Sorafenib (BAY 43-9006)

Catalog No.S7397 Synonyms: NSC-724772,BAY 43-9006

For research use only.

Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.

Sorafenib (BAY 43-9006) Chemical Structure

CAS No. 284461-73-0

Selleck's Sorafenib (BAY 43-9006) has been cited by 443 publications

Purity & Quality Control

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Biological Activity

Description Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
Targets
Raf-1 [1]
(Cell-free assay)
mVEGFR2(Flk1) [1]
(Cell-free assay)
mVEGFR3 [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
B-Raf (V599E) [1]
(Cell-free assay)
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6 nM 15 nM 20 nM 22 nM 38 nM
In vitro

Sorafenib inhibits both wild-type and V599E mutant B-Raf activity with IC50 of 22 nM and 38 nM, respectively. Sorafenib also potently inhibits mVEGFR2 (Flk-1), mVEGFR3, mPDGFRβ, Flt3, and c-Kit with IC50 of 15 nM, 20 nM, 57 nM, 58 nM, and 68 nM, respectively. Sorafenib weakly inhibits FGFR-1 with IC50 of 580 nM. Sorafenib tosylate is not active against ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-Met, PKB, PKA, cdk1/cyclinB, PKCα, PKCγ, and pim-1. Sorafenib markedly inhibits VEGFR2 phosphorylation in NIH 3T3 cells with IC50 of 30 nM, and Flt-3 phosphorylation in HEK-293 cells with IC50 of 20 nM. Sorafenib potently blocks MEK 1/2 and ERK 1/2 phosphorylation in most cell lines but not in A549 or H460 cells, while having no effect on inhibition of the PKB pathway. Sorafenib inhibits the proliferation of HAoSMC and MDA-MB-231 cells with IC50 of 0.28 μM and 2.6 μM, respectively. [1] In addition to inhibition of the RAF/MEK/ERK signaling pathway, Sorafenib significantly inhibits the phosphorylation of eIF4E and down-regulates Mcl-1 levels in hepatocellular carcinoma (HCC) cells in a MEK/ERK-independent manner. Sorafenib inhibits the proliferation of PLC/PRF/5 and HepG2 cells with IC50 of 6.3 μM and 4.5 μM, respectively, and leads to the significant induction of apoptosis. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 NFzMZmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMECwNFA{ODNizszN MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
MONO-MAC-6 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEC0NVgh|ryP NIjtNYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
ALL-PO NIKwUmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz3[FJKSzVyPUCuNFMyQDRizszN M4npdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
NKM-1 Ml36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmK1TWM2OD1yLkC3OFE3KM7:TR?= NY\FbllKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
CGTH-W-1 Ml\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPjTWM2OD1yLkK1NFIzKM7:TR?= M1TEcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
BB65-RCC NWXBXGpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDIe41KSzVyPUCuOFcxPzNizszN M{jnXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
NOS-1 NISwb4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwNU[zOkDPxE1? NIjHUG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
SH-4 NV[wNXA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUW3dJlEUUN3ME2wMlY2PjF|IN88US=> MlHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
HOP-62 MnO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlS3TWM2OD1yLki1NFg5KM7:TR?= NV;ON4dsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
HCC2998 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fkTWlEPTB;MD64PFgyQCEQvF2= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
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KM12 NXfxfZVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTFwMEKwPVgh|ryP NXTUcotqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
LB2518-MEL NXTo[4x4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TM[GlEPTB;MT6yNFgxQSEQvF2= NGHpcWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
NCI-H1436 NGHEc|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH3fXN1UUN3ME2xMlIyPjd6IN88US=> M1nnblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
EM-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmC2TWM2OD1zLkO1OVc5KM7:TR?= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
LAMA-84 MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEG1UYpKSzVyPUGuN|c3PDhizszN NFLkSlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
KG-1 M3fmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn34TWM2OD1zLkS3PVM2KM7:TR?= NFq5NGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
A388 NWTGWFlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zafGlEPTB;MT61PVE3PSEQvF2= NYG4WHFXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
no-10 MlKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3y5PWlEPTB;MT62NVczPiEQvF2= NVztNmsyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
SF126 NW\Qbo9jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrKTWM2OD1zLk[zPFEzKM7:TR?= NE\pfZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
MEG-01 MlPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTFwOEC5PEDPxE1? NWnZW4hVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
A3-KAW MkXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jWc2lEPTB;MT64PFQzKM7:TR?= M{\3O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
D-247MG M4jVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTJwMUS0PEDPxE1? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
OVCAR-4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7kTWM2OD1{LkKxN|k{KM7:TR?= NWW3UYpWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
NCI-SNU-1 M1:xT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF21c3JKSzVyPUKuN|E3OiEQvF2= NFrSZ2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
NCI-H2171 M1rvXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjXXHZKSzVyPUKuN|k4PjRizszN NEi5[mQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
SIG-M5 M{PVdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJwNEKyOFIh|ryP M3e2bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
BE-13 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJwNkm2NFkh|ryP MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxN|M3Nyd-U1HOS2VTRC:jPh?=
K052 MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfoPHBXUUN3ME2yMlc1PjF4IN88US=> NFXo[4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
L-540 NH;YVnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfKSWFIUUN3ME2yMlc2Pzh7IN88US=> NUDwfVdiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTN|Nj:nQnNCVkeHUkyvZV4>
KMOE-2 M4LYZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWzWXFOUUN3ME2yMlgyOzVizszN MnvuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVM{Pi9pPmPBUmdGWjxxYU6=
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MZ1-PC MljpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTlcHVQUUN3ME2zMlQ4PTB7IN88US=> M174ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE{OzZxJ{7TRW5ITVJ:L3G+
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BC-1 MmLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzzTWM2OD1|Lke0NFIh|ryP NIn0bmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOzN4Lze+V2FPT0WUPD;hQi=>
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F-6-8 MYPDfZRwfG:6aXPpeJkh[XO|YYm= NEfoSGpKSzVyIE2gNU4{KM7:TR?= MlnZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MUi5PVgoRjJ4M{G4PVk5RC:jPh?=
A549 M4jD[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NFHOVpBKSzVyIE2gNU41PSEQvF2= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN2MkGzOEc,OjZ|NEKxN|Q9N2F-
rhabdomyosarcoma MmLqRY51cX[rcnHsJIFkfGm4aYT5JIF{e2G7 MnnXSWM2OCB;IEGuOUDPxE1? NYe0VHF2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyPFgyQDZpPkK3Nlg5OTh4PD;hQi=>
HL-60(TB) MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVfHTVUxKD1iMT61PEDPxE1? NV3nNYhuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
RPMI8226 M1\xdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWHvdnBjT0l3MDC9JFEvPThizszN M3K4O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
KM12 M1[xZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYHHTVUxKD1iMT61PEDPxE1? NUfpPIxDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
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HCT116 M4nFUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlLpS2k2OCB;IEGuOVgh|ryP MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
HOP92 MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXPiZmo2T0l3MDC9JFEvPThizszN MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
SF539 NFKy[XZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUPHTVUxKD1iMT61PEDPxE1? M13YRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
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SF295 NWnT[FJ{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2HIXmdKPTBiPTCxMlU5KM7:TR?= NEjaXpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
MDA-MB-435 NEfiT5FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml31S2k2OCB;IEGuOVgh|ryP NXLJUZUzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
SK-MEL-5 M2O0[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{nHdGdKPTBiPTCxMlU5KM7:TR?= MmTTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
T47D NUPCOZFxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXTHTVUxKD1iMT61PEDPxE1? NF7NTlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
RPMI8266 M13pZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> NEDoWWVIUTVyIE2gNU42QCEQvF2= NFuy[Vg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
HL-60(TB) MX;DfZRwfG:6aXPpeJkh[XO|YYm= NHrlNoJIUTVyIE2gNU42QCEQvF2= M{PGPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
KM12 MWLDfZRwfG:6aXPpeJkh[XO|YYm= MoK0S2k2OCB;IEGuOVgh|ryP M3\IOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
HCT116 Mmi0R5l1d3SxeHnjbZR6KGG|c3H5 MkHyS2k2OCB;IEGuOVgh|ryP MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
SF295 NVLNVnVTS3m2b4TvfIlkcXS7IHHzd4F6 MmHES2k2OCB;IEGuOVgh|ryP NWH0b49tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
SF539 M37hTWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXnWUmJ7T0l3MDC9JFEvPThizszN MoLoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
SK-MEL-2 M1vCcGN6fG:2b4jpZ4l1gSCjc4PhfS=> MnzES2k2OCB;IEGuOVgh|ryP MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
MDA-MB-435 NFHq[llEgXSxdH;4bYNqfHliYYPzZZk> NEPGR|VIUTVyIE2gNU42QCEQvF2= MnvqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
SK-MEL-5 MULDfZRwfG:6aXPpeJkh[XO|YYm= MmW5S2k2OCB;IEGuOVgh|ryP NYS4SmZGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
LOXIMVI NH7nV2lEgXSxdH;4bYNqfHliYYPzZZk> MWDHTVUxKD1iMT61PEDPxE1? NWXNeG1rRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
T47D M4DJeGN6fG:2b4jpZ4l1gSCjc4PhfS=> NHzmWHlIUTVyIE2gNU42QCEQvF2= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
SMMC7721 NIPLSFBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M3jqOWlEPTBiPTCxMlU5KM7:TR?= MkflQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5NUO4NVUoRjJ4N{WzPFE2RC:jPh?=
LOXIMVI NX;WWphCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NWPKT2hwT0l3MDC9JFEvPThizszN NWTnO4xLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
UACC62 MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Mo[4S2k2OCB;IEGuOVgh|ryP M3fYTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
SK-MEL-5 NVXySJVOSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MmDuS2k2OCB;IEGuOVgh|ryP MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
KM12 NF\1XmdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NELGZlFIUTVyIE2gNU42QCEQvF2= NVu0XIk2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
MDA-MB-435 MofvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MVzHTVUxKD1iMT61PEDPxE1? NFnjOWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SF539 NGTn[o1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NHzhZ3NIUTVyIE2gNU42QCEQvF2= MmjoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SF295 NXLobYNXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NUTX[49rT0l3MDC9JFEvPThizszN MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
HCT116 MoX4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MX;HTVUxKD1iMT61PEDPxE1? NX7RR|lLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
HOP92 NUPE[Ih2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NGDJUYdIUTVyIE2gNU42QCEQvF2= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
RPMI8226 MUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MVLHTVUxKD1iMT61PEDPxE1? MnLtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
HL-60(TB) NF;1UppCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MVnHTVUxKD1iMT61PEDPxE1? NWPDUJU5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
T47D NXXnTmJzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M4TnVGdKPTBiPTCxMlU5KM7:TR?= NULzbVk3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
7dF3 MUjGeY5kfGmxbjDhd5NigQ>? MVPJR|UxKD1iMT62NkDPxE1? NWXvOWJxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyOlY6OzdpPkK5NlY3QTN5PD;hQi=>
MDA-MB-435 MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MmmyTWM2OCB;IEGuOlch|ryP M{\ke|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{e4PVk2Lz5{NUe3PFk6PTxxYU6=
HL60 Mn;TR5l1d3SxeHnjbZR6KGG|c3H5 NYTHTYxvUUN3MDC9JFEvPjhizszN MnrvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6NUi1OFYoRjJ2OEW4OVQ3RC:jPh?=
SW579 Mn7RRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgbJVu[W5? Ml\ETWM2OCB;IEGuO|Mh|ryP NIf1SGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK0NlU2Oyd-MkiyOFI2PTN:L3G+
MCF7 MnTSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M33jOGlEPTBiPTCxMlg5KM7:TR?= NHnIclg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[zO|EzOyd-MkW2N|cyOjN:L3G+
A375P MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3LjeWlEPTBiPTCxMlkh|ryP M2DQU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUK4OFExLz5{NEGyPFQyODxxYU6=
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HCT116 NIfMeZVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MVnJR|UxKD1iMjFOwG0> M4LIR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEC4PVEyLz5{MkiwPFkyOTxxYU6=
MDA-MB-231 Mlr5R5l1d3SxeHnjbZR6KGG|c3H5 M3PF[2lEPTBiPTCyJO69VQ>? MnriQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NUSwNVcoRjJ|NEW0NFE4RC:jPh?=
NCI-H23 M3vzdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXfFUWZ7T0l3MDC9JFIh|ryP M4i3VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
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HOP62 MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWjadJdCT0l3MDC9JFIh|ryP NF;zb3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
NCI-H226 MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYPHTVUxKD1iMjFOwG0> M3HYU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
HT-29 MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUTHTVUxKD1iMjFOwG0> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
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MCF7 NVn5S4JWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkDJTWM2OCB;IEKuO|gh|ryP MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTFyMkG3OUc,OjlzMEKxO|U9N2F-
MDA-MB-231 NVTldnNMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MlHrTWM2OCB;IEKuPEDPxE1? NGXU[IY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKwNlQxOyd-MkmyNFI1ODN:L3G+
HepG2 MUHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MXHJR|UxKD1iMj64OEDPxE1? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ2MkW1N{c,Ojh{NEK1OVM9N2F-
U937 M1nae2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVTHTVUxKD1iMj64OUDPxE1? NYDTdpNtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNVQ4PTVpPkKyNFE1PzV3PD;hQi=>
A549 MnfaR5l1d3SxeHnjbZR6KGG|c3H5 MoH2TWM2OCB;IEKuPVIh|ryP MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{N{iwNUc,Ojh7Mke4NFE9N2F-
A549 M16xS2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVrYT49EUUN3MDC9JFIvQTJizszN NFzvTGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e3O|AxQSd-Mke3O|cxODl:L3G+
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MDA-MB-231 M4XmTWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NVPPPWNlUUN3MDC9JFMvODhizszN M{O4V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUmxPVM5Lz5{Nkm5NVk{QDxxYU6=
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K562 MlTqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEHkcVhIUTVyIE2gN{4yPiEQvF2= NVjUblZXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
MOLT4 NH3PcYtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmnXS2k2OCB;IEOuNVYh|ryP NIH4c4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
A549/ATCC MknVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUDHTVUxKD1iMz6xOkDPxE1? NFH6NWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
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HOP62 MmjpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn;tWGdKKD1iMz6xOkDPxE1? Mo\xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
NCI-H226 NXvheG41T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4rxVnRIUSB;IEOuNVYh|ryP NF3VVYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
U251 NHzvOJNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkPHWGdKKD1iMz6xOkDPxE1? NYfKOItLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
COLO205 MljOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1jSUnRIUSB;IEOuNVYh|ryP NEno[XA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
M14 MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVrkflhuXEeLIE2gN{4yPiEQvF2= NEDlWII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
HCC2998 MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX6zeFRrT0l3MDC9JFMvOTZizszN MnHIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
SNB75 MmjTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYfBcHk5T0l3MDC9JFMvOTZizszN MnXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
786-0 M4HUXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml;VS2k2OCB;IEOuNVYh|ryP NGnuVXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
A498 M2PwZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEG0cXZVT0liPTCzMlE3KM7:TR?= NXPtbYh[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
HCT15 NFX4OoZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFHrcYlVT0liPTCzMlE3KM7:TR?= NWfjTFJXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
OVCAR3 MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVLHTVUxKD1iMz6xOkDPxE1? MoTqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
OVCAR4 MnLXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV3lT5ptT0l3MDC9JFMvOTZizszN MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
Caki1 NHXXbVFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlPXS2k2OCB;IEOuNVYh|ryP NIrheYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
SNB19 NHHHcHZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGnTTGZIUTVyIE2gN{4yPiEQvF2= NYr2SnE3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
OVCAR5 NWSzdnJXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYfHTVUxKD1iMz6xOkDPxE1? NF7DOnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
DU145 M1q4[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYnsUmlkT0l3MDC9JFMvOTZizszN NIDB[5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
OVCAR8 NXrEVohzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4fZXGdKPTBiPTCzMlE3KM7:TR?= M1fHdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
SN12C MmPqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIDYdpJVT0liPTCzMlE3KM7:TR?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
MDA-MB-231 MmHES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF;2OmFVT0liPTCzMlE3KM7:TR?= M1m5NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
RXF393 MojPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUXHTVUxKD1iMz6xOkDPxE1? Mm\JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
BT549 MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1qycmdKPTBiPTCzMlE3KM7:TR?= NWXLfYJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
K562 MXTDfZRwfG:6aXPpeJkh[XO|YYm= M{[0eGdKPTBiPTCzMlE3KM7:TR?= Mk\NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
MOLT4 NU\WXIp5S3m2b4TvfIlkcXS7IHHzd4F6 NXPKOYg{T0l3MDC9JFMvOTZizszN NY\rOJBYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1PVA2ODhpPkK2OVkxPTB6PD;hQi=>
SNB19 M1PpRWN6fG:2b4jpZ4l1gSCjc4PhfS=> MonJS2k2OCB;IEOuNVYh|ryP M4PKVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
SR MlrkR5l1d3SxeHnjbZR6KGG|c3H5 MU\HTVUxKD1iMz6xOkDPxE1? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
A549 MmOwR5l1d3SxeHnjbZR6KGG|c3H5 MXfHTVUxKD1iMz6xOkDPxE1? MkjtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
OVCAR3 MUnDfZRwfG:6aXPpeJkh[XO|YYm= MXzHTVUxKD1iMz6xOkDPxE1? M3vCbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
OVCAR4 NGru[pJEgXSxdH;4bYNqfHliYYPzZZk> NEiwbI9IUTVyIE2gN{4yPiEQvF2= M4DSO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
SNB75 NYXNVpc1S3m2b4TvfIlkcXS7IHHzd4F6 MlXXS2k2OCB;IEOuNVYh|ryP MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
OVCAR5 MkHTR5l1d3SxeHnjbZR6KGG|c3H5 NV;Pd41{T0l3MDC9JFMvOTZizszN MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
DU145 M1TDXGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1XIeGdKPTBiPTCzMlE3KM7:TR?= NHzBfok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
786-0 Ml74R5l1d3SxeHnjbZR6KGG|c3H5 MVjHTVUxKD1iMz6xOkDPxE1? NETyTlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
BT549 NVjHbVB1S3m2b4TvfIlkcXS7IHHzd4F6 NGfGeGlIUTVyIE2gN{4yPiEQvF2= NEHIVYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
ACHN NV\ydGNYS3m2b4TvfIlkcXS7IHHzd4F6 NX3vb|ZJT0l3MDC9JFMvOTZizszN MlPHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
Caki1 M1jSOmN6fG:2b4jpZ4l1gSCjc4PhfS=> NEjpeYlIUTVyIE2gN{4yPiEQvF2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
786-0 MUHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NXjMU5M5T0l3MDC9JFMvOTZizszN Mn76QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
LOXIMVI Mo[1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4XhOnRIUSB;IEOuNVYh|ryP MnXDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
Caki1 NWLldoRkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MU\HTVUxKD1iMz6xOkDPxE1? MoPCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
OVCAR5 MonyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4\UNmdKPTBiPTCzMlE3KM7:TR?= M{XyVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
RXF393 Mo\3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MXvHTVUxKD1iMz6xOkDPxE1? NEnnSWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SNB75 MknERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NW\ITmQyT0l3MDC9JFMvOTZizszN M3TGV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
OVCAR3 MoDwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NXTUdFNnT0l3MDC9JFMvOTZizszN NWLBNmdQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SNB19 NYHTZm9MSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MkLnS2k2OCB;IEOuNVYh|ryP MnO4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SK-MEL-5 NWPXVI5sSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NYKzTVY{XEeLIE2gN{4yPiEQvF2= M4rWe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
OVCAR4 M1vKNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MXzHTVUxKD1iMz6xOkDPxE1? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
SK-MEL-2 NHL1TlFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2TqSHRIUSB;IEOuNVYh|ryP NXHO[pRGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
BT549 MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NI\0UJFIUTVyIE2gN{4yPiEQvF2= MoLlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
MOLT4 M2S1OWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M2Xje2dKPTBiPTCzMlE3KM7:TR?= NFr1fGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
K562 NEDBU25CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M13mNmdKPTBiPTCzMlE3KM7:TR?= M3jMVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
HCC2998 NX3UU4ZDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MknZS2k2OCB;IEOuNVYh|ryP NH3xXYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
HCC2998 M13UPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NVPTcllMXEeLIE2gN{4yPiEQvF2= MmjxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
A549/ATCC NI[y[GdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NVLUOphxT0l3MDC9JFMvOTZizszN MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
DU145 NH[4U5JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MYPHTVUxKD1iMz6xOkDPxE1? NV7xRZZzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SR MlL1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M1;LSmdKPTBiPTCzMlE3KM7:TR?= M1nUW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
MCF7 MXnDfZRwfG:6aXPpeJkh[XO|YYm= MmnXTWM2OCB;IEOuNVgh|ryP M3ruPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUK3PFAyLz5{OEmyO|gxOTxxYU6=
PC3 NXr5dWRsS3m2b4TvfIlkcXS7IHHzd4F6 NEfrUVFKSzVyIE2gN{4yQCEQvF2= MnnBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7Mke4NFEoRjJ6OUK3PFAyRC:jPh?=
MCF7 MUTDfZRwfG:6aXPpeJkh[XO|YYm= MVnJR|UxKD1iMz6xPEDPxE1? M320eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{e3NFA6Lz5{N{e3O|AxQTxxYU6=
A549 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Mnm2TWM2OCB;IEOuNVkh|ryP MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5OEm5OUc,OjV5N{i5PVU9N2F-
PC3 NIToXllEgXSxdH;4bYNqfHliYYPzZZk> MXnJR|UxKD1iMz6yOEDPxE1? NWnpeoU4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3O|cxODlpPkK3O|c4ODB7PD;hQi=>
HeLa MYPGeY5kfGmxbjDhd5NigQ>? NXHITWYzUUN3MDC9JFMvOyEQvF2= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTJ{NUewOkc,OTV{MkW3NFY9N2F-
HeLa MYPGeY5kfGmxbjDhd5NigQ>? MYLJR|UxKD1iMz6zJO69VQ>? Mn;oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV{MkW3NFYoRjF3MkK1O|A3RC:jPh?=
LoVo MUnDfZRwfG:6aXPpeJkh[XO|YYm= M1PyZmlEPTBiPTCzMlMh|ryP M3\ndlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEW0NFE4Lz5{M{S1OFAyPzxxYU6=
A375 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MnrJTWM2OCB;IEOuN|Yh|ryP NYjaUWxLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2NFI3PzRpPkK5OlAzPjd2PD;hQi=>
HT-29 NGrQfIFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M4PqdGlEPTBiPTCzMlM4KM7:TR?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl7MUmzPEc,OjZ7OUG5N|g9N2F-
FLT3 gene-deficient U937 M1fhVGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M{HsW2dKPTBiPTCzMlQh|ryP NUTqW5g4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3NFg1PjhpPkKxO|A5PDZ6PD;hQi=>
FLT3 negative U937 MVHDfZRwfG:6aXPpeJkh[XO|YYm= NVzmUG95T0l3MDC9JFMvPCEQvF2= MkixQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUi3NFkoRjJ|NkG4O|A6RC:jPh?=
U937 MWXDfZRwfG:6aXPpeJkh[XO|YYm= NWPvOoxJT0l3MDC9JFMvPCEQvF2= M1HWSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEixNFI{Lz5{NkC4NVAzOzxxYU6=
A375P MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M1;uR2dKPTBiPTCzMlQh|ryP MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR3OUG0OEc,Ojl2NUmxOFQ9N2F-
ACHN NYLy[3htS3m2b4TvfIlkcXS7IHHzd4F6 MoKwTWM2OCB;IEOuOEDPxE1? M4Gy[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUG3PVA5Lz5{OUWxO|kxQDxxYU6=
ACHN M3nLeWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUD5fHFnUUN3MDC9JFMvPCEQvF2= MmjvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{OUe2PFgoRjJ7Mkm3Olg5RC:jPh?=
HepG2 MV;GeY5kfGmxbjDhd5NigQ>? MY\JR|UxKD1iMz60JO69VQ>? NITmV2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC3NVg3OSd-Mk[wO|E5PjF:L3G+
A375P MmjLR5l1d3SxeHnjbZR6KGG|c3H5 NUPjSGFyT0l3MDC9JFMvPCEQvF2= M33qc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEe4NVk{Lz5{NEi3PFE6OzxxYU6=
HepG2 NEnhUGVEgXSxdH;4bYNqfHliYYPzZZk> NUPEb4F3UUN3MDC9JFMvPDRizszN MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{N{iwNUc,Ojh7Mke4NFE9N2F-
HepG2 M3njdmN6fG:2b4jpZ4l1gSCjc4PhfS=> M3nuPWlEPTBiPTCzMlQ1KM7:TR?= Mof1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5N{ewNFkoRjJ5N{e3NFA6RC:jPh?=
ACHN M37H[GN6fG:2b4jpZ4l1gSCjc4PhfS=> MVvJR|UxKD1iMz61JO69VQ>? M3XjTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{i2OFM3Lz5{OUe4OlQ{PjxxYU6=
HepG2 MoLkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NVHNOZZ5UUN3MDC9JFMvPSEQvF2= NFi0c3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS2NlI3PSd-MkW0OlIzPjV:L3G+
HT-29 MXHDfZRwfG:6aXPpeJkh[XO|YYm= NHXIeZJKSzVyIE2gN{43OSEQvF2= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh{NkixOUc,OjR6Mk[4NVU9N2F-
HT-29 MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M4jQVWlEPTBiPTCzMlYyKM7:TR?= NXOyTXVNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNVY5PDlpPkOwNlE3QDR7PD;hQi=>
HT-29 MY\DfZRwfG:6aXPpeJkh[XO|YYm= MnrmTWM2OCB;IEOuOlEh|ryP MkLNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOE[yN|goRjJ3MEi2NlM5RC:jPh?=
HT-29 NH[xUpVEgXSxdH;4bYNqfHliYYPzZZk> NXX3dXE{UUN3MDC9JFMvPjFizszN NEn5UXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS0NFg4QSd-MkW0OFA5Pzl:L3G+
MCF7 MYTBcpRq[2GwY3XyJIFkfGm4aYT5JIF{e2G7 NFTEZXRKSzVyIE2gN{43PCEQvF2= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2OUi0NUc,Ojl3NEm4OFE9N2F-
Sf9 MY\GeY5kfGmxbjDhd5NigQ>? NIm0TYZKSzVyIE2gN{45KM7:TR?= MkfnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5MEi0OlgoRjJzN{C4OFY5RC:jPh?=
Sf9 MXTGeY5kfGmxbjDhd5NigQ>? Ml;WTWM2OCB;IEOuPEDPxE1? NXjXSo0{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVg4ODlpPkKzOlE5PzB7PD;hQi=>
Sf9 M17GXGZ2dmO2aX;uJIF{e2G7 M3f0UmlEPTBiPTCzMlgh|ryP MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB6MUCyN{c,OjZyOEGwNlM9N2F-
A2058 NWXzeVVCS3m2b4TvfIlkcXS7IHHzd4F6 NXHxdJJ4UUN3MDC9JFMvQCEQvF2= Mn;zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5MEi5PFcoRjJ{N{C4PVg4RC:jPh?=
NCI-H460 NV\WflRkS3m2b4TvfIlkcXS7IHHzd4F6 NY\NXoJKUUN3MDC9JFMvQSEQvF2= M4G3VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEW0NFE4Lz5{M{S1OFAyPzxxYU6=
SK-MEL-30 NYP6fHJ7S3m2b4TvfIlkcXS7IHHzd4F6 MXnJR|UxKD1iMz65JO69VQ>? M1uyeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NE[xPFI4Lz5{OUS2NVgzPzxxYU6=
HT-29 Mn3pRY51cWOjbnPldkBi[3Srdnn0fUBie3OjeR?= M{P6RmlEPTBiPTCzMlk4KM7:TR?= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2OUi0NUc,Ojl3NEm4OFE9N2F-
SF268 NFj1OJpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NW\iOJNLXEeLIE2gN{46QCEQvF2= NEfQZnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
SNB75 MlO3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlPrWGdKKD1iMz65PEDPxE1? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
OVCAR3 NH62OIVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NULIZ2l3XEeLIE2gN{46QCEQvF2= NWDvbolwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
SNB19 MlvoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXPYXVRGXEeLIE2gN{46QCEQvF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
Hs 578T NEXleIhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFH3OoRVT0liPTCzMlk5KM7:TR?= NVzFXZp[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFgxQDZpPkK4NFg5ODh4PD;hQi=>
TK10 MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFvnfW1IUTVyIE2gN{46QCEQvF2= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6OEC4Okc,OjhyOEiwPFY9N2F-
BT549 M2PVRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlfmWGdKKD1iMz65PEDPxE1? NIr1THo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
Caki1 MmO4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NHLLWJNVT0liPTCzMlk5KM7:TR?= NU[4WpVVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
TK10 NWPlNGRQSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NFLrbotIUTVyIE2gN{46QCEQvF2= NXPPVWRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
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melanoma MknMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX6wOXJZUUN3MDC9JFYvOSEQvF2= M1TO[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4M{myPFI3Lz5zNkO5NlgzPjxxYU6=
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HepG2 NXLzfFd6S3m2b4TvfIlkcXS7IHHzd4F6 M4n1S2lEPTBiPTC2MlIh|ryP MnHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6NkWyO|YoRjJ6OE[1Nlc3RC:jPh?=
A549 Ml\tRY51cWOjbnPldkBi[3Srdnn0fUBie3OjeR?= Mm\ETWM2OCB;IE[uNlEh|ryP NHXCPIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW0PVg1OSd-Mkm1OFk5PDF:L3G+
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SF295 Mn:1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnrpWGdKKD1iNj6zNUDPxE1? NFPhZ409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
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HepG2 MlfPR5l1d3SxeHnjbZR6KGG|c3H5 NEfOVHZKSzVyIE2gOk44KM7:TR?= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF3OUS4N{c,OjZzNUm0PFM9N2F-
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SGC7901 NWfyWlh5S3m2b4TvfIlkcXS7IHHzd4F6 NFvz[25KSzVyIE2gOk46KM7:TR?= M2H4cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEW0NFE4Lz5{M{S1OFAyPzxxYU6=
OS-RC2 NH:1W3REgXSxdH;4bYNqfHliYYPzZZk> NUDxUW1EUUN3MDC9JFch|ryP NX[wbWc{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1NVc6ODhpPkK5OVE4QTB6PD;hQi=>
OS-RC2 MV7DfZRwfG:6aXPpeJkh[XO|YYm= NXnIfJJMUUN3MDC9JFch|ryP M3O5V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mkm3Olg5Lz5{OUK5O|Y5QDxxYU6=
COLO205 NV\XW452SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkhcHWvYX6= MlryTWM2OCB;IEeuNFQh|ryP M{HyNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkSyOVU{Lz5{OEK0NlU2OzxxYU6=
rhabdomyosarcoma NH;KRpNEgXSxdH;4bYNqfHliYXP0bZZqfHliYXfhbY5{fCCqdX3hci=> M1TVeWNEPTBiPTC3MlA2KM7:TR?= M{DwN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Mki4NVg3Lz5{N{K4PFE5PjxxYU6=
HuH7 M17peGN6fG:2b4jpZ4l1gSCjc4PhfS=> NYCwXoxIUUN3MDC9JFcvOSEQvF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF3OUS4N{c,OjZzNUm0PFM9N2F-
MDA-MB-231 NIfjWWlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NYDxNVNHUUN3MDC9JFcvOThizszN NIHpXWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkeyNVkzPCd-MkK3NlE6OjR:L3G+
FLT3-negative K562 NVnVZ4FQS3m2b4TvfIlkcXS7IHHzd4F6 M{izWmdKPTBiPTC3MlMh|ryP NGLDVVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xPFcxQSd-MkO2NVg4ODl:L3G+
K562 MlrWSpVv[3Srb36gZZN{[Xl? NGe3OVFIUTVyIE2gO{4{KM7:TR?= MmLNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyOEGwNlMoRjJ4MEixNFI{RC:jPh?=
K562 NGC4NVNHfW6ldHnvckBie3OjeR?= M4\hc2dKPTBiPTC3MlMh|ryP M2\w[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEixNFI{Lz5{NkC4NVAzOzxxYU6=
MCF7 NYCzZoVSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NETEXY1KSzVyIE2gO{4{OyEQvF2= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEKxPUc,OjN4NESyNVk9N2F-
A549 MnHWR5l1d3SxeHnjbZR6KGG|c3H5 NUm2N41kXEeLIE2gO{4{PiEQvF2= M{XlNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
WI38 NWG1XFl1S3m2b4TvfIlkcXS7IHHzd4F6 NIP4SFhKSzVyIE2gO{42PCEQvF2= MnLVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6Mk[4NVUoRjJ2OEK2PFE2RC:jPh?=
A375 NVPPPWFDS3m2b4TvfIlkcXS7IHHzd4F6 M2fRPWlEPTBiPTC3MlU3KM7:TR?= NWnVS4NqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVU5OThpPkK0NlE2QDF6PD;hQi=>
MDA-MB-231 NU\LRYZqS3m2b4TvfIlkcXS7IHHzd4F6 M2f0[mlEPTBiPTC3MlYzKM7:TR?= NH\aVWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG4NVQyPCd-MkCxPFE1OTR:L3G+
786-0 MnfwR5l1d3SxeHnjbZR6KGG|c3H5 NH7qdlZVT0liPTC3MlYzKM7:TR?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV7MEWwPEc,OjZ3OUC1NFg9N2F-
HS27 NET2R4tCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NF;yPGRKSzVyIE2gO{45KM7:TR?= NIHVTnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUi1O|k3Oyd-MUm4OVc6PjN:L3G+
HS27 M{jEV2N6fG:2b4jpZ4l1gSCjc4PhfS=> MXHJR|UxKD1iNz64JO69VQ>? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh7N{O2Okc,OTl6OUezOlY9N2F-
HCT116 NIDtUndEgXSxdH;4bYNqfHliYYPzZZk> M4\HWWlEPTBiPTC3Mlgh|ryP NXzJb5lSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFM2QTJpPkKyOFg{PTl{PD;hQi=>
HS27 NE\zNmNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2XmOWlEPTBiPTC3Mlg2KM7:TR?= NF3PW2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUS2OFg5Pyd-MUm0OlQ5QDd:L3G+
HS27 M2fjNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NYnqfWtST0l3MDC9JFcvQDVizszN M2rrN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{WzOVcyLz5{MUO1N|U4OTxxYU6=
A549/ATCC NXnSUHJtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIrvXHBVT0liPTC3Mlk1KM7:TR?= MmPEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
DU145 NUf4RpJQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXvUS2khRSB5Lkm0JO69VQ>? NGjaVYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4PFA5Pid-MkiwPFgxQDZ:L3G+
NCI/ADR-RES MmeyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoC3WGdKKD1iNz65OEDPxE1? MlH6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
MCF7 M1jBXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUfHNZJsXEeLIE2gO{46PCEQvF2= MkS3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
PC3 MofRRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MVvUS2khRSB5Lkm0JO69VQ>? NInnZlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
UO31 MlvvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MXXUS2khRSB5Lkm0JO69VQ>? M1vseVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
NCI-ADR-RES MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NF74bIVVT0liPTC3Mlk1KM7:TR?= NUXQWGdKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
LOXIMVI M37rSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MVvMR|UxKD1iNz65OEDPxE1? MoPLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
SK-MEL-28 NIPXdWxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M4fEWHRIUSB;IEeuPVQh|ryP MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
KM12 M2W1O2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NGDLNmNVT0liPTC3Mlk1KM7:TR?= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
COLO205 MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Moj5WGdKKD1iNz65OEDPxE1? MlTNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
HT-29 M4[wXmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NY\2RZVWXEeLIE2gO{46PCEQvF2= NYrkeVBiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
NCI-H226 M4nMcmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MVvUS2khRSB5Lkm0JO69VQ>? M17F[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
HOP62 Mn3WRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4nEUnRIUSB;IEeuPVQh|ryP NYmxVGhKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
T47D MnrHRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MYfUS2khRSB5Lkm0JO69VQ>? MnG1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
MDA-MB-468 M{PNNGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MYHUS2khRSB5Lkm0JO69VQ>? NHi2RWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
EKVX MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NGHrR4FVT0liPTC3Mlk1KM7:TR?= MonXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
MCF7 NUH6UnBMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M4TNUnRIUSB;IEeuPVQh|ryP MoHRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
Hs 578T M1HTemFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MUfUS2khRSB5Lkm0JO69VQ>? NG\DTnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
