV3DfZRwfG:6aXPpeJkh[XO|YYm= MmnrTWM2OCB;IEOuOFQh|ryP M1vvZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{e3NFA6Lz5{N{e3O|AxQTxxYU6=
ACHN MWfDfZRwfG:6aXPpeJkh[XO|YYm= MnfoTWM2OCB;IEOuOUDPxE1? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd6NkSzOkc,Ojl5OE[0N|Y9N2F-
HepG2 M33ROGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NXOw[HdPUUN3MDC9JFMvPSEQvF2= NXixXZBSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0OlIzPjVpPkK1OFYzOjZ3PD;hQi=>
HT-29 NIfHfplEgXSxdH;4bYNqfHliYYPzZZk> MV3JR|UxKD1iMz62NUDPxE1? NFr6Nlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEiyOlgyPSd-MkS4NlY5OTV:L3G+
HT-29 Mo\XRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NHHkU3hKSzVyIE2gN{43OSEQvF2= NHzrdnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKxOlg1QSd-M{CyNVY5PDl:L3G+
HT-29 MX7DfZRwfG:6aXPpeJkh[XO|YYm= Ml;CTWM2OCB;IEOuOlEh|ryP MmrBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOE[yN|goRjJ3MEi2NlM5RC:jPh?=
HT-29 Ml\lR5l1d3SxeHnjbZR6KGG|c3H5 MmjYTWM2OCB;IEOuOlEh|ryP M3rQPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NESwPFc6Lz5{NUS0NFg4QTxxYU6=
MCF7 MVnBcpRq[2GwY3XyJIFkfGm4aYT5JIF{e2G7 M17QR2lEPTBiPTCzMlY1KM7:TR?= MkHjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NEm4OFEoRjJ7NUS5PFQyRC:jPh?=
Sf9 NYLiPZdFTnWwY4Tpc44h[XO|YYm= M1;DN2lEPTBiPTCzMlgh|ryP MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdyOES2PEc,OjF5MEi0Olg9N2F-
Sf9 M3K3N2Z2dmO2aX;uJIF{e2G7 MVTJR|UxKD1iMz64JO69VQ>? NUTocnZbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVg4ODlpPkKzOlE5PzB7PD;hQi=>
Sf9 M4\ITGZ2dmO2aX;uJIF{e2G7 NGO4TXlKSzVyIE2gN{45KM7:TR?= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB6MUCyN{c,OjZyOEGwNlM9N2F-
A2058 MmWzR5l1d3SxeHnjbZR6KGG|c3H5 NF;4XW9KSzVyIE2gN{45KM7:TR?= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjdyOEm4O{c,OjJ5MEi5PFc9N2F-
NCI-H460 MmDJR5l1d3SxeHnjbZR6KGG|c3H5 M1zvWmlEPTBiPTCzMlkh|ryP NEK2Vms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S1OFAyPyd-MkO0OVQxOTd:L3G+
SK-MEL-30 MmPSR5l1d3SxeHnjbZR6KGG|c3H5 MUfJR|UxKD1iMz65JO69VQ>? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR4MUiyO{c,Ojl2NkG4Nlc9N2F-
HT-29 NGHOVGNCdnSrY3HuZ4VzKGGldHn2bZR6KGG|c3H5 NW\LPHM{UUN3MDC9JFMvQTdizszN NWX5N2RCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFk5PDFpPkK5OVQ6QDRzPD;hQi=>
SF268 MkPXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mk\KWGdKKD1iMz65PEDPxE1? NFvSNpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
SNB75 MojUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYnUS2khRSB|Lkm4JO69VQ>? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
OVCAR3 M{DUSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFXX[YNVT0liPTCzMlk5KM7:TR?= NVHpflhWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
SNB19 MmXiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4H5SXRIUSB;IEOuPVgh|ryP M4XsWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
Hs 578T MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{e2S3RIUSB;IEOuPVgh|ryP NVO0d5ZZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
TK10 MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFPGSlVIUTVyIE2gN{46QCEQvF2= MoHjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
BT549 NUC2OZZVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV3US2khRSB|Lkm4JO69VQ>? NIjpc3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
Caki1 NYjhOVZuSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M2LQ[HRIUSB;IEOuPVgh|ryP NFvVdG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
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SK-MEL-188 NFT4WFVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MlnoTWM2OCB;IEWuOEDPxE1? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV4MUO5Nkc,OTd3NkGzPVI9N2F-
A375 NF:4V41CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{nKU2lEPTBiPTC1MlQh|ryP M1LVPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEW2OVQ5Lz5{MEC1OlU1QDxxYU6=
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HCT116 MnH6R5l1d3SxeHnjbZR6KGG|c3H5 NE\tSmpKSzVyIE2gOU43PSEQvF2= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJzNUixPEc,OjR{MUW4NVg9N2F-
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HepG2 MXrDfZRwfG:6aXPpeJkh[XO|YYm= MYPJR|UxKD1iNT63OEDPxE1? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR4MUOxPEc,OjV2NkGzNVg9N2F-
Bel7402 M{T0UGN6fG:2b4jpZ4l1gSCjc4PhfS=> NGXobJlKSzVyIE2gOU45KM7:TR?= M{nke|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEW0NFE4Lz5{M{S1OFAyPzxxYU6=
HT-29 MXLDfZRwfG:6aXPpeJkh[XO|YYm= NUXENFJEUUN3MDC9JFUvQSEQvF2= NV[3dIg1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4OlUzPzZpPkK4PFY2Ojd4PD;hQi=>
melanoma MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHrMd|JKSzVyIE2gOk4yKM7:TR?= NFHjNoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkO5NlgzPid-MU[zPVI5OjZ:L3G+
K562 NHf1SWRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NHLXOldIUTVyIE2gOk4zKM7:TR?= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdyOES2PEc,OjF5MEi0Olg9N2F-
HepG2 NF3LboFEgXSxdH;4bYNqfHliYYPzZZk> NGm2bGtKSzVyIE2gOk4zKM7:TR?= M{DPXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OE[1Nlc3Lz5{OEi2OVI4PjxxYU6=
A549 Ml;iRY51cWOjbnPldkBi[3Srdnn0fUBie3OjeR?= MYDJR|UxKD1iNj6yNUDPxE1? NEOwR3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW0PVg1OSd-Mkm1OFk5PDF:L3G+
SMMC7721 NGftZnpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NIXsVZBKSzVyIE2gOk4zOyEQvF2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{MUmyOEc,OjJ5MkG5NlQ9N2F-
HepG2 NILsd29CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MlrsTWM2OCB;IE[uN{DPxE1? MkD4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{KwO|EoRjJ|OUOyNFcyRC:jPh?=
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SK-MEL-2 NEPzUXpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkjqWGdKKD1iNj6zNUDPxE1? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
OVCAR5 Mkn3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYnUS2khRSB4LkOxJO69VQ>? MoTJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
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MALME-3M NHfWN|dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MYfUS2khRSB4LkOxJO69VQ>? M{jvdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
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HCC2998 NEPJbmRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NFewVIhNSzVyIE2gOk4{OSEQvF2= NVX6[5hKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
NCI-H522 NHrJTY1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NUn6dVZ[XEeLIE2gOk4{OSEQvF2= NYDVeHlqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
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LoVo MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MkfSTWM2OCB;IE[uOVYh|ryP MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDNzNUG5Nkc,OjR|MUWxPVI9N2F-
A375 MkjnSpVv[3Srb36gZZN{[Xl? NV3mW|N1UUN3MDC9JFYvPTl7IN88US=> M4jGT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEC3OVA4Lz5{MUiwO|UxPzxxYU6=
HCT116 M13lb2Z2dmO2aX;uJIF{e2G7 M4rWSWdKPTBiPTC2MlYh|ryP M2DHTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MkK1O|A3Lz5zNUKyOVcxPjxxYU6=
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PC3 M4jiXWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3zqXGlEPTBiPTC2Mlgh|ryP MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB{MUm2O{c,OjNyMkG5Olc9N2F-
SGC7901 NIjhVmREgXSxdH;4bYNqfHliYYPzZZk> MmPyTWM2OCB;IE[uPUDPxE1? NXHlTWF[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OVQxOTdpPkKzOFU1ODF5PD;hQi=>
OS-RC2 NWfwSXViS3m2b4TvfIlkcXS7IHHzd4F6 MUfJR|UxKD1iNzFOwG0> M1G4N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUG3PVA5Lz5{OUWxO|kxQDxxYU6=
OS-RC2 NF\3e3lEgXSxdH;4bYNqfHliYYPzZZk> NFfwe5hKSzVyIE2gO{DPxE1? NHHXUng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUK5O|Y5QCd-MkmyPVc3QDh:L3G+
COLO205 Ml3PRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgbJVu[W5? MU\JR|UxKD1iNz6wOEDPxE1? NXfpdZFHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyOFI2PTNpPkK4NlQzPTV|PD;hQi=>
rhabdomyosarcoma M{LiemN6fG:2b4jpZ4l1gSCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHu Mnr1R2M2OCB;IEeuNFUh|ryP MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzJ6OEG4Okc,Ojd{OEixPFY9N2F-
HuH7 NVrke49bS3m2b4TvfIlkcXS7IHHzd4F6 MoH2TWM2OCB;IEeuNUDPxE1? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF3OUS4N{c,OjZzNUm0PFM9N2F-
MDA-MB-231 MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3vWO2lEPTBiPTC3MlE5KM7:TR?= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{MUmyOEc,OjJ5MkG5NlQ9N2F-
FLT3-negative K562 M3W5dWN6fG:2b4jpZ4l1gSCjc4PhfS=> NV7QdJJyT0l3MDC9JFcvOyEQvF2= NF3wclE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xPFcxQSd-MkO2NVg4ODl:L3G+
K562 NWi5cFRKTnWwY4Tpc44h[XO|YYm= MnHLS2k2OCB;IEeuN{DPxE1? Ml7HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyOEGwNlMoRjJ4MEixNFI{RC:jPh?=
K562 MnezSpVv[3Srb36gZZN{[Xl? NXzLS2QzT0l3MDC9JFcvOyEQvF2= NXjZendVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wPFExOjNpPkK2NFgyODJ|PD;hQi=>
MCF7 MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3rZTGlEPTBiPTC3MlM{KM7:TR?= MmfDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESyNVkoRjJ|NkS0NlE6RC:jPh?=
A549 Ml74R5l1d3SxeHnjbZR6KGG|c3H5 MkXMWGdKKD1iNz6zOkDPxE1? NEC5[Yg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
WI38 M2jDOGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4rRfGlEPTBiPTC3MlU1KM7:TR?= Mlf0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6Mk[4NVUoRjJ2OEK2PFE2RC:jPh?=
A375 NVzCTZdkS3m2b4TvfIlkcXS7IHHzd4F6 NVXN[XY5UUN3MDC9JFcvPTZizszN NXHtSIdRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVU5OThpPkK0NlE2QDF6PD;hQi=>
MDA-MB-231 M2TPVWN6fG:2b4jpZ4l1gSCjc4PhfS=> MVHJR|UxKD1iNz62NkDPxE1? Mn3wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzOEG0NVQoRjJyMUixOFE1RC:jPh?=
786-0 NUDtN4JUS3m2b4TvfIlkcXS7IHHzd4F6 NYi5Old[XEeLIE2gO{43OiEQvF2= NYf0fW9pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
HS27 NInz[HRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NEHEN3NKSzVyIE2gO{45KM7:TR?= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh3N{m2N{c,OTl6NUe5OlM9N2F-
HS27 MnvaR5l1d3SxeHnjbZR6KGG|c3H5 NGjPPIhKSzVyIE2gO{45KM7:TR?= M4TvVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEm3N|Y3Lz5zOUi5O|M3PjxxYU6=
HCT116 NImzeYJEgXSxdH;4bYNqfHliYYPzZZk> NIe2epdKSzVyIE2gO{45KM7:TR?= NGP1dFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4N|U6Oid-MkK0PFM2QTJ:L3G+
HS27 MlXVRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M3T3UGlEPTBiPTC3Mlg2KM7:TR?= NXLoTo5TRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0OlQ5QDdpPkG5OFY1QDh5PD;hQi=>
HS27 NHrUUoRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NEC2NnhIUTVyIE2gO{45PSEQvF2= NXr0NplrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzOVM2PzFpPkKxN|U{PTdzPD;hQi=>
A549/ATCC MkfmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mlu3WGdKKD1iNz65OEDPxE1? NH7EWpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
DU145 MmTQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MU\US2khRSB5Lkm0JO69VQ>? M{LVVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
NCI/ADR-RES Mlm0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHvDd3lVT0liPTC3Mlk1KM7:TR?= NUDnS|NTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
MCF7 MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYLUS2khRSB5Lkm0JO69VQ>? MnnZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
PC3 M4r0eGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NUTTOI1yXEeLIE2gO{46PCEQvF2= NIjJcYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
UO31 NF\ydnFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MYDUS2khRSB5Lkm0JO69VQ>? NGHEOI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
NCI-ADR-RES MnXJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NIn1U4VVT0liPTC3Mlk1KM7:TR?= NFm4XIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
LOXIMVI MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3KxWWxEPTBiPTC3Mlk1KM7:TR?= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
SK-MEL-28 M2i4d2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NV\3b2FyXEeLIE2gO{46PCEQvF2= NIjwXHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
KM12 MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MXLUS2khRSB5Lkm0JO69VQ>? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
COLO205 NI\vNGdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NIf1UYZVT0liPTC3Mlk1KM7:TR?= NYjaNXY1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
HT-29 NIq3XIRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{jMfHRIUSB;IEeuPVQh|ryP NUfq[mtuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
NCI-H226 M1PqZ2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MXjUS2khRSB5Lkm0JO69VQ>? NGO2SZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
HOP62 NX[yWFJiSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NE\tWlBVT0liPTC3Mlk1KM7:TR?= M3Hke|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
T47D MlvmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NHLSb5RVT0liPTC3Mlk1KM7:TR?= M{Xid|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
MDA-MB-468 NYjCSY5YSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M2HadnRIUSB;IEeuPVQh|ryP MkOwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
EKVX MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Ml6yWGdKKD1iNz65OEDPxE1? NG\ab5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
MCF7 NX;3bXZGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MlrBWGdKKD1iNz65OEDPxE1? MnzKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
Hs 578T M334NmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NUjQWZEyXEeLIE2gO{46PCEQvF2= NVjDSXpzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
MGC803 M2W2fGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 Mn7pTWM2OCB;IEeuPVkh|ryP M{\IXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NU[wNFQ6Lz5{NkW2NFA1QTxxYU6=
HCT116 M2LGZ2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M16yW2lEPTBiPTC4MlA5KM7:TR?= NITOe4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NES0NFQ4QSd-MkS0OFA1Pzl:L3G+
PC3 NEjNe|VEgXSxdH;4bYNqfHliYYPzZZk> MnXTTWM2OCB;IEiuNFgh|ryP M161UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MESzNlY5Lz5{N{C0N|I3QDxxYU6=
HCT116 MkjaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MoC3TWM2OCB;IEiuNFgh|ryP MmPVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESyNVkoRjJ|NkS0NlE6RC:jPh?=
WM266.4 MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NFT5V|FIUTVyIE2gPE4yKM7:TR?= NGTDUpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CyOVk6Pid-MkOwNlU6QTZ:L3G+
WM266.4 NViyU3FYSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NHjMUIlIUTVyIE2gPE4yOiEQvF2= NECzR|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW4N|Y3QSd-MkK1PFM3Pjl:L3G+
Ketr3 NI\6XFFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MVTJR|UxKD1iOD6yO{DPxE1? M1e5U|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkG2PFQ6Lz5|MEKxOlg1QTxxYU6=
A375 NWnxeopuSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NYnzWlVIUUN3MDC9JFgvOjdizszN NVL5bYpJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNVY5PDlpPkOwNlE3QDR7PD;hQi=>
HepG2 M{XuRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MXzJR|UxKD1iOD6yO{DPxE1? MkmyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MU[4OFkoRjNyMkG2PFQ6RC:jPh?=
MX1 NEHsVotCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MXzJR|UxKD1iOD6yO{DPxE1? M{niVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkG2PFQ6Lz5|MEKxOlg1QTxxYU6=
MX1 NWfmNlF4S3m2b4TvfIlkcXS7IHHzd4F6 MXLJR|UxKD1iOD6yO{DPxE1? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ5NUGzOUc,OjR4N{WxN|U9N2F-
WM266.4 NGnP[JhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3\icWdKPTBiPTC4MlMh|ryP M1HrV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{[xOlg3Lz5{MkO2NVY5PjxxYU6=
PLC/PRF/5 MlzYR5l1d3SxeHnjbZR6KGG|c3H5 NFviOGhKSzVyIE2gPE4{KM7:TR?= M1e2bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUOxNFU{Lz5{MUWzNVA2OzxxYU6=
A375 NYPMPZdmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MmPjTWM2OCB;IEiuN|Mh|ryP M4m5cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OEi2N|I1Lz5{OUi4OlMzPDxxYU6=
HCT116 MWHDfZRwfG:6aXPpeJkh[XO|YYm= Mn7qTWM2OCB;IEiuOFEh|ryP Mmm3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4M{G3PFgoRjJ7NkOxO|g5RC:jPh?=
WI38 NXW1UoZES3m2b4TvfIlkcXS7IHHzd4F6 NYfrdVltUUN3MDC9JFgvPDJizszN M3\YXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUmxPVM5Lz5{Nkm5NVk{QDxxYU6=
HepG2 MYnDfZRwfG:6aXPpeJkh[XO|YYm= MY\JR|UxKD1iOD60NkDPxE1? NY\x[oxMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexOlIyOjNpPkK3NVYzOTJ|PD;hQi=>
HepG2 MYfDfZRwfG:6aXPpeJkh[XO|YYm= MoXjTWM2OCB;IEiuOFIh|ryP MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh5MUmwPUc,OjN6N{G5NFk9N2F-
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HepG2 NIHmZYlEgXSxdH;4bYNqfHliYYPzZZk> MUPJR|UxKD1iOD62O{DPxE1? NFO2dnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[3OVE{PSd-MkS2O|UyOzV:L3G+
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MCF7 MmjTR5l1d3SxeHnjbZR6KGG|c3H5 MkPjTWM2OCB;IEmuNVIh|ryP MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDNyMEmyNEc,OjR|MEC5NlA9N2F-
HepG2 NWnQZnhOSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MlP3TWM2OCB;IEmuNVQh|ryP NEjRdG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW2NFA1QSd-Mk[1OlAxPDl:L3G+
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MGC803 NHPpbohCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MVrJR|UxKD1iOT6yJO69VQ>? NGnjTWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUCzNlA{OSd-MkmwN|IxOzF:L3G+
SKOV3 M2fkcGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1LFO2lEPTBiPTC5MlI2KM7:TR?= MkfMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MEC5NlAoRjJ2M{CwPVIxRC:jPh?=
RS4:11 M{i1V2Z2dmO2aX;uJIF{e2G7 MmTaS2k2OCB;IEmuN{DPxE1? NHLBS3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC4NVAzOyd-Mk[wPFExOjN:L3G+
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MIAPaCa2 MnjoRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MXXJR|UxKD1iOT6zNkDPxE1? M371cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEOyNFMyLz5{OUCzNlA{OTxxYU6=
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RS4:11 M{HVfWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NHjFTFJIUTVyIE2gPU41KM7:TR?= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdyOES2PEc,OjF5MEi0Olg9N2F-
