Home Transmembrane Transporters TRP Channel antagonist SB366791 For research use only.

SB366791

SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist with an IC50 of 5.7 nM.

SB366791 Chemical Structure

SB366791 Chemical Structure

CAS: 472981-92-3

Selleck's SB366791 has been cited by 1 publication

Purity & Quality Control

Batch: S823801 DMSO] 57 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.74%
99.74

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Biological Activity

Description SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist with an IC50 of 5.7 nM.
Targets
TRPV1 [1]
(Cell-based assay)
5.7 nM
In vitro
In vitro SB-366791 is a structurally novel and potent TRPV1 antagonist which is capable of inhibiting the capsaicin-, acid- and heat-mediated activation of the receptor but produces little or no effect on a wide range of enzymes, ion channels, GPCRs and other proteins. SB-366791 may prove to be a better tool for unambiguously defining the (patho)physiological role of TRPV1[1].
Cell Research Cell lines Gingival epithelial cells(epi 4)
Concentrations 1 μM
Incubation Time 30 min
Method Pretreatment with the TRPV1 antagonist, SB-366791 (1 µM), for 30 min inhibited capsaicin-induced cell proliferation at 72 hr.
In Vivo
In vivo the TRPV1 antagonist SB366791 reduces the number of flinches but did not improve ambulation and weight-bearing. A sub-analgesic dose of SB366791 potentiates the effects of morphine at doses of 3.0 and 10.0 mg/kg on flinches and weight-bearing but not ambulation. The combination of morphine and SB366791 has potent analgesic effects on bone cancer pain[2].
Animal Research Animal Models Adult male C3H/HeJ mice
Dosages 0.1, 0.3 and 1.0 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 287.74 Formula

C16H14ClNO2
CAS No. 472981-92-3 SDF Download SB366791 SDF
Smiles COC1=CC=CC(=C1)NC(=O)C=CC2=CC=C(C=C2)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 57 mg/mL ( (198.09 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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