Catalog No.S1398 Synonyms: BMY-27857, Sanilvudine, NSC 163661
Molecular Weight(MW): 224.21
Stavudine (d4T) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.
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|Description||Stavudine (d4T) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.|
Stavudine alteres the lipid phenotype, decreasing the lipid content and expression of markers involved in lipid metabolism, namely C/EBPalpha, peroxisome proliferator-activated receptor gamma, adipocyte lipid binding protein 2, fatty acid synthase and acetyl-coenzyme A carboxylase. Stavudine drives 5-10% of 3T3-F442A cells towards apoptosis, and reduces the lipid content and survival of differentiated 3T3-L1 adipocytes. Stavudine increases mitochondrial mass by two to fourfold, and loweres the mitochondrial membrane potential (JC-1 stain).  stavudine inhibits p24 antigen production by HIV-I in PBMC with EDsos ranging from 0.04 μM to 0.2 μM.  Stavudine produces significant mitochondrial dysfunction with a 1.5-fold increase in cellular lactate to pyruvate ratios. Stavudine causes a dose-dependent decrease in mtDNA amplification and a correlative increase in abundance of markers of mitochondrial oxidative stress. Stavudine treatment elevates mitochondrial reactive oxygen species (ROS), enhances mitochondrial oxidative stress, and contributes mechanistically to NRTI-induced toxicity. 
|In vivo||Stavudine (500 mg/kg/day) results in lack of significant oxidative mtDNA lesions (as assessed by long polymerase chain reaction experiments), and normal blood lactate/pyruvate ratios in lean mice. Stavudine (500 mg/kg/day) can decrease hepatic and muscle mtDNA in lean mice and can also cause ketoacidosis during fasting without altering mtDNA. Stavudine (500 mg/kg/day) depletes WAT mtDNA only in obese mice. |
|In vitro||DMSO||45 mg/mL (200.7 mM)|
|Ethanol||15 mg/mL (66.9 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
0.5% CMC Na
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||BMY-27857, Sanilvudine, NSC 163661|
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01178684||Completed||--||HIV||South East Asia Research Collaboration with Hawaii|University of Hawaii||May 2010||--|
|NCT00455585||Completed||Drug: nevirapine stavudine lamivudine||HIV Infections||Makerere University|Department of Foreign Affairs Ireland||January 2007||Phase 4|
|NCT00235222||Unknown status||Drug: stavudine||HIV||Groupe Hospitalier Pitie-Salpetriere|Bristol-Myers Squibb||June 2004||Phase 4|
|NCT00116116||Completed||Drug: efavirenz stavudine extended release lamivudine||HIV Infections|AIDS||Bristol-Myers Squibb||March 2002||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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