Hep3B M{DBSWN6fG:2b4jpZ4l1gSCjc4PhfS=> M{fpdmlEPTBiPTC5MlQh|ryP NITjPFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEi2OVI4Pid-Mki4OlUzPzZ:L3G+
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SMMC7721 MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Mk\kTWM2OCB;IEmuPVYh|ryP MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ|N{GyN{c,OjV4M{exNlM9N2F-
MCF7 NVfNWWpNS3m2b4TvfIlkcXS7IHHzd4F6 MX;US2khRSB7Lkm3JO69VQ>? NH73fFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
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ACHN MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mk\jWGdKKD1iMUCg{txO MoKyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
TK10 NIDm[3lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnrmWGdKKD1iMUCg{txO NVHBZlQ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
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DU145 M3LITGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NVfGbVdoXEeLIE2gNVAh|ryP NFn4UW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
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Bel7402 NYnQNHV1S3m2b4TvfIlkcXS7IHHzd4F6 NFOxfZFKSzVyIE2gNVAvOjZizszN NHTNSoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWwOFIxPCd-MkG1NFQzODR:L3G+
Bel7402 NUjqUnZkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1PaNGlEPTBiPTCxNE4{OSEQvF2= NFr2VHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGwNlE4PSd-MkmxNFIyPzV:L3G+
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SNB75 NXPpRY9bS3m2b4TvfIlkcXS7IHHzd4F6 NHqyUnFVT0liPTCxNE41OiEQvF2= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
A431 M2\tRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MnvLTWM2OCB;IEGwMlQ3KM7:TR?= M4OzelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEOyNFMyLz5{OUCzNlA{OTxxYU6=
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GES-1 M13kXGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2fPfWlEPTBiPTCxNE43QCEQvF2= NU\QcYp7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexOlIyOjNpPkK3NVYzOTJ|PD;hQi=>
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Hep3B NXSxcWdIS3m2b4TvfIlkcXS7IHHzd4F6 NYjkTZJpUUN3MDC9JFEyNjJizszN NULTVmZbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizOFI1ODBpPkK4N|QzPDByPD;hQi=>
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SGC7901 NYfqT3JjS3m2b4TvfIlkcXS7IHHzd4F6 M1X2fWlEPTBiPTCxNU42KM7:TR?= NHfYT2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOwNFkzOCd-MkSzNFA6OjB:L3G+
HeLa M2W2N2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M2HCbWlEPTBiPTCxNk4xOSEQvF2= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTFyM{i3N{c,OjlzMEO4O|M9N2F-
PANC1 M2T2S2N6fG:2b4jpZ4l1gSCjc4PhfS=> NXLZU2VpUUN3MDC9JFEzNjNizszN MoLQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MEC5NlAoRjJ2M{CwPVIxRC:jPh?=
HepG2 MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NGD3NJpKSzVyIE2gNVIvPTRizszN M4DHOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEOyNFMyLz5{OUCzNlA{OTxxYU6=
A549 NFPCXZVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MWDJR|UxKD1iMUKuOVQh|ryP NILuXY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[0OFIyQSd-MkO2OFQzOTl:L3G+
Caki1 NUTxN2VyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHq5ZWJVT0liPTCxNk42QSEQvF2= NXjBOZJ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
OVCAR8 NUnIN5gzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2rQeHRIUSB;IEGyMlU6KM7:TR?= MkHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
SKOV3 M4HaN2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NGLkeHhVT0liPTCxNk43KM7:TR?= NFfxb5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
ACHN MnPzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NGfHUphVT0liPTCxNk43KM7:TR?= M2D3dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
OVCAR3 M1zXeGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M1rVdHRIUSB;IEGyMlYh|ryP NEn4dIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
OVCAR4 NF;2WJJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NGDVTY9VT0liPTCxNk43KM7:TR?= NILYeZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
HCT15 M3XxdGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NH7KfmxVT0liPTCxNk43KM7:TR?= Mn\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SW620 NHTjZnhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MWfUS2khRSBzMj62JO69VQ>? NEjYcZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
A549/ATCC MmnxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NIDNWGpVT0liPTCxNk43KM7:TR?= M1y0SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
MDA-MB-468 M1zqVWN6fG:2b4jpZ4l1gSCjc4PhfS=> NEe4R2NVT0liPTCxN{4xQSEQvF2= M2juS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
SK-MEL-28 MXTDfZRwfG:6aXPpeJkh[XO|YYm= M1TJU3RIUSB;IEGzMlM6KM7:TR?= M3XEZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
A549 MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MlTDTWM2OCB;IEGzMlY1KM7:TR?= NFvBW449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW2NFA1QSd-Mk[1OlAxPDl:L3G+
A375 MmG1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgbJVu[W5? MYTJR|UxKD1iMUOuOlQh|ryP MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ2MkW1N{c,Ojh{NEK1OVM9N2F-
A375 MoHnRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MX;JR|UxKD1iMUOuOlQh|ryP NXTCblF[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0OlIzPjdpPkK1OFYzOjZ5PD;hQi=>
K562 NV[2e4VUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NYDoSJJoUUN3MDC9JFE{Njh3IN88US=> NVfvWW1sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTlpPkKzOlQ1OjF7PD;hQi=>
Hep3B Mn:5R5l1d3SxeHnjbZR6KGG|c3H5 NE\DNmxKSzVyIE2gNVQvODhizszN M3;JUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUC0NlA1Lz5{MUWwOFIxPDxxYU6=
T47D NIHmbphEgXSxdH;4bYNqfHliYYPzZZk> MYjUS2khRSBzND6zPEDPxE1? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
NCI-H226 MYDDfZRwfG:6aXPpeJkh[XO|YYm= NIHZOlNVT0liPTCxOE41OiEQvF2= M3LxW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
MDA-MB-231 Ml[1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NWTKVY5KUUN3MDC9JFE1NjZ{IN88US=> NFTEeFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NES0NFQ4QSd-MkS0OFA1Pzl:L3G+
