SB366791

For research use only.

Catalog No.S8238

1 publication

SB366791 Chemical Structure

Molecular Weight(MW): 287.74

SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist with an IC50 of 5.7 nM.

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Selleck's SB366791 has been cited by 1 publication

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Choose Selective TRP Channel Inhibitors

Biological Activity

Description SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist with an IC50 of 5.7 nM.
Targets
TRPV1 [1]
(Cell-based assay)
5.7 nM
In vitro

SB-366791 is a structurally novel and potent TRPV1 antagonist which is capable of inhibiting the capsaicin-, acid- and heat-mediated activation of the receptor but produces little or no effect on a wide range of enzymes, ion channels, GPCRs and other proteins. SB-366791 may prove to be a better tool for unambiguously defining the (patho)physiological role of TRPV1[1].

In vivo the TRPV1 antagonist SB366791 reduces the number of flinches but did not improve ambulation and weight-bearing. A sub-analgesic dose of SB366791 potentiates the effects of morphine at doses of 3.0 and 10.0 mg/kg on flinches and weight-bearing but not ambulation. The combination of morphine and SB366791 has potent analgesic effects on bone cancer pain[2].

Protocol

Cell Research:[3]
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  • Cell lines: Gingival epithelial cells(epi 4)
  • Concentrations: 1 μM
  • Incubation Time: 30 min
  • Method: Pretreatment with the TRPV1 antagonist, SB-366791 (1 µM), for 30 min inhibited capsaicin-induced cell proliferation at 72 hr.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: Adult male C3H/HeJ mice
  • Dosages: 0.1, 0.3 and 1.0 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 57 mg/mL (198.09 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 287.74
Formula

C16H14ClNO2

CAS No. 472981-92-3
Storage powder
in solvent
Synonyms N/A
Smiles COC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(Cl)C=C2

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID