Silmitasertib (CX-4945) sodium salt

For research use only.

Catalog No.S0707

44 publications

Silmitasertib (CX-4945) sodium salt Chemical Structure

CAS No. 1309357-15-0

Silmitasertib (CX-4945) sodium salt is a potent, orally bioavailable and selective inhibitor of casein kinase 2 (CK2) with IC50 of 1 nM against CK2α and CK2α'.

Selleck's Silmitasertib (CX-4945) sodium salt has been cited by 44 publications

Purity & Quality Control

Choose Selective Casein Kinase Inhibitors

Biological Activity

Description Silmitasertib (CX-4945) sodium salt is a potent, orally bioavailable and selective inhibitor of casein kinase 2 (CK2) with IC50 of 1 nM against CK2α and CK2α'.
Targets
CK2α [1]
(Cell-free assay)
CK2α' [1]
(Cell-free assay)
1 nM 1 nM
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Jurkat Mn;pSpVv[3Srb36gZZN{[Xl? MULJcohq[mm2aX;uJI9nKEONMjDpckBpfW2jbjDKeZJs[XRiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBc\2GvbXGzN3BeSVSSIHnuZ49zeG:{YYTpc44hcW62bzDzeYJ{fHKjdHWgZpkhdHWvaX7ld4NmdmOnIHHzd4F6NCCLQ{WwQVAvOc7:TR?= MnnIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzN{S0N|QoRjJzMUe0OFM1RC:jPh?=
MIAPaCa2 NVTGVY1vSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MmTwOEBl[Xm| NE\OTVZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3JRXBiS2F{IHPlcIx{KGGodHXyJFQh\GG7czDifUBidGGvYYKgZox2\SCjc4PhfUwhUUN3ME2xMlHPxE1? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF5NESzOEc,OjFzN{S0N|Q9N2F-
PC3 M1SySWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVG0JIRigXN? NFfS[mtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDh[pRmeiB2IHThfZMh[nliYXzhcYFzKGKudXWgZZN{[XluIFnDOVA:Oi5zzszN MmXLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzN{S0N|QoRjJzMUe0OFM1RC:jPh?=
HCT116 MVrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NX;MRmlRPCCmYYnz NWDu[GVwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JIFt[W2jcjDicJVmKGG|c3H5MEBKSzVyPUKuNu69VQ>? MkHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzN{S0N|QoRjJzMUe0OFM1RC:jPh?=
H1299 NYG3eZRQSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXvPUJJTPCCmYYnz MUnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEhzMkm5JINmdGy|IHHmeIVzKDRiZHH5d{BjgSCjbHHtZZIh[my3ZTDhd5NigSxiSVO1NF0zNjUQvF2= M3zyWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUe0OFM1Lz5{MUG3OFQ{PDxxYU6=
Jurkat M{O5[2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MXK0JIRigXN? NX;B[Xc1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDKeZJs[XRiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JIFt[W2jcjDicJVmKGG|c3H5MEBKSzVyPUKuOe69VQ>? Mmj2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzN{S0N|QoRjJzMUe0OFM1RC:jPh?=
A549 MYXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3jUWFQh\GG7cx?= M4PtNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2IHThfZMh[nliYXzhcYFzKGKudXWgZZN{[XluIFnDOVA:O87:TR?= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF5NESzOEc,OjFzN{S0N|Q9N2F-
A375 NHPwVVZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2HS[VQh\GG7cx?= MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF|N{WgZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KGGuYX3hdkBjdHWnIHHzd4F6NCCLQ{WwQVMvQc7:TR?= M{Htb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUe0OFM1Lz5{MUG3OFQ{PDxxYU6=
BxPC3 MnPZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mlz1OEBl[Xm| MkPJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEeGDDN{Bk\WyuczDh[pRmeiB2IHThfZMh[nliYXzhcYFzKGKudXWgZZN{[XluIFnDOVA:PC52zszN MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF5NESzOEc,OjFzN{S0N|Q9N2F-
LNCAP MWfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MVe0JIRigXN? Ml;MRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOTlPBVEBk\WyuczDh[pRmeiB2IHThfZMh[nliYXzhcYFzKGKudXWgZZN{[XluIFnDOVA:PC55zszN MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF5NESzOEc,OjFzN{S0N|Q9N2F-
K562 MUjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NXnUcYJLPCCmYYnz MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KGGuYX3hdkBjdHWnIHHzd4F6NCCLQ{WwQVUvO87:TR?= MoLWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzN{S0N|QoRjJzMUe0OFM1RC:jPh?=
MDA-MB-231 NInKTIxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVO0JIRigXN? MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JIFt[W2jcjDicJVmKGG|c3H5MEBKSzVyPU[uOO69VQ>? NGqxOGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG3OFQ{PCd-MkGxO|Q1OzR:L3G+
MCF7 NIDtXZRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NITHR5c1KGSjeYO= M1TUeGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB2IHThfZMh[nliYXzhcYFzKGKudXWgZZN{[XluIFnDOVA:QC57zszN MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF5NESzOEc,OjFzN{S0N|Q9N2F-
Hs 578T MWjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MX60JIRigXN? NYPtXXR7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDId{A2PziWIHPlcIx{KGGodHXyJFQh\GG7czDifUBidGGvYYKgZox2\SCjc4PhfUwhUUN3ME2xN{4y|ryP NV[2WpZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxO|Q1OzRpPkKxNVc1PDN2PD;hQi=>
HCT116 M3Htb2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkS3O|IhcHK| MmHvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OD13LkNOwG0> Mn;MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{m0N|MoRjJ{M{O5OFM{RC:jPh?=
MCF7 NI\HWZRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXW3NkBpenN? NWPaeHE5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;Nj61{txO NWnsNmJVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|k1OzNpPkKyN|M6PDN|PD;hQi=>
A549 NEDrfFdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MoXMO|IhcHK| MkDZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGOgZZN{[XluIFnDOVA:QC5{zszN NGTHW4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzPVQ{Oyd-MkKzN|k1OzN:L3G+
LNCAP NYLkSVV7S3m2b4TvfIlkcXS7IHHzd4F6 MkTBOEBl[Xm| NEnLfWFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNVkODUDDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA1KGSjeYOgZpkhS0ONODDt[ZRpd2RuIFnDOVA:PC53Od88US=> NFT5TFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkizNlMyPid-MkK4N|I{OTZ:L3G+
LNCAP NFrifFNCeG:ydH;zbZMh[XO|YYm= MnrVQlExKHWP MXOxJJRwKDJiZHH5dy=> NVy5dHp{UW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDMUmNCWCClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDjZZNx[XOnMzDhZ5RqfmG2aX;uJIF1KD5zMDD1UUBi\nSncjCxJJRwKDJiZHH5dy=> NFvqTnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkizNlMyPid-MkK4N|I{OTZ:L3G+
LNCAP M4\LdmZ2dmO2aX;uJIF{e2G7 MU[xNEB2VQ>? MX:xNkB1dyB{NDDodpM> NUn5dHcxUW6qaXLpeIlwdiCxZjDDT|JidHCqYTDpckBpfW2jbjDMUmNCWCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[gd5Vzfmm4aX6g[ZhxemW|c3nvckBifCBzMDD1UUBi\nSncjCxNkB1dyB{NDDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz Mn3YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6M{KzNVYoRjJ{OEOyN|E3RC:jPh?=
