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Solifenacin (YM905)

Name: Solifenacin (YM905)
Brand: Selleck Chemicals
SKU: S5238
Rating: 5 (0 reviews)

Catalog No.S5238

For research use only.

Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.

CAS No. 242478-37-1

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Biological Activity

Description	Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.

Protocol (from reference)

Solubility (25°C)

In vitro	DMSO	72 mg/mL (198.64 mM)

Chemical Information

Molecular Weight	362.46
Formula	C₂₃H₂₆N₂O₂
CAS No.	242478-37-1
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	C1CN2CCC1C(C2)OC(=O)N3CCC4=CC=CC=C4C3C5=CC=CC=C5

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Clinical Trial Information

NCT Number	Recruitment	Interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05040984	Recruiting	Drug: Solifenacin Oral Tablet\|Drug: Mirabegron 25mg	Overactive Bladder Syndrome	Far Eastern Memorial Hospital	April 30 2021	--
NCT04693897	Not yet recruiting	Drug: Mirabegron 50 MG\|Drug: Solifenacin Succinate 5 MG	Overactive Bladder Syndrome\|Detrusor Overactivity	Chang Gung Memorial Hospital	March 1 2021	--
NCT02940314	Completed	Drug: HIP1503\|Drug: HGP1103	Overactive Bladder	Hanmi Pharmaceutical Company Limited	March 2016	Phase 1
NCT02127034	Completed	Drug: Mirabegron\|Drug: Solifenacin\|Drug: Digoxin	Healthy Subjects\|Pharmacokinetics\|Drug-Drug Interaction (DDI)	Astellas Pharma Europe B.V.\|Astellas Pharma Inc	March 2014	Phase 1
NCT01880619	Completed	Drug: Tamsulosin\|Drug: Solifenacin\|Drug: Control	Relieve of Ureteral Stent Symptoms	Mansoura University	January 2013	Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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