Sorafenib (BAY 43-9006)

Catalog No.S7397 Synonyms: NSC-724772

For research use only.

Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.

Sorafenib (BAY 43-9006) Chemical Structure

CAS No. 284461-73-0

Selleck's Sorafenib (BAY 43-9006) has been cited by 414 publications

Purity & Quality Control

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Biological Activity

Description Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
Targets
Raf-1 [1]
(Cell-free assay)
mVEGFR2(Flk1) [1]
(Cell-free assay)
mVEGFR3 [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
B-Raf (V599E) [1]
(Cell-free assay)
Click to View More Targets
6 nM 15 nM 20 nM 22 nM 38 nM
In vitro

Sorafenib inhibits both wild-type and V599E mutant B-Raf activity with IC50 of 22 nM and 38 nM, respectively. Sorafenib also potently inhibits mVEGFR2 (Flk-1), mVEGFR3, mPDGFRβ, Flt3, and c-Kit with IC50 of 15 nM, 20 nM, 57 nM, 58 nM, and 68 nM, respectively. Sorafenib weakly inhibits FGFR-1 with IC50 of 580 nM. Sorafenib tosylate is not active against ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-Met, PKB, PKA, cdk1/cyclinB, PKCα, PKCγ, and pim-1. Sorafenib markedly inhibits VEGFR2 phosphorylation in NIH 3T3 cells with IC50 of 30 nM, and Flt-3 phosphorylation in HEK-293 cells with IC50 of 20 nM. Sorafenib potently blocks MEK 1/2 and ERK 1/2 phosphorylation in most cell lines but not in A549 or H460 cells, while having no effect on inhibition of the PKB pathway. Sorafenib inhibits the proliferation of HAoSMC and MDA-MB-231 cells with IC50 of 0.28 μM and 2.6 μM, respectively. [1] In addition to inhibition of the RAF/MEK/ERK signaling pathway, Sorafenib significantly inhibits the phosphorylation of eIF4E and down-regulates Mcl-1 levels in hepatocellular carcinoma (HCC) cells in a MEK/ERK-independent manner. Sorafenib inhibits the proliferation of PLC/PRF/5 and HepG2 cells with IC50 of 6.3 μM and 4.5 μM, respectively, and leads to the significant induction of apoptosis. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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rhabdomyosarcoma MV7BcpRqfmm{YXygZYN1cX[rdImgZZN{[Xl? NXnyZ2R3TUN3MDC9JFEvPSEQvF2= M1fRfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Mki4NVg3Lz5{N{K4PFE5PjxxYU6=
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HL-60(TB) MlnaR5l1d3SxeHnjbZR6KGG|c3H5 MnvqS2k2OCB;IEGuOVgh|ryP NIf1R209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
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HCT116 M{ixemN6fG:2b4jpZ4l1gSCjc4PhfS=> MoTVS2k2OCB;IEGuOVgh|ryP MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
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HCT116 NFvp[JRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2m3UGdKPTBiPTCxMlU5KM7:TR?= NV24VWk1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
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OVCAR3 NH74cnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIKxOVFIUTVyIE2gN{4yPiEQvF2= NYfBUWd4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
OVCAR4 M2W5O2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFnTWWZIUTVyIE2gN{4yPiEQvF2= NVn5fYRjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
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SNB19 MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYP0N3UxT0l3MDC9JFMvOTZizszN Mmj1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
OVCAR5 NXy3OGNlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M33yS2dKPTBiPTCzMlE3KM7:TR?= NXXqcYhGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
DU145 NGXwZWJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUnHTVUxKD1iMz6xOkDPxE1? NUDaPIZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
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MDA-MB-231 MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGGySJhVT0liPTCzMlE3KM7:TR?= NYjKPZZbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
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BT549 MlLmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWrHTVUxKD1iMz6xOkDPxE1? NEG1SVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
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OVCAR5 MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M164e2dKPTBiPTCzMlE3KM7:TR?= M13iRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
RXF393 M3f6UWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NVHZbYVJT0l3MDC9JFMvOTZizszN NVLxUZR2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SNB75 NVfhVmJ{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M{P0eGdKPTBiPTCzMlE3KM7:TR?= NEnybWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
OVCAR3 M4DYc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NV;oUFF[T0l3MDC9JFMvOTZizszN NWXibHN4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SNB19 M4HOcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MYrHTVUxKD1iMz6xOkDPxE1? M17rVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
SK-MEL-5 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MoDXWGdKKD1iMz6xOkDPxE1? NYDhUWR1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
OVCAR4 NYryWFh1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MWDHTVUxKD1iMz6xOkDPxE1? NE[2[W49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SK-MEL-2 NYHWdo5kSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NFf6ZZBVT0liPTCzMlE3KM7:TR?= NEO3dpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
BT549 M2\4U2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MVXHTVUxKD1iMz6xOkDPxE1? NXHsSGxxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
MOLT4 M4PkXmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NHnnSHlIUTVyIE2gN{4yPiEQvF2= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
K562 M4jmNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MnzQS2k2OCB;IEOuNVYh|ryP MoTRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
HCC2998 NW[zSlg3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M3zjdmdKPTBiPTCzMlE3KM7:TR?= NIfOd2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
HCC2998 MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Mo[zWGdKKD1iMz6xOkDPxE1? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
A549/ATCC NG\oWXFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M3jmUWdKPTBiPTCzMlE3KM7:TR?= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
DU145 NWX0fZFLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MmT6S2k2OCB;IEOuNVYh|ryP NILCb249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SR MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NH3wVIxIUTVyIE2gN{4yPiEQvF2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
MCF7 NVjSOZlsS3m2b4TvfIlkcXS7IHHzd4F6 M{DncmlEPTBiPTCzMlE5KM7:TR?= M3PKXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUK3PFAyLz5{OEmyO|gxOTxxYU6=
PC3 NGD5SpFEgXSxdH;4bYNqfHliYYPzZZk> M{XtbmlEPTBiPTCzMlE5KM7:TR?= M4TTc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUK3PFAyLz5{OEmyO|gxOTxxYU6=
MCF7 NIrKU4REgXSxdH;4bYNqfHliYYPzZZk> NY\vXYlMUUN3MDC9JFMvOThizszN NFnEWlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e3O|AxQSd-Mke3O|cxODl:L3G+
A549 NGrWOWtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MlXuTWM2OCB;IEOuNVkh|ryP NG\FbJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe3PFk6PSd-MkW3O|g6QTV:L3G+
PC3 NVHZcHVFS3m2b4TvfIlkcXS7IHHzd4F6 NYTHVVFqUUN3MDC9JFMvOjRizszN MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd5N{CwPUc,Ojd5N{ewNFk9N2F-
HeLa NIjUfFBHfW6ldHnvckBie3OjeR?= M17YRmlEPTBiPTCzMlMh|ryP M1mzflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MkK1O|A3Lz5zNUKyOVcxPjxxYU6=
HeLa NY[zWFhJTnWwY4Tpc44h[XO|YYm= MVPJR|UxKD1iMz6zJO69VQ>? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTJ{NUewOkc,OTV{MkW3NFY9N2F-
LoVo MVHDfZRwfG:6aXPpeJkh[XO|YYm= MULJR|UxKD1iMz6zJO69VQ>? M4G4UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEW0NFE4Lz5{M{S1OFAyPzxxYU6=
A375 MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MlLuTWM2OCB;IEOuN|Yh|ryP M4rQS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkCyOlc1Lz5{OU[wNlY4PDxxYU6=
HT-29 Ml;1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MVfJR|UxKD1iMz6zO{DPxE1? M1LsS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUmxPVM5Lz5{Nkm5NVk{QDxxYU6=
FLT3 gene-deficient U937 MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MYjHTVUxKD1iMz60JO69VQ>? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdyOES2PEc,OjF5MEi0Olg9N2F-
FLT3 negative U937 MYjDfZRwfG:6aXPpeJkh[XO|YYm= NUDCWGVYT0l3MDC9JFMvPCEQvF2= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzOEewPUc,OjN4MUi3NFk9N2F-
U937 M3O5N2N6fG:2b4jpZ4l1gSCjc4PhfS=> MmG0S2k2OCB;IEOuOEDPxE1? M2e4O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEixNFI{Lz5{NkC4NVAzOzxxYU6=
A375P NUfv[FhJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MX\HTVUxKD1iMz60JO69VQ>? MoTtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2NUmxOFQoRjJ7NEW5NVQ1RC:jPh?=
ACHN M4e3PGN6fG:2b4jpZ4l1gSCjc4PhfS=> NXzXbXpDUUN3MDC9JFMvPCEQvF2= MkD1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3MUe5NFgoRjJ7NUG3PVA5RC:jPh?=
ACHN NF36RnNEgXSxdH;4bYNqfHliYYPzZZk> M2PLcWlEPTBiPTCzMlQh|ryP MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ7N{[4PEc,Ojl{OUe2PFg9N2F-
HepG2 M{XGZWZ2dmO2aX;uJIF{e2G7 M1vDWmlEPTBiPTCzMlQh|ryP NWXhOZZ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wO|E5PjFpPkK2NFcyQDZzPD;hQi=>
A375P NVTieVhXS3m2b4TvfIlkcXS7IHHzd4F6 MVrHTVUxKD1iMz60JO69VQ>? MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh5OEG5N{c,OjR6N{ixPVM9N2F-
HepG2 M{XNUmN6fG:2b4jpZ4l1gSCjc4PhfS=> M330O2lEPTBiPTCzMlQ1KM7:TR?= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{N{iwNUc,Ojh7Mke4NFE9N2F-
HepG2 NYrU[JJGS3m2b4TvfIlkcXS7IHHzd4F6 M{TLRmlEPTBiPTCzMlQ1KM7:TR?= NVvBWWNnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3O|cxODlpPkK3O|c4ODB7PD;hQi=>
ACHN M2n0eWN6fG:2b4jpZ4l1gSCjc4PhfS=> NH23S41KSzVyIE2gN{42KM7:TR?= MkHaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl5OE[0N|YoRjJ7N{i2OFM3RC:jPh?=
HepG2 MoD3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MlXPTWM2OCB;IEOuOUDPxE1? NE\xXZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS2NlI3PSd-MkW0OlIzPjV:L3G+
HT-29 NIDmbXBEgXSxdH;4bYNqfHliYYPzZZk> Ml;1TWM2OCB;IEOuOlEh|ryP M3jzWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEK2PFE2Lz5{NEiyOlgyPTxxYU6=
HT-29 MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MoPOTWM2OCB;IEOuOlEh|ryP MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJzNki0PUc,OzB{MU[4OFk9N2F-
HT-29 MUTDfZRwfG:6aXPpeJkh[XO|YYm= M1rBZ2lEPTBiPTCzMlYyKM7:TR?= NUjI[JpqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPFYzOzhpPkK1NFg3OjN6PD;hQi=>
HT-29 NWrGR|A1S3m2b4TvfIlkcXS7IHHzd4F6 M37SSGlEPTBiPTCzMlYyKM7:TR?= NYKwUJd5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0OFA5PzlpPkK1OFQxQDd7PD;hQi=>
MCF7 MVfBcpRq[2GwY3XyJIFkfGm4aYT5JIF{e2G7 MV\JR|UxKD1iMz62OEDPxE1? MnvvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NEm4OFEoRjJ7NUS5PFQyRC:jPh?=
Sf9 MmXlSpVv[3Srb36gZZN{[Xl? NYrNSpdnUUN3MDC9JFMvQCEQvF2= M2roVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{C4OFY5Lz5{MUewPFQ3QDxxYU6=
Sf9 M17XcWZ2dmO2aX;uJIF{e2G7 M4DybmlEPTBiPTCzMlgh|ryP NIqwOG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xPFcxQSd-MkO2NVg4ODl:L3G+
Sf9 NV7ZbpZqTnWwY4Tpc44h[XO|YYm= MWPJR|UxKD1iMz64JO69VQ>? NHTmfY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC4NVAzOyd-Mk[wPFExOjN:L3G+
A2058 MmPOR5l1d3SxeHnjbZR6KGG|c3H5 MmPPTWM2OCB;IEOuPEDPxE1? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjdyOEm4O{c,OjJ5MEi5PFc9N2F-
NCI-H460 M3yyTWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXKyUGV3UUN3MDC9JFMvQSEQvF2= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR3NECxO{c,OjN2NUSwNVc9N2F-
SK-MEL-30 NEiwb|NEgXSxdH;4bYNqfHliYYPzZZk> MXjJR|UxKD1iMz65JO69VQ>? NHfG[I49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS2NVgzPyd-Mkm0OlE5Ojd:L3G+
HT-29 M2q0cGFvfGmlYX7j[ZIh[WO2aY\peJkh[XO|YYm= NYTWRpJVUUN3MDC9JFMvQTdizszN MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2OUi0NUc,Ojl3NEm4OFE9N2F-
SF268 NUHrc4xpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYDUS2khRSB|Lkm4JO69VQ>? NWrwSJJJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
SNB75 NWDiUoJkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn7zWGdKKD1iMz65PEDPxE1? M1TFbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
OVCAR3 MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH3NOJRVT0liPTCzMlk5KM7:TR?= NYLWVJJXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
SNB19 NX[yTnlDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGOyVlVVT0liPTCzMlk5KM7:TR?= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
Hs 578T Mn\OS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXrNTlhqXEeLIE2gN{46QCEQvF2= MlmxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
TK10 MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnLQS2k2OCB;IEOuPVgh|ryP MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
BT549 MlLFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWTUS2khRSB|Lkm4JO69VQ>? NWiwXYUxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
Caki1 Mm\iRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M3vTb3RIUSB;IEOuPVgh|ryP M2jubVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
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HOP92 NG\YZYVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NXfxS2ZQXEeLIE2gOU4xOSEQvF2= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
BT549 NX;xOpN4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NETvfpZVT0liPTC1MlAyKM7:TR?= NG[zVlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
MDA-MB-231 MW\DfZRwfG:6aXPpeJkh[XO|YYm= MX\JR|UxKD1iNT6xJO69VQ>? NGfIWW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkG1PVQ5Oyd-Mk[xOVk1QDN:L3G+
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A549 M{jrfmN6fG:2b4jpZ4l1gSCjc4PhfS=> MkPTTWM2OCB;IEWuNlEh|ryP NUHyNWtIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxPFE1OTRpPkKwNVgyPDF2PD;hQi=>
HeLa M4PMd2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHy0NIhKSzVyIE2gOU4zOyEQvF2= MlrCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|NEK4OlcoRjJ4M{SyPFY4RC:jPh?=
786-O NH7IN2REgXSxdH;4bYNqfHliYYPzZZk> NEC0dndKSzVyIE2gOU4{KM7:TR?= NXvG[4huRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3PFY1OzZpPkK5O|g3PDN4PD;hQi=>
HCT116 NYHZRY1kSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NEH4S45IUTVyIE2gOU41KM7:TR?= M4Hme|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MkK1O|A3Lz5zNUKyOVcxPjxxYU6=
A375 NEfne|BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MUHJR|UxKD1iNT60JO69VQ>? MnfmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2N{e1NFUoRjF6NEe3OVA2RC:jPh?=
SK-MEL-188 M2f3[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NHjDXWhKSzVyIE2gOU41KM7:TR?= NYj0UnVrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OlE{QTJpPkG3OVYyOzl{PD;hQi=>
A375 MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MVHJR|UxKD1iNT60JO69VQ>? M2LBblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEW2OVQ5Lz5{MEC1OlU1QDxxYU6=
MCF7 M17hc2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVSxcJhXUUN3MDC9JFUvPSEQvF2= MlPRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzNUm0PFMoRjJ4MUW5OFg{RC:jPh?=
A375 NVnGdIhXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NXLkZppVUUN3MDC9JFUvPThizszN MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR4NEi4O{c,OTl2NkS4PFc9N2F-
A375P Mm[1R5l1d3SxeHnjbZR6KGG|c3H5 MVHJR|UxKD1iNT61PEDPxE1? M{fyR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyN{m3PFU5Lz5{MEe5O|g2QDxxYU6=
A375P NEPzUY5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NXe5U3JST0l3MDC9JFUvPThizszN MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN3M{W3NUc,OjF|NUO1O|E9N2F-
A375P NX3rfFZkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXLhPVB3T0l3MDC9JFUvPThizszN MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjBzNEe1OUc,OjJyMUS3OVU9N2F-
A375P NVHZOGZTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVXLVJJ1T0l3MDC9JFUvPThizszN MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2OU[1PEc,OjBzNEm2OVg9N2F-
A375P NEfMNohCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NVTyZYRFT0l3MDC9JFUvPThizszN NXrFVph6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0OlY2PDJpPkKwOFY3PTR{PD;hQi=>
A375P M{juVWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MlvyTWM2OCB;IEWuOkDPxE1? NVTJNI1RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4OVc6PjNpPkG5PFU4QTZ|PD;hQi=>
A375P NVvSVXA4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Mnr4TWM2OCB;IEWuOkDPxE1? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV7Mk[yPEc,OjF3OUK2Nlg9N2F-
A375P NUjGSVVWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M2q2VWlEPTBiPTC1MlYh|ryP NE\GWYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCzN|A3Oyd-MkKwN|MxPjN:L3G+
A375P NYLDcGp5S3m2b4TvfIlkcXS7IHHzd4F6 MlvTTWM2OCB;IEWuOkDPxE1? NET4e2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUi5O|M3Pid-MUm4PVc{PjZ:L3G+
A375P NXXpb5JxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Mmm1TWM2OCB;IEWuOkDPxE1? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ2N{eyNEc,OjJ4NEe3NlA9N2F-
HCT116 MYXDfZRwfG:6aXPpeJkh[XO|YYm= M1LuNmlEPTBiPTC1MlY2KM7:TR?= NHLMdmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKxOVgyQCd-MkSyNVU5OTh:L3G+
SH-SY5Y MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NEezTVNKSzVyIE2gOU44OyEQvF2= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDNzNUG5Nkc,OjR|MUWxPVI9N2F-
HepG2 NHfhV3NEgXSxdH;4bYNqfHliYYPzZZk> M3\PSmlEPTBiPTC1Mlc1KM7:TR?= NIrTeHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS2NVMyQCd-MkW0OlE{OTh:L3G+
Bel7402 M1njb2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYHJR|UxKD1iNT64JO69VQ>? NGC0T5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S1OFAyPyd-MkO0OVQxOTd:L3G+
HT-29 NGCzPIVEgXSxdH;4bYNqfHliYYPzZZk> MorPTWM2OCB;IEWuPUDPxE1? NGnzcHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEi2OVI4Pid-Mki4OlUzPzZ:L3G+
melanoma NXT0V4ZbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXi1VmxUUUN3MDC9JFYvOSEQvF2= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjN7MkiyOkc,OTZ|OUK4NlY9N2F-
K562 NGLsR29CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MWjHTVUxKD1iNj6yJO69VQ>? MlHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5MEi0OlgoRjJzN{C4OFY5RC:jPh?=
HepG2 M1;GcmN6fG:2b4jpZ4l1gSCjc4PhfS=> NXfMe4wyUUN3MDC9JFYvOiEQvF2= NEPNT|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEi2OVI4Pid-Mki4OlUzPzZ:L3G+
A549 NEflbFFCdnSrY3HuZ4VzKGGldHn2bZR6KGG|c3H5 M4e0T2lEPTBiPTC2MlIyKM7:TR?= NHHJc3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW0PVg1OSd-Mkm1OFk5PDF:L3G+
SMMC7721 M4rCS2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NIDnS4ZKSzVyIE2gOk4zOyEQvF2= NVXXb|NmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3NlE6OjRpPkKyO|IyQTJ2PD;hQi=>
HepG2 Mnj5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NFTqO5pKSzVyIE2gOk4{KM7:TR?= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl|MkC3NUc,OjN7M{KwO|E9N2F-
SF295 M2OwbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1L5d3RIUSB;IE[uN|Eh|ryP NXXTTVNjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
SK-MEL-2 MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlTkWGdKKD1iNj6zNUDPxE1? NXi0d4RORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
OVCAR5 NVzMNpBmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVPQbXZuXEeLIE2gOk4{OSEQvF2= MmTRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
UO31 NW\uZlZMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIPZTWRVT0liPTC2MlMyKM7:TR?= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
A498 MnPkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NVz6TZBLXEeLIE2gOk4{OSEQvF2= NH;lZZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
MALME-3M M2fhfGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MnPFWGdKKD1iNj6zNUDPxE1? M33SNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
U251 M1PsNmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NFzvTZhVT0liPTC2MlMyKM7:TR?= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
SK-MEL-2 NVe4dW9SSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MX;MR|UxKD1iNj6zNUDPxE1? M1zlUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
RPMI8226 NX7JPYR6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MkDJWGdKKD1iNj6zNUDPxE1? MnjpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
HCC2998 NGXp[YNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MV\MR|UxKD1iNj6zNUDPxE1? NWjNSoExRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
NCI-H522 NHXp[o5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NELUbnRVT0liPTC2MlMyKM7:TR?= M4TKXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
HUVEC NVTZVYY3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NHfucIRKSzVyIE2gOk41OiEQvF2= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEKxPUc,OjN4NESyNVk9N2F-
A549 NEDqZpJEgXSxdH;4bYNqfHliYYPzZZk> NXfrPVdnUUN3MDC9JFYvPTNizszN MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB2M{K2PEc,OjdyNEOyOlg9N2F-
A549 NX\nWmJvS3m2b4TvfIlkcXS7IHHzd4F6 NWTXOmZtUUN3MDC9JFYvPTNizszN Mn;KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|NEC5NVMoRjJ6M{SwPVE{RC:jPh?=
LoVo NHLNcINCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NEC4fG1KSzVyIE2gOk42PiEQvF2= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDNzNUG5Nkc,OjR|MUWxPVI9N2F-
A375 NYTtZnJ3TnWwY4Tpc44h[XO|YYm= MVnJR|UxKD1iNj61PVkh|ryP MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOThyN{WwO{c,OjF6MEe1NFc9N2F-
HCT116 M3PoXmZ2dmO2aX;uJIF{e2G7 NHTTPJhIUTVyIE2gOk43KM7:TR?= M4j3N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MkK1O|A3Lz5zNUKyOVcxPjxxYU6=
HepG2 NF\p[ldEgXSxdH;4bYNqfHliYYPzZZk> MX3JR|UxKD1iNj63JO69VQ>? M1LHdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUW5OFg{Lz5{NkG1PVQ5OzxxYU6=
BCPAP M2fHOWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NETRTVVKSzVyIE2gOk44KM7:TR?= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTB|MkCzNUc,OjlyM{KwN|E9N2F-
A549 NGjJeHhEgXSxdH;4bYNqfHliYYPzZZk> MULJR|UxKD1iNj63JO69VQ>? M4HqfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OE[1Nlc3Lz5{OEi2OVI4PjxxYU6=
PC3 M4jtVmN6fG:2b4jpZ4l1gSCjc4PhfS=> NI\jNWZKSzVyIE2gOk45KM7:TR?= MkHvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMkG5OlcoRjJ|MEKxPVY4RC:jPh?=
SGC7901 NGT0NolEgXSxdH;4bYNqfHliYYPzZZk> M1HuZmlEPTBiPTC2Mlkh|ryP M3HlXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEW0NFE4Lz5{M{S1OFAyPzxxYU6=
OS-RC2 MXvDfZRwfG:6aXPpeJkh[XO|YYm= NVu5PZFHUUN3MDC9JFch|ryP MlTyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3MUe5NFgoRjJ7NUG3PVA5RC:jPh?=
OS-RC2 MXrDfZRwfG:6aXPpeJkh[XO|YYm= M3f6U2lEPTBiPTC3JO69VQ>? NVPjbo1qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyPVc3QDhpPkK5Nlk4Pjh6PD;hQi=>
COLO205 NH3RVGJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBpfW2jbh?= NWiwSmRLUUN3MDC9JFcvODRizszN NEXxWYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK0NlU2Oyd-MkiyOFI2PTN:L3G+
rhabdomyosarcoma NFfiNJVEgXSxdH;4bYNqfHliYXP0bZZqfHliYXfhbY5{fCCqdX3hci=> M37wfmNEPTBiPTC3MlA2KM7:TR?= M3XmXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Mki4NVg3Lz5{N{K4PFE5PjxxYU6=
HuH7 NIG1S45EgXSxdH;4bYNqfHliYYPzZZk> NXPxR241UUN3MDC9JFcvOSEQvF2= NXPZfI1vRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xOVk1QDNpPkK2NVU6PDh|PD;hQi=>
MDA-MB-231 NHrobY9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NIPxdpFKSzVyIE2gO{4yQCEQvF2= M3TwSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{KxPVI1Lz5{MkeyNVkzPDxxYU6=
FLT3-negative K562 MYrDfZRwfG:6aXPpeJkh[XO|YYm= NWLZWJp{T0l3MDC9JFcvOyEQvF2= Mn7QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUi3NFkoRjJ|NkG4O|A6RC:jPh?=
K562 NVTpNplvTnWwY4Tpc44h[XO|YYm= MWHHTVUxKD1iNz6zJO69VQ>? NILrdmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC4NVAzOyd-Mk[wPFExOjN:L3G+
K562 NHn5XmRHfW6ldHnvckBie3OjeR?= NYfIfVI5T0l3MDC9JFcvOyEQvF2= MlXOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyOEGwNlMoRjJ4MEixNFI{RC:jPh?=
MCF7 NUXw[otLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MnjpTWM2OCB;IEeuN|Mh|ryP MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEKxPUc,OjN4NESyNVk9N2F-
A549 Mmf5R5l1d3SxeHnjbZR6KGG|c3H5 MlXWWGdKKD1iNz6zOkDPxE1? Moe3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
WI38 MV3DfZRwfG:6aXPpeJkh[XO|YYm= M{LXZmlEPTBiPTC3MlU1KM7:TR?= NXntXpNWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NlY5OTVpPkK0PFI3QDF3PD;hQi=>
A375 MXPDfZRwfG:6aXPpeJkh[XO|YYm= M2Hu[2lEPTBiPTC3MlU3KM7:TR?= NVGyWpRSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVU5OThpPkK0NlE2QDF6PD;hQi=>
MDA-MB-231 Mmn1R5l1d3SxeHnjbZR6KGG|c3H5 NEHTTHNKSzVyIE2gO{43OiEQvF2= MkC1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzOEG0NVQoRjJyMUixOFE1RC:jPh?=
786-0 NVvmU4VLS3m2b4TvfIlkcXS7IHHzd4F6 NWG2SIh{XEeLIE2gO{43OiEQvF2= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
HS27 MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NXPFTm16UUN3MDC9JFcvQCEQvF2= NVWwWpp6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4OVc6PjNpPkG5PFU4QTZ|PD;hQi=>
HS27 MV3DfZRwfG:6aXPpeJkh[XO|YYm= NXvZZnp{UUN3MDC9JFcvQCEQvF2= MofkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6OUezOlYoRjF7OEm3N|Y3RC:jPh?=
HCT116 MY\DfZRwfG:6aXPpeJkh[XO|YYm= NEnjcZhKSzVyIE2gO{45KM7:TR?= NEjVSGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4N|U6Oid-MkK0PFM2QTJ:L3G+