LNCAP NUjoVIpmTnWwY4Tpc44h[XO|YYm= MVSxJJRwKDFyIIXN Mn7wNVIhcHK| NF7LVVVKdmirYnn0bY9vKG:oIFPLNkBqdiCqdX3hckBNVkODUDDj[YxteyCjc4Pld5Nm\CCjczDhcoRzd2enbjDy[YNmeHSxcjDueYNt\WG{IITyZY5{dG:lYYTpc44h[XRiMTD0c{AyOCC3TTDh[pRmeiBzMjDodpMh[nliQXzlfIEhTmy3b4KgOFg5KHO2YXnubY5oKGKjc3XkJIZtfW:{ZYPj[Y5k\SCjc4PhfS=> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh|MkOxOkc,OjJ6M{KzNVY9N2F-
LNCAP Ml3RSpVv[3Srb36gZZN{[Xl? Mnu3NUB1dyBzMDD1US=> NH\obYwyKGSjeR?= NGPZbYZKdmirYnn0bY9vKG:oIFPLNkBqdiCqdX3hckBNVkODUDDj[YxteyCjc4Pld5Nm\CCjczDETHQudWWmaXH0[YQh[W6mcn;n[Y4hemWlZYD0c5Ih[WO2aY\heIlwdiCjdDCxJJRwKDFyIIXNJIFnfGW{IEGg[IF6KGK7IHz1Z4ln\XKjc3WgZZN{[Xl? M2PLblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEOyN|E3Lz5{MkizNlMyPjxxYU6=
LNCAP NGfvO4lHfW6ldHnvckBie3OjeR?= MUCxNEB2VQ>? MXm4JIhzew>? MlvJTY5pcWKrdHnvckBw\iCFS{KgbY4hcHWvYX6gUG5ESVBiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJIFv\HKxZ3XuJJJm[2WydH;yJIRmeGWwZHXueEBRW0FibWLORUBt\X[nbDDheEAyOCC3TTDh[pRmeiB6IHjyd{BjgSC{ZXHsJJRqdWViUFPSJIFv[Wy7c3nz M3LyPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEOyN|E3Lz5{MkizNlMyPjxxYU6=
LNCAP M4fiVWZ2dmO2aX;uJIF{e2G7 M2W5d|ExKHWP MUG4JIhzew>? NFOwN2lKdmirYnn0bY9vKG:oIFPLNkBqdiCqdX3hckBNVkODUDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yh[W6mcn;n[Y4hemWlZYD0c5Ih\GWyZX7k[Y51KFSPUGLTV|IhdVKQQTDs[ZZmdCCjdDCxNEB2VSCjZoTldkA5KGi{czDifUBz\WGuIITpcYUhWEOUIHHuZYx6e2m| MmK1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6M{KzNVYoRjJ{OEOyN|E3RC:jPh?=
LNCAP M1q1XWZ2dmO2aX;uJIF{e2G7 NFPibGMyKHSxIEGwJJVO NUTXe5dXQCCqcoO= NGO1UINKdmirYnn0bY9vKG:oIFPLNkBqdiCqdX3hckBNVkODUDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YhTEiWLXnu[JVk\WRiYX7kdo9o\W5icnXj[ZB1d3JiZHXw[Y5l\W62IGTNVHJUWzJibWLORUBmgHC{ZYPzbY9vKGG2IEGgeI8hOTBidV2gZYZ1\XJiODDodpMh[nlicnXhcEB1cW2nIGDDVkBidmGueYPpdy=> NFTReG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkizNlMyPid-MkK4N|I{OTZ:L3G+
LNCAP NXPSR3BCTnWwY4Tpc44h[XO|YYm= M{TNNVMhfU1? NFvEfJE5KGi{cx?= MWjJcohq[mm2aX;uJI9nKEONMjDpckBpfW2jbjDMUmNCWCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[gZY5lem:pZX6gdoVk\XC2b4Kg[IVx\W6mZX70JGRJXC2rbnT1Z4VlKFCVQTDtVm5CKGW6cILld5Nqd25iYYSgN{B2VSCjZoTldkA5KGi{czDifUBz\WGuIITpcYUhWEOUIHHuZYx6e2m| NUe4TIR3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4N|I{OTZpPkKyPFMzOzF4PD;hQi=>
LNCAP NXLT[2hUTnWwY4Tpc44h[XO|YYm= NHnENHIyOCC3TR?= NHTCdVYyOiC2bzCyOEBpenN? NXzse5NEUW6qaXLpeIlwdiCxZjDDT|IhcW5iaIXtZY4hVE6FQWCgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKGGwZILv[4VvKHKnY3XweI9zKG63Y3zlZZIhfHKjboPsc4NifGmxbjDheEAyOCC3TTDh[pRmeiBzMjD0c{AzPCCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| MmfyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6M{KzNVYoRjJ{OEOyN|E3RC:jPh?=
LNCAP Mnf5RZBweHSxc3nzJIF{e2G7 M1y3XVMxKHWP Mk\YO|IhcHK| M3OxcWlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTF7DRXAh[2WubIOgZZQhOzBidV2gZYZ1\XJiN{KgbJJ{KGK7IFHucoV5cW6YIIP0ZYlvcW6pIHLhd4VlKG[udX;y[ZNk\W62IH3pZ5Jwe2OxcIm= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh|MkOxOkc,OjJ6M{KzNVY9N2F-
LNCAP NFzqT2lHfW6ldHnvckBie3OjeR?= MXyxNEB2VQ>? NFnwe5cyOiC2bzCyOEBpenN? M3fzb2Rwf26{ZXf1cIF1cW:wIH;mJGNMOmGucHjhJIV5eHKnc4Ppc44hcW5iaIXtZY4hVE6FQWCgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKGO7dH;zc4xq[yCycn;0[YlvKGyndnXsJIF1KDFyIIXNJIFnfGW{IEGyJJRwKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh|MkOxOkc,OjJ6M{KzNVY9N2F-
LNCAP MVnGeY5kfGmxbjDhd5NigQ>? M1P6SVExKHWP M{fNd|EzKHSxIEK0JIhzew>? MWjEc5dvemWpdXzheIlwdiCxZjDDT|JidHCqYTDlfJBz\XO|aX;uJIlvKGi3bXHuJGxPS0GSIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBvfWOuZXHyJJBzd3SnaX6gcIV3\WxiYYSgNVAhfU1iYX\0[ZIhOTJidH:gNlQhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? NVXObnpwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4N|I{OTZpPkKyPFMzOzF4PD;hQi=>
LNCAP MX7GeY5kfGmxbjDhd5NigQ>? M{LWb|ExKHWP NV\mVoRGOTJidH:gNlQhcHK| NV;pUZhOUW6qaXLpeIlwdiCxZjDDT|JidHCqYTDpckBpfW2jbjDMUmNCWCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[gdFIyKHCqb4PwbI9zgWyjdHnvckBifCC2aILlc45qdmVzNEWgZZQhOTBidV2gZYZ1\XJiMUKgeI8hOjRiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NXPjVnBbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4N|I{OTZpPkKyPFMzOzF4PD;hQi=>
LNCAP M4fwVGZ2dmO2aX;uJIF{e2G7 MVyxNEB2VQ>? M{DXd|EzKHSxIEK0JIhzew>? NEf0VYZKdmirYnn0bY9vKG:oIFPLNoFteGijIHnuJIh2dWGwIFzOR2FRKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;uJIF1KFOnckS3N{BifCBzMDD1UUBi\nSncjCxNkB1dyB{NDDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz NIPLZ4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkizNlMyPid-MkK4N|I{OTZ:L3G+
LNCAP M{HhV2Z2dmO2aX;uJIF{e2G7 Mn\RNVAhfU1? M1HKVVEzKHSxIEK0JIhzew>? M33VbmlvcGmkaYTpc44hd2ZiQ1uyZYxxcGFiaX6gbJVu[W5iTF7DRXAh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIGjJRXAh\XiycnXzd4lwdiCjdDCxNEB2VSCjZoTldkAyOiC2bzCyOEBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh|MkOxOkc,OjJ6M{KzNVY9N2F-
LNCAP MkTWSpVv[3Srb36gZZN{[Xl? MVGxNEB2VQ>? M4HlXlEzKHSxIEK0JIhzew>? NEDwN5hKdmirYnn0bY9vKG:oIFPLNoFteGijIHnuJIh2dWGwIFzOR2FRKGOnbHzzJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDDTG9RKGW6cILld5Nqd25iYYSgNVAhfU1iYX\0[ZIhOTJidH:gNlQhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh|MkOxOkc,OjJ6M{KzNVY9N2F-
LNCAP MXXGeY5kfGmxbjDhd5NigQ>? MWmxNEB2VQ>? M1;wNVEzKHSxIEK0JIhzew>? M1\WNGlvcGmkaYTpc44hd2ZiQ1uyJIlvKGi3bXHuJGxPS0GSIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBidmS{b3flckBz\WOncITvdkBvfWOuZXHyJJRz[W6|bH;jZZRqd25iYYSgNVAhfU1iYX\0[ZIhOTJidH:gNlQhcHK|IHL5JGhEWyCjbnHsfZNqew>? NVGyW25jRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4N|I{OTZpPkKyPFMzOzF4PD;hQi=>
MV4-11 NVW2[pVzSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NVrkU5N3OSC2bzCzJIRigXN? M1PBZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTW[0MVEyKGOnbHzzJIFnfGW{IEGgeI8hOyCmYYnzJIJ6KE2WUzDhd5NigSxiQ1O1NF0{|ryP MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzdzMUizNkc,OjN5MUG4N|I9N2F-
U937 M2XyfmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NELld2QyKHSxIEOg[IF6ew>? NVfFV3NrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPVM4KGOnbHzzJIFnfGW{IEGgeI8hOyCmYYnzJIJ6KE2WUzDhd5NigSxiQ1O1NF01NjMQvF2= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzdzMUizNkc,OjN5MUG4N|I9N2F-
Jurkat NFmxXZNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NYTCcmZrOSC2bzCzJIRigXN? NVzkbmJ5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDKeZJs[XRiY3XscJMh[W[2ZYKgNUB1dyB|IHThfZMh[nliTWTTJIF{e2G7LDDDR|UxRTRwNd88US=> MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzdzMUizNkc,OjN5MUG4N|I9N2F-
K562 NHLFV5lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVWxJJRwKDNiZHH5dy=> MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhOSC2bzCzJIRigXNiYomgUXRUKGG|c3H5MEBESzVyPUhOwG0> M{[xNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{GxPFMzLz5{M{exNVg{OjxxYU6=
A549 MYPGeY5kfGmxbjDhd5NigQ>? MUixNEB2VQ>? Mk\TTY5pcWKrdHnvckBw\iCFS{KtcYVlcWG2ZXSgSXJMKHCqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBCPTR7IHPlcIx{KGG2IEGwJJVOKGK7IGfld5Rmem5iYnzveEBu\XSqb3S= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzMkGyOEc,OjRyMUKxNlQ9N2F-
A549 NV;hTWgxTnWwY4Tpc44h[XO|YYm= MYqzNEB2VQ>? NV3jeZJ2PDhiaILz MYTJcohq[mm2aX;uJI9nKEONMj3t[YRq[XSnZDDNUXAzKGGldHn2ZZRqd25iaX6gbJVu[W5iQUW0PUBk\WyuczDheEA{OCC3TTDh[pRmeiB2ODDodpMh[nliZ3XsZZRqdi28eX3v[5JieGi7 NF\NZnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECxNlEzPCd-MkSwNVIyOjR:L3G+
A549 MUnGeY5kfGmxbjDhd5NigQ>? MUOxNEB2VQ>? Mnq3OEB1dyB{NDDodpM> M4rOcmlvcGmkaYTpc44hd2ZiQ1uyMY1m\GmjdHXkJGFMXCCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hSTV2OTDj[YxteyCjdDCxNEB2VSCjZoTldkA1KHSxIEK0JIhzeyCkeTDX[ZN1\XKwIHLsc5QhdWW2aH;k MmXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyMUKxNlQoRjJ2MEGyNVI1RC:jPh?=
A549 MXrGeY5kfGmxbjDhd5NigQ>? NYPSSmppOTBidV2= NXvGOYRJOTVidH:gN|AhdWmwcx?= NXLhNlNjUW6qaXLpeIlwdiCxZjDDT|IudWWmaXH0[YQhTVKNIIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCDNUS5JINmdGy|IHH0JFExKHWPIHHmeIVzKDF3IITvJFMxKG2rboOgZpkhX2W|dHXyckBjdG:2IH3leIhw\A>? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzMkGyOEc,OjRyMUKxNlQ9N2F-
A549 NX;zWlJ1TnWwY4Tpc44h[XO|YYm= MkO5NVAhfU1? NXnZR21KOjRiaILz NHnld3ZKdmirYnn0bY9vKG:oIFPLNk1u\WSrYYTl[EBCU1RicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKEF3NEmgZ4VtdHNiYYSgNVAhfU1iYX\0[ZIhOjRiaILzJIJ6KFenc4Tldo4h[myxdDDt[ZRpd2R? MmLYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyMUKxNlQoRjJ2MEGyNVI1RC:jPh?=
A549 MX;GeY5kfGmxbjDhd5NigQ>? M1zwR|EhfG9iMUCgeW0> Mnf2NlQhcHK| NXi1W3d3UW6qaXLpeIlwdiCxZjDDT|IudWWmaXH0[YQhVVRzLV3NVEBmgHC{ZYPzbY9vKGmwIHj1cYFvKEF3NEmgZ4VtdHNiYYSgNUB1dyBzMDD1UUBi\nSncjCyOEBpenNiYomgW4V{fGW{bjDicI91KG2ndHjv[C=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzMkGyOEc,OjRyMUKxNlQ9N2F-
Sf9 M1L3cGZ2dmO2aX;uJIF{e2G7 NVHqT5dNUW6qaXLpeIlwdiCxZjDDSGszN2O7Y3zpckBGKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIGPmPUBk\WyuczD1d4lv\yCqaYP0c45mKEhzIHHzJJN2[nO2cnH0[UBqdiCycnXz[Y5k\SCxZjDb[4FudWF|M2DdRXRRNCCLQ{WwQVEvQM7:TR?= M3;YclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixPVg3Lz5{NE[4NVk5PjxxYU6=
A549 M3jMUmN6fG:2b4jpZ4l1gSCjc4PhfS=> NUfJelBzPzJiaILz NUHhWpdWS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCFQ{WwQVkvQc7:TR?= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh3MEO3Okc,OjZ6NUCzO|Y9N2F-
DAOY NVnR[HFNeUiWUzDhd5NigQ>? M2X6UJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCGQV;ZJINmdGy| MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
SJ-GBM2 NUfKO2h[eUiWUzDhd5NigQ>? MXHxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0pvR1LNNkBk\Wyucx?= NXzL[5FmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
A673 NUnNN|JJeUiWUzDhd5NigQ>? NEjXTI1yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQU[3N{Bk\Wyucx?= MorYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC MkXjdWhVWyCjc4PhfS=> M2XvZpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMW1EKGOnbHzz MlTTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
BT-37 M2e3eJFJXFNiYYPzZZk> MUDxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSlRvM{egZ4VtdHN? NImw[209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
NB-EBc1 NGfZ[XJyUFSVIHHzd4F6 NH7xRm5yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKtSWJkOSClZXzsdy=> M{T1ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
U-2 OS NGPlVmRyUFSVIHHzd4F6 NHm5bZpyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiVT2yJG9UKGOnbHzz NVf1VnR{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
Saos-2 NF[4fotyUFSVIHHzd4F6 Ml3CdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFOjb4OtNkBk\Wyucx?= M2[zXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-SH NE\FOVJyUFSVIHHzd4F6 NXXOWlJxeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPLMW4uW0hiY3XscJM> NYXrU5Z4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
NB1643 MmTadWhVWyCjc4PhfS=> NXnGWnAxeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF7CNVY1OyClZXzsdy=> MmnWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
LAN-5 NIjxfW5yUFSVIHHzd4F6 M1v4e5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCOQV6tOUBk\Wyucx?= MorjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
BT-12 M{G4dpFJXFNiYYPzZZk> NIjHWVByUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQmStNVIh[2WubIO= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Rh18 MUfxTHRUKGG|c3H5 NVf2bZd3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGLoNVgh[2WubIO= NVzi[486RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
OHS-50 NITlNJJyUFSVIHHzd4F6 NWTNVIl7eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF;IV{02OCClZXzsdy=> MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
RD NHeyZWFyUFSVIHHzd4F6 Ml;pdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKGIHPlcIx{ MnyyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
MG 63 (6-TG R) MnezdWhVWyCjc4PhfS=> MkXrdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKE2JIE[zJEg3NVSJIGKpJINmdGy| NXu4bGYzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh41 NYjpTY9SeUiWUzDhd5NigQ>? NFT2co5yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUni0NUBk\Wyucx?= NHzTR5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
Sf21 insect M13o[WZ2dmO2aX;uJIF{e2G7 MXyyNEBucW6| NUXt[IdiUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDmeYxtKGynbnf0bEBPNXSncn3pcoFtKEirc{[teIFo\2WmIFPLNoFteGijIHX4dJJme3OnZDDpckBU\jJzIHnud4VkfCClZXzsd{B2e2mwZzDDT|J1cWSnIHHzJJN2[nO2cnH0[UB1emWjdHXkJIZweiB{MDDtbY5{KG2nYYP1doVlKGGodHXyJFkxKG2rboOgbY4heHKnc3XuZ4Uhd2ZiTXfDcFIh[nliY3HsbZBmeiCvb3LpcIl1gSC|aHnmeEBie3OjeTygTWM2ODxyLkCwN:69VQ>? NXfnVlBlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVkzPzhpPkK5OVU6Ojd6PD;hQi=>
786-0 NWfk[5UyTnWwY4Tpc44h[XO|YYm= NWO5c45COjRiaILz MoPjTY5pcWKrdHnvckBw\iCFS{KgbY4hcHWvYX6gO|g3NTBiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gRYt1OSCyaH;zdIhwenmuYYTpc44h[XRiU3XyNVI6KGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXNuIFnDOVA:Oc7:TR?= M2PIclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNki5PVQ3Lz5|ME[4PVk1PjxxYU6=
786-0 NXTRelg2TnWwY4Tpc44h[XO|YYm= NXvGbYZIOjRiaILz NGnDcFlKdmirYnn0bY9vKG:oIFPLNkBqdiCqdX3hckA4QDZvMDDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBidHCqYT3jZZRmdmmwIIDoc5NxcG:{eXzheIlwdiCjdDDT[ZI3PDFiYX\0[ZIhOjRiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrczygSWM2OD1zzszN MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODZ6OUm0Okc,OzB4OEm5OFY9N2F-
