Solithromycin

Catalog No.S5268 Synonyms: CEM-101, OP-1068

For research use only.

Solithromycin (CEM-101, OP-1068), belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor.

Solithromycin Chemical Structure

CAS No. 760981-83-7

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Solithromycin (CEM-101, OP-1068), belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 845.01
Formula

C43H65FN6O10

CAS No. 760981-83-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)(C)F)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=N4)C5=CC(=CC=C5)N)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02628769 Terminated Drug: Solithromycin|Drug: Placebo Pulmonary Disease Chronic Obstructive Imperial College London|Melinta Therapeutics Inc. July 2015 Phase 2
NCT02348424 Completed Drug: Solithromycin Gonorrhoea National Institute of Allergy and Infectious Diseases (NIAID) May 5 2015 Phase 1
NCT02268279 Completed Drug: solithromycin Bacterial Infection Melinta Therapeutics Inc.|Department of Health and Human Services January 2015 Phase 1
NCT02210325 Completed Drug: solithromycin|Drug: ceftriaxone|Drug: azithromycin Uncomplicated Urogenital Gonorrhea Melinta Therapeutics Inc.|National Institute of Allergy and Infectious Diseases (NIAID) August 2014 Phase 3
NCT01966055 Completed Drug: Solithromycin Bacterial Infections Melinta Therapeutics Inc.|Department of Health and Human Services December 2013 Phase 1
NCT01591447 Completed Drug: solithromycin|Drug: Solithromycin (CEM-101) Uncomplicated Urogenital Gonorrhea Melinta Therapeutics Inc. May 2012 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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