Home Biosimilar Antibodies Immunology & Inflammation Interleukins inhibitor Secukinumab (anti-IL-17A) For research use only.
Not for use in humans.

Secukinumab (anti-IL-17A)

Synonyms: AIN457

Secukinumab (anti-IL-17A) (AIN457) is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is applied for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. MW=147.9 kDa.

Secukinumab (anti-IL-17A)

Click to purchase the isotype control of Secukinumab (anti-IL-17A)

Selleck's Secukinumab (anti-IL-17A) has been cited by 3 publications

Purity & Quality Control

Batch: A202501 Purity: 99.82% Protein concentration: 5.00mg/ml Endotoxin Level: <1EU/mg
99.82

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description Secukinumab (anti-IL-17A) (AIN457) is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is applied for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. MW=147.9 kDa.
In Vitro
In vitro

Secukinumab can reduce cell growth in the miR130b-knockdown OCI-ly10 co-culture system.[1]
Cell Research:

MTT assay was adopted to measure cell growth in the control inhibitor or miR130b inhibitor transfected OCI-ly10 co-culture system upon treatment with or without IL17 inhibitor.
In Vivo
In vivo

Secukinumab administration significantly attenuates AAV8-IRF8 mediated recruitment of neutrophils, also downregulates the autophagy level and inhibits the release of either autophagy-dependent or independent chemokines in vivo.[2]
Animal Research

Animal Models: C57BL/6 mice, IRF8 FLOX mice (C57BL/6J background)
Dosages: 200 μg
Administration: i.p.
Reference: https://pubmed.ncbi.nlm.nih.gov/34400126/
 
  • https://pubmed.ncbi.nlm.nih.gov/35301282/
  • https://pubmed.ncbi.nlm.nih.gov/34400126/

Product Details

CAS No. 1229022-83-6
Isotype Human IgG1
Source Human
Sterility 0.2 μM filtered
Formulation PBS buffer, pH 7.2
Storage
(From the date of receipt)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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