786-0 MV3GeY5kfGmxbjDhd5NigQ>? MlfmNlQhcHK| NIL3bI1KdmirYnn0bY9vKG:oIFPLNkBqdiCqdX3hckA4QDZvMDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hW1SDVEOgdIhwe3Cqb4L5cIF1cW:wIHH0JHk4ODViYX\0[ZIhOjRiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrczygSWM2OD13LkROwG0> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODZ6OUm0Okc,OzB4OEm5OFY9N2F-
HeLa MUPGeY5kfGmxbjDhd5NigQ>? NHPWXWE5KHWP MVGxNkBpenN? NXv4O5lkUW6qaXLpeIlwdiCHR1\QMWNMOmGucHjhJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKGi3bXHuJGhmVGFiY3XscJMhcW6mdXP0bY9vKG:oIFXHSnAuS0t{YXzwbIEhfHKjboPsc4NifGmxbjDmdo9uKG63Y3zlc4xqKHSxIH71Z4xm[XJibXH0dol5KGGwZDDjfZRweGyjc32gZZQhQCC3TTDh[pRmeiBzMjDodpMh[nliSH;lZ4h{fC1|M{O0Nk1{fGGrbnnu[{Bj[XOnZDDtbYNzd3Olb4D5 MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODZ6OUm0Okc,OzB4OEm5OFY9N2F-
Vero E6 NVjzTW1TTnWwY4Tpc44h[XO|YYm= MlLMOFghcHK| MVjJR|UxKG[xcjDhcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDTRXJUNUOxVj2yJIlvKHSqZTDW[ZJwKEV4IHPlcIwhdGmwZTDheEA1QCCqIHL5JIludXWwb3\seY9z\XOlZX7j[U1j[XOnZDDhd5NigSBqZHX0[YN1cW6pIITo[UB3cXKjbDDOVEBxem:2ZXnuJIlvKHSqZTDueYNt\XW|IH;mJJRp\SCYZYLvJGU3KGOnbHzzLUwhUUN3ME2zMlg6ODR3zszN NIj2OXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MkO1N|g2QSd-M{KzOVM5PTl:L3G+
pulmonary smooth muscle cells MXHGeY5kfGmxbjDhd5NigQ>? NFe1[ZhKdmirYnn0bY9vKG:oIHTlMYRq\m[ncnXueIlifGmxbjDv[kBpfW2jbjDweYxud26jcomgd41wd3SqIH31d4Nt\SClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ49vfHKjY4TpcIUhfG9ic4nueIhmfGmlIH\vdo1{KGOqYX7n[UwhTUN;MD6wNFHPxE1? M4D2O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzBzNkWvK|5EcEWPQly8M4E,
Jurkat T MYjGeY5kfGmxbjDhd5NigQ>? MYDNc4R2dGG2aX;uJI9nKEWwZH;n[Y5wfXNiQYPzZZk7KFSqZTDoeY1idiCuZYXr[Y1q[SCMdYLrZZQhXC2lZXzsJIxqdmVid3HzJI1icW62YXnu[YQhcW5iUmDNTUAyPjRyIDjDZY1jemW6KTDzeZBxdGWvZX70[YQhf2m2aDCxNEUh\mW2YXygZ4Ft\iC|ZYL1cUBidmRiNUCgcocwdWxiR3X1eIFugWOrbj6gRoVnd3KnIITy[YF1dWWwdDDj[YxteyC5ZYLlJJdie2inZDygdoV{fXOyZX7k[YQh[XRiYTDk[Y5{cXS7IH;mJIFjd3W2IEGwOkBk\Wyucz;tbYwtKEmFNUC9NE4y|ryP MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxOTZ3Lze+R4hGVUKOPD;hQi=>
pulmonary smooth muscle cells NVLTNFdRTnWwY4Tpc44h[XO|YYm= M13xcVEhdk1? MUPJcohq[mm2aX;uJI9nKGOjc3XpckBscW6jc3WtNk9Pc3h{LUWgbY4hcHWvYX6gdJVtdW:wYYL5JJNud2:2aDDteZNkdGViY3XscJMh[XO|ZYPz[YQh[XNiZH;3ck1z\We3bHH0bY9vKG:oIFPPUFEheHKxdHXpckBmgHC{ZYPzbY9vKGG2IEGgcm0h[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz M3nGR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzBzNkWvK|5EcEWPQly8M4E,
pulmonary smooth muscle cells MVjGeY5kfGmxbjDhd5NigQ>? MoXvNVAhdk1? MlK4TY5pcWKrdHnvckBw\iClYYPlbY4hc2mwYYPlMVIwVmu6Mj21JIlvKGi3bXHuJJB2dG2xbnHyfUB{dW:xdHigcZV{[2ynIHPlcIx{KGG|c3Xzd4VlKGG|IHTve44uemWpdXzheIlwdiCxZjDDU2wyKHC{b4TlbY4h\XiycnXzd4lwdiCjdDCxNEBvVSCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxOTZ3Lze+R4hGVUKOPD;hQi=>
pulmonary smooth muscle cells NUe2[WpQTnWwY4Tpc44h[XO|YYm= Mle1NUBvVQ>? NUPXXYdyUW6qaXLpeIlwdiCxZjDjZZNmcW5ia3nuZZNmNTJxTnv4Nk02KGmwIHj1cYFvKHC3bH3vcoFzgSC|bX;veIghdXW|Y3zlJINmdGy|IHHzd4V{e2WmIHHzJIRwf25vcnXneYxifGmxbjDv[kBES05{IIDyc5RmcW5iZYjwdoV{e2mxbjDheEAyKG6PIHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? NX\yOnNxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ|MEG2OU8oRkOqRV3CUFww[T5?
