Secukinumab (anti-IL-17A)

Catalog No.A2025 Synonyms: Cosentyx, AIN457

For research use only.
Not for use in humans.

Secukinumab (anti-IL-17A) (Cosentyx, AIN457) is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is applied for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. MW=147.9 kDa.

Secukinumab (anti-IL-17A)

Selleck's Secukinumab (anti-IL-17A) has been cited by 2 Publications

Purity & Quality Control

Choose Selective Interleukins Inhibitors

Biological Activity

Description Secukinumab (anti-IL-17A) (Cosentyx, AIN457) is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is applied for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. MW=147.9 kDa.
In vitro

Secukinumab can reduce cell growth in the miR130b-knockdown OCI-ly10 co-culture system.[1]

In vivo

Secukinumab administration significantly attenuates AAV8-IRF8 mediated recruitment of neutrophils, also downregulates the autophagy level and inhibits the release of either autophagy-dependent or independent chemokines in vivo.[2]

Protocol (from reference)

Cell Research:
  • MTT assay was adopted to measure cell growth in the control inhibitor or miR130b inhibitor transfected OCI-ly10 co-culture system upon treatment with or without IL17 inhibitor.

Animal Research:
  • Animal Models: C57BL/6 mice, IRF8 FLOX mice (C57BL/6J background)
    Dosages: 200 μg
    Administration: i.p.
    Reference: https://pubmed.ncbi.nlm.nih.gov/34400126/
     

Product Details

CAS No. 1229022-83-6
Formulation PBS buffer, pH 7.2
Isotype Human IgG1
Source Human
Storage Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

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