MGC803 MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MmfETWM2OCB;IEeuPVkh|ryP NEP5XYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW2NFA1QSd-Mk[1OlAxPDl:L3G+
HCT116 MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MoHZTWM2OCB;IEiuNFgh|ryP MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR2MES3PUc,OjR2NEC0O|k9N2F-
PC3 MnTYR5l1d3SxeHnjbZR6KGG|c3H5 M17CfWlEPTBiPTC4MlA5KM7:TR?= NUjEeox6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewOFMzPjhpPkK3NFQ{OjZ6PD;hQi=>
HCT116 MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3O0OWlEPTBiPTC4MlA5KM7:TR?= NVnsXWNiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTlpPkKzOlQ1OjF7PD;hQi=>
WM266.4 MnnMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M3jLN2dKPTBiPTC4MlEh|ryP MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB{NUm5Okc,OjNyMkW5PVY9N2F-
WM266.4 MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MVvHTVUxKD1iOD6xNkDPxE1? M2TNbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUizOlY6Lz5{MkW4N|Y3QTxxYU6=
Ketr3 NV;kcZc6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NET4dFdKSzVyIE2gPE4zPyEQvF2= NUDlPWlVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNVY5PDlpPkOwNlE3QDR7PD;hQi=>
A375 MlLBRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MXLJR|UxKD1iOD6yO{DPxE1? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJzNki0PUc,OzB{MU[4OFk9N2F-
HepG2 NF70dFZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MXzJR|UxKD1iOD6yO{DPxE1? MmG5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MU[4OFkoRjNyMkG2PFQ6RC:jPh?=
MX1 NETmZ3hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NEjOc21KSzVyIE2gPE4zPyEQvF2= NX\sc2lFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNVY5PDlpPkOwNlE3QDR7PD;hQi=>
MX1 M4DRSGN6fG:2b4jpZ4l1gSCjc4PhfS=> MVHJR|UxKD1iOD6yO{DPxE1? M4\kSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Nke1NVM2Lz5{NE[3OVE{PTxxYU6=
WM266.4 M2X3S2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIC2eZlIUTVyIE2gPE4{KM7:TR?= NVzUZmVYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzOlE3QDZpPkKyN|YyPjh4PD;hQi=>
PLC/PRF/5 NGS5TXdEgXSxdH;4bYNqfHliYYPzZZk> MWjJR|UxKD1iOD6zJO69VQ>? Ml;KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3M{GwOVMoRjJzNUOxNFU{RC:jPh?=
A375 MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M{HnfWlEPTBiPTC4MlM{KM7:TR?= M4OzPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OEi2N|I1Lz5{OUi4OlMzPDxxYU6=
HCT116 MlvER5l1d3SxeHnjbZR6KGG|c3H5 MX\JR|UxKD1iOD60NUDPxE1? NGj3WXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[zNVc5QCd-Mkm2N|E4QDh:L3G+
WI38 NGq1eItEgXSxdH;4bYNqfHliYYPzZZk> NWLVU5RZUUN3MDC9JFgvPDJizszN NFqxVHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nkm5NVk{QCd-Mk[5PVE6Ozh:L3G+
HepG2 NEH0NXlEgXSxdH;4bYNqfHliYYPzZZk> NITUeW5KSzVyIE2gPE41OiEQvF2= NFPsWnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G2NlEzOyd-MkexOlIyOjN:L3G+
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HepG2 NUfsVnpDS3m2b4TvfIlkcXS7IHHzd4F6 MoDuTWM2OCB;IEiuOlch|ryP MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ5NUGzOUc,OjR4N{WxN|U9N2F-
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MCF7 NXfsT2dFS3m2b4TvfIlkcXS7IHHzd4F6 MWXJR|UxKD1iOT6xNkDPxE1? NEfrbZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOwNFkzOCd-MkSzNFA6OjB:L3G+
HepG2 NE\yVIlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Ml\YTWM2OCB;IEmuNVQh|ryP MmLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3NkCwOFkoRjJ4NU[wNFQ6RC:jPh?=
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RS4:11 NYXORZJiTnWwY4Tpc44h[XO|YYm= MV3HTVUxKD1iOT6zJO69VQ>? NHywcIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC4NVAzOyd-Mk[wPFExOjN:L3G+
RS4:11 M4TUS2N6fG:2b4jpZ4l1gSCjc4PhfS=> MoLvS2k2OCB;IEmuN{DPxE1? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzOEewPUc,OjN4MUi3NFk9N2F-
MIAPaCa2 MoW4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NVfHdo0{UUN3MDC9JFkvOzJizszN NYj2eVBqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwN|IxOzFpPkK5NFMzODNzPD;hQi=>
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RS4:11 NYThVJV3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MWfHTVUxKD1iOT60JO69VQ>? NITFUHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUewPFQ3QCd-MkG3NFg1Pjh:L3G+
Hep3B MnKxR5l1d3SxeHnjbZR6KGG|c3H5 NIDLNFlKSzVyIE2gPU41KM7:TR?= NF\nOYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEi2OVI4Pid-Mki4OlUzPzZ:L3G+
LoVo NV\JTHVzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkTuTWM2OCB;IEmuOFch|ryP NHPBWm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGwNlE4PSd-MkmxNFIyPzV:L3G+
SMMC7721 NXLPOlNSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Mnv5TWM2OCB;IEmuPVYh|ryP NF[3W3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[zO|EzOyd-MkW2N|cyOjN:L3G+
MCF7 MkXvR5l1d3SxeHnjbZR6KGG|c3H5 NGnrenVVT0liPTC5Mlk4KM7:TR?= NGrx[4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
IGROV1 NWXUeWNxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVz1c3VPXEeLIE2gNVAh|ryP MoDRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
ACHN MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWTzeoxTXEeLIE2gNVAh|ryP M172RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
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786-0 MUnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M131Z3RIUSB;IEGwJO69VQ>? NYnUXpE4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
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Caki1 MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Mn\5UGM2OCB;IEGwJO69VQ>? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
TK10 NUDpb25jSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NVnuTW9PXEeLIE2gNVAh|ryP MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
RXF393 MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MXfUS2khRSBzMDFOwG0> NHPv[HU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
OVCAR8 M2LtPGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MU\US2khRSBzMDFOwG0> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
SNB75 NWnM[VhCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MmrtWGdKKD1iMUCg{txO NEjuNGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
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MDA-MB-435 NGD3cGJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MW\MR|UxKD1iMUCg{txO NVu3[YR6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
SF539 MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M{PwRnRIUSB;IEGwJO69VQ>? M3nNWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
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Bel7402 M1rEXWN6fG:2b4jpZ4l1gSCjc4PhfS=> NIXqbYJKSzVyIE2gNVAvOjZizszN NYHDfGhORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1NFQzODRpPkKxOVA1OjB2PD;hQi=>
Bel7402 NG\TeFRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWDxSlJqUUN3MDC9JFExNjNzIN88US=> Ml7VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzMEKxO|UoRjJ7MUCyNVc2RC:jPh?=
OVCAR3 M2m5emN6fG:2b4jpZ4l1gSCjc4PhfS=> M2nxOXRIUSB;IEGwMlMzKM7:TR?= NGXRUmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
SGC7901 MUjDfZRwfG:6aXPpeJkh[XO|YYm= MXTJR|UxKD1iMUCuN|ch|ryP Ml;3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2M{W0O|koRjJyNEO1OFc6RC:jPh?=
SNB75 NE\vW3REgXSxdH;4bYNqfHliYYPzZZk> M{[w[3RIUSB;IEGwMlQzKM7:TR?= NIDMUZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
A431 MkLGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MniyTWM2OCB;IEGwMlQ3KM7:TR?= NX3VeVdURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwN|IxOzFpPkK5NFMzODNzPD;hQi=>
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GES-1 MmWyR5l1d3SxeHnjbZR6KGG|c3H5 NHX0cY5KSzVyIE2gNVAvPjhizszN MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF4MkGyN{c,OjdzNkKxNlM9N2F-
H460 NXzZPZBDS3m2b4TvfIlkcXS7IHHzd4F6 M33qOmlEPTBiPTCxNE45KM7:TR?= NYX1NlNGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNFA6OjBpPkK0N|AxQTJyPD;hQi=>
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Hep3B MYfDfZRwfG:6aXPpeJkh[XO|YYm= NV7UeG55UUN3MDC9JFEyNjJizszN NFnXR|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO0NlQxOCd-MkizOFI1ODB:L3G+
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HeLa M2PUN2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M4PZdmlEPTBiPTCxNk4xOSEQvF2= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTFyM{i3N{c,OjlzMEO4O|M9N2F-
PANC1 MWrDfZRwfG:6aXPpeJkh[XO|YYm= MYjJR|UxKD1iMUKuN{DPxE1? NFq1[Zk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOwNFkzOCd-MkSzNFA6OjB:L3G+
HepG2 NYH6[lRYSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NFjaU2VKSzVyIE2gNVIvPTRizszN NHPhW409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUCzNlA{OSd-MkmwN|IxOzF:L3G+
A549 NVfUTVVLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NIGxNJFKSzVyIE2gNVIvPTRizszN MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEKxPUc,OjN4NESyNVk9N2F-
Caki1 M1HmSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWf4NohCXEeLIE2gNVIvPTlizszN MoS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
OVCAR8 M2j6NGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXTKS5BuXEeLIE2gNVIvPTlizszN Mkj6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEiwPFYoRjJ6MEi4NFg3RC:jPh?=
SKOV3 MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Mnz6WGdKKD1iMUKuOkDPxE1? MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
ACHN NIjVc25CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MWTUS2khRSBzMj62JO69VQ>? NHjGOmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
OVCAR3 MmLGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MWrUS2khRSBzMj62JO69VQ>? NGrqR3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
OVCAR4 NF3DV|VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NXfmPIZ5XEeLIE2gNVIvPiEQvF2= NYnHPJNnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
HCT15 MoXIRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MWPUS2khRSBzMj62JO69VQ>? NH\hdWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
SW620 M3LMWGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M4LhN3RIUSB;IEGyMlYh|ryP NFPTVWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
A549/ATCC MnXmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NYfBXnQ2XEeLIE2gNVIvPiEQvF2= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
MDA-MB-468 MnzsR5l1d3SxeHnjbZR6KGG|c3H5 M3G0TnRIUSB;IEGzMlA6KM7:TR?= MoTZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
SK-MEL-28 MYrDfZRwfG:6aXPpeJkh[XO|YYm= M{fhenRIUSB;IEGzMlM6KM7:TR?= Ml;6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
A549 M4C2RmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MWDJR|UxKD1iMUOuOlQh|ryP NVvWWG5zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1OlAxPDlpPkK2OVYxODR7PD;hQi=>
A375 MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDoeY1idg>? M1TN[2lEPTBiPTCxN{43PCEQvF2= MnHCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{NEK1OVMoRjJ6MkSyOVU{RC:jPh?=
A375 NYDJOYdlSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NFzqUpFKSzVyIE2gNVMvPjRizszN NFL4TlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS2NlI3Pyd-MkW0OlIzPjd:L3G+
K562 NH;yRllCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{HSfmlEPTBiPTCxN{45PSEQvF2= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEKxPUc,OjN4NESyNVk9N2F-
Hep3B NGS0W|dEgXSxdH;4bYNqfHliYYPzZZk> Mk\JTWM2OCB;IEG0MlA5KM7:TR?= M1ThbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUC0NlA1Lz5{MUWwOFIxPDxxYU6=
T47D NHjIUYlEgXSxdH;4bYNqfHliYYPzZZk> Mlz6WGdKKD1iMUSuN|gh|ryP NEXxNlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
NCI-H226 M{f6fWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXTwUpNOXEeLIE2gNVQvPDJizszN MnvjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OUC1NFgoRjJ4NUmwOVA5RC:jPh?=
MDA-MB-231 MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M1nMUmlEPTBiPTCxOE43OiEQvF2= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR2MES3PUc,OjR2NEC0O|k9N2F-
MDA-MB-231 M3;EcGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NWXUTZV4UUN3MDC9JFE1NjZ{IN88US=> NWDON|RHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTlpPkKzOlQ1OjF7PD;hQi=>
NCI-H522 MV\DfZRwfG:6aXPpeJkh[XO|YYm= MmXnWGdKKD1iMUSuPFIh|ryP NGTEeos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
SK-MEL-2 M4H5e2N6fG:2b4jpZ4l1gSCjc4PhfS=> NIfjVmtVT0liPTCxOE45PSEQvF2= M1XNNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUmwOVA5Lz5{NkW5NFUxQDxxYU6=
OS-RC2 M{TqcWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUn5OYRWUUN3MDC9JFE2KM7:TR?= NIHDbVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUe4OlQ{Pid-Mkm3PFY1OzZ:L3G+
HepG2 MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3fTOGlEPTBiPTCxOUDPxE1? NEewWZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGwN|g4Oyd-MkmxNFM5PzN:L3G+
fibroblast MlTjRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MlL5TWM2OCB;IEG1MlEh|ryP NXnpfYNSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0O|c2ODVpPkG4OFc4PTB3PD;hQi=>
HT-29 NVX2N5hvS3m2b4TvfIlkcXS7IHHzd4F6 M{D2NmlEPTBiPTCxOU4zKM7:TR?= NXrKfopMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2O|UyOzVpPkK0Olc2OTN3PD;hQi=>
U87MG MVTDfZRwfG:6aXPpeJkh[XO|YYm= NVLicopNUUN3MDC9JFE2NjV5IN88US=> NHzBco49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEiyOlgyPSd-MkS4NlY5OTV:L3G+
BT549 M{P2SWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MlfKUGM2OCB;IEG1Mlgh|ryP M4PrPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
GES-1 NV\T[|lxS3m2b4TvfIlkcXS7IHHzd4F6 MkS1TWM2OCB;IEG1Mlgh|ryP MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh5MUmwPUc,OjN6N{G5NFk9N2F-
SNB19 NES3eVZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NUjhPXpJXEeLIE2gNVUvQDVizszN MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzN{W0PUc,OjdyMUe1OFk9N2F-
IGROV1 NI\McWRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NXOyT2l1XEeLIE2gNVUvQSEQvF2= MlHRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
HCT116 M{H0ZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MUTMR|UxKD1iMUWuPUDPxE1? MkjrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUe1OFkoRjJ5MEG3OVQ6RC:jPh?=
OS-RC2 MX7DfZRwfG:6aXPpeJkh[XO|YYm= MVvJR|UxKD1iMU[g{txO MoLBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NUSwNVcoRjJ|NEW0NFE4RC:jPh?=
A375 NUHzTWVHS3m2b4TvfIlkcXS7IHHzd4F6 MXTJR|UxKD1iMU[uNlQh|ryP MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR4MUOxPEc,OjV2NkGzNVg9N2F-
SKOV3 NXHaUWVwS3m2b4TvfIlkcXS7IHHzd4F6 NWHkbVY2XEeLIE2gNVYvOzZizszN NFnYOZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
WM1361 NF7tdZJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MVPJR|UxKD1iMU[uOFQh|ryP M17sT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkCyOlc1Lz5{OU[wNlY4PDxxYU6=
MKN28 MmnVRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NUK2dWhGUUN3MDC9JFE4KM7:TR?= NH\xbIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUCzNlA{OSd-MkmwN|IxOzF:L3G+
SMMC7721 NVO0XIdMS3m2b4TvfIlkcXS7IHHzd4F6 MYLJR|UxKD1iMUeuN{DPxE1? MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTVyNEKwOEc,OjF3MESyNFQ9N2F-
UACC257 NVPxUVJNS3m2b4TvfIlkcXS7IHHzd4F6 Mn6yWGdKKD1iMUeuN|Mh|ryP NEG2fZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW5NFUxQCd-Mk[1PVA2ODh:L3G+
EAhy926 M3r2Z2FvfGmjbnfpc4dmdmmlIHHjeIl3cXS7IHHzd4F6 NXPWfVFUUUN3MDC9JFE5NjV{IN88US=> M3X6W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEOyNFMyLz5{OUCzNlA{OTxxYU6=
SMMC7721 MVXDfZRwfG:6aXPpeJkh[XO|YYm= MVnJR|UxKD1iMUiuO{DPxE1? NIPD[|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOwNFkzOCd-MkSzNFA6OjB:L3G+
Ketr3 MkL0R5l1d3SxeHnjbZR6KGG|c3H5 NI\2OY5KSzVyIE2gNVgvQCEQvF2= NVfYSIxpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2O|UyOzVpPkK0Olc2OTN3PD;hQi=>
NCI-H522 NHfSWI9EgXSxdH;4bYNqfHliYYPzZZk> M4TTTmlEPTBiPTCxPU4zPiEQvF2= Mkf2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2NkGzNVgoRjJ3NE[xN|E5RC:jPh?=
A549 NH;uS2lEgXSxdH;4bYNqfHliYYPzZZk> M3jKemlEPTBiPTCxPU42PCEQvF2= MmP3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzNkKxNlMoRjJ5MU[yNVI{RC:jPh?=
SH-SY5Y MUDDfZRwfG:6aXPpeJkh[XO|YYm= MkDMTWM2OCB;IEG5MlU1KM7:TR?= M4nEZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEexPVA6Lz5{M{i3NVkxQTxxYU6=
MGC803 NV3UepRLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MV\JR|UxKD1iMUmuPVIh|ryP NFe3U4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGwN|g4Oyd-MkmxNFM5PzN:L3G+
EKVX NXLZd4dzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3yx[3RIUSB;IEG5Mlk2KM7:TR?= M1\5UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEi4NFg3Lz5{OEC4PFA5PjxxYU6=
OVCAR5 NYnlUGFqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MW\US2khRSB{MDFOwG0> M4HYcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEG3OVQ6Lz5{N{CxO|U1QTxxYU6=
UACC62 MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MkThUGM2OCB;IEKwJO69VQ>? NHLUdGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
UACC257 NHHoZ2hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Ml20UGM2OCB;IEKwJO69VQ>? NIPwVmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxO|U1QSd-MkewNVc2PDl:L3G+
MDA-MB-231 NWPReI0xSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MkfoUGM2OCB;IEKwJO69VQ>? NWfOW5ZURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVc2PDlpPkK3NFE4PTR7PD;hQi=>
U87 MYLDfZRwfG:6aXPpeJkh[XO|YYm= M{XQcmlEPTBiPTCyNU4xPyEQvF2= MlS4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2M{W0O|koRjJyNEO1OFc6RC:jPh?=
EJ M3rsOGN6fG:2b4jpZ4l1gSCjc4PhfS=> MV\JR|UxKD1iMkKuPUDPxE1? MnSyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MEC5NlAoRjJ2M{CwPVIxRC:jPh?=
HCT116 NEjTeo5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MoDuTWM2OCB;IEKzMlMyKM7:TR?= M1fsWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkCyOlc1Lz5{OU[wNlY4PDxxYU6=
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Assay
Methods Test Index PMID
Western blot LC3-I / LC-3II / ATG5 ; p-STAT3 / STAT3 / Mcl-1 ; β-catenin / Survivin / Mcl-1 / PTMA ; pERK / ERK ; p-PKM2(y105) / PMK2 / Caspase-9 ; RET(pY1016) / VEGFR2(pY1214) / MEK1(pT292) / ERK(pY204) ; Cyclin D1 23392173 26517516 22286758 26959741 22941289 26039995
Growth inhibition assay Cell viability 26039995
Immunofluorescence p65 ; cytochrome c 22286758 22278289
ELISA TGF-beta / CD206 ; Caspase-9 / Caspase-3 26158762 30923462
In vivo Oral administration of Sorafenib (~60 mg/kg) demonstrates broad spectrum, dose-dependent anti-tumor activity against a variety of human tumor xenograft models including MDA-MB-231, Colo-205, HT-29, DLD-1, NCI-H460, and A549, with no evidence of toxicity. In association with the anti-tumor efficacy, Sorafenib treatment potently inhibits MEK 1/2 phosphorylation and pERK 1/2 levels in HT-29 and MDA-MB-231 xenografts but not in Colo-205 xenografts, and significantly suppresses tumor microvessel area (MVA) and microvessel density (MVD) in MDA MB-231, HT-29 and Colo-205 tumor xenografts. [1] Sorafenib treatment produces dose-dependent growth inhibition of PLC/PRF/5 tumor xenografts in SCID mice with TGIs of 49% and 78% at 10 mg/kg and 30 mg/kg, respectively, consistent with the inhibition of ERK and eIF4E phosphorylation, reduction of the microvessel area, and induction of tumor cell apoptosis. [2] Sorafenib sensitizes bax-/- cells to TRAIL in a dose-dependent manner, through a mechanism involving down-regulating NF-κB mediated Mcl-1 and cIAP2 expression. Combining Sorafenib (30-60 mg/kg) with TRAIL (5 mg/kg) show dramatic efficacy in TRAIL-resistant HCT116 bax-/- and HT29 tumor xenografts. [3]

Protocol (from reference)

Kinase Assay:

[1]

  • Biochemical assays:

    Recombinant baculoviruses expressing Raf-1 (residues 305–648) and B-Raf (residues 409–765) are purified as fusion proteins. Full-length human MEK-1 is generated by PCR and purified as a fusion protein from Escherichia coli lysates. Sorafenib tosylate is added to a mixture of Raf-1 (80 ng), or B-Raf (80 ng) with MEK-1 (1 μg) in assay buffer [20 mM Tris (pH 8.2), 100 mM NaCl, 5 mM MgCl2, and 0.15% β-mercaptoethanol] at a final concentration of 1% DMSO. The Raf kinase assay (final volume of 50 μL) is initiated by adding 25 μL of 10 μM γ[33P]ATP (400 Ci/mol) and incubated at 32 °C for 25 minutes. Phosphorylated MEK-1 is harvested by filtration onto a phosphocellulose mat, and 1% phosphoric acid is used to wash away unbound radioactivity. After drying by microwave heating, a β-plate counter is used to quantify filter-bound radioactivity. Human VEGFR2 (KDR) kinase domain is expressed and purified from Sf9 lysates. Time-resolved fluorescence energy transfer assays for VEGFR2 are performed in 96-well opaque plates in the time-resolved fluorescence energy transfer format. Final reaction conditions are as follows: 1 to 10 μM ATP, 25 nM poly GT-biotin, 2 nM Europium-labeled phospho (p)-Tyr antibody (PY20), 10 nM APC, 1 to 7 nM cytoplasmic kinase domain in final concentrations of 1% DMSO, 50 mM HEPES (pH 7.5), 10 mM MgCl2, 0.1 mM EDTA, 0.015% Brij-35, 0.1 mg/mL BSA, and 0.1% β-mercaptoethanol. Reaction volumes are 100 μL and are initiated by addition of enzyme. Plates are read at both 615 and 665 nM on a Perkin-Elmer VictorV Multilabel counter at ~1.5 to 2.0 hours after reaction initiation. Signal is calculated as a ratio: (665 nm/615 nM) × 10,000 for each well. For IC50 generation, Sorafenib tosylate is added before the enzyme initiation. A 50-fold stock plate is made with Sorafenib tosylate serially diluted 1:3 in a 50% DMSO/50% distilled water solution. Final Sorafenib tosylate concentrations range from 10 μM to 4.56 nM in 1% DMSO.

