Home Microbiology HIV Protease inhibitor Saquinavir (Ro 31-8959)

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Saquinavir (Ro 31-8959) HIV Protease inhibitor

Cat.No.S9625

Saquinavir (Ro 31-8959,SAQ) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.
Saquinavir (Ro 31-8959) HIV Protease inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 670.84

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Quality Control

Batch: S962501 DMSO]100 mg/mL]false]Ethanol]25 mg/mL]false]Water]Insoluble]false Purity: 99.57%
99.57

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (149.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 25 mg/mL

Water : Insoluble

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%
% Tween 80
% ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 670.84 Formula

C38H50N6O5

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 127779-20-8 -- Storage of Stock Solutions

Synonyms Ro 31-8959,SAQ Smiles CC(C)(C)NC(=O)C1CC2CCCCC2CN1CC(O)C(CC3=CC=CC=C3)NC(=O)C(CC(N)=O)NC(=O)C4=NC5=CC=CC=C5C=C4

Mechanism of Action

Targets/IC50/Ki
HIV proteinase
(in JM cells)
2.7 nM
In vitro

Saquinavir (Ro 31-8959) is an effective selective HIV protease inhibitor with an average IC50 of 2.7 nM in JM cells, which inhibits the spread of HIV infection and the production of cytopathic effects.<sup><a class="sref" href="#s_ref">[1]</a></sup>
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05997693 Not yet recruiting
Chronic Coronary Disease
Weill Medical College of Cornell University|Canadian Institutes of Health Research (CIHR)
 October 2024 Phase 3
NCT06406218 Recruiting
Acute Myocardial Infarction|Phase I Cardiac Rehabilitation
Han Yaling MD|Shenyang Northern Hospital
 April 24 2024 Not Applicable
NCT06340009 Recruiting
Bell Palsy
Riphah International University
 March 22 2024 Not Applicable

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