Selisistat (EX 527)

Catalog No.S1541 Synonyms: SEN0014196

For research use only.

Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.

Selisistat (EX 527) Chemical Structure

CAS No. 49843-98-3

Selleck's Selisistat (EX 527) has been cited by 218 publications

Purity & Quality Control

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Biological Activity

Description Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.
Features Greater potency, specificity, stability, and lower toxicity than other inhibitors of SIRT1 catalytic activity identified to date.
Targets
SIRT1 [1]
(Cell-free assay)
38 nM
In vitro

EX 527 exhibits potently inhibitory effect against SIRT1 deacetylase activity in a concentration-dependent manner with an IC50 of 38 nM, displays much lower activity against SIRT2 and SIRT3 with IC50 values of 19.6 μM and 48.7 μM, respectively. EX 527 does not inhibit SIRT4-7 and class I/II HDAC activity at concentrations up to 100 μM. EX-527 alone (1 μM) has no detectable effect on the acetylation of p53 lysine 382 in NCI-H460 cells. EX-527 significantly increases the amount of acetylated p53 in NCI-H460 cells, human mammary epithelial cells, U-2 OS and MCF-7 cells subjected to genotoxic agents such as Etoposide, Doxorubicin, Hydroxyurea, and Hydrogen peroxide, which is more effective than that caused by Nicotinamide (5 mM). But surprisingly EX 527 does not result in detectable effects on p53-controled gene expression, cell survival, or cell proliferation. [1] EX 527 causes a 90% increase in cell number of HCT116 cells after 7 days in the condition of 0.1% serum but not 10% serum, suggesting that SIRT1 is a significant regulator of cell proliferation during growth factor deprivation conditions. [2] EX 527 abrogates resveratrol effects on glucose responses, and prevents resveratrol-induced up-regulation of Glut2, glucokinase, Pdx-1, and Tfam in INS-1E Cells, due to the opposite effect of EX 527 and resveratrol on SIRT1 deacetylase activity. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Platelets MW\BdI9xfG:|aYOgRZN{[Xl? NIrC[mUyOC93MDFOwG0> NWCxb5JwOTBibXnu MVfEUXNQ M17qN4lv[3KnYYPld{BTV1NibHX2[YwhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh{OUS5OUc,OjV6Mkm0PVU9N2F-
HEK 293 MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfXNlQhcA>? NFy1SIlKSzVyPUm3MlchyrFiOD6xJO69VQ>? Mo\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7OUi0NlcoRjJ2OUm4OFI4RC:jPh?=
HeLa Ml;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HWR|I1KGh? NGLrXWZKSzVyPUO3MlnDqMLzwrCxMlgh|ryP NIr1V4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm5PFQzPyd-MkS5PVg1Ojd:L3G+
HEK 293 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInUUYs1QCCq M{XtfWlEPTB;NkmuNOKhyrIEoECuO{DPxE1? MlTTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7OUi0NlcoRjJ2OUm4OFI4RC:jPh?=
HeLa NYHtdVBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfKb5pLPDhiaB?= NGi1eHpKSzVyPUiuPeKhyrIEoEGuPUDPxE1? NGnHSYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm5PFQzPyd-MkS5PVg1Ojd:L3G+
RMECs NYD1PG5vSXCxcITvd4l{KEG|c3H5 NH7WdWkyOMLizszN MXeyOOKhcA>? NVz0UZVw[XS2ZX71ZZRmeyC2aHWgZY51cS2jcH;weI91cWNiZX\m[YN1KG:oIFTld{1I NUjtRpZ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0PFYyPDdpPkK0OFg3OTR5PD;hQi=>
HUVECs MV;BdI9xfG:|aYOgRZN{[Xl? Ml3YNVDDqM7:TR?= NHnGSWgzPCCq Mo\3Zo9tcXOqZYOgeIhmKHC{b4TlZ5RqfmViZX\m[YN1KG:oIILld5ZmemG2cn;sJIlvKGOnbHygeoli[mmuaYT5 MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN3OEmyPEc,OjN|NUi5Nlg9N2F-
K562 MYfGeY5kfGmxbjDBd5NigQ>? Ml;RNE4yNTFizszN MmjMNkBp Mki1d5RqdXWuYYTld{BPemZ{LXTldIVv\GWwdDDn[Y5mKHS{YX7zZ5JqeHSrb36= M2j4NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUm2OFk4Lz5{MUG5OlQ6PzxxYU6=
INS-1E NHXJVppHfW6ldHnvckBCe3OjeR?= NUXhS3FEOSEQvH2= NETtSYkzPCCq Mon4dJJmfmWwdIOgdoV{fmW{YYTyc4wucW6mdXPl[EB2eC2{ZXf1cIF1cW:wIH;mxsBIdHW2Mjyg[4x2[2:taX7hd4UtWGS6LUGsJIFv\MLiVH\hcS=> NGjEWGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG2N|k1Pid-MkGxOlM6PDZ:L3G+
MCF-7  NX[ybYcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFL0OoYxNTFyMDFOwG0> Mnv2NlQwPDhxN{KgbC=> MYDEUXNQ MUTy[ZBz\XO|ZYOgZ4VtdCCycn;sbYZmemG2aX;uJIF1KHSqZTDjc45k\W62cnH0bY9vKOLLpUGwNEDPxE1? M4XrU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{exO|A6Lz5{MEO3NVcxQTxxYU6=
NCI-H460  M3jUZWZ2dmO2aX;uJGF{e2G7 NIr3WGMyKM7:bR?= M4T0fFYhcA>? MmHuSG1UVw>? MoPXdJJw\HWlZYOgZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDpcoNz\WG|ZTDpckB1cGViYX3veY51KG:oIHHj[ZR6dGG2ZXSgdFU{ MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjN3NE[3O{c,OTZ|NUS2O|c9N2F-
293T NIfKW3FHfW6ldHnvckBie3OjeR?= M4\CWGlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiR2PUMZRi\2enZDDTTXJVOSCneIDy[ZN{\WRiaX6gNlk{XCClZXzsd{BjgSCIbIXvdkBl\SCOeYOg[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyIE2gNE4xOzhizszNMi=> NVvkd|N3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzNFY6ODZpPkKxN|A3QTB4PD;hQi=>
Escherichia coli cells M{DM[WZ2dmO2aX;uJIF{e2G7 NIrjPHJKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGPJVnQyKGW6cILld5Nm\CCrbjDFd4Np\XKrY3jpZUBkd2yrIHPlcIx{KHW|aX7nJIFk\XS7bHH0[YQhVHm|IIPp[IUh[2ijaX6gZY1qdm9iYXPp[JMhOzd7LUO4NkApSXKpLVjpd{1NgXNvTInzLGFkMSlicEWzJINwdmq3Z3H0[YQhf2m2aDDhcYlvd22ndHj5cINwfW2jcnnuJIF{KHO3YoP0doF1\SCkeTDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTBiPTCwMlE3KM7:TT6= M3vvPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUOxOVI3Lz5{MkmzNVUzPjxxYU6=
BL21 (DE3) M{Trc2Z2dmO2aX;uJIF{e2G7 M2LjfmlvcGmkaYTpc44hd2ZiZoXscEBt\W6pdHigbJVu[W5iU1nSWFEh\XiycnXzd4VlKGmwIFXzZ4hmemmlaHnhJINwdGliQlyyNUApTEV|KTDj[YxteyC3c3nu[{BndHWxcn;n[Y5q[yB5LXHtbY5wNTRvbXX0bJlt[2:3bXHybY4hMEGPQzmtcIFj\WynZDDw[ZB1cWSnIHL5JIZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFAvOjFizszNMi=> NYXuT5N4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyO|U5OjRpPkK1Nlc2QDJ2PD;hQi=>
Namalwa cells MUTGeY5kfGmxbjDhd5NigQ>? NV3m[Xd2OyCqcoO= NFT5bIhKdmirYnn0bY9vKG:oIGPJVnQyNW2nZHnheIVlKGWwZH;n[Y5wfXNicEWzJIRm[WOndInsZZNmKGGldHn2bZR6KGmwIHj1cYFvKE6jbXHse4Eh[2WubIOgZZN{\XO|ZXSgZZMh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BmdmijbnPlJJA2OyCmZXHj[ZR6dGG2aX;uJJRwKHS5aXPlJJRp\SCkYYPhcEBt\X[nbDDh[pRmeiB|IHjyd{BjgSCHTFnTRUwhUU6KIE2gNE43KM7:TT6= NWG3RnU3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5O|E4PjlpPkK1PVcyPzZ7PD;hQi=>
BL21 (DE3) Mki5SpVv[3Srb36gZZN{[Xl? NGO2fJBKdmirYnn0bY9vKG:oIH\1cIwhdGWwZ4ToJIh2dWGwIGPJVnQzKGW6cILld5Nm\CCrbjDFd4Np\XKrY3jpZUBkd2yrIFLMNlEhMESHMzmgZ4VtdHNidYPpcoch\my3b4Lv[4VvcWNiNz3hcYlvdy12LX3leIh6dGOxdX3hdolvKCiDTVOpMYxi[mWuZXSgdIVxfGmmZTDifUBndHWxcnXzZ4Vv[2ViYYPzZZktKEmFNUCgQUAyNjl2IN88UU4> NYn4VFJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyO|U5OjRpPkK1Nlc2QDJ2PD;hQi=>
Escherichia coli cells MmfhSpVv[3Srb36gZZN{[Xl? MXTJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFOLUmSyJIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKGOnbHzzJJV{cW6pIHHj[ZR6dGG2ZXSgUJl{KHOrZHWgZ4hicW5iYX3pco8h[WOrZIOgN|c6NTN6MjCoRZJoNUircz3MfZMuVHm|KFHjLUkheDV|IHPvcop2\2G2ZXSge4l1cCCjbXnuc41mfGi7bHPveY1iemmwIHHzJJN2[nO2cnH0[UBjgSCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVAhRSB2OD61JO69VS5? NULOe2w{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5N|E2OjZpPkKyPVMyPTJ4PD;hQi=>
A673 MY\xTHRUKGG|c3H5 MUfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSTZ5MzDj[Yxtew>? NYf1bFZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
SK-N-MC M3zONZFJXFNiYYPzZZk> Mlv3dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO= NWjje5IzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
Hs683 MkXsR4VtdCCleXPs[UBie3OjeR?= MnfSNlQhfG9iNEigbJJ{ NEj6VZpE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBJezZ6MzDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{GgdIhie2ViYYSgTWM2OCCjZoTldkAzPCC2bzC0PEBpenNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZz3iZZNm\CCobH;3JIN6fG:vZYTyfS=> MojEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2N{WzN|AoRjJ6NEe1N|MxRC:jPh?=
HCT116 MmfpSpVv[3Srb36gZZN{[Xl? NVrMTI92OTBidV2= NITVUlY5KGi{cx?= NFKzOlNKdmirYnn0bY9vKG:oIGPJVnQyKGmwIHj1cYFvKEiFVEGxOkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3X0fYxifGWmIIC1N{BifCBzMDD1UUBi\nSncjC4JIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> NYT5coE4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2OFI{ODBpPkKyOlQzOzByPD;hQi=>
NCI-H460 MoXQSpVv[3Srb36gZZN{[Xl? MYO2JIhzew>? M1v3SWlvcGmkaYTpc44hd2ZiU1nSWE0zKGmwIHj1cYFvKE6FST3IOFYxKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdFU{KGSnYXPleJlt[XSrb36gZYZ1\XJiNjDodpMh[nliaX3teY5weHKnY3nwbZRifGmxbj;pcY12dm:kbH;0eIlv\yCjbnHsfZNqeyxiSVO1NEA:KDFizszNMi=> M1LXfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzODNzMT:nQmNpTU2ETEyvZV4>
Assay
Methods Test Index PMID
Western blot GRP78 / FASL / Bcl-2 / LC3 ; Ac-H3K9 / Fibronectin / Collagen 1 / α-SMA ; PCNA / Cyclin D1 / Cyclin E ; pEGFR / EGFR / pPDGFRβ / PDGFRβ ; pSTAT3 / STAT3 ; p27 ; FOXO3a / SIRT1 / Ac-p53 / p16(INK4a) 29312612 24833701 25143434 31223423
Immunofluorescence p-p38 26824501
Growth inhibition assay Cell viability 24484175
In vivo Administration of EX 527 (~10 μg) to rats increases hypothalamic acetyl-p53 levels by inhibiting hypothalamic SIRT1 activity. Co-administration of EX 527 with ghrelin markedly blunts the orexigenic action of ghrelin by decreasing the pAMPK levels, increasing the ACC levels, and abolishing the higher expression of the transcription factors FoxO1, pCREB, and Bsx and the neuropeptides NPY and AgRP in the hypothalamic arcuate nucleus. [4]

Protocol (from reference)

Kinase Assay:[1]
  • Inhibition of GST-SIRT1 deacetylase activity:

    293T cells are transiently transfected with GST-tagged human SIRT1 in the pDEST27 Gateway vector using FuGENE-6. After 48 hours, the cells are lysed with 50 mM Tris, pH 8.0, 120 mM NaCl, 1 mM EDTA, and 0.5% Nonidet P-40, supplemented with Complete Mini protease inhibitor cocktail tablets. GST-SIRT1 is purified from lysates using glutathione-Sepharose beads and washed extensively in the above buffer. The deacetylation assay is performed with approximately 30 ng of GST-SIRT1 in the presence of EX 527 (48 pM to 100 μM). Deacetylation is measured using the Fluor de Lys kit using a fluorogenic peptide encompassing residues 379 to 382 of p53, acetylated on lysine 382. The acetylated lysine residue is coupled to an aminomethylcoumarin moiety. The peptide is deacetylated by SIRT1, followed by the addition of a proteolytic developer that releases the fluorescent aminomethylcoumarin. Briefly, enzyme preparations are incubated with 170 μM NAD+ and 100 μM p53 fluorogenic peptide for 45 minutes at 37 °C followed by incubation in developer for 15 minutes at 37 °C. Fluorescence is measured by excitation at 360 nm and emission at 460 nm and enzymatic activity is expressed in relative fluorescence units.

Cell Research:[1]
  • Cell lines: NCI-H460, MCF-7, U-2 OS and HMEC
  • Concentrations: Dissolved in DMSO, final concentration 1 μM
  • Incubation Time: 48 or 72 hours
  • Method: For viability assays, cells are treated with EX 527 for 48 hours. Cell viability is then determined using the Cell Titer-Glo luminescent assay, which measures total ATP level as an index of cell number. Luminescence is measured on a Luminoskan Ascent. For the proliferation assay, 0.5 μCi/mL of [14C]thymidine is added to the medium immediately after EX 527. Plates are counted at 48 hours (HMEC) or 72 hours (NCI-H460, MCF-7, and U-2 OS cells) in a Microbeta liquid scintillation counter. Thymidine incorporated by the cells is detected by proximity to the scintillant in the base of the Cytostar-T tissue culture plate.
  • (Only for Reference)
Animal Research:[4]
  • Animal Models: Male Sprague-Dawley rats
  • Dosages: ~5 μg/rat
  • Administration: Intracerebroventricular injection
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 49 mg/mL
(197.01 mM)
Ethanol 18 mg/mL
(72.37 mM)
Water Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.

15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 248.71
Formula

C13H13ClN2O

CAS No. 49843-98-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01485965 Completed Drug: SEN0014196 Huntington''s Disease Siena Biotech S.p.A. November 2011 Phase 1
NCT01521832 Completed Drug: SEN0014196 Huntington''s Disease Siena Biotech S.p.A. October 2009 Phase 1

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
what is the extinction coefficient of S1541 WX527?

Answer:
The extinction coefficient of S1541 EX-527 is 1421.650635.

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