pulmonary smooth muscle cells MkW1SpVv[3Srb36gZZN{[Xl? NHP2enoyOCCwTR?= NESwUnBKdmirYnn0bY9vKG:oIHPhd4VqdiCtaX7hd4UuOi:Qa4iyMVUhcW5iaIXtZY4heHWubX;uZZJ6KHOvb3;0bEBufXOlbHWgZ4VtdHNiYYPz[ZN{\WRiYYOg[I94di2{ZXf1cIF1cW:wIH;mJGNEVjJicILveIVqdiCneIDy[ZN{cW:wIHH0JFExKG6PIHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? NI[yNHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOjNyMU[1M{c,S2iHTVLMQE9iRg>?
pulmonary smooth muscle cells NITqSY9HfW6ldHnvckBie3OjeR?= NYr2U2lIOSCwTR?= NXLRZlZ7UW6qaXLpeIlwdiCxZjDjZZNmcW5ia3nuZZNmNTJxTnv4Nk02KGmwIHj1cYFvKHC3bH3vcoFzgSC|bX;veIghdXW|Y3zlJINmdGy|IHHzd4V{e2WmIHHzJJVxNXKnZ4XsZZRqd25ib3[gRWNVSTJicILveIVqdiCneIDy[ZN{cW:wIHH0JFEhdk1iYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ NF;xUno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOjNyMU[1M{c,S2iHTVLMQE9iRg>?
pulmonary smooth muscle cells MWHGeY5kfGmxbjDhd5NigQ>? M4nnZlExKG6P MVfJcohq[mm2aX;uJI9nKGOjc3XpckBscW6jc3WtNk9Pc3h{LUWgbY4hcHWvYX6gdJVtdW:wYYL5JJNud2:2aDDteZNkdGViY3XscJMh[XO|ZYPz[YQh[XNidYCtdoVofWyjdHnvckBw\iCDQ2TBNkBxem:2ZXnuJIV5eHKnc4Ppc44h[XRiMUCgcm0h[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz MmLGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODF4NT:nQmNpTU2ETEyvZV4>
pulmonary smooth muscle cells NWDPe2hFTnWwY4Tpc44h[XO|YYm= MX[xJI5O Mnq0TY5pcWKrdHnvckBw\iClYYPlbY4hc2mwYYPlMVIwVmu6Mj21JIlvKGi3bXHuJJB2dG2xbnHyfUB{dW:xdHigcZV{[2ynIHPlcIx{KGG|c3Xzd4VlKGG|IIXwMZJm\3WuYYTpc44hd2ZiTWnINVEheHKxdHXpckBmgHC{ZYPzbY9vKGG2IEGgcm0h[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz M{LRPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzBzNkWvK|5EcEWPQly8M4E,
pulmonary smooth muscle cells MX7GeY5kfGmxbjDhd5NigQ>? MmTMNVAhdk1? MlXtTY5pcWKrdHnvckBw\iClYYPlbY4hc2mwYYPlMVIwVmu6Mj21JIlvKGi3bXHuJJB2dG2xbnHyfUB{dW:xdHigcZV{[2ynIHPlcIx{KGG|c3Xzd4VlKGG|IIXwMZJm\3WuYYTpc44hd2ZiTWnINVEheHKxdHXpckBmgHC{ZYPzbY9vKGG2IEGwJI5OKGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> NVTBe|Z{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ|MEG2OU8oRkOqRV3CUFww[T5?

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.05 mM)
Water 74 mg/mL (199.05 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.75
Formula

C19H11ClN3NaO2

CAS No. 1309357-15-0
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC(=CC(=C1)Cl)NC2=NC3=C(C=CC(=C3)C(=O)[O-])C4=C2C=CN=C4.[Na+]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04668209 Recruiting Drug: Silmitasertib Coronavirus University of Arizona|Senhwa Biosciences Inc. January 1 2021 Phase 2
NCT04663737 Active not recruiting Drug: Silmitasertib|Drug: SOC Covid19 Chris Recknor MD|Senhwa Biosciences Inc. December 3 2020 Phase 2
NCT03904862 Recruiting Drug: CX 4945 Medulloblastoma Childhood Pediatric Brain Tumor Consortium|St. Jude Children''s Research Hospital|National Cancer Institute (NCI) March 18 2019 Phase 1|Phase 2
NCT02128282 Active not recruiting Drug: CX-4945|Drug: Cisplatin|Drug: Gemcitabine Cholangiocarcinoma Senhwa Biosciences Inc. June 2014 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
Tags: buy Silmitasertib (CX-4945) sodium salt | Silmitasertib (CX-4945) sodium salt supplier | purchase Silmitasertib (CX-4945) sodium salt | Silmitasertib (CX-4945) sodium salt cost | Silmitasertib (CX-4945) sodium salt manufacturer | order Silmitasertib (CX-4945) sodium salt | Silmitasertib (CX-4945) sodium salt distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID