Home PI3K/Akt/mTOR PP2A inhibitor Sodium Demethylcantharidate For research use only.

Sodium Demethylcantharidate

Synonyms: Sodium norcantharidin

Demethylcantharidin (norcantharidin) is a synthetic analogue of cantharidin and has potent antitumor activity.

Sodium Demethylcantharidate Chemical Structure

Sodium Demethylcantharidate Chemical Structure

CAS: 13114-29-9

Purity & Quality Control

Batch: S386101 Water] 41 mg/mL] false] DMSO] Insoluble] false] ] ] false Purity: 98%
98

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Biological Activity

Description Demethylcantharidin (norcantharidin) is a synthetic analogue of cantharidin and has potent antitumor activity.
In vitro
In vitro Demethylcantharidin (DMC) is also found to be highly effective in inhibiting the growth of mouse hepatocytes, with an IC50 of about 10 μM[1].
Cell Research Cell lines SK-Hep1 and HepG2 cells
Concentrations 2-200 μM
Incubation Time 72 h
Method Cells are seeded in 96-well microtiter plates (1×104/well; 100 μl) and allowed to equilibrate in quadruplicate wells and exposed to drugs (cisplatin, 1-5 and DMC: 2-200 μM; carboplatin: 50-3000 μM) for 72 h. After which, MTT (5 mg/ml, 20 ml) in phosphate-buffered saline is added and the cells are incubated for 4 h at 37℃. MTT/medium is then removed and the formazan product is dissolved in DMSO (150 ml) and absorbance is measured at 570 nm using a microtiter plate reader

Chemical Information & Solubility

Molecular Weight 208.14 Formula

C8H9O5.Na
CAS No. 13114-29-9 SDF --
Smiles C1CC2C(C(C1O2)C(=O)[O-])C(=O)[O-].[Na+].[Na+]
Storage (From the date of receipt)

In vitro
Batch:

Water : 41 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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