Solifenacin (YM905)

Catalog No.S5238

For research use only.

Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.

Solifenacin (YM905) Chemical Structure

CAS No. 242478-37-1

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Biological Activity

Description Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 72 mg/mL
(198.64 mM)


Chemical Information

Molecular Weight 362.46
Formula

C23H26N2O2

CAS No. 242478-37-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CN2CCC1C(C2)OC(=O)N3CCC4=CC=CC=C4C3C5=CC=CC=C5

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05040984 Recruiting Drug: Solifenacin Oral Tablet|Drug: Mirabegron 25mg Overactive Bladder Syndrome Far Eastern Memorial Hospital April 30 2021 --
NCT04693897 Not yet recruiting Drug: Mirabegron 50 MG|Drug: Solifenacin Succinate 5 MG Overactive Bladder Syndrome|Detrusor Overactivity Chang Gung Memorial Hospital March 1 2021 --
NCT02940314 Completed Drug: HIP1503|Drug: HGP1103 Overactive Bladder Hanmi Pharmaceutical Company Limited March 2016 Phase 1
NCT02127034 Completed Drug: Mirabegron|Drug: Solifenacin|Drug: Digoxin Healthy Subjects|Pharmacokinetics|Drug-Drug Interaction (DDI) Astellas Pharma Europe B.V.|Astellas Pharma Inc March 2014 Phase 1
NCT01880619 Completed Drug: Tamsulosin|Drug: Solifenacin|Drug: Control Relieve of Ureteral Stent Symptoms Mansoura University January 2013 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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