HS27 MlLHRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? Ml7uTWM2OCB;IEeuPFUh|ryP NYe1[4FSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0OlQ5QDdpPkG5OFY1QDh5PD;hQi=>
HS27 MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MX3HTVUxKD1iNz64OUDPxE1? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN3M{W3NUc,OjF|NUO1O|E9N2F-
A549/ATCC NIrLO|VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{XyUXRIUSB;IEeuPVQh|ryP NVzFUYJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
DU145 NWTKem11T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEPOZ|lVT0liPTC3Mlk1KM7:TR?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
NCI/ADR-RES NYjoPHQ2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV;US2khRSB5Lkm0JO69VQ>? M{XpelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
MCF7 NYTmVHZJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlrhWGdKKD1iNz65OEDPxE1? MkTBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
PC3 NViwXVIzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NWrZd5VkXEeLIE2gO{46PCEQvF2= NIrEe4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
UO31 MnO1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M3myWnRIUSB;IEeuPVQh|ryP M2LqfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
NCI-ADR-RES NFGxRmFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NXv3W2h{XEeLIE2gO{46PCEQvF2= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
LOXIMVI NFHhZldCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmDEUGM2OCB;IEeuPVQh|ryP NWPWRVVNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SK-MEL-28 NXHXNWZtSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NVvJdWRWXEeLIE2gO{46PCEQvF2= NFq3O5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
KM12 NWLseFBmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MmTJWGdKKD1iNz65OEDPxE1? M2X6dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
COLO205 MorWRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MV7US2khRSB5Lkm0JO69VQ>? MoqyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
HT-29 NHi5c29CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MVXUS2khRSB5Lkm0JO69VQ>? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
NCI-H226 NIXpOJJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MnzpWGdKKD1iNz65OEDPxE1? MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
HOP62 MoPIRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NGSyUldVT0liPTC3Mlk1KM7:TR?= M3S2ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
T47D NHruPFFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NGTsOJFVT0liPTC3Mlk1KM7:TR?= MoXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
MDA-MB-468 NUDh[XVNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MlTQWGdKKD1iNz65OEDPxE1? NVfUUYtbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
EKVX MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NX;FO4psXEeLIE2gO{46PCEQvF2= NX;KSoxHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
MCF7 MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NYC1XoFtXEeLIE2gO{46PCEQvF2= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
Hs 578T NF\2WGNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MUjUS2khRSB5Lkm0JO69VQ>? NYLzZpluRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
MGC803 M2noUWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NYLqNGdUUUN3MDC9JFcvQTlizszN NXX2dnBURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1OlAxPDlpPkK2OVYxODR7PD;hQi=>
HCT116 MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NHroWoRKSzVyIE2gPE4xQCEQvF2= MlfsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2NEC0O|koRjJ2NESwOFc6RC:jPh?=
PC3 MXXDfZRwfG:6aXPpeJkh[XO|YYm= NFTTRlZKSzVyIE2gPE4xQCEQvF2= MnrzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyNEOyOlgoRjJ5MESzNlY5RC:jPh?=
HCT116 MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NHrRNYlKSzVyIE2gPE4xQCEQvF2= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEKxPUc,OjN4NESyNVk9N2F-
WM266.4 M3L6OmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MW\HTVUxKD1iOD6xJO69VQ>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB{NUm5Okc,OjNyMkW5PVY9N2F-
WM266.4 MkfGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NGXKRWRIUTVyIE2gPE4yOiEQvF2= Mnf2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3OEO2OlkoRjJ{NUizOlY6RC:jPh?=
Ketr3 NH3mXZZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NVXkS3NyUUN3MDC9JFgvOjdizszN Mn3VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MU[4OFkoRjNyMkG2PFQ6RC:jPh?=
A375 MkPKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M3HqRWlEPTBiPTC4MlI4KM7:TR?= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJzNki0PUc,OzB{MU[4OFk9N2F-
HepG2 NWXsO5FwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M120U2lEPTBiPTC4MlI4KM7:TR?= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJzNki0PUc,OzB{MU[4OFk9N2F-
MX1 M1rHZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NH7icXJKSzVyIE2gPE4zPyEQvF2= NEHlXXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKxOlg1QSd-M{CyNVY5PDl:L3G+
MX1 NHSwR4xEgXSxdH;4bYNqfHliYYPzZZk> MmniTWM2OCB;IEiuNlch|ryP NYTLbWxrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2O|UyOzVpPkK0Olc2OTN3PD;hQi=>
WM266.4 MmfFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoXXS2k2OCB;IEiuN{DPxE1? NHzrUpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkO2NVY5Pid-MkKzOlE3QDZ:L3G+
PLC/PRF/5 MoLHR5l1d3SxeHnjbZR6KGG|c3H5 NVLIWnFwUUN3MDC9JFgvOyEQvF2= Mof2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3M{GwOVMoRjJzNUOxNFU{RC:jPh?=
A375 MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NHjMdGlKSzVyIE2gPE4{OyEQvF2= M3fwdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OEi2N|I1Lz5{OUi4OlMzPDxxYU6=
HCT116 MXrDfZRwfG:6aXPpeJkh[XO|YYm= NWnjcG45UUN3MDC9JFgvPDFizszN NWT2VpM6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2N|E4QDhpPkK5OlMyPzh6PD;hQi=>
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HepG2 MonCR5l1d3SxeHnjbZR6KGG|c3H5 NF;heWZKSzVyIE2gPE41OiEQvF2= NHjXTWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i3NVkxQSd-MkO4O|E6ODl:L3G+
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Hep3B M2XwTWN6fG:2b4jpZ4l1gSCjc4PhfS=> NV;vdZU6UUN3MDC9JFkvPCEQvF2= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh4NUK3Okc,Ojh6NkWyO|Y9N2F-
LoVo NGrXbGFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmfzTWM2OCB;IEmuOFch|ryP MoWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzMEKxO|UoRjJ7MUCyNVc2RC:jPh?=
SMMC7721 NU\wepFTSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MlS0TWM2OCB;IEmuPVYh|ryP MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ|N{GyN{c,OjV4M{exNlM9N2F-
MCF7 NFTwfFdEgXSxdH;4bYNqfHliYYPzZZk> MWTUS2khRSB7Lkm3JO69VQ>? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
IGROV1 MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkGyWGdKKD1iMUCg{txO NV[xb41pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
ACHN NYLYZlB[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3PuN3RIUSB;IEGwJO69VQ>? NEX2XZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
TK10 NXTqb5hiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV3US2khRSBzMDFOwG0> NEDzR4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
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TK10 M4Xnb2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MnnNWGdKKD1iMUCg{txO MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
RXF393 MkXERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NW\mdoJIXEeLIE2gNVAh|ryP M1XrW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
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SF539 M37TZ2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NIPjWlNVT0liPTCxNEDPxE1? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
SF268 MUnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M{jVbXRIUSB;IEGwJO69VQ>? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
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Bel7402 NVS5S5g2S3m2b4TvfIlkcXS7IHHzd4F6 M1G2fWlEPTBiPTCxNE4zPiEQvF2= MonnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3MESyNFQoRjJzNUC0NlA1RC:jPh?=
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OVCAR3 NVrEOZlVS3m2b4TvfIlkcXS7IHHzd4F6 NGLHOJBVT0liPTCxNE4{OiEQvF2= NGCwVWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
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Hep3B Mmj6R5l1d3SxeHnjbZR6KGG|c3H5 NHTOTpFKSzVyIE2gNVEvOiEQvF2= NUnxXFdvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizOFI1ODBpPkK4N|QzPDByPD;hQi=>
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HepG2 NVrLRnFkS3m2b4TvfIlkcXS7IHHzd4F6 M1HicGlEPTBiPTCxNU41QSEQvF2= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTVyNEKwOEc,OjF3MESyNFQ9N2F-
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PANC1 NIrScplEgXSxdH;4bYNqfHliYYPzZZk> M4j1OmlEPTBiPTCxNk4{KM7:TR?= NGX5OGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOwNFkzOCd-MkSzNFA6OjB:L3G+
HepG2 NXnhc5dFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MoH4TWM2OCB;IEGyMlU1KM7:TR?= MmeyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyM{KwN|EoRjJ7MEOyNFMyRC:jPh?=
A549 MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NID2NIFKSzVyIE2gNVIvPTRizszN MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEKxPUc,OjN4NESyNVk9N2F-
Caki1 MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV7lR2ZGXEeLIE2gNVIvPTlizszN NGSyWJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
OVCAR8 M4DiUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHX6OYlVT0liPTCxNk42QSEQvF2= MoroQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
SKOV3 NFTabFNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NWDldm1uXEeLIE2gNVIvPiEQvF2= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
ACHN MmDaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MV;US2khRSBzMj62JO69VQ>? NFHQ[2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
OVCAR3 NHjqN|hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MYXUS2khRSBzMj62JO69VQ>? MnzXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
OVCAR4 MlX2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MV7US2khRSBzMj62JO69VQ>? NVnmR3JRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
HCT15 NHvOdlhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M3rrZXRIUSB;IEGyMlYh|ryP M{\kcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
SW620 M1fqcmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NWfU[3ZPXEeLIE2gNVIvPiEQvF2= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
A549/ATCC M4K1c2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NHXZS|VVT0liPTCxNk43KM7:TR?= NVGzemxvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
MDA-MB-468 MonBR5l1d3SxeHnjbZR6KGG|c3H5 NFXHW4FVT0liPTCxN{4xQSEQvF2= M174eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
SK-MEL-28 M3[5[WN6fG:2b4jpZ4l1gSCjc4PhfS=> M3TvTnRIUSB;IEGzMlM6KM7:TR?= Mke3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
A549 MlvrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? Ml;WTWM2OCB;IEGzMlY1KM7:TR?= NV;xNph3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1OlAxPDlpPkK2OVYxODR7PD;hQi=>
A375 M3\Wd2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIh2dWGw NEXKcYVKSzVyIE2gNVMvPjRizszN MmmxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{NEK1OVMoRjJ6MkSyOVU{RC:jPh?=
A375 MVnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M4rLeGlEPTBiPTCxN{43PCEQvF2= M{naXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NE[yNlY4Lz5{NUS2NlI3PzxxYU6=
K562 NHnVVnBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MonqTWM2OCB;IEGzMlg2KM7:TR?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEKxPUc,OjN4NESyNVk9N2F-
Hep3B NXLQ[I53S3m2b4TvfIlkcXS7IHHzd4F6 M3HuVWlEPTBiPTCxOE4xQCEQvF2= M3n2OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUC0NlA1Lz5{MUWwOFIxPDxxYU6=
T47D MXPDfZRwfG:6aXPpeJkh[XO|YYm= NHS2cldVT0liPTCxOE4{QCEQvF2= NHnBZ2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
NCI-H226 NYHUSnlPS3m2b4TvfIlkcXS7IHHzd4F6 NGDYSnNVT0liPTCxOE41OiEQvF2= MlnwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
MDA-MB-231 M1nE[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MV7JR|UxKD1iMUSuOlIh|ryP NX3vSWJERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0OFA1PzlpPkK0OFQxPDd7PD;hQi=>
MDA-MB-231 MnXMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NIjjeYRKSzVyIE2gNVQvPjJizszN NWfac|JVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTlpPkKzOlQ1OjF7PD;hQi=>
NCI-H522 M2rae2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1T4NnRIUSB;IEG0MlgzKM7:TR?= Mlu4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
SK-MEL-2 M{eyNmN6fG:2b4jpZ4l1gSCjc4PhfS=> M4LrR3RIUSB;IEG0Mlg2KM7:TR?= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
OS-RC2 NYX1TWo6S3m2b4TvfIlkcXS7IHHzd4F6 MknmTWM2OCB;IEG1JO69VQ>? NIrzeJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUe4OlQ{Pid-Mkm3PFY1OzZ:L3G+
HepG2 NUXEVXo5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NES4RWRKSzVyIE2gNVUh|ryP NYHJZVlDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxNFM5PzNpPkK5NVA{QDd|PD;hQi=>
fibroblast M{XGemFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MV;JR|UxKD1iMUWuNUDPxE1? NED5U4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES3O|UxPSd-MUi0O|c2ODV:L3G+
HT-29 MWfDfZRwfG:6aXPpeJkh[XO|YYm= NGL5T21KSzVyIE2gNVUvOiEQvF2= M{jF[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Nke1NVM2Lz5{NE[3OVE{PTxxYU6=
U87MG M1\BWGN6fG:2b4jpZ4l1gSCjc4PhfS=> MnvCTWM2OCB;IEG1MlU4KM7:TR?= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh{NkixOUc,OjR6Mk[4NVU9N2F-
BT549 NHryPVZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2nxTWxEPTBiPTCxOU45KM7:TR?= M{DH[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
GES-1 MXfDfZRwfG:6aXPpeJkh[XO|YYm= M1T1dmlEPTBiPTCxOU45KM7:TR?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh5MUmwPUc,OjN6N{G5NFk9N2F-
SNB19 MljBRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MXvUS2khRSBzNT64OUDPxE1? NWfJeVd5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
IGROV1 Mn3oRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MWjUS2khRSBzNT65JO69VQ>? NYSwO4ZyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
HCT116 MnjGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NX\Bb5RFVEN3MDC9JFE2NjlizszN NWntUnRnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
OS-RC2 NXLIcIZKS3m2b4TvfIlkcXS7IHHzd4F6 M4LSVWlEPTBiPTCxOkDPxE1? NWHERZV1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OVQxOTdpPkKzOFU1ODF5PD;hQi=>
A375 Mni0R5l1d3SxeHnjbZR6KGG|c3H5 M2X5cWlEPTBiPTCxOk4zPCEQvF2= NYDpUllmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0OlE{OThpPkK1OFYyOzF6PD;hQi=>
SKOV3 NF\GVmREgXSxdH;4bYNqfHliYYPzZZk> MXzUS2khRSBzNj6zOkDPxE1? M1LEd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
WM1361 MnHFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MUDJR|UxKD1iMU[uOFQh|ryP NUDJTXd2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2NFI3PzRpPkK5OlAzPjd2PD;hQi=>
MKN28 NGPnUVBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M1fqXWlEPTBiPTCxO{DPxE1? NF;CSJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUCzNlA{OSd-MkmwN|IxOzF:L3G+
SMMC7721 NX;SNFRzS3m2b4TvfIlkcXS7IHHzd4F6 Mnj5TWM2OCB;IEG3MlMh|ryP M2jzPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUC0NlA1Lz5{MUWwOFIxPDxxYU6=
UACC257 Ml\wR5l1d3SxeHnjbZR6KGG|c3H5 M1fCRXRIUSB;IEG3MlM{KM7:TR?= NF[4ZoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
EAhy926 M{\QT2FvfGmjbnfpc4dmdmmlIHHjeIl3cXS7IHHzd4F6 M2T3UWlEPTBiPTCxPE42OiEQvF2= NX2xbGIzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwN|IxOzFpPkK5NFMzODNzPD;hQi=>
SMMC7721 MoHVR5l1d3SxeHnjbZR6KGG|c3H5 MYHJR|UxKD1iMUiuO{DPxE1? NVTXbItDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNFA6OjBpPkK0N|AxQTJyPD;hQi=>
Ketr3 NWDLb|djS3m2b4TvfIlkcXS7IHHzd4F6 MlTzTWM2OCB;IEG4Mlgh|ryP NVnscVc6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2O|UyOzVpPkK0Olc2OTN3PD;hQi=>
NCI-H522 NIDzc3hEgXSxdH;4bYNqfHliYYPzZZk> M4rUSGlEPTBiPTCxPU4zPiEQvF2= MknYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2NkGzNVgoRjJ3NE[xN|E5RC:jPh?=
A549 NUnEPW82S3m2b4TvfIlkcXS7IHHzd4F6 M3rsVWlEPTBiPTCxPU42PCEQvF2= MnPTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzNkKxNlMoRjJ5MU[yNVI{RC:jPh?=
SH-SY5Y M2DZT2N6fG:2b4jpZ4l1gSCjc4PhfS=> NXn5To1ZUUN3MDC9JFE6NjV2IN88US=> MnnhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6N{G5NFkoRjJ|OEexPVA6RC:jPh?=
MGC803 NFjwb2JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MVXJR|UxKD1iMUmuPVIh|ryP NWHufYt3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxNFM5PzNpPkK5NVA{QDd|PD;hQi=>
EKVX NH7LOoxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWfUS2khRSBzOT65OUDPxE1? Mlj5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
OVCAR5 NUSweFNZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MX7US2khRSB{MDFOwG0> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
UACC62 NY\YenlMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NGrNOHNNSzVyIE2gNlAh|ryP MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
UACC257 M2jVTGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MUjMR|UxKD1iMkCg{txO MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
MDA-MB-231 NHqyZXZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M1ThbGxEPTBiPTCyNEDPxE1? MnLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
U87 Mo\SR5l1d3SxeHnjbZR6KGG|c3H5 MnjrTWM2OCB;IEKxMlA4KM7:TR?= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODR|NUS3PUc,OjB2M{W0O|k9N2F-
EJ NGXqbVREgXSxdH;4bYNqfHliYYPzZZk> MV3JR|UxKD1iMkKuPUDPxE1? MmLXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MEC5NlAoRjJ2M{CwPVIxRC:jPh?=
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PC3 NW\PRmxbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MmfVTWM2OCB;IEK0MlIh|ryP NGC0[Yg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NES0NFQ4QSd-MkS0OFA1Pzl:L3G+
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EAhy926 M{PGOWFvfGlvYX7nbY9o\W6rYzDhZ5Rqfmm2eTDpckBpfW2jbh?= NGq2SJBKSzVyIE2gNlQvOzZizszN M1nOOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUCyNVc2Lz5{OUGwNlE4PTxxYU6=
U251 M1G1NGN6fG:2b4jpZ4l1gSCjc4PhfS=> NE\6T4lKSzVyIE2gNlQvPzFizszN NFrBW209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MESzOVQ4QSd-MkC0N|U1Pzl:L3G+
NIH/3T3 NYKxS|ZXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Mk\tTWM2OCB;IEK0Mlc2KM7:TR?= NVHv[IpMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1PVI3OjhpPkKxOVkzPjJ6PD;hQi=>
NIH/3T3 M1v0dWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M3:0R2lEPTBiPTCyOE44PSEQvF2= Mm\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4NEe3NlAoRjJ{NkS3O|IxRC:jPh?=
DU145 NF;qXY9EgXSxdH;4bYNqfHliYYPzZZk> NYnUXZNEUUN3MDC9JFI1NjlzIN88US=> M4Xo[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MU[yNVI{Lz5{N{G2NlEzOzxxYU6=
DU145 M3rmcmN6fG:2b4jpZ4l1gSCjc4PhfS=> MULJR|UxKD1iMkSuPVEh|ryP MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh5MUmwPUc,OjN6N{G5NFk9N2F-
U251 M2Dh[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MYLMR|UxKD1iMkWuNUDPxE1? M{W0b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
M14 MoCxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MXjMR|UxKD1iMkWuNUDPxE1? NXvvN4plRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
NCI-H522 NGDIVllCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NHjoPINNSzVyIE2gNlUvOSEQvF2= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
OVCAR4 MlvxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYDUS2khRSB{NT6xNkDPxE1? NYD6clAxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
SH-SY5Y NUnk[W5GS3m2b4TvfIlkcXS7IHHzd4F6 Mnv1TWM2OCB;IEK3MlcyKM7:TR?= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF4MkGyN{c,OjdzNkKxNlM9N2F-
A549 NYX2c4dUS3m2b4TvfIlkcXS7IHHzd4F6 M1Tvc2lEPTBiPTCyO{44OSEQvF2= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh5MUmwPUc,OjN6N{G5NFk9N2F-
PLC/PRF/5 MWfDfZRwfG:6aXPpeJkh[XO|YYm= M2f2TWlEPTBiPTCyPU46KM7:TR?= Ml7kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzMEm5OFgoRjJ6MUC5PVQ5RC:jPh?=
SK-MEL-5 M3:5bWN6fG:2b4jpZ4l1gSCjc4PhfS=> NIrPOo5VT0liPTCzNU4zPiEQvF2= MlfqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
A498 M17XR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MXjMR|UxKD1iM{GuOkDPxE1? NHPySHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SK-MEL-28 MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M4L4SGxEPTBiPTCzNU43KM7:TR?= MkPZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
KM12 NEPSeohCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmDYUGM2OCB;IEOxMlYh|ryP MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
COLO205 MUHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MoHDUGM2OCB;IEOxMlYh|ryP NHrRSm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
NCI-H226 MnfLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MWLMR|UxKD1iM{GuOkDPxE1? NHrtSVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SF295 Mk\FRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NWqxe2ZEVEN3MDC9JFMyNjZizszN NVjLeJJJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
HOP62 NWnG[YoySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M4C4R2xEPTBiPTCzNU43KM7:TR?= MljUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
T47D NYjLUoVNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MX;MR|UxKD1iM{GuOkDPxE1? NWr1eZFJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
MHCC97L M2TpO2N6fG:2b4jpZ4l1gSCjc4PhfS=> MV\JR|UxKD1iM{SuOFEh|ryP NV\xfYp6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixNFk6PDhpPkK4NVA6QTR6PD;hQi=>
MDA-MB-231 NF7XVHJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{C0PWlEPTBiPTCzOUDPxE1? MlnhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MUWxPVIoRjJ2M{G1NVkzRC:jPh?=
MDA-MB-231 MYfDfZRwfG:6aXPpeJkh[XO|YYm= MWPJR|UxKD1iM{[g{txO Mor2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2OEO1PVIoRjJ{NEizOVkzRC:jPh?=
B16-BL6 Mn25R5l1d3SxeHnjbZR6KGG|c3H5 MVPJR|UxKD1iM{[uOFgh|ryP NUL1NpBQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2N|E4QDhpPkK5OlMyPzh6PD;hQi=>
UO31 M2\mdmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MXTMR|UxKD1iM{muPEDPxE1? NF3Cb5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SN12C NILuR2FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MofpUGM2OCB;IEO5Mlgh|ryP MmTlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
RXF393 NHPBPHNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2GwbWxEPTBiPTCzPU45KM7:TR?= M4P0WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
SNB75 MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3zDTmxEPTBiPTCzPU45KM7:TR?= M3XjUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
SF268 MnSyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MYfMR|UxKD1iM{muPEDPxE1? NV;F[FBbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
NCI-H23 M3rXbWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MnTyUGM2OCB;IEO5Mlgh|ryP M4nRZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
HT-29 MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MVrMR|UxKD1iM{muPEDPxE1? M3rRXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
HOP92 M1TLWWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 Mn\OUGM2OCB;IEO5Mlgh|ryP M4LWbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
NCI-H460 M37LO2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MVzMR|UxKD1iM{muPEDPxE1? NGjZbIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SW620 MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NIfxXFRNSzVyIE2gN|kvQCEQvF2= Mn[yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
MDA-MB-468 Mm\ORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NGC5SnRNSzVyIE2gN|kvQCEQvF2= M3S1W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
MALME-3M MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXvUS2khRSB|OT64NUDPxE1? NFrpbGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
Assay
Methods Test Index PMID
Western blot LC3-I / LC-3II / ATG5 ; p-STAT3 / STAT3 / Mcl-1 ; β-catenin / Survivin / Mcl-1 / PTMA ; pERK / ERK ; p-PKM2(y105) / PMK2 / Caspase-9 ; RET(pY1016) / VEGFR2(pY1214) / MEK1(pT292) / ERK(pY204) ; Cyclin D1 23392173 26517516 22286758 26959741 22941289 26039995
Growth inhibition assay Cell viability 26039995
Immunofluorescence p65 ; cytochrome c 22286758 22278289
ELISA TGF-beta / CD206 ; Caspase-9 / Caspase-3 26158762 30923462
In vivo Oral administration of Sorafenib (~60 mg/kg) demonstrates broad spectrum, dose-dependent anti-tumor activity against a variety of human tumor xenograft models including MDA-MB-231, Colo-205, HT-29, DLD-1, NCI-H460, and A549, with no evidence of toxicity. In association with the anti-tumor efficacy, Sorafenib treatment potently inhibits MEK 1/2 phosphorylation and pERK 1/2 levels in HT-29 and MDA-MB-231 xenografts but not in Colo-205 xenografts, and significantly suppresses tumor microvessel area (MVA) and microvessel density (MVD) in MDA MB-231, HT-29 and Colo-205 tumor xenografts. [1] Sorafenib treatment produces dose-dependent growth inhibition of PLC/PRF/5 tumor xenografts in SCID mice with TGIs of 49% and 78% at 10 mg/kg and 30 mg/kg, respectively, consistent with the inhibition of ERK and eIF4E phosphorylation, reduction of the microvessel area, and induction of tumor cell apoptosis. [2] Sorafenib sensitizes bax-/- cells to TRAIL in a dose-dependent manner, through a mechanism involving down-regulating NF-κB mediated Mcl-1 and cIAP2 expression. Combining Sorafenib (30-60 mg/kg) with TRAIL (5 mg/kg) show dramatic efficacy in TRAIL-resistant HCT116 bax-/- and HT29 tumor xenografts. [3]

Protocol (from reference)

Kinase Assay:

[1]

  • Biochemical assays:

    Recombinant baculoviruses expressing Raf-1 (residues 305–648) and B-Raf (residues 409–765) are purified as fusion proteins. Full-length human MEK-1 is generated by PCR and purified as a fusion protein from Escherichia coli lysates. Sorafenib tosylate is added to a mixture of Raf-1 (80 ng), or B-Raf (80 ng) with MEK-1 (1 μg) in assay buffer [20 mM Tris (pH 8.2), 100 mM NaCl, 5 mM MgCl2, and 0.15% β-mercaptoethanol] at a final concentration of 1% DMSO. The Raf kinase assay (final volume of 50 μL) is initiated by adding 25 μL of 10 μM γ[33P]ATP (400 Ci/mol) and incubated at 32 °C for 25 minutes. Phosphorylated MEK-1 is harvested by filtration onto a phosphocellulose mat, and 1% phosphoric acid is used to wash away unbound radioactivity. After drying by microwave heating, a β-plate counter is used to quantify filter-bound radioactivity. Human VEGFR2 (KDR) kinase domain is expressed and purified from Sf9 lysates. Time-resolved fluorescence energy transfer assays for VEGFR2 are performed in 96-well opaque plates in the time-resolved fluorescence energy transfer format. Final reaction conditions are as follows: 1 to 10 μM ATP, 25 nM poly GT-biotin, 2 nM Europium-labeled phospho (p)-Tyr antibody (PY20), 10 nM APC, 1 to 7 nM cytoplasmic kinase domain in final concentrations of 1% DMSO, 50 mM HEPES (pH 7.5), 10 mM MgCl2, 0.1 mM EDTA, 0.015% Brij-35, 0.1 mg/mL BSA, and 0.1% β-mercaptoethanol. Reaction volumes are 100 μL and are initiated by addition of enzyme. Plates are read at both 615 and 665 nM on a Perkin-Elmer VictorV Multilabel counter at ~1.5 to 2.0 hours after reaction initiation. Signal is calculated as a ratio: (665 nm/615 nM) × 10,000 for each well. For IC50 generation, Sorafenib tosylate is added before the enzyme initiation. A 50-fold stock plate is made with Sorafenib tosylate serially diluted 1:3 in a 50% DMSO/50% distilled water solution. Final Sorafenib tosylate concentrations range from 10 μM to 4.56 nM in 1% DMSO.

Cell Research:

[1]

  • Cell lines: MDA-MB-231, and HAoSMC
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 72 hours
  • Method:

    Cells are exposed to increasing concentrations of Sorafenib tosylate for 72 hours. Cell number is quantitated using the Cell TiterGlo ATP Luminescent assay kit. This assay measures the number of viable cells per well by measurement of luminescent signal based on amount of cellular ATP.

  • (Only for Reference)
Animal Research:

[1]

  • Animal Models: Female NCr-nu/nu mice implanted s.c. with MDA-MB-231, Colo-205, HT-29, H460, or A549 cells
  • Dosages: ~60 mg/kg
  • Administration: Orally once daily
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 63 mg/mL
(135.53 mM)
Water Insoluble
Ethanol Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
5%DMSO+45%PEG400+50%H2O
For best results, use promptly after mixing.

0.375mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 464.82
Formula

C21H16ClF3N4O3

CAS No. 284461-73-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05068752 Recruiting Drug: Vemurafenib|Drug: Sorafenib Pancreas Cancer HonorHealth Research Institute|Bayer|Genentech Inc. October 28 2021 Phase 2
NCT04763408 Recruiting Drug: Lenvatinib|Drug: Sorafenib Carcinoma Hepatocellular Eisai Inc. April 9 2021 --
NCT04000737 Recruiting Drug: YIV-906+Sorafenib|Drug: Placebo+Sorafenib Advanced Hepatocellular Carcinoma Yiviva Inc. January 10 2020 Phase 2
NCT03958669 Unknown status -- Hepatocellular Carcinoma|Sorafenib University Hospital Tuebingen|German Federal Ministry of Education and Research November 1 2019 --
NCT03764293 Active not recruiting Drug: SHR-1210|Drug: Apatinib|Drug: Sorafenib Locally Advanced or Metastatic and Unresectable HCC Jiangsu HengRui Medicine Co. Ltd. June 10 2019 Phase 3
NCT03582618 Active not recruiting Drug: Sorafenib|Drug: CVM-1118 Hepatocellular Carcinoma|Advanced Cancer TaiRx Inc. July 12 2018 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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