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Substance P Neurokinin Receptor agonist

Name: Substance P
Brand: Selleck Chemicals
SKU: E8168
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E8168

Substance P (Neurokinin P) is an 11-amino-acid neuropeptide and an agonist for the neurokinin-1 receptor (NK1R), binding with high affinity to regulate pain, anxiety, and stress responses. It is present in the CNS and PNS, playing a key role in neurotransmission, neuromodulation, and wound healing research.

Chemical Structure

Molecular Weight: 1347.63

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Quality Control

Batch: E816801 DMSO]100 mg/mL]false]Water]50 mg/mL]false]Ethanol]Insoluble]false Purity: 98.91%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS/MSDS
Datasheet

98.91

Related Targets	CXCR Hedgehog/Smoothened PKA Adrenergic Receptor AChR 5-HT Receptor Histamine Receptor Dopamine Receptor Ras KRas
Other Neurokinin Receptor Inhibitors	Tradipitant L-732138 Fezolinetant Asparagus Extract Elinzanetant Maropitant citrate

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (74.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 50 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	1347.63	Formula	C₆₃H₉₈N₁₈O₁₃S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	33507-63-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/35054936/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-05-11)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06462287	RECRUITING	Apnea, Obstructive	University Hospital, Rouen	2024-03-05	PHASE2
NCT07585721	NOT_YET_RECRUITING	Symptomatic Apical Periodontitis	Future University in Egypt	2026-06-01
NCT07701551	NOT_YET_RECRUITING	Symptomatic Irreversible Pulpitis (SIP)	Cairo University	2026-08-01	PHASE4
NCT07453576	RECRUITING	Persistent Apical Periodontitis	KEZBAN MELTEM ÇOLAK	2025-10-01
NCT06959004	RECRUITING	Migraine	Danish Headache Center	2025-05-13
NCT06632080	NOT_YET_RECRUITING	Healthy Volunteers Only	Danish Headache Center	2024-10-14

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