For research use only.

Catalog No.S4082 Synonyms: Formacidine

1 publication

Spiramycin Chemical Structure

CAS No. 8025-81-8

Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic).

Selleck's Spiramycin has been cited by 1 publication

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Biological Activity

Description Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic).
In vitro

Spiramycin reduces the hygromycin A protections of nucleotides in 23 S rRNA. [1] Spiramycin, a 16-membered macrolide, inhibits translocation by binding to bacterial 50S ribosomal subunits with an apparent 1:1 stoichiometry. Spiramycin acts primarily by stimulating the dissociation of peptidyl-tRNA from ribosomes during translocation. [2] Spiramycin at doses sufficient to inhibit protein synthesis in wild-type cells but not sufficient to kill either mutant or wild-type cells at the permissive temperature (30 degrees C). Spiramycin inhibits protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. [3] Spiramycin shows dose-related inhibition of the proliferative response of PHA and PWM stimulated human mononuclear leucocytes (MNL). Spiramycin also induces a decrease in tritiated uridine (3H-UdR) uptake, which suggests that Spiramycin interferes with an early event in the cell cycle. [4] Spiramycin and, to a lesser extent, erythromycin increases total IL-6 production without affecting IL-1 alpha, IL-1 beta, or tumor necrosis factor alpha production in human monocytes stimulated with lipopolysaccharide. [5] Spiramycin shows good antimicrobial activity against species of Prevotella, Eubacterium, Peptostreptococcus, Bacteroides and Porphyromonas, and the effect is enhanced by the addition of Metronidazole. [6]


Solubility (25°C)

In vitro DMSO 100 mg/mL (118.61 mM)
Water Insoluble
Ethanol '100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 843.05


CAS No. 8025-81-8
Storage powder
in solvent
Synonyms Formacidine

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID