Home Apoptosis FKBP modulator - Calcium Channel modulator S107 hydrochloride For research use only.

S107 hydrochloride

S107 hydrochloride is a specific stabilizer of RyR2 (type 2 ryanodine receptor)/FKBP12.6 (FK506 binding protein 12.6) complex that affects Ca2+ signaling.

S107 hydrochloride Chemical Structure

S107 hydrochloride Chemical Structure

CAS: 1357476-46-0

Purity & Quality Control

Batch: S071301 Water] 49 mg/mL] false] DMSO] 24 mg/mL] false] Ethanol] 10 mg/mL] false Purity: 99.25%
99.25

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Biological Activity

Description S107 hydrochloride is a specific stabilizer of RyR2 (type 2 ryanodine receptor)/FKBP12.6 (FK506 binding protein 12.6) complex that affects Ca2+ signaling.
Targets
RyR2/FKBP12.6 complex [1]
In Vivo
In vivo

S107, a novel RyR2-specific compound that enhances the binding of calstabin2 to the mutant Ryr2-R2474S channel, inhibits the channel leak and prevents cardiac arrhythmias and raises the seizure threshold.[1]
Animal Research Animal Models Ryr2RS/WT and WT mice
Dosages 5 mg/kg/h
Administration s.c. osmotic pump

Chemical Information & Solubility

Molecular Weight 245.77 Formula

C11H16ClNOS
CAS No. 1357476-46-0 SDF --
Smiles CN1CCSC2=C(C1)C=C(C=C2)OC.Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 49 mg/mL

DMSO : 24 mg/mL ( (97.65 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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