Cell Research:

[1]

  • Cell lines: MDA-MB-231, and HAoSMC
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 72 hours
  • Method:

    Cells are exposed to increasing concentrations of Sorafenib tosylate for 72 hours. Cell number is quantitated using the Cell TiterGlo ATP Luminescent assay kit. This assay measures the number of viable cells per well by measurement of luminescent signal based on amount of cellular ATP.

Animal Research:

[1]

  • Animal Models: Female NCr-nu/nu mice implanted s.c. with MDA-MB-231, Colo-205, HT-29, H460, or A549 cells
  • Dosages: ~60 mg/kg
  • Administration: Orally once daily

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
5%DMSO+45%PEG400+50%H2O
For best results, use promptly after mixing.

0.375mg/mL

Chemical Information

Molecular Weight 464.82
Formula

C21H16ClF3N4O3

CAS No. 284461-73-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

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Working concentration: mg/ml;

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05068752 Recruiting Drug: Vemurafenib|Drug: Sorafenib Pancreas Cancer HonorHealth Research Institute|Bayer|Genentech Inc. October 28 2021 Phase 2
NCT04763408 Recruiting Drug: Lenvatinib|Drug: Sorafenib Carcinoma Hepatocellular Eisai Inc. April 9 2021 --
NCT04000737 Recruiting Drug: YIV-906+Sorafenib|Drug: Placebo+Sorafenib Advanced Hepatocellular Carcinoma Yiviva Inc. January 10 2020 Phase 2
NCT03958669 Recruiting -- Hepatocellular Carcinoma|Sorafenib University Hospital Tuebingen|German Federal Ministry of Education and Research November 1 2019 --
NCT03764293 Active not recruiting Drug: SHR-1210|Drug: Apatinib|Drug: Sorafenib Locally Advanced or Metastatic and Unresectable HCC Jiangsu HengRui Medicine Co. Ltd. June 10 2019 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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