SIB 1757

Catalog No.S2645

For research use only.

SIB 1757 is a highly selective, noncompetitive antagonist of metabotropic glutamate receptor type 5 (mGluR5) with IC50 of 0.4 μM at hmGluR5 compared with >30 µM at hmGluR1b, hmGluR2, hmGluR4, hmGluR6, hmGluR7 and hmGluR8.

SIB 1757 Chemical Structure

CAS No. 31993-01-8

Purity & Quality Control

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Biological Activity

Description SIB 1757 is a highly selective, noncompetitive antagonist of metabotropic glutamate receptor type 5 (mGluR5) with IC50 of 0.4 μM at hmGluR5 compared with >30 µM at hmGluR1b, hmGluR2, hmGluR4, hmGluR6, hmGluR7 and hmGluR8.
Targets
mGluR5 [1]
(Cell-free assay)
0.4 μM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 22 mg/mL
(103.17 mM)
Ethanol 9 mg/mL
(42.2 mM)
Water Insoluble

Chemical Information

Molecular Weight 213.24
Formula

C12H11N3O

CAS No. 31993-01-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=NC(=C(C=C1)O)N=NC2=CC=CC=C2

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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