Solithromycin

For research use only.

Catalog No.S5268 Synonyms: CEM-101, OP-1068

Solithromycin Chemical Structure

CAS No. 760981-83-7

Solithromycin (CEM-101, OP-1068), belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor.

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Solithromycin (CEM-101, OP-1068), belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor.

Protocol

References

Solubility (25°C)

In vitro DMSO 100 mg/mL (118.34 mM)
Water Insoluble
Ethanol ''25 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 845.01
Formula

C43H65FN6O10

CAS No. 760981-83-7
Storage powder
in solvent
Synonyms CEM-101, OP-1068
Smiles CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)(C)F)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=N4)C5=CC(=CC=C5)N)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation ()
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02628769 Terminated Drug: Solithromycin|Drug: Placebo Pulmonary Disease Chronic Obstructive Imperial College London|Melinta Therapeutics Inc. July 2015 Phase 2
NCT02348424 Completed Drug: Solithromycin Gonorrhoea National Institute of Allergy and Infectious Diseases (NIAID) May 5 2015 Phase 1
NCT02268279 Completed Drug: solithromycin Bacterial Infection Melinta Therapeutics Inc.|Department of Health and Human Services January 2015 Phase 1
NCT02210325 Completed Drug: solithromycin|Drug: ceftriaxone|Drug: azithromycin Uncomplicated Urogenital Gonorrhea Melinta Therapeutics Inc.|National Institute of Allergy and Infectious Diseases (NIAID) August 2014 Phase 3
NCT01966055 Completed Drug: Solithromycin Bacterial Infections Melinta Therapeutics Inc.|Department of Health and Human Services December 2013 Phase 1
NCT01591447 Completed Drug: solithromycin|Drug: Solithromycin (CEM-101) Uncomplicated Urogenital Gonorrhea Melinta Therapeutics Inc. May 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID