Home JAK/STAT JAK inhibitor - Interleukins inhibitor - IFN inhibitor SAR-20347 For research use only.

SAR-20347

SAR-20347 is a potent inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50 of 0.6 nM, 23 nM, 26 nM and 41 nM, respectively. SAR-20347 inhibits TYK2- and JAK1-mediated IL-12 and IFN-α signaling.

SAR-20347 Chemical Structure

SAR-20347 Chemical Structure

CAS: 1450881-55-6

Selleck's SAR-20347 has been cited by 1 publication

Purity & Quality Control

Batch: S043701 DMSO] 89 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 97.24%
97.24

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Signaling Pathway

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Biological Activity

Description SAR-20347 is a potent inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50 of 0.6 nM, 23 nM, 26 nM and 41 nM, respectively. SAR-20347 inhibits TYK2- and JAK1-mediated IL-12 and IFN-α signaling.
Targets
IL-12 [1] IFN-α [1] TYK2 [1]
(Cell-free assay)		 JAK1 [1]
(Cell-free assay)		 JAK2 [1]
(Cell-free assay)		 Click to View More Targets
0.6 nM 23 nM 26 nM

Chemical Information & Solubility

Molecular Weight 444.84 Formula

C21H18ClFN4O4
CAS No. 1450881-55-6 SDF --
Smiles C1COCCN1C(=O)C2=CC=C(C=C2)NC3=C(N=C(O3)C4=C(C=CC=C4Cl)F)C(=O)N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 89 mg/mL ( (200.07 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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