Smurf1-IN-A01

Catalog No.S0345 Synonyms: A01, SMURF1 inhibitor A01

For research use only.

Smurf1-IN-A01 can inhibit Smurf1-mediated Smad1/5 degradation and accelerate BMP-2 signal responsiveness with a Kd of 3.664 nM.

Smurf1-IN-A01 Chemical Structure

CAS No. 1007647-73-5

Purity & Quality Control

Choose Selective E3 Ligase Inhibitors

Biological Activity

Description Smurf1-IN-A01 can inhibit Smurf1-mediated Smad1/5 degradation and accelerate BMP-2 signal responsiveness with a Kd of 3.664 nM.
Targets
Smurf1 [1]
3.664 nM(Kd)

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 512.93
Formula

C22H20ClF3N4O3S

CAS No. 1007647-73-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC=NN1C2=CC=C(C=C2)C(=O)N3CCN(CC3)S(=O)(=O)C4=CC(=C(C=C4)Cl)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05139121 Recruiting Drug: MR-100A-01 Contraception Mylan Technologies Inc.|Mylan Inc.|Viatris Inc. October 26 2021 Phase 3
NCT04012242 Recruiting Diagnostic Test: Ultrasound application Nonalcoholic Steatohepatitis|Ultrasound|Elastography Tokyo Medical University June 15 2019 --
NCT01357993 Completed Drug: JNS001 Attention-Deficit / Hyperactivity Disorder Janssen Pharmaceutical K.K. May 2011 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-11-29)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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