MDA-MB-231 MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MYXJR|UxKD1iMUSuOlIh|ryP MljsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESyNVkoRjJ|NkS0NlE6RC:jPh?=
NCI-H522 NIHGVGxEgXSxdH;4bYNqfHliYYPzZZk> MojHWGdKKD1iMUSuPFIh|ryP NWrxb4lVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
SK-MEL-2 NWHkRoQ1S3m2b4TvfIlkcXS7IHHzd4F6 MX\US2khRSBzND64OUDPxE1? M1TOUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
OS-RC2 M1HCPGN6fG:2b4jpZ4l1gSCjc4PhfS=> NELUXYNKSzVyIE2gNVUh|ryP MnjiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl5OE[0N|YoRjJ7N{i2OFM3RC:jPh?=
HepG2 Mm\iRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NGrZWlFKSzVyIE2gNVUh|ryP MlfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzMEO4O|MoRjJ7MUCzPFc{RC:jPh?=
fibroblast NWPibYxXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NIn4U5dKSzVyIE2gNVUvOSEQvF2= NFTLbXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES3O|UxPSd-MUi0O|c2ODV:L3G+
HT-29 MnrMR5l1d3SxeHnjbZR6KGG|c3H5 M2faTmlEPTBiPTCxOU4zKM7:TR?= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ5NUGzOUc,OjR4N{WxN|U9N2F-
U87MG NXfRd29OS3m2b4TvfIlkcXS7IHHzd4F6 NVLIUY1zUUN3MDC9JFE2NjV5IN88US=> MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh{NkixOUc,OjR6Mk[4NVU9N2F-
BT549 MkLQRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NX7TNGcyVEN3MDC9JFE2NjhizszN M{HlWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
GES-1 MkSyR5l1d3SxeHnjbZR6KGG|c3H5 MXzJR|UxKD1iMUWuPEDPxE1? NVnhS5cxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4O|E6ODlpPkKzPFcyQTB7PD;hQi=>
SNB19 M{jSdmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MmnMWGdKKD1iMUWuPFUh|ryP NITBNpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
IGROV1 M{X0VGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MYLUS2khRSBzNT65JO69VQ>? NWjPeJZJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
HCT116 NFHiN4xCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M4rmVWxEPTBiPTCxOU46KM7:TR?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
OS-RC2 NGfXfm5EgXSxdH;4bYNqfHliYYPzZZk> MWjJR|UxKD1iMU[g{txO NUjMT4lsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OVQxOTdpPkKzOFU1ODF5PD;hQi=>
A375 M2OxOWN6fG:2b4jpZ4l1gSCjc4PhfS=> M{PiZWlEPTBiPTCxOk4zPCEQvF2= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR4MUOxPEc,OjV2NkGzNVg9N2F-
SKOV3 NXnRVJlMS3m2b4TvfIlkcXS7IHHzd4F6 MUnUS2khRSBzNj6zOkDPxE1? MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
WM1361 NV:xfpl2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M4m2emlEPTBiPTCxOk41PCEQvF2= NYr4eG9tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2NFI3PzRpPkK5OlAzPjd2PD;hQi=>
MKN28 MnHLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MkPrTWM2OCB;IEG3JO69VQ>? M2rme|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEOyNFMyLz5{OUCzNlA{OTxxYU6=
SMMC7721 NIrTUZREgXSxdH;4bYNqfHliYYPzZZk> M{TUOGlEPTBiPTCxO{4{KM7:TR?= NWDTVYhCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1NFQzODRpPkKxOVA1OjB2PD;hQi=>
UACC257 MVvDfZRwfG:6aXPpeJkh[XO|YYm= NHzSOmFVT0liPTCxO{4{OyEQvF2= NYDOVYRPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
EAhy926 M1TqS2FvfGmjbnfpc4dmdmmlIHHjeIl3cXS7IHHzd4F6 NWm0SZA1UUN3MDC9JFE5NjV{IN88US=> NHXGflU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUCzNlA{OSd-MkmwN|IxOzF:L3G+
SMMC7721 MVTDfZRwfG:6aXPpeJkh[XO|YYm= MknZTWM2OCB;IEG4Mlch|ryP NYPpXnpSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNFA6OjBpPkK0N|AxQTJyPD;hQi=>
Ketr3 MmrzR5l1d3SxeHnjbZR6KGG|c3H5 M{jLUmlEPTBiPTCxPE45KM7:TR?= NFvn[|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[3OVE{PSd-MkS2O|UyOzV:L3G+
NCI-H522 NHPqNoJEgXSxdH;4bYNqfHliYYPzZZk> MU\JR|UxKD1iMUmuNlYh|ryP MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR4MUOxPEc,OjV2NkGzNVg9N2F-
A549 NHrG[GdEgXSxdH;4bYNqfHliYYPzZZk> MlPvTWM2OCB;IEG5MlU1KM7:TR?= MkLkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzNkKxNlMoRjJ5MU[yNVI{RC:jPh?=
SH-SY5Y Ml3ZR5l1d3SxeHnjbZR6KGG|c3H5 NU\zdHh3UUN3MDC9JFE6NjV2IN88US=> NYLTRVFQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4O|E6ODlpPkKzPFcyQTB7PD;hQi=>
MGC803 NYfvWnd{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NWrFVnA{UUN3MDC9JFE6Njl{IN88US=> MmHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzMEO4O|MoRjJ7MUCzPFc{RC:jPh?=
EKVX MkfNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIW2NVJVT0liPTCxPU46PSEQvF2= M4XmT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
OVCAR5 M3Xw[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MXTUS2khRSB{MDFOwG0> NEjvTmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
UACC62 NYPmSVI6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MUPMR|UxKD1iMkCg{txO NWfUWHoxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
UACC257 NUnvNYVQSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NWPEZlhLVEN3MDC9JFIxKM7:TR?= M32xO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
MDA-MB-231 NHizUHBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NEPv[FZNSzVyIE2gNlAh|ryP NGLKWII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
U87 MUfDfZRwfG:6aXPpeJkh[XO|YYm= Ml7qTWM2OCB;IEKxMlA4KM7:TR?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODR|NUS3PUc,OjB2M{W0O|k9N2F-
EJ MnTCR5l1d3SxeHnjbZR6KGG|c3H5 NXrTR5NjUUN3MDC9JFIzNjlizszN MmrOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MEC5NlAoRjJ2M{CwPVIxRC:jPh?=
HCT116 NEfEfWNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M3XIT2lEPTBiPTCyN{4{OSEQvF2= NVPtO2JsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2NFI3PzRpPkK5OlAzPjd2PD;hQi=>
HOP62 MVXDfZRwfG:6aXPpeJkh[XO|YYm= MULUS2khRSB{Mz61OUDPxE1? M{fjXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
MDA-MB-231 NFzzSpdEgXSxdH;4bYNqfHliYYPzZZk> MmPHWGdKKD1iMkOuPVMh|ryP NFv3NWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
PC3 NIGzZmdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmjNTWM2OCB;IEK0MlIh|ryP MlzaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2NEC0O|koRjJ2NESwOFc6RC:jPh?=
PC3 MnP1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NWr1dIo2UUN3MDC9JFI1NjJizszN MkXpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESyNVkoRjJ|NkS0NlE6RC:jPh?=
EAhy926 NHvoVmVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2KwOmlEPTBiPTCyOE4{PiEQvF2= M176PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6ME[4OVk6Lz5{OEC2PFU6QTxxYU6=
EAhy926 M{PMdGFvfGlvYX7nbY9o\W6rYzDhZ5Rqfmm2eTDpckBpfW2jbh?= MWrJR|UxKD1iMkSuN|Yh|ryP MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTFyMkG3OUc,OjlzMEKxO|U9N2F-
U251 MljqR5l1d3SxeHnjbZR6KGG|c3H5 M1izd2lEPTBiPTCyOE44OSEQvF2= M{iwc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEO1OFc6Lz5{MESzOVQ4QTxxYU6=
NIH/3T3 NWDFeZJ6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MXnJR|UxKD1iMkSuO|Uh|ryP M1m2TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUmyOlI5Lz5{MUW5NlYzQDxxYU6=
NIH/3T3 M4Xmc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M{nXfGlEPTBiPTCyOE44PSEQvF2= NXXIRY5VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2OFc4OjBpPkKyOlQ4PzJyPD;hQi=>
DU145 MXXDfZRwfG:6aXPpeJkh[XO|YYm= MUDJR|UxKD1iMkSuPVEh|ryP NGDRTmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G2NlEzOyd-MkexOlIyOjN:L3G+
DU145 M{niUWN6fG:2b4jpZ4l1gSCjc4PhfS=> NGnwNZVKSzVyIE2gNlQvQTFizszN MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh5MUmwPUc,OjN6N{G5NFk9N2F-
U251 NV32TXZ{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Ml\LUGM2OCB;IEK1MlEh|ryP MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
M14 NIPTO3hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MnjBUGM2OCB;IEK1MlEh|ryP NUS0Z5hzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
NCI-H522 NVTnUldjSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NGPsV5pNSzVyIE2gNlUvOSEQvF2= M1K1eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
OVCAR4 Mkf4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NILYUIhVT0liPTCyOU4yOiEQvF2= MmLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
SH-SY5Y MWHDfZRwfG:6aXPpeJkh[XO|YYm= NWPZNoxYUUN3MDC9JFI4NjdzIN88US=> M2nt[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MU[yNVI{Lz5{N{G2NlEzOzxxYU6=
A549 NW\GUHpoS3m2b4TvfIlkcXS7IHHzd4F6 Ml\HTWM2OCB;IEK3MlcyKM7:TR?= NVPWN2hIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4O|E6ODlpPkKzPFcyQTB7PD;hQi=>
PLC/PRF/5 M1zSfWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4PMemlEPTBiPTCyPU46KM7:TR?= NX\PbpN[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixNFk6PDhpPkK4NVA6QTR6PD;hQi=>
SK-MEL-5 MnXzR5l1d3SxeHnjbZR6KGG|c3H5 MoHtWGdKKD1iM{GuNlYh|ryP MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
A498 NHOyXHlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NF3DTnFNSzVyIE2gN|EvPiEQvF2= NVmybZVoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SK-MEL-28 MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MUnMR|UxKD1iM{GuOkDPxE1? NYT1OVFiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
KM12 MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NGK5fYNNSzVyIE2gN|EvPiEQvF2= MoDmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
COLO205 MkHORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NHnk[WpNSzVyIE2gN|EvPiEQvF2= NVjDWG5uRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
NCI-H226 Mn63RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NH;SWYZNSzVyIE2gN|EvPiEQvF2= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
SF295 M2S2XmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MYPMR|UxKD1iM{GuOkDPxE1? MofkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
HOP62 M4HsTmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MU\MR|UxKD1iM{GuOkDPxE1? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
T47D NWDYZ|d[SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M1vkWGxEPTBiPTCzNU43KM7:TR?= NEXjcFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
MHCC97L MkX4R5l1d3SxeHnjbZR6KGG|c3H5 MmXqTWM2OCB;IEO0MlQyKM7:TR?= NIOyc4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGwPVk1QCd-MkixNFk6PDh:L3G+
MDA-MB-231 NVTJOW91SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MVLJR|UxKD1iM{Wg{txO NGHuTXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOxOVE6Oid-MkSzNVUyQTJ:L3G+
MDA-MB-231 NGHYdmxEgXSxdH;4bYNqfHliYYPzZZk> M2DHe2lEPTBiPTCzOkDPxE1? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR6M{W5Nkc,OjJ2OEO1PVI9N2F-
B16-BL6 NV\CRpZsS3m2b4TvfIlkcXS7IHHzd4F6 MmruTWM2OCB;IEO2MlQ5KM7:TR?= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ|MUe4PEc,Ojl4M{G3PFg9N2F-
UO31 MUnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MknQUGM2OCB;IEO5Mlgh|ryP NG[wS3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SN12C MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MYnMR|UxKD1iM{muPEDPxE1? M2rh[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
RXF393 MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MlnRUGM2OCB;IEO5Mlgh|ryP NW\FTHFNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SNB75 Mo\pRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? Ml7WUGM2OCB;IEO5Mlgh|ryP MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
SF268 NEH6XVRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MV\MR|UxKD1iM{muPEDPxE1? M2SzXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
NCI-H23 MlzKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NELjeZFNSzVyIE2gN|kvQCEQvF2= NHLIeGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
HT-29 MojBRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NVXteZdHVEN3MDC9JFM6NjhizszN MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
HOP92 MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NVT6U|d1VEN3MDC9JFM6NjhizszN NXH4b|dURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
NCI-H460 MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NXHK[YR4VEN3MDC9JFM6NjhizszN NH;zVJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SW620 MnjRRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MXLMR|UxKD1iM{muPEDPxE1? M3K3PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
MDA-MB-468 NFXhfnFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NXrIPZZoVEN3MDC9JFM6NjhizszN MnT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
MALME-3M M1izNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{jyVnRIUSB;IEO5MlgyKM7:TR?= NHzSPGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
LC3-I / LC-3II / ATG5; 

PubMed: 23392173     


Sorafenib induces the conversion of LC3 in a dose-dependent manner. PLC5, Hep3B, SK-Hep1 and HepG2 were exposed to sorafenib at the indicated doses for 16 h and the expression levels of LC3-II were analyzed by western blot.

p-STAT3 / STAT3 / Mcl-1; 

PubMed: 23392173     


Effects of sorafenib on STAT3-related proteins in HCC cells. The cells were treated with sorafenib at the indicated dose for 16 h. 

β-catenin / Survivin / Mcl-1 / PTMA; 

PubMed: 26517516     


Co-inhibition of β-catenin and PTMA by sorafenib in HCC cells. Cell lines indicated on top were treated or not with 10 μM sorafenib for 24 hrs and processed for immuno-blotting. IC50 values (the concentration of sorafenib that inhibits 50% of cell growth) for each cell line are indicated below the panels.

pERK / ERK; 

PubMed: 22286758     


Western blot analysis of p-ERK (T202/Y204) and ERK at indicated time points in HCT116 cells treated with 20 μmol/L sorafenib.

p-PKM2(y105) / PMK2 / Caspase-9; 

PubMed: 26959741     


Sorafenib downregulates the p-PKM2 (Y105) at the indicated doses after treatment for 24 h.

RET(pY1016) / VEGFR2(pY1214) / MEK1(pT292) / ERK(pY204); 

PubMed: 22941289     


Sorafenib affected the phosphorylation of receptor tyrosine kinase RET and VEGFR2, as well as MEK/ERK kinases signaling cascades in three cell lines. Three cell lines were treated by sorafenib with two concentration gradients, 1 and 5 μmol/L/L, and then collected after 2, 4, and 8 h, cells without sorafenib treatment were as the controls (0 h). Total proteins were extracted and quantified to be used in Western blot assays. (A) Sorafenib inhibited RET and VEGFR2 phosphorylation dose-dependently while activated MEK and ERK phosphorylation in A549 cells. (B) Sorafenib also inhibited RET and VEGFR2 phosphorylation, and slightly activated MEK and ERK phosphorylation in HeLa cells. (C) Sorafenib activated the phosphorylation of RET, VEGFR2, and MEK, but inhibited ERK phosphorylation in HepG2 cells.

Cyclin D1; 

PubMed: 26039995     


Dose-escalation effects of sorafenib or SC-1 for 24 h on STAT3-related proteins in HSC-T6 and LX2 cells.

23392173 26517516 22286758 26959741 22941289 26039995
Growth inhibition assay
Cell viability; 

PubMed: 26039995     


Dose-escalation and time-dependent effects of sorafenib for 24 or 48 h on cell viability in HSC-T6, LX2, and mouse primary HSCs. Circles, mean; bars, SE (n = 3).

26039995
Immunofluorescence
p65; 

PubMed: 22286758     


HCT116 cells were treated with 20 μmol/L sorafenib or 10 ng/mL TNF-α for 3 hours then fixed. Immunofluorescence was carried out as described in the Materials and Methods for p65 (green) and DAPI (blue). Representative pictures (400×) are shown.

cytochrome c; 

PubMed: 22278289     


Immunoflourescent staining and quantification of mitochondrial membrane potential (appearing in red, mitotracker) and cytochrome c (appearing in green, FITC) in 22Rv1 and PC3 treated with 20 μM sorafenib for 24 h.

22286758 22278289
ELISA
TGF-beta / CD206; 

PubMed: 26158762     


In Macrophage, TGF-β secretion and CD206 were confirmed by ELISA.

Caspase-9 / Caspase-3; 

PubMed: 30923462     


Caspase-9 and caspase-3 activities were measured via ELISA assay. FCCP, an activator of mitophagy, was added into the medium of sorafenib-treated cells to activate mitophagy. Adenovirus-loaded LATS2 (Ad-LATS2) was transfected into HepG2 cells in the presence of sorafenib. *p < 0.05 vs. control group; #p < 0.05 vs. Sorafenib + Ad-cont group; #p < 0.05 vs. Sorafenib + Ad-LATS2 group.

26158762 30923462
In vivo Oral administration of Sorafenib (~60 mg/kg) demonstrates broad spectrum, dose-dependent anti-tumor activity against a variety of human tumor xenograft models including MDA-MB-231, Colo-205, HT-29, DLD-1, NCI-H460, and A549, with no evidence of toxicity. In association with the anti-tumor efficacy, Sorafenib treatment potently inhibits MEK 1/2 phosphorylation and pERK 1/2 levels in HT-29 and MDA-MB-231 xenografts but not in Colo-205 xenografts, and significantly suppresses tumor microvessel area (MVA) and microvessel density (MVD) in MDA MB-231, HT-29 and Colo-205 tumor xenografts. [1] Sorafenib treatment produces dose-dependent growth inhibition of PLC/PRF/5 tumor xenografts in SCID mice with TGIs of 49% and 78% at 10 mg/kg and 30 mg/kg, respectively, consistent with the inhibition of ERK and eIF4E phosphorylation, reduction of the microvessel area, and induction of tumor cell apoptosis. [2] Sorafenib sensitizes bax-/- cells to TRAIL in a dose-dependent manner, through a mechanism involving down-regulating NF-κB mediated Mcl-1 and cIAP2 expression. Combining Sorafenib (30-60 mg/kg) with TRAIL (5 mg/kg) show dramatic efficacy in TRAIL-resistant HCT116 bax-/- and HT29 tumor xenografts. [3]

Protocol

Kinase Assay:

[1]

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Biochemical assays:

Recombinant baculoviruses expressing Raf-1 (residues 305–648) and B-Raf (residues 409–765) are purified as fusion proteins. Full-length human MEK-1 is generated by PCR and purified as a fusion protein from Escherichia coli lysates. Sorafenib tosylate is added to a mixture of Raf-1 (80 ng), or B-Raf (80 ng) with MEK-1 (1 μg) in assay buffer [20 mM Tris (pH 8.2), 100 mM NaCl, 5 mM MgCl2, and 0.15% β-mercaptoethanol] at a final concentration of 1% DMSO. The Raf kinase assay (final volume of 50 μL) is initiated by adding 25 μL of 10 μM γ[33P]ATP (400 Ci/mol) and incubated at 32 °C for 25 minutes. Phosphorylated MEK-1 is harvested by filtration onto a phosphocellulose mat, and 1% phosphoric acid is used to wash away unbound radioactivity. After drying by microwave heating, a β-plate counter is used to quantify filter-bound radioactivity. Human VEGFR2 (KDR) kinase domain is expressed and purified from Sf9 lysates. Time-resolved fluorescence energy transfer assays for VEGFR2 are performed in 96-well opaque plates in the time-resolved fluorescence energy transfer format. Final reaction conditions are as follows: 1 to 10 μM ATP, 25 nM poly GT-biotin, 2 nM Europium-labeled phospho (p)-Tyr antibody (PY20), 10 nM APC, 1 to 7 nM cytoplasmic kinase domain in final concentrations of 1% DMSO, 50 mM HEPES (pH 7.5), 10 mM MgCl2, 0.1 mM EDTA, 0.015% Brij-35, 0.1 mg/mL BSA, and 0.1% β-mercaptoethanol. Reaction volumes are 100 μL and are initiated by addition of enzyme. Plates are read at both 615 and 665 nM on a Perkin-Elmer VictorV Multilabel counter at ~1.5 to 2.0 hours after reaction initiation. Signal is calculated as a ratio: (665 nm/615 nM) × 10,000 for each well. For IC50 generation, Sorafenib tosylate is added before the enzyme initiation. A 50-fold stock plate is made with Sorafenib tosylate serially diluted 1:3 in a 50% DMSO/50% distilled water solution. Final Sorafenib tosylate concentrations range from 10 μM to 4.56 nM in 1% DMSO.
Cell Research:

[1]

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  • Cell lines: MDA-MB-231, and HAoSMC
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 72 hours
  • Method:

    Cells are exposed to increasing concentrations of Sorafenib tosylate for 72 hours. Cell number is quantitated using the Cell TiterGlo ATP Luminescent assay kit. This assay measures the number of viable cells per well by measurement of luminescent signal based on amount of cellular ATP.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Female NCr-nu/nu mice implanted s.c. with MDA-MB-231, Colo-205, HT-29, H460, or A549 cells
  • Dosages: ~60 mg/kg
  • Administration: Orally once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 63 mg/mL warmed (135.53 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5%DMSO+45%PEG400+50%H2O
For best results, use promptly after mixing.
0.375mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 464.82
Formula

C21H16ClF3N4O3

CAS No. 284461-73-0
Storage powder
in solvent
Synonyms NSC-724772
Smiles CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04710641 Not yet recruiting Drug: MTL-CEBPA|Drug: Sorafenib Hepatocellular Carcinoma|Hepatitis B|Hepatitis C Mina Alpha Limited May 1 2021 Phase 2
NCT02867280 Terminated Drug: Sorafenib Hepatocellular Carcinoma|Recurrence Sun Yat-sen University June 1 2016 Phase 3
NCT02530476 Completed Drug: Selinexor|Drug: Sorafenib Leukemia|Acute Myeloid Leukemia M.D. Anderson Cancer Center|Karyopharm Therapeutics Inc|National Cancer Institute (NCI) December 8 2015 Phase 1|Phase 2
NCT02636426 Completed Drug: sorafenib Neoplasms VU University Medical Center September 2015 Phase 1
NCT02599337 Completed Drug: Nexavar|Drug: Sorafenib Fasting Yabao Pharmaceutical Group July 2015 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Raf Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID